drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00877 | DB10795 | 629 | 221 | [
"DDInter1678",
"DDInter1486"
] | Sirolimus | Poliovirus type 1 antigen (formaldehyde inactivated) | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
629,
24,
221
]
],
[
[
629,
64,
581
],
[
581,
24,
221
]
],
[
[
629,
63,
599
],
[
599,
24,
221
]
],
[
[
629,
24,
1486
],
[
1486,
2... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"In... | Sirolimus may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00674 | DB00747 | 1,516 | 1,442 | [
"DDInter802",
"DDInter1647"
] | Galantamine | Scopolamine | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
1516,
24,
1442
]
],
[
[
1516,
63,
19
],
[
19,
24,
1442
]
],
[
[
1516,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
1516,
24,
543
],
[
543,
... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Galantamine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Scopolami... |
DB00358 | DB00776 | 1,010 | 1,335 | [
"DDInter1140",
"DDInter1360"
] | Mefloquine | Oxcarbazepine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
1010,
24,
1335
]
],
[
[
1010,
24,
1264
],
[
1264,
63,
1335
]
],
[
[
1010,
24,
1236
],
[
1236,
1,
1335
]
],
[
[
1010,
63,
902
],
[
902,... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbam... |
DB00860 | DB01197 | 891 | 1,603 | [
"DDInter1513",
"DDInter292"
] | Prednisolone | Captopril | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
891,
24,
1603
]
],
[
[
891,
63,
610
],
[
610,
1,
1603
]
],
[
[
891,
6,
4973
],
[
4973,
45,
1603
]
],
[
[
891,
21,
29081
],
[
29081,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
[
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Prednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Captopril (Compound)
Prednisolone (Compound) causes Angioedema (Side Effect) and Angioede... |
DB00731 | DB01067 | 1,144 | 959 | [
"DDInter1269",
"DDInter826"
] | Nateglinide | Glipizide | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1144,
24,
959
]
],
[
[
1144,
63,
245
],
[
245,
40,
959
]
],
[
[
1144,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1144,
5,
11640
],
[
11640,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compou... |
DB01218 | DB01611 | 1,493 | 1,487 | [
"DDInter852",
"DDInter893"
] | Halofantrine | Hydroxychloroquine | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1493,
25,
1487
]
],
[
[
1493,
64,
1520
],
[
1520,
25,
1487
]
],
[
[
1493,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
1493,
21,
28658
],
[
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Halofantrine may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Halofantrine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Halofantrine (Compound) caus... |
DB00099 | DB01041 | 440 | 770 | [
"DDInter735",
"DDInter1789"
] | Filgrastim | Thalidomide | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
440,
24,
770
]
],
[
[
440,
24,
1668
],
[
1668,
1,
770
]
],
[
[
440,
24,
4
],
[
4,
63,
770
]
],
[
[
440,
24,
168
],
[
168,
24,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
],
[... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may caus... |
DB00188 | DB12267 | 168 | 1,476 | [
"DDInter222",
"DDInter233"
] | Bortezomib | Brigatinib | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Minor | 0 | [
[
[
168,
23,
1476
]
],
[
[
168,
63,
1184
],
[
1184,
24,
1476
]
],
[
[
168,
24,
800
],
[
800,
24,
1476
]
],
[
[
168,
23,
968
],
[
968,
... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Brigatinib"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib and Duvelisib m... |
DB00262 | DB01610 | 552 | 248 | [
"DDInter302",
"DDInter1912"
] | Carmustine | Valganciclovir | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
552,
24,
248
]
],
[
[
552,
24,
563
],
[
563,
1,
248
]
],
[
[
552,
21,
29209
],
[
29209,
60,
248
]
],
[
[
552,
24,
372
],
[
372,
... | [
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Carmustine (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Valganciclovir (Compound)
Carmustine may cause a moderate inte... |
DB00277 | DB00683 | 1,031 | 1,382 | [
"DDInter1791",
"DDInter1212"
] | Theophylline | Midazolam | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Minor | 0 | [
[
[
1031,
23,
1382
]
],
[
[
1031,
23,
1216
],
[
1216,
40,
1382
]
],
[
[
1031,
62,
905
],
[
905,
40,
1382
]
],
[
[
1031,
6,
8374
],
[
8374,... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Midazolam"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Flurazepam"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Flurazepam and Flurazepam (Compound) resembles Midazolam (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Lorazepam and Lorazepam (Compound) resembles Midazolam (Compound)
Theo... |
DB00910 | DB09293 | 1,041 | 116 | [
"DDInter1394",
"DDInter954"
] | Paricalcitol | Iodide I-131 | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1041,
24,
116
]
],
[
[
1041,
6,
8374
],
[
8374,
45,
1486
],
[
1486,
24,
116
]
],
[
[
1041,
21,
28997
],
[
28997,
60,
1486
],
[
1486,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Paricalcitol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Paricalcitol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Paricalcitol (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Eff... |
DB01182 | DB04868 | 371 | 478 | [
"DDInter1534",
"DDInter1293"
] | Propafenone | Nilotinib | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
371,
25,
478
]
],
[
[
371,
6,
6017
],
[
6017,
45,
478
]
],
[
[
371,
18,
4884
],
[
4884,
57,
478
]
],
[
[
371,
21,
31778
],
[
31778,
... | [
[
[
"Propafenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Propafenone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Niloti... | Propafenone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Propafenone (Compound) downregulates POLR2I (Gene) and POLR2I (Gene) is downregulated by Nilotinib (Compound)
Propafenone (Compound) causes Bundle branch block left (Side Effect) and Bundle branch block left (Side Effect) is c... |
DB01098 | DB09389 | 14 | 517 | [
"DDInter1622",
"DDInter1315"
] | Rosuvastatin | Norgestrel | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Minor | 0 | [
[
[
14,
23,
517
]
],
[
[
14,
63,
581
],
[
581,
24,
517
]
],
[
[
14,
24,
908
],
[
908,
24,
517
]
],
[
[
14,
62,
600
],
[
600,
24,
... | [
[
[
"Rosuvastatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Norgestrel"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Infliximab"
],
[
... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Golimumab and Gol... |
DB00026 | DB08868 | 1,184 | 1,011 | [
