drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00408 | DB01362 | 1,408 | 497 | [
"DDInter1099",
"DDInter960"
] | Loxapine | Iohexol | An antipsychotic agent used in schizophrenia. [PubChem] | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1408,
25,
497
]
],
[
[
1408,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1408,
63,
999
],
[
999,
25,
497
]
],
[
[
1408,
1,
87
],
[
87,
... | [
[
[
"Loxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Loxapine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) is caused by {v... | Loxapine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when taken with Ioh... |
DB00414 | DB01285 | 590 | 708 | [
"DDInter16",
"DDInter445"
] | Acetohexamide | Corticotropin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
590,
24,
708
]
],
[
[
590,
24,
1674
],
[
1674,
23,
708
]
],
[
[
590,
24,
170
],
[
170,
24,
708
]
],
[
[
590,
63,
88
],
[
88,
24,... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Sitaglip... |
DB00108 | DB01181 | 1,066 | 1,532 | [
"DDInter1268",
"DDInter906"
] | Natalizumab | Ifosfamide | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Major | 2 | [
[
[
1066,
25,
1532
]
],
[
[
1066,
64,
1648
],
[
1648,
24,
1532
]
],
[
[
1066,
25,
1330
],
[
1330,
63,
1532
]
],
[
[
1066,
25,
0
],
[
0,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ifosfamide"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aldesleukin"
],
[
"Aldesleukin",
"{... | Natalizumab may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Natalizumab may lead to a major life threatening interaction when taken with Naxitamab and Naxitamab may cause a moderate in... |
DB01764 | DB06595 | 805 | 1,491 | [
"DDInter469",
"DDInter1214"
] | Dalfopristin | Midostaurin | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
805,
24,
1491
]
],
[
[
805,
25,
1135
],
[
1135,
62,
1491
]
],
[
[
805,
24,
761
],
[
761,
24,
1491
]
],
[
[
805,
64,
888
],
[
888,
... | [
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Dalfopristin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxe... | Dalfopristin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Dalfopristin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cau... |
DB00396 | DB12267 | 989 | 1,476 | [
"DDInter1529",
"DDInter233"
] | Progesterone | Brigatinib | Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss. Progesterone is used in var... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
989,
24,
1476
]
],
[
[
989,
24,
629
],
[
629,
24,
1476
]
],
[
[
989,
63,
176
],
[
176,
24,
1476
]
],
[
[
989,
25,
1456
],
[
1456,
... | [
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Progesterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[... | Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Progesterone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine an... |
DB00595 | DB09473 | 1,545 | 884 | [
"DDInter1374",
"DDInter918"
] | Oxytetracycline | Indium In-111 oxyquinoline | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
1545,
24,
884
]
],
[
[
1545,
40,
1572
],
[
1572,
24,
884
]
],
[
[
1545,
24,
319
],
[
319,
24,
884
]
],
[
[
1545,
40,
1572
],
[
1572,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Oxytetracycline",
"{u} (Compound) resembles {v} (Compound)",
"Demeclocycline"
],
[
"Demeclocyclin... | Oxytetracycline (Compound) resembles Demeclocycline (Compound) and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Amoxicillin and Amoxicillin may cau... |
DB00241 | DB04837 | 288 | 649 | [
"DDInter257",
"DDInter407"
] | Butalbital | Clofedanol | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
288,
24,
649
]
],
[
[
288,
24,
1376
],
[
1376,
24,
649
]
],
[
[
288,
24,
832
],
[
832,
40,
649
]
],
[
[
288,
24,
11
],
[
11,
1,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Tripelennam... |
DB08908 | DB11817 | 713 | 1,259 | [
"DDInter564",
"DDInter165"
] | Dimethyl fumarate | Baricitinib | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
713,
25,
1259
]
],
[
[
713,
24,
949
],
[
949,
24,
1259
]
],
[
[
713,
24,
1129
],
[
1129,
63,
1259
]
],
[
[
713,
63,
1136
],
[
1136,
... | [
[
[
"Dimethyl fumarate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Dimethyl fumarate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid a... | Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Dime... |
DB00741 | DB00983 | 167 | 480 | [
"DDInter885",
"DDInter776"
] | Hydrocortisone | Formoterol | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Minor | 0 | [
[
[
167,
23,
480
]
],
[
[
167,
23,
1148
],
[
1148,
63,
480
]
],
[
[
167,
63,
1523
],
[
1523,
25,
480
]
],
[
[
167,
5,
11649
],
[
11649,
... | [
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Formoterol"
]
],
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Isoprenaline"
],
... | Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol a... |
DB00445 | DB00446 | 322 | 597 | [
"DDInter655",
"DDInter351"
] | Epirubicin | Chloramphenicol | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Moderate | 1 | [
[
[
322,
24,
597
]
],
[
[
322,
7,
3466
],
[
3466,
46,
597
]
],
[
[
322,
18,
6718
],
[
6718,
57,
597
]
],
[
[
322,
21,
29373
],
[
29373,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
]
],
[
[
"Epirubicin",
"{u} (Compound) upregulates {v} (Gene)",
"CCNA1"
],
[
"CCNA1",
"{u} (Gene) is upregulated by {... | Epirubicin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Chloramphenicol (Compound)
Epirubicin (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Chloramphenicol (Compound)
Epirubicin (Compound) causes Glossitis (Side Effect) and Glossitis (Side Effect) is caused by Chlo... |
DB00759 | DB08938 | 1,620 | 1,384 | [
"DDInter1783",
"DDInter1112"
] | Tetracycline | Magaldrate | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
1620,
24,
1384
]
],
[
[
1620,
63,
1252
],
[
1252,
23,
1384
]
],
[
[
1620,
24,
954
],
[
954,
23,
1384
]
],
[
[
1620,
1,
964
],
[
964,
... | [
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Tetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril m... |
DB01197 | DB01284 | 1,603 | 1,042 | [
"DDInter292",
"DDInter1782"
] | Captopril | Tetracosactide | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1603,
24,
1042
]
],
[
[
1603,
24,
761
],
[
761,
63,
1042
]
],
[
[
1603,
63,
1144
],
[
1144,
24,
1042
]
],
[
[
1603,
40,
610
],
[
610,
... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],
[... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and N... |
DB01128 | DB01208 | 918 | 945 | [
"DDInter204",
"DDInter1705"
] | Bicalutamide | Sparfloxacin | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Major | 2 | [
[
[
918,
25,
945
]
],
[
[
918,
63,
739
],
[
739,
1,
945
]
],
[
[
918,
64,
1176
],
[
1176,
1,
945
]
],
[
[
918,
24,
1539
],
[
1539,
1... | [
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
[
"Lo... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Bicalutamide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin (Compound)... |
DB01041 | DB01155 | 770 | 872 | [
"DDInter1789",
"DDInter813"
