drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01254 | DB09068 | 1,213 | 1,427 | [
"DDInter484",
"DDInter1948"
] | Dasatinib | Vortioxetine | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1213,
24,
1427
]
],
[
[
1213,
24,
1320
],
[
1320,
63,
1427
]
],
[
[
1213,
64,
25
],
[
25,
24,
1427
]
],
[
[
1213,
25,
256
],
[
256,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Dasatinib may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause ... |
DB00862 | DB01097 | 1,005 | 1,377 | [
"DDInter1918",
"DDInter1033"
] | Vardenafil | Leflunomide | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Moderate | 1 | [
[
[
1005,
24,
1377
]
],
[
[
1005,
21,
29231
],
[
29231,
60,
1377
]
],
[
[
1005,
63,
1144
],
[
1144,
24,
1377
]
],
[
[
1005,
24,
112
],
[
1... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Leflunomide"
]
],
[
[
"Vardenafil",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} (Side ... | Vardenafil (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Leflunomide (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when t... |
DB00647 | DB08875 | 675 | 1,618 | [
"DDInter528",
"DDInter262"
] | Dextropropoxyphene | Cabozantinib | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
675,
25,
1618
]
],
[
[
675,
23,
112
],
[
112,
23,
1618
]
],
[
[
675,
40,
307
],
[
307,
24,
1618
]
],
[
[
675,
24,
1662
],
[
1662,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Dextropropoxyphene (Compound) resembles Modafinil (Compound) and Modafinil may cause a moderate inte... |
DB00241 | DB09570 | 288 | 1,480 | [
"DDInter257",
"DDInter1002"
] | Butalbital | Ixazomib | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
288,
24,
1480
]
],
[
[
288,
24,
310
],
[
310,
24,
1480
]
],
[
[
288,
40,
1023
],
[
1023,
24,
1480
]
],
[
[
288,
24,
214
],
[
214,
... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Butalbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital may cause a moderate interaction that... |
DB01583 | DB06792 | 624 | 1,606 | [
"DDInter1075",
"DDInter1023"
] | Liotrix | Lanthanum carbonate | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
624,
24,
1606
]
],
[
[
624,
40,
1152
],
[
1152,
24,
1606
]
],
[
[
624,
24,
428
],
[
428,
63,
1606
]
],
[
[
624,
1,
542
],
[
542,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Liotrix",
"{u} (Compound) resembles {v} (Compound)",
"Liothyronine"
],
[
"Liothyronine",
"{u} may cause a ... | Liotrix (Compound) resembles Liothyronine (Compound) and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate int... |
DB00580 | DB01082 | 311 | 1,448 | [
"DDInter1910",
"DDInter1713"
] | Valdecoxib | Streptomycin | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
311,
24,
1448
]
],
[
[
311,
24,
1272
],
[
1272,
63,
1448
]
],
[
[
311,
63,
91
],
[
91,
24,
1448
]
],
[
[
311,
24,
1479
],
[
1479,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
],
[... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine and Flucytosine may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Va... |
DB00938 | DB01149 | 455 | 851 | [
"DDInter1635",
"DDInter1274"
] | Salmeterol | Nefazodone | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Major | 2 | [
[
[
455,
25,
851
]
],
[
[
455,
63,
252
],
[
252,
40,
851
]
],
[
[
455,
63,
1178
],
[
1178,
1,
851
]
],
[
[
455,
24,
673
],
[
673,
40... | [
[
[
"Salmeterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[
"Hydroxyzi... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Nefazodone (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Nefazodone... |
DB00564 | DB09065 | 1,236 | 760 | [
"DDInter293",
"DDInter424"
] | Carbamazepine | Cobicistat | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1236,
25,
760
]
],
[
[
1236,
62,
1101
],
[
1101,
23,
760
]
],
[
[
1236,
25,
1374
],
[
1374,
23,
760
]
],
[
[
1236,
24,
1041
],
[
1041,... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Carbamazepine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Carbamazepine may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Carbamazepine may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may ca... |
DB00046 | DB00960 | 1,179 | 887 | [
"DDInter940",
"DDInter1471"
] | Insulin lispro | Pindolol | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Moderate | 1 | [
[
[
1179,
24,
887
]
],
[
[
1179,
24,
819
],
[
819,
40,
887
]
],
[
[
1179,
24,
1148
],
[
1148,
63,
887
]
],
[
[
1179,
24,
1121
],
[
1121,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction ... |
DB00604 | DB01064 | 1,425 | 1,148 | [
"DDInter385",
"DDInter987"
] | Cisapride | Isoprenaline | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Major | 2 | [
[
[
1425,
25,
1148
]
],
[
[
1425,
24,
480
],
