drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00514 | DB01320 | 506 | 651 | [
"DDInter527",
"DDInter783"
] | Dextromethorphan | Fosphenytoin | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
506,
24,
651
]
],
[
[
506,
63,
362
],
[
362,
1,
651
]
],
[
[
506,
6,
6017
],
[
6017,
45,
651
]
],
[
[
506,
21,
28691
],
[
28691,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Dextromethorphan (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Fosphenytoin (Compound)
Dextromethorphan (Compound) causes Somnolence (Side ... |
DB00675 | DB01087 | 888 | 1,520 | [
"DDInter1744",
"DDInter1520"
] | Tamoxifen | Primaquine | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
888,
24,
1520
]
],
[
[
888,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
888,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
888,
18,
8800
],
[
8800,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"Hydr... | Tamoxifen may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Tamoxifen (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Tamoxifen (Compound) downregulates... |
DB00277 | DB00280 | 1,031 | 494 | [
"DDInter1791",
"DDInter575"
] | Theophylline | Disopyramide | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Moderate | 1 | [
[
[
1031,
24,
494
]
],
[
[
1031,
6,
8374
],
[
8374,
45,
494
]
],
[
[
1031,
21,
28658
],
[
28658,
60,
494
]
],
[
[
1031,
24,
752
],
[
752,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
]
],
[
[
"Theophylline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Theophylline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Disopyramide (Compound)
Theophylline (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Disopyramide (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine ... |
DB05239 | DB11003 | 866 | 748 | [
"DDInter425",
"DDInter100"
] | Cobimetinib | Anthrax vaccine | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
866,
24,
748
]
],
[
[
866,
63,
322
],
[
322,
24,
748
]
],
[
[
866,
25,
676
],
[
676,
63,
748
]
],
[
[
866,
24,
1683
],
[
1683,
2... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Cobimetinib may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib... |
DB00361 | DB11828 | 134 | 1,406 | [
"DDInter1939",
"DDInter1281"
] | Vinorelbine | Neratinib | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
134,
24,
1406
]
],
[
[
134,
25,
1510
],
[
1510,
24,
1406
]
],
[
[
134,
24,
985
],
[
985,
24,
1406
]
],
[
[
134,
24,
1619
],
[
1619,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
],
[
"Terifl... | Vinorelbine may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib and Osimertinib m... |
DB00370 | DB12130 | 1,251 | 1,017 | [
"DDInter1230",
"DDInter1094"
] | Mirtazapine | Lorlatinib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1251,
24,
1017
]
],
[
[
1251,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
1251,
24,
126
],
[
126,
24,
1017
]
],
[
[
1251,
25,
11
],
[
11,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin... |
DB00975 | DB06822 | 1,317 | 802 | [
"DDInter573",
"DDInter1812"
] | Dipyridamole | Tinzaparin | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
1317,
25,
802
]
],
[
[
1317,
23,
944
],
[
944,
62,
802
]
],
[
[
1317,
24,
222
],
[
222,
24,
802
]
],
[
[
1317,
63,
383
],
[
383,
... | [
[
[
"Dipyridamole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Dipyridamole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile... | Dipyridamole may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutra... |
DB00851 | DB00970 | 611 | 0 | [
"DDInter463",
"DDInter466"
] | Dacarbazine | Dactinomycin | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Moderate | 1 | [
[
[
611,
24,
0
]
],
[
[
611,
5,
11635
],
[
11635,
44,
0
]
],
[
[
611,
7,
7669
],
[
7669,
57,
0
]
],
[
[
611,
23,
246
],
[
246,
62,
... | [
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dactinomycin"
]
],
[
[
"Dacarbazine",
"{u} (Compound) treats {v} (Disease)",
"muscle cancer"
],
[
"muscle cancer",
"{u} (Disease) is ... | Dacarbazine (Compound) treats muscle cancer (Disease) and muscle cancer (Disease) is treated by Dactinomycin (Compound)
Dacarbazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is downregulated by Dactinomycin (Compound)
Dacarbazine may cause a minor interaction that can limit clinical effects when taken with G... |
DB00783 | DB01261 | 1,438 | 170 | [
"DDInter679",
"DDInter1679"
] | Estradiol | Sitagliptin | Estradiol is a naturally occurring hormone circulating endogenously in females. It is commercially available in several hormone therapy products for managing conditions associated with reduced estrogen, such as vulvovaginal atrophy and hot flashes. Some available forms of estradiol include oral tablets, injections, vag... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1438,
24,
170
]
],
[
[
1438,
6,
3486
],
[
3486,
45,
170
]
],
[
[
1438,
18,
1948
],
[
1948,
57,
170
]
],
[
[
1438,
21,
28850
],
[
28850... | [
[
[
"Estradiol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Estradiol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
... | Estradiol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Sitagliptin (Compound)
Estradiol (Compound) downregulates IFNAR1 (Gene) and IFNAR1 (Gene) is downregulated by Sitagliptin (Compound)
Estradiol (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
... |
DB00238 | DB08899 | 188 | 129 | [
"DDInter1285",
"DDInter649"
] | Nevirapine | Enzalutamide | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
188,
24,
129
]
],
[
[
188,
6,
8374
],
[
8374,
45,
129
]
],
[
[
188,
21,
28703
],
[
28703,
60,
129
]
],
[
[
188,
23,
608
],
[
608,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Nevirapine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Nevirapine may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidoc... |
DB00852 | DB00865 | 1,445 | 939 | [
"DDInter1545",
"DDInter187"
] | Pseudoephedrine | Benzphetamine | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Moderate | 1 | [
[
[
1445,
24,
939
]
],
[
[
1445,
35,
1529
],
[
1529,
1,
939
]
],
[
[
1445,
63,
80
],
[
80,
40,
939
]
],
[
[
1445,
36,
1161
],
[
1161,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases... | Pseudoephedrine (Compound) resembles Metamfetamine (Compound) and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Benzphetamine (Compound)
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases ... |
DB01249 | DB14509 | 258 | 1,399 | [
"DDInter958",
"DDInter1081"
] | Iodixanol | Lithium carbonate | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
258,
25,
1399
]
],
[
[
258,
64,
589
],
[
589,
23,
1399
]
],
[
[
258,
24,
1574
],
[
1574,
23,
1399
]
],
[
[
258,
64,
387
],
[
387,
... | [
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Iodixanol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cisplatin"
],
[
"Cisplatin",
