drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00010 | DB06335 | 1,649 | 761 | [
"DDInter1661",
"DDInter1646"
] | Sermorelin | Saxagliptin | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1649,
24,
761
]
],
[
[
1649,
24,
1296
],
[
1296,
63,
761
]
],
[
[
1649,
24,
1179
],
[
1179,
24,
761
]
],
[
[
1649,
24,
1296
],
[
1296,... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
],
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin ... |
DB00582 | DB13074 | 1,622 | 877 | [
"DDInter1946",
"DDInter1110"
] | Voriconazole | Macimorelin | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1622,
25,
877
]
],
[
[
1622,
23,
112
],
[
112,
23,
877
]
],
[
[
1622,
25,
1320
],
[
1320,
24,
877
]
],
[
[
1622,
24,
913
],
[
913,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Voriconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Voriconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Voriconazole may lead to a major life threatening interaction when taken with Elagolix and Elagolix may cau... |
DB00722 | DB06655 | 743 | 5 | [
"DDInter1079",
"DDInter1077"
] | Lisinopril | Liraglutide | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Minor | 0 | [
[
[
743,
23,
5
]
],
[
[
743,
63,
870
],
[
870,
24,
5
]
],
[
[
743,
24,
708
],
[
708,
24,
5
]
],
[
[
743,
24,
1019
],
[
1019,
63,
... | [
[
[
"Lisinopril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Liraglutide"
]
],
[
[
"Lisinopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Corticotro... |
DB00189 | DB00486 | 459 | 1,614 | [
"DDInter691",
"DDInter1253"
] | Ethchlorvynol | Nabilone | Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
459,
24,
1614
]
],
[
[
459,
24,
530
],
[
530,
1,
1614
]
],
[
[
459,
24,
516
],
[
516,
63,
1614
]
],
[
[
459,
24,
1242
],
[
1242,
... | [
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interactio... |
DB11952 | DB12941 | 800 | 466 | [
"DDInter612",
"DDInter481"
] | Duvelisib | Darolutamide | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
800,
23,
466
]
],
[
[
800,
63,
1374
],
[
1374,
23,
466
]
],
[
[
800,
24,
283
],
[
283,
23,
466
]
],
[
[
800,
25,
484
],
[
484,
2... | [
[
[
"Duvelisib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Duvelisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[
... | Duvelisib may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Duvelisib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB00076 | DB00420 | 1,352 | 508 | [
"DDInter555",
"DDInter1532"
] | Digoxin Immune Fab (Ovine) | Promazine | Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin. | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Moderate | 1 | [
[
[
1352,
24,
508
]
],
[
[
1352,
24,
1178
],
[
1178,
1,
508
]
],
[
[
1352,
24,
684
],
[
684,
40,
508
]
],
[
[
1352,
25,
57
],
[
57,
... | [
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
]
],
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Digoxin Immune Fab (Ovine) may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Promazine (Compound)
Digoxin Immune Fab (Ovine) may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazin... |
DB00365 | DB00539 | 839 | 11 | [
"DDInter842",
"DDInter1837"
] | Grepafloxacin | Toremifene | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
839,
25,
11
]
],
[
[
839,
23,
112
],
[
112,
62,
11
]
],
[
[
839,
24,
723
],
[
723,
63,
11
]
],
[
[
839,
25,
1144
],
[
1144,
63,
... | [
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Toremifene
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant an... |
DB00486 | DB00700 | 1,614 | 312 | [
"DDInter1253",
"DDInter656"
] | Nabilone | Eplerenone | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Moderate | 1 | [
[
[
1614,
24,
312
]
],
[
[
1614,
63,
443
],
[
443,
1,
312
]
],
[
[
1614,
21,
28882
],
[
28882,
60,
312
]
],
[
[
1614,
24,
849
],
[
849,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Spironolactone"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone (Compound) resembles Eplerenone (Compound)
Nabilone (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Eplerenone (Compound)
Nabilo... |
DB09280 | DB12010 | 1,604 | 214 | [
"DDInter1101",
"DDInter785"
] | Lumacaftor | Fostamatinib | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Major | 2 | [
[
[
1604,
25,
214
]
],
[
[
1604,
64,
976
],
[
976,
24,
214
]
],
[
[
1604,
25,
861
],
[
861,
63,
214
]
],
[
[
1604,
63,
973
],
[
973,
... | [
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostamatinib"
]
],
[
[
"Lumacaftor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib",
"{... | Lumacaftor may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Lumacaftor may lead to a major life threatening interaction when taken with Ripretinib and Ripretinib may cause a moderate ... |
DB00812 | DB09472 | 998 | 1,383 | [
"DDInter1451",
"DDInter1693"
] | Phenylbutazone | Sodium sulfate | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
998,
24,
1383
]
],
[
[
998,
24,
1613
],
[
1613,
24,
1383
]
],
[
[
998,
25,
1618
],
[
1618,
24,
1383
]
],
[
[
998,
63,
1010
],
[
1010,
... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon b... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Phenylbutazone may lead to a major life threatening interaction when taken with Ca... |
DB00584 | DB08907 | 610 | 1,344 | [
"DDInter638",
"DDInter280"
] | Enalapril | Canagliflozin | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
610,
24,
1344
]
],
[
[
610,
24,
549
],
[
549,
1,
1344
]
],
[
[
610,
6,
4973
],
[
4973,
45,
1344
]
],
[
[
610,
21,
28962
],
[
28962,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Enalapril (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Canagliflozin (Compound)
Enalapril (Compound) causes Hyperkalaemia (Side Effect) an... |
DB00945 | DB01390 | 1,479 | 1,117 | [
"DDInter20",
"DDInter1683"
] | Acetylsalicylic acid | Sodium bicarbonate | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
1479,
24,
1117
]
],
[
[
1479,
21,
28778
],
[
28778,
60,
1117
]
],
[
[
1479,
24,
1220
],
[
1220,
23,
1117
]
],
[
[
1479,
63,
1018
],
[
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphyl... | Acetylsalicylic acid (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sodium bicarbonate (Compound)
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that ... |
DB11963 | DB14881 | 1,045 | 180 | [
"DDInter465",
"DDInter1329"
] | Dacomitinib | Oliceridine | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
1045,
25,
180
]
],
[
[
1045,
63,
401
],
[
401,
24,
180
]
],
[
[
1045,
64,
888
],
[
888,
24,
180
]
],
[
[
1045,
63,
384
],
[
384,
... | [
[
[
"Dacomitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Dacomitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
