drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00651 | DB09080 | 746 | 144 | [
"DDInter613",
"DDInter1331"
] | Dyphylline | Olodaterol | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
746,
24,
144
]
],
[
[
746,
25,
1592
],
[
1592,
24,
144
]
],
[
[
746,
24,
455
],
[
455,
24,
144
]
],
[
[
746,
23,
22
],
[
22,
24,... | [
[
[
"Dyphylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Dyphylline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nebivolol"
],
[
"Nebivolol",... | Dyphylline may lead to a major life threatening interaction when taken with Nebivolol and Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Dyphylline may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a ... |
DB01168 | DB01404 | 1,053 | 757 | [
"DDInter1526",
"DDInter820"
] | Procarbazine | Ginseng | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
1053,
24,
757
]
],
[
[
1053,
62,
126
],
[
126,
24,
757
]
],
[
[
1053,
21,
29024
],
[
29024,
60,
245
],
[
245,
24,
757
]
],
[
[
1053,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Procarbazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
],
[
... | Procarbazine may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Procarbazine (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Glimepiride (Comp... |
DB00852 | DB01200 | 1,445 | 469 | [
"DDInter1545",
"DDInter243"
] | Pseudoephedrine | Bromocriptine | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Moderate | 1 | [
[
[
1445,
24,
469
]
],
[
[
1445,
64,
1131
],
[
1131,
1,
469
]
],
[
[
1445,
25,
628
],
[
628,
1,
469
]
],
[
[
1445,
6,
5372
],
[
5372,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromocriptine"
]
],
[
[
"Pseudoephedrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methysergide"
],
[
... | Pseudoephedrine may lead to a major life threatening interaction when taken with Methysergide and Methysergide (Compound) resembles Bromocriptine (Compound)
Pseudoephedrine may lead to a major life threatening interaction when taken with Ergometrine and Ergometrine (Compound) resembles Bromocriptine (Compound)
Pseudoep... |
DB01155 | DB01268 | 872 | 1,151 | [
"DDInter813",
"DDInter1731"
] | Gemifloxacin | Sunitinib | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
872,
24,
1151
]
],
[
[
872,
21,
29662
],
[
29662,
60,
1151
]
],
[
[
872,
62,
112
],
[
112,
23,
1151
]
],
[
[
872,
63,
1148
],
[
1148,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Gemifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Candida infection"
],
[
"Candida infection",
"{u} (S... | Gemifloxacin (Compound) causes Candida infection (Side Effect) and Candida infection (Side Effect) is caused by Sunitinib (Compound)
Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects wh... |
DB08896 | DB15328 | 292 | 829 | [
"DDInter1576",
"DDInter1896"
] | Regorafenib | Ubrogepant | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Ubrogepant is indicated for the acute treatment of migraine headaches with or without aura in adults. It was approved by the FDA on December 23, 2019, and is the first oral calcitonin gene-related peptide (CGRP) receptor antagonist approved for the acute treatment of migraine. Several oral small molecule CGRP receptor ... | Moderate | 1 | [
[
[
292,
24,
829
]
],
[
[
292,
25,
1468
],
[
1468,
24,
829
]
],
[
[
292,
64,
578
],
[
578,
24,
829
]
],
[
[
292,
24,
26
],
[
26,
24,... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ubrogepant"
]
],
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib... | Regorafenib may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Ubrogepant
Regorafenib may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a moderate inte... |
DB00427 | DB01105 | 1,233 | 222 | [
"DDInter1879",
"DDInter1665"
] | Triprolidine | Sibutramine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1233,
24,
222
]
],
[
[
1233,
18,
7359
],
[
7359,
57,
222
]
],
[
[
1233,
24,
1563
],
[
1563,
24,
222
]
],
[
[
1233,
24,
733
],
[
733,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Triprolidine",
"{u} (Compound) downregulates {v} (Gene)",
"TXNDC9"
],
[
"TXNDC9",
"{u} (Gene) is downregulate... | Triprolidine (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Sibutramine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Halazepam and Halazepam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramin... |
DB00536 | DB08826 | 1,225 | 1,292 | [
"DDInter848",
"DDInter489"
] | Guanidine | Deferiprone | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1225,
25,
1292
]
],
[
[
1225,
21,
28809
],
[
28809,
60,
1292
]
],
[
[
1225,
24,
4
],
[
4,
25,
1292
]
],
[
[
1225,
64,
1064
],
[
1064,
... | [
[
[
"Guanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Guanidine",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side Effect) is caused by {v} (Compo... | Guanidine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Deferiprone (Compound)
Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may lead to a major life threatening interaction when take... |
DB04837 | DB14575 | 649 | 733 | [
"DDInter407",
"DDInter674"
] | Clofedanol | Eslicarbazepine | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
649,
24,
733
]
],
[
[
649,
63,
1264
],
[
1264,
24,
733
]
],
[
[
649,
24,
1609
],
[
1609,
24,
733
]
],
[
[
649,
1,
820
],
[
820,
... | [
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine
Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pent... |
DB00242 | DB11986 | 1,064 | 484 | [
"DDInter392",
"DDInter648"
] | Cladribine | Entrectinib | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1064,
24,
484
]
],
[
[
1064,
24,
466
],
[
466,
62,
484
]
],
[
[
1064,
24,
1197
],
[
1197,
24,
484
]
],
[
[
1064,
25,
510
],
[
510,
... | [
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and... |
DB00476 | DB06779 | 109 | 365 | [
"DDInter608",
"DDInter470"
] | Duloxetine | Dalteparin | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
109,
24,
365
]
],
[
[
109,
63,
305
],
[
305,
24,
365
]
],
[
[
109,
25,
1039
],
[
1039,
24,
365
]
],
[
[
109,
40,
758
],
[
758,
2... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia co... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Duloxetine may lead to a major life threatening interaction when taken wit... |
DB00731 | DB06335 | 1,144 | 761 | [
"DDInter1269",
"DDInter1646"
] | Nateglinide | Saxagliptin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1144,
24,
761
]
],
[
[
1144,
6,
7524
],
[
7524,
45,
761
]
],
[
[
1144,
21,
28966
],
[
28966,
60,
761
]
],
[
[
1144,
62,
1103
],
[
1103... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Nateglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound... | Nateglinide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Saxagliptin (Compound)
