drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01124 | DB01404 | 1,411 | 757 | [
"DDInter1828",
"DDInter820"
] | Tolbutamide | Ginseng | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
1411,
24,
757
]
],
[
[
1411,
1,
245
],
[
245,
24,
757
]
],
[
[
1411,
24,
170
],
[
170,
24,
757
]
],
[
[
1411,
24,
1344
],
[
1344,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Tolbutamide",
"{u} (Compound) resembles {v} (Compound)",
"Glimepiride"
],
[
"Glimepiride",
"{u} may cause a modera... | Tolbutamide (Compound) resembles Glimepiride (Compound) and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that co... |
DB00816 | DB01367 | 1,674 | 1,163 | [
"DDInter1346",
"DDInter1572"
] | Orciprenaline | Rasagiline | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
1674,
24,
1163
]
],
[
[
1674,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
1674,
63,
590
],
[
590,
24,
1163
]
],
[
[
1674,
24,
1520
],
[
15... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Orciprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is ... | Orciprenaline (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB01394 | DB08871 | 1,554 | 36 | [
"DDInter431",
"DDInter666"
] | Colchicine | Eribulin | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1554,
24,
36
]
],
[
[
1554,
6,
8785
],
[
8785,
45,
36
]
],
[
[
1554,
7,
16974
],
[
16974,
45,
36
]
],
[
[
1554,
63,
1488
],
[
1488,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Colchicine",
"{u} (Compound) binds {v} (Gene)",
"TUBB"
],
[
"TUBB",
"{u} (Gene) is bound by {v} (Compound)",
... | Colchicine (Compound) binds TUBB (Gene) and TUBB (Gene) is bound by Eribulin (Compound)
Colchicine (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moder... |
DB00476 | DB09330 | 109 | 985 | [
"DDInter608",
"DDInter1352"
] | Duloxetine | Osimertinib | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
109,
24,
985
]
],
[
[
109,
24,
480
],
[
480,
24,
985
]
],
[
[
109,
63,
1684
],
[
1684,
24,
985
]
],
[
[
109,
24,
283
],
[
283,
6... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffein... |
DB00682 | DB09046 | 126 | 1,094 | [
"DDInter1951",
"DDInter1201"
] | Warfarin | Metreleptin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
126,
24,
1094
]
],
[
[
126,
62,
168
],
[
168,
23,
1094
]
],
[
[
126,
24,
578
],
[
578,
24,
1094
]
],
[
[
126,
25,
1213
],
[
1213,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
"... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Metreleptin
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor ma... |
DB00030 | DB01124 | 1,685 | 1,411 | [
"DDInter934",
"DDInter1828"
] | Insulin human | Tolbutamide | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1685,
24,
1411
]
],
[
[
1685,
24,
959
],
[
959,
40,
1411
]
],
[
[
1685,
23,
333
],
[
333,
23,
1411
]
],
[
[
1685,
24,
1161
],
[
1161,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Insulin human may cause a minor interaction that can limit clinical effects when taken with Lipoic acid and Lipoic acid may cause a minor interaction that can... |
DB01246 | DB01409 | 820 | 1,415 | [
"DDInter45",
"DDInter1815"
] | Alimemazine | Tiotropium | A phenothiazine derivative that is used as an antipruritic. | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
820,
24,
1415
]
],
[
[
820,
6,
8374
],
[
8374,
45,
1415
]
],
[
[
820,
21,
28680
],
[
28680,
60,
1415
]
],
[
[
820,
1,
146
],
[
146,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Alimemazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Alimemazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tiotropium (Compound)
Alimemazine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Tiotropium (Compound)
Alimemazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that could ... |
DB00831 | DB11837 | 1,178 | 1,297 | [
"DDInter1866",
"DDInter1351"
] | Trifluoperazine | Osilodrostat | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1178,
24,
1297
]
],
[
[
1178,
23,
112
],
[
112,
23,
1297
]
],
[
[
1178,
24,
222
],
[
222,
23,
1297
]
],
[
[
1178,
1,
623
],
[
623,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutra... |
DB00480 | DB01076 | 1,668 | 700 | [
"DDInter1035",
"DDInter133"
] | Lenalidomide | Atorvastatin | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Major | 2 | [
[
[
1668,
25,
700
]
],
[
[
1668,
25,
788
],
[
788,
1,
700
]
],
[
[
1668,
6,
4973
],
[
4973,
45,
700
]
],
[
[
1668,
23,
126
],
[
126,
... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Atorvastatin"
]
],
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pitavastatin"
],
[
"Pitavastatin",
... | Lenalidomide may lead to a major life threatening interaction when taken with Pitavastatin and Pitavastatin (Compound) resembles Atorvastatin (Compound)
Lenalidomide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atorvastatin (Compound)
Lenalidomide may cause a minor interaction that can limit clinical effe... |
DB12001 | DB14444 | 564 | 151 | [
"DDInter7",
"DDInter924"
] | Abemaciclib | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
564,
24,
151
]
],
[
[
564,
63,
66
],
[
66,
24,
151
]
],
[
[
564,
64,
375
],
[
375,
24,
151
]
],
[
[
564,
25,
676
],
[
676,
63,
... | [
[
[
"Abemaciclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Abemaciclib",
"{u} may cause a moderate interaction that could... | Abemaciclib may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Abemaciclib may lead to a major life... |
DB00983 | DB01105 | 480 | 222 | [
"DDInter776",
"DDInter1665"
] | Formoterol | Sibutramine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
480,
24,
222
]
],
[
[
480,
18,
2114
],
[
2114,
57,
222
]
],
[
[
480,
21,
28698
],
[
28698,
60,
222
]
],
[
[
480,
63,
839
],
[
839,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Formoterol",
"{u} (Compound) downregulates {v} (Gene)",
"MIF"
],
[
"MIF",
"{u} (Gene) is downregulated by {v} (... | Formoterol (Compound) downregulates MIF (Gene) and MIF (Gene) is downregulated by Sibutramine (Compound)
Formoterol (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Grepaflox... |
DB00209 | DB00405 | 352 | 128 | [
"DDInter1886",
"DDInter517"
] | Trospium | Dexbrompheniramine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
352,
24,
128
]
],
[
[
352,
24,
662
],
[
662,
63,
128
]
],
[
[
352,
63,
677
],
[
677,
24,
128
]
],
[
[
352,
24,
1386
],
[
1386,
2... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Botulinum t... |
DB00636 | DB00912 | 429 | 473 | [
"DDInter408",
"DDInter1581"
] | Clofibrate | Repaglinide | A fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p986) | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
429,
24,
473
]
],
[
[
429,
6,
8374
],
[
8374,
45,
473
]
],
[
[
429,
1,
535
],
[
535,
63,
473
]
],
[
[
429,
24,
629
],
[
629,
24,... | [
[
[
"Clofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Clofibrate",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Clofibrate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound)
