drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01045 | DB01070 | 463 | 1,098 | [
"DDInter1590",
"DDInter558"
] | Rifampicin | Dihydrotachysterol | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
463,
24,
1098
]
],
[
[
463,
63,
386
],
[
386,
25,
1098
]
],
[
[
463,
24,
460
],
[
460,
63,
1098
]
],
[
[
463,
1,
690
],
[
690,
2... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium carbonat... |
DB00934 | DB06595 | 413 | 1,491 | [
"DDInter1124",
"DDInter1214"
] | Maprotiline | Midostaurin | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
413,
24,
1491
]
],
[
[
413,
62,
112
],
[
112,
23,
1491
]
],
[
[
413,
63,
888
],
[
888,
24,
1491
]
],
[
[
413,
24,
1342
],
[
1342,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Maprotiline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Maprotiline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Ta... |
DB00250 | DB00641 | 10 | 467 | [
"DDInter475",
"DDInter1675"
] | Dapsone | Simvastatin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
10,
24,
467
]
],
[
[
10,
6,
8374
],
[
8374,
45,
467
]
],
[
[
10,
21,
28810
],
[
28810,
60,
467
]
],
[
[
10,
24,
110
],
[
110,
63... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Dapsone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Dapsone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Simvastatin (Compound)
Dapsone (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Simvastatin (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Po... |
DB00945 | DB08918 | 1,479 | 41 | [
"DDInter20",
"DDInter1059"
] | Acetylsalicylic acid | Levomilnacipran | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
1479,
24,
41
]
],
[
[
1479,
24,
901
],
[
901,
40,
41
]
],
[
[
1479,
6,
10215
],
[
10215,
45,
41
]
],
[
[
1479,
21,
28757
],
[
28757,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mi... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Acetylsalicylic acid (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Levomilnacipran (Compound)
Acetylsalicylic acid (Compound) ... |
DB00835 | DB00986 | 100 | 1,192 | [
"DDInter245",
"DDInter834"
] | Brompheniramine | Glycopyrronium | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
100,
24,
1192
]
],
[
[
100,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
100,
63,
262
],
[
262,
24,
1192
]
],
[
[
100,
6,
2720
],
[
2720,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clidi... |
DB05316 | DB11113 | 749 | 657 | [
"DDInter1467",
"DDInter307"
] | Pimavanserin | Castor oil | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
749,
24,
657
]
],
[
[
749,
24,
927
],
[
927,
63,
657
]
],
[
[
749,
24,
1491
],
[
1491,
24,
657
]
],
[
[
749,
25,
985
],
[
985,
2... | [
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Pimavanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
... | Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Pimavanserin may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and... |
DB00404 | DB08899 | 523 | 129 | [
"DDInter54",
"DDInter649"
] | Alprazolam | Enzalutamide | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
523,
24,
129
]
],
[
[
523,
6,
8374
],
[
8374,
45,
129
]
],
[
[
523,
21,
28703
],
[
28703,
60,
129
]
],
[
[
523,
63,
608
],
[
608,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Alprazolam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Alprazolam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Alprazolam (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lid... |
DB01268 | DB15982 | 1,151 | 1,339 | [
"DDInter1731",
"DDInter193"
] | Sunitinib | Berotralstat | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
1151,
24,
1339
]
],
[
[
1151,
64,
1101
],
[
1101,
23,
1339
]
],
[
[
1151,
24,
283
],
[
283,
23,
1339
]
],
[
[
1151,
63,
1213
],
[
1213... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Sunitinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a ... |
DB00682 | DB00795 | 126 | 50 | [
"DDInter1951",
"DDInter1725"
] | Warfarin | Sulfasalazine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Major | 2 | [
[
[
126,
25,
50
]
],
[
[
126,
23,
712
],
[
712,
1,
50
]
],
[
[
126,
64,
161
],
[
161,
1,
50
]
],
[
[
126,
64,
682
],
[
682,
23,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Olsalazine"
],
[
"Olsalazine",
... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Olsalazine and Olsalazine (Compound) resembles Sulfasalazine (Compound)
Warfarin may lead to a major life threatening interaction when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasalazine (Compound)
Warfarin ma... |
DB00519 | DB00687 | 1,638 | 870 | [
"DDInter1843",
"DDInter747"
] | Trandolapril | Fludrocortisone | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
1638,
24,
870
]
],
[
[
1638,
24,
1220
],
[
1220,
40,
870
]
],
[
[
1638,
63,
251
],
[
251,
40,
870
]
],
[
[
1638,
21,
28835
],
[
28835,... | [
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Trandolapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Trandolapril may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles F... |
DB09054 | DB09330 | 384 | 985 | [
"DDInter905",
"DDInter1352"
] | Idelalisib | Osimertinib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
384,
25,
985
]
],
[
[
384,
63,
168
],
[
168,
23,
985
]
],
[
[
384,
64,
1478
],
[
1478,
24,
985
]
],
[
[
384,
63,
66
],
[
66,
24,... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bortezomi... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Idelalisib may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a m... |
DB00206 | DB01067 | 1,245 | 959 | [
"DDInter1582",
"DDInter826"
] | Reserpine | Glipizide | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1245,
24,
959
]
],
[
[
1245,
24,
245
],
[
245,
40,
959
]
],
[
[
1245,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1245,
18,
2114
],
[
2114,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB00685 | DB01156 | 1,299 | 593 | [
"DDInter1887",
"DDInter252"
] | Trovafloxacin | Bupropion | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
1299,
25,
593
]
],
[
[
1299,
21,
28757
],
[
28757,
60,
593
]
],
[
[
1299,
23,
1532
],
[
1532,
63,
593
]
],
[
[
1299,
64,
126
],
[
126,... | [
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Trovafloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspepsia"
],
[
"Dyspepsia",
"{u} (Side Effect) is caused by {v} ... | Trovafloxacin (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bupropion (Compound)
Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Bupr... |
DB00850 | DB11963 | 1,630 | 1,045 | [
"DDInter1432",
"DDInter465"
] | Perphenazine | Dacomitinib | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
1630,
24,
1045
]
],
[
[
1630,
1,
827
],
[
827,
24,
1045
]
],
[
[
1630,
24,
1376
],
[
1376,
24,
1045
]
],
[
[
1630,
35,
401
],
[
401,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Perphenazine",
"{u} (Compound) resembles {v} (Compound)",
"Trazodone"
],
[
"Trazodone",
"{u} may cause a mode... | Perphenazine (Compound) resembles Trazodone (Compound) and Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interacti... |
DB01041 | DB01224 | 770 | 623 | [
"DDInter1789",
"DDInter1553"
] | Thalidomide | Quetiapine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
770,
24,
623
]
],
[
[
770,
63,
827
],
[
827,
1,
623
]
],
[
[
770,
24,
851
],
[
851,
1,
623
]
],
[
[
770,
64,
695
],
[
695,
1,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Quetiapine (Compound)
... |
DB00656 | DB06595 | 827 | 1,491 | [
"DDInter1851",
"DDInter1214"
] | Trazodone | Midostaurin | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
827,
24,
1491
]
],
[
[
827,
23,
112
],
[
112,
23,
1491
]
],
[
[
827,
24,
888
],
[
888,
24,
1491
]
],
[
[
827,
24,
1017
],
[
1017,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Trazodone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Trazodone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxi... |
DB04951 | DB05812 | 187 | 1,374 | [
"DDInter1477",
"DDInter8"
] | Pirfenidone | Abiraterone | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
187,
24,
1374
]
],
[
[
187,
63,
441
],
[
441,
23,
1374
]
],
[
[
187,
63,
109
],
[
109,
24,
1374
]
],
[
[
187,
64,
529
],
[
529,
... | [
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Pirfenidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
],
... | Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Delavirdine and Delavirdine may cause a minor interaction that can limit clinical effects when taken with Abiraterone
Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Dul... |
DB00757 | DB00903 | 1,166 | 1,680 | [
"DDInter581",
"DDInter686"
] | Dolasetron | Etacrynic acid | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Major | 2 | [
[
[
1166,
25,
1680
]
],
[
[
1166,
21,
28882
],
[
28882,
60,
1680
]
],
[
[
1166,
25,
222
],
[
222,
63,
1680
]
],
[
[
1166,
24,
659
],
[
659... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etacrynic acid"
]
],
[
[
"Dolasetron",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased",
"{u... | Dolasetron (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Etacrynic acid (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate disease... |
DB00794 | DB01229 | 759 | 973 | [
"DDInter1521",
"DDInter1377"
] | Primidone | Paclitaxel | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
759,
24,
973
]
],
[
[
759,
24,
310
],
[
310,
63,
973
]
],
[
[
759,
6,
8374
],
[
8374,
45,
973
]
],
[
[
759,
18,
3741
],
[
3741,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Primidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Primidone (Compoun... |
DB01165 | DB09330 | 1,539 | 985 | [
"DDInter1325",
"DDInter1352"
] | Ofloxacin | Osimertinib | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1539,
25,
985
]
],
[
[
1539,
62,
112
],
[
112,
23,
985
]
],
[
[
1539,
62,
134
],
[
134,
24,
985
]
],
[
[
1539,
63,
480
],
[
480,
... | [
[
[
"Ofloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Ofloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Vinorelbine and Vinore... |
DB00679 | DB08871 | 684 | 36 | [
"DDInter1796",
"DDInter666"
] | Thioridazine | Eribulin | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
684,
25,
36
]
],
[
[
684,
64,
1424
],
[
1424,
24,
36
]
],
[
[
684,
36,
820
],
[
820,
24,
36
]
],
[
[
684,
40,
216
],
[
216,
24,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
],
[
"Quinine",
"{u} may c... | Thioridazine may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Thioridazine (Compound) resembles Alimemazine (Compound) and Thioridazine may lead to a major life threatening interaction when taken... |
DB01039 | DB01166 | 535 | 477 | [
"DDInter718",
"DDInter379"
] | Fenofibrate | Cilostazol | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
535,
24,
477
]
],
[
[
535,
6,
8374
],
[
8374,
45,
477
]
],
[
[
535,
21,
28919
],
[
28919,
60,
477
]
],
[
[
535,
64,
126
],
[
126,
... | [
[
[
"Fenofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Fenofibrate",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Fenofibrate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Fenofibrate (Compound) causes Arthritis (Side Effect) and Arthritis (Side Effect) is caused by Cilostazol (Compound)
Fenofibrate may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause... |
DB00241 | DB00910 | 288 | 1,041 | [
"DDInter257",
"DDInter1394"
] | Butalbital | Paricalcitol | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Moderate | 1 | [
[
[
288,
24,
1041
]
],
[
[
288,
63,
386
],
[
386,
25,
1041
]
],
[
[
288,
24,
1098
],
[
1098,
64,
1041
]
],
[
[
288,
24,
159
],
[
159,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paricalcitol"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
],
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Paricalcitol
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Dihydrotachysterol and D... |
DB01166 | DB01240 | 477 | 885 | [
"DDInter379",
"DDInter657"
] | Cilostazol | Epoprostenol | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
477,
24,
885
]
],
[
[
477,
63,
1061
],
[
1061,
1,
885
]
],
[
[
477,
10,
11573
],
[
11573,
49,
885
]
],
[
[
477,
21,
28684
],
[
28684,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Cilostazol (Compound) palliates systemic scleroderma (Disease) and systemic scleroderma (Disease) is palliated by Epoprostenol (Compound)
Cilostazol (Comp... |
DB00907 | DB01064 | 290 | 1,148 | [
"DDInter427",
"DDInter987"
] | Cocaine (topical) | Isoprenaline | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Major | 2 | [
[
[
290,
25,
1148
]
],
[
[
290,
64,
1636
],
[
1636,
24,
1148
]
],
[
[
290,
25,
480
],
[
480,
24,
1148
]
],
[
[
290,
25,
584
],
[
584,
... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylephrine"
],
[
"Phenylephrine",
"{u}... | Cocaine may lead to a major life threatening interaction when taken with Isoprenaline
Cocaine may lead to a major life threatening interaction when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Cocaine may lead to a major life thr... |
