drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00619 | DB04951 | 1,419 | 187 | [
"DDInter909",
"DDInter1477"
] | Imatinib | Pirfenidone | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
1419,
24,
187
]
],
[
[
1419,
25,
1670
],
[
1670,
63,
187
]
],
[
[
1419,
63,
92
],
[
92,
24,
187
]
],
[
[
1419,
24,
637
],
[
637,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
],
[
"Eliglustat",
... | Imatinib may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Methoxsalen and Methoxsalen may cause a... |
DB00358 | DB11979 | 1,010 | 1,320 | [
"DDInter1140",
"DDInter625"
] | Mefloquine | Elagolix | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1010,
24,
1320
]
],
[
[
1010,
63,
608
],
[
608,
23,
1320
]
],
[
[
1010,
24,
1612
],
[
1612,
23,
1320
]
],
[
[
1010,
24,
1297
],
[
1297... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Elagolix
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir... |
DB00076 | DB00477 | 1,352 | 216 | [
"DDInter555",
"DDInter363"
] | Digoxin Immune Fab (Ovine) | Chlorpromazine | Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin. | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Moderate | 1 | [
[
[
1352,
24,
216
]
],
[
[
1352,
24,
1178
],
[
1178,
1,
216
]
],
[
[
1352,
24,
684
],
[
684,
40,
216
]
],
[
[
1352,
25,
57
],
[
57,
... | [
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpromazine"
]
],
[
[
"Digoxin Immune Fab (Ovine)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Digoxin Immune Fab (Ovine) may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Chlorpromazine (Compound)
Digoxin Immune Fab (Ovine) may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thiori... |
DB01211 | DB08827 | 609 | 990 | [
"DDInter393",
"DDInter1085"
] | Clarithromycin | Lomitapide | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
609,
25,
990
]
],
[
[
609,
64,
1080
],
[
1080,
1,
990
]
],
[
[
609,
6,
8374
],
[
8374,
45,
990
]
],
[
[
609,
54,
19133
],
[
19133,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",
... | Clarithromycin may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Clarithromycin (Compound) is included by P-Glycoprotein Inhibitors (Pharm... |
DB00366 | DB01181 | 1,594 | 1,532 | [
"DDInter600",
"DDInter906"
] | Doxylamine | Ifosfamide | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
1594,
24,
1532
]
],
[
[
1594,
21,
28956
],
[
28956,
60,
1532
]
],
[
[
1594,
63,
1648
],
[
1648,
24,
1532
]
],
[
[
1594,
24,
684
],
[
6... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Doxylamine",
"{u} (Compound) causes {v} (Side Effect)",
"Palpitations"
],
[
"Palpitations",
"{u} (Side Effect) i... | Doxylamine (Compound) causes Palpitations (Side Effect) and Palpitations (Side Effect) is caused by Ifosfamide (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00352 | DB01149 | 482 | 851 | [
"DDInter1814",
"DDInter1274"
] | Tioguanine | Nefazodone | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
482,
24,
851
]
],
[
[
482,
21,
29544
],
[
29544,
60,
851
]
],
[
[
482,
63,
1101
],
[
1101,
23,
851
]
],
[
[
482,
24,
1374
],
[
1374,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Weight increased"
],
[
"Weight increased",
"{u} (Side E... | Tioguanine (Compound) causes Weight increased (Side Effect) and Weight increased (Side Effect) is caused by Nefazodone (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken ... |
DB01124 | DB01138 | 1,411 | 804 | [
"DDInter1828",
"DDInter1726"
] | Tolbutamide | Sulfinpyrazone | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
1411,
24,
804
]
],
[
[
1411,
63,
998
],
[
998,
1,
804
]
],
[
[
1411,
6,
3486
],
[
3486,
45,
804
]
],
[
[
1411,
63,
168
],
[
168,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
]... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Tolbutamide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sulfinpyrazone (Compound)
Tolbutamide may cause a moderate interaction tha... |
DB00427 | DB11130 | 1,233 | 407 | [
"DDInter1879",
"DDInter1344"
] | Triprolidine | Opium | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1233,
24,
407
]
],
[
[
1233,
63,
558
],
[
558,
24,
407
]
],
[
[
1233,
24,
1190
],
[
1190,
24,
407
]
],
[
[
1233,
24,
418
],
[
418,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
],
[
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Zolpidem and Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Opium
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Ketamine and Ketamine may ... |
DB00496 | DB00857 | 194 | 1,387 | [
"DDInter480",
"DDInter1768"
] | Darifenacin | Terbinafine | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
194,
24,
1387
]
],
[
[
194,
6,
8374
],
[
8374,
45,
1387
]
],
[
[
194,
7,
10269
],
[
10269,
46,
1387
]
],
[
[
194,
21,
28847
],
[
28847... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Darifenacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Darifenacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Terbinafine (Compound)
Darifenacin (Compound) upregulates DHX29 (Gene) and DHX29 (Gene) is upregulated by Terbinafine (Compound)
Darifenacin (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Terbinafine (Comp... |
DB00902 | DB06204 | 104 | 768 | [
"DDInter1168",
"DDInter1746"
] | Methdilazine | Tapentadol | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Moderate | 1 | [
[
[
104,
24,
768
]
],
[
[
104,
63,
1123
],
[
1123,
24,
768
]
],
[
[
104,
24,
1383
],
[
1383,
63,
768
]
],
[
[
104,
24,
1532
],
[
1532,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tapentadol"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulf... |
DB00099 | DB14509 | 440 | 1,399 | [
"DDInter735",
"DDInter1081"
] | Filgrastim | Lithium carbonate | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
440,
24,
1399
]
],
[
[
440,
24,
589
],
[
589,
23,
1399
]
],
[
[
440,
24,
1555
],
[
1555,
24,
1399
]
],
[
[
440,
24,
351
],
[
351,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
],
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Ox... |
DB00812 | DB14723 | 998 | 159 | [
"DDInter1451",
"DDInter1026"
] | Phenylbutazone | Larotrectinib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
998,
24,
159
]
],
[
[
998,
24,
222
],
[
222,
23,
159
]
],
[
[
998,
24,
741
],
[
741,
24,
159
]
],
[
[
998,
40,
307
],
[
307,
24,... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
... | Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant... |
DB00457 | DB01285 | 1,205 | 708 | [
"DDInter1511",
"DDInter445"
] | Prazosin | Corticotropin | Prazosin is a drug used to treat hypertension. Prazosin is marketed by _Pfizer_ and was initially approved by the FDA in 1988. It belongs to the class of drugs known as alpha-1 antagonists. Recently, many studies have evaluated the benefits of this drug in controlling the symptoms of post-traumatic stress disorder (PTS... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1205,
24,
708
]
],
[
[
1205,
24,
1450
],
[
1450,
63,
708