Clofibrate (Compound) resembles Fenofibrate (Compound) and Fenofibrate may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Clofibrate may cause a moderate interaction that could exacerb... |
DB09570 | DB10583 | 1,480 | 949 | [
"DDInter1002",
"DDInter415"
] | Ixazomib | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
1480,
24,
949
]
],
[
[
1480,
63,
589
],
[
589,
24,
949
]
],
[
[
1480,
64,
1377
],
[
1377,
24,
949
]
],
[
[
1480,
25,
1259
],
[
1259,
... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Ixazomib may lead to a major life threatening interaction when tak... |
DB01255 | DB04868 | 633 | 478 | [
"DDInter1078",
"DDInter1293"
] | Lisdexamfetamine | Nilotinib | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
633,
25,
478
]
],
[
[
633,
21,
28963
],
[
28963,
60,
478
]
],
[
[
633,
62,
112
],
[
112,
23,
478
]
],
[
[
633,
63,
1559
],
[
1559,
... | [
[
[
"Lisdexamfetamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Lisdexamfetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Anxiety"
],
[
"Anxiety",
"{u} (Side Effect) is caused by {v... | Lisdexamfetamine (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken wit... |
DB00357 | DB11978 | 1,051 | 124 | [
"DDInter71",
"DDInter822"
] | Aminoglutethimide | Glasdegib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1051,
24,
124
]
],
[
[
1051,
24,
1135
],
[
1135,
23,
124
]
],
[
[
1051,
24,
466
],
[
466,
62,
124
]
],
[
[
1051,
24,
79
],
[
79,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide... |
DB00048 | DB00569 | 1,595 | 553 | [
"DDInter435",
"DDInter775"
] | Collagenase clostridium histolyticum | Fondaparinux | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Moderate | 1 | [
[
[
1595,
24,
553
]
],
[
[
1595,
24,
477
],
[
477,
64,
553
]
],
[
[
1595,
24,
1167
],
[
1167,
25,
553
]
],
[
[
1595,
63,
1271
],
[
1271,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fondaparinux"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases wh... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may lead to a major life threatening interaction when taken with Fondaparinux
Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate disease... |
DB01064 | DB01410 | 1,148 | 423 | [
"DDInter987",
"DDInter375"
] | Isoprenaline | Ciclesonide | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Minor | 0 | [
[
[
1148,
23,
423
]
],
[
[
1148,
62,
1573
],
[
1573,
1,
423
]
],
[
[
1148,
62,
1351
],
[
1351,
40,
423
]
],
[
[
1148,
23,
617
],
[
617,
... | [
[
[
"Isoprenaline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ciclesonide"
]
],
[
[
"Isoprenaline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
],
[
... | Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Isoprenaline may cause a minor interaction that can limit clinical effects when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Compou... |
DB00863 | DB01199 | 1,194 | 1,217 | [
"DDInter1568",
"DDInter1890"
] | Ranitidine | Tubocurarine | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera _Chondrodend... | Minor | 0 | [
[
[
1194,
23,
1217
]
],
[
[
1194,
23,
545
],
[
545,
1,
1217
]
],
[
[
1194,
6,
10715
],
[
10715,
45,
1217
]
],
[
[
1194,
63,
1031
],
[
1031... | [
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tubocurarine"
]
],
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metocurine"
],
[
... | Ranitidine may cause a minor interaction that can limit clinical effects when taken with Metocurine and Metocurine (Compound) resembles Tubocurarine (Compound)
Ranitidine (Compound) binds SLC22A1 (Gene) and SLC22A1 (Gene) is bound by Tubocurarine (Compound)
Ranitidine may cause a moderate interaction that could exacerb... |
DB00099 | DB01157 | 440 | 304 | [
"DDInter735",
"DDInter1875"
] | Filgrastim | Trimetrexate | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Moderate | 1 | [
[
[
440,
24,
304
]
],
[
[
440,
63,
599
],
[
599,
24,
304
]
],
[
[
440,
24,
869
],
[
869,
24,
304
]
],
[
[
440,
24,
384
],
[
384,
63,... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimetrexate"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
],
[... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Trimetrexate
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Top... |
DB10795 | DB11817 | 221 | 1,259 | [
"DDInter1486",
"DDInter165"
] | Poliovirus type 1 antigen (formaldehyde inactivated) | Baricitinib | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
221,
24,
1259
]
],
[
[
221,
63,
384
],
[
384,
25,
1259
]
],
[
[
221,
24,
1619
],
[
1619,
64,
1259
]
],
[
[
221,
24,
351
],
[
351,
... | [
[
[
"Poliovirus type 1 antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Poliovirus type 1 antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction th... | Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may lead to a major life threatening interaction when taken with Baricitinib
Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interactio... |
DB00631 | DB01211 | 372 | 609 | [
"DDInter405",
"DDInter393"
] | Clofarabine | Clarithromycin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
372,
24,
609
]
],
[
[
372,
63,
1570
],
[
1570,
24,
609
]
],
[
[
372,
18,
7039
],
[
7039,
57,
609
]
],
[
[
372,
7,
2096
],
[
2096,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Clofarabine (Compound) downregulates TLE1 (Gene) and TLE1 (Gene) is downregulated by Clarithromycin (Co... |
DB00363 | DB06282 | 695 | 516 | [
"DDInter419",
"DDInter1053"
] | Clozapine | Levocetirizine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
695,
24,
516
]
],
[
[
695,
63,
701
],
[
701,
24,
516
]
],
[
[
695,
24,
1614
],
[
1614,
24,
516
]
],
[
[
695,
40,
1178
],
[
1178,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilo... |
DB00468 | DB01155 | 1,424 | 872 | [
"DDInter1557",
"DDInter813"
] | Quinine | Gemifloxacin | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
1424,
24,
872
]
],
[
[
1424,
24,
739
],
[
739,
1,
872
]
],
[
[
1424,
25,
945
],
[
945,
40,
872
]
],
[
[
1424,
64,
1176
],
[
1176,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Quinine may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Gemifloxacin (Compound)
Quinine m... |
DB00836 | DB06288 | 543 | 607 | [
"DDInter1088",
"DDInter77"
] | Loperamide | Amisulpride | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Moderate | 1 | [
[
[
543,
24,
607
]
],
[
[
543,
21,
29232
],
[
29232,
60,
607
]
],
[
[
543,
24,
112
],
[
112,
23,
607
]
],
[
[
543,
24,
144
],
[
144,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amisulpride"
]
],
[
[
"Loperamide",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is cau... | Loperamide (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Amisulpride (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Am... |
DB00063 | DB09030 | 366 | 840 | [
"DDInter659",
"DDInter1945"
] | Eptifibatide | Vorapaxar | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Vorapaxar is a tricyclic himbacine-derived selective inhibitor of protease activated receptor (PAR-1) indicated for reducing the incidence of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD). By inhibiting PAR-1, a thrombin receptor expr... | Major | 2 | [