"{u... | Iodixanol may lead to a major life threatening interaction when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Iodixanol may cause a moderate interaction that could exacerbate diseases when taken with Urea and Urea may cause a minor int... |
DB00881 | DB01234 | 954 | 1,220 | [
"DDInter1554",
"DDInter513"
] | Quinapril | Dexamethasone | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
954,
24,
1220
]
],
[
[
954,
63,
870
],
[
870,
1,
1220
]
],
[
[
954,
63,
175
],
[
175,
40,
1220
]
],
[
[
954,
24,
617
],
[
617,
4... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexam... |
DB08870 | DB12001 | 850 | 564 | [
"DDInter228",
"DDInter7"
] | Brentuximab vedotin | Abemaciclib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
850,
24,
564
]
],
[
[
850,
24,
868
],
[
868,
24,
564
]
],
[
[
850,
63,
58
],
[
58,
24,
564
]
],
[
[
850,
24,
1017
],
[
1017,
63,... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafe... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00762 | DB01059 | 613 | 956 | [
"DDInter973",
"DDInter1313"
] | Irinotecan | Norfloxacin | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Minor | 0 | [
[
[
613,
23,
956
]
],
[
[
613,
23,
872
],
[
872,
40,
956
]
],
[
[
613,
62,
1176
],
[
1176,
1,
956
]
],
[
[
613,
23,
1539
],
[
1539,
... | [
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Norfloxacin"
]
],
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
[
... | Irinotecan may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Norfloxacin (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Norfloxacin (Comp... |
DB00704 | DB00987 | 267 | 1,224 | [
"DDInter1263",
"DDInter460"
] | Naltrexone | Cytarabine | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
267,
24,
1224
]
],
[
[
267,
7,
2900
],
[
2900,
46,
1224
]
],
[
[
267,
18,
2183
],
[
2183,
57,
1224
]
],
[
[
267,
63,
1176
],
[
1176,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Naltrexone",
"{u} (Compound) upregulates {v} (Gene)",
"NFKBIA"
],
[
"NFKBIA",
"{u} (Gene) is upregulated by {v} ... | Naltrexone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Cytarabine (Compound)
Naltrexone (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Cytarabine (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin an... |
DB00902 | DB01037 | 104 | 1,161 | [
"DDInter1168",
"DDInter1653"
] | Methdilazine | Selegiline | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual... | Moderate | 1 | [
[
[
104,
24,
1161
]
],
[
[
104,
63,
551
],
[
551,
1,
1161
]
],
[
[
104,
24,
1529
],
[
1529,
1,
1161
]
],
[
[
104,
63,
80
],
[
80,
40... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selegiline"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Selegiline (Compound)
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Selegiline (... |
DB00350 | DB01284 | 1,214 | 1,042 | [
"DDInter1226",
"DDInter1782"
] | Minoxidil | Tetracosactide | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1214,
24,
1042
]
],
[
[
1214,
24,
1664
],
[
1664,
24,
1042
]
],
[
[
1214,
24,
607
],
[
607,
63,
1042
]
],
[
[
1214,
64,
1000
],
[
1000... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Amisulpride and A... |
DB00209 | DB01403 | 352 | 9 | [
"DDInter1886",
"DDInter1175"
] | Trospium | Methotrimeprazine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
352,
24,
9
]
],
[
[
352,
24,
1178
],
[
1178,
40,
9
]
],
[
[
352,
24,
1164
],
[
1164,
1,
9
]
],
[
[
352,
24,
401
],
[
401,
24,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Metho... |
DB00196 | DB00317 | 600 | 883 | [
"DDInter743",
"DDInter810"
] | Fluconazole | Gefitinib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Moderate | 1 | [
[
[
600,
24,
883
]
],
[
[
600,
25,
594
],
[
594,
40,
883
]
],
[
[
600,
25,
1069
],
[
1069,
1,
883
]
],
[
[
600,
6,
7524
],
[
7524,
4... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
],
[
"Bosutinib"... | Fluconazole may lead to a major life threatening interaction when taken with Bosutinib and Bosutinib (Compound) resembles Gefitinib (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib (Compound) resembles Gefitinib (Compound)
Fluconazole (Compound) binds CYP... |
DB00792 | DB01589 | 832 | 481 | [
"DDInter1878",
"DDInter1552"
] | Tripelennamine | Quazepam | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
832,
24,
481
]
],
[
[
832,
63,
1216
],
[
1216,
1,
481
]
],
[
[
832,
24,
1418
],
[
1418,
1,
481
]
],
[
[
832,
63,
905
],
[
905,
4... | [
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Tripelennamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
... | Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Quazepam (Compound... |
DB01017 | DB05528 | 1,669 | 1,070 | [
"DDInter1224",
"DDInter1228"
] | Minocycline | Mipomersen | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
1669,
25,
1070
]
],
[
[
1669,
64,
1517
],
[
1517,
25,
1070
]
],
[
[
1669,
24,
384
],
[
384,
64,
1070
]
],
[
[
1669,
40,
1620
],
[
1620... | [
[
[
"Minocycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Minocycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isotretinoin"
],
[
"Isotretinoin",
... | Minocycline may lead to a major life threatening interaction when taken with Isotretinoin and Isotretinoin may lead to a major life threatening interaction when taken with Mipomersen
Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may lead to a major... |
DB04865 | DB14409 | 4 | 1,129 | [
"DDInter1335",
"DDInter867"
] | Omacetaxine mepesuccinate | Human adenovirus e serotype 4 strain cl-68578 antigen | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
4,
24,
1129
]
],
[
[
4,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
4,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
4,
63,
134
],
[
134,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interactio... | Omacetaxine mepesuccinate may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Omacetaxine mepesuccinate may cause a moderate interaction that could... |
DB01118 | DB06772 | 33 | 310 | [
"DDInter76",
"DDInter259"
] | Amiodarone | Cabazitaxel | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Moderate | 1 | [
[
[
33,
24,
310
]
],
[
[
33,
24,
973
],
[
973,
24,
310
]
],
[
[
33,
6,
7524
],
[
7524,
45,
310
]
],
[
[
33,
21,
28894
],
[
28894,
60... | [
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel
Amiodarone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Cabazitaxel (Compound)
Amiodarone (Comp... |
DB01070 | DB11110 | 1,098 | 603 | [
"DDInter558",
"DDInter1115"
] | Dihydrotachysterol | Magnesium citrate | A vitamin D that can be regarded as a reduction product of vitamin D2. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1098,
24,
603
]
],
[
[
1098,
25,
1196
],
[
1196,
24,
603
]
],
[
[
1098,
63,
544
],
[
544,
24,
603
]
],
[
[
1098,
75,
1331
],
[
1331,
... | [
[
[
"Dihydrotachysterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Dihydrotachysterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxercalciferol"