Nateglinide (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Nateglinide may cause a minor interaction that can limit c... |
DB01276 | DB14115 | 123 | 1,312 | [
"DDInter706",
"DDInter868"
] | Exenatide | Human botulinum neurotoxin A/B immune globulin | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Infant botulism is a rare infectious disease occurring in infants in which _Clostridium botulinum_ colonize the large intestine and being to produce botulinum neurotoxin directly in the gut. As these neurotoxins interfere with cholinergic nervous transmission, patients initially present with evident of loss of muscle t... | Moderate | 1 | [
[
[
123,
24,
1312
]
],
[
[
123,
63,
1132
],
[
1132,
25,
1312
]
],
[
[
123,
63,
1132
],
[
1132,
35,
416
],
[
416,
25,
1312
]
],
[
[
123,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human botulinum neurotoxin A/B immune globulin"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Gentamicin and Gentamicin may lead to a major life threatening interaction when taken with Human botulinum neurotoxin A/B immune globulin
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Ge... |
DB06441 | DB08918 | 936 | 41 | [
"DDInter283",
"DDInter1059"
] | Cangrelor | Levomilnacipran | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
936,
24,
41
]
],
[
[
936,
63,
901
],
[
901,
40,
41
]
],
[
[
936,
25,
498
],
[
498,
63,
41
]
],
[
[
936,
64,
330
],
[
330,
24,
... | [
[
[
"Cangrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Cangrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
],
... | Cangrelor may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Cangrelor may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a moderate interaction that could exacerbate di... |
DB00544 | DB14783 | 970 | 287 | [
"DDInter757",
"DDInter574"
] | Fluorouracil | Diroximel fumarate | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
970,
24,
287
]
],
[
[
970,
24,
384
],
[
384,
24,
287
]
],
[
[
970,
63,
599
],
[
599,
24,
287
]
],
[
[
970,
23,
147
],
[
147,
24,... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzum... |
DB00159 | DB00208 | 940 | 1,018 | [
"DDInter903",
"DDInter1804"
] | Icosapent | Ticlopidine | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Moderate | 1 | [
[
[
940,
24,
1018
]
],
[
[
940,
24,
1347
],
[
1347,
64,
1018
]
],
[
[
940,
18,
10375
],
[
10375,
57,
1018
]
],
[
[
940,
21,
28957
],
[
289... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
]
],
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
[
... | Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may lead to a major life threatening interaction when taken with Ticlopidine
Icosapent (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Ticlopidine (Compound)
Icosapent (Comp... |
DB00526 | DB00631 | 1,555 | 372 | [
"DDInter1355",
"DDInter405"
] | Oxaliplatin | Clofarabine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
1555,
24,
372
]
],
[
[
1555,
64,
1064
],
[
1064,
25,
372
]
],
[
[
1555,
24,
1488
],
[
1488,
40,
372
]
],
[
[
1555,
6,
17404
],
[
17404... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cladrib... | Oxaliplatin may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Clofarabine
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine (Compound) resembles... |
DB00285 | DB00792 | 1,100 | 832 | [
"DDInter1927",
"DDInter1878"
] | Venlafaxine | Tripelennamine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1100,
24,
832
]
],
[
[
1100,
24,
100
],
[
100,
63,
832
]
],
[
[
1100,
25,
1264
],
[
1264,
63,
832
]
],
[
[
1100,
24,
649
],
[
649,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Venlafaxine may lead to a major life threatening interaction when taken with Doxepin and Doxepin ... |
DB01132 | DB04865 | 1,130 | 4 | [
"DDInter1472",
"DDInter1335"
] | Pioglitazone | Omacetaxine mepesuccinate | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1130,
24,
4
]
],
[
[
1130,
18,
2475
],
[
2475,
46,
4
]
],
[
[
1130,
7,
4698
],
[
4698,
57,
4
]
],
[
[
1130,
63,
485
],
[
485,
24... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Pioglitazone",
"{u} (Compound) downregulates {v} (Gene)",
"RGS2"
],
[
"RGS2",
"{u} (Gene) is up... | Pioglitazone (Compound) downregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Pioglitazone (Compound) upregulates GPC1 (Gene) and GPC1 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Pioglitazone may cause a moderate interaction that could exacerbate diseases w... |
DB01050 | DB08901 | 848 | 1,468 | [
"DDInter900",
"DDInter1492"
] | Ibuprofen | Ponatinib | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
848,
25,
1468
]
],
[
[
848,
6,
3486
],
[
3486,
45,
1468
]
],
[
[
848,
6,
4789
],
[
4789,
57,
1468
]
],
[
[
848,
21,
29024
],
[
29024,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Ibuprofen",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Ponatinib"... | Ibuprofen (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ponatinib (Compound)
Ibuprofen (Compound) binds PPARG (Gene) and PPARG (Gene) is downregulated by Ponatinib (Compound)
Ibuprofen (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Ponatinib (Compound)
Ibuprofen ... |
DB00270 | DB04868 | 1,428 | 478 | [
"DDInter993",
"DDInter1293"
] | Isradipine | Nilotinib | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1428,
24,
478
]
],
[
[
1428,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1428,
7,
10670
],
[
10670,
46,
478
]
],
[
[
1428,
18,
8800
],
[
8800,... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Isradipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Isradipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Isradipine (Compound) upregulates KLHL21 (Gene) and KLHL21 (Gene) is upregulated by Nilotinib (Compound)
Isradipine (Compound) downregulates RBM34 (Gene) and RBM34 (Gene) is downregulated by Nilotinib (Compound)
Isradipine (Com... |
DB00539 | DB00934 | 11 | 413 | [
"DDInter1837",
"DDInter1124"
] | Toremifene | Maprotiline | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Major | 2 | [
[
[
11,
25,
413
]
],
[
[
11,
64,
1302
],
[
1302,
40,
413
]
],
[
[
11,
64,
847
],
[
847,
1,
413
]
],
[
[
11,
6,
4973
],
[
4973,
45,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Maprotiline"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Protriptyline"
],
[
"Protriptyline",
... | Toremifene may lead to a major life threatening interaction when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Toremifene may lead to a major life threatening interaction when taken with Atomoxetine and Atomoxetine (Compound) resembles Maprotiline (Compound)
Toremifene (Compound... |
DB00697 | DB06803 | 876 | 769 | [
"DDInter1821",
"DDInter1288"
] | Tizanidine | Niclosamide | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes... | Major | 2 | [
[
[
876,
25,
769
]
],
[
[
876,