[
[
366,
25,
840
]
],
[
[
366,
23,
944
],
[
944,
62,
840
]
],
[
[
366,
24,
765
],
[
765,
24,
840
]
],
[
[
366,
24,
1496
],
[
1496,
6... | [
[
[
"Eptifibatide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
]
],
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile"... | Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Vorapaxar
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Hemin and Hemin may caus... |
DB00454 | DB00470 | 1,349 | 530 | [
"DDInter1150",
"DDInter601"
] | Meperidine | Dronabinol | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
1349,
24,
530
]
],
[
[
1349,
24,
1614
],
[
1614,
40,
530
]
],
[
[
1349,
6,
10215
],
[
10215,
45,
530
]
],
[
[
1349,
21,
29118
],
[
291... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
[
... | Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Meperidine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Dronabinol (Compound)
Meperidine (Compound) causes Tachycardia (Side Effect) and Tachycard... |
DB00570 | DB01073 | 147 | 1,488 | [
"DDInter1936",
"DDInter745"
] | Vinblastine | Fludarabine | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Moderate | 1 | [
[
[
147,
24,
1488
]
],
[
[
147,
24,
372
],
[
372,
1,
1488
]
],
[
[
147,
5,
11555
],
[
11555,
44,
1488
]
],
[
[
147,
18,
2104
],
[
2104,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Vinblastine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Fludarabine (Compound)
Vinblastine (Compound) down... |
DB01097 | DB15044 | 1,377 | 631 | [
"DDInter1033",
"DDInter1738"
] | Leflunomide | Tafasitamab | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytoto... | Major | 2 | [
[
[
1377,
25,
631
]
],
[
[
1377,
25,
4
],
[
4,
24,
631
]
],
[
[
1377,
64,
869
],
[
869,
24,
631
]
],
[
[
1377,
63,
597
],
[
597,
24,... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tafasitamab"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
],
[
"Omaceta... | Leflunomide may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Tafasitamab
Leflunomide may lead to a major life threatening interaction when taken with Topotecan and Topo... |
DB01073 | DB06674 | 1,488 | 908 | [
"DDInter745",
"DDInter837"
] | Fludarabine | Golimumab | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1488,
25,
908
]
],
[
[
1488,
63,
1461
],
[
1461,
23,
908
]
],
[
[
1488,
63,
268
],
[
268,
24,
908
]
],
[
[
1488,
24,
505
],
[
505,
... | [
[
[
"Fludarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Golimumab
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b an... |
DB05273 | DB09570 | 507 | 1,480 | [
"DDInter1638",
"DDInter1002"
] | Samarium (153Sm) lexidronam | Ixazomib | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Major | 2 | [
[
[
507,
25,
1480
]
],
[
[
507,
64,
268
],
[
268,
24,
1480
]
],
[
[
507,
63,
248
],
[
248,
24,
1480
]
],
[
[
507,
25,
310
],
[
310,
... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixazomib"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon alfa-2b"
... | Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Samarium (153Sm) lexidronam may cause a moderate interaction that could exacerbate disease... |
DB00344 | DB01105 | 1,302 | 222 | [
"DDInter1543",
"DDInter1665"
] | Protriptyline | Sibutramine | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Major | 2 | [
[
[
1302,
25,
222
]
],
[
[
1302,
6,
6112
],
[
6112,
45,
222
]
],
[
[
1302,
18,
7359
],
[
7359,
57,
222
]
],
[
[
1302,
21,
28852
],
[
28852... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
]
],
[
[
"Protriptyline",
"{u} (Compound) binds {v} (Gene)",
"SLC6A4"
],
[
"SLC6A4",
"{u} (Gene) is bound by {v} (Compound)",
"... | Protriptyline (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Sibutramine (Compound)
Protriptyline (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Sibutramine (Compound)
Protriptyline (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Sibutrami... |
DB00396 | DB12130 | 989 | 1,017 | [
"DDInter1529",
"DDInter1094"
] | Progesterone | Lorlatinib | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is used in var... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
989,
24,
1017
]
],
[
[
989,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
989,
24,
590
],
[
590,
24,
1017
]
],
[
[
989,
1,
984
],
[
984,
... | [
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and A... |
DB01254 | DB04908 | 1,213 | 1,671 | [
"DDInter484",
"DDInter741"
] | Dasatinib | Flibanserin | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
1213,
24,
1671
]
],
[
[
1213,
23,
1135
],
[
1135,
62,
1671
]
],
[
[
1213,
24,
98
],
[
98,
63,
1671
]
],
[
[
1213,
63,
303
],
[
303,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Flibanserin
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may ca... |
DB01118 | DB09049 | 33 | 1,135 | [
"DDInter76",
"DDInter1261"
] | Amiodarone | Naloxegol | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Minor | 0 | [
[
[
33,
23,
1135
]
],
[
[
33,
25,
971
],
[
971,
62,
1135
]
],
[
[
33,
64,
1424
],
[
1424,
23,
1135
]
],
[
[
33,
25,
1069
],
[
1069,
... | [
[
[
"Amiodarone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
]
],
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
],
[
"Gilteritini... | Amiodarone may lead to a major life threatening interaction when taken with Gilteritinib and Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Amiodarone may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a minor interaction ... |
DB00204 | DB00549 | 228 | 522 | [
"DDInter580",
"DDInter1955"
] | Dofetilide | Zafirlukast | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
228,
24,
522
]
],
[
[
228,
6,
8374
],
[
8374,
45,
522
]
],
[
[
228,
21,
28698
],
[
28698,
60,
522
]
],
[
[
228,
25,
1487
],
[
1487,
... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Dofetilide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Dofetilide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zafirlukast (Compound)
Dofetilide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Zafirlukast (Compound)
Dofetilide may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychlo... |
DB00615 | DB12001 | 690 | 564 | [
"DDInter1589",
"DDInter7"
] | Rifabutin | Abemaciclib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
690,
24,
564
]
],
[
[
690,
25,
868
],
[
868,
24,
564
]
],
[
[
690,
24,
392
],
[
392,
24,
564
]
],
[
[
690,
63,
600
],
[
600,
24,... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
],
[
"Vemurafeni... | Rifabutin may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a... |
DB06210 | DB06290 | 72 | 1,449 | [
"DDInter631",
"DDInter1673"
] | Eltrombopag | Simeprevir | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Moderate | 1 | [
[
[
72,
24,
1449
]
],
[
[
72,
6,
7950
],
[
7950,
45,
1449
]
],
[
[
72,
54,
19186
],
[
19186,
15,
1449
]
],
[
[
72,
24,
119
],
[
119,
... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simeprevir"