[
480,
24,
1148
]
],
[
[
1425,
64,
534
],
[
534,
24,
1148
]
],
[
[
1425,
25,
1151
],
[
1151,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isoprenaline"
]
],
[
[
"Cisapride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol... | Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Cisapride may lead to a major life threatening interaction when taken with Tramadol and Tramadol may cause a mo... |
DB01066 | DB01390 | 1,462 | 1,117 | [
"DDInter316",
"DDInter1683"
] | Cefditoren | Sodium bicarbonate | Cefditoren is an oral third-generation cephalosporin. It is commonly marketed under the trade name Spectracef by Cornerstone BioPharma. | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Moderate | 1 | [
[
[
1462,
24,
1117
]
],
[
[
1462,
63,
1127
],
[
1127,
23,
1117
]
],
[
[
1462,
1,
665
],
[
665,
24,
1117
]
],
[
[
1462,
63,
1096
],
[
1096,... | [
[
[
"Cefditoren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Cefditoren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nizatidine"
],
... | Cefditoren may cause a moderate interaction that could exacerbate diseases when taken with Nizatidine and Nizatidine may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbonate
Cefditoren (Compound) resembles Cefuroxime (Compound) and Cefuroxime may cause a moderate interaction that... |
DB00986 | DB01100 | 1,192 | 1,568 | [
"DDInter834",
"DDInter1470"
] | Glycopyrronium | Pimozide | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
1192,
24,
1568
]
],
[
[
1192,
6,
4304
],
[
4304,
45,
1568
]
],
[
[
1192,
18,
8386
],
[
8386,
46,
1568
]
],
[
[
1192,
21,
29024
],
[
29... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Glycopyrronium",
"{u} (Compound) binds {v} (Gene)",
"CHRM2"
],
[
"CHRM2",
"{u} (Gene) is bound by {v} (Compoun... | Glycopyrronium (Compound) binds CHRM2 (Gene) and CHRM2 (Gene) is bound by Pimozide (Compound)
Glycopyrronium (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Pimozide (Compound)
Glycopyrronium (Compound) causes Hypertension (Side Effect) and Hypertension (Side Effect) is caused by Pimozide (Co... |
DB01021 | DB09134 | 674 | 1,552 | [
"DDInter1861",
"DDInter966"
] | Trichlormethiazide | Ioversol | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
674,
24,
1552
]
],
[
[
674,
1,
1577
],
[
1577,
24,
1552
]
],
[
[
674,
63,
1648
],
[
1648,
24,
1552
]
],
[
[
674,
40,
1326
],
[
1326,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Trichlormethiazide",
"{u} (Compound) resembles {v} (Compound)",
"Hydroflumethiazide"
],
[
"Hydroflumethiazide",
... | Trichlormethiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a... |
DB00377 | DB09268 | 1,494 | 1,662 | [
"DDInter1382",
"DDInter1464"
] | Palonosetron | Picosulfuric acid | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1494,
24,
1662
]
],
[
[
1494,
25,
1164
],
[
1164,
24,
1662
]
],
[
[
1494,
24,
484
],
[
484,
63,
1662
]
],
[
[
1494,
24,
1491
],
[
1491... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimipramine"
],
[
... | Palonosetron may lead to a major life threatening interaction when taken with Trimipramine and Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entre... |
DB01156 | DB01579 | 593 | 341 | [
"DDInter252",
"DDInter1439"
] | Bupropion | Phendimetrazine | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Major | 2 | [
[
[
593,
25,
341
]
],
[
[
593,
5,
11585
],
[
11585,
44,
341
]
],
[
[
593,
6,
2437
],
[
2437,
45,
341
]
],
[
[
593,
21,
28662
],
[
28662,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Bupropion",
"{u} (Compound) treats {v} (Disease)",
"obesity"
],
[
"obesity",
"{u} (Disease) is treated by {v} (Compound)",
... | Bupropion (Compound) treats obesity (Disease) and obesity (Disease) is treated by Phendimetrazine (Compound)
Bupropion (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Phendimetrazine (Compound)
Bupropion (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Phendimetrazine (Compound)... |
DB01610 | DB06589 | 248 | 1,250 | [
"DDInter1912",
"DDInter1400"
] | Valganciclovir | Pazopanib | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
248,
24,
1250
]
],
[
[
248,
21,
29264
],
[
29264,
60,
1250
]
],
[
[
248,
63,
1419
],
[
1419,
24,
1250
]
],
[
[
248,
24,
4
],
[
4,
... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Valganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Rhinorrhoea"
],
[
"Rhinorrhoea",
"{u} (Side Effe... | Valganciclovir (Compound) causes Rhinorrhoea (Side Effect) and Rhinorrhoea (Side Effect) is caused by Pazopanib (Compound)
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00065 | DB01041 | 581 | 770 | [
"DDInter923",
"DDInter1789"
] | Infliximab | Thalidomide | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
