drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB08865 | DB08880 | 1,593 | 1,510 | [
"DDInter448",
"DDInter1771"
] | Crizotinib | Teriflunomide | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1593,
25,
1510
]
],
[
[
1593,
25,
129
],
[
129,
63,
1510
]
],
[
[
1593,
24,
505
],
[
505,
63,
1510
]
],
[
[
1593,
63,
1191
],
[
1191,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Crizotinib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Diiodohydroxyquinoline and Di... |
DB00526 | DB00927 | 1,555 | 1,559 | [
"DDInter1355",
"DDInter712"
] | Oxaliplatin | Famotidine | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
1555,
24,
1559
]
],
[
[
1555,
6,
8803
],
[
8803,
45,
1559
]
],
[
[
1555,
63,
886
],
[
886,
23,
1559
]
],
[
[
1555,
24,
935
],
[
935,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Oxaliplatin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A2"
],
[
"SLC22A2",
"{u} (Gene) is bound by {v} (Compoun... | Oxaliplatin (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Famotidine (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac may cause a minor interaction that can limit clinical effects when taken with Famotidine
Oxaliplatin may ca... |
DB00601 | DB00682 | 453 | 126 | [
"DDInter1073",
"DDInter1951"
] | Linezolid | Warfarin | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
453,
24,
126
]
],
[
[
453,
24,
1376
],
[
1376,
40,
126
]
],
[
[
453,
63,
168
],
[
168,
23,
126
]
],
[
[
453,
25,
1053
],
[
1053,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that ca... |
DB00661 | DB09112 | 122 | 1,455 | [
"DDInter1928",
"DDInter1306"
] | Verapamil | Nitrous acid | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
122,
24,
1455
]
],
[
[
122,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
122,
24,
433
],
[
433,
63,
1455
]
],
[
[
122,
63,
1061
],
[
1061,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[... | Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin a... |
DB00361 | DB01394 | 134 | 1,554 | [
"DDInter1939",
"DDInter431"
] | Vinorelbine | Colchicine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Moderate | 1 | [
[
[
134,
24,
1554
]
],
[
[
134,
6,
4973
],
[
4973,
45,
1554
]
],
[
[
134,
6,
16974
],
[
16974,
46,
1554
]
],
[
[
134,
7,
6736
],
[
6736,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colchicine"
]
],
[
[
"Vinorelbine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Vinorelbine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Colchicine (Compound)
Vinorelbine (Compound) binds TUBB6 (Gene) and TUBB6 (Gene) is upregulated by Colchicine (Compound)
Vinorelbine (Compound) upregulates DRAP1 (Gene) and DRAP1 (Gene) is upregulated by Colchicine (Compound)
Vinorelbine (Compound) ... |
DB00678 | DB00712 | 240 | 1,274 | [
"DDInter1095",
"DDInter763"
] | Losartan | Flurbiprofen | Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension. Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough. When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough simila... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
240,
24,
1274
]
],
[
[
240,
6,
15705
],
[
15705,
45,
1274
]
],
[
[
240,
21,
28769
],
[
28769,
60,
1274
]
],
[
[
240,
63,
254
],
[
254,... | [
[
[
"Losartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Losartan",
"{u} (Compound) binds {v} (Gene)",
"UGT1A1"
],
[
"UGT1A1",
"{u} (Gene) is bound by {v} (Compound)",
... | Losartan (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Flurbiprofen (Compound)
Losartan (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Flurbiprofen (Compound)
Losartan may cause a moderate interaction that could exacerbate diseases when taken with Nitisin... |
DB00261 | DB00281 | 702 | 608 | [
"DDInter93",
"DDInter1066"
] | Anagrelide | Lidocaine | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication . In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anes... | Moderate | 1 | [
[
[
702,
24,
608
]
],
[
[
702,
6,
7950
],
[
7950,
45,
608
]
],
[
[
702,
21,
28722
],
[
28722,
60,
608
]
],
[
[
702,
25,
371
],
[
371,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
]
],
[
[
"Anagrelide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Lidocaine (Compound)
Anagrelide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lidocaine (Compound)
Anagrelide may lead to a major life threatening interaction when taken with Propafenone and Propafenone may cause a mi... |
DB01069 | DB06707 | 401 | 584 | [
"DDInter1533",
"DDInter1060"
] | Promethazine | Levonordefrin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Levonordefrin acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. | Moderate | 1 | [
[
[
401,
24,
584
]
],
[
[
401,
24,
1191
],
[
1191,
40,
584
]
],
[
[
401,
63,
817
],
[
817,
40,
584
]
],
[
[
401,
63,
1148
],
[
1148,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levonordefrin"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Levodopa and Levodopa (Compound) resembles Levonordefrin (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Dopamine and Dopamine (Compound) resembles Levonordefrin (Compound... |
DB00363 | DB06650 | 695 | 1,500 | [
"DDInter419",
"DDInter1324"
] | Clozapine | Ofatumumab | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Major | 2 | [
[
[
695,
25,
1500
]
],
[
[
695,
25,
869
],
[
869,
24,
1500
]
],
[
[
695,
25,
1362
],
[
1362,
63,
1500
]
],
[
[
695,
64,
599
],
[
599,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofatumumab"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Topotecan"
],
[
"Topotecan",
"{u} may c... | Clozapine may lead to a major life threatening interaction when taken with Topotecan and Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Ofatumumab
Clozapine may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction ... |
DB01030 | DB06616 | 869 | 594 | [
"DDInter1835",
"DDInter224"
] | Topotecan | Bosutinib | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
869,
24,
594
]
],
[
[
869,
18,
2030
],
[
2030,
45,
594
]
],
[
[
869,
7,
4181
],
[
4181,
45,
594
]
],
[
[
869,
6,
8374
],
[
8374,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Topotecan",
"{u} (Compound) downregulates {v} (Gene)",
"ABL1"
],
[
"ABL1",
"{u} (Gene) is bound by {v} (Compound)"... | Topotecan (Compound) downregulates ABL1 (Gene) and ABL1 (Gene) is bound by Bosutinib (Compound)
Topotecan (Compound) upregulates SYK (Gene) and SYK (Gene) is bound by Bosutinib (Compound)
Topotecan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Topotecan (Compound) upregulates ECH1 (G... |
DB08881 | DB11932 | 868 | 327 | [
"DDInter1925",
"DDInter3"