]
],
[
[
"Eltrombopag",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Eltrombopag (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Simeprevir (Compound)
Eltrombopag (Compound) is included by Organic Anion Transporting Polypeptide 1B1 Inhibitors (Pharmacologic Class) and Organic Anion Transporting Polypeptide 1B1 Inhibitors (Pharmacologic Class) includes Simeprevir (Compound)
... |
DB00515 | DB01097 | 589 | 1,377 | [
"DDInter387",
"DDInter1033"
] | Cisplatin | Leflunomide | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
589,
25,
1377
]
],
[
[
589,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
589,
21,
29231
],
[
29231,
60,
1377
]
],
[
[
589,
63,
1461
],
[
1461,... | [
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Cisplatin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Leflunom... | Cisplatin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Cisplatin (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Leflunomide (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitami... |
DB01406 | DB13928 | 984 | 1,385 | [
"DDInter472",
"DDInter1660"
] | Danazol | Semaglutide | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
984,
24,
1385
]
],
[
[
984,
24,
1476
],
[
1476,
24,
1385
]
],
[
[
984,
63,
1144
],
[
1144,
24,
1385
]
],
[
[
984,
40,
1573
],
[
1573,
... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
"... | Danazol may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinid... |
DB00014 | DB00582 | 521 | 1,622 | [
"DDInter839",
"DDInter1946"
] | Goserelin | Voriconazole | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
521,
24,
1622
]
],
[
[
521,
21,
28957
],
[
28957,
60,
1622
]
],
[
[
521,
23,
112
],
[
112,
62,
1622
]
],
[
[
521,
24,
473
],
[
473,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Arthralgia"
],
[
"Arthralgia",
"{u} (Side Effect) is ca... | Goserelin (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Voriconazole (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vor... |
DB06824 | DB13257 | 29 | 260 | [
"DDInter1864",
"DDInter727"
] | Triethylenetetramine | Ferrous sulfate anhydrous | Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved... | Iron deficiency anemia is a large public health concern worldwide, especially in young children, infants, and women of childbearing age. This type of anemia occurs when iron intake, iron stores, and iron loss do not adequately support the formation of erythrocytes, also known as red blood cells. Ferrous sulfate is a sy... | Moderate | 1 | [
[
[
29,
24,
260
]
],
[
[
29,
23,
1114
],
[
1114,
23,
260
]
],
[
[
29,
24,
460
],
[
460,
24,
260
]
],
[
[
29,
63,
1283
],
[
1283,
24,... | [
[
[
"Triethylenetetramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous sulfate anhydrous"
]
],
[
[
"Triethylenetetramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
... | Triethylenetetramine may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Ferrous sulfate anhydrous
Triethylenetetramine may cause a moderate interaction that could exacerbate diseases wh... |
DB00857 | DB01136 | 1,387 | 772 | [
"DDInter1768",
"DDInter305"
] | Terbinafine | Carvedilol | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
1387,
24,
772
]
],
[
[
1387,
24,
371
],
[
371,
1,
772
]
],
[
[
1387,
40,
1576
],
[
1576,
1,
772
]
],
[
[
1387,
6,
12523
],
[
12523,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
],
[... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) resembles Carvedilol (Compound)
Terbinafine (Compound) resembles Propranolol (Compound) and Propranolol (Compound) resembles Carvedilol (Compound)
Terbinafine (Compound) binds CYP2D6 (Gene)... |
DB01234 | DB01254 | 1,220 | 1,213 | [
"DDInter513",
"DDInter484"
] | Dexamethasone | Dasatinib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
1220,
25,
1213
]
],
[
[
1220,
5,
11555
],
[
11555,
44,
1213
]
],
[
[
1220,
6,
17404
],
[
17404,
45,
1213
]
],
[
[
1220,
18,
7580
],
[
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Dexamethasone",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is trea... | Dexamethasone (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dasatinib (Compound)
Dexamethasone (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Dasatinib (Compound)
Dexamethasone (Compound) downregulates TESK1 (Gene) and TESK1 (Gene) is bound by Dasatinib (Compo... |
DB00491 | DB01072 | 127 | 915 | [
"DDInter1217",
"DDInter129"
] | Miglitol | Atazanavir | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Moderate | 1 | [
[
[
127,
24,
915
]
],
[
[
127,
24,
1327
],
[
1327,
1,
915
]
],
[
[
127,
21,
28810
],
[
28810,
60,
915
]
],
[
[
127,
63,
168
],
[
168,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atazanavir"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Atazanavir (Compound)
Miglitol (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Atazanavir (Compound)
Miglitol may cause a mod... |
DB11560 | DB11978 | 1,678 | 124 | [
"DDInter1038",
"DDInter822"
] | Lesinurad | Glasdegib | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1678,
24,
124
]
],
[
[
1678,
63,
112
],
[
112,
23,
124
]
],
[
[
1678,
24,
466
],
[
466,
62,
124
]
],
[
[
1678,
63,
79
],
[
79,
2... | [
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Dar... |
DB01072 | DB09054 | 915 | 384 | [
"DDInter129",
"DDInter905"
] | Atazanavir | Idelalisib | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
915,
24,
384
]
],
[
[
915,
25,
1618
],
[
1618,
24,
384
]
],
[
[
915,
63,
891
],
[
891,
24,
384
]
],
[
[
915,
62,
1387
],
[
1387,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabozant... | Atazanavir may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone ma... |
DB09065 | DB11703 | 760 | 405 | [
"DDInter424",
"DDInter9"
] | Cobicistat | Acalabrutinib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
760,
25,
405
]
],
[
[
760,
64,
690
],
[
690,
24,
405
]
],
[
[
760,
63,
139
],
[
139,
24,
405
]
],
[
[
760,
62,
1101
],
[
1101,
2... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rifabutin"
],
[
"Rifabutin",
"{u} ... | Cobicistat may lead to a major life threatening interaction when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause... |
DB08871 | DB11110 | 36 | 603 | [
"DDInter666",
"DDInter1115"
] | Eribulin | Magnesium citrate | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
36,
24,
603
]
],
[
[
36,
64,
57
],
[
57,
24,
603
]
],
[
[
36,
63,
789
],
[
789,
24,
603
]
],
[
[
36,
24,
484
],
[
484,
63,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Eribulin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
"A... | Eribulin may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Foscarn... |
DB00195 | DB06703 | 726 | 619 | [
"DDInter198",
"DDInter793"
] | Betaxolol (ophthalmic) | Gadobutrol | Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment... | Gadobutrol is a second-generation extracellular non-ionic macrocyclic GBCA (gadolinium-based contrast agent) used in magnetic resonance imaging (MRI) in adults and children older than 2 years of age. Due to its physicochemical properties, gadobutrol is formulated at twice the gadolinium ion concentration compared to ot... | Moderate | 1 | [
