drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00065 | DB00075 | 581 | 541 | [
"DDInter923",
"DDInter1250"
] | Infliximab | Muromonab | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Major | 2 | [
[
[
581,
25,
541
]
],
[
[
581,
23,
1193
],
[
1193,
62,
541
]
],
[
[
581,
25,
270
],
[
270,
63,
541
]
],
[
[
581,
24,
58
],
[
58,
63,... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Muromonab"
]
],
[
[
"Infliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluc... | Infliximab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Muromonab
Infliximab may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may c... |
DB00618 | DB11248 | 1,572 | 1,193 | [
"DDInter498",
"DDInter1965"
] | Demeclocycline | Zinc gluconate | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Moderate | 1 | [
[
[
1572,
24,
1193
]
],
[
[
1572,
24,
1096
],
[
1096,
23,
1193
]
],
[
[
1572,
24,
260
],
[
260,
62,
1193
]
],
[
[
1572,
40,
1620
],
[
1620... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic ac... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00092 | DB01097 | 58 | 1,377 | [
"DDInter40",
"DDInter1033"
] | Alefacept | Leflunomide | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
58,
25,
1377
]
],
[
[
58,
23,
1461
],
[
1461,
23,
1377
]
],
[
[
58,
23,
1193
],
[
1193,
62,
1377
]
],
[
[
58,
24,
949
],
[
949,
... | [
[
[
"Alefacept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Leflunomide
Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc glucon... |
DB00397 | DB00472 | 1,466 | 758 | [
"DDInter1458",
"DDInter758"
] | Phenylpropanolamine | Fluoxetine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Major | 2 | [
[
[
1466,
25,
758
]
],
[
[
1466,
63,
847
],
[
847,
1,
758
]
],
[
[
1466,
25,
109
],
[
109,
40,
758
]
],
[
[
1466,
1,
838
],
[
838,
1... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluoxetine"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Fluoxetine (Compound)
Phenylpropanolamine may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine (Compound) resembles Fluoxetine (Compo... |
DB00086 | DB01240 | 1,167 | 885 | [
"DDInter1712",
"DDInter657"
] | Streptokinase | Epoprostenol | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1167,
24,
885
]
],
[
[
1167,
24,
1061
],
[
1061,
1,
885
]
],
[
[
1167,
23,
539
],
[
539,
62,
885
]
],
[
[
1167,
24,
1512
],
[
1512,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Streptokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that ca... |
DB00619 | DB12457 | 1,419 | 1,180 | [
"DDInter909",
"DDInter1598"
] | Imatinib | Rimegepant | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Rimegepant is an oral antagonist of the CGRP receptor developed by Biohaven Pharmaceuticals. It received FDA approval on February 27, 2020 for the acute treatment migraine headache, and was subsequently approved by the European Commission in April 2022 for both the treatment and prevention of migraines. While several p... | Moderate | 1 | [
[
[
1419,
24,
1180
]
],
[
[
1419,
24,
1619
],
[
1619,
24,
1180
]
],
[
[
1419,
24,
1501
],
[
1501,
63,
1180
]
],
[
[
1419,
25,
927
],
[
927... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rimegepant"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rimegepant
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib and Enasidenib m... |
DB00261 | DB00963 | 702 | 1,263 | [
"DDInter93",
"DDInter241"
] | Anagrelide | Bromfenac | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
702,
24,
1263
]
],
[
[
702,
24,
935
],
[
935,
40,
1263
]
],
[
[
702,
24,
1512
],
[
1512,
24,
1263
]
],
[
[
702,
18,
9205
],
[
9205,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could ... |
DB00341 | DB00372 | 1,242 | 999 | [
"DDInter343",
"DDInter1793"
] | Cetirizine | Thiethylperazine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
1242,
24,
999
]
],
[
[
1242,
63,
784
],
[
784,
24,
999
]
],
[
[
1242,
24,
1614
],
[
1614,
63,
999
]
],
[
[
1242,
24,
695
],
[
695,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pregabalin"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Pregabalin and Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Na... |
DB00209 | DB01192 | 352 | 560 | [
"DDInter1886",
"DDInter1372"
] | Trospium | Oxymorphone | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
352,
24,
560
]
],
[
[
352,
24,
828
],
[
828,
1,
560
]
],
[
[
352,
6,
12523
],
[
12523,
45,
560
]
],
[
[
352,
21,
28817
],
[
28817,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Oxymorphone (Compound)
Trospium (Compound) causes Vision blurred (Side Effect) and Vision blu... |
DB00242 | DB06688 | 1,064 | 1,430 | [
"DDInter392",
"DDInter1677"
] | Cladribine | Sipuleucel-T | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Major | 2 | [
[
[
1064,
25,
1430
]
],
[
[
1064,
25,
175
],
[
175,
24,
1430
]
],
[
[
1064,
24,
869
],
[
869,
24,
1430
]
],
[
[
1064,
25,
676
],
[
676,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone",
... | Cladribine may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Topotecan and Topotecan may ... |
DB01172 | DB09156 | 416 | 777 | [
"DDInter1004",
"DDInter964"
] | Kanamycin | Iopromide | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Major | 2 | [
[
[
416,
25,
777
]
],
[
[
416,
64,
1028
],
[
1028,
24,
777
]
],
[
[
416,
23,
699
],
[
699,
24,
777
]
],
[
[
416,
24,
242
],
[
242,
6... | [
[
[
"Kanamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iopromide"
]
],
[
[
"Kanamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Torasemide"
],
[
"Torasemide",
"{u} may ... | Kanamycin may lead to a major life threatening interaction when taken with Torasemide and Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Kanamycin may cause a minor interaction that can limit clinical effects when taken with Nadolol and Nadolol may cause a moderate ... |
DB06691 | DB06702 | 849 | 573 | [
"DDInter1155",
"DDInter731"
] | Mepyramine | Fesoterodine | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
849,
24,
573
]
],
[
[
849,
63,
211
],
[
211,
1,
573
]
],
[
[
849,
6,
12523
],
[
12523,
45,
573
]
],
[
[
849,
74,
100
],
[
100,
2... | [
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Mepyramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
[... | Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Mepyramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fesoterodine (Compound)
Mepyramine (Compound) resembles Brompheniramine (Compound) a... |
DB01037 | DB08912 | 1,161 | 1,040 | [
"DDInter1653",
"DDInter462"
] | Selegiline | Dabrafenib | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1161,
24,
1040
]
],
[
[
1161,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1161,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
1161,
63,
245
],
[
24... | [