DB00372 | DB00674 | 999 | 1,516 | [
"DDInter1793",
"DDInter802"
] | Thiethylperazine | Galantamine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Moderate | 1 | [
[
[
999,
24,
1516
]
],
[
[
999,
63,
475
],
[
475,
40,
1516
]
],
[
[
999,
24,
828
],
[
828,
40,
1516
]
],
[
[
999,
24,
19
],
[
19,
24... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Galantamine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine (Compound) resembles Galantamine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Galantamine (Co... |
DB01132 | DB06791 | 1,130 | 1,446 | [
"DDInter1472",
"DDInter1021"
] | Pioglitazone | Lanreotide | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
1130,
24,
1446
]
],
[
[
1130,
24,
154
],
[
154,
63,
1446
]
],
[
[
1130,
24,
655
],
[
655,
24,
1446
]
],
[
[
1130,
63,
1324
],
[
1324,
... | [
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Pioglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
... | Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Et... |
DB01284 | DB11988 | 1,042 | 270 | [
"DDInter1782",
"DDInter1321"
] | Tetracosactide | Ocrelizumab | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1042,
24,
270
]
],
[
[
1042,
24,
713
],
[
713,
24,
270
]
],
[
[
1042,
24,
287
],
[
287,
63,
270
]
],
[
[
1042,
63,
66
],
[
66,
2... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00536 | DB00782 | 1,225 | 1,123 | [
"DDInter848",
"DDInter1535"
] | Guanidine | Propantheline | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
1225,
24,
1123
]
],
[
[
1225,
21,
28956
],
[
28956,
60,
1123
]
],
[
[
1225,
24,
1192
],
[
1192,
63,
1123
]
],
[
[
1225,
24,
1442
],
[
... | [
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Guanidine",
"{u} (Compound) causes {v} (Side Effect)",
"Palpitations"
],
[
"Palpitations",
"{u} (Side Effect) ... | Guanidine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Propantheline (Compound)
Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when tak... |
DB00285 | DB01001 | 1,100 | 688 | [
"DDInter1927",
"DDInter1632"
] | Venlafaxine | Salbutamol | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1100,
24,
688
]
],
[
[
1100,
24,
874
],
[
874,
24,
688
]
],
[
[
1100,
24,
1148
],
[
1148,
63,
688
]
],
[
[
1100,
6,
8374
],
[
8374,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
[... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and ... |
DB00470 | DB12332 | 530 | 1,619 | [
"DDInter601",
"DDInter1626"
] | Dronabinol | Rucaparib | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
530,
24,
1619
]
],
[
[
530,
24,
222
],
[
222,
23,
1619
]
],
[
[
530,
23,
307
],
[
307,
23,
1619
]
],
[
[
530,
63,
1407
],
[
1407,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Dronabinol may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil ... |
DB08932 | DB09122 | 1,398 | 1,613 | [
"DDInter1111",
"DDInter1409"
] | Macitentan | Peginterferon beta-1a | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1398,
24,
1613
]
],
[
[
1398,
63,
600
],
[
600,
24,
1613
]
],
[
[
1398,
24,
351
],
[
351,
63,
1613
]
],
[
[
1398,
64,
609
],
[
609,
... | [
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
... | Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Ribocicl... |
DB00889 | DB06176 | 1,133 | 1,342 | [
"DDInter840",
"DDInter1616"
] | Granisetron | Romidepsin | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1133,
24,
1342
]
],
[
[
1133,
23,
1247
],
[
1247,
23,
1342
]
],
[
[
1133,
24,
956
],
[
956,
24,
1342
]
],
[
[
1133,
63,
485
],
[
485,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Granisetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Granisetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin... |
DB00906 | DB04868 | 1,567 | 478 | [
"DDInter1801",
"DDInter1293"
] | Tiagabine | Nilotinib | Tiagabine is an anti-convulsive medication. It is also used in the treatment for panic disorder as are a few other anticonvulsants. Though the exact mechanism by which tiagabine exerts its effect on the human body is unknown, it does appear to operate as a selective GABA reuptake inhibitor. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1567,
24,
478
]
],
[
[
1567,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1567,
21,
28963
],
[
28963,
60,
478
]
],
[
[
1567,
24,
1040
],
[
1040... | [
[
[
"Tiagabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Tiagabine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tiagabine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Tiagabine (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Tiagabine may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib ma... |
DB00186 | DB04837 | 905 | 649 | [
"DDInter1092",
"DDInter407"
] | Lorazepam | Clofedanol | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
905,
24,
649
]
],
[
[
905,
24,
1376
],
[
1376,
24,
649
]
],
[
[
905,
40,
11275
],
[
11275,
40,
649
]
],
[
[
905,
24,
832
],
[
832,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Lorazepam may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Lorazepam (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Clof... |
DB00065 | DB00564 | 581 | 1,236 | [
"DDInter923",
"DDInter293"
] | Infliximab | Carbamazepine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
581,
24,
1236
]
],
[
[
581,
24,
362
],
[
362,
1,
1236
]
],
[
[
581,
25,
1101
],
[
1101,
23,
1236
]
],
[
[
581,
24,
608
],
[
608,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Carbamazepine (Compound)
Infliximab may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical eff... |
DB00193 | DB09272 | 534 | 412 | [
"DDInter1841",
"DDInter632"
] | Tramadol | Eluxadoline | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
534,
24,
412
]
],
[
[
534,
24,
1594
],
[
1594,
24,
412
]
],
[
[
534,
25,
475
],
[
475,
24,
412
]
],
[
[
534,
25,
407
],
[
407,
6... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Tramadol may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moder... |
DB09291 | DB11967 | 741 | 710 | [
"DDInter1615",
"DDInter210"
] | Rolapitant | Binimetinib | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
741,
24,
710
]
],
[
[
741,
63,
1237
],
[
1237,
24,
710
]
],
[
[
741,
24,
733
],
[
733,
63,
710
]
],
[
[
741,
64,
129
],
[
129,
2... | [
[
[
"Rolapitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Rolapitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[... | Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Eslicarbazepine ... |