[
[
726,
24,
619
]
],
[
[
726,
21,
28643
],
[
28643,
60,
619
]
],
[
[
726,
1,
819
],
[
819,
24,
619
]
],
[
[
726,
24,
1013
],
[
1013,
... | [
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadobutrol"
]
],
[
[
"Betaxolol",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Effect) is caused... | Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Gadobutrol
Betaxolol (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Gadobutrol (Compound)
Betaxolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction tha... |
DB01364 | DB08907 | 22 | 1,344 | [
"DDInter650",
"DDInter280"
] | Ephedrine | Canagliflozin | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
22,
24,
1344
]
],
[
[
22,
24,
549
],
[
549,
1,
1344
]
],
[
[
22,
21,
28680
],
[
28680,
60,
1344
]
],
[
[
22,
40,
1445
],
[
1445,
... | [
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Ephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Ephedrine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Ephedrine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Canagliflozin (Compound)
Ephedrine (Compound) resembles Pseudoephedri... |
DB01124 | DB13873 | 1,411 | 1,534 | [
"DDInter1828",
"DDInter719"
] | Tolbutamide | Fenofibric acid | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L128... | Moderate | 1 | [
[
[
1411,
24,
1534
]
],
[
[
1411,
63,
1685
],
[
1685,
24,
1534
]
],
[
[
1411,
1,
959
],
[
959,
24,
1534
]
],
[
[
1411,
24,
1254
],
[
1254,... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibric acid"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin human"
]... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Fenofibric acid
Tolbutamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interaction... |
DB01136 | DB12364 | 772 | 1,421 | [
"DDInter305",
"DDInter200"
] | Carvedilol | Betrixaban | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
772,
25,
1421
]
],
[
[
772,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
772,
25,
1456
],
[
1456,
24,
1421
]
],
[
[
772,
63,
714
],
[
714,
... | [
[
[
"Carvedilol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
"Lorlatinib... | Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Carvedilol may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may cause ... |
DB11703 | DB14575 | 405 | 733 | [
"DDInter9",
"DDInter674"
] | Acalabrutinib | Eslicarbazepine | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
405,
24,
733
]
],
[
[
405,
63,
1101
],
[
1101,
23,
733
]
],
[
[
405,
63,
222
],
[
222,
24,
733
]
],
[
[
405,
25,
351
],
[
351,
2... | [
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
... | Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine ... |
DB00352 | DB00520 | 482 | 1,358 | [
"DDInter1814",
"DDInter306"
] | Tioguanine | Caspofungin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Moderate | 1 | [
[
[
482,
24,
1358
]
],
[
[
482,
21,
28826
],
[
28826,
60,
1358
]
],
[
[
482,
24,
267
],
[
267,
63,
1358
]
],
[
[
482,
63,
912
],
[
912,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caspofungin"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Jaundice"
],
[
"Jaundice",
"{u} (Side Effect) is cause... | Tioguanine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Caspofungin (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Caspofun... |
DB00490 | DB11730 | 946 | 351 | [
"DDInter254",
"DDInter1588"
] | Buspirone | Ribociclib | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
946,
24,
351
]
],
[
[
946,
25,
222
],
[
222,
23,
351
]
],
[
[
946,
24,
1532
],
[
1532,
24,
351
]
],
[
[
946,
63,
1324
],
[
1324,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Buspirone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sibutramine"
],
[
"Sibutramine... | Buspirone may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a ... |
DB00425 | DB01205 | 558 | 1,404 | [
"DDInter1970",
"DDInter748"
] | Zolpidem | Flumazenil | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | Minor | 0 | [
[
[
558,
23,
1404
]
],
[
[
558,
6,
6506
],
[
6506,
45,
1404
]
],
[
[
558,
21,
29003
],
[
29003,
60,
1404
]
],
[
[
558,
24,
1264
],
[
1264,... | [
[
[
"Zolpidem",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Flumazenil"
]
],
[
[
"Zolpidem",
"{u} (Compound) binds {v} (Gene)",
"GABRG2"
],
[
"GABRG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Zolpidem (Compound) binds GABRG2 (Gene) and GABRG2 (Gene) is bound by Flumazenil (Compound)
Zolpidem (Compound) causes Aggression (Side Effect) and Aggression (Side Effect) is caused by Flumazenil (Compound)
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may... |
DB00250 | DB01020 | 10 | 1,107 | [
"DDInter475",
"DDInter990"
] | Dapsone | Isosorbide mononitrate | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Isosorbide mononitrate is an organic nitrate with vasodilating properties. It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.[L11698, L11743] Isosorbide mononitrate is an active metabolite of [isosorbide dinitrate]. Li... | Moderate | 1 | [
[
[
10,
24,
1107
]
],
[
[
10,
24,
426
],
[
426,
40,
1107
]
],
[
[
10,
6,
8374
],
[
8374,
45,
1107
]
],
[
[
10,
21,
28722
],
[
28722,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isosorbide mononitrate"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isosorbide dinitrate"... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Isosorbide dinitrate and Isosorbide dinitrate (Compound) resembles Isosorbide mononitrate (Compound)
Dapsone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isosorbide mononitrate (Compound)
Dapsone (Compound) causes Na... |
DB06081 | DB08875 | 1,046 | 1,618 | [
"DDInter286",
"DDInter262"
] | Caplacizumab | Cabozantinib | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1046,
25,
1618
]
],
[
[
1046,
24,
41
],
[
41,
63,
1618
]
],
[
[
1046,
25,
283
],
[
283,
63,
1618
]
],
[
[
1046,
63,
222
],
[
222,
... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Caplacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
... | Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Caplacizumab may lead to a major life threatening interaction when taken with Fedratinib and Fedra... |
DB00813 | DB12130 | 704 | 1,017 | [
"DDInter722",
"DDInter1094"
] | Fentanyl | Lorlatinib | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
704,
25,
1017
]
],
[
[
704,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
704,
24,
976
],
[
976,
24,
1017
]
],
[
[
704,
40,
1454
],
[
1454,
... | [
[
[
"Fentanyl",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib... |
DB00092 | DB01177 | 58 | 77 | [
"DDInter40",
"DDInter904"
] | Alefacept | Idarubicin | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
58,
24,
77
]
],
[
[
58,
24,
496
],
[
496,
63,
77
]
],
[
[
58,
24,
1463
],
[
1463,
24,
77
]
],
[
[
58,
63,
1648
],
[