]
],
[
[
1205,
40,
1433
],
[
1433,
24,
708
]
],
[
[
1205,
63,
1648
],
[
1648,... | [
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Prazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[
... | Prazosin may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Prazosin (Compound) resembles Doxazosin (Compound) and Doxazosin may cause a moderate interaction that co... |
DB00514 | DB00832 | 506 | 499 | [
"DDInter527",
"DDInter1446"
] | Dextromethorphan | Phensuximide | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Phensuximide is a member of the succinimide class with anticonvulsant properties. It suppresses the paroxysmal three cycle per second spike and wave EEG pattern associated with lapses of consciousness in petit mal seizures. The frequency of attacks is reduced by depression of nerve transmission in the motor cortex. | Moderate | 1 | [
[
[
506,
24,
499
]
],
[
[
506,
63,
902
],
[
902,
40,
499
]
],
[
[
506,
24,
157
],
[
157,
40,
499
]
],
[
[
506,
6,
10215
],
[
10215,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phensuximide"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clobazam"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Phensuximide (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin and Ethotoin (Compound) resembles Phensuximide (Co... |
DB01045 | DB05294 | 463 | 1,069 | [
"DDInter1590",
"DDInter1917"
] | Rifampicin | Vandetanib | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Moderate | 1 | [
[
[
463,
24,
1069
]
],
[
[
463,
63,
1195
],
[
1195,
40,
1069
]
],
[
[
463,
6,
10417
],
[
10417,
45,
1069
]
],
[
[
463,
25,
1135
],
[
1135,... | [
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Rifampicin (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Vandetanib (Compound)
Rifampicin may lead to a major life threatening interaction when taken... |
DB00808 | DB00910 | 1,605 | 1,041 | [
"DDInter916",
"DDInter1394"
] | Indapamide | Paricalcitol | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Moderate | 1 | [
[
[
1605,
24,
1041
]
],
[
[
1605,
63,
386
],
[
386,
25,
1041
]
],
[
[
1605,
24,
1098
],
[
1098,
64,
1041
]
],
[
[
1605,
6,
8374
],
[
8374,... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paricalcitol"
]
],
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
],
... | Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Paricalcitol
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Dihydrotachysterol and D... |
DB00074 | DB06372 | 1,309 | 259 | [
"DDInter166",
"DDInter1594"
] | Basiliximab | Rilonacept | A recombinant chimeric (murine/human) monoclonal antibody (IgG1k) that functions as an immunosuppressive agent, specifically binding to and blocking the interleukin-2 receptor a-chain (IL-2R alpha, also known as CD25 antigen) on the surface of activated T-lymphocytes. It is a 144 kDa glycoprotein obtained from fermenta... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
1309,
24,
259
]
],
[
[
1309,
23,
1114
],
[
1114,
62,
259
]
],
[
[
1309,
23,
1461
],
[
1461,
23,
259
]
],
[
[
1309,
24,
1367
],
[
1367,... | [
[
[
"Basiliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Basiliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Basiliximab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Basiliximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin... |
DB04865 | DB10276 | 4 | 1,624 | [
"DDInter1335",
"DDInter1623"
] | Omacetaxine mepesuccinate | Rotavirus vaccine | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
4,
25,
1624
]
],
[
[
4,
63,
617
],
[
617,
24,
1624
]
],
[
[
4,
63,
552
],
[
552,
25,
1624
]
],
[
[
4,
24,
1583
],
[
1583,
64,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budes... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Rotavirus vaccine
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases ... |
DB01001 | DB11986 | 688 | 484 | [
"DDInter1632",
"DDInter648"
] | Salbutamol | Entrectinib | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
688,
24,
484
]
],
[
[
688,
23,
1247
],
[
1247,
23,
484
]
],
[
[
688,
62,
112
],
[
112,
23,
484
]
],
[
[
688,
24,
222
],
[
222,
2... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Salbutamol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Salbutamol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole ... |
DB00313 | DB09104 | 556 | 286 | [
"DDInter1913",
"DDInter1118"
] | Valproic acid | Magnesium hydroxide | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
556,
23,
286
]
],
[
[
556,
24,
820
],
[
820,
23,
286
]
],
[
[
556,
23,
752
],
[
752,
23,
286
]
],
[
[
556,
24,
1487
],
[
1487,
2... | [
[
[
"Valproic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Valproic acid may cause a minor interaction that can limit clinical effects when taken with Cimetidi... |
DB00927 | DB01044 | 1,559 | 246 | [
"DDInter712",
"DDInter809"
] | Famotidine | Gatifloxacin | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Moderate | 1 | [
[
[
1559,
24,
246
]
],
[
[
1559,
24,
739
],
[
739,
1,
246
]
],
[
[
1559,
63,
1176
],
[
1176,
1,
246
]
],
[
[
1559,
24,
945
],
[
945,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin... |
DB00619 | DB06212 | 1,419 | 165 | [
"DDInter909",
"DDInter1833"
] | Imatinib | Tolvaptan | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
1419,
24,
165
]
],
[
[
1419,
24,
1080
],
[
1080,
1,
165
]
],
[
[
1419,
63,
522
],
[
522,
1,
165
]
],
[
[
1419,
6,
8374
],
[
8374,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Tolvaptan (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast (Compound) resembles Tolvaptan (Compound)
Imat... |
DB01583 | DB09481 | 624 | 460 | [
"DDInter1075",
"DDInter1113"
] | Liotrix | Magnesium carbonate | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
624,
24,
460
]
],
[
[
624,
63,
245
],
[
245,
24,
460
]
],
[
[
624,
24,
428
],
[
428,
63,
460
]
],
[
[
624,
24,
1596
],
[
1596,
2... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium carbonate
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate... |
DB00382 | DB09054 | 62 | 384 | [
"DDInter1734",
"DDInter905"
] | Tacrine | Idelalisib | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
62,
24,
384
]
],
[
[
62,
24,
1618
],
[
1618,
24,
384
]
],
[
[
62,
63,
305
],
[
305,
24,
384
]
],
[
[
62,
24,
1228
],
[
1228,
63,... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabozantinib"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichi... |
DB00747 | DB00782 | 1,442 | 1,123 | [
"DDInter1647",
"DDInter1535"
] | Scopolamine | Propantheline | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
1442,
24,
1123
]
],
[
[
1442,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
1442,
21,
28898
],
[
28898,
60,
1123
]
],
[
[
1442,
23,
359
],
[
35... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Scopolamine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound... | Scopolamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Scopolamine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Scopolamine may cause a minor interaction that can limit clinical effects when taken with Chloroth... |