581,
25,
770
]
],
[
[
581,
25,
1668
],
[
1668,
1,
770
]
],
[
[
581,
25,
4
],
[
4,
63,
770
]
],
[
[
581,
24,
1401
],
[
1401,
24,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenalidomide"
],
[
"Lenalidomide",
"... | Infliximab may lead to a major life threatening interaction when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Infliximab may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that ... |
DB00364 | DB00420 | 417 | 508 | [
"DDInter1717",
"DDInter1532"
] | Sucralfate | Promazine | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Minor | 0 | [
[
[
417,
23,
508
]
],
[
[
417,
23,
146
],
[
146,
40,
508
]
],
[
[
417,
23,
1630
],
[
1630,
1,
508
]
],
[
[
417,
24,
1296
],
[
1296,
... | [
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Promazine"
]
],
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Propiomazine"
],
[
... | Sucralfate may cause a minor interaction that can limit clinical effects when taken with Propiomazine and Propiomazine (Compound) resembles Promazine (Compound)
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Perphenazine and Perphenazine (Compound) resembles Promazine (Compound... |
DB00358 | DB12825 | 1,010 | 1,375 | [
"DDInter1140",
"DDInter1032"
] | Mefloquine | Lefamulin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Major | 2 | [
[
[
1010,
25,
1375
]
],
[
[
1010,
23,
112
],
[
112,
23,
1375
]
],
[
[
1010,
24,
159
],
[
159,
63,
1375
]
],
[
[
1010,
63,
1101
],
[
1101,
... | [
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lefamulin"
]
],
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Mefloquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lefamulin
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and La... |
DB00289 | DB00927 | 847 | 1,559 | [
"DDInter132",
"DDInter712"
] | Atomoxetine | Famotidine | Atomoxetine is a selective norepinephrine (NE) reuptake inhibitor used for the treatment of attention deficit hyperactivity disorder (ADHD). Also known as the marketed product Strattera, atomoxetine is used with other treatment modalities (psychological, educational, cognitive behaviour therapy, etc) to improve develop... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
847,
24,
1559
]
],
[
[
847,
6,
10215
],
[
10215,
45,
1559
]
],
[
[
847,
21,
28747
],
[
28747,
60,
1559
]
],
[
[
847,
1,
935
],
[
935,
... | [
[
[
"Atomoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Atomoxetine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compoun... | Atomoxetine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Famotidine (Compound)
Atomoxetine (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Famotidine (Compound)
Atomoxetine (Compound) resembles Ketoprofen (Compound) and Ketoprofen may cause a minor interaction th... |
DB00342 | DB11730 | 1,181 | 351 | [
"DDInter1770",
"DDInter1588"
] | Terfenadine | Ribociclib | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1181,
25,
351
]
],
[
[
1181,
23,
1247
],
[
1247,
23,
351
]
],
[
[
1181,
24,
283
],
[
283,
62,
351
]
],
[
[
1181,
24,
479
],
[
479,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulf... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib ... |
DB01174 | DB05294 | 697 | 1,069 | [
"DDInter1442",
"DDInter1917"
] | Phenobarbital | Vandetanib | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Moderate | 1 | [
[
[
697,
24,
1069
]
],
[
[
697,
63,
1195
],
[
1195,
40,
1069
]
],
[
[
697,
6,
10417
],
[
10417,
45,
1069
]
],
[
[
697,
21,
28719
],
[
2871... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
]
],
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
... | Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Phenobarbital (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Vandetanib (Compound)
Phenobarbital (Compound) causes Pain (Side Effect) and Pain (Sid... |
DB00281 | DB14723 | 608 | 159 | [
"DDInter1066",
"DDInter1026"
] | Lidocaine | Larotrectinib | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
608,
24,
159
]
],
[
[
608,
24,
1375
],
[
1375,
24,
159
]
],
[
[
608,
23,
98
],
[
98,
24,
159
]
],
[
[
608,
63,
494
],
[
494,
24,... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin and Lefamulin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib
Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somatrem and Somatrem ma... |
DB00468 | DB15982 | 1,424 | 1,339 | [
"DDInter1557",
"DDInter193"
] | Quinine | Berotralstat | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Major | 2 | [
[
[
1424,
25,
1339
]
],
[
[
1424,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
1424,
24,
283
],
[
283,
23,
1339
]
],
[
[
1424,
24,
1213
],
[