] | Vemurafenib | Abametapir (topical) | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
868,
24,
327
]
],
[
[
868,
25,
124
],
[
124,
63,
327
]
],
[
[
868,
62,
168
],
[
168,
24,
327
]
],
[
[
868,
63,
613
],
[
613,
24,... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
],
[
"Glasdegib... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Vemurafenib may lead to a major life threatening interaction when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Vemurafenib may cause a m... |
DB00295 | DB01612 | 475 | 1,637 | [
"DDInter1244",
"DDInter92"
] | Morphine | Amyl Nitrite | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
475,
24,
1637
]
],
[
[
475,
25,
946
],
[
946,
24,
1637
]
],
[
[
475,
25,
180
],
[
180,
63,
1637
]
],
[
[
475,
24,
413
],
[
413,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Buspirone"
],
[
"Buspirone",
... | Morphine may lead to a major life threatening interaction when taken with Buspirone and Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Morphine may lead to a major life threatening interaction when taken with Oliceridine and Oliceridine may cause a moderate intera... |
DB00731 | DB01238 | 1,144 | 673 | [
"DDInter1269",
"DDInter118"
] | Nateglinide | Aripiprazole | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
1144,
24,
673
]
],
[
[
1144,
24,
1630
],
[
1630,
1,
673
]
],
[
[
1144,
6,
21998
],
[
21998,
45,
673
]
],
[
[
1144,
21,
28792
],
[
2879... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Compound)
Nateglinide (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Aripiprazole (Compound)
Nateglinide (Compound) causes Gastroin... |
DB00455 | DB12332 | 1,601 | 1,619 | [
"DDInter1091",
"DDInter1626"
] | Loratadine | Rucaparib | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1601,
24,
1619
]
],
[
[
1601,
23,
307
],
[
307,
23,
1619
]
],
[
[
1601,
24,
1419
],
[
1419,
24,
1619
]
],
[
[
1601,
24,
159
],
[
159,
... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Loratadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Modafinil"
],
[
... | Loratadine may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may ca... |
DB06688 | DB08908 | 1,430 | 713 | [
"DDInter1677",
"DDInter564"
] | Sipuleucel-T | Dimethyl fumarate | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1430,
24,
713
]
],
[
[
1430,
63,
1083
],
[
1083,
24,
713
]
],
[
[
1430,
24,
725
],
[
725,
63,
713
]
],
[
[
1430,
24,
36
],
[
36,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Satral... |
DB01095 | DB08871 | 671 | 36 | [
"DDInter769",
"DDInter666"
] | Fluvastatin | Eribulin | Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to r... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
671,
24,
36
]
],
[
[
671,
18,
16974
],
[
16974,
45,
36
]
],
[
[
671,
63,
1488
],
[
1488,
24,
36
]
],
[
[
671,
24,
973
],
[
973,
... | [
[
[
"Fluvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Fluvastatin",
"{u} (Compound) downregulates {v} (Gene)",
"TUBB6"
],
[
"TUBB6",
"{u} (Gene) is bound by {v} (Compo... | Fluvastatin (Compound) downregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Eribulin (Compound)
Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Fluvastatin ... |
DB00683 | DB00877 | 1,382 | 629 | [
"DDInter1212",
"DDInter1678"
] | Midazolam | Sirolimus | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1382,
24,
629
]
],
[
[
1382,
6,
4973
],
[
4973,
45,
629
]
],
[
[
1382,
21,
28898
],
[
28898,
60,
629
]
],
[
[
1382,
24,
1476
],
[
1476... | [
[
[
"Midazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Midazolam",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Midazolam (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Midazolam (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Sirolimus (Compound)
Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Briga... |
DB00434 | DB01100 | 13 | 1,568 | [
"DDInter459",
"DDInter1470"
] | Cyproheptadine | Pimozide | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
13,
24,
1568
]
],
[
[
13,
24,
78
],
[
78,
40,
1568
]
],
[
[
13,
6,
4228
],
[
4228,
45,
1568
]
],
[
[
13,
7,
5998
],
[
5998,
46,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Cyproheptadine (Compound) binds HTR2A (Gene) and HTR2A (Gene) is bound by Pimozide (Compound)
Cyproheptadine (Compound) upregulates HMOX1 (Gene) and HMOX1 (Ge... |
DB12001 | DB12130 | 564 | 1,017 | [
"DDInter7",
"DDInter1094"
] | Abemaciclib | Lorlatinib | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
564,
24,
1017
]
],
[
[
564,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
564,
64,
976
],
[
976,
24,
1017
]
],
[
[
564,
63,
139
],
[
139,
... | [
[
[
"Abemaciclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Abemaciclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Abemaciclib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Abemaciclib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may caus... |
DB06207 | DB09038 | 910 | 1,450 | [
"DDInter1667",
"DDInter636"
] | Silodosin | Empagliflozin | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
910,
24,
1450
]
],
[
[
910,
63,
104
],
[
104,
24,
1450
]
],
[
[
910,
24,
1017
],
[
1017,
63,
1450
]
],
[
[
910,
24,
1491
],
[
1491,
... | [
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[... | Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and L... |
DB01069 | DB06603 | 401 | 39 | [
"DDInter1533",
"DDInter1387"
] | Promethazine | Panobinostat | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
401,
25,
39
]
],
[
[
401,
62,
1247
],
[
1247,
23,
39
]
],
[
[
401,
63,
479
],
[
479,
23,
39
]
],
[
[
401,
24,
1627
],
[
1627,
63... | [
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Promethazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"... | Promethazine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Donepez... |
DB00501 | DB12887 | 752 | 1,598 | [
"DDInter380",
"DDInter1750"
] | Cimetidine | Tazemetostat | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
752,
24,
1598
]
],
[
[
752,
63,
608
],
[
608,
23,
1598
]
],
[
[
752,
24,
594
],
[
594,
24,
1598
]
],
[
[
752,
25,
888
],
[
888,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Tazemetostat
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib... |
DB00388 | DB01261 | 1,636 | 170 | [
"DDInter1453",
"DDInter1679"
] | Phenylephrine | Sitagliptin | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1636,
24,
170
]
],
[
[
1636,
21,
28921
],
[
28921,
60,
170
]
],
[
[
1636,
24,
52
],
[
52,
62,
170
]
],
[
[
1636,
24,
1252
],
[
1252,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Phenylephrine",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) ... | Phenylephrine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sitagliptin (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with ... |