DB01082 | DB14006 | 1,448 | 972 | [
"DDInter1713",
"DDInter370"
] | Streptomycin | Choline salicylate | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1448,
24,
972
]
],
[
[
1448,
63,
660
],
[
660,
23,
972
]
],
[
[
1448,
24,
379
],
[
379,
23,
972
]
],
[
[
1448,
63,
1132
],
[
1132,
... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Rabepra... |
DB08827 | DB11837 | 990 | 1,297 | [
"DDInter1085",
"DDInter1351"
] | Lomitapide | Osilodrostat | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
990,
24,
1297
]
],
[
[
990,
23,
1135
],
[
1135,
23,
1297
]
],
[
[
990,
25,
1320
],
[
1320,
63,
1297
]
],
[
[
990,
63,
578
],
[
578,
... | [
[
[
"Lomitapide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Lomitapide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Lomitapide may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Lomitapide may lead to a major life threatening interaction when taken with Elagolix and Elagolix may cause a modera... |
DB02546 | DB09564 | 137 | 1,296 | [
"DDInter1947",
"DDInter930"
] | Vorinostat | Insulin degludec | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
137,
24,
1296
]
],
[
[
137,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
137,
24,
761
],
[
761,
24,
1296
]
],
[
[
137,
24,
1385
],
[
1385,
... | [
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Vorinostat may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Vorinostat may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin a... |
DB00757 | DB01041 | 1,166 | 770 | [
"DDInter581",
"DDInter1789"
] | Dolasetron | Thalidomide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1166,
24,
770
]
],
[
[
1166,
6,
6017
],
[
6017,
45,
770
]
],
[
[
1166,
21,
29425
],
[
29425,
60,
770
]
],
[
[
1166,
25,
609
],
[
609,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)"... | Dolasetron (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Thalidomide (Compound)
Dolasetron (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Thalidomide (Compound)
Dolasetron may lead to a major life threatening interaction when taken with Clarithrom... |
DB00009 | DB00790 | 1,271 | 664 | [
"DDInter56",
"DDInter1431"
] | Alteplase | Perindopril | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Moderate | 1 | [
[
[
1271,
24,
664
]
],
[
[
1271,
24,
1638
],
[
1638,
1,
664
]
],
[
[
1271,
24,
954
],
[
954,
40,
664
]
],
[
[
1271,
24,
885
],
[
885,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindopril"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Perindopril (Compound... |
DB00491 | DB09381 | 127 | 192 | [
"DDInter1217",
"DDInter678"
] | Miglitol | Esterified estrogens | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
127,
24,
192
]
],
[
[
127,
24,
1019
],
[
1019,
63,
192
]
],
[
[
127,
63,
1685
],
[
1685,
24,
192
]
],
[
[
127,
24,
1040
],
[
1040,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
],
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort and Deflazacort may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Insulin human... |
DB01211 | DB11718 | 609 | 927 | [
"DDInter393",
"DDInter640"
] | Clarithromycin | Encorafenib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Major | 2 | [
[
[
609,
25,
927
]
],
[
[
609,
62,
112
],
[
112,
23,
927
]
],
[
[
609,
24,
720
],
[
720,
24,
927
]
],
[
[
609,
63,
216
],
[
216,
24,... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Encorafenib"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Mineral oi... |
DB00285 | DB01088 | 1,100 | 714 | [
"DDInter1927",
"DDInter908"
] | Venlafaxine | Iloprost | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1100,
24,
714
]
],
[
[
1100,
24,
1479
],
[
1479,
24,
714
]
],
[
[
1100,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1100,
24,
1564
],
[
1564,... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with A... |
DB00554 | DB00927 | 1,027 | 1,559 | [
"DDInter1478",
"DDInter712"
] | Piroxicam | Famotidine | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Minor | 0 | [
[
[
1027,
23,
1559
]
],
[
[
1027,
6,
16560
],
[
16560,
45,
1559
]
],
[
[
1027,
24,
1274
],
[
1274,
23,
1559
]
],
[
[
1027,
25,
1468
],
[
1... | [
[
[
"Piroxicam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Famotidine"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"SLC22A8"
],
[
"SLC22A8",
"{u} (Gene) is bound by {v} (Compound)",
... | Piroxicam (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Famotidine (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Famotidine
Piroxicam may le... |
DB00331 | DB01403 | 1,645 | 9 | [
"DDInter1164",
"DDInter1175"
] | Metformin | Methotrimeprazine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1645,
24,
9
]
],
[
[
1645,
24,
1178
],
[
1178,
40,
9
]
],
[
[
1645,
24,
401
],
[
401,
24,
9
]
],
[
[
1645,
24,
1630
],
[
1630,
1... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate int... |
DB09073 | DB12457 | 951 | 1,180 | [
"DDInter1379",
"DDInter1598"
] | Palbociclib | Rimegepant | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
951,
24,
1180
]
],
[
[
951,
24,
1619
],
[
1619,
24,
1180
]
],
[
[
951,
63,
1419
],
[
1419,
24,
1180
]
],
[
[
951,
24,
283
],
[
283,
... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib... |
DB00307 | DB00860 | 1,101 | 891 | [
"DDInter202",
"DDInter1513"
] | Bexarotene | Prednisolone | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
1101,
24,
891
]
],
[
[
1101,
24,
989
],
[
989,
1,
891
]
],
[
[
1101,
24,
175
],
[
175,
40,
891
]
],
[
[
1101,
5,
11555
],
[
11555,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
],
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Prednisolone (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolo... |
DB01097 | DB09073 | 1,377 | 951 | [
"DDInter1033",
"DDInter1379"
] | Leflunomide | Palbociclib | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
1377,
25,
951
]
],
[
[
1377,
24,
496
],
[
496,
63,
951
]
],
[
[
1377,
25,
1476
],
[
1476,
63,
951
]
],
[
[
1377,
25,
259
],
[
259,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
[
... | Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Leflunomide may lead to a major life threatening interaction when taken with Brigatinib and ... |
DB09570 | DB11901 | 1,480 | 913 | [
"DDInter1002",
"DDInter107"
] | Ixazomib | Apalutamide | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1480,
25,
913
]
],
[
[
1480,
63,
112
],
[
112,
23,
913
]
],
[
[
1480,
24,
110
],
[
110,
62,
913
]
],
[
[
1480,