"DDInter94",
"DDInter737"
] | Anakinra | Fingolimod | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1184,
25,
1011
]
],
[
[
1184,
24,
748
],
[
748,
63,
1011
]
],
[
[
1184,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
1184,
25,
976
],
[
976,
... | [
[
[
"Anakinra",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Anthrax v... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Denosumab and D... |
DB00358 | DB00539 | 1,010 | 11 | [
"DDInter1140",
"DDInter1837"
] | Mefloquine | Toremifene | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
1010,
25,
11
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
11
]
],
[
[
1010,
7,
9650
],
[
9650,
46,
11
]
],
[
[
1010,
18,
2183
],
[
2183,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Toremifen... | Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Toremifene (Compound)
Mefloquine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Toremifene (Compound)
Mefloquine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Toremifene (Compound)
Mefloquine (Co... |
DB00261 | DB00712 | 702 | 1,274 | [
"DDInter93",
"DDInter763"
] | Anagrelide | Flurbiprofen | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
702,
24,
1274
]
],
[
[
702,
24,
1119
],
[
1119,
1,
1274
]
],
[
[
702,
24,
935
],
[
935,
63,
1274
]
],
[
[
702,
7,
3218
],
[
3218,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlordiazepoxide"
],
... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Chlordiazepoxide and Chlordiazepoxide (Compound) resembles Flurbiprofen (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interact... |
DB01234 | DB06016 | 1,220 | 1,508 | [
"DDInter513",
"DDInter300"
] | Dexamethasone | Cariprazine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1220,
24,
1508
]
],
[
[
1220,
24,
1593
],
[
1593,
63,
1508
]
],
[
[
1220,
63,
600
],
[
600,
24,
1508
]
],
[
[
1220,
25,
1213
],
[
1213... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB00063 | DB11095 | 366 | 235 | [
"DDInter659",
"DDInter505"
] | Eptifibatide | Desirudin | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
366,
25,
235
]
],
[
[
366,
23,
297
],
[
297,
23,
235
]
],
[
[
366,
24,
1100
],
[
1100,
24,
235
]
],
[
[
366,
63,
1595
],
[
1595,
... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
... | Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may ... |
DB00775 | DB08816 | 1,226 | 578 | [
"DDInter1818",
"DDInter1802"
] | Tirofiban | Ticagrelor | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1226,
24,
578
]
],
[
[
1226,
5,
11576
],
[
11576,
44,
578
]
],
[
[
1226,
54,
19166
],
[
19166,
15,
578
]
],
[
[
1226,
21,
28762
],
[
2... | [
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Tirofiban",
"{u} (Compound) treats {v} (Disease)",
"coronary artery disease"
],
[
"coronary artery disease",
"{u}... | Tirofiban (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Ticagrelor (Compound)
Tirofiban (Compound) is included by Decreased Platelet Aggregation (Pharmacologic Class) and Decreased Platelet Aggregation (Pharmacologic Class) includes Ticagrelor (Compound)
Tirofib... |
DB00405 | DB09118 | 128 | 1,580 | [
"DDInter517",
"DDInter1711"
] | Dexbrompheniramine | Stiripentol | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
128,
24,
1580
]
],
[
[
128,
24,
1532
],
[
1532,
24,
1580
]
],
[
[
128,
24,
1609
],
[
1609,
63,
1580
]
],
[
[
128,
74,
1594
],
[
1594,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Pent... |
DB00570 | DB11989 | 147 | 1,434 | [
"DDInter1936",
"DDInter183"
] | Vinblastine | Benznidazole | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
147,
24,
1434
]
],
[
[
147,
24,
788
],
[
788,
24,
1434
]
],
[
[
147,
25,
375
],
[
375,
24,
1434
]
],
[
[
147,
24,
148
],
[
148,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Vinblastine may lead to a major life threatening interaction when taken with Certolizumab pegol and Certo... |
DB00059 | DB00532 | 1,560 | 208 | [
"DDInter1404",
"DDInter1152"
] | Pegaspargase | Mephenytoin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
1560,
24,
208
]
],
[
[
1560,
24,
168
],
[
168,
23,
208
]
],
[
[
1560,
24,
1613
],
[
1613,
63,
208
]
],
[
[
1560,
25,
908
],
[
908,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Mephenytoin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta... |
DB01142 | DB13913 | 1,264 | 1,536 | [
"DDInter593",
"DDInter175"
] | Doxepin | Belladonna | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
1264,
24,
1536
]
],
[
[
1264,
24,
849
],
[
849,
24,
1536
]
],
[
[
1264,
63,
128
],
[
128,
24,
1536
]
],
[
[
1264,
74,
1376
],
[
1376,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
"M... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexb... |
DB00278 | DB14357 | 291 | 944 | [
"DDInter117",
"DDInter347"
] | Argatroban | Chamomile | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
291,
23,
944
]
],
[
[
291,
25,
256
],
[
256,
23,
944
]
],
[
[
291,
64,
582
],
[
582,
23,
944
]
],
[
[
291,
24,
1061
],
[
1061,
2... | [
[
[
"Argatroban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Argatroban may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Argatroban may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a minor interaction th... |
DB06700 | DB09268 | 643 | 1,662 | [
"DDInter511",
"DDInter1464"
] | Desvenlafaxine | Picosulfuric acid | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
643,
24,
1662
]
],
[
[
643,
24,
1618
],
[
1618,
24,
1662
]
],
[
[
643,
64,
73
],
[
73,
24,
1662
]
],
[
[
643,
63,
820
],
[
820,
... | [
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Desvenlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib... | Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Desvenlafaxine may lead to a major life threatening interaction when taken with Phentermine and P... |
DB01285 | DB10795 | 708 | 221 | [
"DDInter445",
"DDInter1486"
] | Corticotropin | Poliovirus type 1 antigen (formaldehyde inactivated) | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
708,
24,
221
]
],
[
[
708,
64,
581
],
[
581,
24,
221
]
],
[
[
708,
63,
599
],
[
599,
24,
221
]
],
[
[
708,
24,
1531
],
[
1531,
2... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Corticotropin",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Corticotropin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Corticotropin may cause a moderate interaction that could exacerbate diseases when... |
DB01238 | DB12500 | 673 | 283 | [
"DDInter118",
"DDInter714"
] | Aripiprazole | Fedratinib | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
673,
24,
283
]