6,
7950
],
[
7950,
45,
769
]
],
[
[
876,
18,
8386
],
[
8386,
46,
769
]
],
[
[
876,
18,
4930
],
[
4930,
... | [
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Niclosamide"
]
],
[
[
"Tizanidine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Niclos... | Tizanidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Niclosamide (Compound)
Tizanidine (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Niclosamide (Compound)
Tizanidine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Niclosamide (Compound)
Tizanidine ... |
DB00284 | DB01278 | 1,647 | 1,021 | [
"DDInter11",
"DDInter1506"
] | Acarbose | Pramlintide | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1647,
24,
1021
]
],
[
[
1647,
23,
1103
],
[
1103,
23,
1021
]
],
[
[
1647,
63,
1560
],
[
1560,
24,
1021
]
],
[
[
1647,
24,
1680
],
[
16... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Acarbose",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
[
"... | Acarbose may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Pramlintide
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargas... |
DB00883 | DB01143 | 426 | 923 | [
"DDInter989",
"DDInter65"
] | Isosorbide dinitrate | Amifostine | A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
426,
24,
923
]
],
[
[
426,
21,
28642
],
[
28642,
60,
923
]
],
[
[
426,
40,
1107
],
[
1107,
24,
923
]
],
[
[
426,
24,
714
],
[
714,
... | [
[
[
"Isosorbide dinitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Isosorbide dinitrate",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Eff... | Isosorbide dinitrate (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Isosorbide dinitrate (Compound) resembles Isosorbide mononitrate (Compound) and Isosorbide mononitrate may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Isosorbi... |
DB00559 | DB11901 | 152 | 913 | [
"DDInter223",
"DDInter107"
] | Bosentan | Apalutamide | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
152,
24,
913
]
],
[
[
152,
24,
112
],
[
112,
23,
913
]
],
[
[
152,
62,
608
],
[
608,
23,
913
]
],
[
[
152,
63,
600
],
[
600,
24,... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Bosentan may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocain... |
DB00342 | DB06595 | 1,181 | 1,491 | [
"DDInter1770",
"DDInter1214"
] | Terfenadine | Midostaurin | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
1181,
24,
1491
]
],
[
[
1181,
23,
112
],
[
112,
23,
1491
]
],
[
[
1181,
24,
888
],
[
888,
24,
1491
]
],
[
[
1181,
24,
1017
],
[
1017,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Ta... |
DB01067 | DB01193 | 959 | 819 | [
"DDInter826",
"DDInter12"
] | Glipizide | Acebutolol | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
959,
24,
819
]
],
[
[
959,
63,
887
],
[
887,
1,
819
]
],
[
[
959,
21,
28762
],
[
28762,
60,
819
]
],
[
[
959,
63,
417
],
[
417,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Glipizide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Acebutolol (Compound)
Glipizide may cause a moderate interaction that coul... |
DB00816 | DB11730 | 1,674 | 351 | [
"DDInter1346",
"DDInter1588"
] | Orciprenaline | Ribociclib | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1674,
25,
351
]
],
[
[
1674,
24,
222
],
[
222,
23,
351
]
],
[
[
1674,
63,
867
],
[
867,
24,
351
]
],
[
[
1674,
23,
1486
],
[
1486,
... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sib... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and ... |
DB00470 | DB01238 | 530 | 673 | [
"DDInter601",
"DDInter118"
] | Dronabinol | Aripiprazole | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
530,
24,
673
]
],
[
[
530,
24,
851
],
[
851,
1,
673
]
],
[
[
530,
24,
827
],
[
827,
40,
673
]
],
[
[
530,
6,
4973
],
[
4973,
45,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound... |
DB00305 | DB01097 | 377 | 1,377 | [
"DDInter1232",
"DDInter1033"
] | Mitomycin | Leflunomide | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
377,
25,
1377
]
],
[
[
377,
18,
4930
],
[
4930,
57,
1377
]
],
[
[
377,
21,
28701
],
[
28701,
60,
1377
]
],
[
[
377,
63,
1461
],
[
1461... | [
[
[
"Mitomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Mitomycin",
"{u} (Compound) downregulates {v} (Gene)",
"DLD"
],
[
"DLD",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Mitomycin (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Leflunomide (Compound)
Mitomycin (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Leflunomide (Compound)
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin ... |
DB00569 | DB06779 | 553 | 365 | [
"DDInter775",
"DDInter470"
] | Fondaparinux | Dalteparin | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Major | 2 | [
[
[
553,
25,
365
]
],
[
[
553,
23,
539
],
[
539,
62,
365
]
],
[
[
553,
63,
305
],
[
305,
24,
365
]
],
[
[
553,
24,
1496
],
[
1496,
6... | [
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalteparin"
]
],
[
[
"Fondaparinux",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",... | Fondaparinux may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Dalteparin
Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia ... |
DB00450 | DB06788 | 78 | 1,616 | [
"DDInter603",
"DDInter864"
] | Droperidol | Histrelin | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
78,
25,
1616
]
],
[
[
78,
23,
112
],
[
112,
23,
1616
]
],
[
[
78,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
78,
24,
603
],
[
603,
63... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Droperidol may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may cause... |
DB00459 | DB09389 | 640 | 517 | [
"DDInter21",
"DDInter1315"
] | Acitretin | Norgestrel | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Major | 2 | [
[
[
640,
25,
517
]
],
[
[
640,
25,
1517
],
[
1517,
24,
517
]
],
[
[
640,
24,
1411
],
[
1411,
24,
517
]
],
[
[
640,
63,
305
],
[
305,
... | [
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norgestrel"
]
],
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isotretinoin"
],
[
"Isotretinoin",
"{u}... | Acitretin may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may ca... |
DB00047 | DB00574 | 176 | 121 | [
"DDInter932",
"DDInter717"
] | Insulin glargine | Fenfluramine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
176,
24,
121
]
],
[
[
176,
24,
127
],
[
127,
24,
121
]
],
[
[
176,
24,
659
],
[
659,
63,
121
]
],
[
[
176,
24,
341
],
[
341,
64,... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol ... |
DB00026 | DB11952 | 1,184 | 800 | [
"DDInter94",
"DDInter612"
] | Anakinra | Duvelisib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
1184,
24,
800
]
],
[
[
1184,
24,
310
],
[
310,
24,
800
]
],
[
[
1184,
24,
1476
],
[
1476,
63,
800
]
],
[
[
1184,
25,
1292
],
[
1292,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatini... |
DB00414 | DB00501 | 590 | 752 | [