1648,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Lovas... |
DB00445 | DB01181 | 322 | 1,532 | [
"DDInter655",
"DDInter906"
] | Epirubicin | Ifosfamide | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
322,
24,
1532
]
],
[
[
322,
5,
11659
],
[
11659,
44,
1532
]
],
[
[
322,
18,
2976
],
[
2976,
57,
1532
]
],
[
[
322,
21,
28956
],
[
2895... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Epirubicin",
"{u} (Compound) treats {v} (Disease)",
"testicular cancer"
],
[
"testicular cancer",
"{u} (Disease)... | Epirubicin (Compound) treats testicular cancer (Disease) and testicular cancer (Disease) is treated by Ifosfamide (Compound)
Epirubicin (Compound) downregulates STUB1 (Gene) and STUB1 (Gene) is downregulated by Ifosfamide (Compound)
Epirubicin (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) ... |
DB00307 | DB01232 | 1,101 | 1,327 | [
"DDInter202",
"DDInter1640"
] | Bexarotene | Saquinavir | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
1101,
24,
1327
]
],
[
[
1101,
63,
798
],
[
798,
40,
1327
]
],
[
[
1101,
24,
915
],
[
915,
40,
1327
]
],
[
[
1101,
6,
8374
],
[
8374,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
... |
DB00398 | DB00950 | 79 | 1,413 | [
"DDInter1702",
"DDInter732"
] | Sorafenib | Fexofenadine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Moderate | 1 | [
[
[
79,
24,
1413
]
],
[
[
79,
25,
1568
],
[
1568,
1,
1413
]
],
[
[
79,
64,
576
],
[
576,
1,
1413
]
],
[
[
79,
24,
543
],
[
543,
1,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fexofenadine"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
],
[
"Pimozide",
... | Sorafenib may lead to a major life threatening interaction when taken with Pimozide and Pimozide (Compound) resembles Fexofenadine (Compound)
Sorafenib may lead to a major life threatening interaction when taken with Methadone and Methadone (Compound) resembles Fexofenadine (Compound)
Sorafenib may cause a moderate int... |
DB00633 | DB01075 | 614 | 1,376 | [
"DDInter520",
"DDInter569"
] | Dexmedetomidine | Diphenhydramine | An agonist of receptors, adrenergic alpha-2 that is used in veterinary medicine for its analgesic and sedative properties. It is the racemate of dexmedetomidine. | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
614,
24,
1376
]
],
[
[
614,
24,
649
],
[
649,
63,
1376
]
],
[
[
614,
63,
128
],
[
128,
24,
1376
]
],
[
[
614,
24,
832
],
[
832,
... | [
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Dexmedetomidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
... | Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Dexmedetomidine may cause a moderate interaction that could exacerbate diseases when taken with Dexbro... |
DB06176 | DB08875 | 1,342 | 1,618 | [
"DDInter1616",
"DDInter262"
] | Romidepsin | Cabozantinib | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1342,
25,
1618
]
],
[
[
1342,
62,
112
],
[
112,
23,
1618
]
],
[
[
1342,
24,
384
],
[
384,
63,
1618
]
],
[
[
1342,
63,
122
],
[
122,
... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Id... |
DB01155 | DB09020 | 872 | 28 | [
"DDInter813",
"DDInter212"
] | Gemifloxacin | Bisacodyl | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
872,
24,
28
]
],
[
[
872,
21,
28666
],
[
28666,
60,
28
]
],
[
[
872,
40,
739
],
[
739,
24,
28
]
],
[
[
872,
24,
823
],
[
823,
63... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Nervous system disorder"
],
[
"Nervous system disorder",
... | Gemifloxacin (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Gemifloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl
Gemifloxac... |
DB00331 | DB01144 | 1,645 | 1,326 | [
"DDInter1164",
"DDInter540"
] | Metformin | Diclofenamide | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Major | 2 | [
[
[
1645,
25,
1326
]
],
[
[
1645,
24,
504
],
[
504,
1,
1326
]
],
[
[
1645,
24,
359
],
[
359,
40,
1326
]
],
[
[
1645,
21,
29093
],
[
29093,... | [
[
[
"Metformin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenamide"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
],
[
"... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Diclofenamide (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resem... |
DB01254 | DB10429 | 1,213 | 200 | [
"DDInter484",
"DDInter282"
] | Dasatinib | Candida albicans | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1213,
24,
200
]
],
[
[
1213,
24,
1683
],
[
1683,
24,
200
]
],
[
[
1213,
25,
976
],
[
976,
24,
200
]
],
[
[
1213,
63,
1486
],
[
1486,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Dasatinib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00074 | DB00242 | 1,309 | 1,064 | [
"DDInter166",
"DDInter392"
] | Basiliximab | Cladribine | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Major | 2 | [
[
[
1309,
25,
1064
]
],
[
[
1309,
24,
1270
],
[
1270,
63,
1064
]
],
[
[
1309,
23,
1461
],
[
1461,
24,
1064
]
],
[
[
1309,
25,
779
],
[
779... | [
[
[
"Basiliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
]
],
[
[
"Basiliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
... | Basiliximab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Cladribine
Basiliximab may cause a minor interaction that can limi... |
DB00700 | DB00761 | 312 | 1,621 | [
"DDInter656",
"DDInter1497"
] | Eplerenone | Potassium chloride | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Major | 2 | [
[
[
312,
25,
1621
]
],
[
[
312,
21,
28809
],
[
28809,
60,
1621
]
],
[
[
312,
63,
1512
],
[
1512,
24,
1621
]
],
[
[
312,
24,
1274
],
[
1274... | [
[
[
"Eplerenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
]
],
[
[
"Eplerenone",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused by {... | Eplerenone (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Potassium chloride (Compound)
Eplerenone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00026 | DB06616 | 1,184 | 594 | [
"DDInter94",
"DDInter224"
] | Anakinra | Bosutinib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1184,
24,
594
]
],
[
[
1184,
24,
713
],
[
713,
63,
594
]
],
[
[
1184,
24,
663
],
[
663,
24,
594
]
],
[
[
1184,
63,
305
],
[
305,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate... |
DB05773 | DB09115 | 1,047 | 505 | [
"DDInter1848",
"DDInter559"
] | Trastuzumab emtansine | Diiodohydroxyquinoline | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
1047,
24,
505
]
],
[
[
1047,
24,
1593
],
[
1593,
24,
505
]
],
[
[
1047,
63,
467
],
[
467,
24,
505
]
],
[
[
1047,
25,
1510
],
[
1510,
... | [
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases whe... |
DB00470 | DB00472 | 530 | 758 | [
"DDInter601",
"DDInter758"
] | Dronabinol | Fluoxetine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Moderate | 1 | [
[
[
530,
24,
758
]
],
[
[
530,
24,
358
],
[
358,
1,
758
]
],
[
[
530,
24,
109
],
[
109,
40,
758
]
],
[
[
530,
6,
8374
],
[
8374,
45,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine (Compound) resembles Fluoxetine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compou... |
DB00678 | DB01222 | 240 | 617 | [
"DDInter1095",