DB00867 | DB01169 | 1,052 | 57 | [
"DDInter1606",
"DDInter120"
] | Ritodrine | Arsenic trioxide | Adrenergic beta-agonist used to control premature labor. | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
1052,
25,
57
]
],
[
[
1052,
35,
480
],
[
480,
24,
57
]
],
[
[
1052,
24,
144
],
[
144,
63,
57
]
],
[
[
1052,
24,
455
],
[
455,
24... | [
[
[
"Ritodrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Ritodrine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Ritodrine (Compound) resembles Formoterol (Compound) and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Arsenic trioxide
Ritodrine may cause a moderate interaction that co... |
DB01021 | DB01142 | 674 | 1,264 | [
"DDInter1861",
"DDInter593"
] | Trichlormethiazide | Doxepin | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
674,
24,
1264
]
],
[
[
674,
24,
401
],
[
401,
24,
1264
]
],
[
[
674,
40,
504
],
[
504,
24,
1264
]
],
[
[
674,
24,
659
],
[
659,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Trichlormethiazide (Compound) resembles Hydrochlorothiazide (Compound) and Hydrochlorothiazide may caus... |
DB00444 | DB06636 | 63 | 1,623 | [
"DDInter1765",
"DDInter980"
] | Teniposide | Isavuconazonium | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
63,
24,
1623
]
],
[
[
63,
24,
309
],
[
309,
24,
1623
]
],
[
[
63,
24,
1593
],
[
1593,
63,
1623
]
],
[
[
63,
35,
896
],
[
896,
24... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and... |
DB00719 | DB00726 | 1,219 | 1,164 | [
"DDInter149",
"DDInter1876"
] | Azatadine | Trimipramine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
1219,
24,
1164
]
],
[
[
1219,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
1219,
1,
11450
],
[
11450,
40,
1164
]
],
[
[
1219,
64,
675
],
[
67... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Azatadine (Compound) resembles Mianserin (Compound) and Mianserin (Compound) resembles Trimipramine (Compound)
Azatadine may lead to a major life threateni... |
DB00705 | DB09082 | 441 | 659 | [
"DDInter496",
"DDInter1934"
] | Delavirdine | Vilanterol | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
441,
24,
659
]
],
[
[
441,
24,
1220
],
[
1220,
23,
659
]
],
[
[
441,
63,
1351
],
[
1351,
23,
659
]
],
[
[
441,
64,
175
],
[
175,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and... |
DB00218 | DB06595 | 1,176 | 1,491 | [
"DDInter1247",
"DDInter1214"
] | Moxifloxacin | Midostaurin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
1176,
25,
1491
]
],
[
[
1176,
23,
112
],
[
112,
23,
1491
]
],
[
[
1176,
24,
761
],
[
761,
24,
1491
]
],
[
[
1176,
25,
888
],
[
888,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin an... |
DB00475 | DB00748 | 1,119 | 662 | [
"DDInter355",
"DDInter297"
] | Chlordiazepoxide | Carbinoxamine | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
1119,
24,
662
]
],
[
[
1119,
63,
1594
],
[
1594,
24,
662
]
],
[
[
1119,
1,
11275
],
[
11275,
40,
662
]
],
[
[
1119,
6,
8374
],
[
8374,... | [
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Chlordiazepoxide (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) resembl... |
DB01001 | DB01175 | 688 | 318 | [
"DDInter1632",
"DDInter672"
] | Salbutamol | Escitalopram | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
688,
24,
318
]
],
[
[
688,
63,
1230
],
[
1230,
1,
318
]
],
[
[
688,
6,
8374
],
[
8374,
45,
318
]
],
[
[
688,
21,
29461
],
[
29461,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Salbutamol (Compound) causes Dysmenorrhoea (Side Effect) and D... |
DB00104 | DB06335 | 966 | 761 | [
"DDInter1323",
"DDInter1646"
] | Octreotide | Saxagliptin | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
966,
24,
761
]
],
[
[
966,
21,
28966
],
[
28966,
60,
761
]
],
[
[
966,
24,
122
],
[
122,
24,
761
]
],
[
[
966,
24,
1296
],
[
1296,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Octreotide",
"{u} (Compound) causes {v} (Side Effect)",
"Upper respiratory tract infection"
],
[
"Upper respiratory t... | Octreotide (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a moderate interaction that co... |
DB00313 | DB01156 | 556 | 593 | [
"DDInter1913",
"DDInter252"
] | Valproic acid | Bupropion | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
556,
24,
593
]
],
[
[
556,
6,
3486
],
[
3486,
45,
593
]
],
[
[
556,
21,
29220
],
[
29220,
60,
593
]
],
[
[
556,
23,
752
],
[
752,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Valproic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compou... | Valproic acid (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bupropion (Compound)
Valproic acid (Compound) causes Abdominal pain upper (Side Effect) and Abdominal pain upper (Side Effect) is caused by Bupropion (Compound)
Valproic acid may cause a minor interaction that can limit clinical effects when tak... |
DB00373 | DB01069 | 461 | 401 | [
"DDInter1809",
"DDInter1533"
] | Timolol | Promethazine | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
461,
24,
401
]
],
[
[
461,
24,
1264
],
[
1264,
63,
401
]
],
[
[
461,
24,
104
],
[
104,
24,
401
]
],
[
[
461,
6,
12523
],
[
12523,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
"Do... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine m... |
DB00445 | DB00530 | 322 | 1,195 | [
"DDInter655",
"DDInter667"
] | Epirubicin | Erlotinib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Moderate | 1 | [
[
[
322,
24,
1195
]
],
[
[
322,
25,
1069
],
[
1069,
1,
1195
]
],
[
[
322,
63,
883
],
[
883,
40,
1195
]
],
[
[
322,
5,
11580
],
[
11580,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
],
[
"Vandetanib"... | Epirubicin may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib (Compound) resembles Erlotinib (Compound)
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Erlotinib (Compound)
Epirubicin (Compoun... |
DB00252 | DB09049 | 362 | 1,135 | [
"DDInter1460",
"DDInter1261"
] | Phenytoin | Naloxegol | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Major | 2 | [
[
[
362,
25,
1135
]
],
[
[
362,
25,
1406
],
[
1406,
62,
1135
]
],
[
[
362,
24,
1424
],
[
1424,
23,
1135
]
],
[
[
362,
25,
478
],
[
478,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
],
[
"Neratinib",
"{u} may ca... | Phenytoin may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a minor inter... |
DB06448 | DB06772 | 171 | 310 | [
"DDInter1087",
"DDInter259"
] | Lonafarnib | Cabazitaxel | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
171,
24,
310
]
],
[
[
171,
63,
973
],
[
973,
24,
310
]
],
[
[
171,
24,
868
],
[
868,
63,
310
]