63,
671
],
[
671,
... | [
[
[
"Ixazomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin ... |
DB01394 | DB11979 | 1,554 | 1,320 | [
"DDInter431",
"DDInter625"
] | Colchicine | Elagolix | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1554,
24,
1320
]
],
[
[
1554,
63,
168
],
[
168,
23,
1320
]
],
[
[
1554,
64,
79
],
[
79,
24,
1320
]
],
[
[
1554,
24,
129
],
[
129,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Colchicine may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cause a mode... |
DB08820 | DB11979 | 1,478 | 1,320 | [
"DDInter997",
"DDInter625"
] | Ivacaftor | Elagolix | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1478,
24,
1320
]
],
[
[
1478,
63,
608
],
[
608,
23,
1320
]
],
[
[
1478,
23,
271
],
[
271,
23,
1320
]
],
[
[
1478,
24,
1297
],
[
1297,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Elagolix
Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may c... |
DB00196 | DB08886 | 600 | 637 | [
"DDInter743",
"DDInter126"
] | Fluconazole | Asparaginase Erwinia chrysanthemi | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
600,
24,
637
]
],
[
[
600,
24,
392
],
[
392,
24,
637
]
],
[
[
600,
25,
467
],
[
467,
24,
637
]
],
[
[
600,
24,
159
],
[
159,
63,... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"La... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Fluconazole may lead to a major life threatening interaction when taken with Simvastatin a... |
DB00867 | DB01410 | 1,052 | 423 | [
"DDInter1606",
"DDInter375"
] | Ritodrine | Ciclesonide | Adrenergic beta-agonist used to control premature labor. | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Minor | 0 | [
[
[
1052,
23,
423
]
],
[
[
1052,
62,
1573
],
[
1573,
1,
423
]
],
[
[
1052,
62,
1351
],
[
1351,
40,
423
]
],
[
[
1052,
23,
1486
],
[
1486,
... | [
[
[
"Ritodrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ciclesonide"
]
],
[
[
"Ritodrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisone"
],
[
"... | Ritodrine may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Ritodrine may cause a minor interaction that can limit clinical effects when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Compound)
Ri... |
DB01234 | DB14006 | 1,220 | 972 | [
"DDInter513",
"DDInter370"
] | Dexamethasone | Choline salicylate | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1220,
24,
972
]
],
[
[
1220,
23,
771
],
[
771,
62,
972
]
],
[
[
1220,
40,
1573
],
[
1573,
24,
972
]
],
[
[
1220,
63,
176
],
[
176,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Dexamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
... | Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Dexamethasone (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate intera... |
DB06595 | DB14443 | 1,491 | 987 | [
"DDInter1214",
"DDInter1931"
] | Midostaurin | Vibrio cholerae CVD 103-HgR strain live antigen | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1491,
24,
987
]
],
[
[
1491,
63,
1220
],
[
1220,
24,
987
]
],
[
[
1491,
24,
351
],
[
351,
24,
987
]
],
[
[
1491,
25,
384
],
[
384,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Midostaurin may cause a moderate interaction that could exacerbate d... |
DB00289 | DB11901 | 847 | 913 | [
"DDInter132",
"DDInter107"
] | Atomoxetine | Apalutamide | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
847,
24,
913
]
],
[
[
847,
23,
112
],
[
112,
23,
913
]
],
[
[
847,
63,
600
],
[
600,
24,
913
]
],
[
[
847,
24,
28
],
[
28,
24,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Atomoxetine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Atomoxetine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Atomoxetine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and ... |
DB01005 | DB06643 | 995 | 1,136 | [
"DDInter894",
"DDInter500"
] | Hydroxyurea | Denosumab | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
995,
24,
1136
]
],
[
[
995,
63,
1555
],
[
1555,
24,
1136
]
],
[
[
995,
24,
1532
],
[
1532,
24,
1136
]
],
[
[
995,
25,
1377
],
[
1377,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
[
... | Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifo... |
DB01076 | DB01229 | 700 | 973 | [
"DDInter133",
"DDInter1377"
] | Atorvastatin | Paclitaxel | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
700,
24,
973
]
],
[
[
700,
24,
310
],
[
310,
63,
973
]
],
[
[
700,
6,
7524
],
[
7524,
45,
973
]
],
[
[
700,
7,
2903
],
[
2903,
4... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Atorvastatin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Paclitaxel (Compound)
Atorvastatin... |
DB01121 | DB01233 | 94 | 1,311 | [
"DDInter1437",
"DDInter1197"
] | Phenacemide | Metoclopramide | Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
94,
24,
1311
]
],
[
[
94,
63,
1010
],
[
1010,
23,
1311
]
],
[
[
94,
63,
662
],
[
662,
24,
1311
]
],
[
[
94,
24,
1264
],
[
1264,
... | [
[
[
"Phenacemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Phenacemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
],
... | Phenacemide may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metoclopramide
Phenacemide may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and... |
DB00816 | DB01579 | 1,674 | 341 | [
"DDInter1346",
"DDInter1439"
] | Orciprenaline | Phendimetrazine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Moderate | 1 | [
[
[
1674,
24,
341
]
],
[
[
1674,
21,
28662
],
[
28662,
60,
341
]
],
[
[
1674,
24,
959
],
[
959,
24,
341
]
],
[
[
1674,
24,
1281
],
[
1281,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Orciprenaline",
"{u} (Compound) causes {v} (Side Effect)",
"Tremor"
],
[
"Tremor",
"{u} (Side Effect) is... | Orciprenaline (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Phendimetrazine (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Phen... |
DB00434 | DB00532 | 13 | 208 | [
"DDInter459",
"DDInter1152"
] | Cyproheptadine | Mephenytoin | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Moderate | 1 | [
[
[
13,
24,
208
]
],
[
[
13,
63,
1242
],
[
1242,
24,
208
]
],
[
[
13,
24,
1219
],
[
1219,
63,
208
]
],
[
[
13,
24,
530
],
[
530,
24,... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mephenytoin"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Mephenytoin
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine an... |
DB00099 | DB12332 | 440 | 1,619 | [
"DDInter735",
"DDInter1626"
] | Filgrastim | Rucaparib | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
440,
24,
1619
]
],
[
[
440,
24,
309
],
[
