drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00363 | DB08871 | 695 | 36 | [
"DDInter419",
"DDInter666"
] | Clozapine | Eribulin | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
695,
25,
36
]
],
[
[
695,
25,
1488
],
[
1488,
24,
36
]
],
[
[
695,
64,
599
],
[
599,
24,
36
]
],
[
[
695,
40,
867
],
[
867,
24,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludarabine"
],
[
"Fludarabine",
"{u} may... | Clozapine may lead to a major life threatening interaction when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Clozapine may lead to a major life threatening interaction when taken with Alemtuzumab and Alemtuzumab may cause a moderate inte... |
DB06207 | DB11827 | 910 | 433 | [
"DDInter1667",
"DDInter669"
] | Silodosin | Ertugliflozin | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
910,
24,
433
]
],
[
[
910,
63,
820
],
[
820,
24,
433
]
],
[
[
910,
64,
609
],
[
609,
24,
433
]
],
[
[
910,
24,
1033
],
[
1033,
6... | [
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Silodosin may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin... |
DB01050 | DB08880 | 848 | 1,510 | [
"DDInter900",
"DDInter1771"
] | Ibuprofen | Teriflunomide | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
848,
25,
1510
]
],
[
[
848,
24,
129
],
[
129,
63,
1510
]
],
[
[
848,
63,
1144
],
[
1144,
24,
1510
]
],
[
[
848,
25,
279
],
[
279,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
"Enzalut... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and ... |
DB00420 | DB11718 | 508 | 927 | [
"DDInter1532",
"DDInter640"
] | Promazine | Encorafenib | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
508,
24,
927
]
],
[
[
508,
23,
112
],
[
112,
23,
927
]
],
[
[
508,
24,
720
],
[
720,
24,
927
]
],
[
[
508,
40,
216
],
[
216,
24,... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Promazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Promazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and Mine... |
DB01136 | DB05812 | 772 | 1,374 | [
"DDInter305",
"DDInter8"
] | Carvedilol | Abiraterone | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
772,
24,
1374
]
],
[
[
772,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
772,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
772,
24,
760
],
[
760,... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Carvedilol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Carvedilol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Carvedilol (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat ... |
DB00261 | DB00862 | 702 | 1,005 | [
"DDInter93",
"DDInter1918"
] | Anagrelide | Vardenafil | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Major | 2 | [
[
[
702,
25,
1005
]
],
[
[
702,
21,
28988
],
[
28988,
60,
1005
]
],
[
[
702,
23,
112
],
[
112,
63,
1005
]
],
[
[
702,
25,
1494
],
[
1494,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vardenafil"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Amnesia"
],
[
"Amnesia",
"{u} (Side Effect) is caused by {v} (Compound... | Anagrelide (Compound) causes Amnesia (Side Effect) and Amnesia (Side Effect) is caused by Vardenafil (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Vardena... |
DB00014 | DB00382 | 521 | 62 | [
"DDInter839",
"DDInter1734"
] | Goserelin | Tacrine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Moderate | 1 | [
[
[
521,
24,
62
]
],
[
[
521,
24,
79
],
[
79,
63,
62
]
],
[
[
521,
25,
11
],
[
11,
63,
62
]
],
[
[
521,
25,
702
],
[
702,
24,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tacrine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
"S... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Tacrine
Goserelin may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moder... |
DB00467 | DB09322 | 1,467 | 1,114 | [
"DDInter644",
"DDInter1966"
] | Enoxacin | Zinc sulfate | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Moderate | 1 | [
[
[
1467,
24,
1114
]
],
[
[
1467,
64,
251
],
[
251,
23,
1114
]
],
[
[
1467,
23,
1307
],
[
1307,
23,
1114
]
],
[
[
1467,
25,
891
],
[
891,
... | [
[
[
"Enoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betamethasone"
],
[
"Betametha... | Enoxacin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Enoxacin may cause a minor interaction that can limit clinical effects when taken with Melphalan and Melphalan may cause a ... |
DB01211 | DB04845 | 609 | 309 | [
"DDInter393",
"DDInter1001"
] | Clarithromycin | Ixabepilone | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
609,
24,
309
]
],
[
[
609,
6,
8374
],
[
8374,
45,
309
]
],
[
[
609,
21,
28987
],
[
28987,
60,
309
]
],
[
[
609,
62,
307
],
[
307,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Clarithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Clarithromycin (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Modafinil and... |
DB00544 | DB01097 | 970 | 1,377 | [
"DDInter757",
"DDInter1033"
] | Fluorouracil | Leflunomide | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
970,
25,
1377
]
],
[
[
970,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
970,
21,
28701
],
[
28701,
60,
1377
]
],
[
[
970,
63,
1461
],
[
1461,... | [
[
[
"Fluorouracil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Fluorouracil",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Le... | Fluorouracil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Fluorouracil (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Leflunomide (Compound)
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E... |
DB00877 | DB04868 | 629 | 478 | [
"DDInter1678",
"DDInter1293"
] | Sirolimus | Nilotinib | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
629,
24,
478
]
],
[
[
629,
24,
1468
],
[
1468,
63,
478
]
],
[
[
629,
6,
4973
],
[
4973,
45,
478
]
],
[
[
629,
7,
6732
],
[
6732,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Sirolimus (Compound) upreg... |
DB00285 | DB08865 | 1,100 | 1,593 | [
"DDInter1927",
"DDInter448"
] | Venlafaxine | Crizotinib | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
1100,
25,
1593
]
],
[
[
1100,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1100,
21,
28771
],
[
28771,
60,
1593
]
],
[
[
1100,
24,
283
],
[
28... | [
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Venlafaxine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizo... | Venlafaxine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Venlafaxine (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Crizotinib (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB14723 | DB15093 | 159 | 1,654 | [
"DDInter1026",
"DDInter1698"
] | Larotrectinib | Somapacitan | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
159,
24,
1654
]
],
[
[
159,
63,
608
],
[
608,
23,
1654
]
],
[
[
159,
62,
1135
],
[
1135,
24,
1654
]
],
[
[
159,
63,
351
],
[
351,
... | [
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Larotrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
... | Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Larotrectinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxe... |
DB01097 | DB01285 | 1,377 | 708 | [
"DDInter1033",
"DDInter445"
] | Leflunomide | Corticotropin | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Major | 2 | [
[
[
1377,
25,
708
]
],
[
[
1377,
63,
245
],
[
245,
24,
708
]
],
[
[
1377,
25,
155
],
[
155,
24,
708
]
],
[
[
1377,
24,
1411
],
[
1411,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Corticotropin"
]
],
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
"Glim... | Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Leflunomide may lead to a major life threatening interaction when taken with Fluoxymesterone and Fluoxymes... |
DB00220 | DB11978 | 798 | 124 | [
"DDInter1276",
"DDInter822"
] | Nelfinavir | Glasdegib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
798,
25,
124
]
],
[
[
798,
25,
1135
],
[
1135,
23,
124
]
],
[
[
798,
24,
466
],
[
466,
62,
124
]
],
[
[
798,
24,
26
],
[
26,
24,... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Nelfinavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a... |
DB00775 | DB06209 | 1,226 | 256 | [
"DDInter1818",
"DDInter1508"
] | Tirofiban | Prasugrel | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
1226,
25,
256
]
],
[
[
1226,
54,
19166
],
[
19166,
15,
256
]
],
[
[
1226,
21,
28681
],
[
28681,
60,
256
]
],
[
[
1226,
23,
944
],
[
94... | [
[
[
"Tirofiban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Tirofiban",
"{u} (Compound) is included by {v} (Pharmacologic Class)",
"Decreased Platelet Aggregation"
],
[
"Decreased Platelet Aggreg... | Tirofiban (Compound) is included by Decreased Platelet Aggregation (Pharmacologic Class) and Decreased Platelet Aggregation (Pharmacologic Class) includes Prasugrel (Compound)
Tirofiban (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Prasugrel (Compound)
Tirofiban may ca... |
DB00557 | DB00816 | 252 | 1,674 | [
"DDInter895",
"DDInter1346"
] | Hydroxyzine | Orciprenaline | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
252,
24,
1674
]
],
[
[
252,
21,
28681
],
[
28681,
60,
1674
]
],
[
[
252,
63,
618
],
[
618,
24,
1674
]
],
[
[
252,
24,
484
],
[
484,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (S... | Hydroxyzine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Orciprenaline (Compound)
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Abarelix and Abarelix may cause a moderate interaction that could exacerbate diseases when tak... |
DB09237 | DB14724 | 1,586 | 48 | [
"DDInter1045",
"DDInter634"
] | Levamlodipine | Emapalumab | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
1586,
24,
48
]
],
[
[
1586,
63,
1409
],
[
1409,
24,
48
]
],
[
[
1586,
64,
467
],
[
467,
24,
48
]
],
[
[
1586,
63,
1409
],
[
1409,
... | [
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
],
... | Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Levamlodipine may lead to a major life threatening interaction when taken with Simvastatin and Simvastatin may ca... |
DB05812 | DB11986 | 1,374 | 484 | [
"DDInter8",
"DDInter648"
] | Abiraterone | Entrectinib | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1374,
24,
484
]
],
[
[
1374,
62,
1247
],
[
1247,
23,
484
]
],
[
[
1374,
23,
466
],
[
466,
62,
484
]
],
[
[
1374,
23,
1135
],
[
1135,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide... |
DB01166 | DB04896 | 477 | 901 | [
"DDInter379",
"DDInter1220"
] | Cilostazol | Milnacipran | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
477,
24,
901
]
],
[
[
477,
24,
41
],
[
41,
1,
901
]
],
[
[
477,
18,
5901
],
[
5901,
57,
901
]
],
[
[
477,
21,
29269
],
[
29269,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Cilostazol (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Milnacipran (Compound)
Cilostazol (Compound) causes Menopausal sy... |
DB00407 | DB12500 | 202 | 283 | [
"DDInter115",
"DDInter714"
] | Ardeparin | Fedratinib | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
202,
25,
283
]
],
[
[
202,
25,
885
],
[
885,
24,
283
]
],
[
[
202,
24,
557
],
[
557,
24,
283
]
],
[
[
202,
64,
1018
],
[
1018,
2... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
],
[
"Epoprostenol",
"{u}... | Ardeparin may lead to a major life threatening interaction when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Ardeparin may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid and Deoxycholic a... |
DB01101 | DB10583 | 60 | 949 | [
"DDInter285",
"DDInter415"
] | Capecitabine | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
60,
24,
949
]
],
[
[
60,
63,
589
],
[
589,
24,
949
]
],
[
[
60,
64,
1377
],
[
1377,
24,
949
]
],
[
[
60,
25,
1259
],
[
1259,
63,... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases wh... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Capecitabine may lead to a major life threatening interaction ... |
DB08895 | DB11627 | 976 | 1,367 | [
"DDInter1825",
"DDInter860"
] | Tofacitinib | Hepatitis B Vaccine (Recombinant) | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
976,
24,
1367
]
],
[
[
976,
64,
1083
],
[
1083,
24,
1367
]
],
[
[
976,
25,
1480
],
[
1480,
24,
1367
]
],
[
[
976,
25,
119
],
[
119,
... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluridine"
... | Tofacitinib may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Tofacitinib may lead to a major life threatening interaction when taken with Ixazomib and Ixazomib ... |
DB00348 | DB08912 | 254 | 1,040 | [
"DDInter1300",
"DDInter462"
] | Nitisinone | Dabrafenib | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
254,
24,
1040
]
],
[
[
254,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
254,
63,
1101
],
[
1101,
23,
1040
]
],
[
[
254,
24,
478
],
[
478,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effec... | Nitisinone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with... |
DB06414 | DB12332 | 655 | 1,619 | [
"DDInter703",
"DDInter1626"
] | Etravirine | Rucaparib | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
655,
24,
1619
]
],
[
[
655,
63,
222
],
[
222,
23,
1619
]
],
[
[
655,
24,
1135
],
[
1135,
23,
1619
]
],
[
[
655,
63,
309
],
[
309,
... | [
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Etravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Etravirine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxego... |
DB00502 | DB00902 | 1,300 | 104 | [
"DDInter853",
"DDInter1168"
] | Haloperidol | Methdilazine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1300,
24,
104
]
],
[
[
1300,
63,
13
],
[
13,
24,
104
]
],
[
[
1300,
25,
820
],
[
820,
1,
104
]
],
[
[
1300,
24,
537
],
[
537,
40... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Haloperidol may lead to a major life threatening interaction when taken with Alimemazine and Alimemaz... |
DB00261 | DB00358 | 702 | 1,010 | [