"Prome... | Dacomitinib may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Dacomitinib may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may c... |
DB00031 | DB00749 | 20 | 59 | [
"DDInter1764",
"DDInter699"
] | Tenecteplase | Etodolac | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
20,
24,
59
]
],
[
[
20,
24,
1018
],
[
1018,
24,
59
]
],
[
[
20,
24,
1039
],
[
1039,
63,
59
]
],
[
[
20,
64,
1578
],
[
1578,
24,
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
],
[... | Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine a... |
DB08886 | DB09045 | 637 | 52 | [
"DDInter126",
"DDInter607"
] | Asparaginase Erwinia chrysanthemi | Dulaglutide | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
637,
24,
52
]
],
[
[
637,
63,
170
],
[
170,
23,
52
]
],
[
[
637,
63,
609
],
[
609,
24,
52
]
],
[
[
637,
24,
1296
],
[
1296,
63,
... | [
[
[
"Asparaginase Erwinia chrysanthemi",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Asparaginase Erwinia chrysanthemi",
"{u} may cause a moderate interaction that could exacerbate diseases when take... | Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate... |
DB01115 | DB09133 | 336 | 1,527 | [
"DDInter1291",
"DDInter965"
] | Nifedipine | Iothalamic acid | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
336,
24,
1527
]
],
[
[
336,
24,
278
],
[
278,
63,
1527
]
],
[
[
336,
40,
84
],
[
84,
24,
1527
]
],
[
[
336,
24,
512
],
[
512,
24... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
],
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid and Iopodic acid may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Nifedipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction... |
DB12001 | DB14975 | 564 | 988 | [
"DDInter7",
"DDInter1949"
] | Abemaciclib | Voxelotor | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
564,
24,
988
]
],
[
[
564,
63,
985
],
[
985,
24,
988
]
],
[
[
564,
25,
676
],
[
676,
63,
988
]
],
[
[
564,
24,
159
],
[
159,
24,... | [
[
[
"Abemaciclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Abemaciclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
],
[
... | Abemaciclib may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Abemaciclib may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may... |
DB00400 | DB01591 | 353 | 667 | [
"DDInter843",
"DDInter1696"
] | Griseofulvin | Solifenacin | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Moderate | 1 | [
[
[
353,
24,
667
]
],
[
[
353,
6,
8374
],
[
8374,
45,
667
]
],
[
[
353,
21,
28722
],
[
28722,
60,
667
]
],
[
[
353,
24,
392
],
[
392,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solifenacin"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Griseofulvin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Solifenacin (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lap... |
DB00945 | DB11560 | 1,479 | 1,678 | [
"DDInter20",
"DDInter1038"
] | Acetylsalicylic acid | Lesinurad | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Moderate | 1 | [
[
[
1479,
24,
1678
]
],
[
[
1479,
63,
522
],
[
522,
24,
1678
]
],
[
[
1479,
24,
877
],
[
877,
63,
1678
]
],
[
[
1479,
25,
1409
],
[
1409,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lesinurad"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirluk... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Lesinurad
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB09054 | DB13007 | 384 | 1,060 | [
"DDInter905",
"DDInter642"
] | Idelalisib | Enfortumab vedotin | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Major | 2 | [
[
[
384,
25,
1060
]
],
[
[
384,
64,
129
],
[
129,
23,
1060
]
],
[
[
384,
25,
913
],
[
913,
23,
1060
]
],
[
[
384,
64,
1593
],
[
1593,
... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Idelalisib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Idelalisib may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause a m... |
DB00361 | DB00877 | 134 | 629 | [
"DDInter1939",
"DDInter1678"
] | Vinorelbine | Sirolimus | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
134,
24,
629
]
],
[
[
134,
6,
4973
],
[
4973,
45,
629
]
],
[
[
134,
7,
9489
],
[
9489,
46,
629
]
],
[
[
134,
18,
7161
],
[
7161,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Vinorelbine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Vinorelbine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Vinorelbine (Compound) upregulates WIF1 (Gene) and WIF1 (Gene) is upregulated by Sirolimus (Compound)
Vinorelbine (Compound) downregulates KLHDC2 (Gene) and KLHDC2 (Gene) is upregulated by Sirolimus (Compound)
Vinorelbine (Compo... |
DB03404 | DB08816 | 765 | 578 | [
"DDInter855",
"DDInter1802"
] | Hemin | Ticagrelor | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
765,
24,
578
]
],
[
[
765,
63,
1578
],
[
1578,
24,
578
]
],
[
[
765,
24,
39
],
[
39,
24,
578
]
],
[
[
765,
24,
1598
],
[
1598,
6... | [
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lepirudin"
],
[
"Lepiru... | Hemin may cause a moderate interaction that could exacerbate diseases when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor
Hemin may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat and Panobinostat may... |
DB00366 | DB01452 | 1,594 | 993 | [
"DDInter600",
"DDInter532"
] | Doxylamine | Diamorphine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Moderate | 1 | [
[
[
1594,
24,
993
]
],
[
[
1594,
63,
421
],
[
421,
40,
993
]
],
[
[
1594,
63,
475
],
[
475,
25,
993
]
],
[
[
1594,
24,
13
],
[
13,
2... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diamorphine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Diamorphine (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening int... |
DB00747 | DB01192 | 1,442 | 560 | [
"DDInter1647",
"DDInter1372"
] | Scopolamine | Oxymorphone | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
1442,
24,
560
]
],
[
[
1442,
63,
828
],
[
828,
1,
560
]
],
[
[
1442,
24,
314
],
[
314,
1,
560
]
],
[
[
1442,
21,
28817
],
[
28817,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxymorphone (Compound... |
DB00431 | DB01362 | 1,503 | 497 | [
"DDInter1072",
"DDInter960"
] | Lindane | Iohexol | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1503,
25,
497
]
],
[
[
1503,
21,
28787
],
[
28787,
60,
497
]
],
[
[
1503,
63,
999
],
[
999,
25,
497
]
],
[
[
1503,
24,
1369
],
[
1369,... | [
[
[
"Lindane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Lindane",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (Compound)",... | Lindane (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iohexol (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when taken with Iohexol
Lindane m... |
DB00501 | DB08827 | 752 | 990 | [
"DDInter380",
"DDInter1085"
] | Cimetidine | Lomitapide | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
752,
24,
990
]
],
[
[
752,
6,
8374
],
[
8374,
45,
990