],
[
[
673,
24,
351
],
[
351,
23,
283
]
],
[
[
673,
63,
1419
],
[
1419,
24,
283
]
],
[
[
673,
24,
761
],
[
761,
2... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatin... |
DB01222 | DB04865 | 617 | 4 | [
"DDInter246",
"DDInter1335"
] | Budesonide | Omacetaxine mepesuccinate | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
617,
24,
4
]
],
[
[
617,
7,
10351
],
[
10351,
46,
4
]
],
[
[
617,
18,
3169
],
[
3169,
46,
4
]
],
[
[
617,
6,
1899
],
[
1899,
46,... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Budesonide",
"{u} (Compound) upregulates {v} (Gene)",
"ATF6"
],
[
"ATF6",
"{u} (Gene) is upregula... | Budesonide (Compound) upregulates ATF6 (Gene) and ATF6 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Budesonide (Compound) downregulates SQSTM1 (Gene) and SQSTM1 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Budesonide (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulated by Omac... |
DB00927 | DB06723 | 1,559 | 115 | [
"DDInter712",
"DDInter58"
] | Famotidine | Aluminum hydroxide | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Minor | 0 | [
[
[
1559,
23,
115
]
],
[
[
1559,
21,
28872
],
[
28872,
60,
115
]
],
[
[
1559,
63,
1630
],
[
1630,
23,
115
]
],
[
[
1559,
24,
401
],
[
401,... | [
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Famotidine",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{u} (Side E... | Famotidine (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Aluminum hydroxide (Compound)
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine may cause a minor interaction that can limit clinical effects when ... |
DB01168 | DB01242 | 1,053 | 1,237 | [
"DDInter1526",
"DDInter410"
] | Procarbazine | Clomipramine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Major | 2 | [
[
[
1053,
25,
1237
]
],
[
[
1053,
63,
684
],
[
684,
1,
1237
]
],
[
[
1053,
64,
1164
],
[
1164,
1,
1237
]
],
[
[
1053,
63,
272
],
[
272,
... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
[
"Th... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Procarbazine may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)... |
DB00001 | DB00063 | 1,578 | 366 | [
"DDInter1037",
"DDInter659"
] | Lepirudin | Eptifibatide | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Major | 2 | [
[
[
1578,
25,
366
]
],
[
[
1578,
23,
944
],
[
944,
62,
366
]
],
[
[
1578,
24,
311
],
[
311,
63,
366
]
],
[
[
1578,
25,
477
],
[
477,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
]
],
[
[
"Lepirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Lepirudin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Eptifibatide
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib and Valdecoxib m... |
DB01181 | DB15091 | 1,532 | 676 | [
"DDInter906",
"DDInter1901"
] | Ifosfamide | Upadacitinib | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1532,
25,
676
]
],
[
[
1532,
63,
1461
],
[
1461,
23,
676
]
],
[
[
1532,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1532,
24,
1654
],
[
1654,... | [
[
[
"Ifosfamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipule... |
DB00434 | DB00601 | 13 | 453 | [
"DDInter459",
"DDInter1073"
] | Cyproheptadine | Linezolid | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
13,
24,
453
]
],
[
[
13,
18,
7669
],
[
7669,
46,
453
]
],
[
[
13,
7,
2900
],
[
2900,
46,
453
]
],
[
[
13,
7,
7095
],
[
7095,
57,... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) downregulates {v} (Gene)",
"DDIT4"
],
[
"DDIT4",
"{u} (Gene) is upregulated ... | Cyproheptadine (Compound) downregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Linezolid (Compound)
Cyproheptadine (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Linezolid (Compound)
Cyproheptadine (Compound) upregulates CCL2 (Gene) and CCL2 (Gene) is downregulated by Linezolid (Compo... |
DB00544 | DB11943 | 970 | 255 | [
"DDInter757",
"DDInter495"
] | Fluorouracil | Delafloxacin | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
970,
23,
255
]
],
[
[
970,
24,
1001
],
[
1001,
23,
255
]
],
[
[
970,
64,
377
],
[
377,
23,
255
]
],
[
[
970,
63,
134
],
[
134,
2... | [
[
[
"Fluorouracil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
],... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Fluorouracil may lead to a major life threatening interaction when taken with Mitomycin and Mitomyci... |
DB00524 | DB06203 | 811 | 1,002 | [
"DDInter1199",
"DDInter51"
] | Metolazone | Alogliptin | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
811,
24,
1002
]
],
[
[
811,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
811,
21,
28873
],
[
28873,
60,
1002
]
],
[
[
811,
24,
401
],
[
401,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Metolazone (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Alogliptin (Compound)
Metolazone may cause a moderate inte... |
DB01068 | DB01156 | 1,565 | 593 | [
"DDInter411",
"DDInter252"
] | Clonazepam | Bupropion | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
1565,
24,
593
]
],
[
[
1565,
6,
8374
],
[
8374,
45,
593
]
],
[
[
1565,
10,
11621
],
[
11621,
49,
593
]
],
[
[
1565,
21,
28757
],
[
287... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Clonazepam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Clonazepam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Clonazepam (Compound) palliates panic disorder (Disease) and panic disorder (Disease) is palliated by Bupropion (Compound)
Clonazepam (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bupropion ... |
DB06754 | DB12500 | 707 | 283 | [
"DDInter471",
"DDInter714"
] | Danaparoid | Fedratinib | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity tha... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
707,
25,
283
]
],
[
[
707,
64,
885
],
[
885,
24,
283
]
],
[
[
707,
63,
529
],
[
529,
24,
283
]
],
[
[
707,
25,
1618
],
[
1618,
2... | [
[
[
"Danaparoid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Danaparoid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
],
[
"Epoprostenol",
"{... | Danaparoid may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Danaparoid may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine and Fluvoxamine may ... |
DB00333 | DB09082 | 576 | 659 | [
"DDInter1166",
"DDInter1934"
] | Methadone | Vilanterol | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
576,
24,
659
]
],
[
[
576,
25,
1220
],
[
1220,
23,
659
]
],
[
[
576,
25,
927
],
[
927,
63,
659
]
],
[
[
576,
25,
1069
],
[
1069,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexametha... | Methadone may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Methadone may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate ... |