"DDInter16",
"DDInter380"
] | Acetohexamide | Cimetidine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Moderate | 1 | [
[
[
590,
24,
752
]
],
[
[
590,
24,
935
],
[
935,
62,
752
]
],
[
[
590,
63,
831
],
[
831,
23,
752
]
],
[
[
590,
24,
886
],
[
886,
23,... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a minor interaction that can limit clinical effects when taken with Cimetidine
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and ... |
DB00270 | DB09133 | 1,428 | 1,527 | [
"DDInter993",
"DDInter965"
] | Isradipine | Iothalamic acid | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
1428,
24,
1527
]
],
[
[
1428,
24,
278
],
[
278,
63,
1527
]
],
[
[
1428,
1,
84
],
[
84,
24,
1527
]
],
[
[
1428,
24,
512
],
[
512,
... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
],
... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid and Iopodic acid may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Isradipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction... |
DB00574 | DB01132 | 121 | 1,130 | [
"DDInter717",
"DDInter1472"
] | Fenfluramine | Pioglitazone | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
121,
24,
1130
]
],
[
[
121,
25,
851
],
[
851,
63,
1130
]
],
[
[
121,
24,
688
],
[
688,
24,
1130
]
],
[
[
121,
24,
320
],
[
320,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
],
[
"Nefa... | Fenfluramine may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone
Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may ... |
DB00934 | DB00938 | 413 | 455 | [
"DDInter1124",
"DDInter1635"
] | Maprotiline | Salmeterol | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
413,
24,
455
]
],
[
[
413,
24,
688
],
[
688,
63,
455
]
],
[
[
413,
7,
9650
],
[
9650,
46,
455
]
],
[
[
413,
18,
2183
],
[
2183,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Maprotiline (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Salmeterol (Compound)
Mapr... |
DB00902 | DB11827 | 104 | 433 | [
"DDInter1168",
"DDInter669"
] | Methdilazine | Ertugliflozin | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
104,
24,
433
]
],
[
[
104,
63,
1020
],
[
1020,
24,
433
]
],
[
[
104,
24,
959
],
[
959,
24,
433
]
],
[
[
104,
40,
820
],
[
820,
2... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Gl... |
DB00252 | DB09481 | 362 | 460 | [
"DDInter1460",
"DDInter1113"
] | Phenytoin | Magnesium carbonate | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
362,
24,
460
]
],
[
[
362,
24,
401
],
[
401,
23,
460
]
],
[
[
362,
25,
752
],
[
752,
23,
460
]
],
[
[
362,
63,
1018
],
[
1018,
2... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Phenytoin may lead to a major life threatening interaction when taken with Cimetidine and Cimetidine m... |
DB00557 | DB11718 | 252 | 927 | [
"DDInter895",
"DDInter640"
] | Hydroxyzine | Encorafenib | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
252,
24,
927
]
],
[
[
252,
23,
112
],
[
112,
23,
927
]
],
[
[
252,
24,
720
],
[
720,
24,
927
]
],
[
[
252,
63,
1010
],
[
1010,
2... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Hydroxyzine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil and ... |
DB06605 | DB12825 | 1,409 | 1,375 | [
"DDInter108",
"DDInter1032"
] | Apixaban | Lefamulin | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
1409,
24,
1375
]
],
[
[
1409,
24,
159
],
[
159,
63,
1375
]
],
[
[
1409,
63,
1101
],
[
1101,
24,
1375
]
],
[
[
1409,
24,
98
],
[
98,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexar... |
DB00434 | DB00502 | 13 | 1,300 | [
"DDInter459",
"DDInter853"
] | Cyproheptadine | Haloperidol | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Moderate | 1 | [
[
[
13,
24,
1300
]
],
[
[
13,
24,
78
],
[
78,
1,
1300
]
],
[
[
13,
24,
543
],
[
543,
63,
1300
]
],
[
[
13,
63,
1242
],
[
1242,
24,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Haloperidol"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
],... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Haloperidol (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction t... |
DB00902 | DB01142 | 104 | 1,264 | [
"DDInter1168",
"DDInter593"
] | Methdilazine | Doxepin | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
104,
24,
1264
]
],
[
[
104,
40,
508
],
[
508,
24,
1264
]
],
[
[
104,
24,
401
],
[
401,
24,
1264
]
],
[
[
104,
63,
1594
],
[
1594,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Methdilazine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause a moderate... | Methdilazine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that co... |
DB00262 | DB15091 | 552 | 676 | [
"DDInter302",
"DDInter1901"
] | Carmustine | Upadacitinib | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
552,
25,
676
]
],
[
[
552,
63,
1461
],
[
1461,
23,
676
]
],
[
[
552,
24,
1430
],
[
1430,
24,
676
]
],
[
[
552,
25,
752
],
[
752,
... | [
[
[
"Carmustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipule... |
DB00041 | DB00524 | 1,648 | 811 | [
"DDInter38",
"DDInter1199"
] | Aldesleukin | Metolazone | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Moderate | 1 | [
[
[
1648,
24,
811
]
],
[
[
1648,
24,
1605
],
[
1605,
40,
811
]
],
[
[
1648,
24,
1014
],
[
1014,
1,
811
]
],
[
[
1648,
24,
1042
],
[
1042,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Metolazone (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Metolazone (Comp... |
DB00258 | DB09100 | 666 | 320 | [
"DDInter270",
"DDInter1799"
] | Calcium acetate | Thyroid, porcine | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
666,
24,
320
]
],
[
[
666,
24,
1231
],
[
1231,
24,
320
]
],
[
[
666,
21,
28845
],
[
28845,
60,
417
],
[
417,
23,
320
]
],
[
[
666,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer and Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine
Calcium acetate (Compound) causes Oedema (Side Effect) and Oedema (Side Effect) is caused by Sucralfate... |
DB00041 | DB00741 | 1,648 | 167 | [
"DDInter38",
"DDInter885"
] | Aldesleukin | Hydrocortisone | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1648,
24,
167
]
],
[
[
1648,
24,
1220
],
[
1220,
40,
167
]
],
[
[
1648,
24,
443
],
[
443,
24,
167
]
],
[
[
1648,
24,
1364
],
[
1364,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate in... |
DB01267 | DB12141 | 519 | 971 | [
"DDInter1381",
"DDInter817"
] | Paliperidone | Gilteritinib | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
519,
24,
971
]
],
[
[
519,
62,
112
],
[
112,
23,
971
]
],
[
[
519,
63,
485
],
[
485,
24,
971
]
],
[
[
519,
24,
823
],
[
823,
63,... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Paliperidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine a... |
DB06043 | DB11003 | 1,644 | 748 | [
"DDInter1328",
"DDInter100"
] | Olaratumab | Anthrax vaccine | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1644,
24,
748