... | Dihydrotachysterol may lead to a major life threatening interaction when taken with Doxercalciferol and Doxercalciferol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Dihydrotachysterol may cause a moderate interaction that could exacerbate diseases when taken with Mag... |
DB00802 | DB14568 | 1,322 | 982 | [
"DDInter43",
"DDInter1000"
] | Alfentanil | Ivosidenib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
1322,
24,
982
]
],
[
[
1322,
63,
1101
],
[
1101,
23,
982
]
],
[
[
1322,
62,
608
],
[
608,
23,
982
]
],
[
[
1322,
24,
976
],
[
976,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Alfentanil may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine m... |
DB01583 | DB13142 | 624 | 841 | [
"DDInter1075",
"DDInter274"
] | Liotrix | Calcium glubionate anhydrous | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
624,
24,
841
]
],
[
[
624,
40,
1152
],
[
1152,
24,
841
]
],
[
[
624,
1,
542
],
[
542,
24,
841
]
],
[
[
624,
63,
1231
],
[
1231,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Liotrix",
"{u} (Compound) resembles {v} (Compound)",
"Liothyronine"
],
[
"Liothyronine",
"{u} may... | Liotrix (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Calcium glubionate anhydrous
Liotrix (Compound) resembles Levothyroxine (Compound) and Levothyroxine may cause a moderate interaction that could exacerbate diseases when ... |
DB01236 | DB09330 | 679 | 985 | [
"DDInter1664",
"DDInter1352"
] | Sevoflurane | Osimertinib | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
679,
25,
985
]
],
[
[
679,
62,
112
],
[
112,
23,
985
]
],
[
[
679,
63,
480
],
[
480,
24,
985
]
],
[
[
679,
24,
657
],
[
657,
63,... | [
[
[
"Sevoflurane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Sevoflurane",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Sevoflurane may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and F... |
DB00432 | DB11003 | 1,083 | 748 | [
"DDInter1868",
"DDInter100"
] | Trifluridine | Anthrax vaccine | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
1083,
24,
748
]
],
[
[
1083,
25,
676
],
[
676,
63,
748
]
],
[
[
1083,
24,
1683
],
[
1683,
24,
748
]
],
[
[
1083,
64,
1057
],
[
1057,
... | [
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Trifluridine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
... | Trifluridine may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekin... |
DB00377 | DB00679 | 1,494 | 684 | [
"DDInter1382",
"DDInter1796"
] | Palonosetron | Thioridazine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Major | 2 | [
[
[
1494,
25,
684
]
],
[
[
1494,
25,
1237
],
[
1237,
40,
684
]
],
[
[
1494,
24,
216
],
[
216,
1,
684
]
],
[
[
1494,
6,
12523
],
[
12523,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thioridazine"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clomipramine"
],
[
"Clomipramine",
... | Palonosetron may lead to a major life threatening interaction when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thioridazine (Compo... |
DB01044 | DB01128 | 246 | 918 | [
"DDInter809",
"DDInter204"
] | Gatifloxacin | Bicalutamide | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Major | 2 | [
[
[
246,
25,
918
]
],
[
[
246,
25,
129
],
[
129,
40,
918
]
],
[
[
246,
21,
28642
],
[
28642,
60,
918
]
],
[
[
246,
62,
112
],
[
112,
... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
]
],
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Gatifloxacin may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Gatifloxacin (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Bicalutamide (Compound)
Gatifloxacin may cause a minor interaction that can lim... |
DB00295 | DB01178 | 475 | 369 | [
"DDInter1244",
"DDInter357"
] | Morphine | Chlormezanone | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. | Major | 2 | [
[
[
475,
25,
369
]
],
[
[
475,
24,
1532
],
[
1532,
63,
369
]
],
[
[
475,
24,
272
],
[
272,
24,
369
]
],
[
[
475,
63,
701
],
[
701,
2... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Chlormezanone"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
"Ifosfamide"... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chlormezanone
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and C... |
DB00497 | DB11718 | 828 | 927 | [
"DDInter1366",
"DDInter640"
] | Oxycodone | Encorafenib | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
828,
24,
927
]
],
[
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[
1324,
24,
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],
[
1264,
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]
],
[
[
828,
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1374
],
[
1374,
... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
... | Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepi... |
DB00860 | DB11642 | 891 | 938 | [
"DDInter1513",
"DDInter1480"
] | Prednisolone | Pitolisant | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
891,
24,
938
]
],
[
[
891,
24,
760
],
[
760,
24,
938
]
],
[
[
891,
63,
600
],
[
600,
24,
938
]
],
[
[
891,
62,
1018
],
[
1018,
2... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and F... |
DB00436 | DB09038 | 323 | 1,450 | [
"DDInter179",
"DDInter636"
] | Bendroflumethiazide | Empagliflozin | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
323,
24,
1450
]
],
[
[
323,
24,
659
],
[
659,
63,
1450
]
],
[
[
323,
63,
1061
],
[
1061,
24,
1450
]
],
[
[
323,
24,
1486
],
[
1486,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilant... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00460 | DB01612 | 612 | 1,637 | [
"DDInter1929",
"DDInter92"
] | Verteporfin | Amyl Nitrite | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
612,
24,
1637
]
],
[
[
612,
24,
714
],
[
714,
24,
1637
]
],
[
[
612,
63,
1061
],
[
1061,
24,
1637
]
],
[
[
612,
24,
714
],
[
714,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
[
... | Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Trep... |
DB00456 | DB01082 | 164 | 1,448 | [
"DDInter311",
"DDInter1713"
] | Cefalotin | Streptomycin | Cefalotin is a cephalosporin antibiotic. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
164,
24,
1448
]
],
[
[
164,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
164,
24,
361
],
[
361,
24,
1448
]
],
[
[
164,
40,
1558
],
[
1558,
... | [
[
[
"Cefalotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Cefalotin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compound)... | Cefalotin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Cefalotin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin and Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Cefalotin (Compoun... |
DB00005 | DB00081 | 1,057 | 273 | [
"DDInter687",
"DDInter1838"
] | Etanercept | Tositumomab | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Major | 2 | [
[
[
1057,
25,
273
]