]
],
[
[
752,
21,
28658
],
[
28658,
60,
990
]
],
[
[
752,
23,
1135
],
[
1135,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Cimetidine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Lomitapide (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol... |
DB00653 | DB01155 | 544 | 872 | [
"DDInter1120",
"DDInter813"
] | Magnesium sulfate | Gemifloxacin | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
544,
24,
872
]
],
[
[
544,
24,
739
],
[
739,
1,
872
]
],
[
[
544,
63,
1467
],
[
1467,
1,
872
]
],
[
[
544,
24,
945
],
[
945,
40,... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxaci... | Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Gemifl... |
DB00006 | DB06822 | 942 | 802 | [
"DDInter217",
"DDInter1812"
] | Bivalirudin | Tinzaparin | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
942,
25,
802
]
],
[
[
942,
23,
944
],
[
944,
62,
802
]
],
[
[
942,
24,
222
],
[
222,
24,
802
]
],
[
[
942,
24,
1427
],
[
1427,
6... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Bivalirudin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",... | Bivalirudin may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutrami... |
DB01206 | DB11627 | 37 | 1,367 | [
"DDInter1086",
"DDInter860"
] | Lomustine | Hepatitis B Vaccine (Recombinant) | An alkylating agent of value against both hematologic malignancies and solid tumors. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
37,
24,
1367
]
],
[
[
37,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
37,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
37,
24,
259
],
[
259,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesl... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Lomustine may lead to a major life threatening interaction when taken with Cladribine an... |
DB00748 | DB00754 | 662 | 157 | [
"DDInter297",
"DDInter696"
] | Carbinoxamine | Ethotoin | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
662,
24,
157
]
],
[
[
662,
24,
759
],
[
759,
40,
157
]
],
[
[
662,
24,
499
],
[
499,
1,
157
]
],
[
[
662,
6,
10215
],
[
10215,
4... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compou... |
DB00005 | DB01610 | 1,057 | 248 | [
"DDInter687",
"DDInter1912"
] | Etanercept | Valganciclovir | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Major | 2 | [
[
[
1057,
25,
248
]
],
[
[
1057,
25,
563
],
[
563,
1,
248
]
],
[
[
1057,
25,
1101
],
[
1101,
24,
248
]
],
[
[
1057,
64,
669
],
[
669,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Valganciclovir"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ganciclovir"
],
[
"Ganciclovir",
... | Etanercept may lead to a major life threatening interaction when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Etanercept may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases whe... |
DB01224 | DB11130 | 623 | 407 | [
"DDInter1553",
"DDInter1344"
] | Quetiapine | Opium | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
623,
24,
407
]
],
[
[
623,
63,
662
],
[
662,
24,
407
]
],
[
[
623,
74,
104
],
[
104,
24,
407
]
],
[
[
623,
24,
849
],
[
849,
24,... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Quetiapine (Compound) resembles Methdilazine (Compound) and Quetiapine may cause a moderate interaction that co... |
DB00912 | DB09082 | 473 | 659 | [
"DDInter1581",
"DDInter1934"
] | Repaglinide | Vilanterol | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
473,
24,
659
]
],
[
[
473,
24,
1220
],
[
1220,
23,
659
]
],
[
[
473,
63,
891
],
[
891,
23,
659
]
],
[
[
473,
24,
927
],
[
927,
6... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone an... |
DB00373 | DB09135 | 461 | 1,211 | [
"DDInter1809",
"DDInter967"
] | Timolol | Ioxilan | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
461,
24,
1211
]
],
[
[
461,
24,
1013
],
[
1013,
63,
1211
]
],
[
[
461,
24,
512
],
[
512,
24,
1211
]
],
[
[
461,
63,
1648
],
[
1648,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tyropanoic acid"
],
[
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid and Tyropanoic acid may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid and Io... |
DB00295 | DB00519 | 475 | 1,638 | [
"DDInter1244",
"DDInter1843"
] | Morphine | Trandolapril | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
475,
24,
1638
]
],
[
[
475,
24,
954
],
[
954,
40,
1638
]
],
[
[
475,
10,
11576
],
[
11576,
44,
1638
]
],
[
[
475,
21,
29305
],
[
29305... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Morphine (Compound) palliates coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Trandolapril (Compound)
Morphine (Compound) ca... |
DB00366 | DB00754 | 1,594 | 157 | [
"DDInter600",
"DDInter696"
] | Doxylamine | Ethotoin | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
1594,
24,
157
]
],
[
[
1594,
24,
759
],
[
759,
40,
157
]
],
[
[
1594,
24,
499
],
[
499,
1,
157
]
],
[
[
1594,
18,
10375
],
[
10375,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compound)
Do... |
DB01082 | DB01329 | 1,448 | 1,458 | [
"DDInter1713",
"DDInter322"
] | Streptomycin | Cefoperazone | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Cefoperazone is a semisynthetic broad-spectrum cephalosporin proposed to be effective against <i>Pseudomonas</i> infections. It is a third-generation antiobiotic agent and it is used in the treatment of various bacterial infections caused by susceptible organisms in the body, including respiratory tract infections, per... | Moderate | 1 | [
[
[
1448,
24,
1458
]
],
[
[
1448,
63,
277
],
[
277,
1,
1458
]
],
[
[
1448,
24,
1402
],
[
1402,
40,
1458
]
],
[
[
1448,
24,
1227
],
[
1227,... | [
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefoperazone"
]
],
[
[
"Streptomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefmetazole"
],
... | Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefmetazole and Cefmetazole (Compound) resembles Cefoperazone (Compound)
Streptomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefotetan and Cefotetan (Compound) resembles Cefoperazone (Co... |
DB00792 | DB06016 | 832 | 1,508 | [
"DDInter1878",
"DDInter300"
] | Tripelennamine | Cariprazine | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
832,
24,
1508
]
],
[
[
832,
63,
1242
],
[
1242,
24,
1508
]
],
[
[
832,
24,
1507
],
[
1507,
24,
1508
]
],
[
[
832,
35,
272
],
[
272,
... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
],... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomine ... |
DB00774 | DB11348 | 1,577 | 1,065 | [
"DDInter889",
"DDInter279"
] | Hydroflumethiazide | Calcium Phosphate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
1577,
24,
1065
]
],
[
[
1577,
62,
1620
],
[
1620,
24,
1065
]
],
[
[
1577,
1,
359
],
[
359,
24,
1065
]
],
[
[
1577,
40,
178
],
[