]
],
[
[
1644,
25,
676
],
[
676,
63,
748
]
],
[
[
1644,
63,
1683
],
[
1683,
24,
748
]
],
[
[
1644,
64,
1057
],
[
1057,
... | [
[
[
"Olaratumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Olaratumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
"Upa... | Olaratumab may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Olaratumab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab... |
DB00694 | DB06788 | 51 | 1,616 | [
"DDInter485",
"DDInter864"
] | Daunorubicin | Histrelin | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
51,
24,
1616
]
],
[
[
51,
23,
112
],
[
112,
23,
1616
]
],
[
[
51,
24,
1664
],
[
1664,
24,
1616
]
],
[
[
51,
35,
77
],
[
77,
24,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and ... |
DB00526 | DB11986 | 1,555 | 484 | [
"DDInter1355",
"DDInter648"
] | Oxaliplatin | Entrectinib | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1555,
24,
484
]
],
[
[
1555,
23,
1247
],
[
1247,
23,
484
]
],
[
[
1555,
24,
112
],
[
112,
23,
484
]
],
[
[
1555,
24,
1539
],
[
1539,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Oxaliplatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Oxaliplatin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidaz... |
DB00757 | DB01224 | 1,166 | 623 | [
"DDInter581",
"DDInter1553"
] | Dolasetron | Quetiapine | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Major | 2 | [
[
[
1166,
25,
623
]
],
[
[
1166,
64,
827
],
[
827,
1,
623
]
],
[
[
1166,
25,
851
],
[
851,
1,
623
]
],
[
[
1166,
63,
867
],
[
867,
1... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quetiapine"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trazodone"
],
[
"Trazodone",
"{u} (Co... | Dolasetron may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone (Compound) resembles Quetiapine (Compound)
Dolasetron may cause a moderate ... |
DB00397 | DB06335 | 1,466 | 761 | [
"DDInter1458",
"DDInter1646"
] | Phenylpropanolamine | Saxagliptin | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1466,
24,
761
]
],
[
[
1466,
21,
28722
],
[
28722,
60,
761
]
],
[
[
1466,
24,
104
],
[
104,
24,
761
]
],
[
[
1466,
24,
1296
],
[
1296,... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Ef... | Phenylpropanolamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when t... |
DB00254 | DB00564 | 964 | 1,236 | [
"DDInter598",
"DDInter293"
] | Doxycycline | Carbamazepine | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
964,
24,
1236
]
],
[
[
964,
63,
362
],
[
362,
1,
1236
]
],
[
[
964,
6,
8374
],
[
8374,
45,
1236
]
],
[
[
964,
24,
1031
],
[
1031,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carbamazepine (Compound)
Doxycycline may cause a moderate interaction that could exac... |
DB08881 | DB11642 | 868 | 938 | [
"DDInter1925",
"DDInter1480"
] | Vemurafenib | Pitolisant | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Major | 2 | [
[
[
868,
25,
938
]
],
[
[
868,
62,
112
],
[
112,
23,
938
]
],
[
[
868,
24,
760
],
[
760,
24,
938
]
],
[
[
868,
64,
600
],
[
600,
24,... | [
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pitolisant"
]
],
[
[
"Vemurafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Vemurafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Co... |
DB00289 | DB00581 | 847 | 355 | [
"DDInter132",
"DDInter1018"
] | Atomoxetine | Lactulose | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
847,
24,
355
]
],
[
[
847,
21,
28750
],
[
28750,
60,
355
]
],
[
[
847,
24,
286
],
[
286,
62,
355
]
],
[
[
847,
24,
79
],
[
79,
2... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Atomoxetine",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal discomfort"
],
[
"Abdominal discomfort",
"{u... | Atomoxetine (Compound) causes Abdominal discomfort (Side Effect) and Abdominal discomfort (Side Effect) is caused by Lactulose (Compound)
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit c... |
DB06605 | DB09034 | 1,409 | 1,313 | [
"DDInter108",
"DDInter1733"
] | Apixaban | Suvorexant | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
1409,
24,
1313
]
],
[
[
1409,
64,
1213
],
[
1213,
24,
1313
]
],
[
[
1409,
24,
1619
],
[
1619,
63,
1313
]
],
[
[
1409,
63,
353
],
[
353... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib",
... | Apixaban may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Suvorexant
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a modera... |
DB09121 | DB12834 | 1,328 | 148 | [
"DDInter140",
"DDInter1649"
] | Aurothioglucose | Secnidazole | Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis. The use of gold compounds has decreased sin... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
1328,
24,
148
]
],
[
[
1328,
63,
1593
],
[
1593,
24,
148
]
],
[
[
1328,
24,
1480
],
[
1480,
24,
148
]
],
[
[
1328,
64,
1487
],
[
1487,... | [
[
[
"Aurothioglucose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Aurothioglucose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Aurothioglucose may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Aurothioglucose may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib a... |
DB00682 | DB01598 | 126 | 483 | [
"DDInter1951",
"DDInter911"
] | Warfarin | Imipenem | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Imipenem is a semisynthetic thienamycin that has a wide spectrum of antibacterial activity against gram-negative and gram-positive aerobic and anaerobic bacteria, including many multiresistant strains.[label] It is stable to many beta-lactamases. Similar compounds include [meropenem], known for having greater activity ... | Moderate | 1 | [
[
[
126,
24,
483
]
],
[
[
126,
24,
593
],
[
593,
25,
483
]
],
[
[
126,
62,
1533
],
[
1533,
7,
13852
],
[
13852,
46,
483
]
],
[
[
126,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imipenem"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
],
[
"Bu... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Bupropion and Bupropion may lead to a major life threatening interaction when taken with Imipenem
Warfarin may cause a minor interaction that can limit clinical effects when taken with Entacapone and Entacapone (Compound) upregulat... |
DB08907 | DB13007 | 1,344 | 1,060 | [
"DDInter280",
"DDInter642"
] | Canagliflozin | Enfortumab vedotin | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
1344,
24,
1060
]
],
[
[
1344,
63,
590
],
[
590,
24,
1060
]
],
[
[
1344,
40,
549
],
[
549,
24,
1060
]
],
[
[
1344,
24,
1296
],
[
1296,
... | [
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide... | Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Canagliflozin (Compound) resembles Dapagliflozin (Compound) and Dapagliflozin may cause a moder... |
DB00055 | DB01166 | 834 | 477 | [
"DDInter605",
"DDInter379"
] | Drotrecogin alfa | Cilostazol | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Major | 2 | [