[
[
"Selegiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Selegiline",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Selegiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Selegiline (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Selegiline may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride... |
DB00708 | DB04843 | 1,454 | 1,511 | [
"DDInter1718",
"DDInter1149"
] | Sufentanil | Mepenzolate | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1454,
24,
1511
]
],
[
[
1454,
24,
537
],
[
537,
24,
1511
]
],
[
[
1454,
63,
352
],
[
352,
24,
1511
]
],
[
[
1454,
24,
649
],
[
649,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium ... |
DB00283 | DB00476 | 701 | 109 | [
"DDInter395",
"DDInter608"
] | Clemastine | Duloxetine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
701,
24,
109
]
],
[
[
701,
24,
758
],
[
758,
1,
109
]
],
[
[
701,
6,
12523
],
[
12523,
45,
109
]
],
[
[
701,
7,
1986
],
[
1986,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxetine"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Clemastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Duloxetine (Compound)
Clemastine (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) ... |
DB00559 | DB08907 | 152 | 1,344 | [
"DDInter223",
"DDInter280"
] | Bosentan | Canagliflozin | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
152,
24,
1344
]
],
[
[
152,
24,
549
],
[
549,
1,
1344
]
],
[
[
152,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
152,
21,
28681
],
[
28681,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Bosentan (Compound) causes Hypersensitivity (Side Effect) ... |
DB08901 | DB09104 | 1,468 | 286 | [
"DDInter1492",
"DDInter1118"
] | Ponatinib | Magnesium hydroxide | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
1468,
23,
286
]
],
[
[
1468,
63,
109
],
[
109,
23,
286
]
],
[
[
1468,
62,
752
],
[
752,
23,
286
]
],
[
[
1468,
64,
831
],
[
831,
... | [
[
[
"Ponatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
],
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Ponatinib may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cim... |
DB01234 | DB06655 | 1,220 | 5 | [
"DDInter513",
"DDInter1077"
] | Dexamethasone | Liraglutide | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1220,
24,
5
]
],
[
[
1220,
40,
1103
],
[
1103,
23,
5
]
],
[
[
1220,
63,
743
],
[
743,
23,
5
]
],
[
[
1220,
63,
915
],
[
915,
24,... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Dexamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Amcinonide"
],
[
"Amcinonide",
"{u} may cause a ... | Dexamethasone (Compound) resembles Amcinonide (Compound) and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril may cause a minor interaction that can... |
DB01222 | DB14723 | 617 | 159 | [
"DDInter246",
"DDInter1026"
] | Budesonide | Larotrectinib | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
617,
24,
159
]
],
[
[
617,
24,
1375
],
[
1375,
24,
159
]
],
[
[
617,
24,
1412
],
[
1412,
63,
159
]
],
[
[
617,
63,
597
],
[
597,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
[
... | Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol a... |
DB00719 | DB01173 | 1,219 | 358 | [
"DDInter149",
"DDInter1349"
] | Azatadine | Orphenadrine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
1219,
24,
358
]
],
[
[
1219,
24,
211
],
[
211,
1,
358
]
],
[
[
1219,
24,
272
],
[
272,
24,
358
]
],
[
[
1219,
63,
758
],
[
758,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Orphenadrine (Compound)
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interact... |
DB00196 | DB09080 | 600 | 144 | [
"DDInter743",
"DDInter1331"
] | Fluconazole | Olodaterol | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
600,
24,
144
]
],
[
[
600,
23,
1247
],
[
1247,
23,
144
]
],
[
[
600,
24,
956
],
[
956,
24,
144
]
],
[
[
600,
23,
504
],
[
504,
2... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Norfloxacin... |
DB09020 | DB09481 | 28 | 460 | [
"DDInter212",
"DDInter1113"
] | Bisacodyl | Magnesium carbonate | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
28,
24,
460
]
],
[
[
28,
63,
355
],
[
355,
23,
460
]
],
[
[
28,
63,
594
],
[
594,
24,
460
]
],
[
[
28,
24,
286
],
[
286,
24,
... | [
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
],
... | Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosu... |
DB01124 | DB04398 | 1,411 | 193 | [
"DDInter1828",
"DDInter1015"
] | Tolbutamide | Lactic acid | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed) Sodium lactate is the sodium salt of lactic acid, and has a mild saline taste. It is produced by fermentation of a sugar source, such as ... | Minor | 0 | [
[
[
1411,
23,
193
]
],
[
[
1411,
1,
959
],
[
959,
23,
193
]
],
[
[
1411,
24,
22
],
[
22,
24,
193
]
],
[
[
1411,
63,
1479
],
[
1479,
... | [
[
[
"Tolbutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lactic acid"
]
],
[
[
"Tolbutamide",
"{u} (Compound) resembles {v} (Compound)",
"Glipizide"
],
[
"Glipizide",
"{u} may cause a minor in... | Tolbutamide (Compound) resembles Glipizide (Compound) and Glipizide may cause a minor interaction that can limit clinical effects when taken with Lactic acid
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a moderate interaction that could ex... |
DB00193 | DB06704 | 534 | 247 | [
"DDInter1841",
"DDInter952"
] | Tramadol | Iobenguane (I-131) | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
534,
25,
247
]
],
[
[
534,
6,
7390
],
[
7390,
45,
247
]
],
[
[
534,
21,
28787
],
[
28787,
60,
247
]
],
[
[
534,
25,
820
],
[
820,
... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Tramadol",
"{u} (Compound) binds {v} (Gene)",
"SLC6A2"
],
[
"SLC6A2",
"{u} (Gene) is bound by {v} (Compound)",
"Iobenguane"... | Tramadol may lead to a major life threatening interaction when taken with Iobenguane
Tramadol (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Tramadol (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
Tramadol may lead to a majo... |
DB06674 | DB08889 | 908 | 350 | [
"DDInter837",
"DDInter299"
] | Golimumab | Carfilzomib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Major | 2 | [
[
[
908,
25,
350
]
],
[
[
908,
24,
1270
],
[
1270,
63,
350
]
],
[
[
908,
25,
1060
],
[
1060,
63,
350
]
],
[
[
908,
64,
482
],
[
482,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
]
],
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
... | Golimumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Golimumab may lead to a major life threatening interacti... |
DB00477 | DB01233 | 216 | 1,311 | [
"DDInter363",
"DDInter1197"
] | Chlorpromazine | Metoclopramide | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
216,
25,
1311
]
],
[
[
216,
24,
1151
],
[
1151,
40,
1311
]
],
[
[
216,
25,
1425
],
[
1425,
40,
1311