"DDInter93",
"DDInter1140"
] | Anagrelide | Mefloquine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Major | 2 | [
[
[
702,
25,
1010
]
],
[
[
702,
18,
2183
],
[
2183,
57,
1010
]
],
[
[
702,
21,
28789
],
[
28789,
60,
1010
]
],
[
[
702,
23,
112
],
[
112,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mefloquine"
]
],
[
[
"Anagrelide",
"{u} (Compound) downregulates {v} (Gene)",
"CDC20"
],
[
"CDC20",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Anagrelide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Mefloquine (Compound)
Anagrelide (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Mefloquine (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects... |
DB01225 | DB09068 | 500 | 1,427 | [
"DDInter645",
"DDInter1948"
] | Enoxaparin | Vortioxetine | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
500,
24,
1427
]
],
[
[
500,
64,
25
],
[
25,
24,
1427
]
],
[
[
500,
25,
256
],
[
256,
24,
1427
]
],
[
[
500,
25,
405
],
[
405,
63... | [
[
[
"Enoxaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
"Anistr... | Enoxaparin may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Enoxaparin may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a moderate ... |
DB00691 | DB08907 | 1,058 | 1,344 | [
"DDInter1237",
"DDInter280"
] | Moexipril | Canagliflozin | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1058,
24,
1344
]
],
[
[
1058,
24,
549
],
[
549,
1,
1344
]
],
[
[
1058,
24,
1486
],
[
1486,
24,
1344
]
],
[
[
1058,
63,
176
],
[
176,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a moderate... |
DB00283 | DB00899 | 701 | 411 | [
"DDInter395",
"DDInter1579"
] | Clemastine | Remifentanil | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Moderate | 1 | [
[
[
701,
24,
411
]
],
[
[
701,
24,
1322
],
[
1322,
40,
411
]
],
[
[
701,
24,
704
],
[
704,
1,
411
]
],
[
[
701,
21,
28691
],
[
28691,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and Alfentanil (Compound) resembles Remifentanil (Compound)
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Remifentanil (Compound)
... |
DB00060 | DB01048 | 912 | 764 | [
"DDInter947",
"DDInter1"
] | Interferon beta-1a | Abacavir | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir. | Moderate | 1 | [
[
[
912,
24,
764
]
],
[
[
912,
24,
1064
],
[
1064,
24,
764
]
],
[
[
912,
63,
1560
],
[
1560,
24,
764
]
],
[
[
912,
24,
1142
],
[
1142,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abacavir"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cladribine"
... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Cladribine and Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Abacavir
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Pegaspa... |
DB00690 | DB00748 | 1,216 | 662 | [
"DDInter762",
"DDInter297"
] | Flurazepam | Carbinoxamine | A benzodiazepine derivative used mainly as a hypnotic. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
1216,
24,
662
]
],
[
[
1216,
63,
1594
],
[
1594,
24,
662
]
],
[
[
1216,
40,
216
],
[
216,
24,
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]
],
[
[
1216,
40,
11275
],
[
11275,... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[... | Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Flurazepam (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause a moderate interaction... |
DB01142 | DB06716 | 1,264 | 142 | [
"DDInter593",
"DDInter784"
] | Doxepin | Fospropofol | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Fospropofol is a water soluble prodrug and is converted to propofol in the liver. Fospropofol is a short acting hypnotic/sedative/anesthetic agent. Unlike propofol, does not cause injection-site pain as it is unable to activate TRPA1. FDA approved in December 2008. Fospropofol is a Schedule IV controlled substance in t... | Moderate | 1 | [
[
[
1264,
24,
142
]
],
[
[
1264,
63,
898
],
[
898,
1,
142
]
],
[
[
1264,
21,
28666
],
[
28666,
60,
142
]
],
[
[
1264,
63,
475
],
[
475,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fospropofol"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propofol"
],
[
"Pr... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Propofol and Propofol (Compound) resembles Fospropofol (Compound)
Doxepin (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Fospropofol (Compound)
Doxepin may cause a mode... |
DB12010 | DB15093 | 214 | 1,654 | [
"DDInter785",
"DDInter1698"
] | Fostamatinib | Somapacitan | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA. Recently, fosta... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
214,
24,
1654
]
],
[
[
214,
63,
608
],
[
608,
23,
1654
]
],
[
[
214,
63,
10
],
[
10,
24,
1654
]
],
[
[
214,
24,
159
],
[
159,
24... | [
[
[
"Fostamatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Fostamatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
... | Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone ... |
DB00656 | DB11730 | 827 | 351 | [
"DDInter1851",
"DDInter1588"
] | Trazodone | Ribociclib | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
827,
24,
351
]
],
[
[
827,
23,
112
],
[
112,
23,
351
]
],
[
[
827,
25,
222
],
[
222,
23,
351
]
],
[
[
827,
24,
283
],
[
283,
62,... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Trazodone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Trazodone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Trazodone may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may caus... |
DB00536 | DB00986 | 1,225 | 1,192 | [
"DDInter848",
"DDInter834"
] | Guanidine | Glycopyrronium | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
1225,
24,
1192
]
],
[
[
1225,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
1225,
24,
262
],
[
262,
24,
1192
]
],
[
[
1225,
21,
28900
],
[
289... | [
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[... | Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Cli... |
DB00280 | DB00281 | 494 | 608 | [
"DDInter575",
"DDInter1066"
] | Disopyramide | Lidocaine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anes... | Moderate | 1 | [
[
[
494,
24,
608
]
],
[
[
494,
6,
7953
],
[
7953,
45,
608
]
],
[
[
494,
21,
28722
],
[
28722,
60,
608
]
],
[
[
494,
24,
1101
],
[
1101,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"SCN5A"
],
[
"SCN5A",
"{u} (Gene) is bound by {v} (Compound)"... | Disopyramide (Compound) binds SCN5A (Gene) and SCN5A (Gene) is bound by Lidocaine (Compound)
Disopyramide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lidocaine (Compound)
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarote... |
DB00496 | DB08897 | 194 | 1,429 | [
"DDInter480",
"DDInter22"
] | Darifenacin | Aclidinium | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
194,
24,
1429
]
],
[
[
194,
74,
352
],
[
352,
24,
1429
]
],
[
[
194,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
194,
35,
262
],
[