[
[
834,
25,
477
]
],
[
[
834,
25,
126
],
[
126,
23,
477
]
],
[
[
834,
23,
539
],
[
539,
62,
477
]
],
[
[
834,
24,
109
],
[
109,
24,... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warfarin",
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause ... |
DB00490 | DB09098 | 946 | 98 | [
"DDInter254",
"DDInter1700"
] | Buspirone | Somatrem | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
946,
24,
98
]
],
[
[
946,
24,
159
],
[
159,
63,
98
]
],
[
[
946,
24,
609
],
[
609,
24,
98
]
],
[
[
946,
25,
222
],
[
222,
24,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and ... |
DB00683 | DB08904 | 1,382 | 375 | [
"DDInter1212",
"DDInter342"
] | Midazolam | Certolizumab pegol | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
1382,
24,
375
]
],
[
[
1382,
24,
1593
],
[
1593,
24,
375
]
],
[
[
1382,
63,
608
],
[
608,
24,
375
]
],
[
[
1382,
1,
902
],
[
902,
... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
... | Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and L... |
DB08816 | DB09075 | 578 | 498 | [
"DDInter1802",
"DDInter621"
] | Ticagrelor | Edoxaban | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
578,
25,
498
]
],
[
[
578,
23,
944
],
[
944,
62,
498
]
],
[
[
578,
24,
1004
],
[
1004,
63,
498
]
],
[
[
578,
24,
41
],
[
41,
24,... | [
[
[
"Ticagrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Ticagrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl ... |
DB01101 | DB10315 | 60 | 1,137 | [
"DDInter285",
"DDInter1127"
] | Capecitabine | Measles virus vaccine live attenuated | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
60,
25,
1137
]
],
[
[
60,
64,
581
],
[
581,
25,
1137
]
],
[
[
60,
24,
384
],
[
384,
25,
1137
]
],
[
[
60,
63,
1184
],
[
1184,
25... | [
[
[
"Capecitabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Capecitabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Capecitabine may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idela... |
DB01044 | DB08881 | 246 | 868 | [
"DDInter809",
"DDInter1925"
] | Gatifloxacin | Vemurafenib | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
246,
25,
868
]
],
[
[
246,
6,
1829
],
[
1829,
45,
868
]
],
[
[
246,
7,
2067
],
[
2067,
46,
868
]
],
[
[
246,
18,
8386
],
[
8386,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
"Vemurafe... | Gatifloxacin (Compound) binds ALB (Gene) and ALB (Gene) is bound by Vemurafenib (Compound)
Gatifloxacin (Compound) upregulates IKBKB (Gene) and IKBKB (Gene) is upregulated by Vemurafenib (Compound)
Gatifloxacin (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Vemurafenib (Compound)
Gatifloxaci... |
DB08895 | DB14881 | 976 | 180 | [
"DDInter1825",
"DDInter1329"
] | Tofacitinib | Oliceridine | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
976,
24,
180
]
],
[
[
976,
64,
1184
],
[
1184,
24,
180
]
],
[
[
976,
25,
1476
],
[
1476,
24,
180
]
],
[
[
976,
24,
1297
],
[
1297,
... | [
[
[
"Tofacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Tofacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anakinra"
],
[
"Anakinra"... | Tofacitinib may lead to a major life threatening interaction when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Tofacitinib may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate inter... |
DB00312 | DB11979 | 1,023 | 1,320 | [
"DDInter1423",
"DDInter625"
] | Pentobarbital | Elagolix | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1023,
24,
1320
]
],
[
[
1023,
62,
168
],
[
168,
23,
1320
]
],
[
[
1023,
24,
1297
],
[
1297,
24,
1320
]
],
[
[
1023,
24,
877
],
[
877,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Pentobarbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Pentobarbital may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Osilodrostat and Osil... |
DB00860 | DB09263 | 891 | 1,436 | [
"DDInter1513",
"DDInter1399"
] | Prednisolone | Patiromer | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
891,
24,
1436
]
],
[
[
891,
40,
1220
],
[
1220,
24,
1436
]
],
[
[
891,
23,
1114
],
[
1114,
63,
1436
]
],
[
[
891,
63,
1645
],
[
1645,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexamethasone",
"{u} may cause ... | Prednisolone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a moderate interaction... |
DB00877 | DB15093 | 629 | 1,654 | [
"DDInter1678",
"DDInter1698"
] | Sirolimus | Somapacitan | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
629,
24,
1654
]
],
[
[
629,
63,
608
],
[
608,
23,
1654
]
],
[
[
629,
63,
10
],
[
10,
24,
1654
]
],
[
[
629,
24,
433
],
[
433,
24... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somapacitan
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapsone may ca... |
DB00884 | DB09481 | 1,008 | 460 | [
"DDInter1604",
"DDInter1113"
] | Risedronic acid | Magnesium carbonate | Risedronic acid is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
1008,
24,
460
]
],
[
[
1008,
24,
853
],
[
853,
24,
460
]
],
[
[
1008,
24,
428
],
[
428,
63,
460
]
],
[
[
1008,
40,
1485
],
[
1485,
... | [
[
[
"Risedronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Risedronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesiu... | Risedronic acid may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride and Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium carbonate
Risedronic acid may cause a moderate interaction that could exacerbate diseases wh... |
DB04845 | DB11003 | 309 | 748 | [
"DDInter1001",
"DDInter100"
] | Ixabepilone | Anthrax vaccine | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
309,
24,
748
]
],
[
[
309,
63,
168
],
[
168,
24,
748
]
],
[
[
309,
25,
676
],
[
676,
63,
748
]
],
[
[
309,
24,
1683
],
[
1683,
2... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Ixabepilone may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib... |
DB00446 | DB01177 | 597 | 77 | [
"DDInter351",
"DDInter904"
] | Chloramphenicol | Idarubicin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
597,
24,
77
]
],
[
[
597,
6,
6017
],
[
6017,
45,
77
]
],
[
[
597,
7,
2903
],
[
2903,
46,
77
]
],
[
[
597,
18,
8527
],
[
8527,
57... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (C... | Chloramphenicol (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Chloramphenicol (Compound) upregulates MMP1 (Gene) and MMP1 (Gene) is upregulated by Idarubicin (Compound)
Chloramphenicol (Compound) downregulates UBE2S (Gene) and UBE2S (Gene) is downregulated by Idarubicin (Compound)
C... |
DB00188 | DB00330 | 168 | 238 | [
"DDInter222",
"DDInter689"
] | Bortezomib | Ethambutol | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Moderate | 1 | [
[
[
168,
24,
238
]
],
[
[
168,
7,
10670
],
[
10670,
46,
238
]
],
[
[
168,
21,
29062
],
[
29062,
60,
238
]
],
[
[
168,
64,
1057
],
[
1057,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethambutol"
]
],
[
[
"Bortezomib",