DB00494 | DB00668 | 1,533 | 874 | [
"DDInter646",
"DDInter652"
] | Entacapone | Epinephrine | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
1533,
24,
874
]
],
[
[
1533,
24,
1148
],
[
1148,
63,
874
]
],
[
[
1533,
21,
28956
],
[
28956,
60,
874
]
],
[
[
1533,
63,
999
],
[
999,... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Entacapone (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Epineph... |
DB01050 | DB04896 | 848 | 901 | [
"DDInter900",
"DDInter1220"
] | Ibuprofen | Milnacipran | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
848,
24,
901
]
],
[
[
848,
24,
41
],
[
41,
1,
901
]
],
[
[
848,
21,
28723
],
[
28723,
60,
901
]
],
[
[
848,
25,
405
],
[
405,
63... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Ibuprofen (Compound) causes Malnutrition (Side Effect) and Malnutrition (Side Effect) is caused by Milnacipran (Compound)
Ibuprofen may lead to a majo... |
DB00063 | DB00758 | 366 | 1,347 | [
"DDInter659",
"DDInter413"
] | Eptifibatide | Clopidogrel | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Major | 2 | [
[
[
366,
25,
1347
]
],
[
[
366,
25,
1018
],
[
1018,
25,
1347
]
],
[
[
366,
23,
539
],
[
539,
62,
1347
]
],
[
[
366,
24,
266
],
[
266,
... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
]
],
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticlopidine"
],
[
"Ticlopidine",
... | Eptifibatide may lead to a major life threatening interaction when taken with Ticlopidine and Ticlopidine may lead to a major life threatening interaction when taken with Clopidogrel
Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor intera... |
DB00208 | DB09481 | 1,018 | 460 | [
"DDInter1804",
"DDInter1113"
] | Ticlopidine | Magnesium carbonate | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1018,
23,
460
]
],
[
[
1018,
23,
1252
],
[
1252,
23,
460
]
],
[
[
1018,
24,
109
],
[
109,
23,
460
]
],
[
[
1018,
25,
684
],
[
684,
... | [
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Digoxin"
],
... | Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Dulox... |
DB04865 | DB15719 | 4 | 487 | [
"DDInter1335",
"DDInter171"
] | Omacetaxine mepesuccinate | Belantamab mafodotin | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Moderate | 1 | [
[
[
4,
24,
487
]
],
[
[
4,
63,
440
],
[
440,
24,
487
]
],
[
[
4,
24,
810
],
[
810,
24,
487
]
],
[
[
4,
25,
976
],
[
976,
25,
4... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim and Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseas... |
DB00852 | DB00867 | 1,445 | 1,052 | [
"DDInter1545",
"DDInter1606"
] | Pseudoephedrine | Ritodrine | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Adrenergic beta-agonist used to control premature labor. | Moderate | 1 | [
[
[
1445,
24,
1052
]
],
[
[
1445,
63,
1523
],
[
1523,
40,
1052
]
],
[
[
1445,
1,
838
],
[
838,
40,
1052
]
],
[
[
1445,
6,
3576
],
[
3576,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
]
],
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
... | Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ritodrine (Compound)
Pseudoephedrine (Compound) resembles Isoxsuprine (Compound) and Isoxsuprine (Compound) resembles Ritodrine (Compound)
Pseudoephedrine (Compound) binds ADRB2 (... |
DB06688 | DB13915 | 1,430 | 689 | [
"DDInter1677",
"DDInter146"
] | Sipuleucel-T | Axicabtagene ciloleucel | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. The drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. Once T-cells are collected from the patient, they are genetically engineered to express ant... | Moderate | 1 | [
[
[
1430,
24,
689
]
],
[
[
1430,
63,
599
],
[
599,
24,
689
]
],
[
[
1430,
24,
270
],
[
270,
24,
689
]
],
[
[
1430,
24,
976
],
[
976,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axicabtagene ciloleucel"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzuma... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Axicabtagene ciloleucel
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Oc... |
DB00099 | DB11730 | 440 | 351 | [
"DDInter735",
"DDInter1588"
] | Filgrastim | Ribociclib | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
440,
24,
351
]
],
[
[
440,
24,
310
],
[
310,
24,
351
]
],
[
[
440,
24,
738
],
[
738,
63,
351
]
],
[
[
440,
63,
599
],
[
599,
24,... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nirap... |
DB00286 | DB14740 | 380 | 771 | [
"DDInter439",
"DDInter881"
] | Conjugated estrogens | Hyaluronidase | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
380,
23,
771
]
],
[
[
380,
40,
1438
],
[
1438,
23,
771
]
],
[
[
380,
24,
167
],
[
167,
23,
771
]
],
[
[
380,
1,
35
],
[
35,
23,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) resembles {v} (Compound)",
"Estradiol"
],
[
"Estradiol",
"{u} ... | Conjugated estrogens (Compound) resembles Estradiol (Compound) and Estradiol may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a mino... |
DB00480 | DB11866 | 1,668 | 1,068 | [
"DDInter1035",
"DDInter1618"
] | Lenalidomide | Romosozumab | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant to other osteoperosis therapies. Romosozumab prevents bone resorption and induces the formation of bone though it... | Moderate | 1 | [
[
[
1668,
24,
1068
]
],
[
[
1668,
1,
770
],
[
770,
24,
1068
]
],
[
[
1668,
63,
79
],
[
79,
24,
1068
]
],
[
[
1668,
24,
1618
],
[
1618,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romosozumab"
]
],
[
[
"Lenalidomide",
"{u} (Compound) resembles {v} (Compound)",
"Thalidomide"
],
[
"Thalidomide",
"{u} may cause a ... | Lenalidomide (Compound) resembles Thalidomide (Compound) and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Romosozumab
Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that ... |
DB06718 | DB08827 | 1,687 | 990 | [
"DDInter1709",
"DDInter1085"
] | Stanozolol | Lomitapide | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1687,
25,
990
]
],
[
[
1687,
63,
322
],
[
322,
24,
990
]
],
[
[
1687,
64,
126
],
[
126,
24,
990
]
],
[
[
1687,
25,
350
],
[
350,
... | [
[
[
"Stanozolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[
"Epirubicin... | Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Stanozolol may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a mo... |
DB01246 | DB12332 | 820 | 1,619 | [
"DDInter45",
"DDInter1626"
] | Alimemazine | Rucaparib | A phenothiazine derivative that is used as an antipruritic. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
820,
24,
1619
]
],
[
[
820,
63,
222
],
[
222,
23,
1619
]
],
[
[
820,
62,
112
],
[
112,
23,