]
],
[
[
216,
6,
5289
],
[
5289,
... | [
[
[
"Chlorpromazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Chlorpromazine may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
Chl... |
DB00603 | DB00982 | 303 | 1,517 | [
"DDInter1137",
"DDInter991"
] | Medroxyprogesterone acetate | Isotretinoin | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Moderate | 1 | [
[
[
303,
24,
1517
]
],
[
[
303,
64,
640
],
[
640,
25,
1517
]
],
[
[
303,
7,
2475
],
[
2475,
46,
1517
]
],
[
[
303,
18,
8781
],
[
8781,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isotretinoin"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acitre... | Medroxyprogesterone acetate may lead to a major life threatening interaction when taken with Acitretin and Acitretin may lead to a major life threatening interaction when taken with Isotretinoin
Medroxyprogesterone acetate (Compound) upregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Isotretinoin (Compound)
Medr... |
DB01169 | DB06288 | 57 | 607 | [
"DDInter120",
"DDInter77"
] | Arsenic trioxide | Amisulpride | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Major | 2 | [
[
[
57,
25,
607
]
],
[
[
57,
62,
112
],
[
112,
23,
607
]
],
[
[
57,
64,
1352
],
[
1352,
24,
607
]
],
[
[
57,
63,
1559
],
[
1559,
24,... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amisulpride"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Amisulpride
Arsenic trioxide may lead to a major life threatening interaction when taken with Digoxin Immune Fab (O... |
DB00501 | DB09034 | 752 | 1,313 | [
"DDInter380",
"DDInter1733"
] | Cimetidine | Suvorexant | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Suvorexant is a selective dual antagonist of orexin receptors OX1R and OX2R that promotes sleep by reducing wakefulness and arousal. It has been approved for the treatment of insomnia. | Moderate | 1 | [
[
[
752,
24,
1313
]
],
[
[
752,
23,
1135
],
[
1135,
62,
1313
]
],
[
[
752,
25,
1213
],
[
1213,
24,
1313
]
],
[
[
752,
24,
1362
],
[
1362,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Suvorexant"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Suvorexant
Cimetidine may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a modera... |
DB00030 | DB00489 | 1,685 | 17 | [
"DDInter934",
"DDInter1704"
] | Insulin human | Sotalol | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
1685,
24,
17
]
],
[
[
1685,
24,
88
],
[
88,
40,
17
]
],
[
[
1685,
24,
417
],
[
417,
23,
17
]
],
[
[
1685,
24,
1479
],
[
1479,
62... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],
[... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can l... |
DB00196 | DB06788 | 600 | 1,616 | [
"DDInter743",
"DDInter864"
] | Fluconazole | Histrelin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
600,
24,
1616
]
],
[
[
600,
23,
112
],
[
112,
23,
1616
]
],
[
[
600,
24,
1664
],
[
1664,
24,
1616
]
],
[
[
600,
24,
603
],
[
603,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Ri... |
DB00877 | DB08904 | 629 | 375 | [
"DDInter1678",
"DDInter342"
] | Sirolimus | Certolizumab pegol | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Major | 2 | [
[
[
629,
25,
375
]
],
[
[
629,
62,
1461
],
[
1461,
23,
375
]
],
[
[
629,
23,
1193
],
[
1193,
62,
375
]
],
[
[
629,
63,
704
],
[
704,
... | [
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Sirolimus",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin... | Sirolimus may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Sirolimus may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc... |
DB00366 | DB01175 | 1,594 | 318 | [
"DDInter600",
"DDInter672"
] | Doxylamine | Escitalopram | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
1594,
24,
318
]
],
[
[
1594,
63,
1230
],
[
1230,
1,
318
]
],
[
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1594,
6,
10104
],
[
10104,
45,
318
]
],
[
[
1594,
21,
29579
],
[
2957... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Doxylamine (Compound) binds HRH1 (Gene) and HRH1 (Gene) is bound by Escitalopram (Compound)
Doxylamine (Compound) causes Breast disorder (Side Effect) and Bre... |
DB00270 | DB05679 | 1,428 | 1,683 | [
"DDInter993",
"DDInter1907"
] | Isradipine | Ustekinumab | Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affini... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
1428,
24,
1683
]
],
[
[
1428,
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],
[
1042,
24,
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[
[
1428,
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],
[
1093,
63,
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]
],
[
[
1428,
1,
409
],
[
409,... | [
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Isradipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
],
... | Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab
Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab a... |
DB00207 | DB09330 | 1,570 | 985 | [
"DDInter157",
"DDInter1352"
] | Azithromycin | Osimertinib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1570,
25,
985
]
],
[
[
1570,
23,
112
],
[
112,
23,
985
]
],
[
[
1570,
24,
480
],
[
480,
24,
985
]
],
[
[
1570,
24,
119
],
[
119,
... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Azithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and... |
DB00059 | DB00352 | 1,560 | 482 | [
"DDInter1404",
"DDInter1814"
] | Pegaspargase | Tioguanine | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Moderate | 1 | [
[
[
1560,
24,
482
]
],
[
[
1560,
24,
1299
],
[
1299,
62,
482
]
],
[
[
1560,
24,
151
],
[
151,
63,
482
]
],
[
[
1560,
24,
1324
],
[
1324,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trovafloxacin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Trovafloxacin and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Tioguanine
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Influenza A v... |
DB00254 | DB00524 | 964 | 811 | [
"DDInter598",
"DDInter1199"
] | Doxycycline | Metolazone | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Minor | 0 | [
[
[
964,
23,
811
]
],
[
[
964,
23,
1605
],
[
1605,
40,
811
]
],
[
[
964,
23,
1014
],
[
1014,
1,
811
]
],
[
[
964,
40,
1620
],
[
1620,
... | [
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metolazone"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Indapamide"
],
[
... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Indapamide and Indapamide (Compound) resembles Metolazone (Compound)
Doxycycline may cause a minor interaction that can limit clinical effects when taken with Benzthiazide and Benzthiazide (Compound) resembles Metolazone (Compound... |
DB00305 | DB12010 | 377 | 214 | [
"DDInter1232",
"DDInter785"
] | Mitomycin | Fostamatinib | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
377,
24,
214
]