178,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tetrac... | Hydroflumethiazide may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound) and Chlorothiazide may cause ... |
DB00344 | DB00470 | 1,302 | 530 | [
"DDInter1543",
"DDInter601"
] | Protriptyline | Dronabinol | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Moderate | 1 | [
[
[
1302,
24,
530
]
],
[
[
1302,
24,
1614
],
[
1614,
40,
530
]
],
[
[
1302,
6,
4973
],
[
4973,
45,
530
]
],
[
[
1302,
21,
28708
],
[
28708... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
],
... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone (Compound) resembles Dronabinol (Compound)
Protriptyline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dronabinol (Compound)
Protriptyline (Compound) causes Malaise (Side Effect) and Malaise ... |
DB06077 | DB06691 | 879 | 849 | [
"DDInter1102",
"DDInter1155"
] | Lumateperone | Mepyramine | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
879,
24,
849
]
],
[
[
879,
63,
1594
],
[
1594,
24,
849
]
],
[
[
879,
24,
407
],
[
407,
63,
849
]
],
[
[
879,
64,
1311
],
[
1311,
... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium m... |
DB00960 | DB00983 | 887 | 480 | [
"DDInter1471",
"DDInter776"
] | Pindolol | Formoterol | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Major | 2 | [
[
[
887,
25,
480
]
],
[
[
887,
24,
1148
],
[
1148,
63,
480
]
],
[
[
887,
6,
1704
],
[
1704,
45,
480
]
],
[
[
887,
21,
28963
],
[
28963,
... | [
[
[
"Pindolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Formoterol"
]
],
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Isoprenaline... | Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Pindolol (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Formoterol (Compound)
Pindolol (Compound) ... |
DB08826 | DB09330 | 1,292 | 985 | [
"DDInter489",
"DDInter1352"
] | Deferiprone | Osimertinib | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1292,
25,
985
]
],
[
[
1292,
64,
168
],
[
168,
23,
985
]
],
[
[
1292,
64,
134
],
[
134,
24,
985
]
],
[
[
1292,
25,
1598
],
[
1598,
... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
"{u... | Deferiprone may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Deferiprone may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may cause a moderate i... |
DB06702 | DB11130 | 573 | 407 | [
"DDInter731",
"DDInter1344"
] | Fesoterodine | Opium | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
573,
24,
407
]
],
[
[
573,
63,
662
],
[
662,
24,
407
]
],
[
[
573,
24,
412
],
[
412,
24,
407
]
],
[
[
573,
40,
211
],
[
211,
24,... | [
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Fesoterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Fesoterodine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline and ... |
DB00069 | DB06414 | 367 | 655 | [
"DDInter946",
"DDInter703"
] | Interferon alfacon-1 | Etravirine | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
367,
24,
655
]
],
[
[
367,
25,
1101
],
[
1101,
23,
655
]
],
[
[
367,
24,
168
],
[
168,
23,
655
]
],
[
[
367,
63,
1057
],
[
1057,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
... | Interferon alfacon-1 may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Etravirine
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bor... |
DB00353 | DB09280 | 588 | 1,604 | [
"DDInter1187",
"DDInter1101"
] | Methylergometrine | Lumacaftor | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
588,
24,
1604
]
],
[
[
588,
40,
628
],
[
628,
24,
1604
]
],
[
[
588,
24,
522
],
[
522,
24,
1604
]
],
[
[
588,
24,
985
],
[
985,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Methylergometrine",
"{u} (Compound) resembles {v} (Compound)",
"Ergometrine"
],
[
"Ergometrine",
"{u} may... | Methylergometrine (Compound) resembles Ergometrine (Compound) and Ergometrine may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate inte... |
DB00078 | DB03619 | 1,172 | 557 | [
"DDInter898",
"DDInter501"
] | Ibritumomab tiuxetan | Deoxycholic acid | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Moderate | 1 | [
[
[
1172,
24,
557
]
],
[
[
1172,
25,
1479
],
[
1479,
24,
557
]
],
[
[
1172,
25,
405
],
[
405,
63,
557
]
],
[
[
1172,
64,
1255
],
[
1255,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetylsalicylic ... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Acala... |
DB00615 | DB12130 | 690 | 1,017 | [
"DDInter1589",
"DDInter1094"
] | Rifabutin | Lorlatinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
690,
25,
1017
]
],
[
[
690,
62,
608
],
[
608,
23,
1017
]
],
[
[
690,
63,
590
],
[
590,
24,
1017
]
],
[
[
690,
24,
175
],
[
175,
... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Rifabutin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
"Lidocaine",
... | Rifabutin may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexami... |
DB06589 | DB12245 | 1,250 | 823 | [
"DDInter1400",
"DDInter1863"
] | Pazopanib | Triclabendazole | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
1250,
24,
823
]
],
[
[
1250,
62,
1247
],
[
1247,
23,
823
]
],
[
[
1250,
24,
1612
],
[
1612,
24,
823
]
],
[
[
1250,
63,
1010
],
[
1010,... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavi... |
DB00241 | DB00748 | 288 | 662 | [
"DDInter257",
"DDInter297"
] | Butalbital | Carbinoxamine | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
288,
24,
662
]
],
[
[
288,
24,
1594
],
[
1594,
24,
662
]
],
[
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288,
24,
407
],
[
407,
63,
662
]
],
[
[
288,
25,
475
],
[
475,
2... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium ma... |
DB05239 | DB11757 | 866 | 960 | [
"DDInter425",
"DDInter994"
] | Cobimetinib | Istradefylline | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Moderate | 1 | [
[
[
866,
24,
960
]
],
[
[
866,
63,
86
],
[
86,
24,
960
]
],
[
[
866,
64,
1419
],
[
1419,
24,
960
]
],
[
[
866,
24,
1374
],
[
1374,
2... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Istradefylline"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
],
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Miconazole and Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Istradefylline
Cobimetinib may lead to a major life threatening interaction when taken with Imatinib and Imatinib may caus... |
DB00790 | DB09146 | 664 | 489 | [
"DDInter1431",
"DDInter978"
] | Perindopril | Iron sucrose | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
664,
24,
489
]
],
[
[
664,
40,
1058
],
[
1058,
24,
489
]
],
[
[
664,
1,
954
],
[
954,
24,
489
]
],
[
[
664,
40,
1058
],
[
1058,
... | [
[
[
"Perindopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Perindopril",
"{u} (Compound) resembles {v} (Compound)",
"Moexipril"
],
[
"Moexipril",