1619
]
],
[
[
820,
63,
1407
],
[
1407,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metr... |
DB00334 | DB09272 | 867 | 412 | [
"DDInter1326",
"DDInter632"
] | Olanzapine | Eluxadoline | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
867,
24,
412
]
],
[
[
867,
24,
1594
],
[
1594,
24,
412
]
],
[
[
867,
64,
475
],
[
475,
24,
412
]
],
[
[
867,
24,
407
],
[
407,
6... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Olanzapine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a m... |
DB00655 | DB01041 | 559 | 770 | [
"DDInter682",
"DDInter1789"
] | Estrone | Thalidomide | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
559,
25,
770
]
],
[
[
559,
64,
1668
],
[
1668,
1,
770
]
],
[
[
559,
6,
6365
],
[
6365,
45,
770
]
],
[
[
559,
21,
28921
],
[
28921,
... | [
[
[
"Estrone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Estrone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenalidomide"
],
[
"Lenalidomide",
"{u} (C... | Estrone may lead to a major life threatening interaction when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Estrone (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Estrone (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is ... |
DB01037 | DB08824 | 1,161 | 591 | [
"DDInter1653",
"DDInter959"
] | Selegiline | Ioflupane I-123 | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
1161,
24,
591
]
],
[
[
1161,
21,
29305
],
[
29305,
60,
591
]
],
[
[
1161,
24,
401
],
[
401,
24,
591
]
],
[
[
1161,
63,
999
],
[
999,
... | [
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Selegiline",
"{u} (Compound) causes {v} (Side Effect)",
"Dysgeusia"
],
[
"Dysgeusia",
"{u} (Side Effect) is... | Selegiline (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ioflupane I-123 (Compound)
Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00059 | DB00254 | 1,560 | 964 | [
"DDInter1404",
"DDInter598"
] | Pegaspargase | Doxycycline | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Moderate | 1 | [
[
[
1560,
24,
964
]
],
[
[
1560,
24,
1572
],
[
1572,
40,
964
]
],
[
[
1560,
24,
1620
],
[
1620,
1,
964
]
],
[
[
1560,
24,
45
],
[
45,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxycycline"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Doxycycline (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Tetracycline and Tetracycline (Compound) resembles Doxyc... |
DB00241 | DB00792 | 288 | 832 | [
"DDInter257",
"DDInter1878"
] | Butalbital | Tripelennamine | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
288,
24,
832
]
],
[
[
288,
24,
100
],
[
100,
63,
832
]
],
[
[
288,
24,
649
],
[
649,
1,
832
]
],
[
[
288,
24,
1594
],
[
1594,
24... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Clofeda... |
DB00477 | DB00782 | 216 | 1,123 | [
"DDInter363",
"DDInter1535"
] | Chlorpromazine | Propantheline | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
216,
24,
1123
]
],
[
[
216,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
216,
21,
28898
],
[
28898,
60,
1123
]
],
[
[
216,
24,
537
],
[
537,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Co... | Chlorpromazine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Chlorpromazine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB05679 | DB09570 | 1,683 | 1,480 | [
"DDInter1907",
"DDInter1002"
] | Ustekinumab | Ixazomib | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1683,
24,
1480
]
],
[
[
1683,
24,
987
],
[
987,
63,
1480
]
],
[
[
1683,
63,
268
],
[
268,
24,
1480
]
],
[
[
1683,
24,
1136
],
[
1136,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen and Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Ustekinumab may cause a moderate intera... |
DB00563 | DB00851 | 663 | 611 | [
"DDInter1174",
"DDInter463"
] | Methotrexate | Dacarbazine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
663,
24,
611
]
],
[
[
663,
5,
11555
],
[
11555,
44,
611
]
],
[
[
663,
6,
5542
],
[
5542,
45,
611
]
],
[
[
663,
18,
9650
],
[
9650,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Methotrexate",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (D... | Methotrexate (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dacarbazine (Compound)
Methotrexate (Compound) binds PGD (Gene) and PGD (Gene) is bound by Dacarbazine (Compound)
Methotrexate (Compound) downregulates HMGCS1 (Gene) and HMGCS1 (Gene) is downregulated by Dacarbazi... |
DB00924 | DB00981 | 1,405 | 1,528 | [
"DDInter454",
"DDInter1462"
] | Cyclobenzaprine | Physostigmine | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
1405,
24,
1528
]
],
[
[
1405,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
1405,
40,
508
],
[
508,
24,
1528
]
],
[
[
1405,
24,
1511
],
[
15... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Cyclobenzaprine",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side ... | Cyclobenzaprine (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Cyclobenzaprine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Cyclobenzaprine may cause a ... |
DB04951 | DB08827 | 187 | 990 | [
"DDInter1477",
"DDInter1085"
] | Pirfenidone | Lomitapide | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
187,
25,
990
]
],
[
[
187,
24,
1362
],
[
1362,
63,
990
]
],
[
[
187,
63,
752
],
[
752,
24,
990
]
],
[
[
187,
25,
1297
],
[
1297,
... | [
[
[
"Pirfenidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
"Olaparib",... | Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidi... |
DB00039 | DB01030 | 1,253 | 869 | [
"DDInter1380",
"DDInter1835"
] | Palifermin | Topotecan | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
1253,
24,
869
]
],
[
[
1253,
24,
613
],
[
613,
24,
869
]
],
[
[
1253,
24,
310
],
[
310,
63,
869
]
],
[
[
1253,
63,
1451
],
[
1451,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazi... |
DB01254 | DB01255 | 1,213 | 633 | [
"DDInter484",
"DDInter1078"
] | Dasatinib | Lisdexamfetamine | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
1213,
24,
633
]
],
[
[
1213,
21,
28751
],
[
28751,
60,
633
]
],
[
[
1213,
62,
112
],
[
112,
23,
633
]
],
[
[
1213,
63,
1494
],
[
1494,... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Dasatinib",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effect) i... | Dasatinib (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Lisdexamfetamine (Compound)
Dasatinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with... |
DB00060 | DB00065 | 912 | 581 | [
"DDInter947",
"DDInter923"
] | Interferon beta-1a | Infliximab | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions . Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory... | Moderate | 1 | [