],
[
[
377,
25,
976
],
[
976,
24,
214
]
],
[
[
377,
24,
51
],
[
51,
24,
214
]
],
[
[
377,
25,
676
],
[
676,
63,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Mitomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitin... | Mitomycin may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may ... |
DB11817 | DB12240 | 1,259 | 110 | [
"DDInter165",
"DDInter1485"
] | Baricitinib | Polatuzumab vedotin | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Major | 2 | [
[
[
1259,
25,
110
]
],
[
[
1259,
64,
1419
],
[
1419,
24,
110
]
],
[
[
1259,
63,
810
],
[
810,
24,
110
]
],
[
[
1259,
25,
270
],
[
270,
... | [
[
[
"Baricitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Baricitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Imatinib"
],
[
"Imatinib",
... | Baricitinib may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin
Baricitinib may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and ... |
DB11791 | DB11979 | 785 | 1,320 | [
"DDInter287",
"DDInter625"
] | Capmatinib | Elagolix | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
785,
24,
1320
]
],
[
[
785,
63,
608
],
[
608,
23,
1320
]
],
[
[
785,
64,
129
],
[
129,
24,
1320
]
],
[
[
785,
63,
372
],
[
372,
... | [
[
[
"Capmatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Capmatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Capmatinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Elagolix
Capmatinib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a ... |
DB00486 | DB04837 | 1,614 | 649 | [
"DDInter1253",
"DDInter407"
] | Nabilone | Clofedanol | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1614,
24,
649
]
],
[
[
1614,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1614,
63,
21
],
[
21,
24,
649
]
],
[
[
1614,
25,
675
],
[
675,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline a... |
DB05679 | DB06228 | 1,683 | 792 | [
"DDInter1907",
"DDInter1609"
] | Ustekinumab | Rivaroxaban | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1683,
24,
792
]
],
[
[
1683,
63,
453
],
[
453,
40,
792
]
],
[
[
1683,
24,
1303
],
[
1303,
63,
792
]
],
[
[
1683,
63,
597
],
[
597,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
],
[
... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Linezolid and Linezolid (Compound) resembles Rivaroxaban (Compound)
Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab and Guselkumab may cause a moderate interaction that coul... |
DB00372 | DB01181 | 999 | 1,532 | [
"DDInter1793",
"DDInter906"
] | Thiethylperazine | Ifosfamide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
999,
24,
1532
]
],
[
[
999,
63,
1648
],
[
1648,
24,
1532
]
],
[
[
999,
25,
684
],
[
684,
24,
1532
]
],
[
[
999,
24,
1170
],
[
1170,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Thiethylperazine may lead to a major life threatening interaction when taken with Thioridazine and Thior... |
DB00582 | DB06605 | 1,622 | 1,409 | [
"DDInter1946",
"DDInter108"
] | Voriconazole | Apixaban | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1622,
25,
1409
]
],
[
[
1622,
6,
10215
],
[
10215,
45,
1409
]
],
[
[
1622,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
1622,
25,
1670
],
[
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
"Api... | Voriconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Apixaban (Compound)
Voriconazole (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may caus... |
DB00286 | DB00731 | 380 | 1,144 | [
"DDInter439",
"DDInter1269"
] | Conjugated estrogens | Nateglinide | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
380,
24,
1144
]
],
[
[
380,
6,
9320
],
[
9320,
45,
1144
]
],
[
[
380,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
380,
24,
1051
],
[
1051,... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"ABCC4"
],
[
"ABCC4",
"{u} (Gene) is bound ... | Conjugated estrogens (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Nateglinide (Compound)
Conjugated estrogens (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases whe... |
DB00252 | DB09112 | 362 | 1,455 | [
"DDInter1460",
"DDInter1306"
] | Phenytoin | Nitrous acid | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Major | 2 | [
[
[
362,
25,
1455
]
],
[
[
362,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
362,
24,
433
],
[
433,
63,
1455
]
],
[
[
362,
1,
697
],
[
697,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nitrous acid"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[
"Empagli... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin a... |
DB00405 | DB01219 | 128 | 716 | [
"DDInter517",
"DDInter473"
] | Dexbrompheniramine | Dantrolene | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. | Moderate | 1 | [
[
[
128,
24,
716
]
],
[
[
128,
24,
1609
],
[
1609,
63,
716
]
],
[
[
128,
24,
100
],
[
100,
24,
716
]
],
[
[
128,
63,
1242
],
[
1242,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dantrolene"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyveri... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Dantrolene
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01259 | DB11730 | 392 | 351 | [
"DDInter1024",
"DDInter1588"
] | Lapatinib | Ribociclib | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
392,
25,
351
]
],
[
[
392,
23,
271
],
[
271,
23,
351
]
],
[
[
392,
24,
466
],
[
466,
62,
351
]
],
[
[
392,
62,
1247
],
[
1247,
2... | [
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Lapatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
],
[
"Mirabegron",
... | Lapatinib may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutami... |
DB00347 | DB00358 | 917 | 1,010 | [
"DDInter1871",
"DDInter1140"
] | Trimethadione | Mefloquine | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
917,
24,
1010
]
],
[
[
917,
6,
8374
],
[
8374,
45,
1010
]
],
[
[
917,
21,
28810
],
[
28810,
60,
1010
]
],
[
[
917,
24,
1311
],
[
1311,... | [
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Trimethadione",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Trimethadione (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound)
Trimethadione (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Mefloquine (Compound)
Trimethadione may cause a moderate interaction that could exacerbate diseases wh... |
DB00321 | DB09278 | 21 | 852 | [
"DDInter78",
"DDInter24"
] | Amitriptyline | Activated charcoal | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
21,
24,
852
]
],
[
[
21,
24,
1411
],
[
1411,
24,
852
]
],
[
[
21,
40,
1164
],
[
1164,
24,
852
]
],
[
[
21,
35,
1264
],
[
1264,
2... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Amitriptyline (Compound) resembles Trimipramine (Compound) and Trimipramine may cause a moderate in... |
DB11730 | DB12941 | 351 | 466 | [
"DDInter1588",
"DDInter481"