1213... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Berotralstat"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib m... |
DB09098 | DB15035 | 98 | 503 | [
"DDInter1700",
"DDInter1959"
] | Somatrem | Zanubrutinib | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate. Such discussion revolves around whether patients' natural dispo... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Moderate | 1 | [
[
[
98,
24,
503
]
],
[
[
98,
63,
868
],
[
868,
24,
503
]
],
[
[
98,
24,
1320
],
[
1320,
24,
503
]
],
[
[
98,
64,
1101
],
[
1101,
24,... | [
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Somatrem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
... | Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Somatrem may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix... |
DB01263 | DB01268 | 859 | 1,151 | [
"DDInter1494",
"DDInter1731"
] | Posaconazole | Sunitinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
859,
24,
1151
]
],
[
[
859,
63,
1311
],
[
1311,
1,
1151
]
],
[
[
859,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
859,
21,
29662
],
[
29662,
... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
... | Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Posaconazole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Posaconazole (Compound) causes Candida infection (Side Eff... |
DB01089 | DB01309 | 1,340 | 1,254 | [
"DDInter502",
"DDInter933"
] | Deserpidine | Insulin glulisine | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1340,
24,
1254
]
],
[
[
1340,
63,
167
],
[
167,
24,
1254
]
],
[
[
1340,
24,
1220
],
[
1220,
24,
1254
]
],
[
[
1340,
24,
1450
],
[
1450... | [
[
[
"Deserpidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Deserpidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
... | Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Deserpidine may cause a moderate interaction that could exacerbate diseases when taken with Dexa... |
DB00278 | DB04932 | 291 | 1,564 | [
"DDInter117",
"DDInter491"
] | Argatroban | Defibrotide | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Major | 2 | [
[
[
291,
25,
1564
]
],
[
[
291,
23,
297
],
[
297,
62,
1564
]
],
[
[
291,
24,
914
],
[
914,
24,
1564
]
],
[
[
291,
24,
41
],
[
41,
63... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
]
],
[
[
"Argatroban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{... | Argatroban may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Defibrotide
Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may caus... |
DB00938 | DB00983 | 455 | 480 | [
"DDInter1635",
"DDInter776"
] | Salmeterol | Formoterol | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Moderate | 1 | [
[
[
455,
24,
480
]
],
[
[
455,
24,
1148
],
[
1148,
63,
480
]
],
[
[
455,
64,
1523
],
[
1523,
25,
480
]
],
[
[
455,
40,
1188
],
[
1188,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Formoterol
Salmeterol may lead to a major life threatening interaction when taken with Labetalol and Labetalol may lead... |
DB00280 | DB09564 | 494 | 1,296 | [
"DDInter575",
"DDInter930"
] | Disopyramide | Insulin degludec | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
494,
24,
1296
]
],
[
[
494,
25,
1621
],
[
1621,
23,
1296
]
],
[
[
494,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
494,
25,
1151
],
[
1151,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
],
[... | Disopyramide may lead to a major life threatening interaction when taken with Potassium chloride and Potassium chloride may cause a minor interaction that can limit clinical effects when taken with Insulin degludec
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide ... |
DB00656 | DB00757 | 827 | 1,166 | [
"DDInter1851",
"DDInter581"
] | Trazodone | Dolasetron | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Major | 2 | [
[
[
827,
25,
1166
]
],
[
[
827,
6,
12523
],
[
12523,
45,
1166
]
],
[
[
827,
21,
28803
],
[
28803,
60,
1166
]
],
[
[
827,
23,
112
],
[
112,... | [
[
[
"Trazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
]
],
[
[
"Trazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Dolasetro... | Trazodone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Dolasetron (Compound)
Trazodone (Compound) causes Anaemia (Side Effect) and Anaemia (Side Effect) is caused by Dolasetron (Compound)
Trazodone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidaz... |
DB01238 | DB08899 | 673 | 129 | [
"DDInter118",
"DDInter649"
] | Aripiprazole | Enzalutamide | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
673,
24,
129
]
],
[
[
673,
63,
918
],
[
918,
1,
129
]
],
[
[
673,
6,
8374
],
[
8374,
45,
129
]
],
[
[
673,
21,
29377
],
[