] | Thalidomide | Gemifloxacin | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
770,
24,
872
]
],
[
[
770,
63,
739
],
[
739,
1,
872
]
],
[
[
770,
24,
956
],
[
956,
1,
872
]
],
[
[
770,
24,
945
],
[
945,
40,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin and Norfloxacin (Compound) resembles Gemifloxacin... |
DB00446 | DB06186 | 597 | 1,439 | [
"DDInter351",
"DDInter969"
] | Chloramphenicol | Ipilimumab | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
597,
24,
1439
]
],
[
[
597,
24,
617
],
[
617,
24,
1439
]
],
[
[
597,
24,
1060
],
[
1060,
63,
1439
]
],
[
[
597,
63,
482
],
[
482,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab ... |
DB00738 | DB01246 | 485 | 820 | [
"DDInter1420",
"DDInter45"
] | Pentamidine | Alimemazine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
485,
24,
820
]
],
[
[
485,
24,
401
],
[
401,
24,
820
]
],
[
[
485,
63,
675
],
[
675,
25,
820
]
],
[
[
485,
63,
508
],
[
508,
1,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyp... |
DB00934 | DB06589 | 413 | 1,250 | [
"DDInter1124",
"DDInter1400"
] | Maprotiline | Pazopanib | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
413,
24,
1250
]
],
[
[
413,
6,
7950
],
[
7950,
45,
1250
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],
[
[
413,
18,
10656
],
[
10656,
46,
1250
]
],
[
[
413,
21,
28868
],
[
2886... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Maprotiline",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)"... | Maprotiline (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Maprotiline (Compound) downregulates PSMG1 (Gene) and PSMG1 (Gene) is upregulated by Pazopanib (Compound)
Maprotiline (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Pazopanib (Compound)
Ma... |
DB01267 | DB06292 | 519 | 549 | [
"DDInter1381",
"DDInter474"
] | Paliperidone | Dapagliflozin | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
519,
24,
549
]
],
[
[
519,
24,
1344
],
[
1344,
40,
549
]
],
[
[
519,
6,
8374
],
[
8374,
45,
549
]
],
[
[
519,
21,
29222
],
[
29222,
... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Paliperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Paliperidone (Compound) causes Hypoglycaemia (Side... |
DB00197 | DB00880 | 1,324 | 359 | [
"DDInter1881",
"DDInter360"
] | Troglitazone | Chlorothiazide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
1324,
24,
359
]
],
[
[
1324,
24,
1577
],
[
1577,
1,
359
]
],
[
[
1324,
24,
126
],
[
126,
23,
359
]
],
[
[
1324,
24,
688
],
[
688,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor inter... |
DB00358 | DB01403 | 1,010 | 9 | [
"DDInter1140",
"DDInter1175"
] | Mefloquine | Methotrimeprazine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1010,
24,
9
]
],
[
[
1010,
24,
1178
],
[
1178,
40,
9
]
],
[
[
1010,
24,
1164
],
[
1164,
1,
9
]
],
[
[
1010,
25,
684
],
[
684,
40... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles M... |
DB00927 | DB08871 | 1,559 | 36 | [
"DDInter712",
"DDInter666"
] | Famotidine | Eribulin | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1559,
24,
36
]
],
[
[
1559,
23,
1247
],
[
1247,
23,
36
]
],
[
[
1559,
24,
519
],
[
519,
24,
36
]
],
[
[
1559,
63,
1424
],
[
1424,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Eribulin
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone an... |
DB05015 | DB10795 | 1,077 | 221 | [
"DDInter174",
"DDInter1486"
] | Belinostat | Poliovirus type 1 antigen (formaldehyde inactivated) | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1077,
24,
221
]
],
[
[
1077,
64,
581
],
[
581,
24,
221
]
],
[
[
1077,
63,
599
],
[
599,
24,
221
]
],
[
[
1077,
24,
384
],
[
384,
... | [
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Belinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"... | Belinostat may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Belinostat may cause a moderate interaction that could exacerbate diseases when taken... |
DB00186 | DB01105 | 905 | 222 | [
"DDInter1092",
"DDInter1665"
] | Lorazepam | Sibutramine | Lorazepam is a short-acting and rapidly cleared benzodiazepine used commonly as a sedative and anxiolytic. It was developed by DJ Richards, presented and marketed initially by Wyeth Pharmaceuticals in the USA in 1977. The first historic FDA label approval is reported in 1985 by the company Mutual Pharm. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
905,
24,
222
]
],
[
[
905,
21,
29356
],
[
29356,
60,
222
]
],
[
[
905,
40,
1563
],
[
1563,
24,
222
]
],
[
[
905,
24,
128
],
[
128,
... | [
[
[
"Lorazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Lorazepam",
"{u} (Compound) causes {v} (Side Effect)",
"Salivary hypersecretion"
],
[
"Salivary hypersecretion",
... | Lorazepam (Compound) causes Salivary hypersecretion (Side Effect) and Salivary hypersecretion (Side Effect) is caused by Sibutramine (Compound)
Lorazepam (Compound) resembles Halazepam (Compound) and Halazepam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Lorazepam may caus... |
DB01004 | DB05273 | 563 | 507 | [
"DDInter806",
"DDInter1638"
] | Ganciclovir | Samarium (153Sm) lexidronam | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Moderate | 1 | [
[
[
563,
24,
507
]
],
[
[
563,
1,
248
],
[
248,
24,
507
]
],
[
[
563,
63,
196
],
[
196,
25,
507
]
],
[
[
563,
24,
1626
],
[
1626,
64... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Samarium (153Sm) lexidronam"
]
],
[
[
"Ganciclovir",
"{u} (Compound) resembles {v} (Compound)",
"Valganciclovir"
],
[
"Valganciclovir",
... | Ganciclovir (Compound) resembles Valganciclovir (Compound) and Val
Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Altretamine and Altretamine may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam
Ganciclovir may cause a moderate interac... |
DB00888 | DB01033 | 1,001 | 328 | [
"DDInter1133",
"DDInter1156"
] | Mechlorethamine | Mercaptopurine | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
1001,
24,
328
]
],
[
[
1001,
5,
11555
],
[
11555,
44,
328
]
],
[
[
1001,
21,
28681
],
[
28681,
60,
328
]
],
[
[
1001,
62,
1299
],
[
12... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Mechlorethamine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
... | Mechlorethamine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mercaptopurine (Compound)
Mechlorethamine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mercaptopurine (Compound)
Mechlorethamine may cause a minor interaction... |
DB00414 | DB00451 | 590 | 542 | [
"DDInter16",
"DDInter1064"
] | Acetohexamide | Levothyroxine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
590,
24,
542
]
],
[
[
590,
24,
624
],
[
624,
1,
542
]
],
[
[
590,
63,
1152
],
[
1152,
1,
542
]
],
[
[
590,
24,
752
],
[
752,
62,... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Levothyroxine (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Levothyroxine (... |
DB00176 | DB00530 | 529 | 1,195 | [
"DDInter770",
"DDInter667"
] | Fluvoxamine | Erlotinib | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Moderate | 1 | [
[