DB00214 | DB00295 | 1,028 | 475 | [
"DDInter1836",
"DDInter1244"
] | Torasemide | Morphine | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Moderate | 1 | [
[
[
1028,
24,
475
]
],
[
[
1028,
6,
3486
],
[
3486,
45,
475
]
],
[
[
1028,
21,
28784
],
[
28784,
60,
475
]
],
[
[
1028,
25,
1425
],
[
1425... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
]
],
[
[
"Torasemide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Torasemide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Morphine (Compound)
Torasemide (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Morphine (Compound)
Torasemide may lead to a major life threatening interaction when taken with Cisapride and Cisapride ... |
DB01064 | DB06616 | 1,148 | 594 | [
"DDInter987",
"DDInter224"
] | Isoprenaline | Bosutinib | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1148,
24,
594
]
],
[
[
1148,
7,
2969
],
[
2969,
46,
594
]
],
[
[
1148,
21,
28714
],
[
28714,
60,
594
]
],
[
[
1148,
63,
1559
],
[
1559... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Isoprenaline",
"{u} (Compound) upregulates {v} (Gene)",
"CDKN1A"
],
[
"CDKN1A",
"{u} (Gene) is upregulated by {... | Isoprenaline (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Bosutinib (Compound)
Isoprenaline (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Bosutinib (Compound)
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Famot... |
DB00514 | DB12825 | 506 | 1,375 | [
"DDInter527",
"DDInter1032"
] | Dextromethorphan | Lefamulin | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
506,
24,
1375
]
],
[
[
506,
63,
530
],
[
530,
24,
1375
]
],
[
[
506,
24,
98
],
[
98,
24,
1375
]
],
[
[
506,
25,
1387
],
[
1387,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Somatrem a... |
DB01110 | DB04855 | 86 | 540 | [
"DDInter1209",
"DDInter602"
] | Miconazole | Dronedarone | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
86,
24,
540
]
],
[
[
86,
63,
228
],
[
228,
40,
540
]
],
[
[
86,
24,
33
],
[
33,
40,
540
]
],
[
[
86,
6,
8374
],
[
8374,
45,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dofetilide"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Dofetilide and Dofetilide (Compound) resembles Dronedarone (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound... |
DB00078 | DB00476 | 1,172 | 109 | [
"DDInter898",
"DDInter608"
] | Ibritumomab tiuxetan | Duloxetine | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Moderate | 1 | [
[
[
1172,
24,
109
]
],
[
[
1172,
24,
758
],
[
758,
1,
109
]
],
[
[
1172,
25,
1409
],
[
1409,
63,
109
]
],
[
[
1172,
25,
273
],
[
273,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duloxetine"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxet... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Fluoxetine and Fluoxetine (Compound) resembles Duloxetine (Compound)
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that coul... |
DB00361 | DB00851 | 134 | 611 | [
"DDInter1939",
"DDInter463"
] | Vinorelbine | Dacarbazine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
134,
24,
611
]
],
[
[
134,
5,
11555
],
[
11555,
44,
611
]
],
[
[
134,
7,
9650
],
[
9650,
57,
611
]
],
[
[
134,
23,
739
],
[
739,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Vinorelbine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Dis... | Vinorelbine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Dacarbazine (Compound)
Vinorelbine (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is downregulated by Dacarbazine (Compound)
Vinorelbine may cause a minor interaction that can limit clinical effects when ta... |
DB01222 | DB05679 | 617 | 1,683 | [
"DDInter246",
"DDInter1907"
] | Budesonide | Ustekinumab | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Moderate | 1 | [
[
[
617,
24,
1683
]
],
[
[
617,
62,
1461
],
[
1461,
23,
1683
]
],
[
[
617,
23,
1193
],
[
1193,
62,
1683
]
],
[
[
617,
24,
1129
],
[
1129,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
]
],
[
[
"Budesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Budesonide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab
Budesonide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluc... |
DB00816 | DB09082 | 1,674 | 659 | [
"DDInter1346",
"DDInter1934"
] | Orciprenaline | Vilanterol | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1674,
24,
659
]
],
[
[
1674,
23,
1220
],
[
1220,
23,
659
]
],
[
[
1674,
62,
1351
],
[
1351,
23,
659
]
],
[
[
1674,
63,
1570
],
[
1570,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Orciprenaline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dexamethasone"
],
... | Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Flunisolide and... |
DB00601 | DB01364 | 453 | 22 | [
"DDInter1073",
"DDInter650"
] | Linezolid | Ephedrine | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Major | 2 | [
[
[
453,
25,
22
]
],
[
[
453,
25,
1445
],
[
1445,
1,
22
]
],
[
[
453,
21,
28680
],
[
28680,
60,
22
]
],
[
[
453,
64,
475
],
[
475,
2... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ephedrine"
]
],
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pseudoephedrine"
],
[
"Pseudoephedrine",
... | Linezolid may lead to a major life threatening interaction when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Ephedrine (Compound)
Linezolid (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Ephedrine (Compound)
Linezolid may lead to a major life threatening interaction when... |
DB01028 | DB01276 | 1,332 | 123 | [
"DDInter1179",
"DDInter706"
] | Methoxyflurane | Exenatide | An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1332,
24,
123
]
],
[
[
1332,
24,
848
],
[
848,
24,
123
]
],
[
[
1332,
63,
361
],
[
361,
24,
123
]
],
[
[
1332,
64,
874
],
[
874,
... | [
[
[
"Methoxyflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Methoxyflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
... | Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Methoxyflurane may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neo... |
DB00264 | DB09134 | 88 | 1,552 | [
"DDInter1200",
"DDInter966"
] | Metoprolol | Ioversol | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
88,
24,
1552
]
],
[
[
88,
1,
819
],
[
819,
24,
1552
]
],
[
[
88,
40,
17
],
[
17,
24,
1552
]
],
[
[
88,
63,
1648
],
[
1648,
24,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Metoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Acebutolol"
],
[
"Acebutolol",
"{u} may cause a moderate ... | Metoprolol (Compound) resembles Acebutolol (Compound) and Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Metoprolol (Compound) resembles Sotalol (Compound) and Sotalol may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Metoprolol... |
DB00748 | DB01121 | 662 | 94 | [
"DDInter297",
"DDInter1437"
] | Carbinoxamine | Phenacemide | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. | Moderate | 1 | [