262,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Darifenacin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken... | Darifenacin (Compound) resembles Trospium (Compound) and Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Darifenacin may cause a moderate interaction that could ex... |
DB00322 | DB10429 | 141 | 200 | [
"DDInter742",
"DDInter282"
] | Floxuridine | Candida albicans | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
141,
24,
200
]
],
[
[
141,
24,
1683
],
[
1683,
24,
200
]
],
[
[
141,
25,
976
],
[
976,
24,
200
]
],
[
[
141,
1,
1083
],
[
1083,
... | [
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Floxuridine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitini... |
DB00321 | DB01211 | 21 | 609 | [
"DDInter78",
"DDInter393"
] | Amitriptyline | Clarithromycin | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
21,
24,
609
]
],
[
[
21,
6,
4973
],
[
4973,
45,
609
]
],
[
[
21,
21,
28662
],
[
28662,
60,
609
]
],
[
[
21,
63,
600
],
[
600,
23... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Com... | Amitriptyline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Amitriptyline (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Fluconazol... |
DB00951 | DB06273 | 1,072 | 980 | [
"DDInter986",
"DDInter1824"
] | Isoniazid | Tocilizumab | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1072,
24,
980
]
],
[
[
1072,
24,
309
],
[
309,
24,
980
]
],
[
[
1072,
24,
850
],
[
850,
63,
980
]
],
[
[
1072,
63,
1031
],
[
1031,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin ... |
DB00637 | DB06288 | 1,557 | 607 | [
"DDInter128",
"DDInter77"
] | Astemizole | Amisulpride | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Major | 2 | [
[
[
1557,
25,
607
]
],
[
[
1557,
23,
112
],
[
112,
23,
607
]
],
[
[
1557,
24,
1559
],
[
1559,
24,
607
]
],
[
[
1557,
25,
1383
],
[
1383,
... | [
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amisulpride"
]
],
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Astemizole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Amisulpride
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Fam... |
DB00008 | DB14783 | 491 | 287 | [
"DDInter1407",
"DDInter574"
] | Peginterferon alfa-2a | Diroximel fumarate | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
491,
24,
287
]
],
[
[
491,
25,
1101
],
[
1101,
24,
287
]
],
[
[
491,
24,
1560
],
[
1560,
24,
287
]
],
[
[
491,
23,
450
],
[
450,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
... | Peginterferon alfa-2a may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Pegasp... |
DB01059 | DB01073 | 956 | 1,488 | [
"DDInter1313",
"DDInter745"
] | Norfloxacin | Fludarabine | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Minor | 0 | [
[
[
956,
23,
1488
]
],
[
[
956,
62,
372
],
[
372,
1,
1488
]
],
[
[
956,
21,
29106
],
[
29106,
60,
1488
]
],
[
[
956,
40,
1539
],
[
1539,
... | [
[
[
"Norfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludarabine"
]
],
[
[
"Norfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clofarabine"
],
[
... | Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Norfloxacin (Compound) causes Myalgia (Side Effect) and Myalgia (Side Effect) is caused by Fludarabine (Compound)
Norfloxacin (Compound) resembles Ofloxacin (... |
DB00421 | DB06822 | 443 | 802 | [
"DDInter1707",
"DDInter1812"
] | Spironolactone | Tinzaparin | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
443,
24,
802
]
],
[
[
443,
24,
222
],
[
222,
24,
802
]
],
[
[
443,
24,
738
],
[
738,
63,
802
]
],
[
[
443,
24,
1409
],
[
1409,
2... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Niraparib a... |
DB00816 | DB01268 | 1,674 | 1,151 | [
"DDInter1346",
"DDInter1731"
] | Orciprenaline | Sunitinib | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
1674,
24,
1151
]
],
[
[
1674,
18,
16549
],
[
16549,
46,
1151
]
],
[
[
1674,
21,
28642
],
[
28642,
60,
1151
]
],
[
[
1674,
35,
1148
],
[
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Orciprenaline",
"{u} (Compound) downregulates {v} (Gene)",
"SLC2A6"
],
[
"SLC2A6",
"{u} (Gene) is upregulated ... | Orciprenaline (Compound) downregulates SLC2A6 (Gene) and SLC2A6 (Gene) is upregulated by Sunitinib (Compound)
Orciprenaline (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Sunitinib (Compound)
Orciprenaline (Compound) resembles Isoprenaline (Compound) and Orciprenaline may cause a moderate in... |
DB00196 | DB00348 | 600 | 254 | [
"DDInter743",
"DDInter1300"
] | Fluconazole | Nitisinone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Moderate | 1 | [
[
[
600,
24,
254
]
],
[
[
600,
21,
29224
],
[
29224,
60,
254
]
],
[
[
600,
23,
307
],
[
307,
62,
254
]
],
[
[
600,
24,
1144
],
[
1144,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitisinone"
]
],
[
[
"Fluconazole",
"{u} (Compound) causes {v} (Side Effect)",
"Rash erythematous"
],
[
"Rash erythematous",
"{u} (Si... | Fluconazole (Compound) causes Rash erythematous (Side Effect) and Rash erythematous (Side Effect) is caused by Nitisinone (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken ... |
DB01396 | DB08868 | 1,482 | 1,011 | [
"DDInter553",
"DDInter737"
] | Digitoxin | Fingolimod | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1482,
25,
1011
]
],
[
[
1482,
6,
8374
],
[
8374,
45,
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],
[
[
1482,
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],
[
1276,
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]
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[
[
1482,
62,
752
],
[
752,... | [
[
[
"Digitoxin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Digitoxin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingolimo... | Digitoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Alectinib and Alectinib may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Digitoxin may cause a ... |
DB00467 | DB01206 | 1,467 | 37 | [
"DDInter644",
"DDInter1086"
] | Enoxacin | Lomustine | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | An alkylating agent of value against both hematologic malignancies and solid tumors. | Minor | 0 | [
[
[
1467,
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37
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],
[
[
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[
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[
956,
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[
[
1467,
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147
],
[
147,
2... | [
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomustine"
]
],
[
[
"Enoxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may cause a minor inte... | Enoxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Lomustine
Enoxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Lomustine
Enox... |
DB01006 | DB09098 | 300 | 98 | [
"DDInter1040",
"DDInter1700"