"{u} may cause a moder... | Perindopril (Compound) resembles Moexipril (Compound) and Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Perindopril (Compound) resembles Quinapril (Compound) and Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Iron sucros... |
DB06824 | DB11110 | 29 | 603 | [
"DDInter1864",
"DDInter1115"
] | Triethylenetetramine | Magnesium citrate | Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, [spermidine] and [spermine]. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925. Initially approved... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
29,
24,
603
]
],
[
[
29,
24,
853
],
[
853,
24,
603
]
],
[
[
29,
23,
1193
],
[
1193,
62,
167
],
[
167,
24,
603
]
],
[
[
29,
24,
... | [
[
[
"Triethylenetetramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Triethylenetetramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Triethylenetetramine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride and Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Triethylenetetramine may cause a minor interaction that can limit clinical effe... |
DB00011 | DB06273 | 1,451 | 980 | [
"DDInter944",
"DDInter1824"
] | Interferon alfa-n1 | Tocilizumab | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1451,
24,
980
]
],
[
[
1451,
25,
139
],
[
139,
24,
980
]
],
[
[
1451,
24,
309
],
[
309,
24,
980
]
],
[
[
1451,
24,
110
],
[
110,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Interferon alfa-n1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
... | Interferon alfa-n1 may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixa... |
DB01124 | DB14751 | 1,411 | 388 | [
"DDInter1828",
"DDInter1132"
] | Tolbutamide | Mecasermin rinfabate | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Mecasermin rinfabate is approved for severe primary insulin-like growth factor (IGF) deficiency or in patients with GH gene deletion who have developed antibodies to growth hormone (GH). Mecasermin rinfabate is similar to in that both drugs contain recombinant DNA origin insulin-like growth factor 1 (IGF-1). Mecasermin... | Moderate | 1 | [
[
[
1411,
24,
388
]
],
[
[
1411,
63,
1144
],
[
1144,
24,
388
]
],
[
[
1411,
1,
959
],
[
959,
24,
388
]
],
[
[
1411,
24,
1296
],
[
1296,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mecasermin rinfabate"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Mecasermin rinfabate
Tolbutamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a moderate interactio... |
DB00450 | DB11186 | 78 | 1,609 | [
"DDInter603",
"DDInter1427"
] | Droperidol | Pentoxyverine | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
78,
24,
1609
]
],
[
[
78,
24,
104
],
[
104,
24,
1609
]
],
[
[
78,
63,
999
],
[
999,
24,
1609
]
],
[
[
78,
40,
1568
],
[
1568,
24... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazi... |
DB00404 | DB06372 | 523 | 259 | [
"DDInter54",
"DDInter1594"
] | Alprazolam | Rilonacept | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
523,
24,
259
]
],
[
[
523,
24,
1619
],
[
1619,
63,
259
]
],
[
[
523,
1,
1565
],
[
1565,
24,
259
]
],
[
[
523,
23,
1573
],
[
1573,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Alprazolam (Compound) resembles Clonazepam (Compound) and Clonazepam may cause a moderate interaction that could e... |
DB00427 | DB01142 | 1,233 | 1,264 | [
"DDInter1879",
"DDInter593"
] | Triprolidine | Doxepin | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1233,
24,
1264
]
],
[
[
1233,
63,
508
],
[
508,
24,
1264
]
],
[
[
1233,
24,
401
],
[
401,
24,
1264
]
],
[
[
1233,
24,
649
],
[
649,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
],
[
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Prome... |
DB01191 | DB06655 | 1,039 | 5 | [
"DDInter518",
"DDInter1077"
] | Dexfenfluramine | Liraglutide | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1039,
24,
5
]
],
[
[
1039,
63,
245
],
[
245,
24,
5
]
],
[
[
1039,
64,
73
],
[
73,
24,
5
]
],
[
[
1039,
25,
1529
],
[
1529,
24,
... | [
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
... | Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Dexfenfluramine may lead to a major life threatening interaction when taken with Phentermine and Phenter... |
DB00238 | DB01097 | 188 | 1,377 | [
"DDInter1285",
"DDInter1033"
] | Nevirapine | Leflunomide | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
188,
25,
1377
]
],
[
[
188,
6,
6017
],
[
6017,
45,
1377
]
],
[
[
188,
21,
29062
],
[
29062,
60,
1377
]
],
[
[
188,
24,
126
],
[
126,
... | [
[
[
"Nevirapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Leflun... | Nevirapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Leflunomide (Compound)
Nevirapine (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and ... |
DB01611 | DB08871 | 1,487 | 36 | [
"DDInter893",
"DDInter666"
] | Hydroxychloroquine | Eribulin | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1487,
25,
36
]
],
[
[
1487,
63,
122
],
[
122,
23,
36
]
],
[
[
1487,
62,
1247
],
[
1247,
23,
36
]
],
[
[
1487,
64,
519
],
[
519,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
],
[
... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxaz... |
DB00795 | DB12267 | 50 | 1,476 | [
"DDInter1725",
"DDInter233"
] | Sulfasalazine | Brigatinib | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
50,
24,
1476
]
],
[
[
50,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
50,
25,
629
],
[
629,
24,
1476
]
],
[
[
50,
63,
176
],
[
176,
24... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
... | Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Sulfasalazine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may ca... |
DB00850 | DB01001 | 1,630 | 688 | [
"DDInter1432",
"DDInter1632"
] | Perphenazine | Salbutamol | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1630,
24,
688
]
],
[
[
1630,
63,
874
],
[
874,
24,
688
]
],
[
[
1630,
24,
455
],
[
455,
24,
688
]
],
[
[
1630,
24,
1148
],
[
1148,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and ... |
DB01098 | DB08880 | 14 | 1,510 | [
"DDInter1622",
"DDInter1771"
] | Rosuvastatin | Teriflunomide | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
14,
25,
1510
]
],
[
[
14,
24,
1033
],
[
1033,
63,
1510
]
],
[
[
14,
62,
303
],
[
303,
24,
1510
]
],
[
[
14,
24,
1191
],
[
1191,
... | [
[
[
"Rosuvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
"Alpe... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Rosuvastatin may cause a minor interaction that can limit clinical effects when taken with Medroxyprogesteron... |
DB00344 | DB00981 | 1,302 | 1,528 | [
"DDInter1543",
"DDInter1463"
] | Protriptyline | Physostigmine (ophthalmic) | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Moderate | 1 | [
[
[
1302,
24,
1528
]
],
[
[
1302,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
1302,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
1302,
24,
543
],
[
5... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Protriptyline",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effe... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Protriptyline (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken... |
DB01044 | DB06603 | 246 | 39 | [
"DDInter809",
"DDInter1387"
] | Gatifloxacin | Panobinostat | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
246,
25,
39
]
],
[
[
246,
62,
112
],
[
112,
23,
39
]
],
[
[
246,
63,
455
],
[
455,
24,
39
]
],
[
[
246,
62,
869
],
[
869,
24,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Gatifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Gatifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol an... |
DB00850 | DB08897 | 1,630 | 1,429 | [
"DDInter1432",
"DDInter22"
] | Perphenazine | Aclidinium | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
1630,
24,
1429
]
],
[
[
1630,
63,
352
],
[
352,
24,
1429
]
],
[
[
1630,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
1630,
21,
28817
],
[
288... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepen... |
DB05679 | DB08868 | 1,683 | 1,011 | [
"DDInter1907",
"DDInter737"
] | Ustekinumab | Fingolimod | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1683,
25,
1011
]
],
[
[
1683,
24,
748
],
[
748,
63,
1011
]
],
[
[
1683,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
1683,
63,
1081
],
[
1081... | [
[
[
"Ustekinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
[
"Ant... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Denosumab... |
DB00701 | DB06655 | 1,091 | 5 | [
"DDInter90",
"DDInter1077"
] | Amprenavir | Liraglutide | Amprenavir is a protease inhibitor used to treat HIV infection. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1091,
24,
5
]
],
[
[
1091,
63,
353
],
[
353,
23,
5
]
],
[
[
1091,
24,
1142
],
[
1142,
24,
5
]
],
[
[
1091,
63,
870
],
[
870,
24,... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
],
[... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and Orlis... |
DB00877 | DB00909 | 629 | 306 | [
"DDInter1678",
"DDInter1971"
] | Sirolimus | Zonisamide | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Moderate | 1 | [
[
[
629,
24,
306
]
],
[
[
629,
7,
8018
],
[
8018,
45,
306
]
],
[
[
629,
6,
8374
],
[
8374,
45,
306
]
],
[
[
629,
7,
5137
],
[
5137,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zonisamide"
]
],
[
[
"Sirolimus",
"{u} (Compound) upregulates {v} (Gene)",
"SCN1B"
],
[
"SCN1B",
"{u} (Gene) is bound by {v} (Compound)... | Sirolimus (Compound) upregulates SCN1B (Gene) and SCN1B (Gene) is bound by Zonisamide (Compound)
Sirolimus (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zonisamide (Compound)
Sirolimus (Compound) upregulates KDM5A (Gene) and KDM5A (Gene) is upregulated by Zonisamide (Compound)
Sirolimus (Compound) downre... |
DB05812 | DB14730 | 1,374 | 1,412 | [
"DDInter8",
"DDInter264"
] | Abiraterone | Calaspargase pegol | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1374,
24,
1412
]
],
[
[
1374,
24,
159
],
[
159,
24,
1412
]
],
[
[
1374,
63,
322
],
[
322,
24,
1412
]
],
[
[
1374,
25,
868
],
[
868,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
... | Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Epiru... |
DB01028 | DB11130 | 1,332 | 407 | [
"DDInter1179",
"DDInter1344"
] | Methoxyflurane | Opium | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1332,
24,
407
]
],
[
[
1332,
63,
475
],
[
475,
24,
407
]
],
[
[
1332,
25,
497
],
[
497,
25,
407
]
],
[
[
1332,
63,
475
],
[
475,
... | [
[
[
"Methoxyflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Methoxyflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Methoxyflurane may lead to a major life threatening interaction when taken with Iohexol and Iohexol may lead to a maj... |
DB00518 | DB01263 | 510 | 859 | [
"DDInter35",
"DDInter1494"
] | Albendazole | Posaconazole | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
510,
24,
859
]
],
[
[
510,
6,
4973
],
[
4973,
45,
859
]
],
[
[
510,
21,
28762
],
[
28762,
60,
859
]
],
[
[
510,
63,
1101
],
[
1101,
... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Albendazole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Albendazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Albendazole (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and B... |
DB06282 | DB14509 | 516 | 1,399 | [
"DDInter1053",
"DDInter1081"
] | Levocetirizine | Lithium carbonate | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
516,
24,
1399
]
],
[
[
516,
63,
820
],
[
820,
24,
1399
]
],
[
[
516,
24,
407
],
[
407,
24,
1399
]
],
[
[
516,
62,
1031
],
[
1031,
... | [
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Levocetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"... | Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Levocetirizine may cause a moderate interaction that could exacerbate diseases when taken with Opiu... |
DB00877 | DB00907 | 629 | 290 | [
"DDInter1678",
"DDInter427"
] | Sirolimus | Cocaine (topical) | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
629,
24,
290
]
],
[
[
629,
6,
21998
],
[
21998,
45,
290
]
],
[
[
629,
21,
28741
],
[
28741,
60,
290
]
],
[
[
629,
64,
1622
],
[
1622,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Sirolimus",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by {v}... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Sirolimus (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Cocaine (Compound)
Sirolimus (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Cocaine (Compound)
Si... |
DB01021 | DB01278 | 674 | 1,021 | [
"DDInter1861",
"DDInter1506"
] | Trichlormethiazide | Pramlintide | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
674,
24,
1021
]
],
[
[
674,
24,
708
],
[
708,
63,
1021
]
],
[
[
674,
62,
1507
],
[
1507,
24,
1021
]
],
[
[
674,
63,
891
],
[
891,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotro... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with ... |
DB00687 | DB09263 | 870 | 1,436 | [
"DDInter747",
"DDInter1399"
] | Fludrocortisone | Patiromer | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
870,
24,
1436
]
],
[
[
870,
1,
1220
],
[
1220,
24,
1436
]
],
[
[
870,
63,
1645
],
[
1645,
24,
1436
]
],
[
[
870,
24,
603
],
[
603,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexamethasone",
"{u} may ... | Fludrocortisone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interacti... |
DB09101 | DB09104 | 70 | 286 | [
"DDInter633",
"DDInter1118"
] | Elvitegravir | Magnesium hydroxide | Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome ... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
70,
24,
286
]
],
[
[
70,
63,
868
],
[
868,
24,
286
]
],
[
[
70,
64,
129
],
[
129,
24,
286
]
],
[
[
70,
24,
982
],
[
982,
63,
... | [
[
[