],
[
[
171,
25,
351
],
[
351,
63,... | [
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemu... |
DB01190 | DB01602 | 568 | 339 | [
"DDInter398",
"DDInter159"
] | Clindamycin | Bacampicillin | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal ac... | Minor | 0 | [
[
[
568,
23,
339
]
],
[
[
568,
24,
609
],
[
609,
23,
339
]
],
[
[
568,
63,
1096
],
[
1096,
24,
339
]
],
[
[
568,
24,
1662
],
[
1662,
... | [
[
[
"Clindamycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bacampicillin"
]
],
[
[
"Clindamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Bacampicillin
Clindamycin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenol... |
DB01254 | DB05351 | 1,213 | 101 | [
"DDInter484",
"DDInter519"
] | Dasatinib | Dexlansoprazole | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Major | 2 | [
[
[
1213,
25,
101
]
],
[
[
1213,
25,
256
],
[
256,
62,
101
]
],
[
[
1213,
64,
1479
],
[
1479,
23,
101
]
],
[
[
1213,
25,
1069
],
[
1069,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
"{u} ... | Dasatinib may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Dasatinib may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Acetylsalicylic acid may ca... |
DB00022 | DB00549 | 268 | 522 | [
"DDInter1408",
"DDInter1955"
] | Peginterferon alfa-2b | Zafirlukast | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
268,
24,
522
]
],
[
[
268,
24,
168
],
[
168,
24,
522
]
],
[
[
268,
24,
1488
],
[
1488,
63,
522
]
],
[
[
268,
63,
491
],
[
491,
2... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bort... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00496 | DB01075 | 194 | 1,376 | [
"DDInter480",
"DDInter569"
] | Darifenacin | Diphenhydramine | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
194,
24,
1376
]
],
[
[
194,
63,
128
],
[
128,
24,
1376
]
],
[
[
194,
24,
832
],
[
832,
24,
1376
]
],
[
[
194,
40,
11241
],
[
11241,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Darifenacin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00612 | DB01222 | 1,121 | 617 | [
"DDInter216",
"DDInter246"
] | Bisoprolol | Budesonide | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
1121,
24,
617
]
],
[
[
1121,
63,
251
],
[
251,
1,
617
]
],
[
[
1121,
24,
175
],
[
175,
1,
617
]
],
[
[
1121,
6,
8374
],
[
8374,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
[... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Budesonide... |
DB00557 | DB01069 | 252 | 401 | [
"DDInter895",
"DDInter1533"
] | Hydroxyzine | Promethazine | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
252,
24,
401
]
],
[
[
252,
24,
1264
],
[
1264,
63,
401
]
],
[
[
252,
40,
1321
],
[
1321,
40,
401
]
],
[
[
252,
24,
104
],
[
104,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Hydroxyzine (Compound) resembles Prochlorperazine (Compound) and Prochlorperazine (Compound) resembles Promethazine... |
DB00762 | DB10316 | 613 | 334 | [
"DDInter973",
"DDInter1248"
] | Irinotecan | Mumps virus strain B level jeryl lynn live antigen | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
613,
25,
334
]
],
[
[
613,
64,
1057
],
[
1057,
25,
334
]
],
[
[
613,
25,
908
],
[
908,
25,
334
]
],
[
[
613,
24,
629
],
[
629,
2... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Irinotecan may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Irinotecan may lead to a major life threatening interaction when taken with Golimumab and Golimumab ma... |
DB00738 | DB01254 | 485 | 1,213 | [
"DDInter1420",
"DDInter484"
] | Pentamidine | Dasatinib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
485,
24,
1213
]
],
[
[
485,
7,
2065
],
[
2065,
45,
1213
]
],
[
[
485,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
485,
18,
2947
],
[
2947,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Pentamidine",
"{u} (Compound) upregulates {v} (Gene)",
"SRC"
],
[
"SRC",
"{u} (Gene) is bound by {v} (Compound)"... | Pentamidine (Compound) upregulates SRC (Gene) and SRC (Gene) is bound by Dasatinib (Compound)
Pentamidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Pentamidine (Compound) downregulates DECR1 (Gene) and DECR1 (Gene) is upregulated by Dasatinib (Compound)
Pentamidine (Compound) upr... |
DB00765 | DB01143 | 1,266 | 923 | [
"DDInter1205",
"DDInter65"
] | Metyrosine | Amifostine | An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma. (Martindale, The Extra Pharmacopoeia, 30th ed) | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1266,
24,
923
]
],
[
[
1266,
21,
28681
],
[
28681,
60,
923
]
],
[
[
1266,
40,
1551
],
[
1551,
24,
923
]
],
[
[
1266,
21,
28681
],
[
28... | [
[
[
"Metyrosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Metyrosine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side E... | Metyrosine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Amifostine (Compound)
Metyrosine (Compound) resembles Methyldopa (Compound) and Methyldopa may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Metyrosine (Compound) causes H... |
DB00224 | DB00604 | 215 | 1,425 | [
"DDInter917",
"DDInter385"
] | Indinavir | Cisapride | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Major | 2 | [
[
[
215,
25,
1425
]
],
[
[
215,
24,
883
],
[
883,
1,
1425
]
],
[
[
215,
6,
21998
],
[
21998,
45,
1425
]
],
[
[
215,
18,
2801
],
[
2801,
... | [
[
[
"Indinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisapride"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gefitinib",
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Cisapride (Compound)
Indinavir (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Cisapride (Compound)
Indinavir (Compound) downregulates PUF60 (Gene) and PU... |
DB00726 | DB01087 | 1,164 | 1,520 | [
"DDInter1876",
"DDInter1520"
] | Trimipramine | Primaquine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1164,
24,
1520
]
],
[
[
1164,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
1164,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
1164,
21,
28722
],
[
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Trimipramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
... | Trimipramine may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Trimipramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Trimipramine (Compound) caus... |
DB00857 | DB09054 | 1,387 | 384 | [
"DDInter1768",
"DDInter905"
] | Terbinafine | Idelalisib | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1387,
24,
384
]
],
[
[
1387,
24,
1627
],
[
1627,
62,
384
]
],
[
[
1387,
62,
479
],
[
479,
23,
384
]
],
[
[
1387,
63,
305
],
[
305,
... | [