29377,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Aripiprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Aripiprazole (Compound) causes Musculoskeletal pain (S... |
DB05773 | DB11703 | 1,047 | 405 | [
"DDInter1848",
"DDInter9"
] | Trastuzumab emtansine | Acalabrutinib | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1047,
25,
405
]
],
[
[
1047,
63,
383
],
[
383,
24,
405
]
],
[
[
1047,
24,
643
],
[
643,
24,
405
]
],
[
[
1047,
24,
327
],
[
327,
... | [
[
[
"Trastuzumab emtansine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulf... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Trastuzumab emtansine may cause a moderate interaction that could exacerbate d... |
DB00631 | DB08889 | 372 | 350 | [
"DDInter405",
"DDInter299"
] | Clofarabine | Carfilzomib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
372,
24,
350
]
],
[
[
372,
21,
28762
],
[
28762,
60,
350
]
],
[
[
372,
24,
1270
],
[
1270,
63,
350
]
],
[
[
372,
63,
482
],
[
482,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Clofarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cau... | Clofarabine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interacti... |
DB01073 | DB09054 | 1,488 | 384 | [
"DDInter745",
"DDInter905"
] | Fludarabine | Idelalisib | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1488,
24,
384
]
],
[
[
1488,
63,
328
],
[
328,
24,
384
]
],
[
[
1488,
24,
788
],
[
788,
24,
384
]
],
[
[
1488,
24,
287
],
[
287,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
],
... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Pitavastati... |
DB01764 | DB08901 | 805 | 1,468 | [
"DDInter469",
"DDInter1492"
] | Dalfopristin | Ponatinib | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
805,
24,
1468
]
],
[
[
805,
24,
478
],
[
478,
24,
1468
]
],
[
[
805,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
805,
63,
1215
],
[
1215,
... | [
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Dalfopristin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Dalfopristin may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Dalfopristin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Dalfopristin may c... |
DB06176 | DB08868 | 1,342 | 1,011 | [
"DDInter1616",
"DDInter737"
] | Romidepsin | Fingolimod | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1342,
25,
1011
]
],
[
[
1342,
62,
1247
],
[
1247,
23,
1011
]
],
[
[
1342,
24,
144
],
[
144,
63,
1011
]
],
[
[
1342,
63,
867
],
[
867,
... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfam... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol an... |
DB00307 | DB15091 | 1,101 | 676 | [
"DDInter202",
"DDInter1901"
] | Bexarotene | Upadacitinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1101,
25,
676
]
],
[
[
1101,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1101,
23,
1249
],
[
1249,
24,
676
]
],
[
[
1101,
25,
1654
],
[
1654,... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Nafcillin and Naf... |
DB00586 | DB06717 | 1,512 | 875 | [
"DDInter537",
"DDInter778"
] | Diclofenac | Fosaprepitant | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
1512,
24,
875
]
],
[
[
1512,
24,
723
],
[
723,
1,
875
]
],
[
[
1512,
21,
29340
],
[
29340,
60,
875
]
],
[
[
1512,
24,
222
],
[
222,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Diclofenac (Compound) causes Stevens-Johnson syndrome (Side Effect) and Stevens-Johnson syndrome (Side Effect) is caused by Fosaprepitant (Compound)
Diclofen... |
DB01059 | DB08871 | 956 | 36 | [
"DDInter1313",
"DDInter666"
] | Norfloxacin | Eribulin | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
956,
24,
36
]
],
[
[
956,
23,
1488
],
[
1488,
24,
36
]
],
[
[
956,
63,
1424
],
[
1424,
24,
36
]
],
[
[
956,
24,
820
],
[
820,
24... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Norfloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludarabine"
],
[
... | Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine m... |
DB00982 | DB01320 | 1,517 | 651 | [
"DDInter991",
"DDInter783"
] | Isotretinoin | Fosphenytoin | Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.[Label] It was most widely marketed under the brand name Accutane, which has since been discontinued. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
1517,
24,
651
]
],
[
[
1517,
63,
362
],
[
362,
1,
651
]
],
[
[
1517,
21,
29028
],
[
29028,
60,
651
]
],
[
[
1517,
64,
1101
],
[
1101,
... | [
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Isotretinoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Isotretinoin may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Isotretinoin (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Fosphenytoin (Compound)
Isotretinoin may lead to a m... |
DB00496 | DB00748 | 194 | 662 | [