] | Ribociclib | Darolutamide | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Minor | 0 | [
[
[
351,
23,
466
]
],
[
[
351,
64,
1622
],
[
1622,
23,
466
]
],
[
[
351,
63,
1623
],
[
1623,
23,
466
]
],
[
[
351,
23,
283
],
[
283,
... | [
[
[
"Ribociclib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
]
],
[
[
"Ribociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Voricona... | Ribociclib may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium and Isavuconazon... |
DB00358 | DB01177 | 1,010 | 77 | [
"DDInter1140",
"DDInter904"
] | Mefloquine | Idarubicin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
1010,
24,
77
]
],
[
[
1010,
6,
12523
],
[
12523,
45,
77
]
],
[
[
1010,
18,
2183
],
[
2183,
57,
77
]
],
[
[
1010,
7,
5998
],
[
5998,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Mefloquine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Mefloquine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Idarubicin (Compound)
Mefloquine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is downregulated by Idarubicin (Compound)
Mefloquine (... |
DB00754 | DB09054 | 157 | 384 | [
"DDInter696",
"DDInter905"
] | Ethotoin | Idelalisib | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
157,
24,
384
]
],
[
[
157,
24,
222
],
[
222,
23,
384
]
],
[
[
157,
63,
305
],
[
305,
24,
384
]
],
[
[
157,
24,
891
],
[
891,
24,... | [
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia ... |
DB00990 | DB12130 | 1,547 | 1,017 | [
"DDInter705",
"DDInter1094"
] | Exemestane | Lorlatinib | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1547,
24,
1017
]
],
[
[
1547,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
1547,
63,
629
],
[
629,
24,
1017
]
],
[
[
1547,
24,
214
],
[
214,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus... |
DB00427 | DB00454 | 1,233 | 1,349 | [
"DDInter1879",
"DDInter1150"
] | Triprolidine | Meperidine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Moderate | 1 | [
[
[
1233,
24,
1349
]
],
[
[
1233,
24,
411
],
[
411,
1,
1349
]
],
[
[
1233,
6,
12523
],
[
12523,
45,
1349
]
],
[
[
1233,
24,
100
],
[
100,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meperidine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remifentanil"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Remifentanil and Remifentanil (Compound) resembles Meperidine (Compound)
Triprolidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Meperidine (Compound)
Triprolidine may cause a moderate interaction that could e... |
DB00029 | DB12364 | 25 | 1,421 | [
"DDInter99",
"DDInter200"
] | Anistreplase | Betrixaban | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
25,
25,
1421
]
],
[
[
25,
23,
297
],
[
297,
23,
1421
]
],
[
[
25,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
25,
24,
992
],
[
992,
24... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Anistreplase may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a... |
DB00515 | DB01267 | 589 | 519 | [
"DDInter387",
"DDInter1381"
] | Cisplatin | Paliperidone | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
589,
24,
519
]
],
[
[
589,
24,
1664
],
[
1664,
1,
519
]
],
[
[
589,
21,
28695
],
[
28695,
60,
519
]
],
[
[
589,
24,
112
],
[
112,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Cisplatin (Compound) causes Dyspnoea (Side Effect) and Dyspnoea (Side Effect) is caused by Paliperidone (Compound)
Cisplatin may cause a moderate interaction... |
DB00451 | DB09104 | 542 | 286 | [
"DDInter1064",
"DDInter1118"
] | Levothyroxine | Magnesium hydroxide | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
542,
24,
286
]
],
[
[
542,
24,
1482
],
[
1482,
23,
286
]
],
[
[
542,
62,
88
],
[
88,
23,
286
]
],
[
[
542,
23,
752
],
[
752,
23,... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol a... |
DB00153 | DB09146 | 1,331 | 489 | [
"DDInter662",
"DDInter978"
] | Ergocalciferol | Iron sucrose | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, ir... | Moderate | 1 | [
[
[
1331,
24,
489
]
],
[
[
1331,
36,
386
],
[
386,
24,
489
]
],
[
[
1331,
64,
160
],
[
160,
24,
489
]
],
[
[
1331,
25,
1196
],
[
1196,
... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron sucrose"
]
],
[
[
"Ergocalciferol",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {... | Ergocalciferol (Compound) resembles Cholecalciferol (Compound) and Ergocalciferol may lead to a major life threatening interaction when taken with Cholecalciferol and Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Iron sucrose
Ergocalciferol may lead to a major life thre... |
DB04845 | DB06372 | 309 | 259 | [
"DDInter1001",
"DDInter1594"
] | Ixabepilone | Rilonacept | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
309,
24,
259
]
],
[
[
309,
63,
1461
],
[
1461,
23,
259
]
],
[
[
309,
24,
1619
],
[
1619,
63,
259
]
],
[
[
309,
24,
478
],
[
478,
... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib... |
DB00010 | DB01278 | 1,649 | 1,021 | [
"DDInter1661",
"DDInter1506"
] | Sermorelin | Pramlintide | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Moderate | 1 | [
[
[
1649,
24,
1021
]
],
[
[
1649,
24,
1144
],
[
1144,
24,
1021
]
],
[
[
1649,
24,
1296
],
[
1296,
63,
1021
]
],
[
[
1649,
24,
1144
],
[
11... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pramlintide"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Pramlintide
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec a... |
DB00446 | DB06616 | 597 | 594 | [
"DDInter351",
"DDInter224"
] | Chloramphenicol | Bosutinib | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
597,
24,
594
]
],
[
[
597,
63,
883
],
[
883,
1,
594
]
],
[
[
597,
7,
1972
],
[
1972,
45,
594
]
],
[
[
597,
6,
8374
],
[
8374,
45... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Chloramphenicol (Compound) upregulates PRKCQ (Gene) and PRKCQ (Gene) is bound by Bosutinib (Compound)
Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A... |
DB00603 | DB01124 | 303 | 1,411 | [
"DDInter1137",
"DDInter1828"
] | Medroxyprogesterone acetate | Tolbutamide | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
303,
24,
1411
]
],
[
[
303,
24,
959
],
[
959,
40,
1411
]
],
[
[
303,
63,
245
],
[
245,
40,
1411
]
],
[
[
303,
6,
3486
],
[
3486,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compoun... |
DB00557 | DB09272 | 252 | 412 | [
"DDInter895",
"DDInter632"
] | Hydroxyzine | Eluxadoline | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
252,
24,
412
]
],
[
[
252,
63,
1594
],
[
1594,
24,
412
]
],
[
[
252,
24,
543
],
[
543,
24,
412
]
],
[
[
252,
64,
475
],
[
475,
2... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lop... |
DB09054 | DB11828 | 384 | 1,406 | [
"DDInter905",
"DDInter1281"
] | Idelalisib | Neratinib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
384,
25,
1406
]
],
[
[