[
529,
24,
1195
]
],
[
[
529,
24,
883
],
[
883,
40,
1195
]
],
[
[
529,
6,
7950
],
[
7950,
45,
1195
]
],
[
[
529,
18,
2551
],
[
2551,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Erlotinib (Compound)
Fluvoxamine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Erlotinib (Compound)
Fluvoxamine (Compound) downregulates PFN1 (Gene) and PFN1 (Gene) is ... |
DB00009 | DB00078 | 1,271 | 1,172 | [
"DDInter56",
"DDInter898"
] | Alteplase | Ibritumomab tiuxetan | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Major | 2 | [
[
[
1271,
25,
1172
]
],
[
[
1271,
23,
539
],
[
539,
62,
1172
]
],
[
[
1271,
24,
578
],
[
578,
63,
1172
]
],
[
[
1271,
25,
707
],
[
707,
... | [
[
[
"Alteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibritumomab tiuxetan"
]
],
[
[
"Alteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsic... | Alteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Ibritumomab tiuxetan
Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagr... |
DB00350 | DB00490 | 1,214 | 946 | [
"DDInter1226",
"DDInter254"
] | Minoxidil | Buspirone | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Moderate | 1 | [
[
[
1214,
24,
946
]
],
[
[
1214,
24,
820
],
[
820,
63,
946
]
],
[
[
1214,
24,
999
],
[
999,
24,
946
]
],
[
[
1214,
63,
1648
],
[
1648,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Buspirone"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Buspirone
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and T... |
DB00524 | DB09134 | 811 | 1,552 | [
"DDInter1199",
"DDInter966"
] | Metolazone | Ioversol | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
811,
24,
1552
]
],
[
[
811,
1,
1605
],
[
1605,
24,
1552
]
],
[
[
811,
63,
1648
],
[
1648,
24,
1552
]
],
[
[
811,
40,
1014
],
[
1014,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Metolazone",
"{u} (Compound) resembles {v} (Compound)",
"Indapamide"
],
[
"Indapamide",
"{u} may cause a moderate ... | Metolazone (Compound) resembles Indapamide (Compound) and Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could... |
DB01344 | DB05351 | 1,231 | 101 | [
"DDInter1830",
"DDInter519"
] | Tolevamer | Dexlansoprazole | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
1231,
24,
101
]
],
[
[
1231,
24,
428
],
[
428,
63,
101
]
],
[
[
1231,
63,
1252
],
[
1252,
24,
101
]
],
[
[
1231,
24,
624
],
[
624,
... | [
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Tolevamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
],... | Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazole
Tolevamer may cause a moderate interaction that could exacerbate diseases when taken with Digoxi... |
DB00978 | DB06723 | 739 | 115 | [
"DDInter1084",
"DDInter58"
] | Lomefloxacin | Aluminum hydroxide | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
739,
24,
115
]
],
[
[
739,
21,
28775
],
[
28775,
60,
115
]
],
[
[
739,
64,
870
],
[
870,
23,
115
]
],
[
[
739,
63,
355
],
[
355,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Lomefloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Phlebitis"
],
[
"Phlebitis",
"{u} (Side Eff... | Lomefloxacin (Compound) causes Phlebitis (Side Effect) and Phlebitis (Side Effect) is caused by Aluminum hydroxide (Compound)
Lomefloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Al... |
DB00226 | DB00668 | 1,000 | 874 | [
"DDInter845",
"DDInter652"
] | Guanadrel | Epinephrine | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
1000,
24,
874
]
],
[
[
1000,
24,
1636
],
[
1636,
1,
874
]
],
[
[
1000,
24,
1148
],
[
1148,
63,
874
]
],
[
[
1000,
63,
1179
],
[
1179,
... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction t... |
DB06589 | DB11978 | 1,250 | 124 | [
"DDInter1400",
"DDInter822"
] | Pazopanib | Glasdegib | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1250,
24,
124
]
],
[
[
1250,
23,
1135
],
[
1135,
23,
124
]
],
[
[
1250,
62,
1247
],
[
1247,
23,
124
]
],
[
[
1250,
24,
466
],
[
466,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"N... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Pazopanib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethox... |
DB01142 | DB09128 | 1,264 | 1,241 | [
"DDInter593",
"DDInter231"
] | Doxepin | Brexpiprazole | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
1264,
24,
1241
]
],
[
[
1264,
24,
129
],
[
129,
24,
1241
]
],
[
[
1264,
24,
741
],
[
741,
63,
1241
]
],
[
[
1264,
63,
543
],
[
543,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolap... |
DB00934 | DB09268 | 413 | 1,662 | [
"DDInter1124",
"DDInter1464"
] | Maprotiline | Picosulfuric acid | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
413,
24,
1662
]
],
[
[
413,
24,
484
],
[
484,
63,
1662
]
],
[
[
413,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
413,
24,
1491
],
[
1491,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Maprotiline may lead to a major life threatening interaction when taken with Cabozantinib and Cabozant... |
DB00651 | DB01193 | 746 | 819 | [
"DDInter613",
"DDInter12"
] | Dyphylline | Acebutolol | Dyphylline is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis. | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Major | 2 | [
[
[
746,
25,
819
]
],
[
[
746,
25,
887
],
[
887,
1,
819
]
],
[
[
746,
64,
1121
],
[
1121,
1,
819
]
],
[
[
746,
21,
28762
],
[
28762,
... | [
[
[
"Dyphylline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acebutolol"
]
],
[
[
"Dyphylline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pindolol"
],
[
"Pindolol",
"{u} (Comp... | Dyphylline may lead to a major life threatening interaction when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Dyphylline may lead to a major life threatening interaction when taken with Bisoprolol and Bisoprolol (Compound) resembles Acebutolol (Compound)
Dyphylline (Compound) causes Heada... |
DB06674 | DB10989 | 908 | 496 | [
"DDInter837",
"DDInter858"
] | Golimumab | Hepatitis A Vaccine | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
908,
24,
496
]
],
[
[
908,
25,
1093
],
[
1093,
63,
496
]
],
[
[
908,
64,
4
],
[
4,
24,
496
]
],
[
[
908,
25,
850
],
[
850,
24,
... | [
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
],
[
"Ixe... | Golimumab may lead to a major life threatening interaction when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Golimumab may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine me... |
DB00572 | DB00782 | 85 | 1,123 | [
"DDInter136",
"DDInter1535"
] | Atropine | Propantheline | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
85,
24,
1123
]
],
[
[
85,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
85,
21,
28898
],
[
28898,
60,
1123
]
],
[
[
85,
23,
359
],
[
359,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Atropine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
... | Atropine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Atropine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Atropine may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide an... |
DB00209 | DB00843 | 352 | 479 | [
"DDInter1886",