309,
24,
1619
]
],
[
[
440,
63,
599
],
[
599,
24,
1619
]
],
[
[
440,
24,
503
],
[
503,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alem... |
DB00379 | DB09268 | 143 | 1,662 | [
"DDInter1206",
"DDInter1464"
] | Mexiletine | Picosulfuric acid | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
143,
24,
1662
]
],
[
[
143,
63,
1010
],
[
1010,
24,
1662
]
],
[
[
143,
64,
1031
],
[
1031,
24,
1662
]
],
[
[
143,
24,
1374
],
[
1374,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
],
... | Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Mexiletine may lead to a major life threatening interaction when taken with Theophylline and Theophylline... |
DB00762 | DB00877 | 613 | 629 | [
"DDInter973",
"DDInter1678"
] | Irinotecan | Sirolimus | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
613,
24,
629
]
],
[
[
613,
6,
4973
],
[
4973,
45,
629
]
],
[
[
613,
7,
9489
],
[
9489,
46,
629
]
],
[
[
613,
18,
1748
],
[
1748,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Irinotecan",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Irinotecan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Irinotecan (Compound) upregulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Sirolimus (Compound)
Irinotecan (Compound) downregulates IGF1R (Gene) and IGF1R (Gene) is upregulated by Sirolimus (Compound)
Irinotecan (Compound) d... |
DB00496 | DB01069 | 194 | 401 | [
"DDInter480",
"DDInter1533"
] | Darifenacin | Promethazine | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
194,
24,
401
]
],
[
[
194,
24,
1264
],
[
1264,
63,
401
]
],
[
[
194,
24,
104
],
[
104,
24,
401
]
],
[
[
194,
6,
4304
],
[
4304,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdi... |
DB01181 | DB06688 | 1,532 | 1,430 | [
"DDInter906",
"DDInter1677"
] | Ifosfamide | Sipuleucel-T | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
1532,
24,
1430
]
],
[
[
1532,
63,
51
],
[
51,
24,
1430
]
],
[
[
1532,
25,
676
],
[
676,
63,
1430
]
],
[
[
1532,
24,
1531
],
[
1531,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Ifosfamide may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib ... |
DB12001 | DB14409 | 564 | 1,129 | [
"DDInter7",
"DDInter867"
] | Abemaciclib | Human adenovirus e serotype 4 strain cl-68578 antigen | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
564,
24,
1129
]
],
[
[
564,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
564,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
564,
24,
1476
],
[
1476,
... | [
[
[
"Abemaciclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Abemaciclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Abemaciclib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Abemaciclib may cause a moderate interaction that could exacerbate diseases when ta... |
DB01069 | DB01362 | 401 | 497 | [
"DDInter1533",
"DDInter960"
] | Promethazine | Iohexol | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
401,
25,
497
]
],
[
[
401,
21,
28787
],
[
28787,
60,
497
]
],
[
[
401,
63,
323
],
[
323,
24,
497
]
],
[
[
401,
24,
772
],
[
772,
... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Promethazine",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (C... | Promethazine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iohexol (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases wh... |
DB00734 | DB06663 | 1,664 | 1,154 | [
"DDInter1605",
"DDInter1398"
] | Risperidone | Pasireotide | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
1664,
25,
1154
]
],
[
[
1664,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1664,
23,
112
],
[
112,
23,
1154
]
],
[
[
1664,
24,
1385
],
[
13... | [
[
[
"Risperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Risperidone",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused... | Risperidone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Risperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when tak... |
DB01166 | DB01182 | 477 | 371 | [
"DDInter379",
"DDInter1534"
] | Cilostazol | Propafenone | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
477,
24,
371
]
],
[
[
477,
63,
847
],
[
847,
1,
371
]
],
[
[
477,
63,
675
],
[
675,
40,
371
]
],
[
[
477,
63,
455
],
[
455,
24,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
[
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Pro... |
DB00708 | DB00782 | 1,454 | 1,123 | [
"DDInter1718",
"DDInter1535"
] | Sufentanil | Propantheline | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
1454,
24,
1123
]
],
[
[
1454,
21,
28681
],
[
28681,
60,
1123
]
],
[
[
1454,
24,
537
],
[
537,
63,
1123
]
],
[
[
1454,
1,
411
],
[
411,... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Sufentanil",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Sid... | Sufentanil (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Propantheline (Compound)
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when tak... |
DB08827 | DB08912 | 990 | 1,040 | [
"DDInter1085",
"DDInter462"
] | Lomitapide | Dabrafenib | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
990,
24,
1040
]
],
[
[
990,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
990,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
990,
64,
168
],
[
168,
... | [
[
[
"Lomitapide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Lomitapide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Lomitapide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Lomitapide (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Lomitapide may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib ... |
DB00773 | DB01005 | 896 | 995 | [
"DDInter702",
"DDInter894"
] | Etoposide | Hydroxyurea | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
896,
24,
995
]
],
[
[
896,
5,
11555
],
[
11555,
44,
995
]
],
[
[
896,
21,
29429
],
[
29429,
60,
995
]
],
[
[
896,
62,
1299
],
[
1299,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Etoposide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Etoposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Hydroxyurea (Compound)
Etoposide (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Hydroxyurea (Compound)
Etoposide may cause a minor interaction that can limit clinical e... |
DB01136 | DB06589 | 772 | 1,250 | [
"DDInter305",
"DDInter1400"
] | Carvedilol | Pazopanib | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
772,
25,
1250
]
],
[
[
772,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
772,
6,
3191
],
[
3191,
57,
1250
]
],
[
[
772,
21,
29203