384,
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],
[
1135,
23,
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[
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[
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384,
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],
[
1195,
... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Idelalisib may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Idelalisib may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interaction... |
DB00877 | DB11921 | 629 | 1,019 | [
"DDInter1678",
"DDInter492"
] | Sirolimus | Deflazacort | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
629,
24,
1019
]
],
[
[
629,
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],
[
1193,
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],
[
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],
[
1461,
23,
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]
],
[
[
629,
24,
959
],
[
959,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Sirolimus",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Sirolimus may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Sirolimus may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitami... |
DB00860 | DB06335 | 891 | 761 | [
"DDInter1513",
"DDInter1646"
] | Prednisolone | Saxagliptin | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
891,
24,
761
]
],
[
[
891,
6,
8374
],
[
8374,
45,
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[
[
891,
21,
28722
],
[
28722,
60,
761
]
],
[
[
891,
62,
307
],
[
307,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Prednisolone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Prednisolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Saxagliptin (Compound)
Prednisolone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Saxagliptin (Compound)
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modaf... |
DB00030 | DB00795 | 1,685 | 50 | [
"DDInter934",
"DDInter1725"
] | Insulin human | Sulfasalazine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
1685,
24,
50
]
],
[
[
1685,
24,
161
],
[
161,
1,
50
]
],
[
[
1685,
63,
305
],
[
305,
24,
50
]
],
[
[
1685,
24,
959
],
[
959,
63,... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfadiazine"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasalazine (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherich... |
DB00295 | DB00376 | 475 | 1,105 | [
"DDInter1244",
"DDInter1870"
] | Morphine | Trihexyphenidyl | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Moderate | 1 | [
[
[
475,
24,
1105
]
],
[
[
475,
24,
456
],
[
456,
1,
1105
]
],
[
[
475,
24,
1386
],
[
1386,
40,
1105
]
],
[
[
475,
21,
28676
],
[
28676,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Biperiden"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Biperiden and Biperiden (Compound) resembles Trihexyphenidyl (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Procyclidine and Procyclidine (Compound) resembles Trihexyphenidyl (Co... |
DB12130 | DB12941 | 1,017 | 466 | [
"DDInter1094",
"DDInter481"
] | Lorlatinib | Darolutamide | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Major | 2 | [
[
[
1017,
25,
466
]
],
[
[
1017,
64,
1622
],
[
1622,
23,
466
]
],
[
[
1017,
63,
34
],
[
34,
23,
466
]
],
[
[
1017,
25,
283
],
[
283,
... | [
[
[
"Lorlatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
]
],
[
[
"Lorlatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Voriconazole",
... | Lorlatinib may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir ... |
DB09043 | DB09128 | 135 | 1,241 | [
"DDInter36",
"DDInter231"
] | Albiglutide | Brexpiprazole | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
135,
24,
1241
]
],
[
[
135,
62,
1647
],
[
1647,
24,
1241
]
],
[
[
135,
24,
1296
],
[
1296,
63,
1241
]
],
[
[
135,
63,
1179
],
[
1179,
... | [
[
[
"Albiglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Albiglutide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acarbose"
],
[
... | Albiglutide may cause a minor interaction that can limit clinical effects when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Albiglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and I... |
DB01159 | DB06209 | 419 | 256 | [
"DDInter854",
"DDInter1508"
] | Halothane | Prasugrel | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Minor | 0 | [
[
[
419,
23,
256
]
],
[
[
419,
6,
8374
],
[
8374,
45,
256
]
],
[
[
419,
63,
888
],
[
888,
23,
256
]
],
[
[
419,
63,
475
],
[
475,
24... | [
[
[
"Halothane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prasugrel"
]
],
[
[
"Halothane",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Halothane (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prasugrel (Compound)
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Prasugrel
Halothane may cause a mode... |
DB00344 | DB08897 | 1,302 | 1,429 | [
"DDInter1543",
"DDInter22"
] | Protriptyline | Aclidinium | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
1302,
24,
1429
]
],
[
[
1302,
63,
352
],
[
352,
24,
1429
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],
[
[
1302,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
1302,
21,
28817
],
[
288... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mep... |
DB00987 | DB14783 | 1,224 | 287 | [
"DDInter460",
"DDInter574"
] | Cytarabine | Diroximel fumarate | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1224,
24,
287
]
],
[
[
1224,
64,
1101
],
[
1101,
24,
287
]
],
[
[
1224,
63,
1560
],
[
1560,
24,
287
]
],
[
[
1224,
24,
384
],
[
384,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Cytarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Be... | Cytarabine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargas... |
DB01218 | DB12161 | 1,493 | 730 | [
"DDInter852",
"DDInter512"
] | Halofantrine | Deutetrabenazine | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Major | 2 | [
[
[
1493,
25,
730
]
],
[
[
1493,
62,
112
],
[
112,
23,
730
]
],
[
[
1493,
64,
322
],
[
322,
24,
730
]
],
[
[
1493,
63,
1559
],
[
1559,
... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Halofantrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Halofantrine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Halofantrine may lead to a major life threatening interaction when taken with Epirubicin and Epirubici... |
DB00911 | DB08870 | 458 | 850 | [
"DDInter1811",
"DDInter228"
] | Tinidazole | Brentuximab vedotin | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
458,
24,
850
]
],
[
[
458,
24,
788
],
[
788,
24,
850
]
],
[
[
458,
63,
896
],
[
896,
24,
850
]
],
[
[
458,
24,
1155
],
[
1155,
6... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Etoposid... |
DB00468 | DB11110 | 1,424 | 603 | [
"DDInter1557",
"DDInter1115"