"Elvitegravir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Elvitegravir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
... | Elvitegravir may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide
Elvitegravir may lead to a major life threatening interaction when taken with Enzalutamide and Enza... |
DB01232 | DB09564 | 1,327 | 1,296 | [
"DDInter1640",
"DDInter930"
] | Saquinavir | Insulin degludec | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1327,
24,
1296
]
],
[
[
1327,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1327,
24,
659
],
[
659,
24,
1296
]
],
[
[
1327,
25,
1151
],
[
1151... | [
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Saquinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Saquinavir may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol an... |
DB00414 | DB01324 | 590 | 178 | [
"DDInter16",
"DDInter1490"
] | Acetohexamide | Polythiazide | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
590,
24,
178
]
],
[
[
590,
24,
504
],
[
504,
40,
178
]
],
[
[
590,
24,
52
],
[
52,
63,
178
]
],
[
[
590,
24,
848
],
[
848,
24,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a mod... |
DB01155 | DB01246 | 872 | 820 | [
"DDInter813",
"DDInter45"
] | Gemifloxacin | Alimemazine | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
872,
24,
820
]
],
[
[
872,
63,
401
],
[
401,
24,
820
]
],
[
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872,
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28662
],
[
28662,
60,
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]
],
[
[
872,
24,
286
],
[
286,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Gemifloxacin (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Alimemazine (Co... |
DB01110 | DB14840 | 86 | 861 | [
"DDInter1209",
"DDInter1601"
] | Miconazole | Ripretinib | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
86,
24,
861
]
],
[
[
86,
24,
351
],
[
351,
24,
861
]
],
[
[
86,
25,
1670
],
[
1670,
24,
861
]
],
[
[
86,
62,
1101
],
[
1101,
24,... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Miconazole may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause ... |
DB00476 | DB01050 | 109 | 848 | [
"DDInter608",
"DDInter900"
] | Duloxetine | Ibuprofen | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
109,
24,
848
]
],
[
[
109,
25,
1053
],
[
1053,
1,
848
]
],
[
[
109,
21,
28773
],
[
28773,
60,
848
]
],
[
[
109,
24,
752
],
[
752,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Duloxetine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Procarbazine"
],
[
"Procarbaz... | Duloxetine may lead to a major life threatening interaction when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Duloxetine (Compound) causes Urethral disorder (Side Effect) and Urethral disorder (Side Effect) is caused by Ibuprofen (Compound)
Duloxetine may cause a moderate interacti... |
DB01166 | DB12332 | 477 | 1,619 | [
"DDInter379",
"DDInter1626"
] | Cilostazol | Rucaparib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
477,
24,
1619
]
],
[
[
477,
63,
222
],
[
222,
23,
1619
]
],
[
[
477,
62,
112
],
[
112,
23,
1619
]
],
[
[
477,
63,
87
],
[
87,
24... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Cilostazol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00590 | DB08907 | 1,433 | 1,344 | [
"DDInter592",
"DDInter280"
] | Doxazosin | Canagliflozin | Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include [Prazosin], [Terazosin], [Tamsulosin], and [Alfuzosin]. Because of its long-lasting effects, doxazosin can be administered once a day. It is marketed by Pfi... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1433,
24,
1344
]
],
[
[
1433,
24,
549
],
[
549,
1,
1344
]
],
[
[
1433,
6,
4973
],
[
4973,
45,
1344
]
],
[
[
1433,
21,
28681
],
[
28681... | [
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Doxazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Doxazosin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Doxazosin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Canagliflozin (Compound)
Doxazosin (Compound) causes Hypersensitivity (Side Effect)... |
DB00916 | DB09473 | 112 | 884 | [
"DDInter1202",
"DDInter918"
] | Metronidazole | Indium In-111 oxyquinoline | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Indium In 111 oxyquinoline (oxine) is a diagnostic radiopharmaceutical intended for radiolabeling of autologous leukocytes. It is composed of a 3:1 saturated complex of In-111 isotope and oxyquinoline. Indium-111 decays by isomeric transition and electron capture to cadmium-111, emitting a gamma ray that can be detecte... | Moderate | 1 | [
[
[
112,
24,
884
]
],
[
[
112,
63,
597
],
[
597,
24,
884
]
],
[
[
112,
24,
148
],
[
148,
63,
884
]
],
[
[
112,
23,
609
],
[
609,
24,... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indium In-111 oxyquinoline"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlor... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Indium In-111 oxyquinoline
Metronidazole may cause a moderate interaction that could exacerbate diseases when ... |
DB00444 | DB09115 | 63 | 505 | [
"DDInter1765",
"DDInter559"
] | Teniposide | Diiodohydroxyquinoline | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Diiodohydroxyquinoline, also known as uidoquinol and iodoquinol, is a quinoline derivative that can be used in the treatment of amoebiasis. The exact mechanism of action is unknown. Iodoquinol is not currently available in any FDA-approved products. | Moderate | 1 | [
[
[
63,
24,
505
]
],
[
[
63,
24,
1593
],
[
1593,
24,
505
]
],
[
[
63,
25,
908
],
[
908,
24,
505
]
],
[
[
63,
63,
168
],
[
168,
24,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diiodohydroxyquinoline"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline
Teniposide may lead to a major life threatening interaction when taken with Golimumab and Golimumab ... |
DB09039 | DB11730 | 1,670 | 351 | [
"DDInter629",
"DDInter1588"
] | Eliglustat | Ribociclib | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1670,
25,
351
]
],
[
[
1670,
64,
271
],
[
271,
23,
351
]
],
[
[
1670,
25,
283
],
[
283,
62,
351
]
],
[
[
1670,
62,
479
],
[
479,
... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
"{u} m... | Eliglustat may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Eliglustat may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interacti... |
DB00582 | DB01110 | 1,622 | 86 | [
"DDInter1946",
"DDInter1209"
] | Voriconazole | Miconazole | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
1622,
24,
86
]
],
[
[
1622,
6,
10215
],
[
10215,
45,
86
]
],
[
[
1622,
54,
19182
],
[
19182,
15,
86
]
],
[
[
1622,
21,
29122
],
[
2912... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compo... | Voriconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Miconazole (Compound)