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Terbinafine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[... | Terbinafine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Terbinafine may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepez... |
DB00241 | DB01229 | 288 | 973 | [
"DDInter257",
"DDInter1377"
] | Butalbital | Paclitaxel | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
288,
24,
973
]
],
[
[
288,
24,
310
],
[
310,
63,
973
]
],
[
[
288,
24,
458
],
[
458,
24,
973
]
],
[
[
288,
23,
752
],
[
752,
24,... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tini... |
DB00990 | DB09098 | 1,547 | 98 | [
"DDInter705",
"DDInter1700"
] | Exemestane | Somatrem | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1547,
24,
98
]
],
[
[
1547,
1,
1573
],
[
1573,
24,
98
]
],
[
[
1547,
63,
690
],
[
690,
24,
98
]
],
[
[
1547,
24,
1375
],
[
1375,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Exemestane",
"{u} (Compound) resembles {v} (Compound)",
"Prednisone"
],
[
"Prednisone",
"{u} may cause a moderate ... | Exemestane (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exa... |
DB00570 | DB10316 | 147 | 334 | [
"DDInter1936",
"DDInter1248"
] | Vinblastine | Mumps virus strain B level jeryl lynn live antigen | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
147,
25,
334
]
],
[
[
147,
64,
1057
],
[
1057,
25,
334
]
],
[
[
147,
24,
328
],
[
328,
25,
334
]
],
[
[
147,
25,
908
],
[
908,
2... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Vinblastine may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptop... |
DB11730 | DB14711 | 351 | 779 | [
"DDInter1588",
"DDInter1680"
] | Ribociclib | Smallpox (Vaccinia) Vaccine, Live | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
351,
25,
779
]
],
[
[
351,
64,
1064
],
[
1064,
25,
779
]
],
[
[
351,
63,
147
],
[
147,
25,
779
]
],
[
[
351,
25,
1259
],
[
1259,
... | [
[
[
"Ribociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Ribociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
"Cl... | Ribociclib may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine ... |
DB00607 | DB12941 | 1,249 | 466 | [
"DDInter1256",
"DDInter481"
] | Nafcillin | Darolutamide | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1249,
24,
466
]
],
[
[
1249,
24,
351
],
[
351,
23,
466
]
],
[
[
1249,
25,
283
],
[
283,
23,
466
]
],
[
[
1249,
24,
159
],
[
159,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Nafcillin may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a ... |
DB00289 | DB09020 | 847 | 28 | [
"DDInter132",
"DDInter212"
] | Atomoxetine | Bisacodyl | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
847,
24,
28
]
],
[
[
847,
18,
1954
],
[
1954,
57,
28
]
],
[
[
847,
21,
28666
],
[
28666,
60,
28
]
],
[
[
847,
24,
823
],
[
823,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Atomoxetine",
"{u} (Compound) downregulates {v} (Gene)",
"COG2"
],
[
"COG2",
"{u} (Gene) is downregulated by {v}... | Atomoxetine (Compound) downregulates COG2 (Gene) and COG2 (Gene) is downregulated by Bisacodyl (Compound)
Atomoxetine (Compound) causes Nervous system disorder (Side Effect) and Nervous system disorder (Side Effect) is caused by Bisacodyl (Compound)
Atomoxetine may cause a moderate interaction that could exacerbate dis... |
DB08870 | DB08907 | 850 | 1,344 | [
"DDInter228",
"DDInter280"
] | Brentuximab vedotin | Canagliflozin | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
850,
24,
1344
]
],
[
[
850,
63,
549
],
[
549,
1,
1344
]
],
[
[
850,
24,
1033
],
[
1033,
63,
1344
]
],
[
[
850,
63,
1523
],
[
1523,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagl... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a modera... |
DB05294 | DB14881 | 1,069 | 180 | [
"DDInter1917",
"DDInter1329"
] | Vandetanib | Oliceridine | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
1069,
25,
180
]
],
[
[
1069,
62,
112
],
[
112,
23,
180
]
],
[
[
1069,
64,
401
],
[
401,
24,
180
]
],
[
[
1069,
25,
124
],
[
124,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Vandetanib may lead to a major life threatening interaction when taken with Promethazine and Promethazine may... |
DB00791 | DB08826 | 132 | 1,292 | [
"DDInter1902",
"DDInter489"
] | Uracil mustard | Deferiprone | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
132,
25,
1292
]
],
[
[
132,
24,
4
],
[
4,
25,
1292
]
],
[
[
132,
64,
1064
],
[
1064,
25,
1292
]
],
[
[
132,
63,
597
],
[
597,
25... | [
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
],... | Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Deferiprone
Uracil mustard may lead to a major life threatening interaction when taken with Cladribine a... |
DB00960 | DB09134 | 887 | 1,552 | [
"DDInter1471",
"DDInter966"
] | Pindolol | Ioversol | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
887,
24,
1552
]
],
[
[
887,
1,
819
],
[
819,
24,
1552
]
],
[
[
887,
40,
726
],
[
726,
24,
1552
]
],
[
[
887,
63,
1648
],
[
1648,
... | [
[
[
"Pindolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Pindolol",
"{u} (Compound) resembles {v} (Compound)",
"Acebutolol"
],
[
"Acebutolol",
"{u} may cause a moderate inte... | Pindolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Pindolol (Compound) resembles Betaxolol (Compound) and Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Pindolol m... |
DB04896 | DB06228 | 901 | 792 | [
"DDInter1220",
"DDInter1609"
] | Milnacipran | Rivaroxaban | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
901,
24,
792
]
],
[
[
901,
18,
5901
],
[
5901,
57,
792
]
],
[
[
901,
21,
28703
],
[
28703,
60,
792
]
],
[
[
901,
40,
41
],
[
41,
... | [
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Milnacipran",
"{u} (Compound) downregulates {v} (Gene)",
"GJA1"
],
[
"GJA1",
"{u} (Gene) is downregulated by {... | Milnacipran (Compound) downregulates GJA1 (Gene) and GJA1 (Gene) is downregulated by Rivaroxaban (Compound)
Milnacipran (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Milnacipran (Compound) resembles Levomilnacipran (Compound) and Levo
Milnacipran may lead to a m... |
DB00631 | DB01098 | 372 | 14 | [
"DDInter405",
"DDInter1622"
] | Clofarabine | Rosuvastatin | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
372,
24,
14
]
],
[
[
372,
24,
671
],
[
671,
24,
14
]
],
[
[
372,
6,
17404
],
[
17404,
45,
14
]
],
[
[
372,
18,
1917
],
[
1917,
4... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Rosuvastatin (Compound)
Clofarabine ... |
DB00146 | DB06723 | 160 | 115 | [
"DDInter265",
"DDInter58"
] | Calcifediol | Aluminum hydroxide | The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties. | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
160,
24,
115
]
],
[
[
160,
24,
1482
],
[
1482,
23,
115