"DDInter583"
] | Trospium | Donepezil | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Moderate | 1 | [
[
[
352,
24,
479
]
],
[
[
352,
6,
12523
],
[
12523,
45,
479
]
],
[
[
352,
21,
29220
],
[
29220,
60,
479
]
],
[
[
352,
24,
1442
],
[
1442,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
]
],
[
[
"Trospium",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Donepezil (Compound)
Trospium (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Donepezil (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Scopo... |
DB00063 | DB00586 | 366 | 1,512 | [
"DDInter659",
"DDInter537"
] | Eptifibatide | Diclofenac | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
366,
24,
1512
]
],
[
[
366,
23,
297
],
[
297,
62,
1512
]
],
[
[
366,
24,
885
],
[
885,
63,
1512
]
],
[
[
366,
64,
1271
],
[
1271,
... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
... | Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Diclofenac
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol m... |
DB01044 | DB06595 | 246 | 1,491 | [
"DDInter809",
"DDInter1214"
] | Gatifloxacin | Midostaurin | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
246,
25,
1491
]
],
[
[
246,
62,
112
],
[
112,
23,
1491
]
],
[
[
246,
25,
761
],
[
761,
24,
1491
]
],
[
[
246,
64,
888
],
[
888,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Gatifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Gatifloxacin may lead to a major life threatening interaction when taken with Saxagliptin and Saxagliptin m... |
DB00286 | DB00635 | 380 | 1,573 | [
"DDInter439",
"DDInter1515"
] | Conjugated estrogens | Prednisone | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Moderate | 1 | [
[
[
380,
24,
1573
]
],
[
[
380,
24,
175
],
[
175,
40,
1573
]
],
[
[
380,
24,
1547
],
[
1547,
1,
1573
]
],
[
[
380,
5,
11562
],
[
11562,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamci... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Exemestane and Exemestane (Compound) resemb... |
DB00675 | DB15982 | 888 | 1,339 | [
"DDInter1744",
"DDInter193"
] | Tamoxifen | Berotralstat | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
888,
24,
1339
]
],
[
[
888,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
888,
25,
283
],
[
283,
23,
1339
]
],
[
[
888,
24,
1213
],
[
1213,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Tamoxifen may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a ... |
DB09473 | DB12834 | 884 | 148 | [
"DDInter918",
"DDInter1649"
] | Indium In-111 oxyquinoline | Secnidazole | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
884,
24,
148
]
],
[
[
884,
24,
1434
],
[
1434,
24,
148
]
],
[
[
884,
63,
597
],
[
597,
24,
148
]
],
[
[
884,
24,
1434
],
[
1434,
... | [
[
[
"Indium In-111 oxyquinoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Indium In-111 oxyquinoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Indium In-111 oxyquinoline may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole and Benznidazole may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Indium In-111 oxyquinoline may cause a moderate interaction that could exacerbate diseases ... |
DB00524 | DB01234 | 811 | 1,220 | [
"DDInter1199",
"DDInter513"
] | Metolazone | Dexamethasone | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
811,
24,
1220
]
],
[
[
811,
24,
870
],
[
870,
1,
1220
]
],
[
[
811,
24,
175
],
[
175,
40,
1220
]
],
[
[
811,
63,
218
],
[
218,
1... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB00006 | DB08896 | 942 | 292 | [
"DDInter217",
"DDInter1576"
] | Bivalirudin | Regorafenib | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
942,
25,
292
]
],
[
[
942,
24,
643
],
[
643,
24,
292
]
],
[
[
942,
24,
41
],
[
41,
63,
292
]
],
[
[
942,
25,
553
],
[
553,
25,
... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
],
[
"Des... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Levomilnac... |
DB01278 | DB08870 | 1,021 | 850 | [
"DDInter1506",
"DDInter228"
] | Pramlintide | Brentuximab vedotin | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1021,
24,
850
]
],
[
[
1021,
63,
1142
],
[
1142,
24,
850
]
],
[
[
1021,
24,
1033
],
[
1033,
63,
850
]
],
[
[
1021,
24,
651
],
[
651,
... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
],... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and ... |
DB00835 | DB11160 | 100 | 337 | [
"DDInter245",
"DDInter1459"
] | Brompheniramine | Phenyltoloxamine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
100,
24,
337
]
],
[
[
100,
23,
771
],
[
771,
62,
337
]
],
[
[
100,
24,
820
],
[
820,
24,
337
]
],
[
[
100,
63,
999
],
[
999,
24,... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Brompheniramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase... | Brompheniramine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Phenyltoloxamine
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ali... |
DB00218 | DB11093 | 1,176 | 636 | [
"DDInter1247",
"DDInter273"
] | Moxifloxacin | Calcium citrate | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1176,
24,
636
]
],
[
[
1176,
1,
739
],
[
739,
24,
636
]
],
[
[
1176,
24,
115
],
[
115,
25,
636
]
],
[
[
1176,
1,
739
],
[
739,
4... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u} may ca... | Moxifloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide and Aluminum hydroxide may lead to a ... |
DB00295 | DB12015 | 475 | 1,033 | [
"DDInter1244",
"DDInter53"
] | Morphine | Alpelisib | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
475,
24,
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[
[
475,
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[
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[
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475,
24,
772
],
[
772,
24,
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]
],
[
[
475,
23,
122
],
[
122,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurasidone"
],
[
"Lurasidone",
... | Morphine may lead to a major life threatening interaction when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Carvedilol and Carvedilol may cause a mod... |
DB00029 | DB01009 | 25 | 935 | [
"DDInter99",
"DDInter1009"
] | Anistreplase | Ketoprofen | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Moderate | 1 | [
[
[
25,
24,
935
]
],
[
[
25,
24,
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],
[
1274,
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[
[
25,
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],
[
886,
1,
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]
],
[
[
25,
25,
1046
],
[
1046,
63,
... | [
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
]
],
[
[
"Anistreplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
],
... | Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and... |
DB08873 | DB11828 | 74 | 1,406 | [
"DDInter221",
"DDInter1281"
] | Boceprevir | Neratinib | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
74,
25,
1406
]
],
[
[
74,
25,
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],
[
1135,
23,