[
[
912,
24,
581
]
],
[
[
912,
24,
33
],
[
33,
63,
581
]
],
[
[
912,
63,
1451
],
[
1451,
24,
581
]
],
[
[
912,
24,
250
],
[
250,
64,... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Infliximab"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Infliximab
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Inter... |
DB09075 | DB10672 | 498 | 297 | [
"DDInter621",
"DDInter417"
] | Edoxaban | Clove | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
498,
23,
297
]
],
[
[
498,
25,
235
],
[
235,
62,
297
]
],
[
[
498,
64,
578
],
[
578,
23,
297
]
],
[
[
498,
25,
235
],
[
235,
63,... | [
[
[
"Edoxaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
"{u}... | Edoxaban may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Edoxaban may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can... |
DB08870 | DB14409 | 850 | 1,129 | [
"DDInter228",
"DDInter867"
] | Brentuximab vedotin | Human adenovirus e serotype 4 strain cl-68578 antigen | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
850,
24,
1129
]
],
[
[
850,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
850,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
850,
24,
1468
],
[
1468,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Brentuximab vedotin",
"{u} may lead to a major life threatening interaction when taken... | Brentuximab vedotin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Brentuximab vedotin may cause a moderate interaction that could exacerbate ... |
DB01610 | DB06317 | 248 | 1,626 | [
"DDInter1912",
"DDInter630"
] | Valganciclovir | Elotuzumab | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
248,
24,
1626
]
],
[
[
248,
63,
973
],
[
973,
24,
1626
]
],
[
[
248,
24,
310
],
[
310,
63,
1626
]
],
[
[
248,
40,
563
],
[
563,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel a... |
DB00363 | DB01309 | 695 | 1,254 | [
"DDInter419",
"DDInter933"
] | Clozapine | Insulin glulisine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
695,
24,
1254
]
],
[
[
695,
25,
1621
],
[
1621,
23,
1254
]
],
[
[
695,
24,
274
],
[
274,
23,
1254
]
],
[
[
695,
25,
1424
],
[
1424,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
],
[
... | Clozapine may lead to a major life threatening interaction when taken with Potassium chloride and Potassium chloride may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamine and ... |
DB00661 | DB12015 | 122 | 1,033 | [
"DDInter1928",
"DDInter53"
] | Verapamil | Alpelisib | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
122,
24,
1033
]
],
[
[
122,
25,
1135
],
[
1135,
23,
1033
]
],
[
[
122,
24,
738
],
[
738,
24,
1033
]
],
[
[
122,
64,
467
],
[
467,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Verapamil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Verapamil may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderat... |
DB01156 | DB01168 | 593 | 1,053 | [
"DDInter252",
"DDInter1526"
] | Bupropion | Procarbazine | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Major | 2 | [
[
[
593,
25,
1053
]
],
[
[
593,
18,
4930
],
[
4930,
57,
1053
]
],
[
[
593,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
593,
64,
646
],
[
646,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
]
],
[
[
"Bupropion",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Bupropion (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Procarbazine (Compound)
Bupropion (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Bupropion may lead to a major life threatening interaction when taken with Cinoxacin and Cinoxacin m... |
DB00197 | DB11986 | 1,324 | 484 | [
"DDInter1881",
"DDInter648"
] | Troglitazone | Entrectinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1324,
24,
484
]
],
[
[
1324,
23,
271
],
[
271,
23,
484
]
],
[
[
1324,
24,
466
],
[
466,
62,
484
]
],
[
[
1324,
24,
1135
],
[
1135,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Dar... |
DB00964 | DB09488 | 1,617 | 103 | [
"DDInter110",
"DDInter23"
] | Apraclonidine | Acrivastine | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1617,
24,
103
]
],
[
[
1617,
24,
1264
],
[
1264,
24,
103
]
],
[
[
1617,
63,
104
],
[
104,
24,
103
]
],
[
[
1617,
25,
1053
],
[
1053,
... | [
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Met... |
DB01064 | DB01576 | 1,148 | 93 | [
"DDInter987",
"DDInter526"
] | Isoprenaline | Dextroamphetamine | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Dextroamphetamine is the dextrorotatory enantiomer of amphetamine. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label]. | Moderate | 1 | [
[
[
1148,
24,
93
]
],
[
[
1148,
63,
73
],
[
73,
1,
93
]
],
[
[
1148,
63,
80
],
[
80,
40,
93
]
],
[
[
1148,
24,
1529
],
[
1529,
40,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextroamphetamine"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine (Compound) resembles Dextroamphetamine (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Dextroa... |
DB00005 | DB00078 | 1,057 | 1,172 | [
"DDInter687",
"DDInter898"
] | Etanercept | Ibritumomab tiuxetan | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Major | 2 | [
[
[
1057,
25,
1172
]
],
[
[
1057,
24,
58
],
[
58,
63,
1172
]
],
[
[
1057,
25,
563
],
[
563,
63,
1172
]
],
[
[
1057,
25,
1184
],
[
1184,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibritumomab tiuxetan"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
"A... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Ibritumomab tiuxetan
Etanercept may lead to a major life threatening interaction when taken with Ganciclovir and Ganciclovir ... |
DB04896 | DB06764 | 901 | 1,090 | [
"DDInter1220",
"DDInter1787"
] | Milnacipran | Tetryzoline (nasal) | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
901,
24,
1090
]
],
[
[
901,
24,
144
],
[
144,
63,
1090
]
],
[
[
901,
63,
688
],
[
688,
24,
1090
]
],
[
[
901,
40,
41
],
[
41,
63... | [
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetryzoline"
]
],
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
],
[... | Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Milnac... |
DB00313 | DB01246 | 556 | 820 | [
"DDInter1913",
"DDInter45"
] | Valproic acid | Alimemazine | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
556,
24,
820
]
],
[
[
556,
24,
104
],
[
104,
40,
820
]
],
[
[
556,
24,
401
],
[
401,
24,
820
]
],
[
[
556,
24,
649
],
[
649,
1,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],... | Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interac... |
DB00635 | DB01136 | 1,573 | 772 | [
"DDInter1515",
"DDInter305"
] | Prednisone | Carvedilol | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