]
],
[
[
160,
24,
463
],
[
463,
24,
115
]
],
[
[
160,
25,
1041
],
[
1041,
... | [
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Calcifediol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],... | Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxide
Calcifediol may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and ... |
DB00603 | DB00877 | 303 | 629 | [
"DDInter1137",
"DDInter1678"
] | Medroxyprogesterone acetate | Sirolimus | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
303,
24,
629
]
],
[
[
303,
6,
8374
],
[
8374,
45,
629
]
],
[
[
303,
7,
3932
],
[
3932,
46,
629
]
],
[
[
303,
18,
1870
],
[
1870,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (G... | Medroxyprogesterone acetate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Medroxyprogesterone acetate (Compound) upregulates FOXO3 (Gene) and FOXO3 (Gene) is upregulated by Sirolimus (Compound)
Medroxyprogesterone acetate (Compound) downregulates MYC (Gene) and MYC (Gene) is upregula... |
DB00899 | DB01114 | 411 | 272 | [
"DDInter1579",
"DDInter362"
] | Remifentanil | Chlorpheniramine | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
411,
24,
272
]
],
[
[
411,
24,
849
],
[
849,
63,
272
]
],
[
[
411,
63,
128
],
[
128,
24,
272
]
],
[
[
411,
21,
28898
],
[
28898,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]... | Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphen... |
DB00047 | DB01015 | 176 | 1,247 | [
"DDInter932",
"DDInter1724"
] | Insulin glargine | Sulfamethoxazole | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Moderate | 1 | [
[
[
176,
24,
1247
]
],
[
[
176,
24,
1029
],
[
1029,
1,
1247
]
],
[
[
176,
24,
688
],
[
688,
23,
1247
]
],
[
[
176,
24,
1487
],
[
1487,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfisoxa... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound)
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a minor i... |
DB00445 | DB11642 | 322 | 938 | [
"DDInter655",
"DDInter1480"
] | Epirubicin | Pitolisant | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
322,
24,
938
]
],
[
[
322,
23,
112
],
[
112,
23,
938
]
],
[
[
322,
63,
600
],
[
600,
24,
938
]
],
[
[
322,
24,
1228
],
[
1228,
2... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flu... |
DB00014 | DB00333 | 521 | 576 | [
"DDInter839",
"DDInter1166"
] | Goserelin | Methadone | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Major | 2 | [
[
[
521,
25,
576
]
],
[
[
521,
25,
494
],
[
494,
40,
576
]
],
[
[
521,
24,
847
],
[
847,
40,
576
]
],
[
[
521,
24,
1164
],
[
1164,
1... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methadone"
]
],
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Disopyramide"
],
[
"Disopyramide",
"{u} ... | Goserelin may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Methadone (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Methadone (Compound)
Goserelin may... |
DB00701 | DB06603 | 1,091 | 39 | [
"DDInter90",
"DDInter1387"
] | Amprenavir | Panobinostat | Amprenavir is a protease inhibitor used to treat HIV infection. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
1091,
24,
39
]
],
[
[
1091,
25,
112
],
[
112,
23,
39
]
],
[
[
1091,
25,
455
],
[
455,
24,
39
]
],
[
[
1091,
24,
578
],
[
578,
63... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metronidazole"
],
[
"Metro... | Amprenavir may lead to a major life threatening interaction when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Amprenavir may lead to a major life threatening interaction when taken with Salmeterol and Salmeterol may cause a moderat... |
DB01101 | DB11601 | 60 | 1,270 | [
"DDInter285",
"DDInter1889"
] | Capecitabine | Tuberculin purified protein derivative | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
60,
24,
1270
]
],
[
[
60,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
60,
63,
869
],
[
869,
24,
1270
]
],
[
[
60,
64,
1064
],
[
1064,
... | [
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Capecitabine may cause a moderate interaction that could exacerbate diseases whe... |
DB00694 | DB08903 | 51 | 996 | [
"DDInter485",
"DDInter170"
] | Daunorubicin | Bedaquiline | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
51,
25,
996
]
],
[
[
51,
6,
8374
],
[
8374,
45,
996
]
],
[
[
51,
21,
29282
],
[
29282,
60,
996
]
],
[
[
51,
23,
112
],
[
112,
23... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Daunorubicin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Be... | Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Daunorubicin (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Bedaquiline (Compound)
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazo... |
DB00501 | DB00862 | 752 | 1,005 | [
"DDInter380",
"DDInter1918"
] | Cimetidine | Vardenafil | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Moderate | 1 | [
[
[
752,
24,
1005
]
],
[
[
752,
6,
8374
],
[
8374,
45,
1005
]
],
[
[
752,
21,
28658
],
[
28658,
60,
1005
]
],
[
[
752,
23,
112
],
[
112,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vardenafil"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vardenafil (Compound)
Cimetidine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Vardenafil (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metro... |
DB00561 | DB00983 | 1,048 | 480 | [
"DDInter591",
"DDInter776"
] | Doxapram | Formoterol | A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225) | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
1048,
24,
480
]
],
[
[
1048,
24,
1148
],
[
1148,
63,
480
]
],
[
[
1048,
21,
28963
],
[
28963,
60,
480
]
],
[
[
1048,
25,
1053
],
[
105... | [
[
[
"Doxapram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Doxapram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Doxapram may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Doxapram (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Formoterol (Compound)
... |
DB01118 | DB09156 | 33 | 777 | [
"DDInter76",
"DDInter964"
] | Amiodarone | Iopromide | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
33,
24,
777
]
],
[
[
33,
24,
1074
],
[
1074,
63,
777
]
],
[
[
33,
25,
116
],
[
116,
63,
777
]
],
[
[
33,
63,
372
],
[
372,
25,
... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
],
[
... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Iodide I-123 may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Amiodarone may lead to a major life threatening interaction when taken with Iodide I-131 and Iodide I-131 may... |
DB06694 | DB06700 | 31 | 643 | [
"DDInter1952",
"DDInter511"
] | Xylometazoline (nasal) | Desvenlafaxine | Xylometazoline is an alkylbenzene. | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