"DDInter246"
] | Losartan | Budesonide | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
240,
24,
617
]
],
[
[
240,
63,
251
],
[
251,
1,
617
]
],
[
[
240,
24,
1220
],
[
1220,
1,
617
]
],
[
[
240,
6,
8374
],
[
8374,
45... | [
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
[
... | Losartan may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Losartan may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Budesonide (Co... |
DB00322 | DB00531 | 141 | 450 | [
"DDInter742",
"DDInter456"
] | Floxuridine | Cyclophosphamide | An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been... | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Moderate | 1 | [
[
[
141,
24,
450
]
],
[
[
141,
24,
1001
],
[
1001,
40,
450
]
],
[
[
141,
21,
28725
],
[
28725,
60,
450
]
],
[
[
141,
23,
956
],
[
956,
... | [
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclophosphamide"
]
],
[
[
"Floxuridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
... | Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine (Compound) resembles Cyclophosphamide (Compound)
Floxuridine (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Cyclophosphamide (Compound)
Floxuridine ma... |
DB00843 | DB09098 | 479 | 98 | [
"DDInter583",
"DDInter1700"
] | Donepezil | Somatrem | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
479,
24,
98
]
],
[
[
479,
23,
159
],
[
159,
63,
98
]
],
[
[
479,
63,
11
],
[
11,
24,
98
]
],
[
[
479,
23,
609
],
[
609,
24,
... | [
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Larotrectinib"
],
[
... | Donepezil may cause a minor interaction that can limit clinical effects when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Toremifene and Toremi... |
DB00640 | DB14568 | 1,585 | 982 | [
"DDInter31",
"DDInter1000"
] | Adenosine | Ivosidenib | The structure of adenosine was first described in 1931, though the vasodilating effects were not described in literature until the 1940s. Adenosine is indicated as an adjunct to thallium-201 in myocardial perfusion scintigraphy, though it is rarely used in this indication, having largely been replaced by [dipyridamole]... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1585,
25,
982
]
],
[
[
1585,
24,
1559
],
[
1559,
24,
982
]
],
[
[
1585,
23,
578
],
[
578,
24,
982
]
],
[
[
1585,
64,
11
],
[
11,
... | [
[
[
"Adenosine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Adenosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
],
[
"Famotidine",... | Adenosine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib
Adenosine may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagrelor... |
DB00757 | DB12141 | 1,166 | 971 | [
"DDInter581",
"DDInter817"
] | Dolasetron | Gilteritinib | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
1166,
25,
971
]
],
[
[
1166,
23,
1247
],
[
1247,
23,
971
]
],
[
[
1166,
64,
485
],
[
485,
24,
971
]
],
[
[
1166,
25,
1097
],
[
1097,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Dolasetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Dolasetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Dolasetron may lead to a major life threatening interaction when taken with Pentamidine and Pentamidin... |
DB00400 | DB12825 | 353 | 1,375 | [
"DDInter843",
"DDInter1032"
] | Griseofulvin | Lefamulin | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
353,
24,
1375
]
],
[
[
353,
24,
159
],
[
159,
63,
1375
]
],
[
[
353,
24,
309
],
[
309,
24,
1375
]
],
[
[
353,
62,
1101
],
[
1101,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone ... |
DB00159 | DB06822 | 940 | 802 | [
"DDInter903",
"DDInter1812"
] | Icosapent | Tinzaparin | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Moderate | 1 | [
[
[
940,
24,
802
]
],
[
[
940,
63,
1432
],
[
1432,
25,
802
]
],
[
[
940,
24,
1347
],
[
1347,
25,
802
]
],
[
[
940,
24,
498
],
[
498,
... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinzaparin"
]
],
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abciximab"
],
[
... | Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Abciximab and Abciximab may lead to a major life threatening interaction when taken with Tinzaparin
Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may lead to ... |
DB01030 | DB12893 | 869 | 586 | [
"DDInter1835",
"DDInter1629"
] | Topotecan | Sacituzumab govitecan | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab goviteca... | Moderate | 1 | [
[
[
869,
24,
586
]
],
[
[
869,
24,
270
],
[
270,
24,
586
]
],
[
[
869,
63,
58
],
[
58,
24,
586
]
],
[
[
869,
25,
1377
],
[
1377,
25,... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sacituzumab govitecan"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Sacituzumab govitecan
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Alefacept ... |
DB01284 | DB08907 | 1,042 | 1,344 | [
"DDInter1782",
"DDInter280"
] | Tetracosactide | Canagliflozin | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1042,
24,
1344
]
],
[
[
1042,
24,
549
],
[
549,
1,
1344
]
],
[
[
1042,
63,
1523
],
[
1523,
24,
1344
]
],
[
[
1042,
62,
1148
],
[
1148,... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol may cause a moderate interac... |
DB00819 | DB09472 | 471 | 1,383 | [
"DDInter15",
"DDInter1693"
] | Acetazolamide | Sodium sulfate | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
471,
24,
1383
]
],
[
[
471,
1,
997
],
[
997,
24,
1383
]
],
[
[
471,
23,
1264
],
[
1264,
24,
1383
]
],
[
[
471,
24,
657
],
[
657,
... | [
[
[
"Acetazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Acetazolamide",
"{u} (Compound) resembles {v} (Compound)",
"Methazolamide"
],
[
"Methazolamide",
"{u} may... | Acetazolamide (Compound) resembles Methazolamide (Compound) and Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Acetazolamide may cause a minor interaction that can limit clinical effects when taken with Doxepin and Doxepin may cause a moderate interaction th... |
DB00552 | DB06688 | 1,238 | 1,430 | [
"DDInter1425",
"DDInter1677"
] | Pentostatin | Sipuleucel-T | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
1238,
24,
1430
]
],
[
[
1238,
24,
51
],
[
51,
24,
1430
]
],
[
[
1238,
25,
676
],
[
676,
63,
1430
]
],
[
[
1238,
63,
589
],
[
589,
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Pentostatin may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitini... |
DB01177 | DB09268 | 77 | 1,662 | [
"DDInter904",
"DDInter1464"
] | Idarubicin | Picosulfuric acid | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
77,
24,
1662
]
],
[
[
77,
63,
1164
],
[
1164,
24,
1662
]
],
[
[
77,
24,
484
],
[
484,
63,
1662
]
],
[
[
77,
25,
1618
],
[
1618,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
],... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Entrectini... |
DB08918 | DB09080 | 41 | 144 | [
"DDInter1059",
"DDInter1331"
] | Levomilnacipran | Olodaterol | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
41,
24,
144
]
],
[
[
41,
63,
1445
],
[
1445,
24,
144
]
],
[
[
41,
64,
121
],
[
121,
24,
144
]
],
[
[
41,
1,
901
],
[
901,
24,
... | [