],
[
29203,
... | [
[
[
"Carvedilol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Carvedilol",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Pazopani... | Carvedilol (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Carvedilol (Compound) binds VEGFA (Gene) and VEGFA (Gene) is downregulated by Pazopanib (Compound)
Carvedilol (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side E... |
DB06589 | DB11003 | 1,250 | 748 | [
"DDInter1400",
"DDInter100"
] | Pazopanib | Anthrax vaccine | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1250,
24,
748
]
],
[
[
1250,
63,
322
],
[
322,
24,
748
]
],
[
[
1250,
24,
594
],
[
594,
24,
748
]
],
[
[
1250,
25,
676
],
[
676,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosu... |
DB00916 | DB01069 | 112 | 401 | [
"DDInter1202",
"DDInter1533"
] | Metronidazole | Promethazine | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Minor | 0 | [
[
[
112,
23,
401
]
],
[
[
112,
23,
1264
],
[
1264,
63,
401
]
],
[
[
112,
63,
1236
],
[
1236,
24,
401
]
],
[
[
112,
6,
6017
],
[
6017,
... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Promethazine"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doxepin"
],
[
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Car... |
DB01240 | DB01381 | 885 | 958 | [
"DDInter657",
"DDInter819"
] | Epoprostenol | Ginkgo biloba | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
885,
24,
958
]
],
[
[
885,
63,
1347
],
[
1347,
24,
958
]
],
[
[
885,
25,
792
],
[
792,
63,
958
]
],
[
[
885,
24,
840
],
[
840,
6... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
... | Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Epoprostenol may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban... |
DB00551 | DB04865 | 1,660 | 4 | [
"DDInter17",
"DDInter1335"
] | Acetohydroxamic acid | Omacetaxine mepesuccinate | Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1660,
24,
4
]
],
[
[
1660,
40,
995
],
[
995,
24,
4
]
],
[
[
1660,
24,
1683
],
[
1683,
63,
4
]
],
[
[
1660,
63,
599
],
[
599,
24,... | [
[
[
"Acetohydroxamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Acetohydroxamic acid",
"{u} (Compound) resembles {v} (Compound)",
"Hydroxyurea"
],
[
"Hydroxy... | Acetohydroxamic acid (Compound) resembles Hydroxyurea (Compound) and Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Acetohydroxamic acid may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may ... |
DB08865 | DB11901 | 1,593 | 913 | [
"DDInter448",
"DDInter107"
] | Crizotinib | Apalutamide | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1593,
25,
913
]
],
[
[
1593,
64,
312
],
[
312,
23,
913
]
],
[
[
1593,
63,
112
],
[
112,
23,
913
]
],
[
[
1593,
23,
271
],
[
271,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eplerenone"
],
[
"Eplerenone",
"{u} ... | Crizotinib may lead to a major life threatening interaction when taken with Eplerenone and Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may c... |
DB00204 | DB11110 | 228 | 603 | [
"DDInter580",
"DDInter1115"
] | Dofetilide | Magnesium citrate | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
228,
24,
603
]
],
[
[
228,
25,
57
],
[
57,
24,
603
]
],
[
[
228,
25,
484
],
[
484,
63,
603
]
],
[
[
228,
23,
891
],
[
891,
24,
... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Dofetilide may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Dofetilide may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may ... |
DB06688 | DB14762 | 1,430 | 994 | [
"DDInter1677",
"DDInter1602"
] | Sipuleucel-T | Risankizumab | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Moderate | 1 | [
[
[
1430,
24,
994
]
],
[
[
1430,
63,
4
],
[
4,
24,
994
]
],
[
[
1430,
24,
270
],
[
270,
24,
994
]
],
[
[
1430,
24,
287
],
[
287,
63,... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risankizumab"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucci... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Risankizumab
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases w... |
DB00697 | DB01240 | 876 | 885 | [
"DDInter1821",
"DDInter657"
] | Tizanidine | Epoprostenol | Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury. It may also be caused by musculoskeletal injury. Regardless of the cause, muscle spasticity can be an extremely painful and debili... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Major | 2 | [
[
[
876,
25,
885
]
],
[
[
876,
64,
1061
],
[
1061,
1,
885
]
],
[
[
876,
21,
28936
],
[
28936,
60,
885
]
],
[
[
876,
64,
1018
],
[
1018,
... | [
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
]
],
[
[
"Tizanidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Treprostinil"
],
[
"Treprostinil",
... | Tizanidine may lead to a major life threatening interaction when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Tizanidine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Epoprostenol (Compound)
Tizanidine may lead to a major life threate... |
DB00986 | DB01069 | 1,192 | 401 | [
"DDInter834",
"DDInter1533"
] | Glycopyrronium | Promethazine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1192,
24,
401
]
],
[
[
1192,
63,
146
],
[
146,
24,
401
]
],
[
[
1192,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1192,
6,
4304
],
[
4304,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Doxepin... |
DB00619 | DB11791 | 1,419 | 785 | [
"DDInter909",
"DDInter287"
] | Imatinib | Capmatinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
1419,
24,
785
]
],
[
[
1419,
63,
1215
],
[
1215,
23,
785
]
],
[
[
1419,
24,
101
],
[
101,
23,
785
]
],
[
[
1419,
25,
1135
],
[
1135,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Capmatinib
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazole and Dex... |
DB01176 | DB06016 | 537 | 1,508 | [
"DDInter453",
"DDInter300"
] | Cyclizine | Cariprazine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
537,
24,
1508
]
],
[
[
537,
63,
1242
],
[
1242,
24,
1508
]
],
[
[
537,
24,
849
],
[
849,
63,
1508
]
],
[
[
537,
74,
1376
],
[
1376,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],
[
... | Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyram... |
DB00056 | DB10343 | 816 | 962 | [
"DDInter814",
"DDInter160"
] | Gemtuzumab ozogamicin | Bacillus calmette-guerin substrain tice live antigen | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
816,
25,
962
]
],
[
[
816,
64,
1057
],
[
1057,
25,
962
]
],
[
[
816,
24,
270
],
[
270,
64,
962
]
],
[
[
816,
24,
663
],
[
663,
2... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Gemtuzumab ozogamicin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases whe... |
DB00690 | DB01233 | 1,216 | 1,311 | [
"DDInter762",
"DDInter1197"
] | Flurazepam | Metoclopramide | A benzodiazepine derivative used mainly as a hypnotic. | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Moderate | 1 | [
[
[
1216,
24,
1311
]
],
[
[
1216,
21,
28691
],
[
28691,
60,
1311
]
],
[
[
1216,
24,
629
],
[
629,
24,
1311
]
],
[
[
1216,
24,
649
],
[
649... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
]
],
[
[
"Flurazepam",
"{u} (Compound) causes {v} (Side Effect)",
"Somnolence"
],
[
"Somnolence",
"{u} (Side Effect) i... | Flurazepam (Compound) causes Somnolence (Side Effect) and Somnolence (Side Effect) is caused by Metoclopramide (Compound)
Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Met... |
DB00835 | DB01192 | 100 | 560 | [
"DDInter245",
"DDInter1372"
] | Brompheniramine | Oxymorphone | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
100,
24,
560
]
],
[
[
100,
63,
828
],
[
828,
1,
560
]
],
[
[
100,
24,
314
],
[
314,
1,
560
]
],
[
[
100,
6,
12523
],
[
12523,
45... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
]... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxymorphone (... |
DB01089 | DB06704 | 1,340 | 247 | [
"DDInter502",
"DDInter952"
] | Deserpidine | Iobenguane (I-131) | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
1340,
37,
247
]
],
[
[
1340,
24,
1090
],
[
1090,
64,
247
]
],
[
[
1340,
1,
425
],
[
425,
25,
247
]
],
[
[
1340,
63,
1445
],
[
1445,
... | [
[
[
"Deserpidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Deserpidine",
"{u} may cause a moderate interaction that cou... | Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Deserpidine may lead to a major life threatening interaction when taken with Iobenguane
Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline and Tetryzoline may l... |
DB00468 | DB00834 | 1,424 | 932 | [
"DDInter1557",
"DDInter1215"
] | Quinine | Mifepristone | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
1424,
25,
932
]
],
[
[
1424,
6,
7524
],
[
7524,
45,
932
]
],
[
[
1424,
21,
28762
],
[
28762,
60,
932
]
],
[
[
1424,
63,
1101
],
[
1101... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Quinine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Mifepriston... | Quinine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Mifepristone (Compound)
Quinine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene ... |
DB00321 | DB00927 | 21 | 1,559 | [
"DDInter78",
"DDInter712"
] | Amitriptyline | Famotidine | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
21,
24,
1559
]
],
[
[
21,
6,
10215
],
[
10215,
45,
1559
]
],
[
[
21,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
21,
23,
112
],
[
112,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Com... | Amitriptyline (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Famotidine (Compound)
Amitriptyline (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Amitriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazol... |
DB00436 | DB09045 | 323 | 52 | [
"DDInter179",
"DDInter607"
] | Bendroflumethiazide | Dulaglutide | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
323,
24,
52
]
],
[
[
323,
24,
170
],
[
170,
23,
52
]
],
[
[
323,
40,
178
],
[
178,
24,
52
]
],
[
[
323,
24,
870
],
[
870,
24,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitaglip... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Bendroflumethiazide (Compound) resembles Polythiazide (Compound) and Polythiazide may cause a moderate... |
DB01042 | DB10429 | 1,307 | 200 | [
"DDInter1144",
"DDInter282"
] | Melphalan | Candida albicans | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
1307,
24,
200
]
],
[
[
1307,
24,
1683
],
[
1683,
24,
200
]
],
[
[
1307,
25,
976
],
[
976,
24,
200
]
],
[
[
1307,
62,
168
],
[
168,
... | [
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Melphalan may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00313 | DB00501 | 556 | 752 | [
"DDInter1913",
"DDInter380"
] | Valproic acid | Cimetidine | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
556,
23,
752
]
],
[
[
556,
6,
7950
],
[
7950,
45,
752
]
],
[
[
556,
21,
29134
],
[
29134,
60,
752
]
],
[
[
556,
23,
1384
],
[
1384,
... | [
[
[
"Valproic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Valproic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compoun... | Valproic acid (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cimetidine (Compound)
Valproic acid (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Valproic acid may cause a minor interaction that can limit clinical effects when taken with Magaldrate... |
DB00986 | DB09076 | 1,192 | 1,116 | [
"DDInter834",
"DDInter1899"
] | Glycopyrronium | Umeclidinium | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1192,
24,
1116
]
],
[
[
1192,
24,
849
],
[
849,
24,
1116
]
],
[
[
1192,
63,
1300
],
[
1300,
24,
1116
]
],
[
[
1192,
74,
352
],
[
352,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Haloperidol... |
DB00445 | DB01175 | 322 | 318 | [
"DDInter655",
"DDInter672"
] | Epirubicin | Escitalopram | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Major | 2 | [
[
[
322,
25,
318
]
],
[
[
322,
64,
1230
],
[
1230,
1,
318
]
],
[
[
322,
18,
8587
],
[
8587,
46,
318
]
],
[
[
322,
18,
3741
],
[
3741,
... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
],
[
"Citalopram",
"{u}... | Epirubicin may lead to a major life threatening interaction when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Epirubicin (Compound) downregulates RRS1 (Gene) and RRS1 (Gene) is upregulated by Escitalopram (Compound)
Epirubicin (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) i... |
DB01067 | DB01208 | 959 | 945 | [
"DDInter826",
"DDInter1705"
] | Glipizide | Sparfloxacin | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
959,
25,
945
]
],
[
[
959,
64,
739
],
[
739,
1,
945
]
],
[
[
959,
25,
1539
],
[
1539,
1,
945
]
],
[
[
959,
18,
3833
],
[
3833,
5... | [
[
[
"Glipizide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Glipizide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{... | Glipizide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Glipizide may lead to a major life threatening interaction when taken with Ofloxacin and Ofloxacin (Compound) resembles Sparfloxacin (Compound)
Glipizide (Compound) downr... |
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