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[
[
74,
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392
],
[
392,
24,
1406
]
],
[
[
74,
63,
1195
],
[
1195,
... | [
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Boceprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Boceprevir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Boceprevir may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interaction... |
DB12161 | DB12500 | 730 | 283 | [
"DDInter512",
"DDInter714"
] | Deutetrabenazine | Fedratinib | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated. The presence of deuterium in deutetrabenazine increases the half-lives o... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
730,
24,
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]
],
[
[
730,
64,
351
],
[
351,
23,
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]
],
[
[
730,
63,
600
],
[
600,
24,
283
]
],
[
[
730,
64,
401
],
[
401,
24,... | [
[
[
"Deutetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Deutetrabenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
... | Deutetrabenazine may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Deutetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazol... |
DB08815 | DB08816 | 154 | 578 | [
"DDInter1104",
"DDInter1802"
] | Lurasidone | Ticagrelor | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
154,
24,
578
]
],
[
[
154,
6,
8374
],
[
8374,
45,
578
]
],
[
[
154,
21,
28646
],
[
28646,
60,
578
]
],
[
[
154,
64,
723
],
[
723,
... | [
[
[
"Lurasidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Lurasidone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Lurasidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Lurasidone (Compound) causes Unspecified disorder of skin and subcutaneous tissue (Side Effect) and Unspecified disorder of skin and subcutaneous tissue (Side Effect) is caused by Ticagrelor (Compound)
Lurasidone may lead to a... |
DB00400 | DB06616 | 353 | 594 | [
"DDInter843",
"DDInter224"
] | Griseofulvin | Bosutinib | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
353,
24,
594
]
],
[
[
353,
63,
883
],
[
883,
1,
594
]
],
[
[
353,
6,
8374
],
[
8374,
45,
594
]
],
[
[
353,
18,
15501
],
[
15501,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Griseofulvin (Compound) downregulates CCDC86 (Gene) and CCDC86 (Ge... |
DB00213 | DB06616 | 837 | 594 | [
"DDInter1388",
"DDInter224"
] | Pantoprazole | Bosutinib | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
837,
24,
594
]
],
[
[
837,
24,
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[
883,
1,
594
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],
[
[
837,
6,
8374
],
[
8374,
45,
594
]
],
[
[
837,
18,
5833
],
[
5833,
4... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
... | Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Pantoprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Pantoprazole (Compound) downregulates ACAT2 (Gene) and ACAT2 (Gene... |
DB00552 | DB00694 | 1,238 | 51 | [
"DDInter1425",
"DDInter485"
] | Pentostatin | Daunorubicin | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Moderate | 1 | [
[
[
1238,
24,
51
]
],
[
[
1238,
5,
11555
],
[
11555,
44,
51
]
],
[
[
1238,
21,
28671
],
[
28671,
60,
51
]
],
[
[
1238,
23,
739
],
[
739,
... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
]
],
[
[
"Pentostatin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Di... | Pentostatin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Daunorubicin (Compound)
Pentostatin (Compound) causes Dysphagia (Side Effect) and Dysphagia (Side Effect) is caused by Daunorubicin (Compound)
Pentostatin may cause a minor interaction that can limit clinical effec... |
DB00346 | DB06663 | 472 | 1,154 | [
"DDInter44",
"DDInter1398"
] | Alfuzosin | Pasireotide | Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over ... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
472,
25,
1154
]
],
[
[
472,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
472,
23,
112
],
[
112,
23,
1154
]
],
[
[
472,
24,
1662
],
[
1662,
... | [
[
[
"Alfuzosin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Alfuzosin",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused by ... | Alfuzosin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Alfuzosin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00580 | DB06779 | 311 | 365 | [
"DDInter1910",
"DDInter470"
] | Valdecoxib | Dalteparin | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Moderate | 1 | [
[
[
311,
24,
365
]
],
[
[
311,
63,
305
],
[
305,
24,
365
]
],
[
[
311,
24,
298
],
[
298,
63,
365
]
],
[
[
311,
63,
1018
],
[
1018,
2... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalteparin"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia co... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin
Valdecoxib may cause a moderate interaction that could exacerbate diseases... |
DB00782 | DB00850 | 1,123 | 1,630 | [
"DDInter1535",
"DDInter1432"
] | Propantheline | Perphenazine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
1123,
24,
1630
]
],
[
[
1123,
63,
252
],
[
252,
40,
1630
]
],
[
[
1123,
24,
673
],
[
673,
40,
1630
]
],
[
[
1123,
21,
29232
],
[
29232... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Perphena... |
DB00681 | DB01199 | 1,287 | 1,217 | [
"DDInter85",
"DDInter1890"
] | Amphotericin B | Tubocurarine | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Tubocurarine is a non-depolarizing neuromuscular blocking agent and the first identified curare alkaloid. Curare is one of the names used to describe plant-derived poisons used by indigenous South Americans to coat the tips of hunting arrows and darts, which were typically derived from plants of the genera _Chondrodend... | Moderate | 1 | [
[
[
1287,
24,
1217
]
],
[
[
1287,
24,
545
],
[
545,
1,
1217
]
],
[
[
1287,
63,
1573
],
[
1573,
24,
1217
]
],
[
[
1287,
24,
891
],
[
891,
... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarine"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurine"
]... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Metocurine and Metocurine (Compound) resembles Tubocurarine (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction ... |
DB00582 | DB11921 | 1,622 | 1,019 | [
"DDInter1946",
"DDInter492"
] | Voriconazole | Deflazacort | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
1622,
25,
1019
]
],
[
[
1622,
25,
959
],
[
959,
24,
1019
]
],
[
[
1622,
24,
1619
],
[
1619,
63,
1019
]
],
[
[
1622,
24,
761
],
[
761,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glipizide"
],
[
"Glipizide",
"{u... | Voriconazole may lead to a major life threatening interaction when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause... |
DB00224 | DB11760 | 215 | 119 | [
"DDInter917",
"DDInter1742"
] | Indinavir | Talazoparib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
215,
24,
119
]
],
[
[
215,
25,
985
],
[
985,
24,
119
]
],
[
[
215,
25,
1406
],
[
1406,
63,
119
]
],
[
[
215,
24,
292
],
[
292,
2... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
],
[
"Osimertini... | Indinavir may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Indinavir may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a moderate inter... |
DB00390 | DB08881 | 1,252 | 868 | [
"DDInter554",
"DDInter1925"
] | Digoxin | Vemurafenib | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
1252,
24,
868
]
],
[
[
1252,
6,
8374
],
[
8374,
45,
868
]
],
[
[
1252,
7,
7972
],
[
7972,
46,
868
]
],
[
[
1252,
18,
2097
],
[
2097,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Digoxin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Digoxin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Digoxin (Compound) upregulates COL11A1 (Gene) and COL11A1 (Gene) is upregulated by Vemurafenib (Compound)
Digoxin (Compound) downregulates ERBB2 (Gene) and ERBB2 (Gene) is upregulated by Vemurafenib (Compound)
Digoxin (Compound)... |
DB00451 | DB11093 | 542 | 636 | [
"DDInter1064",
"DDInter273"
] | Levothyroxine | Calcium citrate | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
542,
24,
636
]
],
[
[
542,
23,
819
],
[
819,
24,
636
]
],
[
[
542,
62,
88
],
[
88,
24,
636
]
],
[
[
542,
24,
1482
],
[
1482,
24,... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
],... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol and... |
DB00398 | DB00468 | 79 | 1,424 | [
"DDInter1702",
"DDInter1557"
] | Sorafenib | Quinine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Moderate | 1 | [
[
[
79,
24,
1424
]
],
[
[
79,
6,
21998
],
[
21998,
45,
1424
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],
[
[
79,
7,
5998
],
[
5998,
46,
1424
]
],
[
[
79,
7,
3696
],
[
3696,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
]
],
[
[
"Sorafenib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by {v}... | Sorafenib (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Quinine (Compound)
Sorafenib (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Quinine (Compound)
Sorafenib (Compound) upregulates ALAS1 (Gene) and ALAS1 (Gene) is downregulated by Quinine (Compound)
Sorafenib ... |
DB00451 | DB00865 | 542 | 939 | [
"DDInter1064",
"DDInter187"
] | Levothyroxine | Benzphetamine | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Moderate | 1 | [
[
[
542,
24,
939
]
],
[
[
542,
24,
1529
],
[
1529,
1,
939
]
],
[
[
542,
63,
80
],
[
80,
40,
939
]
],
[
[
542,
63,
362
],
[
362,
1,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Benzphetamine (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Benzp... |
DB06595 | DB06643 | 1,491 | 1,136 | [
"DDInter1214",
"DDInter500"
] | Midostaurin | Denosumab | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
1491,
24,
1136
]
],
[
[
1491,
63,
1213
],
[
1213,
24,
1136
]
],
[
[
1491,
64,
1377
],
[
1377,
24,
1136
]
],
[
[
1491,
25,
39
],
[
39,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
[
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Midostaurin may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause... |
DB00679 | DB01309 | 684 | 1,254 | [
"DDInter1796",
"DDInter933"
] | Thioridazine | Insulin glulisine | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
684,
24,
1254
]
],
[
[
684,
25,
1621
],
[
1621,
23,
1254
]
],
[
[
684,
24,
274
],
[
274,
23,
1254
]
],
[
[
684,
64,
1424
],
[
1424,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
],
... | Thioridazine may lead to a major life threatening interaction when taken with Potassium chloride and Potassium chloride may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamin... |
DB00476 | DB06803 | 109 | 769 | [
"DDInter608",
"DDInter1288"
] | Duloxetine | Niclosamide | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Niclosamide is an antihelminthic used for the treatment of tapeworm infections. Helminths (worms) are multicellular organisms that infect very large numbers of humans and cause a broad range of diseases. Over 1 billion people are infected with intestinal nematodes, and many millions are infected with filarial nematodes... | Moderate | 1 | [
[
[
109,
24,
769
]
],
[
[
109,
6,
7950
],
[
7950,
45,
769
]
],
[
[
109,
7,
13230
],
[
13230,
46,
769
]
],
[
[
109,
18,
3682
],
[
3682,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niclosamide"
]
],
[
[
"Duloxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)"... | Duloxetine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Niclosamide (Compound)
Duloxetine (Compound) upregulates TIPARP (Gene) and TIPARP (Gene) is upregulated by Niclosamide (Compound)
Duloxetine (Compound) downregulates PIN1 (Gene) and PIN1 (Gene) is downregulated by Niclosamide (Compound)
Duloxetine ... |
DB00641 | DB01263 | 467 | 859 | [
"DDInter1675",
"DDInter1494"
] | Simvastatin | Posaconazole | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Major | 2 | [
[
[
467,
25,
859
]
],
[
[
467,
6,
4973
],
[
4973,
45,
859
]
],
[
[
467,
21,
28762
],
[
28762,
60,
859
]
],
[
[
467,
24,
112
],
[
112,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Posaconazole"
]
],
[
[
"Simvastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Posac... | Simvastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Simvastatin (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole an... |
DB00180 | DB13179 | 1,351 | 68 | [
"DDInter749",
"DDInter1882"
] | Flunisolide | Troleandomycin | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | A macrolide antibiotic that is similar to erythromycin. | Moderate | 1 | [
[
[
1351,
24,
68
]
],
[
[
1351,
40,
251
],
[
251,
24,
68
]
],
[
[
1351,
24,
760
],
[
760,
24,
68
]
],
[
[
1351,
23,
659
],
[
659,
24... | [
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troleandomycin"
]
],
[
[
"Flunisolide",
"{u} (Compound) resembles {v} (Compound)",
"Betamethasone"
],
[
"Betamethasone",
"{u} may cau... | Flunisolide (Compound) resembles Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Troleandomycin
Flunisolide may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interactio... |
DB00317 | DB09048 | 883 | 555 | [
"DDInter810",
"DDInter1284"
] | Gefitinib | Netupitant | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
883,
24,
555
]
],
[
[
883,
63,
1101
],
[
1101,
23,
555
]
],
[
[
883,
24,
283
],
[
283,
62,
555
]
],
[
[
883,
63,
1324
],
[
1324,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib... |
DB00995 | DB01087 | 1,112 | 1,520 | [
"DDInter139",
"DDInter1520"
] | Auranofin | Primaquine | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Major | 2 | [
[
[
1112,
25,
1520
]
],
[
[
1112,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
1112,
21,
28722
],
[
28722,
60,
1520
]
],
[
[
1112,
63,
112
],
[
1... | [
[
[
"Auranofin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
]
],
[
[
"Auranofin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydroxychloroquine"... | Auranofin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Auranofin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Primaquine (Compound)
Auranofin may caus... |
DB00331 | DB01579 | 1,645 | 341 | [