31,
24,
643
]
],
[
[
31,
63,
1100
],
[
1100,
1,
643
]
],
[
[
31,
63,
1674
],
[
1674,
24,
643
]
],
[
[
31,
24,
144
],
[
144,
63,
... | [
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Xylometazoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
... | Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine
Xylometazoline may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Xylometazoline may cause a moderate inte... |
DB00377 | DB00934 | 1,494 | 413 | [
"DDInter1382",
"DDInter1124"
] | Palonosetron | Maprotiline | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Major | 2 | [
[
[
1494,
25,
413
]
],
[
[
1494,
64,
1302
],
[
1302,
40,
413
]
],
[
[
1494,
63,
847
],
[
847,
1,
413
]
],
[
[
1494,
6,
7950
],
[
7950,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Maprotiline"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Protriptyline"
],
[
"Protriptyline",
... | Palonosetron may lead to a major life threatening interaction when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Maprotiline (Compound)
P... |
DB00153 | DB01377 | 1,331 | 1,283 | [
"DDInter662",
"DDInter1119"
] | Ergocalciferol | Magnesium oxide | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
1331,
24,
1283
]
],
[
[
1331,
24,
1252
],
[
1252,
23,
1283
]
],
[
[
1331,
24,
1482
],
[
1482,
62,
1283
]
],
[
[
1331,
23,
752
],
[
752... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
]... | Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Ergocalciferol may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Di... |
DB06688 | DB09036 | 1,430 | 812 | [
"DDInter1677",
"DDInter1668"
] | Sipuleucel-T | Siltuximab | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
1430,
24,
812
]
],
[
[
1430,
24,
287
],
[
287,
63,
812
]
],
[
[
1430,
63,
147
],
[
147,
24,
812
]
],
[
[
1430,
24,
713
],
[
713,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate and Diroximel fumarate may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with V... |
DB00563 | DB08864 | 663 | 786 | [
"DDInter1174",
"DDInter1595"
] | Methotrexate | Rilpivirine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
663,
24,
786
]
],
[
[
663,
6,
17404
],
[
17404,
45,
786
]
],
[
[
663,
21,
28734
],
[
28734,
60,
786
]
],
[
[
663,
63,
522
],
[
522,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound... | Methotrexate (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Rilpivirine (Compound)
Methotrexate (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Rilpivirine (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases whe... |
DB06077 | DB11130 | 879 | 407 | [
"DDInter1102",
"DDInter1344"
] | Lumateperone | Opium | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
879,
24,
407
]
],
[
[
879,
63,
662
],
[
662,
24,
407
]
],
[
[
879,
24,
849
],
[
849,
24,
407
]
],
[
[
879,
64,
475
],
[
475,
24,... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and M... |
DB01575 | DB11943 | 1,054 | 255 | [
"DDInter1005",
"DDInter495"
] | Kaolin | Delafloxacin | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
1054,
24,
255
]
],
[
[
1054,
62,
17
],
[
17,
62,
417
],
[
417,
24,
255
]
],
[
[
1054,
62,
772
],
[
772,
23,
1283
],
[
1283,
24,
... | [
[
[
"Kaolin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Kaolin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sotalol"
],
[
"Sotalo... | Kaolin may cause a minor interaction that can limit clinical effects when taken with Sotalol and Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Kaolin may cause a... |
DB08912 | DB15233 | 1,040 | 1,650 | [
"DDInter462",
"DDInter142"
] | Dabrafenib | Avapritinib | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
1040,
25,
1650
]
],
[
[
1040,
63,
1478
],
[
1478,
24,
1650
]
],
[
[
1040,
62,
1101
],
[
1101,
24,
1650
]
],
[
[
1040,
24,
159
],
[
159... | [
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor"... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Dabrafenib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexaroten... |
DB00261 | DB01599 | 702 | 1,232 | [
"DDInter93",
"DDInter1523"
] | Anagrelide | Probucol | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Major | 2 | [
[
[
702,
25,
1232
]
],
[
[
702,
23,
112
],
[
112,
23,
1232
]
],
[
[
702,
25,
1555
],
[
1555,
24,
1232
]
],
[
[
702,
25,
927
],
[
927,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Probucol"
]
],
[
[
"Anagrelide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Anagrelide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol
Anagrelide may lead to a major life threatening interaction when taken with Oxaliplatin and Oxaliplatin may caus... |
DB04938 | DB09065 | 1,423 | 760 | [
"DDInter1353",
"DDInter424"
] | Ospemifene | Cobicistat | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1423,
24,
760
]
],
[
[
1423,
63,
609
],
[
609,
24,
760
]
],
[
[
1423,
24,
384
],
[
384,
24,
760
]
],
[
[
1423,
74,
888
],
[
888,
... | [
[
[
"Ospemifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Ospemifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib an... |
DB00188 | DB11817 | 168 | 1,259 | [
"DDInter222",
"DDInter165"
] | Bortezomib | Baricitinib | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
168,
25,
1259
]
],
[
[
168,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
168,
24,
949
],
[
949,
24,
1259
]
],
[
[
168,
24,
1129
],
[
1129,
... | [
[
[
"Bortezomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoi... |
DB01064 | DB13928 | 1,148 | 1,385 | [
"DDInter987",
"DDInter1660"
] | Isoprenaline | Semaglutide | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1148,
24,
1385
]
],
[
[
1148,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
1148,
24,
1399
],
[
1399,
63,
1385
]
],
[
[
1148,
64,
839
],
[
839... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"Pasi... | Isoprenaline may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate and Lithium... |
DB00470 | DB00673 | 530 | 723 | [
"DDInter601",
"DDInter112"
] | Dronabinol | Aprepitant | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Moderate | 1 | [
[
[
530,
24,
723
]
],
[
[
530,
24,
875
],
[
875,
40,
723
]
],
[
[
530,
6,
8374
],
[
8374,
45,
723
]
],
[
[
530,
21,
28936
],
[
28936,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
],
[... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Fosaprepitant and Fosaprepitant (Compound) resembles Aprepitant (Compound)
Dronabinol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Aprepitant (Compound)
Dronabinol (Compound) causes Hyperhidrosis (Side Effect) and... |
DB01001 | DB01601 | 688 | 833 | [
"DDInter1632",
"DDInter1089"