] | Letrozole | Somatrem | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
300,
24,
98
]
],
[
[
300,
24,
1671
],
[
1671,
24,
98
]
],
[
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300,
24,
159
],
[
159,
63,
98
]
],
[
[
300,
62,
307
],
[
307,
24,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
],
[
... | Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB01156 | DB01234 | 593 | 1,220 | [
"DDInter252",
"DDInter513"
] | Bupropion | Dexamethasone | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Major | 2 | [
[
[
593,
25,
1220
]
],
[
[
593,
64,
870
],
[
870,
1,
1220
]
],
[
[
593,
64,
175
],
[
175,
40,
1220
]
],
[
[
593,
6,
6017
],
[
6017,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
]
],
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludrocortisone"
],
[
"Fludrocortisone",
... | Bupropion may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Bupropion may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Bupropion ... |
DB00218 | DB00762 | 1,176 | 613 | [
"DDInter1247",
"DDInter973"
] | Moxifloxacin | Irinotecan | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Minor | 0 | [
[
[
1176,
23,
613
]
],
[
[
1176,
23,
869
],
[
869,
63,
613
]
],
[
[
1176,
6,
3199
],
[
3199,
57,
613
]
],
[
[
1176,
21,
28675
],
[
28675,
... | [
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Irinotecan"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Topotecan"
],
[
... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan
Moxifloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Irinotecan (Compound)
Moxifloxacin... |
DB05015 | DB12015 | 1,077 | 1,033 | [
"DDInter174",
"DDInter53"
] | Belinostat | Alpelisib | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
1077,
24,
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]
],
[
[
1077,
24,
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],
[
738,
24,
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],
[
[
1077,
25,
1510
],
[
1510,
24,
1033
]
],
[
[
1077,
63,
869
],
[
869,
... | [
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
[
... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Belinostat may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cau... |
DB00281 | DB05679 | 608 | 1,683 | [
"DDInter1066",
"DDInter1907"
] | Lidocaine | Ustekinumab | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
608,
24,
1683
]
],
[
[
608,
35,
1401
],
[
1401,
24,
1683
]
],
[
[
608,
24,
1362
],
[
1362,
63,
1683
]
],
[
[
608,
24,
33
],
[
33,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Lidocaine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken wi... | Lidocaine (Compound) resembles Procainamide (Compound) and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Procainamide and Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Lidocaine may cause a moderate interaction that c... |
DB00572 | DB04908 | 85 | 1,671 | [
"DDInter136",
"DDInter741"
] | Atropine | Flibanserin | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
85,
24,
1671
]
],
[
[
85,
24,
830
],
[
830,
24,
1671
]
],
[
[
85,
63,
1594
],
[
1594,
24,
1671
]
],
[
[
85,
24,
407
],
[
407,
63... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
],
[
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxyl... |
DB01172 | DB09134 | 416 | 1,552 | [
"DDInter1004",
"DDInter966"
] | Kanamycin | Ioversol | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
416,
25,
1552
]
],
[
[
416,
23,
699
],
[
699,
24,
1552
]
],
[
[
416,
24,
242
],
[
242,
63,
1552
]
],
[
[
416,
64,
1028
],
[
1028,
... | [
[
[
"Kanamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Kanamycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nadolol"
],
[
"Nadolol",
"{u... | Kanamycin may cause a minor interaction that can limit clinical effects when taken with Nadolol and Nadolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cau... |
DB01176 | DB01200 | 537 | 469 | [
"DDInter453",
"DDInter243"
] | Cyclizine | Bromocriptine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
537,
24,
469
]
],
[
[
537,
21,
28692
],
[
28692,
60,
469
]
],
[
[
537,
63,
401
],
[
401,
24,
469
]
],
[
[
537,
74,
1376
],
[
1376,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Cyclizine",
"{u} (Compound) causes {v} (Side Effect)",
"Mental disorder"
],
[
"Mental disorder",
"{u} (Side Ef... | Cyclizine (Compound) causes Mental disorder (Side Effect) and Mental disorder (Side Effect) is caused by Bromocriptine (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when t... |
DB06636 | DB06772 | 1,623 | 310 | [
"DDInter980",
"DDInter259"
] | Isavuconazonium | Cabazitaxel | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
1623,
24,
310
]
],
[
[
1623,
63,
973
],
[
973,
24,
310
]
],
[
[
1623,
24,
868
],
[
868,
63,
310
]
],
[
[
1623,
25,
913
],
[
913,
... | [
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
... | Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Vemurafeni... |
DB00461 | DB00761 | 598 | 1,621 | [
"DDInter1254",
"DDInter1497"
] | Nabumetone | Potassium chloride | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Moderate | 1 | [
[
[
598,
24,
1621
]
],
[
[
598,
21,
28809
],
[
28809,
60,
1621
]
],
[
[
598,
24,
1512
],
[
1512,
24,
1621
]
],
[
[
598,
24,
848
],
[
848,
... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium chloride"
]
],
[
[
"Nabumetone",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect)... | Nabumetone (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00843 | DB13074 | 479 | 877 | [
"DDInter583",
"DDInter1110"
] | Donepezil | Macimorelin | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Moderate | 1 | [
[
[
479,
24,
877
]
],
[
[
479,
24,
112
],
[
112,
23,
877
]
],
[
[
479,
24,
1320
],
[
1320,
24,
877
]
],
[
[
479,
63,
85
],
[
85,
24,... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macimorelin"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elago... |
DB01244 | DB09112 | 762 | 1,455 | [
"DDInter192",
"DDInter1306"
] | Bepridil | Nitrous acid | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
762,
24,
1455
]
],
[
[
762,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
762,
1,
601
],
[
601,
24,
1455
]
],
[
[
762,
63,
885
],
[
885,
... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[
... | Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Bepridil (Compound) resembles Trimethaphan (Compound) and Trimethaphan may cause a moderate interaction th... |
DB00059 | DB00207 | 1,560 | 1,570 | [
"DDInter1404",
"DDInter157"
] | Pegaspargase | Azithromycin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually t... | Moderate | 1 | [
[
[
1560,
24,
1570
]
],
[
[
1560,
24,
1056
],
[
1056,
1,
1570
]
],
[
[
1560,
24,
609
],
[
609,
63,
1570
]
],
[
[
1560,
24,
912
],
[
912,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
],... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Telithromycin and Telithromycin (Compound) resembles Azithromycin (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate in... |
DB00586 | DB09413 | 1,512 | 1,203 | [
"DDInter537",
"DDInter1241"
] | Diclofenac | Monopotassium phosphate | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia b... | Moderate | 1 | [
[
[
1512,
24,
1203
]
],
[
[
1512,
24,
1274
],
[
1274,
24,
1203
]
],
[
[
1512,
24,
1274
],
[
1274,
35,
848
],
[
848,
24,
1203
]
],
[
[
1512... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Monopotassium phosphate"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Monopotassium phosphate
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Flur... |
DB06410 | DB12332 | 1,196 | 1,619 | [
"DDInter595",
"DDInter1626"
] | Doxercalciferol | Rucaparib | Doxercalciferol is a synthetic vitamin D2 analog that undergoes metabolic activation in vivo to form 1α,25-dihydroxyvitamin D2 (1α,25-(OH)2D2), a naturally occurring, biologically active form of vitamin D2. Doxercalciferol is indicated for the treatment of secondary hyperparathyroidism in patients with chronic kidney d... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1196,
24,
1619
]
],
[
[
1196,
24,
98
],
[
98,
24,
1619
]
],
[
[
1196,
63,
651
],
[
651,
24,
1619
]
],
[
[
1196,
24,
1654
],
[
1654,
... | [
[
[
"Doxercalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Doxercalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
],
... | Doxercalciferol may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Doxercalciferol may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and... |
DB06788 | DB09045 | 1,616 | 52 | [
"DDInter864",
"DDInter607"
] | Histrelin | Dulaglutide | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1616,
24,
52
]
],
[
[
1616,
63,
170
],
[
170,
23,
52
]
],
[
[
1616,
63,
609
],
[
609,
24,
52
]
],
[
[
1616,
64,
1154
],
[
1154,
... | [
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Histrelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
... | Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Histrelin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Cla... |
DB00572 | DB00881 | 85 | 954 | [
"DDInter136",
"DDInter1554"
] | Atropine | Quinapril | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
85,
24,
954
]
],
[
[
85,
24,
1523
],
[
1523,
40,
954
]
],
[
[
85,
24,
675
],
[
675,
1,
954
]
],
[
[
85,
21,
28763
],
[
28763,
60... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
"L... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Quinapril (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Quinapril (Co... |
DB00694 | DB11837 | 51 | 1,297 | [
"DDInter486",
"DDInter1351"
] | Daunorubicin (liposomal) | Osilodrostat | Daunomycin can cause cancer according to an independent committee of scientific and health experts. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
51,
24,
1297
]
],
[
[
51,
23,
112
],
[
112,
23,
1297
]
],
[
[
51,
24,
466
],
[
466,
62,
1297
]
],
[
[
51,
24,
1320
],
[
1320,
63... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
... |
DB00334 | DB04837 | 867 | 649 | [
"DDInter1326",
"DDInter407"
] | Olanzapine | Clofedanol | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
867,
24,
649
]
],
[
[
867,
24,
1376
],
[
1376,
24,
649
]
],
[
[
867,
24,
832
],
[
832,
40,
649
]
],
[
[
867,
63,
701
],
[
701,
2... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennam... |
DB00445 | DB09061 | 322 | 1,627 | [
"DDInter655",
"DDInter284"
] | Epirubicin | Cannabidiol | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
322,
24,
1627
]
],
[
[
322,
24,
609
],
[
609,
23,
1627
]
],
[
[
322,
63,
600
],
[
600,
23,
1627
]
],
[
[
322,
25,
351
],
[
351,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB00022 | DB08826 | 268 | 1,292 | [
"DDInter1408",
"DDInter489"
] | Peginterferon alfa-2b | Deferiprone | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
268,
25,
1292
]
],
[
[
268,
24,
45
],
[
45,
24,
1292
]
],
[
[
268,
25,
72
],
[
72,
24,
1292
]
],
[
[
268,
24,
482
],
[
482,
25,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine"
],
... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Peginterferon alfa-2b may lead to a major life threatening interaction when taken with Eltrombopag a... |
DB01175 | DB01211 | 318 | 609 | [
"DDInter672",
"DDInter393"
] | Escitalopram | Clarithromycin | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
318,
25,
609
]
],
[
[
318,
6,
10215
],
[
10215,
45,
609
]
],
[
[
318,
18,
6351
],
[
6351,
57,
609
]
],
[
[
318,
21,
28879
],
[
28879,
... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Escitalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
... | Escitalopram (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clarithromycin (Compound)
Escitalopram (Compound) downregulates COTL1 (Gene) and COTL1 (Gene) is downregulated by Clarithromycin (Compound)
Escitalopram (Compound) causes Gingival bleeding (Side Effect) and Gingival bleeding (Side Effect) is ca... |
DB14409 | DB14724 | 1,129 | 48 | [
"DDInter867",
"DDInter634"
] | Human adenovirus e serotype 4 strain cl-68578 antigen | Emapalumab | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Major | 2 | [
[
[
1129,
25,
48
]
],
[
[
1129,
63,
713
],
[
713,
24,
48
]
],
[
[
1129,
63,
713
],
[
713,
24,
1456
],
[
1456,
24,
48
]
],
[
[
1129,
... | [
[
[
"Human adenovirus e serotype 4 strain cl-68578 antigen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Emapalumab"
]
],
[
[
"Human adenovirus e serotype 4 strain cl-68578 antigen",
"{u} may cause a moderate interaction that could exace... | Human adenovirus e serotype 4 strain cl-68578 antigen may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Human adenovirus e serotype 4 strain cl-68578 antigen m... |
DB00731 | DB09082 | 1,144 | 659 | [
"DDInter1269",
"DDInter1934"
] | Nateglinide | Vilanterol | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1144,
24,
659
]
],
[
[
1144,
24,
1220
],
[
1220,
23,
659
]
],
[
[
1144,
63,
1573
],
[
1573,
23,
659
]
],
[
[
1144,
63,
88
],
[
88,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and ... |
DB00970 | DB01042 | 0 | 1,307 | [
"DDInter466",
"DDInter1144"
] | Dactinomycin | Melphalan | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Moderate | 1 | [
[
[
0,
24,
1307
]
],
[
[
0,
5,
11618
],
[
11618,
44,
1307
]
],
[
[
0,
18,
2969
],
[
2969,
46,
1307
]
],
[
[
0,
21,
28714
],
[
28714,
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
]
],
[
[
"Dactinomycin",
"{u} (Compound) treats {v} (Disease)",
"peripheral nervous system neoplasm"
],
[
"peripheral nervous s... | Dactinomycin (Compound) treats peripheral nervous system neoplasm (Disease) and peripheral nervous system neoplasm (Disease) is treated by Melphalan (Compound)
Dactinomycin (Compound) downregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Melphalan (Compound)