"DDInter1164",
"DDInter1439"
] | Metformin | Phendimetrazine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Moderate | 1 | [
[
[
1645,
24,
341
]
],
[
[
1645,
21,
28662
],
[
28662,
60,
341
]
],
[
[
1645,
24,
959
],
[
959,
24,
341
]
],
[
[
1645,
24,
1296
],
[
1296,... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Metformin",
"{u} (Compound) causes {v} (Side Effect)",
"Tremor"
],
[
"Tremor",
"{u} (Side Effect) is caused ... | Metformin (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Phendimetrazine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Phendimetraz... |
DB00388 | DB01173 | 1,636 | 358 | [
"DDInter1453",
"DDInter1349"
] | Phenylephrine | Orphenadrine | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
1636,
24,
358
]
],
[
[
1636,
24,
939
],
[
939,
1,
358
]
],
[
[
1636,
25,
1164
],
[
1164,
1,
358
]
],
[
[
1636,
63,
847
],
[
847,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Orphenadrine (Compound)
Phenylephrine may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine (Compound) resembles Orphenadrine (Compo... |
DB00490 | DB08912 | 946 | 1,040 | [
"DDInter254",
"DDInter462"
] | Buspirone | Dabrafenib | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
946,
24,
1040
]
],
[
[
946,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
946,
7,
6692
],
[
6692,
46,
1040
]
],
[
[
946,
7,
6314
],
[
6314,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Buspirone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Buspirone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Buspirone (Compound) upregulates CGRRF1 (Gene) and CGRRF1 (Gene) is upregulated by Dabrafenib (Compound)
Buspirone (Compound) upregulates TLR4 (Gene) and TLR4 (Gene) is downregulated by Dabrafenib (Compound)
Buspirone (Compound) ... |
DB06176 | DB08908 | 1,342 | 713 | [
"DDInter1616",
"DDInter564"
] | Romidepsin | Dimethyl fumarate | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1342,
24,
713
]
],
[
[
1342,
25,
996
],
[
996,
24,
713
]
],
[
[
1342,
63,
4
],
[
4,
24,
713
]
],
[
[
1342,
24,
1250
],
[
1250,
2... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
],
[
"Be... | Romidepsin may lead to a major life threatening interaction when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate a... |
DB09123 | DB11828 | 1,525 | 1,406 | [
"DDInter546",
"DDInter1281"
] | Dienogest | Neratinib | Dienogest is an orally-active semisynthetic progestogen which also possesses the properties of 17α-hydroxyprogesterone. It is a derivative of 19-nortestosterone and has antiandrogenic properties. It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
1525,
24,
1406
]
],
[
[
1525,
63,
1510
],
[
1510,
24,
1406
]
],
[
[
1525,
64,
1040
],
[
1040,
25,
1406
]
],
[
[
1525,
63,
1510
],
[
15... | [
[
[
"Dienogest",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Dienogest",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
],
[
... | Dienogest may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Dienogest may lead to a major life threatening interaction when taken with Dabrafenib and Dabrafenib may lea... |
DB00373 | DB09039 | 461 | 1,670 | [
"DDInter1809",
"DDInter629"
] | Timolol | Eliglustat | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
461,
24,
1670
]
],
[
[
461,
24,
478
],
[
478,
24,
1670
]
],
[
[
461,
23,
578
],
[
578,
24,
1670
]
],
[
[
461,
24,
1476
],
[
1476,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
"Ni... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Timolol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticagrelor may c... |
DB01169 | DB11901 | 57 | 913 | [
"DDInter120",
"DDInter107"
] | Arsenic trioxide | Apalutamide | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
57,
25,
913
]
],
[
[
57,
62,
112
],
[
112,
23,
913
]
],
[
[
57,
64,
600
],
[
600,
24,
913
]
],
[
[
57,
24,
28
],
[
28,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Arsenic trioxide may lead to a major life threatening interaction when taken with Fluconazole and Fluco... |
DB00224 | DB00284 | 215 | 1,647 | [
"DDInter917",
"DDInter11"
] | Indinavir | Acarbose | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Moderate | 1 | [
[
[
215,
24,
1647
]
],
[
[
215,
18,
4893
],
[
4893,
57,
1647
]
],
[
[
215,
21,
28734
],
[
28734,
60,
1647
]
],
[
[
215,
24,
1645
],
[
1645... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
]
],
[
[
"Indinavir",
"{u} (Compound) downregulates {v} (Gene)",
"S100A13"
],
[
"S100A13",
"{u} (Gene) is downregulated by {v... | Indinavir (Compound) downregulates S100A13 (Gene) and S100A13 (Gene) is downregulated by Acarbose (Compound)
Indinavir (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Acarbose (Compound)
Indinavir may cause a moderate interaction that could exacerbate disease... |
DB00049 | DB00807 | 737 | 1,120 | [
"DDInter1573",
"DDInter1536"
] | Rasburicase | Proparacaine (ophthalmic) | Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified <i>Saccharomyces cerevisiae</i> strain. The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_. | Proparacaine is a benzoate ester. | Moderate | 1 | [
[
[
737,
24,
1120
]
],
[
[
737,
24,
384
],
[
384,
63,
33
],
[
33,
40,
1120
]
],
[
[
737,
24,
290
],
[
290,
6,
11001
],
[
11001,
45,
... | [
[
[
"Rasburicase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Proparacaine"
]
],
[
[
"Rasburicase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Rasburicase may cause a moderate interaction that could exacerbate diseases when taken with Proparacaine
Rasburicase may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Am... |
DB01259 | DB05351 | 392 | 101 | [
"DDInter1024",
"DDInter519"
] | Lapatinib | Dexlansoprazole | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
392,
24,
101
]
],
[
[
392,
25,
1069
],
[
1069,
23,
101
]
],
[
[
392,
63,
1347
],
[
1347,
23,
101
]
],
[
[
392,
24,
263
],
[
263,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
],
[
"Vandeta... | Lapatinib may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may cau... |
DB00717 | DB01261 | 1,197 | 170 | [
"DDInter1312",
"DDInter1679"
] | Norethisterone | Sitagliptin | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1197,
24,
170
]
],
[
[
1197,
6,
8374
],
[
8374,
45,
170
]
],
[
[
1197,
18,
7885
],
[
7885,
46,
170
]
],
[
[
1197,
18,
4700
],
[
4700,
... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Norethisterone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Norethisterone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sitagliptin (Compound)
Norethisterone (Compound) downregulates MELK (Gene) and MELK (Gene) is upregulated by Sitagliptin (Compound)
Norethisterone (Compound) downregulates TCEA2 (Gene) and TCEA2 (Gene) is downregulated by Sitagliptin (Compound)... |
DB00673 | DB01126 | 723 | 1,260 | [
"DDInter112",
"DDInter611"
] | Aprepitant | Dutasteride | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Moderate | 1 | [
[
[
723,
24,
1260
]
],
[
[
723,
6,
7524
],
[
7524,
45,
1260
]
],
[
[
723,
21,
28921
],
[
28921,
60,
1260
]