] | Salbutamol | Lopinavir | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Moderate | 1 | [
[
[
688,
24,
833
]
],
[
[
688,
24,
1327
],
[
1327,
40,
833
]
],
[
[
688,
6,
8374
],
[
8374,
45,
833
]
],
[
[
688,
24,
549
],
[
549,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Saquinavir and Saquinavir (Compound) resembles Lopinavir (Compound)
Salbutamol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lopinavir (Compound)
Salbutamol may cause a moderate interaction that could exacerbate di... |
DB00476 | DB01611 | 109 | 1,487 | [
"DDInter608",
"DDInter893"
] | Duloxetine | Hydroxychloroquine | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
109,
24,
1487
]
],
[
[
109,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
109,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
109,
21,
28658
],
[
2865... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Duloxetine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Duloxetine (Compo... |
DB00526 | DB12332 | 1,555 | 1,619 | [
"DDInter1355",
"DDInter1626"
] | Oxaliplatin | Rucaparib | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1555,
24,
1619
]
],
[
[
1555,
24,
112
],
[
112,
23,
1619
]
],
[
[
1555,
24,
259
],
[
259,
24,
1619
]
],
[
[
1555,
24,
151
],
[
151,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and R... |
DB00254 | DB01396 | 964 | 1,482 | [
"DDInter598",
"DDInter553"
] | Doxycycline | Digitoxin | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
964,
24,
1482
]
],
[
[
964,
24,
1252
],
[
1252,
1,
1482
]
],
[
[
964,
6,
8374
],
[
8374,
45,
1482
]
],
[
[
964,
24,
1283
],
[
1283,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Doxycycline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Digitoxin (Compound)
Doxycycline may cause a moderate interaction that could exacerbate disea... |
DB00220 | DB01110 | 798 | 86 | [
"DDInter1276",
"DDInter1209"
] | Nelfinavir | Miconazole | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
798,
24,
86
]
],
[
[
798,
6,
10215
],
[
10215,
45,
86
]
],
[
[
798,
18,
2183
],
[
2183,
57,
86
]
],
[
[
798,
21,
29388
],
[
29388,
... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)... | Nelfinavir (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Miconazole (Compound)
Nelfinavir (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Miconazole (Compound)
Nelfinavir (Compound) causes Mouth ulceration (Side Effect) and Mouth ulceration (Side Effect) is caused by Miconazo... |
DB01166 | DB01224 | 477 | 623 | [
"DDInter379",
"DDInter1553"
] | Cilostazol | Quetiapine | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
477,
24,
623
]
],
[
[
477,
63,
827
],
[
827,
1,
623
]
],
[
[
477,
64,
851
],
[
851,
1,
623
]
],
[
[
477,
6,
12523
],
[
12523,
45... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Cilostazol may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone (Compound) resembles Quetiapine (Compound)
Cilostazol (Compo... |
DB00030 | DB01611 | 1,685 | 1,487 | [
"DDInter934",
"DDInter893"
] | Insulin human | Hydroxychloroquine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
1685,
24,
1487
]
],
[
[
1685,
24,
1247
],
[
1247,
23,
1487
]
],
[
[
1685,
24,
168
],
[
168,
24,
1487
]
],
[
[
1685,
63,
521
],
[
521,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxaz... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Hydroxychloroquine
Insulin human may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00986 | DB01403 | 1,192 | 9 | [
"DDInter834",
"DDInter1175"
] | Glycopyrronium | Methotrimeprazine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1192,
24,
9
]
],
[
[
1192,
63,
1178
],
[
1178,
40,
9
]
],
[
[
1192,
63,
1164
],
[
1164,
1,
9
]
],
[
[
1192,
24,
401
],
[
401,
24... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperaz... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) res... |
DB00213 | DB14006 | 837 | 972 | [
"DDInter1388",
"DDInter370"
] | Pantoprazole | Choline salicylate | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Minor | 0 | [
[
[
837,
23,
972
]
],
[
[
837,
1,
660
],
[
660,
23,
972
]
],
[
[
837,
24,
1347
],
[
1347,
24,
972
]
],
[
[
837,
23,
256
],
[
256,
24... | [
[
[
"Pantoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Choline salicylate"
]
],
[
[
"Pantoprazole",
"{u} (Compound) resembles {v} (Compound)",
"Esomeprazole"
],
[
"Esomeprazole",
"{u} may c... | Pantoprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Choline salicylate
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may cause a moderate intera... |
DB00741 | DB00794 | 167 | 759 | [
"DDInter885",
"DDInter1521"
] | Hydrocortisone | Primidone | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
167,
24,
759
]
],
[
[
167,
24,
697
],
[
697,
40,
759
]
],
[
[
167,
63,
362
],
[
362,
1,
759
]
],
[
[
167,
24,
157
],
[
157,
1,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (... |
DB01200 | DB04837 | 469 | 649 | [
"DDInter243",
"DDInter407"
] | Bromocriptine | Clofedanol | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
469,
24,
649
]
],
[
[
469,
63,
1376
],
[
1376,
24,
649
]
],
[
[
469,
63,
832
],
[
832,
40,
649
]
],
[
[
469,
62,
888
],
[
888,
4... | [
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Tripe... |
DB05528 | DB05773 | 1,070 | 1,047 | [
"DDInter1228",
"DDInter1848"
] | Mipomersen | Trastuzumab emtansine | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Major | 2 | [
[
[
1070,
25,
1047
]
],
[
[
1070,
64,
848
],
[
848,
24,
1047
]
],
[
[
1070,
25,
1593
],
[
1593,
63,
1047
]
],
[
[
1070,
25,
292
],
[
292,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibuprofen"
],
[
"Ibuprofen",
... | Mipomersen may lead to a major life threatening interaction when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Mipomersen may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a mode... |
DB06605 | DB08875 | 1,409 | 1,618 | [
"DDInter108",
"DDInter262"
] | Apixaban | Cabozantinib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1409,
25,
1618
]
],
[
[
1409,
63,
723
],
[
723,
24,
1618
]
],
[
[
1409,
24,
384
],
[
384,
63,
1618
]
],
[
[
1409,
62,
307
],
[
307,
... | [
[
[
"Apixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
"Aprepitant",... | Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalis... |
DB00372 | DB09045 | 999 | 52 | [
"DDInter1793",
"DDInter607"
] | Thiethylperazine | Dulaglutide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
999,
24,
52
]
],
[
[
999,
24,
170
],
[
170,
23,
52
]
],
[
[
999,
24,
178
],
[
178,
24,
52
]
],
[
[
999,
63,
73
],
[
73,
24,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Polythia... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.