[
[
662,
24,
94
]
],
[
[
662,
24,
551
],
[
551,
1,
94
]
],
[
[
662,
63,
1614
],
[
1614,
24,
94
]
],
[
[
662,
35,
1376
],
[
1376,
24,... | [
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
]
],
[
[
"Carbinoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Phenacemide (Compound)
Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that co... |
DB01265 | DB04845 | 1,477 | 309 | [
"DDInter1757",
"DDInter1001"
] | Telbivudine | Ixabepilone | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1477,
24,
309
]
],
[
[
1477,
21,
29122
],
[
29122,
60,
309
]
],
[
[
1477,
40,
139
],
[
139,
24,
309
]
],
[
[
1477,
24,
1434
],
[
1434,... | [
[
[
"Telbivudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Telbivudine",
"{u} (Compound) causes {v} (Side Effect)",
"Mediastinal disorder"
],
[
"Mediastinal disorder",
"... | Telbivudine (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Ixabepilone (Compound)
Telbivudine (Compound) resembles Zidovudine (Compound) and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone
Telbivudine may ca... |
DB01068 | DB08900 | 1,565 | 1,162 | [
"DDInter411",
"DDInter1753"
] | Clonazepam | Teduglutide | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Teduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. Teduglutide differs from GLP-2 by one amino acid (alanine is substituted by glycine). The significance of this substitution is that te... | Moderate | 1 | [
[
[
1565,
24,
1162
]
],
[
[
1565,
1,
481
],
[
481,
24,
1162
]
],
[
[
1565,
40,
1382
],
[
1382,
24,
1162
]
],
[
[
1565,
63,
1101
],
[
1101,... | [
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teduglutide"
]
],
[
[
"Clonazepam",
"{u} (Compound) resembles {v} (Compound)",
"Quazepam"
],
[
"Quazepam",
"{u} may cause a moderate i... | Clonazepam (Compound) resembles Quazepam (Compound) and Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Teduglutide
Clonazepam (Compound) resembles Midazolam (Compound) and Midazolam may cause a moderate interaction that could exacerbate diseases when taken with Teduglutide
Clon... |
DB00850 | DB09488 | 1,630 | 103 | [
"DDInter1432",
"DDInter23"
] | Perphenazine | Acrivastine | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1630,
24,
103
]
],
[
[
1630,
63,
85
],
[
85,
24,
103
]
],
[
[
1630,
1,
146
],
[
146,
24,
103
]
],
[
[
1630,
24,
1264
],
[
1264,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Perphenazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moderate interaction that ... |
DB00264 | DB09156 | 88 | 777 | [
"DDInter1200",
"DDInter964"
] | Metoprolol | Iopromide | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
88,
24,
777
]
],
[
[
88,
40,
726
],
[
726,
24,
777
]
],
[
[
88,
24,
1013
],
[
1013,
63,
777
]
],
[
[
88,
63,
1648
],
[
1648,
24,... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Metoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Betaxolol"
],
[
"Betaxolol",
"{u} may cause a moderate i... | Metoprolol (Compound) resembles Betaxolol (Compound) and Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid and Tyropanoic acid may cause a moderate interaction tha... |
DB00087 | DB00443 | 599 | 251 | [
"DDInter41",
"DDInter195"
] | Alemtuzumab | Betamethasone | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
599,
24,
251
]
],
[
[
599,
24,
617
],
[
617,
40,
251
]
],
[
[
599,
24,
870
],
[
870,
1,
251
]
],
[
[
599,
24,
998
],
[
998,
63,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Betamethasone (Compound)
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betamet... |
DB00563 | DB01041 | 663 | 770 | [
"DDInter1174",
"DDInter1789"
] | Methotrexate | Thalidomide | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
663,
25,
770
]
],
[
[
663,
63,
1668
],
[
1668,
1,
770
]
],
[
[
663,
5,
11555
],
[
11555,
44,
770
]
],
[
[
663,
7,
7720
],
[
7720,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
],
[
"Len... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Methotrexate (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Methotrexate (Compound)... |
DB00831 | DB09082 | 1,178 | 659 | [
"DDInter1866",
"DDInter1934"
] | Trifluoperazine | Vilanterol | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1178,
24,
659
]
],
[
[
1178,
63,
870
],
[
870,
23,
659
]
],
[
[
1178,
24,
1042
],
[
1042,
23,
659
]
],
[
[
1178,
24,
1296
],
[
1296,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Tet... |
DB00539 | DB04865 | 11 | 4 | [
"DDInter1837",
"DDInter1335"
] | Toremifene | Omacetaxine mepesuccinate | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
11,
24,
4
]
],
[
[
11,
7,
14560
],
[
14560,
46,
4
]
],
[
[
11,
18,
7623
],
[
7623,
46,
4
]
],
[
[
11,
6,
9842
],
[
9842,
46,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Toremifene",
"{u} (Compound) upregulates {v} (Gene)",
"STAP2"
],
[
"STAP2",
"{u} (Gene) is upregu... | Toremifene (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Toremifene (Compound) downregulates RRP12 (Gene) and RRP12 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Toremifene (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Om... |
DB00570 | DB10429 | 147 | 200 | [
"DDInter1936",
"DDInter282"
] | Vinblastine | Candida albicans | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
147,
24,
200
]
],
[
[
147,
24,
1683
],
[
1683,
24,
200
]
],
[
[
147,
25,
976
],
[
976,
24,
200
]
],
[
[
147,
63,
168
],
[
168,
2... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Vinblastine may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitini... |
DB00794 | DB08916 | 759 | 26 | [
"DDInter1521",
"DDInter32"
] | Primidone | Afatinib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Moderate | 1 | [
[
[
759,
24,
26
]
],
[
[
759,
63,
883
],
[
883,
40,
26
]
],
[
[
759,
18,
3741
],
[
3741,
57,
26
]
],
[
[
759,
21,
28759
],
[
28759,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Afatinib"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Primidone (Compound) downregulates OXA1L (Gene) and OXA1L (Gene) is downregulated by Afatinib (Compound)
Primidone (Compound) causes Connective tissue disorder (Side... |
DB00531 | DB01177 | 450 | 77 | [
"DDInter456",
"DDInter904"
] | Cyclophosphamide | Idarubicin | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
450,
24,
77
]
],
[
[
450,
6,
6017
],
[
6017,
45,
77
]
],
[
[
450,
18,
6718
],
[
6718,
57,
77
]
],
[
[
450,
21,
28931
],
[
28931,
... | [
[
[
"Cyclophosphamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Cyclophosphamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} ... | Cyclophosphamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Cyclophosphamide (Compound) downregulates USP22 (Gene) and USP22 (Gene) is downregulated by Idarubicin (Compound)
Cyclophosphamide (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Id... |
DB00496 | DB00836 | 194 | 543 | [
"DDInter480",
"DDInter1088"