],
[
[
723,
24,
129
],
[
129,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dutasteride"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)"... | Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Dutasteride (Compound)
Aprepitant (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Dutasteride (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and ... |
DB01136 | DB01284 | 772 | 1,042 | [
"DDInter305",
"DDInter1782"
] | Carvedilol | Tetracosactide | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
772,
24,
1042
]
],
[
[
772,
64,
455
],
[
455,
23,
1042
]
],
[
[
772,
63,
1148
],
[
1148,
23,
1042
]
],
[
[
772,
25,
659
],
[
659,
... | [
[
[
"Carvedilol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Carvedilol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Salmeterol"
],
[
"Salmet... | Carvedilol may lead to a major life threatening interaction when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Tetracosactide
Carvedilol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may ... |
DB00014 | DB09078 | 521 | 1,228 | [
"DDInter839",
"DDInter1036"
] | Goserelin | Lenvatinib | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
521,
24,
1228
]
],
[
[
521,
23,
112
],
[
112,
23,
1228
]
],
[
[
521,
24,
1100
],
[
1100,
24,
1228
]
],
[
[
521,
24,
938
],
[
938,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venla... |
DB00745 | DB11921 | 307 | 1,019 | [
"DDInter1236",
"DDInter492"
] | Modafinil | Deflazacort | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
307,
25,
1019
]
],
[
[
307,
23,
1619
],
[
1619,
63,
1019
]
],
[
[
307,
23,
761
],
[
761,
24,
1019
]
],
[
[
307,
24,
629
],
[
629,
... | [
[
[
"Modafinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rucaparib"
],
[
"Rucaparib",
... | Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Modafinil may cause a minor interaction that can limit clinical effects when taken with Saxagliptin and Saxagliptin ... |
DB00804 | DB04861 | 1,507 | 1,592 | [
"DDInter543",
"DDInter1271"
] | Dicyclomine | Nebivolol | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1507,
24,
1592
]
],
[
[
1507,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
1507,
24,
1528
],
[
1528,
24,
1592
]
],
[
[
1507,
63,
1123
],
[
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Dicyclomine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cause... | Dicyclomine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine and Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Ne... |
DB00399 | DB01041 | 963 | 770 | [
"DDInter1968",
"DDInter1789"
] | Zoledronic acid | Thalidomide | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
963,
24,
770
]
],
[
[
963,
21,
29177
],
[
29177,
60,
770
]
],
[
[
963,
24,
1228
],
[
1228,
63,
770
]
],
[
[
963,
1,
1199
],
[
1199,
... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Zoledronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Musculoskeletal stiffness"
],
[
"Musculoskeletal s... | Zoledronic acid (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Thalidomide (Compound)
Zoledronic acid may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib and Lenvatinib may cause a moderate interaction that could ... |
DB00694 | DB12245 | 51 | 823 | [
"DDInter485",
"DDInter1863"
] | Daunorubicin | Triclabendazole | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
51,
24,
823
]
],
[
[
51,
23,
1247
],
[
1247,
23,
823
]
],
[
[
51,
24,
1612
],
[
1612,
24,
823
]
],
[
[
51,
63,
1010
],
[
1010,
2... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Fost... |
DB00176 | DB05239 | 529 | 866 | [
"DDInter770",
"DDInter425"
] | Fluvoxamine | Cobimetinib | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
529,
24,
866
]
],
[
[
529,
24,
214
],
[
214,
63,
866
]
],
[
[
529,
24,
888
],
[
888,
24,
866
]
],
[
[
529,
25,
1406
],
[
1406,
6... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and ... |
DB00242 | DB01033 | 1,064 | 328 | [
"DDInter392",
"DDInter1156"
] | Cladribine | Mercaptopurine | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Major | 2 | [
[
[
1064,
25,
328
]
],
[
[
1064,
5,
11555
],
[
11555,
44,
328
]
],
[
[
1064,
6,
13418
],
[
13418,
45,
328
]
],
[
[
1064,
21,
29662
],
[
29... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Cladribine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treat... | Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Mercaptopurine (Compound)
Cladribine (Compound) binds SLC28A3 (Gene) and SLC28A3 (Gene) is bound by Mercaptopurine (Compound)
Cladribine (Compound) causes Candida infection (Side Effect) and Candida infection (Side ... |
DB06605 | DB11986 | 1,409 | 484 | [
"DDInter108",
"DDInter648"
] | Apixaban | Entrectinib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1409,
24,
484
]
],
[
[
1409,
63,
222
],
[
222,
23,
484
]
],
[
[
1409,
64,
998
],
[
998,
24,
484
]
],
[
[
1409,
24,
1320
],
[
1320,
... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Apixaban may lead to a major life threatening interaction when taken with Phenylbutazone and Phenylbutazone may c... |
DB00612 | DB01234 | 1,121 | 1,220 | [
"DDInter216",
"DDInter513"
] | Bisoprolol | Dexamethasone | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
1121,
24,
1220
]
],
[
[
1121,
24,
870
],
[
870,
1,
1220
]
],
[
[
1121,
24,
175
],
[
175,
40,
1220
]
],
[
[
1121,
63,
251
],
[
251,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dex... |
DB00717 | DB09046 | 1,197 | 1,094 | [
"DDInter1312",
"DDInter1201"
] | Norethisterone | Metreleptin | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
1197,
24,
1094
]
],
[
[
1197,
24,
1213
],
[
1213,
24,
1094
]
],
[
[
1197,
63,
1031
],
[
1031,
24,
1094
]
],
[
[
1197,
40,
1657
],
[
16... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
... | Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin
Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Theophylline a... |
DB00001 | DB00261 | 1,578 | 702 | [
"DDInter1037",
"DDInter93"
] | Lepirudin | Anagrelide | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Major | 2 | [
[
[
1578,
25,
702
]
],
[
[
1578,
23,
539
],
[
539,
62,
702
]
],
[
[
1578,
24,
935
],
[
935,
63,
702
]
],
[
[
1578,
24,
529
],
[
529,
... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anagrelide"
]
],
[
[
"Lepirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Lepirudin may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Anagrelide
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may c... |
DB00647 | DB01176 | 675 | 537 | [
"DDInter528",
"DDInter453"
] | Dextropropoxyphene | Cyclizine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Major | 2 | [
[
[
675,
25,
537
]
],
[
[
675,
24,
1511
],
[
1511,
63,
537
]
],
[
[
675,
40,
11244
],
[
11244,
1,
537
]
],
[
[
675,
25,
104
],
[
104,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclizine"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Dextropropoxyphene (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Cyc... |
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