] | Quinine | Magnesium citrate | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1424,
24,
603
]
],
[
[
1424,
25,
57
],
[
57,
24,
603
]
],
[
[
1424,
24,
789
],
[
789,
24,
603
]
],
[
[
1424,
64,
494
],
[
494,
2... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
"Ars... | Quinine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Foscarnet... |
DB00619 | DB00834 | 1,419 | 932 | [
"DDInter909",
"DDInter1215"
] | Imatinib | Mifepristone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Moderate | 1 | [
[
[
1419,
24,
932
]
],
[
[
1419,
6,
7524
],
[
7524,
45,
932
]
],
[
[
1419,
21,
28762
],
[
28762,
60,
932
]
],
[
[
1419,
62,
1101
],
[
1101... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mifepristone"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Mifepristone (Compound)
Imatinib (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Mifepristone (Compound)
Imatinib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene... |
DB00065 | DB00694 | 581 | 51 | [
"DDInter923",
"DDInter485"
] | Infliximab | Daunorubicin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Major | 2 | [
[
[
581,
25,
51
]
],
[
[
581,
24,
112
],
[
112,
62,
51
]
],
[
[
581,
24,
1430
],
[
1430,
63,
51
]
],
[
[
581,
25,
1468
],
[
1468,
63... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Daunorubicin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metro... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Daunorubicin
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T an... |
DB00480 | DB12035 | 1,668 | 943 | [
"DDInter1035",
"DDInter1641"
] | Lenalidomide | Sarecycline | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1668,
24,
943
]
],
[
[
1668,
24,
1670
],
[
1670,
24,
943
]
],
[
[
1668,
23,
126
],
[
126,
24,
943
]
],
[
[
1668,
63,
322
],
[
322,
... | [
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Lenalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
],
... | Lenalidomide may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Lenalidomide may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfa... |
DB01396 | DB11093 | 1,482 | 636 | [
"DDInter553",
"DDInter273"
] | Digitoxin | Calcium citrate | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1482,
24,
636
]
],
[
[
1482,
63,
1572
],
[
1572,
24,
636
]
],
[
[
1482,
40,
1252
],
[
1252,
24,
636
]
],
[
[
1482,
23,
115
],
[
115,
... | [
[
[
"Digitoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Digitoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],
... | Digitoxin may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Digitoxin (Compound) resembles Digoxin (Compound) and Digoxin may cause a moderate interaction that ... |
DB00604 | DB13074 | 1,425 | 877 | [
"DDInter385",
"DDInter1110"
] | Cisapride | Macimorelin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1425,
25,
877
]
],
[
[
1425,
23,
112
],
[
112,
23,
877
]
],
[
[
1425,
63,
85
],
[
85,
24,
877
]
],
[
[
1425,
24,
673
],
[
673,
2... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropin... |
DB00501 | DB01242 | 752 | 1,237 | [
"DDInter380",
"DDInter410"
] | Cimetidine | Clomipramine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
752,
24,
1237
]
],
[
[
752,
25,
684
],
[
684,
1,
1237
]
],
[
[
752,
24,
1164
],
[
1164,
1,
1237
]
],
[
[
752,
63,
902
],
[
902,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Cimetidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
],
[
"Thiori... | Cimetidine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
Cim... |
DB00384 | DB09038 | 1,275 | 1,450 | [
"DDInter1859",
"DDInter636"
] | Triamterene | Empagliflozin | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1275,
24,
1450
]
],
[
[
1275,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
1275,
24,
1486
],
[
1486,
24,
1450
]
],
[
[
1275,
24,
1455
],
[
14... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Methylpredni... |
DB00747 | DB01242 | 1,442 | 1,237 | [
"DDInter1647",
"DDInter410"
] | Scopolamine | Clomipramine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
1442,
24,
1237
]
],
[
[
1442,
63,
684
],
[
684,
1,
1237
]
],
[
[
1442,
24,
272
],
[
272,
24,
1237
]
],
[
[
1442,
24,
146
],
[
146,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate in... |
DB00367 | DB01024 | 566 | 1,096 | [
"DDInter1061",
"DDInter1252"
] | Levonorgestrel | Mycophenolic acid | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Major | 2 | [
[
[
566,
25,
1096
]
],
[
[
566,
18,
5930
],
[
5930,
45,
1096
]
],
[
[
566,
7,
18134
],
[
18134,
46,
1096
]
],
[
[
566,
18,
2389
],
[
2389,... | [
[
[
"Levonorgestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) downregulates {v} (Gene)",
"IMPDH2"
],
[
"IMPDH2",
"{u} (Gene) is bound by {v} (Com... | Levonorgestrel (Compound) downregulates IMPDH2 (Gene) and IMPDH2 (Gene) is bound by Mycophenolic acid (Compound)
Levonorgestrel (Compound) upregulates POLD4 (Gene) and POLD4 (Gene) is upregulated by Mycophenolic acid (Compound)
Levonorgestrel (Compound) downregulates CCDC85B (Gene) and CCDC85B (Gene) is upregulated by ... |
DB00916 | DB05812 | 112 | 1,374 | [
"DDInter1202",
"DDInter8"
] | Metronidazole | Abiraterone | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Minor | 0 | [
[
[
112,
23,
1374
]
],
[
[
112,
6,
8374
],
[
8374,
45,
1374
]
],
[
[
112,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
112,
23,
1247
],
[
1247,... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Abiraterone"
]
],
[
[
"Metronidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Abiraterone (Compound)
Metronidazole (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Sulfametho... |
DB01166 | DB04865 | 477 | 4 | [
"DDInter379",
"DDInter1335"
] | Cilostazol | Omacetaxine mepesuccinate | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
477,
25,
4
]
],
[
[
477,
7,
4450
],
[
4450,
46,
4
]
],
[
[
477,
18,
16896
],
[
16896,
57,
4
]
],
[
[
477,
63,
770
],
[
770,
24,
... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Cilostazol",
"{u} (Compound) upregulates {v} (Gene)",
"RRP8"
],
[
"RRP8",
"{u} (Gene) is upregulated by {v} (Com... | Cilostazol (Compound) upregulates RRP8 (Gene) and RRP8 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Cilostazol (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Omacetaxine mepesuccinate (Compound)
Cilostazol may cause a moderate interaction that could exacerbate diseases when ... |
DB00682 | DB01044 | 126 | 246 | [
"DDInter1951",
"DDInter809"
] | Warfarin | Gatifloxacin | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
126,
25,
246
]
],
[
[
126,
25,
739
],
[
739,
1,
246
]
],
[
[
126,
64,
1176
],
[
1176,
1,
246
]
],
[
[
126,
25,
945
],
[
945,
40,... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
],
[
"Lomefloxacin",