] | Darifenacin | Loperamide | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
194,
24,
543
]
],
[
[
194,
40,
704
],
[
704,
40,
543
]
],
[
[
194,
40,
11241
],
[
11241,
1,
543
]
],
[
[
194,
35,
262
],
[
262,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Darifenacin",
"{u} (Compound) resembles {v} (Compound)",
"Fentanyl"
],
[
"Fentanyl",
"{u} (Compound) resembles ... | Darifenacin (Compound) resembles Fentanyl (Compound) and Fentanyl (Compound) resembles Loperamide (Compound)
Darifenacin (Compound) resembles Isopropamide (Compound) and Isopropamide (Compound) resembles Loperamide (Compound)
Darifenacin (Compound) resembles Clidinium (Compound) and Darifenacin may cause a moderate int... |
DB00252 | DB01069 | 362 | 401 | [
"DDInter1460",
"DDInter1533"
] | Phenytoin | Promethazine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
362,
24,
401
]
],
[
[
362,
24,
1264
],
[
1264,
63,
401
]
],
[
[
362,
1,
939
],
[
939,
24,
401
]
],
[
[
362,
35,
1376
],
[
1376,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Phenytoin (Compound) resembles Benzphetamine (Compound) and Benzphetamine may cause a moderate interaction that could... |
DB11796 | DB11978 | 1,612 | 124 | [
"DDInter786",
"DDInter822"
] | Fostemsavir | Glasdegib | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1612,
24,
124
]
],
[
[
1612,
62,
112
],
[
112,
23,
124
]
],
[
[
1612,
63,
79
],
[
79,
24,
124
]
],
[
[
1612,
62,
98
],
[
98,
24,... | [
[
[
"Fostemsavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Fostemsavir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Fostemsavir may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sora... |
DB00731 | DB06077 | 1,144 | 879 | [
"DDInter1269",
"DDInter1102"
] | Nateglinide | Lumateperone | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
1144,
24,
879
]
],
[
[
1144,
24,
214
],
[
214,
63,
879
]
],
[
[
1144,
63,
1645
],
[
1645,
24,
879
]
],
[
[
1144,
24,
170
],
[
170,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Metformin and... |
DB00208 | DB06702 | 1,018 | 573 | [
"DDInter1804",
"DDInter731"
] | Ticlopidine | Fesoterodine | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
1018,
24,
573
]
],
[
[
1018,
23,
211
],
[
211,
1,
573
]
],
[
[
1018,
6,
12523
],
[
12523,
45,
573
]
],
[
[
1018,
21,
28681
],
[
28681,... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine"
],
[... | Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Ticlopidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fesoterodine (Compound)
Ticlopidine (Compound) causes Hypersensitivity (Side Effect)... |
DB00470 | DB00810 | 530 | 456 | [
"DDInter601",
"DDInter211"
] | Dronabinol | Biperiden | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Moderate | 1 | [
[
[
530,
24,
456
]
],
[
[
530,
63,
1105
],
[
1105,
40,
456
]
],
[
[
530,
6,
4973
],
[
4973,
45,
456
]
],
[
[
530,
24,
104
],
[
104,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Biperiden"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Biperiden (Compound)
Dronabinol (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Biperiden (Compound)
Dronabinol may cause a moderate interaction that could exace... |
DB05351 | DB09263 | 101 | 1,436 | [
"DDInter519",
"DDInter1399"
] | Dexlansoprazole | Patiromer | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation... | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
101,
24,
1436
]
],
[
[
101,
24,
428
],
[
428,
63,
1436
]
],
[
[
101,
63,
1152
],
[
1152,
24,
1436
]
],
[
[
101,
24,
428
],
[
428,
... | [
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
... | Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00816 | DB00819 | 1,674 | 471 | [
"DDInter1346",
"DDInter15"
] | Orciprenaline | Acetazolamide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its ... | Moderate | 1 | [
[
[
1674,
24,
471
]
],
[
[
1674,
63,
997
],
[
997,
40,
471
]
],
[
[
1674,
21,
29232
],
[
29232,
60,
471
]
],
[
[
1674,
24,
1264
],
[
1264,... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetazolamide"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methazolamide"
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methazolamide and Methazolamide (Compound) resembles Acetazolamide (Compound)
Orciprenaline (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Acetazolamide (Compound)
Orciprenaline may cause a ... |
DB00026 | DB09322 | 1,184 | 1,114 | [
"DDInter94",
"DDInter1966"
] | Anakinra | Zinc sulfate | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Minor | 0 | [
[
[
1184,
23,
1114
]
],
[
[
1184,
24,
66
],
[
66,
23,
1114
]
],
[
[
1184,
24,
1093
],
[
1093,
62,
1114
]
],
[
[
1184,
64,
1057
],
[
1057,
... | [
[
[
"Anakinra",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Efalizumab"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixekizumab... |
DB00374 | DB14840 | 1,061 | 861 | [
"DDInter1852",
"DDInter1601"
] | Treprostinil | Ripretinib | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1061,
24,
861
]
],
[
[
1061,
24,
392
],
[
392,
24,
861
]
],
[
[
1061,
25,
1213
],
[
1213,
24,
861
]
],
[
[
1061,
24,
1604
],
[
1604,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Treprostinil may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause ... |
DB00681 | DB06288 | 1,287 | 607 | [
"DDInter85",
"DDInter77"
] | Amphotericin B | Amisulpride | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Moderate | 1 | [
[
[
1287,
24,
607
]
],
[
[
1287,
21,
29232
],
[
29232,
60,
607
]
],
[
[
1287,
24,
870
],
[
870,
24,
607
]
],
[
[
1287,
63,
589
],
[
589,
... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amisulpride"
]
],
[
[
"Amphotericin B",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect... | Amphotericin B (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Amisulpride (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when... |
DB00631 | DB08896 | 372 | 292 | [
"DDInter405",
"DDInter1576"
] | Clofarabine | Regorafenib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
372,
24,
292
]
],
[
[
372,
63,
79
],
[
79,
1,
292
]
],
[
[
372,
7,
6120
],
[
6120,
45,
292
]
],
[
[
372,
6,
17404
],
[
17404,
45... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Clofarabine (Compound) upregulates EPHA2 (Gene) and EPHA2 (Gene) is bound by Regorafenib (Compound)
Clofarabine (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) i... |
DB11581 | DB14575 | 1,456 | 733 | [
"DDInter1926",
"DDInter674"
] | Venetoclax | Eslicarbazepine | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Major | 2 | [
[
[
1456,
25,
733
]
],
[
[
1456,
63,
1101
],
[
1101,
23,
733
]
],
[
[
1456,
64,
1491
],
[
1491,
24,
733
]
],
[
[
1456,
62,
1135
],
[
1135,... | [
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexar... | Venetoclax may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Venetoclax may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may c... |
DB01177 | DB01259 | 77 | 392 | [
"DDInter904",
"DDInter1024"