1573,
24,
772
]
],
[
[
1573,
6,
4973
],
[
4973,
45,
772
]
],
[
[
1573,
21,
28734
],
[
28734,
60,
772
]
],
[
[
1573,
23,
1283
],
[
1283... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Prednisone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Prednisone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carvedilol (Compound)
Prednisone (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Carvedilol (Compound)
Prednisone may cause a minor interaction that can limit clinical effects when taken wi... |
DB00350 | DB00902 | 1,214 | 104 | [
"DDInter1226",
"DDInter1168"
] | Minoxidil | Methdilazine | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1214,
24,
104
]
],
[
[
1214,
24,
820
],
[
820,
1,
104
]
],
[
[
1214,
24,
401
],
[
401,
63,
104
]
],
[
[
1214,
24,
1216
],
[
1216,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that... |
DB00543 | DB01124 | 87 | 1,411 | [
"DDInter82",
"DDInter1828"
] | Amoxapine | Tolbutamide | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
87,
24,
1411
]
],
[
[
87,
24,
959
],
[
959,
40,
1411
]
],
[
[
87,
63,
245
],
[
245,
40,
1411
]
],
[
[
87,
21,
29455
],
[
29455,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB01225 | DB04865 | 500 | 4 | [
"DDInter645",
"DDInter1335"
] | Enoxaparin | Omacetaxine mepesuccinate | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
500,
25,
4
]
],
[
[
500,
63,
305
],
[
305,
24,
4
]
],
[
[
500,
24,
738
],
[
738,
63,
4
]
],
[
[
500,
25,
39
],
[
39,
63,
4... | [
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Enoxaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia co... | Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Enoxaparin may cause a moderate interaction that could exac... |
DB00530 | DB12130 | 1,195 | 1,017 | [
"DDInter667",
"DDInter1094"
] | Erlotinib | Lorlatinib | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1195,
24,
1017
]
],
[
[
1195,
63,
1101
],
[
1101,
23,
1017
]
],
[
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1195,
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[
1491,
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]
],
[
[
1195,
63,
529
],
[
529... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Midostaur... |
DB00502 | DB01069 | 1,300 | 401 | [
"DDInter853",
"DDInter1533"
] | Haloperidol | Promethazine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Major | 2 | [
[
[
1300,
25,
401
]
],
[
[
1300,
25,
1264
],
[
1264,
63,
401
]
],
[
[
1300,
24,
649
],
[
649,
63,
401
]
],
[
[
1300,
24,
104
],
[
104,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
]
],
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
],
[
"Doxepin",
"{u} may... | Haloperidol may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a ... |
DB00191 | DB00197 | 73 | 1,324 | [
"DDInter1447",
"DDInter1881"
] | Phentermine | Troglitazone | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Moderate | 1 | [
[
[
73,
24,
1324
]
],
[
[
73,
63,
176
],
[
176,
24,
1324
]
],
[
[
73,
24,
506
],
[
506,
63,
1324
]
],
[
[
73,
36,
1529
],
[
1529,
63... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
]
],
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
]... | Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Dextr... |
DB00582 | DB00757 | 1,622 | 1,166 | [
"DDInter1946",
"DDInter581"
] | Voriconazole | Dolasetron | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
1622,
25,
1166
]
],
[
[
1622,
6,
6017
],
[
6017,
45,
1166
]
],
[
[
1622,
21,
28726
],
[
28726,
60,
1166
]
],
[
[
1622,
62,
752
],
[
75... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Dol... | Voriconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Dolasetron (Compound)
Voriconazole (Compound) causes Oliguria (Side Effect) and Oliguria (Side Effect) is caused by Dolasetron (Compound)
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Ci... |
DB00673 | DB01100 | 723 | 1,568 | [
"DDInter112",
"DDInter1470"
] | Aprepitant | Pimozide | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
723,
25,
1568
]
],
[
[
723,
64,
1557
],
[
1557,
25,
1568
]
],
[
[
723,
6,
7524
],
[
7524,
45,
1568
]
],
[
[
723,
21,
29024
],
[
29024,... | [
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Astemizole"
],
[
"Astemizole",
"{u} may... | Aprepitant may lead to a major life threatening interaction when taken with Astemizole and Astemizole may lead to a major life threatening interaction when taken with Pimozide
Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Pimozide (Compound)
Aprepitant (Compound) causes Hypertension (Side Effe... |
DB00022 | DB08870 | 268 | 850 | [
"DDInter1408",
"DDInter228"
] | Peginterferon alfa-2b | Brentuximab vedotin | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
268,
24,
850
]
],
[
[
268,
24,
788
],
[
788,
24,
850
]
],
[
[
268,
25,
1477
],
[
1477,
24,
850
]
],
[
[
268,
24,
1468
],
[
1468,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Peginterferon alfa-2b may lead to a major life threatening interaction when taken with T... |
DB01166 | DB14575 | 477 | 733 | [
"DDInter379",
"DDInter674"
] | Cilostazol | Eslicarbazepine | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
477,
24,
733
]
],
[
[
477,
63,
168
],
[
168,
23,
733
]
],
[
[
477,
63,
1264
],
[
1264,
24,
733
]
],
[
[
477,
24,
1491
],
[
1491,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepi... |
DB01045 | DB06595 | 463 | 1,491 | [
"DDInter1590",
"DDInter1214"
] | Rifampicin | Midostaurin | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
463,
25,
1491
]
],
[
[
463,
25,
1135
],
[
1135,
62,
1491
]
],
[
[
463,
63,
112
],
[
112,
23,
1491
]
],
[
[
463,
24,
761
],
[
761,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} ma... | Rifampicin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cau... |
DB00227 | DB00279 | 1,463 | 1,152 | [
"DDInter1098",
"DDInter1074"
] | Lovastatin | Liothyronine | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Minor | 0 | [
[
[
1463,
23,
1152
]
],
[
[
1463,
23,
542
],
[
542,
40,
1152
]
],
[
[
1463,
6,
6648
],
[
6648,
45,
1152
]
],
[
[
1463,
7,
8155
],
[
8155,
... | [
[
[
"Lovastatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Liothyronine"
]
],
[
[
"Lovastatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levothyroxine"
],
[
... | Lovastatin may cause a minor interaction that can limit clinical effects when taken with Levothyroxine and Levothyroxine (Compound) resembles Liothyronine (Compound)
Lovastatin (Compound) binds SLCO1A2 (Gene) and SLCO1A2 (Gene) is bound by Liothyronine (Compound)