Voriconazole (Compound) is included by Azoles (Pharmacologic Class) and Azoles (Pharmacologic Class) includes Miconazole (Compound)
Voriconazole (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder... |
DB09082 | DB09352 | 659 | 373 | [
"DDInter1934",
"DDInter892"
] | Vilanterol | Hydroxyamphetamine (ophthalmic) | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | 4-(2-aminopropyl)phenol is a member of amphetamines. | Moderate | 1 | [
[
[
659,
24,
373
]
],
[
[
659,
63,
480
],
[
480,
24,
373
]
],
[
[
659,
63,
480
],
[
480,
24,
688
],
[
688,
24,
373
]
],
[
[
659,
63,... | [
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyamphetamine"
]
],
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyamphetamine
Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyamphet... |
DB00609 | DB00773 | 595 | 896 | [
"DDInter694",
"DDInter702"
] | Ethionamide | Etoposide | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
595,
24,
896
]
],
[
[
595,
21,
28681
],
[
28681,
60,
896
]
],
[
[
595,
63,
147
],
[
147,
23,
896
]
],
[
[
595,
24,
310
],
[
310,
... | [
[
[
"Ethionamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Ethionamide",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side ... | Ethionamide (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Etoposide (Compound)
Ethionamide may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when tak... |
DB00800 | DB06292 | 572 | 549 | [
"DDInter720",
"DDInter474"
] | Fenoldopam | Dapagliflozin | A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
572,
24,
549
]
],
[
[
572,
24,
1344
],
[
1344,
40,
549
]
],
[
[
572,
21,
28882
],
[
28882,
60,
549
]
],
[
[
572,
24,
401
],
[
401,
... | [
[
[
"Fenoldopam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Fenoldopam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
],
... | Fenoldopam may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Fenoldopam (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dapagliflozin (Compound... |
DB00358 | DB06589 | 1,010 | 1,250 | [
"DDInter1140",
"DDInter1400"
] | Mefloquine | Pazopanib | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1010,
24,
1250
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
1250
]
],
[
[
1010,
7,
4649
],
[
4649,
46,
1250
]
],
[
[
1010,
21,
28658
],
[
286... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Pazopanib (Compound)
Mefloquine (Compound) upregulates CPVL (Gene) and CPVL (Gene) is upregulated by Pazopanib (Compound)
Mefloquine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Mefloquine may ... |
DB00197 | DB06817 | 1,324 | 809 | [
"DDInter1881",
"DDInter1563"
] | Troglitazone | Raltegravir | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Raltegravir is an antiretroviral drug produced by Merck & Co., used to treat HIV infection. It received approval by the U.S. Food and Drug Administration (FDA) on 12 October 2007, the first of a new class of HIV drugs, the integrase inhibitors, to receive such approval. | Minor | 0 | [
[
[
1324,
23,
809
]
],
[
[
1324,
24,
478
],
[
478,
23,
809
]
],
[
[
1324,
24,
1017
],
[
1017,
63,
809
]
],
[
[
1324,
24,
1142
],
[
1142,
... | [
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Raltegravir"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a minor interaction that can limit clinical effects when taken with Raltegravir
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorla... |
DB01024 | DB06723 | 1,096 | 115 | [
"DDInter1252",
"DDInter58"
] | Mycophenolic acid | Aluminum hydroxide | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
1096,
24,
115
]
],
[
[
1096,
21,
28643
],
[
28643,
60,
115
]
],
[
[
1096,
63,
954
],
[
954,
23,
115
]
],
[
[
1096,
63,
1176
],
[
1176,... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Mycophenolic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u}... | Mycophenolic acid (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril may cause a minor interaction that can limit clinical effects when ... |
DB01229 | DB09276 | 973 | 381 | [
"DDInter1378",
"DDInter1682"
] | Paclitaxel (protein-bound) | Sodium aurothiomalate | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
973,
24,
381
]
],
[
[
973,
24,
1683
],
[
1683,
24,
381
]
],
[
[
973,
63,
491
],
[
491,
24,
381
]
],
[
[
973,
25,
375
],
[
375,
2... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium a... |
DB00450 | DB00836 | 78 | 543 | [
"DDInter603",
"DDInter1088"
] | Droperidol | Loperamide | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
78,
24,
543
]
],
[
[
78,
24,
1118
],
[
1118,
40,
543
]
],
[
[
78,
24,
649
],
[
649,
1,
543
]
],
[
[
78,
25,
888
],
[
888,
24,
... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
],
[
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Difenoxin and Difenoxin (Compound) resembles Loperamide (Compound)
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Loperamide (Compound)
Dr... |
DB00418 | DB11986 | 536 | 484 | [
"DDInter1650",
"DDInter648"
] | Secobarbital | Entrectinib | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
536,
24,
484
]
],
[
[
536,
24,
112
],
[
112,
23,
484
]
],
[
[
536,
24,
466
],
[
466,
62,
484
]
],
[
[
536,
24,
1320
],
[
1320,
2... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide... |
DB00884 | DB01575 | 1,008 | 1,054 | [
"DDInter1604",
"DDInter1005"
] | Risedronic acid | Kaolin | Risedronic acid is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Moderate | 1 | [
[
[
1008,
24,
1054
]
],
[
[
1008,
40,
1485
],
[
1485,
24,
1054
]
],
[
[
1008,
40,
1485
],
[
1485,
1,
1199
],
[
1199,
24,
1054
]
],
[
[
100... | [
[
[
"Risedronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kaolin"
]
],
[
[
"Risedronic acid",
"{u} (Compound) resembles {v} (Compound)",
"Alendronic acid"
],
[
"Alendronic acid",
"{u} may... | Risedronic acid (Compound) resembles Alendronic acid (Compound) and Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Kaolin
Risedronic acid (Compound) resembles Alendronic acid (Compound) and Alendronic acid (Compound) resembles Ibandronate (Compound) and Ibandronate may c... |
DB11689 | DB12500 | 321 | 283 | [
"DDInter1659",
"DDInter714"
] | Selumetinib | Fedratinib | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
321,
25,
283
]
],
[
[
321,
25,
351
],
[
351,
23,
283
]
],
[
[
321,
64,
1593
],
[
1593,
23,
283
]
],
[
[
321,
64,
1419
],
[
1419,
... | [
[
[
"Selumetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Selumetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",
"{u}... | Selumetinib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Selumetinib may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a minor interac... |
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