] | Idarubicin | Lapatinib | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
77,
24,
392
]
],
[
[
77,
5,
11579
],
[
11579,
44,
392
]
],
[
[
77,
7,
3727
],
[
3727,
46,
392
]
],
[
[
77,
18,
18008
],
[
18008,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Idarubicin",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treat... | Idarubicin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Lapatinib (Compound)
Idarubicin (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
Idarubicin (Compound) downregulates BAMBI (Gene) and BAMBI (Gene) is upregulated by Lapatinib (Compound)
... |
DB01041 | DB01367 | 770 | 1,163 | [
"DDInter1789",
"DDInter1572"
] | Thalidomide | Rasagiline | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
770,
24,
1163
]
],
[
[
770,
6,
7950
],
[
7950,
45,
1163
]
],
[
[
770,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
770,
63,
100
],
[
100,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Thalidomide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Thalidomide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Rasagiline (Compound)
Thalidomide (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine an... |
DB00877 | DB12141 | 629 | 971 | [
"DDInter1678",
"DDInter817"
] | Sirolimus | Gilteritinib | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
629,
24,
971
]
],
[
[
629,
64,
485
],
[
485,
24,
971
]
],
[
[
629,
24,
1097
],
[
1097,
24,
971
]
],
[
[
629,
63,
1335
],
[
1335,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentamidine"
],
[
"Pentamidi... | Sirolimus may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan and Lasmiditan may caus... |
DB00073 | DB10795 | 1,394 | 221 | [
"DDInter1608",
"DDInter1486"
] | Rituximab | Poliovirus type 1 antigen (formaldehyde inactivated) | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1394,
24,
221
]
],
[
[
1394,
64,
581
],
[
581,
24,
221
]
],
[
[
1394,
24,
599
],
[
599,
24,
221
]
],
[
[
1394,
25,
1510
],
[
1510,
... | [
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"In... | Rituximab may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Rituximab may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00570 | DB12674 | 147 | 975 | [
"DDInter1936",
"DDInter1105"
] | Vinblastine | Lurbinectedin | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
147,
24,
975
]
],
[
[
147,
24,
1488
],
[
1488,
24,
975
]
],
[
[
147,
24,
159
],
[
159,
63,
975
]
],
[
[
147,
23,
60
],
[
60,
24,... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib ... |
DB00295 | DB09272 | 475 | 412 | [
"DDInter1244",
"DDInter632"
] | Morphine | Eluxadoline | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
475,
24,
412
]
],
[
[
475,
24,
1594
],
[
1594,
24,
412
]
],
[
[
475,
25,
252
],
[
252,
24,
412
]
],
[
[
475,
24,
1536
],
[
1536,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Morphine may lead to a major life threatening interaction when taken with Hydroxyzine and Hydroxyzine may cause a... |
DB00747 | DB00960 | 1,442 | 887 | [
"DDInter1647",
"DDInter1471"
] | Scopolamine | Pindolol | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Moderate | 1 | [
[
[
1442,
24,
887
]
],
[
[
1442,
24,
819
],
[
819,
40,
887
]
],
[
[
1442,
63,
88
],
[
88,
40,
887
]
],
[
[
1442,
63,
1121
],
[
1121,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Pindolol (Compound)
Sc... |
DB01170 | DB06292 | 1,150 | 549 | [
"DDInter846",
"DDInter474"
] | Guanethidine | Dapagliflozin | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
1150,
24,
549
]
],
[
[
1150,
24,
1344
],
[
1344,
40,
549
]
],
[
[
1150,
6,
8374
],
[
8374,
45,
549
]
],
[
[
1150,
63,
1636
],
[
1636,
... | [
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Guanethidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]... | Guanethidine may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Guanethidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Guanethidine may cause a moderate interaction that... |
DB01021 | DB11057 | 674 | 720 | [
"DDInter1861",
"DDInter1223"
] | Trichlormethiazide | Mineral oil | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
674,
24,
720
]
],
[
[
674,
63,
175
],
[
175,
24,
720
]
],
[
[
674,
1,
323
],
[
323,
24,
720
]
],
[
[
674,
40,
178
],
[
178,
24,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinol... | Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Trichlormethiazide (Compound) resembles Bendroflumethiazide (Compound) and Bendroflumethiazide ma... |
DB00001 | DB00215 | 1,578 | 1,230 | [
"DDInter1037",
"DDInter388"
] | Lepirudin | Citalopram | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Moderate | 1 | [
[
[
1578,
24,
1230
]
],
[
[
1578,
24,
318
],
[
318,
40,
1230
]
],
[
[
1578,
25,
500
],
[
500,
63,
1230
]
],
[
[
1578,
24,
885
],
[
885,
... | [
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
],
[
... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram (Compound) resembles Citalopram (Compound)
Lepirudin may lead to a major life threatening interaction when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate d... |
DB11093 | DB11799 | 636 | 627 | [
"DDInter273",
"DDInter205"
] | Calcium citrate | Bictegravir | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Major | 2 | [
[
[
636,
25,
627
]
],
[
[
636,
63,
72
],
[
72,
24,
627
]
],
[
[
636,
64,
115
],
[
115,
25,
627
]
],
[
[
636,
63,
72
],
[
72,
24,
... | [
[
[
"Calcium citrate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bictegravir"
]
],
[
[
"Calcium citrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
],
[
... | Calcium citrate may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Calcium citrate may lead to a major life threatening interaction when taken with Aluminum hydroxide and ... |
DB01174 | DB01246 | 697 | 820 | [
"DDInter1442",
"DDInter45"
] | Phenobarbital | Alimemazine | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
697,
24,
820
]
],
[
[
697,
63,
104
],
[
104,
40,
820
]
],
[
[
697,
63,
401
],
[
401,
24,
820
]
],
[
[
697,
24,
649
],
[
649,
1,
... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],... | Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interac... |
DB00176 | DB05812 | 529 | 1,374 | [
"DDInter770",
"DDInter8"
] | Fluvoxamine | Abiraterone | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
529,
24,
1374
]
],
[
[
529,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
529,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
529,
23,
466
],
[
466,... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Fluvoxamine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Fluvoxamine (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Fluvoxamine may cause a minor interaction that can limit clinical effects when taken with Darolutami... |
DB05812 | DB12301 | 1,374 | 907 | [
"DDInter8",
"DDInter585"
] | Abiraterone | Doravirine | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
1374,
23,
907
]
],
[
[
1374,
24,
1478
],
[
1478,
23,
907
]
],
[
[
1374,