],
[
[
1057,
24,
1270
],
[
1270,
63,
273
]
],
[
[
1057,
25,
869
],
[
869,
63,
273
]
],
[
[
1057,
25,
1184
],
[
1184,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tositumomab"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Tositumomab
Etanercept may lead to a major life threatening interac... |
DB00054 | DB00176 | 1,432 | 529 | [
"DDInter6",
"DDInter770"
] | Abciximab | Fluvoxamine | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Moderate | 1 | [
[
[
1432,
24,
529
]
],
[
[
1432,
64,
20
],
[
20,
24,
529
]
],
[
[
1432,
24,
1274
],
[
1274,
63,
529
]
],
[
[
1432,
25,
1172
],
[
1172,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvoxamine"
]
],
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
"Tenectepl... | Abciximab may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may... |
DB00574 | DB00813 | 121 | 704 | [
"DDInter717",
"DDInter722"
] | Fenfluramine | Fentanyl | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Major | 2 | [
[
[
121,
25,
704
]
],
[
[
121,
63,
194
],
[
194,
40,
704
]
],
[
[
121,
25,
939
],
[
939,
40,
704
]
],
[
[
121,
24,
998
],
[
998,
1,
... | [
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
],
[
"Darifen... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Darifenacin and Darifenacin (Compound) resembles Fentanyl (Compound)
Fenfluramine may lead to a major life threatening interaction when taken with Benzphetamine and Benzphetamine (Compound) resembles Fentanyl (Compound)
Fenflur... |
DB00559 | DB12010 | 152 | 214 | [
"DDInter223",
"DDInter785"
] | Bosentan | Fostamatinib | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
152,
24,
214
]
],
[
[
152,
24,
976
],
[
976,
24,
214
]
],
[
[
152,
25,
866
],
[
866,
24,
214
]
],
[
[
152,
63,
10
],
[
10,
24,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Bosentan may lead to a major life threatening interaction when taken with Cobimetinib and Cobimetinib may caus... |
DB01611 | DB13007 | 1,487 | 1,060 | [
"DDInter893",
"DDInter642"
] | Hydroxychloroquine | Enfortumab vedotin | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
1487,
24,
1060
]
],
[
[
1487,
24,
1604
],
[
1604,
23,
1060
]
],
[
[
1487,
25,
1593
],
[
1593,
24,
1060
]
],
[
[
1487,
63,
590
],
[
590... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lum... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor and Lumacaftor may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Hydroxychloroquine may lead to a major life threatening interaction when taken with Crizotinib and... |
DB00959 | DB13928 | 1,486 | 1,385 | [
"DDInter1191",
"DDInter1660"
] | Methylprednisolone | Semaglutide | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1486,
24,
1385
]
],
[
[
1486,
64,
839
],
[
839,
24,
1385
]
],
[
[
1486,
24,
637
],
[
637,
24,
1385
]
],
[
[
1486,
63,
359
],
[
359,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Methylprednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Grepafloxacin"
],
... | Methylprednisolone may lead to a major life threatening interaction when taken with Grepafloxacin and Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase ... |
DB00201 | DB12332 | 1,684 | 1,619 | [
"DDInter263",
"DDInter1626"
] | Caffeine | Rucaparib | Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine].[A187691,L9851] It can be sourced from coffee beans, but ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1684,
24,
1619
]
],
[
[
1684,
24,
969
],
[
969,
24,
1619
]
],
[
[
1684,
23,
869
],
[
869,
24,
1619
]
],
[
[
1684,
24,
1399
],
[
1399,
... | [
[
[
"Caffeine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Caffeine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
],
[
"R... | Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Ramelteon and Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Caffeine may cause a minor interaction that can limit clinical effects when taken with Topotecan and Topotecan may ca... |
DB01208 | DB11986 | 945 | 484 | [
"DDInter1705",
"DDInter648"
] | Sparfloxacin | Entrectinib | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
945,
25,
484
]
],
[
[
945,
62,
112
],
[
112,
23,
484
]
],
[
[
945,
40,
1539
],
[
1539,
24,
484
]
],
[
[
945,
25,
774
],
[
774,
2... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Sparfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Sparfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Sparfloxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a moderate interaction that ... |
DB00005 | DB00851 | 1,057 | 611 | [
"DDInter687",
"DDInter463"
] | Etanercept | Dacarbazine | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Major | 2 | [
[
[
1057,
25,
611
]
],
[
[
1057,
25,
141
],
[
141,
24,
611
]
],
[
[
1057,
25,
850
],
[
850,
63,
611
]
],
[
[
1057,
24,
66
],
[
66,
2... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dacarbazine"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Floxuridine"
],
[
"Floxuridine",
"{u... | Etanercept may lead to a major life threatening interaction when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Dacarbazine
Etanercept may lead to a major life threatening interaction when taken with Brentuximab vedotin and Brentuximab vedotin may ... |
DB01105 | DB01125 | 222 | 279 | [
"DDInter1665",
"DDInter98"
] | Sibutramine | Anisindione | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
222,
24,
279
]
],
[
[
222,
63,
1647
],
[
1647,
23,
279
]
],
[
[
222,
63,
1645
],
[
1645,
24,
279
]
],
[
[
222,
62,
522
],
[
522,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Anisindione
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin ... |
DB00945 | DB09481 | 1,479 | 460 | [
"DDInter20",
"DDInter1113"
] | Acetylsalicylic acid | Magnesium carbonate | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
1479,
24,
460
]
],
[
[
1479,
63,
664
],
[
664,
23,
460
]
],
[
[
1479,
23,
1592
],
[
1592,
23,
460
]
],
[
[
1479,
62,
461
],
[
461,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Perindopril and Perindopril may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken... |
DB00794 | DB01501 | 759 | 1,118 | [
"DDInter1521",
"DDInter549"
] | Primidone | Difenoxin | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Moderate | 1 | [
[
[
759,
24,
1118
]
],
[
[
759,
24,
1688
],
[
1688,
40,
1118
]
],
[
[
759,
63,
506
],
[
506,
24,
1118
]
],
[
[
759,
1,
697
],
[
697,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenoxylate"
],
[
... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Difenoxin (Compound)
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interac... |
DB01176 | DB06691 | 537 | 849 | [
"DDInter453",
"DDInter1155"
] | Cyclizine | Mepyramine | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
537,
24,
849
]
],
[
[
537,
40,
11244
],
[
11244,
1,
849
]
],
[
[
537,
63,
1594
],
[
1594,
24,
849
]
],
[
[
537,
6,
10104
],
[
10104,
... | [
[
[
"Cyclizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Cyclizine",
"{u} (Compound) resembles {v} (Compound)",
"Pheniramine"
],
[
"Pheniramine",
"{u} (Compound) resemble... | Cyclizine (Compound) resembles Pheniramine (Compound) and Pheniramine (Compound) resembles Mepyramine (Compound)
Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
... |
DB00916 | DB12161 | 112 | 730 | [
"DDInter1202",
"DDInter512"
] | Metronidazole | Deutetrabenazine | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Minor | 0 | [
[
[
112,
23,
730
]
],
[
[
112,
62,
322
],
[
322,
24,
730
]
],
[
[
112,
23,
1559
],
[
1559,
24,
730
]
],
[
[
112,
24,
770
],
[
770,
2... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Epirubicin"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Famotidine an... |
DB01764 | DB08816 | 805 | 578 | [
"DDInter469",
"DDInter1802"
] | Dalfopristin | Ticagrelor | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
805,
24,
578
]
],
[
[
805,
6,
8374
],
[
8374,
45,
578
]
],
[
[
805,
25,
1135
],
[
1135,
62,
578
]
],
[
[
805,
63,
723
],
[
723,
... | [
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Dalfopristin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Dalfopristin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Dalfopristin may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Dalfopristin may cause a moderate... |
DB00910 | DB01045 | 1,041 | 463 | [
"DDInter1394",
"DDInter1590"
] | Paricalcitol | Rifampicin | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
1041,
24,
463
]
],
[
[
1041,
63,
690
],
[
690,
40,
463
]
],
[
[
1041,
6,
8374
],
[
8374,
45,
463
]
],
[
[
1041,
25,
115
],
[
115,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Paricalcitol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifampicin (Compound)
Paricalcitol may lead to a major life threatening interaction wh... |
DB00808 | DB00959 | 1,605 | 1,486 | [
"DDInter916",
"DDInter1191"
] | Indapamide | Methylprednisolone | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
1605,
24,
1486
]
],
[
[
1605,
63,
175
],
[
175,
40,
1486
]
],
[
[
1605,
63,
167
],
[
167,
1,
1486
]
],
[
[
1605,
24,
1220
],
[
1220,
... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB00393 | DB01164 | 854 | 803 | [
"DDInter1295",
"DDInter272"
] | Nimodipine | Calcium chloride | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in ... | Moderate | 1 | [
[
[
854,
24,
803
]
],
[
[
854,
21,
29985
],
[
29985,
60,
803
]
],
[
[
854,
1,
84
],
[
84,
24,
803
]
],
[
[
854,
21,
28809
],
[
28809,
... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium chloride"
]
],
[
[
"Nimodipine",
"{u} (Compound) causes {v} (Side Effect)",
"Vasospasm"
],
[
"Vasospasm",
"{u} (Side Effect) i... | Nimodipine (Compound) causes Vasospasm (Side Effect) and Vasospasm (Side Effect) is caused by Calcium chloride (Compound)
Nimodipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Calcium chloride
Nimodipine (Compound) causes D... |
DB00445 | DB11796 | 322 | 1,612 | [
"DDInter655",
"DDInter786"
] | Epirubicin | Fostemsavir | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
322,
24,
1612
]
],
[
[
322,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
322,
63,
1101
],
[
1101,
23,
1612
]
],
[
[
322,
23,
112
],
[
112,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarot... |
DB00860 | DB11095 | 891 | 235 | [
"DDInter1513",
"DDInter505"
] | Prednisolone | Desirudin | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
891,
25,
235
]
],
[
[
891,
24,
1004
],
[
1004,
24,
235
]
],
[
[
891,
62,
1461
],
[
1461,
24,
235
]
],
[
[
891,
63,
529
],
[
529,
... | [
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
],
[
"... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Desirudin
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Vitami... |
DB00281 | DB06448 | 608 | 171 | [
"DDInter1066",
"DDInter1087"
] | Lidocaine | Lonafarnib | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
608,
24,
171
]
],
[
[
608,
23,
1051
],
[
1051,
24,
171
]
],
[
[
608,
24,
1010
],
[
1010,
24,
171
]
],
[
[
608,
23,
98
],
[
98,
6... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aminoglutethimide"
],
[... | Lidocaine may cause a minor interaction that can limit clinical effects when taken with Aminoglutethimide and Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine ... |
DB00572 | DB08938 | 85 | 1,384 | [
"DDInter136",
"DDInter1112"
] | Atropine | Magaldrate | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
85,
24,
1384
]
],
[
[
85,
24,
1178
],
[
1178,
23,
1384
]
],
[
[
85,
63,
461
],
[
461,
23,
1384
]
],
[
[
85,
62,
1252
],
[
1252,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
[
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timol... |
DB00533 | DB09054 | 1,416 | 384 | [
"DDInter1613",
"DDInter905"
] | Rofecoxib | Idelalisib | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1416,
24,
384
]
],
[
[
1416,
63,
305
],
[
305,
24,
384
]
],
[
[
1416,
24,
891
],
[
891,
24,
384
]
],
[
[
1416,
24,
1613
],
[
1613,
... | [
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Rofecoxib may cause a moderate interaction that could exacerbate diseases w... |
DB00703 | DB11057 | 997 | 720 | [
"DDInter1167",
"DDInter1223"
] | Methazolamide | Mineral oil | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
997,
24,
720
]
],
[
[
997,
63,
175
],
[
175,
24,
720
]
],
[
[
997,
24,
1486
],
[
1486,
24,
720
]
],
[
[
997,
64,
1425
],
[
1425,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Methylpr... |
DB08931 | DB11979 | 947 | 1,320 | [
"DDInter1600",
"DDInter625"
] | Riociguat | Elagolix | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
947,
24,
1320
]
],
[
[
947,
63,
129
],
[
129,
24,
1320
]
],
[
[
947,
24,
913
],
[
913,
24,
1320
]
],
[
[
947,
24,
484
],
[
484,
... | [
[
[
"Riociguat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Riociguat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalu... |
DB00277 | DB00598 | 1,031 | 1,523 | [
"DDInter1791",
"DDInter1013"
] | Theophylline | Labetalol | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Major | 2 | [
[
[
1031,
25,
1523
]
],
[
[
1031,
24,
455
],
[
455,
64,
1523
]
],
[
[
1031,
24,
1148
],
[
1148,
63,
1523
]
],
[
[
1031,
24,
1052
],
[
1052... | [
[
[
"Theophylline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Labetalol"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
"Salmete... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may lead to a major life threatening interaction when taken with Labetalol
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may... |
DB00261 | DB06209 | 702 | 256 | [
"DDInter93",
"DDInter1508"
] | Anagrelide | Prasugrel | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Major | 2 | [
[
[
702,
25,
256
]
],
[
[
702,
21,
28792
],
[
28792,
60,
256
]
],
[
[
702,
23,
944
],
[
944,
62,
256
]
],
[
[
702,
24,
752
],
[
752,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal disorder"