Dactinomycin (Compound) causes Asthenia (Side Effec... |
DB00532 | DB06273 | 208 | 980 | [
"DDInter1152",
"DDInter1824"
] | Mephenytoin | Tocilizumab | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
208,
24,
980
]
],
[
[
208,
24,
850
],
[
850,
63,
980
]
],
[
[
208,
63,
1031
],
[
1031,
24,
980
]
],
[
[
208,
24,
1487
],
[
1487,
... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00981 | DB01019 | 1,528 | 427 | [
"DDInter1462",
"DDInter199"
] | Physostigmine | Bethanechol | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For exampl... | Moderate | 1 | [
[
[
1528,
24,
427
]
],
[
[
1528,
21,
28722
],
[
28722,
60,
427
]
],
[
[
1528,
63,
1442
],
[
1442,
24,
427
]
],
[
[
1528,
24,
1116
],
[
111... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bethanechol"
]
],
[
[
"Physostigmine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is cau... | Physostigmine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Bethanechol (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Beth... |
DB01403 | DB11837 | 9 | 1,297 | [
"DDInter1175",
"DDInter1351"
] | Methotrimeprazine | Osilodrostat | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
9,
24,
1297
]
],
[
[
9,
62,
112
],
[
112,
23,
1297
]
],
[
[
9,
63,
401
],
[
401,
24,
1297
]
],
[
[
9,
24,
657
],
[
657,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole... | Methotrimeprazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Pro... |
DB00834 | DB01284 | 932 | 1,042 | [
"DDInter1215",
"DDInter1782"
] | Mifepristone | Tetracosactide | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Major | 2 | [
[
[
932,
25,
1042
]
],
[
[
932,
24,
455
],
[
455,
23,
1042
]
],
[
[
932,
25,
688
],
[
688,
23,
1042
]
],
[
[
932,
24,
659
],
[
659,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tetracosactide"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
"Sa... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Mifepristone may lead to a major life threatening interaction when taken with Salbutamol and Salbutamol may ... |
DB00405 | DB01200 | 128 | 469 | [
"DDInter517",
"DDInter243"
] | Dexbrompheniramine | Bromocriptine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
128,
24,
469
]
],
[
[
128,
24,
401
],
[
401,
24,
469
]
],
[
[
128,
63,
701
],
[
701,
24,
469
]
],
[
[
128,
24,
407
],
[
407,
63,... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prometha... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Bromocriptine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00295 | DB00899 | 475 | 411 | [
"DDInter1244",
"DDInter1579"
] | Morphine | Remifentanil | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Moderate | 1 | [
[
[
475,
24,
411
]
],
[
[
475,
24,
1322
],
[
1322,
40,
411
]
],
[
[
475,
25,
704
],
[
704,
1,
411
]
],
[
[
475,
24,
1454
],
[
1454,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alfentanil"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Alfentanil and Alfentanil (Compound) resembles Remifentanil (Compound)
Morphine may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Remifentanil (Compound)
Morphine may cause ... |
DB00945 | DB01082 | 1,479 | 1,448 | [
"DDInter20",
"DDInter1713"
] | Acetylsalicylic acid | Streptomycin | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
1479,
24,
1448
]
],
[
[
1479,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
1479,
21,
28981
],
[
28981,
60,
1448
]
],
[
[
1479,
63,
1027
],
[
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is b... | Acetylsalicylic acid (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Acetylsalicylic acid (Compound) causes Renal impairment (Side Effect) and Renal impairment (Side Effect) is caused by Streptomycin (Compound)
Acetylsalicylic acid may cause a moderate interaction that could exace... |
DB00222 | DB00280 | 245 | 494 | [
"DDInter825",
"DDInter575"
] | Glimepiride | Disopyramide | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Moderate | 1 | [
[
[
245,
24,
494
]
],
[
[
245,
24,
675
],
[
675,
40,
494
]
],
[
[
245,
21,
28658
],
[
28658,
60,
494
]
],
[
[
245,
24,
752
],
[
752,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Disopyramide (Compound)
Glimepiride (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Disopyramide (Compound)
Glimepiride may cause a ... |
DB00641 | DB00682 | 467 | 126 | [
"DDInter1675",
"DDInter1951"
] | Simvastatin | Warfarin | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Minor | 0 | [
[
[
467,
23,
126
]
],
[
[
467,
24,
1335
],
[
1335,
40,
126
]
],
[
[
467,
6,
3486
],
[
3486,
45,
126
]
],
[
[
467,
63,
168
],
[
168,
... | [
[
[
"Simvastatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
],
[
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Warfarin (Compound)
Simvastatin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Warfarin (Compound)
Simvastatin may cause a moderate interaction that could exacer... |
DB00673 | DB08820 | 723 | 1,478 | [
"DDInter112",
"DDInter997"
] | Aprepitant | Ivacaftor | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Major | 2 | [
[
[
723,
25,
1478
]
],
[
[
723,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
723,
54,
19146
],
[
19146,
15,
1478
]
],
[
[
723,
21,
29221
],
[
2922... | [
[
[
"Aprepitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ivacafto... | Aprepitant (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Aprepitant (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Ivacaftor (Compound)
Aprepitant (Compound) causes Infestation (Side Eff... |
DB01035 | DB09134 | 1,401 | 1,552 | [
"DDInter1524",
"DDInter966"
] | Procainamide | Ioversol | A derivative of procaine with less CNS action. | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
1401,
24,
1552
]
],
[
[
1401,
63,
1645
],
[
1645,
25,
1552
]
],
[
[
1401,
64,
485
],
[
485,
25,
1552
]
],
[
[
1401,
63,
1645
],
[
1645... | [
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Procainamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
[
... | Procainamide may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may lead to a major life threatening interaction when taken with Ioversol
Procainamide may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may lead to a major lif... |
DB01024 | DB01165 | 1,096 | 1,539 | [
"DDInter1252",
"DDInter1325"
] | Mycophenolic acid | Ofloxacin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
1096,
24,
1539
]
],
[
[
1096,
63,
1467
],
[
1467,
1,
1539
]
],
[
[
1096,
24,
945
],
[
945,
40,
1539
]
],
[
[
1096,
24,
246
],
[
246,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin... |
DB12130 | DB12301 | 1,017 | 907 | [
"DDInter1094",
"DDInter585"
] | Lorlatinib | Doravirine | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Major | 2 | [
[
[
1017,
25,
907
]
],
[
[
1017,
63,
1478
],
[
1478,
23,
907
]
],
[
[
1017,
24,
159
],
[
159,
62,
907
]
],
[
[
1017,
25,
283
],
[
283,
... | [
[
[
"Lorlatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doravirine"
]
],
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",... | Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotre... |
DB04844 | DB11978 | 843 | 124 | [
"DDInter1778",
"DDInter822"
] | Tetrabenazine | Glasdegib | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
843,
24,
124
]
],
[
[
843,
62,
112
],
[
112,
23,
124
]
],
[
[
843,
63,
475
],
[
475,
24,
124
]
],
[
[
843,
24,
1670
],
[
1670,
2... | [
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Tetrabenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Tetrabenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and M... |
DB00224 | DB00620 | 215 | 175 | [
"DDInter917",
"DDInter1855"
] | Indinavir | Triamcinolone | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Major | 2 | [
[
[
215,
25,
175
]
],
[
[
215,
24,
1573
],
[
1573,
1,
175
]
],
[
[
215,
25,
617
],
[
617,
40,
175
]
],
[
[
215,
25,
1486
],
[
1486,
... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
"Prednison... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Indinavir may lead to a major life threatening interaction when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (Compound)
Indinavir m... |
DB01263 | DB08868 | 859 | 1,011 | [
"DDInter1494",
"DDInter737"
] | Posaconazole | Fingolimod | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
859,
25,
1011
]
],
[
[
859,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
859,
21,
29097
],
[
29097,
60,
1011
]
],
[
[
859,
25,
578
],
[
578,
... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Posaconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fin... | Posaconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Posaconazole (Compound) causes Eye pain (Side Effect) and Eye pain (Side Effect) is caused by Fingolimod (Compound)
Posaconazole may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may ... |
DB12130 | DB15822 | 1,017 | 69 | [
"DDInter1094",
"DDInter1504"
] | Lorlatinib | Pralsetinib | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
1017,
24,
69
]
],
[
[
1017,
25,
283
],
[
283,
24,
69
]
],
[
[
1017,
63,
1446
],
[
1446,
24,
69
]
],
[
[
1017,
64,
124
],
[
124,
... | [
[
[
"Lorlatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Lorlatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratini... | Lorlatinib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide and Lanreotide may cause... |
DB08881 | DB12301 | 868 | 907 | [
"DDInter1925",
"DDInter585"
] | Vemurafenib | Doravirine | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Moderate | 1 | [
[
[
868,
24,
907
]
],
[
[
868,
63,
1478
],
[
1478,
23,
907
]
],
[
[
868,
24,
159
],
[
159,
62,
907
]
],
[
[
868,
64,
1213
],
[
1213,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doravirine"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB00314 | DB01285 | 894 | 708 | [
"DDInter288",
"DDInter445"
] | Capreomycin | Corticotropin | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
894,
24,
708
]
],
[
[
894,
24,
123
],
[
123,
24,
708
]
],
[
[
894,
24,
1662
],
[
1662,
63,
708
]
],
[
[
894,
24,
123
],
[
123,
6... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
],
... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid ... |
DB00029 | DB05578 | 25 | 330 | [
"DDInter99",
"DDInter1566"
] | Anistreplase | Ramucirumab | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Major | 2 | [
[
[
25,
25,
330
]
],
[
[
25,
24,
41
],
[
41,
63,
330
]
],
[
[
25,
24,
901
],
[
901,
24,
330
]
],
[
[
25,
24,
1317
],
[
1317,
25,
... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ramucirumab"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
"... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Milnac... |
DB00679 | DB00836 | 684 | 543 | [
"DDInter1796",
"DDInter1088"
] | Thioridazine | Loperamide | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
684,
24,
543
]
],
[
[
684,
24,
649
],
[
649,
1,
543
]
],
[
[
684,
24,
262
],
[
262,
24,
543
]
],
[
[
684,
64,
888
],
[
888,
24,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
... | Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Loperamide (Compound)
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that cou... |
DB01191 | DB09075 | 1,039 | 498 | [
"DDInter518",
"DDInter621"
] | Dexfenfluramine | Edoxaban | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
1039,
24,
498
]
],
[
[
1039,
25,
41
],
[
41,
24,
498
]
],
[
[
1039,
64,
109
],
[
109,
24,
498
]
],
[
[
1039,
24,
958
],
[
958,
2... | [
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Dexfenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
],
[
... | Dexfenfluramine may lead to a major life threatening interaction when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Dexfenfluramine may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine may cau... |
DB00106 | DB00938 | 618 | 455 | [
"DDInter4",
"DDInter1635"
] | Abarelix | Salmeterol | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
618,
24,
455
]
],
[
[
618,
24,
688
],
[
688,
63,
455
]
],
[
[
618,
25,
1568
],
[
1568,
63,
455
]
],
[
[
618,
24,
1262
],
[
1262,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Abarelix may lead to a major life threatening interaction when taken with Pimozide and Pimozide may cause a modera... |
DB00388 | DB06203 | 1,636 | 1,002 | [
"DDInter1453",
"DDInter51"
] | Phenylephrine | Alogliptin | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
1636,
24,
1002
]
],
[
[
1636,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
1636,
21,
29232
],
[
29232,
60,
1002
]
],
[
[
1636,
24,
1529
],
[
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Phenylephrine (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Alogliptin (Compound)
Phenylephrine may cause a moderate i... |
DB00747 | DB01403 | 1,442 | 9 | [
"DDInter1647",
"DDInter1175"
] | Scopolamine | Methotrimeprazine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1442,
24,
9
]
],
[
[
1442,
24,
1178
],
[
1178,
40,
9
]
],
[
[
1442,
63,
1164
],
[
1164,
1,
9
]
],
[
[
1442,
63,
684
],
[
684,
40... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles... |
DB00081 | DB00328 | 273 | 831 | [
"DDInter1838",
"DDInter921"
] | Tositumomab | Indomethacin | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Major | 2 | [
[
[
273,
25,
831
]
],
[
[
273,
24,
1263
],
[
1263,
1,
831
]
],
[
[
273,
25,
24
],
[
24,
1,
831
]
],
[
[
273,
25,
848
],
[
848,
63,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Indomethacin"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
],
[
"Bromfen... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac (Compound) resembles Indomethacin (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Tolmetin and Tolmetin (Compound) resembles Indomethacin (Compound)
Tositumomab may... |
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