Lovastatin (Compound) upregulates ABCC5 (Gene) and ABCC5... |
DB01218 | DB09118 | 1,493 | 1,580 | [
"DDInter852",
"DDInter1711"
] | Halofantrine | Stiripentol | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Major | 2 | [
[
[
1493,
25,
1580
]
],
[
[
1493,
25,
283
],
[
283,
63,
1580
]
],
[
[
1493,
64,
79
],
[
79,
24,
1580
]
],
[
[
1493,
25,
478
],
[
478,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stiripentol"
]
],
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"... | Halofantrine may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Halofantrine may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cause a moderate i... |
DB00685 | DB01261 | 1,299 | 170 | [
"DDInter1887",
"DDInter1679"
] | Trovafloxacin | Sitagliptin | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1299,
24,
170
]
],
[
[
1299,
21,
28850
],
[
28850,
60,
170
]
],
[
[
1299,
24,
52
],
[
52,
62,
170
]
],
[
[
1299,
64,
1179
],
[
1179,
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Back pain"
],
[
"Back pain",
"{u} (Side Effect) ... | Trovafloxacin (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with ... |
DB00557 | DB00581 | 252 | 355 | [
"DDInter895",
"DDInter1018"
] | Hydroxyzine | Lactulose | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
252,
24,
355
]
],
[
[
252,
24,
286
],
[
286,
62,
355
]
],
[
[
252,
63,
79
],
[
79,
24,
355
]
],
[
[
252,
25,
351
],
[
351,
63,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Lactulose
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Sora... |
DB00346 | DB00358 | 472 | 1,010 | [
"DDInter44",
"DDInter1140"
] | Alfuzosin | Mefloquine | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
472,
24,
1010
]
],
[
[
472,
6,
8374
],
[
8374,
45,
1010
]
],
[
[
472,
21,
28789
],
[
28789,
60,
1010
]
],
[
[
472,
23,
112
],
[
112,
... | [
[
[
"Alfuzosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Alfuzosin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Alfuzosin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound)
Alfuzosin (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Mefloquine (Compound)
Alfuzosin may cause a minor interaction that can limit clinical effects when taken with ... |
DB08881 | DB11986 | 868 | 484 | [
"DDInter1925",
"DDInter648"
] | Vemurafenib | Entrectinib | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
868,
25,
484
]
],
[
[
868,
62,
1247
],
[
1247,
23,
484
]
],
[
[
868,
23,
271
],
[
271,
23,
484
]
],
[
[
868,
24,
466
],
[
466,
6... | [
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Vemurafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sul... | Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Mirabegron a... |
DB00877 | DB01045 | 629 | 463 | [
"DDInter1678",
"DDInter1590"
] | Sirolimus | Rifampicin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Major | 2 | [
[
[
629,
25,
463
]
],
[
[
629,
64,
690
],
[
690,
40,
463
]
],
[
[
629,
6,
21998
],
[
21998,
45,
463
]
],
[
[
629,
7,
8155
],
[
8155,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rifampicin"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rifabutin"
],
[
"Rifabutin",
"{u} (Comp... | Sirolimus may lead to a major life threatening interaction when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Sirolimus (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Rifampicin (Compound)
Sirolimus (Compound) upregulates ABCC5 (Gene) and ABCC5 (Gene) is b... |
DB01261 | DB01320 | 170 | 651 | [
"DDInter1679",
"DDInter783"
] | Sitagliptin | Fosphenytoin | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
170,
24,
651
]
],
[
[
170,
63,
362
],
[
362,
1,
651
]
],
[
[
170,
6,
8374
],
[
8374,
45,
651
]
],
[
[
170,
21,
29360
],
[
29360,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Sitagliptin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Sitagliptin (Compound) causes Face oedema (Side Effect) and Fa... |
DB00834 | DB01259 | 932 | 392 | [
"DDInter1215",
"DDInter1024"
] | Mifepristone | Lapatinib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
932,
25,
392
]
],
[
[
932,
6,
4973
],
[
4973,
45,
392
]
],
[
[
932,
18,
10780
],
[
10780,
46,
392
]
],
[
[
932,
21,
29429
],
[
29429,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Mifepristone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lapati... | Mifepristone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Mifepristone (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is upregulated by Lapatinib (Compound)
Mifepristone (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (C... |
DB00850 | DB00986 | 1,630 | 1,192 | [
"DDInter1432",
"DDInter834"
] | Perphenazine | Glycopyrronium | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
1630,
24,
1192
]
],
[
[
1630,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
1630,
63,
262
],
[
262,
24,
1192
]
],
[
[
1630,
21,
29817
],
[
298... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium a... |
DB05273 | DB15091 | 507 | 676 | [
"DDInter1638",
"DDInter1901"
] | Samarium (153Sm) lexidronam | Upadacitinib | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
507,
25,
676
]
],
[
[
507,
63,
248
],
[
248,
24,
676
]
],
[
[
507,
25,
503
],
[
503,
25,
676
]
],
[
[
507,
64,
869
],
[
869,
25,... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valgan... | Samarium (153Sm) lexidronam may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Samarium (153Sm) lexidronam may lead to a major life threatening interaction when tak... |
DB00903 | DB01168 | 1,680 | 1,053 | [
"DDInter686",
"DDInter1526"
] | Etacrynic acid | Procarbazine | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1680,
24,
1053
]
],
[
[
1680,
24,
848
],
[
848,
40,
1053
]
],
[
[
1680,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1680,
63,
126
],
[
126... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Etacrynic acid (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Etacrynic acid may cause a moderate ... |
DB00418 | DB01285 | 536 | 708 | [
"DDInter1650",
"DDInter445"
] | Secobarbital | Corticotropin | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
536,
24,
708
]
],
[
[
536,
25,
126
],
[
126,
24,
708
]
],
[
[
536,
40,
697
],
[
697,
24,
708
]
],
[
[
536,
63,
1214
],
[
1214,
2... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Secobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warfa... | Secobarbital may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Secobarbital (Compound) resembles Phenobarbital (Compound) and Phenobarbital may cause a moderate interaction that could exace... |
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