24,
159
],
[
159,
62,
907
]
],
[
[
1374,
63,
1213
],
[
1213,
... | [
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB01403 | DB11057 | 9 | 720 | [
"DDInter1175",
"DDInter1223"
] | Methotrimeprazine | Mineral oil | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
9,
24,
720
]
],
[
[
9,
24,
927
],
[
927,
63,
720
]
],
[
[
9,
63,
1151
],
[
1151,
24,
720
]
],
[
[
9,
25,
1069
],
[
1069,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"... | Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Suni... |
DB00405 | DB00647 | 128 | 675 | [
"DDInter517",
"DDInter528"
] | Dexbrompheniramine | Dextropropoxyphene | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Major | 2 | [
[
[
128,
25,
675
]
],
[
[
128,
63,
494
],
[
494,
1,
675
]
],
[
[
128,
24,
1511
],
[
1511,
63,
675
]
],
[
[
128,
24,
649
],
[
649,
1,... | [
[
[
"Dexbrompheniramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Dextropropoxyphene (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a m... |
DB00035 | DB00712 | 1,314 | 1,274 | [
"DDInter507",
"DDInter763"
] | Desmopressin | Flurbiprofen | Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release... | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Moderate | 1 | [
[
[
1314,
24,
1274
]
],
[
[
1314,
24,
935
],
[
935,
63,
1274
]
],
[
[
1314,
6,
10522
],
[
10522,
45,
1274
]
],
[
[
1314,
21,
28769
],
[
28... | [
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
]
],
[
[
"Desmopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
... | Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen
Desmopressin (Compound) binds PTGS1 (Gene) and PTGS1 (Gene) is bound by Flurbiprofen (Compound)
Desmopressin... |
DB00023 | DB00175 | 305 | 681 | [
"DDInter127",
"DDInter1509"
] | Asparaginase Escherichia coli | Pravastatin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Moderate | 1 | [
[
[
305,
24,
681
]
],
[
[
305,
24,
1463
],
[
1463,
40,
681
]
],
[
[
305,
24,
126
],
[
126,
62,
681
]
],
[
[
305,
24,
322
],
[
322,
6... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pravastatin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin (Compound) resembles Pravastatin (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may caus... |
DB00108 | DB00488 | 1,066 | 196 | [
"DDInter1268",
"DDInter57"
] | Natalizumab | Altretamine | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Major | 2 | [
[
[
1066,
25,
196
]
],
[
[
1066,
25,
139
],
[
139,
63,
196
]
],
[
[
1066,
64,
1184
],
[
1184,
24,
196
]
],
[
[
1066,
24,
496
],
[
496,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Altretamine"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
[
"Zidovudine",
"{u... | Natalizumab may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Altretamine
Natalizumab may lead to a major life threatening interaction when taken with Anakinra and Anakinra may cause a moderate inter... |
DB01042 | DB10316 | 1,307 | 334 | [
"DDInter1144",
"DDInter1248"
] | Melphalan | Mumps virus strain B level jeryl lynn live antigen | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1307,
25,
334
]
],
[
[
1307,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1307,
63,
328
],
[
328,
25,
334
]
],
[
[
1307,
25,
908
],
[
908,
... | [
[
[
"Melphalan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Melphalan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
],
... | Melphalan may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurin... |
DB08875 | DB09083 | 1,618 | 880 | [
"DDInter262",
"DDInter996"
] | Cabozantinib | Ivabradine | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
1618,
25,
880
]
],
[
[
1618,
63,
480
],
[
480,
24,
880
]
],
[
[
1618,
24,
159
],
[
159,
63,
880
]
],
[
[
1618,
24,
1040
],
[
1040,
... | [
[
[
"Cabozantinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Cabozantinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formot... | Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and... |
DB00218 | DB09038 | 1,176 | 1,450 | [
"DDInter1247",
"DDInter636"
] | Moxifloxacin | Empagliflozin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1176,
24,
1450
]
],
[
[
1176,
25,
485
],
[
485,
24,
1450
]
],
[
[
1176,
24,
659
],
[
659,
63,
1450
]
],
[
[
1176,
1,
872
],
[
872,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentamidine"
],
[
"Pe... | Moxifloxacin may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol m... |
DB08879 | DB08908 | 632 | 713 | [
"DDInter173",
"DDInter564"
] | Belimumab | Dimethyl fumarate | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
632,
24,
713
]
],
[
[
632,
63,
4
],
[
4,
24,
713
]
],
[
[
632,
24,
270
],
[
270,
63,
713
]
],
[
[
632,
25,
976
],
[
976,
25,
... | [
[
[
"Belimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Belimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccin... | Belimumab may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Belimumab may cause a moderate interaction that could exacerbate diseases wh... |
DB00280 | DB00501 | 494 | 752 | [
"DDInter575",
"DDInter380"
] | Disopyramide | Cimetidine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
494,
23,
752
]
],
[
[
494,
6,
8803
],
[
8803,
45,
752
]
],
[
[
494,
21,
29134
],
[
29134,
60,
752
]
],
[
[
494,
23,
112
],
[
112,
... | [
[
[
"Disopyramide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"SLC22A2"
],
[
"SLC22A2",
"{u} (Gene) is bound by {v} (Compoun... | Disopyramide (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Cimetidine (Compound)
Disopyramide (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Disopyramide may cause a minor interaction that can limit clinical effects when taken with Metronidazo... |
DB00363 | DB00372 | 695 | 999 | [
"DDInter419",
"DDInter1793"
] | Clozapine | Thiethylperazine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
695,
24,
999
]
],
[
[
695,
24,
286
],
[
286,
62,
999
]
],
[
[
695,
24,
1614
],
[
1614,
63,
999
]
],
[
[
695,
63,
352
],
[
352,
2... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with N... |
DB00762 | DB10429 | 613 | 200 | [
"DDInter973",
"DDInter282"
] | Irinotecan | Candida albicans | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
613,
24,
200
]
],
[
[
613,
24,
1683
],
[
1683,
24,
200
]
],
[
[
613,
25,
976
],
[
976,
24,
200
]
],
[
[
613,
63,
1101
],
[
1101,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Irinotecan may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ... |
DB00708 | DB01156 | 1,454 | 593 | [
"DDInter1718",
"DDInter252"
] | Sufentanil | Bupropion | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
1454,
25,
593
]
],
[
[
1454,
6,
8374
],
[
8374,
45,
593
]
],
[
[
1454,
21,
29034
],
[
29034,
60,
593
]
],
[
[
1454,
24,
256
],
[
256,
... | [
[
[
"Sufentanil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Sufentanil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Bupropio... | Sufentanil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bupropion (Compound)