"{u} (Compound) upregulates {v} (Gene)",
"KLHL21"
],
[
"KLHL21",
"{u} (Gene) is upregulated by {v} ... | Bortezomib (Compound) upregulates KLHL21 (Gene) and KLHL21 (Gene) is upregulated by Ethambutol (Compound)
Bortezomib (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Ethambutol (Compound)
Bortezomib may lead to a major life threatening interaction when taken with Etanercept and Eta... |
DB00622 | DB06273 | 1,081 | 980 | [
"DDInter1287",
"DDInter1824"
] | Nicardipine | Tocilizumab | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1081,
24,
980
]
],
[
[
1081,
40,
1428
],
[
1428,
24,
980
]
],
[
[
1081,
24,
629
],
[
629,
24,
980
]
],
[
[
1081,
63,
58
],
[
58,
... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Nicardipine",
"{u} (Compound) resembles {v} (Compound)",
"Isradipine"
],
[
"Isradipine",
"{u} may cause a mode... | Nicardipine (Compound) resembles Isradipine (Compound) and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that coul... |
DB01246 | DB14740 | 820 | 771 | [
"DDInter45",
"DDInter881"
] | Alimemazine | Hyaluronidase | A phenothiazine derivative that is used as an antipruritic. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
820,
23,
771
]
],
[
[
820,
24,
849
],
[
849,
23,
771
]
],
[
[
820,
63,
1242
],
[
1242,
23,
771
]
],
[
[
820,
74,
1376
],
[
1376,
... | [
[
[
"Alimemazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cet... |
DB01234 | DB09082 | 1,220 | 659 | [
"DDInter513",
"DDInter1934"
] | Dexamethasone | Vilanterol | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Minor | 0 | [
[
[
1220,
23,
659
]
],
[
[
1220,
1,
891
],
[
891,
23,
659
]
],
[
[
1220,
40,
1573
],
[
1573,
23,
659
]
],
[
[
1220,
24,
1296
],
[
1296,
... | [
[
[
"Dexamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vilanterol"
]
],
[
[
"Dexamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Prednisolone"
],
[
"Prednisolone",
"{u} may cause a... | Dexamethasone (Compound) resembles Prednisolone (Compound) and Prednisolone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Dexamethasone (Compound) resembles Prednisone (Compound) and Prednisone may cause a minor interaction that can limit clinical effects when taken with Vilan... |
DB00777 | DB06704 | 146 | 247 | [
"DDInter1537",
"DDInter951"
] | Propiomazine | Iobenguane (I-123) | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
146,
24,
247
]
],
[
[
146,
40,
820
],
[
820,
24,
247
]
],
[
[
146,
1,
104
],
[
104,
24,
247
]
],
[
[
146,
25,
497
],
[
497,
25,
... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Propiomazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
"{u} may cause a m... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Propiomazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Propiomazine (Compound) resembles Methdilazine (Comp... |
DB00372 | DB06691 | 999 | 849 | [
"DDInter1793",
"DDInter1155"
] | Thiethylperazine | Mepyramine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
999,
24,
849
]
],
[
[
999,
63,
1594
],
[
1594,
24,
849
]
],
[
[
999,
24,
272
],
[
272,
24,
849
]
],
[
[
999,
24,
1116
],
[
1116,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Chlorphen... |
DB11793 | DB11817 | 738 | 1,259 | [
"DDInter1297",
"DDInter165"
] | Niraparib | Baricitinib | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
738,
25,
1259
]
],
[
[
738,
63,
1274
],
[
1274,
24,
1259
]
],
[
[
738,
24,
1129
],
[
1129,
63,
1259
]
],
[
[
738,
63,
384
],
[
384,
... | [
[
[
"Niraparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
[
"Flurbipro... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e... |
DB00432 | DB01610 | 1,083 | 248 | [
"DDInter1868",
"DDInter1912"
] | Trifluridine | Valganciclovir | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
1083,
24,
248
]
],
[
[
1083,
24,
563
],
[
563,
1,
248
]
],
[
[
1083,
54,
19128
],
[
19128,
15,
248
]
],
[
[
1083,
21,
28719
],
[
28719... | [
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],... | Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Trifluridine (Compound) is included by Nucleoside Analog (Pharmacologic Class) and Nucleoside Analog (Pharmacologic Class) includes Valganciclovir (Comp... |
DB00196 | DB01045 | 600 | 463 | [
"DDInter743",
"DDInter1590"
] | Fluconazole | Rifampicin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Major | 2 | [
[
[
600,
25,
463
]
],
[
[
600,
24,
690
],
[
690,
40,
463
]
],
[
[
600,
6,
10215
],
[
10215,
45,
463
]
],
[
[
600,
24,
1264
],
[
1264,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rifampicin"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
"Rifabutin... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Fluconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Rifampicin (Compound)
Fluconazole may cause a moderate interaction that could exacerba... |
DB00350 | DB01068 | 1,214 | 1,565 | [
"DDInter1226",
"DDInter411"
] | Minoxidil | Clonazepam | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Moderate | 1 | [
[
[
1214,
24,
1565
]
],
[
[
1214,
24,
1382
],
[
1382,
1,
1565
]
],
[
[
1214,
24,
1216
],
[
1216,
40,
1565
]
],
[
[
1214,
63,
905
],
[
905,... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonazepam"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Clonazepam (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Clonazepam (Compound)
Mino... |
DB00225 | DB00489 | 457 | 17 | [
"DDInter794",
"DDInter1704"
] | Gadodiamide | Sotalol | Gadodiamide is a linear, non-ionic gadolinium-based contrast agent (GBCA) that is used in magnetic resonance imaging (MRI) procedures to assist in the visualization of blood vessels.[A263086,A263091] GBCAs constitute the largest group of MR agents, and they are thought to be safer than nonionic iodinated contrast agent... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
457,
24,
17
]
],
[
[
457,
24,
88
],
[
88,
40,
17
]
],
[
[
457,
21,
28719
],
[
28719,
60,
17
]
],
[
[
457,
40,
1431
],
[
1431,
63... | [
[
[
"Gadodiamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Gadodiamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],
[
... | Gadodiamide may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Gadodiamide (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sotalol (Compound)
Gadodiamide (Compound) resembles Gadopentetic acid (Compou... |
DB00987 | DB06168 | 1,224 | 1,531 | [
"DDInter460",
"DDInter281"
] | Cytarabine | Canakinumab | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
1224,
24,
1531
]
],
[
[
1224,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
1224,
63,
377
],
[
377,
24,
1531
]
],
[
[
1224,
24,
1270
],
[
1270... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin ... |
DB01244 | DB06603 | 762 | 39 | [
"DDInter192",
"DDInter1387"
] | Bepridil | Panobinostat | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