],
[
"Gastrointestinal disorder",
"{u} (Side... | Anagrelide (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Prasugrel (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effect... |
DB00258 | DB00562 | 666 | 1,014 | [
"DDInter270",
"DDInter188"
] | Calcium acetate | Benzthiazide | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Moderate | 1 | [
[
[
666,
24,
1014
]
],
[
[
666,
24,
811
],
[
811,
40,
1014
]
],
[
[
666,
24,
674
],
[
674,
1,
1014
]
],
[
[
666,
24,
1572
],
[
1572,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Benzthiazide (Compound)
Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) rese... |
DB05239 | DB11828 | 866 | 1,406 | [
"DDInter425",
"DDInter1281"
] | Cobimetinib | Neratinib | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
866,
24,
1406
]
],
[
[
866,
63,
392
],
[
392,
24,
1406
]
],
[
[
866,
25,
1510
],
[
1510,
24,
1406
]
],
[
[
866,
24,
850
],
[
850,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
[
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Cobimetinib may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may c... |
DB00451 | DB00489 | 542 | 17 | [
"DDInter1064",
"DDInter1704"
] | Levothyroxine | Sotalol | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Minor | 0 | [
[
[
542,
23,
17
]
],
[
[
542,
62,
88
],
[
88,
40,
17
]
],
[
[
542,
21,
29648
],
[
29648,
60,
17
]
],
[
[
542,
62,
417
],
[
417,
23,
... | [
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sotalol"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metoprolol"
],
[
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Levothyroxine (Compound) causes Disorientation (Side Effect) and Disorientation (Side Effect) is caused by Sotalol (Compound)
Levothyroxine may cause a minor inte... |
DB00404 | DB00405 | 523 | 128 | [
"DDInter54",
"DDInter517"
] | Alprazolam | Dexbrompheniramine | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
523,
24,
128
]
],
[
[
523,
24,
662
],
[
662,
63,
128
]
],
[
[
523,
1,
686
],
[
686,
63,
128
]
],
[
[
523,
1,
902
],
[
902,
24,
... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Alprazolam (Compound) resembles Oxazepam (Compound) and Oxazepam may cause a moderate interaction ... |
DB00081 | DB06643 | 273 | 1,136 | [
"DDInter1838",
"DDInter500"
] | Tositumomab | Denosumab | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Denosumab is a novel, fully human IgG2 monoclonal antibody specific to receptor activator of nuclear factor kappa-B ligand (RANKL), suppresses bone resorption via inhibiting RANK-mediated activation of osteoclasts. It is the first and currently the only RANKL inhibitor approved to prevent osteoclast-mediated bone loss.... | Moderate | 1 | [
[
[
273,
24,
1136
]
],
[
[
273,
25,
1213
],
[
1213,
24,
1136
]
],
[
[
273,
25,
1510
],
[
1510,
63,
1136
]
],
[
[
273,
24,
270
],
[
270,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Denosumab"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
],
[
"Dasatinib"... | Tositumomab may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Denosumab
Tositumomab may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide may cause a moderate... |
DB10276 | DB11569 | 1,624 | 1,093 | [
"DDInter1623",
"DDInter1003"
] | Rotavirus vaccine | Ixekizumab | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Major | 2 | [
[
[
1624,
25,
1093
]
],
[
[
1624,
64,
66
],
[
66,
24,
1093
]
],
[
[
1624,
25,
270
],
[
270,
63,
1093
]
],
[
[
1624,
64,
1057
],
[
1057,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ixekizumab"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Efalizumab"
],
[
"Efalizumab"... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Rotavirus vaccine may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may cause... |
DB06779 | DB11095 | 365 | 235 | [
"DDInter470",
"DDInter505"
] | Dalteparin | Desirudin | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
365,
25,
235
]
],
[
[
365,
23,
297
],
[
297,
23,
235
]
],
[
[
365,
63,
1100
],
[
1100,
24,
235
]
],
[
[
365,
24,
1004
],
[
1004,
... | [
[
[
"Dalteparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Dalteparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u}... | Dalteparin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may caus... |
DB00762 | DB01337 | 613 | 1,579 | [
"DDInter973",
"DDInter1385"
] | Irinotecan | Pancuronium | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release. | Minor | 0 | [
[
[
613,
23,
1579
]
],
[
[
613,
62,
1610
],
[
1610,
1,
1579
]
],
[
[
613,
23,
728
],
[
728,
1,
1579
]
],
[
[
613,
6,
10558
],
[
10558,
... | [
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pancuronium"
]
],
[
[
"Irinotecan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rocuronium"
],
[
... | Irinotecan may cause a minor interaction that can limit clinical effects when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound)
Irinotecan may cause a minor interaction that can limit clinical effects when taken with Vecuronium and Vecuronium (Compound) resembles Pancuronium (Compound)
Ir... |
DB00250 | DB00727 | 10 | 685 | [
"DDInter475",
"DDInter1304"
] | Dapsone | Nitroglycerin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Moderate | 1 | [
[
[
10,
24,
685
]
],
[
[
10,
21,
29966
],
[
29966,
60,
685
]
],
[
[
10,
25,
1455
],
[
1455,
64,
685
]
],
[
[
10,
21,
29966
],
[
29966,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitroglycerin"
]
],
[
[
"Dapsone",
"{u} (Compound) causes {v} (Side Effect)",
"Application site reaction"
],
[
"Application site reaction",
... | Dapsone (Compound) causes Application site reaction (Side Effect) and Application site reaction (Side Effect) is caused by Nitroglycerin (Compound)
Dapsone may lead to a major life threatening interaction when taken with Nitrous acid and Nitrous acid may lead to a major life threatening interaction when taken with Nitr... |
DB00405 | DB01403 | 128 | 9 | [
"DDInter517",
"DDInter1175"
] | Dexbrompheniramine | Methotrimeprazine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
128,
24,
9
]
],
[
[
128,
24,
1178
],
[
1178,
40,
9
]
],
[
[
128,
24,
1164
],
[
1164,
1,
9
]
],
[
[
128,
24,
401
],
[
401,
24,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trif... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compo... |
DB01181 | DB01224 | 1,532 | 623 | [
"DDInter906",
"DDInter1553"
] | Ifosfamide | Quetiapine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1532,
24,
623
]
],
[
[
1532,
63,
827
],
[
827,
1,
623
]
],
[
[
1532,
64,
695
],
[
695,
1,
623
]
],
[
[
1532,
6,
6799
],
[
6799,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
],
[
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Quetiapine (Compound)
Ifosfamide may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Ifosfamide (Compoun... |
DB00563 | DB12001 | 663 | 564 | [
"DDInter1174",
"DDInter7"