Sufentanil (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Bupropion (Compound)
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken ... |
DB01097 | DB01229 | 1,377 | 973 | [
"DDInter1033",
"DDInter1378"
] | Leflunomide | Paclitaxel (protein-bound) | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Major | 2 | [
[
[
1377,
25,
973
]
],
[
[
1377,
25,
310
],
[
310,
63,
973
]
],
[
[
1377,
6,
6017
],
[
6017,
45,
973
]
],
[
[
1377,
7,
9489
],
[
9489,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel",
"{... | Leflunomide may lead to a major life threatening interaction when taken with Paclitaxel
Leflunomide may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Leflunomide (Compound) binds CYP2C9 ... |
DB00912 | DB11986 | 473 | 484 | [
"DDInter1581",
"DDInter648"
] | Repaglinide | Entrectinib | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
473,
24,
484
]
],
[
[
473,
24,
1247
],
[
1247,
23,
484
]
],
[
[
473,
24,
466
],
[
466,
62,
484
]
],
[
[
473,
63,
1197
],
[
1197,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Daroluta... |
DB00373 | DB08868 | 461 | 1,011 | [
"DDInter1809",
"DDInter737"
] | Timolol | Fingolimod | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
461,
25,
1011
]
],
[
[
461,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
461,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
461,
23,
578
],
[
578,... | [
[
[
"Timolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Timolol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Fingolimod"
... | Timolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Timolol (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Timolol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor and Ticag... |
DB00372 | DB00418 | 999 | 536 | [
"DDInter1793",
"DDInter1650"
] | Thiethylperazine | Secobarbital | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Moderate | 1 | [
[
[
999,
24,
536
]
],
[
[
999,
63,
1023
],
[
1023,
1,
536
]
],
[
[
999,
24,
697
],
[
697,
1,
536
]
],
[
[
999,
24,
1233
],
[
1233,
6... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Secobarbital (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resemb... |
DB00835 | DB01221 | 100 | 1,190 | [
"DDInter245",
"DDInter1007"
] | Brompheniramine | Ketamine | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic... | Moderate | 1 | [
[
[
100,
24,
1190
]
],
[
[
100,
6,
8374
],
[
8374,
45,
1190
]
],
[
[
100,
24,
649
],
[
649,
63,
1190
]
],
[
[
100,
35,
849
],
[
849,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketamine"
]
],
[
[
"Brompheniramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Brompheniramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ketamine (Compound)
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Ketamine
Brompheniram... |
DB01244 | DB06788 | 762 | 1,616 | [
"DDInter192",
"DDInter864"
] | Bepridil | Histrelin | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
762,
25,
1616
]
],
[
[
762,
62,
112
],
[
112,
23,
1616
]
],
[
[
762,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
762,
64,
77
],
[
77,
... | [
[
[
"Bepridil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Bepridil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazole"... | Bepridil may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Bepridil may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may cause a m... |
DB01050 | DB14761 | 848 | 242 | [
"DDInter900",
"DDInter1578"
] | Ibuprofen | Remdesivir | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
848,
24,
242
]
],
[
[
848,
63,
1512
],
[
1512,
24,
242
]
],
[
[
848,
25,
1377
],
[
1377,
24,
242
]
],
[
[
848,
24,
129
],
[
129,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
... | Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Ibuprofen may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause ... |
DB00075 | DB06168 | 541 | 1,531 | [
"DDInter1250",
"DDInter281"
] | Muromonab | Canakinumab | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
541,
24,
1531
]
],
[
[
541,
23,
1193
],
[
1193,
62,
1531
]
],
[
[
541,
23,
1461
],
[
1461,
23,
1531
]
],
[
[
541,
24,
1270
],
[
1270,
... | [
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Muromonab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Muromonab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Muromonab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitami... |
DB00376 | DB00804 | 1,105 | 1,507 | [
"DDInter1870",
"DDInter543"
] | Trihexyphenidyl | Dicyclomine | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
1105,
24,
1507
]
],
[
[
1105,
6,
2720
],
[
2720,
45,
1507
]
],
[
[
1105,
21,
28817
],
[
28817,
60,
1507
]
],
[
[
1105,
24,
1021
],
[
1... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Trihexyphenidyl",
"{u} (Compound) binds {v} (Gene)",
"CHRM3"
],
[
"CHRM3",
"{u} (Gene) is bound by {v} (Co... | Trihexyphenidyl (Compound) binds CHRM3 (Gene) and CHRM3 (Gene) is bound by Dicyclomine (Compound)
Trihexyphenidyl (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Dicyclomine (Compound)
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken... |
DB01186 | DB08824 | 107 | 591 | [
"DDInter1430",
"DDInter959"
] | Pergolide | Ioflupane I-123 | Pergolide is a long-acting dopamine agonist approved in 1982 for the treatment of Parkinson’s Disease. It is an ergot derivative that acts on the dopamine D2 and D3, alpha2- and alpha1-adrenergic, and 5-hydroxytryptamine (5-HT) receptors. It was indicated as adjunct therapy with levodopa/carbidopa in the symptomatic tr... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
107,
24,
591
]
],
[
[
107,
21,
29305
],
[
29305,
60,
591
]
],
[
[
107,
63,
401
],
[
401,
24,
591
]
],
[
[
107,
24,
1311
],
[
1311,
... | [
[
[
"Pergolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Pergolide",
"{u} (Compound) causes {v} (Side Effect)",
"Dysgeusia"
],
[
"Dysgeusia",
"{u} (Side Effect) is c... | Pergolide (Compound) causes Dysgeusia (Side Effect) and Dysgeusia (Side Effect) is caused by Ioflupane I-123 (Compound)
Pergolide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00358 | DB01069 | 1,010 | 401 | [
"DDInter1140",
"DDInter1533"
] | Mefloquine | Promethazine | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1010,
24,
401
]
],
[
[
1010,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1010,
24,
1236
],
[
1236,
24,
401
]
],
[
[
1010,
6,
12523
],
[
12523... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbama... |
DB00069 | DB00549 | 367 | 522 | [
"DDInter946",
"DDInter1955"
] | Interferon alfacon-1 | Zafirlukast | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Moderate | 1 | [
[
[
367,
24,
522
]
],
[
[
367,
24,
168
],
[
168,
24,
522
]
],
[
[
367,
24,
1488
],
[
1488,
63,
522
]
],
[
[
367,
63,
491
],
[
491,
2... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortez... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with ... |
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