762,
25,
39
]
],
[
[
762,
62,
112
],
[
112,
23,
39
]
],
[
[
762,
63,
455
],
[
455,
24,
39
]
],
[
[
762,
24,
578
],
[
578,
63,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Bepridil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Bepridil may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmet... |
DB00889 | DB12887 | 1,133 | 1,598 | [
"DDInter840",
"DDInter1750"
] | Granisetron | Tazemetostat | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
1133,
24,
1598
]
],
[
[
1133,
24,
594
],
[
594,
24,
1598
]
],
[
[
1133,
25,
985
],
[
985,
24,
1598
]
],
[
[
1133,
63,
888
],
[
888,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
],
[... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Granisetron may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may ca... |
DB06723 | DB12147 | 115 | 241 | [
"DDInter58",
"DDInter661"
] | Aluminum hydroxide | Erdafitinib | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Major | 2 | [
[
[
115,
25,
241
]
],
[
[
115,
63,
478
],
[
478,
24,
241
]
],
[
[
115,
62,
1220
],
[
1220,
25,
241
]
],
[
[
115,
64,
1196
],
[
1196,
... | [
[
[
"Aluminum hydroxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erdafitinib"
]
],
[
[
"Aluminum hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Aluminum hydroxide may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Aluminum hydroxide may cause a minor interaction that can limit clinical effects when taken with Dexameth... |
DB10795 | DB11988 | 221 | 270 | [
"DDInter1486",
"DDInter1321"
] | Poliovirus type 1 antigen (formaldehyde inactivated) | Ocrelizumab | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
221,
24,
270
]
],
[
[
221,
63,
134
],
[
134,
24,
270
]
],
[
[
221,
24,
1019
],
[
1019,
24,
270
]
],
[
[
221,
24,
398
],
[
398,
6... | [
[
[
"Poliovirus type 1 antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Poliovirus type 1 antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction th... | Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Poliovirus type 1 antigen (formaldehyde inactivated) may cause a mo... |
DB00911 | DB15965 | 458 | 1,330 | [
"DDInter1811",
"DDInter1270"
] | Tinidazole | Naxitamab | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
458,
24,
1330
]
],
[
[
458,
24,
14
],
[
14,
24,
1330
]
],
[
[
458,
63,
10
],
[
10,
24,
1330
]
],
[
[
458,
40,
112
],
[
112,
24,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapson... |
DB01394 | DB09570 | 1,554 | 1,480 | [
"DDInter431",
"DDInter1002"
] | Colchicine | Ixazomib | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1554,
24,
1480
]
],
[
[
1554,
63,
268
],
[
268,
24,
1480
]
],
[
[
1554,
24,
148
],
[
148,
63,
1480
]
],
[
[
1554,
24,
98
],
[
98,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Colchicine may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB00836 | DB00872 | 543 | 1,080 | [
"DDInter1088",
"DDInter438"
] | Loperamide | Conivaptan | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Major | 2 | [
[
[
543,
25,
1080
]
],
[
[
543,
24,
165
],
[
165,
40,
1080
]
],
[
[
543,
6,
8374
],
[
8374,
45,
1080
]
],
[
[
543,
21,
28646
],
[
28646,
... | [
[
[
"Loperamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[
"Tolvaptan",... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan (Compound) resembles Conivaptan (Compound)
Loperamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Conivaptan (Compound)
Loperamide (Compound) causes Unspecified disorder of skin and subcut... |
DB00631 | DB00738 | 372 | 485 | [
"DDInter405",
"DDInter1420"
] | Clofarabine | Pentamidine | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
372,
24,
485
]
],
[
[
372,
24,
1423
],
[
1423,
1,
485
]
],
[
[
372,
7,
5295
],
[
5295,
46,
485
]
],
[
[
372,
7,
4071
],
[
4071,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ospemifene"
],
[... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ospemifene and Ospemifene (Compound) resembles Pentamidine (Compound)
Clofarabine (Compound) upregulates CDK7 (Gene) and CDK7 (Gene) is upregulated by Pentamidine (Compound)
Clofarabine (Compound) upregulates PNP (Gene) and PNP ... |
DB00074 | DB14409 | 1,309 | 1,129 | [
"DDInter166",
"DDInter867"
] | Basiliximab | Human adenovirus e serotype 4 strain cl-68578 antigen | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1309,
24,
1129
]
],
[
[
1309,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1309,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
1309,
63,
1184
],
[
11... | [
[
[
"Basiliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Basiliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Basiliximab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Basiliximab may cause a moderate interaction that could exacerbate diseases when ta... |
DB00357 | DB08895 | 1,051 | 976 | [
"DDInter71",
"DDInter1825"
] | Aminoglutethimide | Tofacitinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
1051,
24,
976
]
],
[
[
1051,
24,
307
],
[
307,
23,
976
]
],
[
[
1051,
24,
214
],
[
214,
63,
976
]
],
[
[
1051,
24,
723
],
[
723,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Tofacitinib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Fostamatin... |
DB00812 | DB12015 | 998 | 1,033 | [
"DDInter1451",
"DDInter53"
] | Phenylbutazone | Alpelisib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
998,
24,
1033
]
],
[
[
998,
24,
1135
],
[
1135,
23,
1033
]
],
[
[
998,
40,
576
],
[
576,
24,
1033
]
],
[
[
998,
24,
738
],
[
738,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Phenylbutazone (Compound) resembles Methadone (Compound) and Methadone may cause a moderate interaction that coul... |
DB01234 | DB15035 | 1,220 | 503 | [
"DDInter513",
"DDInter1959"
] | Dexamethasone | Zanubrutinib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
1220,
25,
503
]
],
[
[
1220,
24,
868
],
[
868,
24,
503
]
],
[
[
1220,
63,
1324
],
[
1324,
24,
503
]
],
[
[
1220,
25,
1362
],
[
1362,
... | [
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
"V... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Troglitazon... |
DB00294 | DB00673 | 1,336 | 723 | [
"DDInter701",
"DDInter112"
] | Etonogestrel | Aprepitant | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
1336,
24,
723
]
],
[
[
1336,
6,
8374
],
[
8374,
45,
723
]
],
[
[
1336,
21,
28847
],
[
28847,
60,
723
]
],
[
[
1336,
25,
1101
],
[
1101... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Etonogestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Etonogestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aprepitant (Compound)
Etonogestrel (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Aprepitant (Compound)
Etonogestrel may lead to a major life threatening interaction when taken with Bexarotene and Bexarot... |
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