] | Methotrexate | Abemaciclib | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
663,
24,
564
]
],
[
[
663,
24,
868
],
[
868,
24,
564
]
],
[
[
663,
63,
58
],
[
58,
24,
564
]
],
[
[
663,
25,
1249
],
[
1249,
24,... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and ... |
DB00641 | DB01241 | 467 | 1,206 | [
"DDInter1675",
"DDInter812"
] | Simvastatin | Gemfibrozil | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Major | 2 | [
[
[
467,
25,
1206
]
],
[
[
467,
5,
11576
],
[
11576,
44,
1206
]
],
[
[
467,
6,
8374
],
[
8374,
45,
1206
]
],
[
[
467,
7,
2473
],
[
2473,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemfibrozil"
]
],
[
[
"Simvastatin",
"{u} (Compound) treats {v} (Disease)",
"coronary artery disease"
],
[
"coronary artery disease",
"{u} (Disease)... | Simvastatin (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Gemfibrozil (Compound)
Simvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Gemfibrozil (Compound)
Simvastatin (Compound) upregulates RHOA (Gene) and RHOA (Gene) is upregulated by Gemf... |
DB00758 | DB15233 | 1,347 | 1,650 | [
"DDInter413",
"DDInter142"
] | Clopidogrel | Avapritinib | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
1347,
25,
1650
]
],
[
[
1347,
62,
522
],
[
522,
24,
1650
]
],
[
[
1347,
24,
557
],
[
557,
24,
1650
]
],
[
[
1347,
63,
121
],
[
121,
... | [
[
[
"Clopidogrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Clopidogrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zafirlukast"
],
[
"Zafirluk... | Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid a... |
DB01394 | DB04845 | 1,554 | 309 | [
"DDInter431",
"DDInter1001"
] | Colchicine | Ixabepilone | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1554,
24,
309
]
],
[
[
1554,
6,
8374
],
[
8374,
45,
309
]
],
[
[
1554,
7,
16974
],
[
16974,
45,
309
]
],
[
[
1554,
21,
28736
],
[
2873... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Colchicine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Colchicine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Colchicine (Compound) upregulates TUBB6 (Gene) and TUBB6 (Gene) is bound by Ixabepilone (Compound)
Colchicine (Compound) causes Dehydration (Side Effect) and Dehydration (Side Effect) is caused by Ixabepilone (Compound)
Colch... |
DB01268 | DB04946 | 1,151 | 924 | [
"DDInter1731",
"DDInter907"
] | Sunitinib | Iloperidone | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
1151,
25,
924
]
],
[
[
1151,
63,
1664
],
[
1664,
1,
924
]
],
[
[
1151,
64,
1425
],
[
1425,
25,
924
]
],
[
[
1151,
63,
519
],
[
519,
... | [
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
"Risperidon... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Sunitinib may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when taken... |
DB00903 | DB01001 | 1,680 | 688 | [
"DDInter686",
"DDInter1632"
] | Etacrynic acid | Salbutamol | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1680,
24,
688
]
],
[
[
1680,
24,
455
],
[
455,
24,
688
]
],
[
[
1680,
21,
28714
],
[
28714,
60,
688
]
],
[
[
1680,
24,
1220
],
[
1220,... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Etacrynic acid (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Salbutamol (... |
DB06791 | DB09073 | 1,446 | 951 | [
"DDInter1021",
"DDInter1379"
] | Lanreotide | Palbociclib | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1446,
24,
951
]
],
[
[
1446,
23,
907
],
[
907,
62,
951
]
],
[
[
1446,
24,
159
],
[
159,
63,
951
]
],
[
[
1446,
63,
761
],
[
761,
... | [
[
[
"Lanreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Lanreotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
... | Lanreotide may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Lanreotide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotr... |
DB00802 | DB01183 | 1,322 | 173 | [
"DDInter43",
"DDInter1262"
] | Alfentanil | Naloxone | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, ... | Moderate | 1 | [
[
[
1322,
24,
173
]
],
[
[
1322,
63,
475
],
[
475,
24,
173
]
],
[
[
1322,
64,
267
],
[
267,
40,
173
]
],
[
[
1322,
6,
4973
],
[
4973,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxone"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone
Alfentanil may lead to a major life threatening interaction when taken with Naltrexone and Naltrexone (Compound) resem... |
DB00601 | DB00907 | 453 | 290 | [
"DDInter1073",
"DDInter427"
] | Linezolid | Cocaine (topical) | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Major | 2 | [
[
[
453,
25,
290
]
],
[
[
453,
21,
28658
],
[
28658,
60,
290
]
],
[
[
453,
24,
1637
],
[
1637,
63,
290
]
],
[
[
453,
24,
455
],
[
455,
... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cocaine"
]
],
[
[
"Linezolid",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by {v} (Compound)",... | Linezolid may lead to a major life threatening interaction when taken with Cocaine
Linezolid (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Cocaine (Compound)
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite and Amyl Nitrite may cau... |
DB00196 | DB00222 | 600 | 245 | [
"DDInter743",
"DDInter825"
] | Fluconazole | Glimepiride | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Major | 2 | [
[
[
600,
25,
245
]
],
[
[
600,
25,
959
],
[
959,
1,
245
]
],
[
[
600,
6,
6017
],
[
6017,
45,
245
]
],
[
[
600,
21,
29024
],
[
29024,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glimepiride"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glipizide"
],
[
"Glipizide",
"{u} ... | Fluconazole may lead to a major life threatening interaction when taken with Glipizide and Glipizide (Compound) resembles Glimepiride (Compound)
Fluconazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Glimepiride (Compound)
Fluconazole (Compound) causes Hypertension (Side Effect) and Hypertension (Side... |
DB00387 | DB06691 | 1,386 | 849 | [
"DDInter1528",
"DDInter1155"
] | Procyclidine | Mepyramine | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1386,
24,
849
]
],
[
[
1386,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1386,
24,
272
],
[
272,
24,
849
]
],
[
[
1386,
24,
1116
],
[
1116,
... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine ... |
DB00023 | DB00754 | 305 | 157 | [
"DDInter127",
"DDInter696"
] | Asparaginase Escherichia coli | Ethotoin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
305,
24,
157
]
],
[
[
305,
24,
167
],
[
167,
24,
157
]
],
[
[
305,
24,
384
],
[
384,
63,
157
]
],
[
[
305,
25,
770
],
[
770,
63,... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Ethotoin
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate di... |
DB00782 | DB06691 | 1,123 | 849 | [
"DDInter1535",
"DDInter1155"
] | Propantheline | Mepyramine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1123,
24,
849
]
],
[
[
1123,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1123,
24,
272
],
[
272,
24,
849
]
],
[
[
1123,
24,
1116