"{u}... | Warfarin may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Warfarin may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Warfarin may lead to a... |
DB00443 | DB00705 | 251 | 441 | [
"DDInter195",
"DDInter496"
] | Betamethasone | Delavirdine | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
251,
24,
441
]
],
[
[
251,
6,
8374
],
[
8374,
45,
441
]
],
[
[
251,
21,
28709
],
[
28709,
60,
441
]
],
[
[
251,
1,
1220
],
[
1220,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Betamethasone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Delavirdine (Compound)
Betamethasone (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Betamethasone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may ca... |
DB00736 | DB09263 | 660 | 1,436 | [
"DDInter676",
"DDInter1399"
] | Esomeprazole | Patiromer | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
660,
24,
1436
]
],
[
[
660,
24,
428
],
[
428,
63,
1436
]
],
[
[
660,
40,
837
],
[
837,
24,
1436
]
],
[
[
660,
63,
1152
],
[
1152,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
],... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Esomeprazole (Compound) resembles Pantoprazole (Compound) and Pantoprazole may cause a moderate int... |
DB06674 | DB11834 | 908 | 1,303 | [
"DDInter837",
"DDInter849"
] | Golimumab | Guselkumab | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Major | 2 | [
[
[
908,
25,
1303
]
],
[
[
908,
23,
1193
],
[
1193,
23,
1303
]
],
[
[
908,
62,
1461
],
[
1461,
23,
1303
]
],
[
[
908,
63,
792
],
[
792,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Guselkumab"
]
],
[
[
"Golimumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc gluco... | Golimumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Guselkumab
Golimumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin... |
DB00242 | DB08870 | 1,064 | 850 | [
"DDInter392",
"DDInter228"
] | Cladribine | Brentuximab vedotin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Major | 2 | [
[
[
1064,
25,
850
]
],
[
[
1064,
24,
496
],
[
496,
63,
850
]
],
[
[
1064,
25,
611
],
[
611,
24,
850
]
],
[
[
1064,
25,
1583
],
[
1583,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Cladribine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
[... | Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Cladribine may lead to a major life threatening interaction when taken with Dacarbazi... |
DB00812 | DB01229 | 998 | 973 | [
"DDInter1451",
"DDInter1377"
] | Phenylbutazone | Paclitaxel | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
998,
24,
973
]
],
[
[
998,
24,
310
],
[
310,
63,
973
]
],
[
[
998,
6,
8374
],
[
8374,
45,
973
]
],
[
[
998,
40,
307
],
[
307,
23... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Phenylbu... |
DB09330 | DB11652 | 985 | 1,155 | [
"DDInter1352",
"DDInter1891"
] | Osimertinib | Tucatinib | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Major | 2 | [
[
[
985,
25,
1155
]
],
[
[
985,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
985,
64,
1424
],
[
1424,
24,
1155
]
],
[
[
985,
63,
659
],
[
659,
... | [
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tucatinib"
]
],
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexaroten... | Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Osimertinib may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a moder... |
DB00445 | DB05294 | 322 | 1,069 | [
"DDInter655",
"DDInter1917"
] | Epirubicin | Vandetanib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
322,
25,
1069
]
],
[
[
322,
24,
1195
],
[
1195,
40,
1069
]
],
[
[
322,
63,
883
],
[
883,
40,
1069
]
],
[
[
322,
5,
11648
],
[
11648,
... | [
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
"Erlotinib",... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Vandetanib (Compound)
Epir... |
DB00530 | DB01129 | 1,195 | 379 | [
"DDInter667",
"DDInter1559"
] | Erlotinib | Rabeprazole | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Major | 2 | [
[
[
1195,
25,
379
]
],
[
[
1195,
64,
1215
],
[
1215,
40,
379
]
],
[
[
1195,
25,
660
],
[
660,
1,
379
]
],
[
[
1195,
64,
837
],
[
837,
... | [
[
[
"Erlotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rabeprazole"
]
],
[
[
"Erlotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lansoprazole"
],
[
"Lansoprazole",
"{u... | Erlotinib may lead to a major life threatening interaction when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Erlotinib may lead to a major life threatening interaction when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole (Compound)
Erlotinib may lead to ... |
DB01206 | DB08886 | 37 | 637 | [
"DDInter1086",
"DDInter126"
] | Lomustine | Asparaginase Erwinia chrysanthemi | An alkylating agent of value against both hematologic malignancies and solid tumors. | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
37,
24,
637
]
],
[
[
37,
63,
328
],
[
328,
24,
637
]
],
[
[
37,
24,
850
],
[
850,
24,
637
]
],
[
[
37,
24,
1613
],
[
1613,
63,
... | [
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Lomustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercap... | Lomustine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Lomustine may cause a moderate interaction that could exacerbate diseases when tak... |
DB00586 | DB00594 | 1,512 | 863 | [
"DDInter537",
"DDInter68"
] | Diclofenac | Amiloride | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Moderate | 1 | [
[
[
1512,
24,
863
]
],
[
[
1512,
6,
5538
],
[
5538,
45,
863
]
],
[
[
1512,
21,
29434
],
[
29434,
60,
863
]
],
[
[
1512,
62,
752
],
[
752,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiloride"
]
],
[
[
"Diclofenac",
"{u} (Compound) binds {v} (Gene)",
"ASIC1"
],
[
"ASIC1",
"{u} (Gene) is bound by {v} (Compound)",
... | Diclofenac (Compound) binds ASIC1 (Gene) and ASIC1 (Gene) is bound by Amiloride (Compound)
Diclofenac (Compound) causes Angina pectoris (Side Effect) and Angina pectoris (Side Effect) is caused by Amiloride (Compound)
Diclofenac may cause a minor interaction that can limit clinical effects when taken with Cimetidine an... |
DB00307 | DB09389 | 1,101 | 517 | [
"DDInter202",
"DDInter1315"
] | Bexarotene | Norgestrel | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Major | 2 | [
[
[
1101,
25,
517
]
],
[
[
1101,
24,
1130
],
[
1130,
23,
517
]
],
[
[
1101,
25,
52
],
[
52,
24,
517
]
],
[
[
1101,
24,
159
],
[
159,
... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Norgestrel"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
[
"Pioglita... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a minor interaction that can limit clinical effects when taken with Norgestrel
Bexarotene may lead to a major life threatening interaction when taken with Dulaglutide and Dulaglutide may ca... |
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