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Levomilnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
... | Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Levomilnacipran may lead to a major life threatening interaction when taken with Fenfluramine and... |
DB00704 | DB00802 | 267 | 1,322 | [
"DDInter1263",
"DDInter43"
] | Naltrexone | Alfentanil | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Major | 2 | [
[
[
267,
25,
1322
]
],
[
[
267,
25,
411
],
[
411,
1,
1322
]
],
[
[
267,
6,
6591
],
[
6591,
45,
1322
]
],
[
[
267,
21,
29118
],
[
29118,
... | [
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alfentanil"
]
],
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Remifentanil"
],
[
"Remifentanil",
"{... | Naltrexone may lead to a major life threatening interaction when taken with Remifentanil and Remifentanil (Compound) resembles Alfentanil (Compound)
Naltrexone (Compound) binds OPRM1 (Gene) and OPRM1 (Gene) is bound by Alfentanil (Compound)
Naltrexone (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Ef... |
DB01229 | DB06717 | 973 | 875 | [
"DDInter1378",
"DDInter778"
] | Paclitaxel (protein-bound) | Fosaprepitant | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
973,
24,
875
]
],
[
[
973,
63,
723
],
[
723,
1,
875
]
],
[
[
973,
21,
29340
],
[
29340,
60,
875
]
],
[
[
973,
63,
1101
],
[
1101,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Fosaprepitant
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Paclitaxel (Compound) causes Stevens-Johnson syndrom... |
DB00398 | DB01238 | 79 | 673 | [
"DDInter1702",
"DDInter118"
] | Sorafenib | Aripiprazole | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
79,
24,
673
]
],
[
[
79,
24,
827
],
[
827,
40,
673
]
],
[
[
79,
24,
1630
],
[
1630,
1,
673
]
],
[
[
79,
6,
21998
],
[
21998,
45,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Compou... |
DB00987 | DB10989 | 1,224 | 496 | [
"DDInter460",
"DDInter858"
] | Cytarabine | Hepatitis A Vaccine | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1224,
24,
496
]
],
[
[
1224,
24,
4
],
[
4,
24,
496
]
],
[
[
1224,
63,
147
],
[
147,
24,
496
]
],
[
[
1224,
24,
738
],
[
738,
63,... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesu... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Cytarabine may cause a moderate interaction that could exacerbate disease... |
DB00812 | DB11978 | 998 | 124 | [
"DDInter1451",
"DDInter822"
] | Phenylbutazone | Glasdegib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
998,
24,
124
]
],
[
[
998,
24,
1135
],
[
1135,
23,
124
]
],
[
[
998,
24,
466
],
[
466,
62,
124
]
],
[
[
998,
63,
79
],
[
79,
24,... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and D... |
DB00792 | DB14881 | 832 | 180 | [
"DDInter1878",
"DDInter1329"
] | Tripelennamine | Oliceridine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
832,
24,
180
]
],
[
[
832,
24,
401
],
[
401,
24,
180
]
],
[
[
832,
40,
649
],
[
649,
24,
180
]
],
[
[
832,
63,
85
],
[
85,
24,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Tripelennamine (Compound) resembles Clofedanol (Compound) and Clofedanol may cause a moderate interacti... |
DB01177 | DB12147 | 77 | 241 | [
"DDInter904",
"DDInter661"
] | Idarubicin | Erdafitinib | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
77,
24,
241
]
],
[
[
77,
24,
384
],
[
384,
24,
241
]
],
[
[
77,
25,
982
],
[
982,
63,
241
]
],
[
[
77,
64,
1425
],
[
1425,
24,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Idarubicin may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause... |
DB00059 | DB08908 | 1,560 | 713 | [
"DDInter1404",
"DDInter564"
] | Pegaspargase | Dimethyl fumarate | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1560,
24,
713
]
],
[
[
1560,
24,
996
],
[
996,
24,
713
]
],
[
[
1560,
24,
725
],
[
725,
63,
713
]
],
[
[
1560,
63,
268
],
[
268,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Satraliz... |
DB00450 | DB01269 | 78 | 38 | [
"DDInter603",
"DDInter1386"
] | Droperidol | Panitumumab | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Panitumumab (ABX-EGF) is a recombinant human IgG2 monoclonal antibody that binds specifically to the human epidermal growth factor receptor (EGFR). This drug is an antineoplastic agent. Panitumumab was granted FDA approval on 27 September 2006. | Major | 2 | [
[
[
78,
25,
38
]
],
[
[
78,
24,
384
],
[
384,
63,
38
]
],
[
[
78,
25,
1555
],
[
1555,
24,
38
]
],
[
[
78,
40,
1568
],
[
1568,
25,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panitumumab"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
[
"Idelalisi... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Panitumumab
Droperidol may lead to a major life threatening interaction when taken with Oxaliplatin and Oxaliplatin may cau... |
DB00726 | DB06663 | 1,164 | 1,154 | [
"DDInter1876",
"DDInter1398"
] | Trimipramine | Pasireotide | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1164,
25,
1154
]
],
[
[
1164,
63,
1314
],
[
1314,
40,
1154
]
],
[
[
1164,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1164,
23,
112
],
[
1... | [
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
"Des... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Pasireotide (Compound)
Trimipramine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Trimipramine may cause a... |
DB00570 | DB00834 | 147 | 932 | [
"DDInter1936",
"DDInter1215"
] | Vinblastine | Mifepristone | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
147,
24,
932
]
],
[
[
147,
6,
10417
],
[
10417,
45,
932
]
],
[
[
147,
7,
5196
],
[
5196,
46,
932
]
],
[
[
147,
18,
3798
],
[
3798,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound)... | Vinblastine (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Mifepristone (Compound)
Vinblastine (Compound) upregulates CBLB (Gene) and CBLB (Gene) is upregulated by Mifepristone (Compound)
Vinblastine (Compound) downregulates CAT (Gene) and CAT (Gene) is upregulated by Mifepristone (Compound)
Vinblastine (Co... |
DB00582 | DB00736 | 1,622 | 660 | [
"DDInter1946",
"DDInter676"
] | Voriconazole | Esomeprazole | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Moderate | 1 | [
[
[
1622,
24,
660
]
],
[
[
1622,
63,
1215
],
[
1215,
40,
660
]
],
[
[
1622,
24,
379
],
[
379,
40,
660
]
],
[
[
1622,
63,
837
],
[
837,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Esomeprazole (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole (Compound) resembles Esomeprazo... |
DB01045 | DB05351 | 463 | 101 | [
"DDInter1590",
"DDInter519"
] | Rifampicin | Dexlansoprazole | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
463,
24,
101
]
],
[
[
463,
24,
1069
],
[
1069,
23,
101
]
],
[
[
463,
63,
1347
],
[
1347,
23,
101
]
],
[
[
463,
25,
263
],
[
263,
... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
],
... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Vandetanib and Vandetanib may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Cl... |
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