],
[
1116,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramin... |
DB00092 | DB12893 | 58 | 586 | [
"DDInter40",
"DDInter1629"
] | Alefacept | Sacituzumab govitecan | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab goviteca... | Moderate | 1 | [
[
[
58,
24,
586
]
],
[
[
58,
24,
270
],
[
270,
24,
586
]
],
[
[
58,
63,
1184
],
[
1184,
24,
586
]
],
[
[
58,
25,
1377
],
[
1377,
25,... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sacituzumab govitecan"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Sacituzumab govitecan
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Anakinra a... |
DB00008 | DB08913 | 491 | 1,186 | [
"DDInter1407",
"DDInter1561"
] | Peginterferon alfa-2a | Radium Ra 223 dichloride | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
491,
24,
1186
]
],
[
[
491,
24,
134
],
[
134,
24,
1186
]
],
[
[
491,
23,
450
],
[
450,
24,
1186
]
],
[
[
491,
24,
1362
],
[
1362,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}"... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Peginterferon alfa-2a may cause a minor interaction that can limit clinical effects w... |
DB01118 | DB01177 | 33 | 77 | [
"DDInter76",
"DDInter904"
] | Amiodarone | Idarubicin | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
33,
25,
77
]
],
[
[
33,
6,
6017
],
[
6017,
45,
77
]
],
[
[
33,
7,
2703
],
[
2703,
46,
77
]
],
[
[
33,
18,
4410
],
[
4410,
57,
... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Amiodarone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Idarubi... | Amiodarone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Amiodarone (Compound) upregulates IKZF1 (Gene) and IKZF1 (Gene) is upregulated by Idarubicin (Compound)
Amiodarone (Compound) downregulates VAPB (Gene) and VAPB (Gene) is downregulated by Idarubicin (Compound)
Amiodarone (Comp... |
DB00431 | DB00831 | 1,503 | 1,178 | [
"DDInter1072",
"DDInter1866"
] | Lindane | Trifluoperazine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1503,
24,
1178
]
],
[
[
1503,
63,
695
],
[
695,
40,
1178
]
],
[
[
1503,
24,
146
],
[
146,
40,
1178
]
],
[
[
1503,
24,
9
],
[
9,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine (Compound) resembles Trifluoperazine (Comp... |
DB00207 | DB00983 | 1,570 | 480 | [
"DDInter157",
"DDInter776"
] | Azithromycin | Formoterol | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
1570,
24,
480
]
],
[
[
1570,
24,
1148
],
[
1148,
63,
480
]
],
[
[
1570,
6,
8717
],
[
8717,
45,
480
]
],
[
[
1570,
21,
28963
],
[
28963... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
... | Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Azithromycin (Compound) binds CYP2A6 (Gene) and CYP2A6 (Gene) is bound by Formoterol (Compound)
Azithromyc... |
DB00279 | DB00390 | 1,152 | 1,252 | [
"DDInter1074",
"DDInter554"
] | Liothyronine | Digoxin | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Moderate | 1 | [
[
[
1152,
24,
1252
]
],
[
[
1152,
24,
1482
],
[
1482,
40,
1252
]
],
[
[
1152,
6,
16560
],
[
16560,
45,
1252
]
],
[
[
1152,
7,
13230
],
[
1... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
]
],
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],
[
... | Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin (Compound) resembles Digoxin (Compound)
Liothyronine (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Digoxin (Compound)
Liothyronine (Compound) upregulates TIPARP (Gene) and TIPARP (Gene) ... |
DB00332 | DB00810 | 1,089 | 456 | [
"DDInter970",
"DDInter211"
] | Ipratropium | Biperiden | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Moderate | 1 | [
[
[
1089,
24,
456
]
],
[
[
1089,
24,
1105
],
[
1105,
40,
456
]
],
[
[
1089,
6,
4304
],
[
4304,
45,
456
]
],
[
[
1089,
7,
6314
],
[
6314,
... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Biperiden"
]
],
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trihexyphenidyl"
],
... | Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Trihexyphenidyl and Trihexyphenidyl (Compound) resembles Biperiden (Compound)
Ipratropium (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Biperiden (Compound)
Ipratropium (Compound) upregulates TLR4 (Gene) and TLR4 (G... |
DB08882 | DB11732 | 1,281 | 1,097 | [
"DDInter1070",
"DDInter1027"
] | Linagliptin | Lasmiditan | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1281,
24,
1097
]
],
[
[
1281,
24,
971
],
[
971,
63,
1097
]
],
[
[
1281,
63,
850
],
[
850,
24,
1097
]
],
[
[
1281,
63,
222
],
[
222,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab ved... |
DB00586 | DB00661 | 1,512 | 122 | [
"DDInter537",
"DDInter1928"
] | Diclofenac | Verapamil | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Minor | 0 | [
[
[
1512,
23,
122
]
],
[
[
1512,
10,
11610
],
[
11610,
44,
122
]
],
[
[
1512,
6,
10417
],
[
10417,
45,
122
]
],
[
[
1512,
21,
28809
],
[
2... | [
[
[
"Diclofenac",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Verapamil"
]
],
[
[
"Diclofenac",
"{u} (Compound) palliates {v} (Disease)",
"migraine"
],
[
"migraine",
"{u} (Disease) is treated by {v}... | Diclofenac (Compound) palliates migraine (Disease) and migraine (Disease) is treated by Verapamil (Compound)
Diclofenac (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Verapamil (Compound)
Diclofenac (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Verapamil (Compound)
Diclo... |
DB00660 | DB00719 | 1,470 | 1,219 | [
"DDInter1163",
"DDInter149"
] | Metaxalone | Azatadine | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1470,
24,
1219
]
],
[
[
1470,
63,
13
],
[
13,
24,
1219
]
],
[
[
1470,
24,
1376
],
[
1376,
63,
1219
]
],
[
[
1470,
64,
475
],
[
475,
... | [
[
[
"Metaxalone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Metaxalone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[... | Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Metaxalone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramin... |
DB00816 | DB01309 | 1,674 | 1,254 | [
"DDInter1346",
"DDInter933"
] | Orciprenaline | Insulin glulisine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1674,
24,
1254
]
],
[
[
1674,
63,
1424
],
[
1424,
24,
1254
]
],
[
[
1674,
62,
167
],
[
167,
24,
1254
]
],
[
[
1674,
24,
280
],
[
280,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
]... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Orciprenaline may cause a minor interaction that can limit clinical effects when taken with Hydrocortisone a... |
DB00209 | DB00726 | 352 | 1,164 | [
"DDInter1886",
"DDInter1876"
] | Trospium | Trimipramine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
352,
24,
1164
]
],
[
[
352,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1164
]
],
[
[
352,
21,
29305
],
[
2930... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Trimipramine (Compound)
Trospium (Compound) causes Dysgeusia (Side Effect) and Dysgeus... |
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