"DDInter480",
"DDInter297"
] | Darifenacin | Carbinoxamine | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Moderate | 1 | [
[
[
194,
24,
662
]
],
[
[
194,
63,
1594
],
[
1594,
24,
662
]
],
[
[
194,
6,
8374
],
[
8374,
45,
662
]
],
[
[
194,
21,
28921
],
[
28921,
... | [
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
]
],
[
[
"Darifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Darifenacin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine
Darifenacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Carbinoxamine (Compound)
Darifenaci... |
DB00054 | DB01105 | 1,432 | 222 | [
"DDInter6",
"DDInter1665"
] | Abciximab | Sibutramine | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1432,
24,
222
]
],
[
[
1432,
25,
802
],
[
802,
63,
222
]
],
[
[
1432,
24,
1027
],
[
1027,
24,
222
]
],
[
[
1432,
25,
126
],
[
126,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
],
[
"Tinzaparin"... | Abciximab may lead to a major life threatening interaction when taken with Tinzaparin and Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam may cause a m... |
DB00195 | DB09333 | 726 | 278 | [
"DDInter198",
"DDInter963"
] | Betaxolol (ophthalmic) | Iopodic acid | Betaxolol is a propanolamine that is 3-aminopropane-1,2-diol in which the hydrogen of the primary hydoxy is substituted by a 4-[2-(cyclopropylmethoxy)ethyl]phenyl group and one of the hydrogens attached to the amino group is substituted by isopropyl. It is a selective beta1-receptor blocker and is used in the treatment... | Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a radiopaque property. It was devel... | Moderate | 1 | [
[
[
726,
24,
278
]
],
[
[
726,
24,
1527
],
[
1527,
24,
278
]
],
[
[
726,
1,
887
],
[
887,
24,
278
]
],
[
[
726,
24,
1527
],
[
1527,
... | [
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
]
],
[
[
"Betaxolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
],
... | Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid
Betaxolol may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid and Iothalamic acid may cause a moderate interaction that could exacerbate diseases when taken with Iopodic aci... |
DB06810 | DB10315 | 397 | 1,137 | [
"DDInter1484",
"DDInter1127"
] | Plicamycin | Measles virus vaccine live attenuated | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Major | 2 | [
[
[
397,
25,
1137
]
],
[
[
397,
64,
581
],
[
581,
25,
1137
]
],
[
[
397,
24,
384
],
[
384,
25,
1137
]
],
[
[
397,
63,
1184
],
[
1184,
... | [
[
[
"Plicamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Measles virus vaccine live attenuated"
]
],
[
[
"Plicamycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Infliximab"
],
[
... | Plicamycin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major life threatening interaction when taken with Measles virus vaccine live attenuated
Plicamycin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB01087 | DB01255 | 1,520 | 633 | [
"DDInter1520",
"DDInter1078"
] | Primaquine | Lisdexamfetamine | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
1520,
24,
633
]
],
[
[
1520,
21,
28722
],
[
28722,
60,
633
]
],
[
[
1520,
62,
112
],
[
112,
23,
633
]
],
[
[
1520,
63,
1494
],
[
1494,... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Primaquine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caus... | Primaquine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lisdexamfetamine (Compound)
Primaquine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lisde... |
DB00238 | DB00877 | 188 | 629 | [
"DDInter1285",
"DDInter1678"
] | Nevirapine | Sirolimus | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
188,
24,
629
]
],
[
[
188,
6,
7524
],
[
7524,
45,
629
]
],
[
[
188,
21,
29203
],
[
29203,
60,
629
]
],
[
[
188,
25,
1476
],
[
1476,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Nevirapine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Sirolimus (Compound)
Nevirapine (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Sirolimus (Compound)
Nevirapine may lead to a major life threatening interactio... |
DB09104 | DB11943 | 286 | 255 | [
"DDInter1118",
"DDInter495"
] | Magnesium hydroxide | Delafloxacin | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Moderate | 1 | [
[
[
286,
24,
255
]
],
[
[
286,
62,
60
],
[
60,
23,
255
]
],
[
[
286,
63,
613
],
[
613,
23,
255
]
],
[
[
286,
63,
1283
],
[
1283,
24,... | [
[
[
"Magnesium hydroxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delafloxacin"
]
],
[
[
"Magnesium hydroxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capecitab... | Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Magnesium hydroxide may cause a moderate interaction that could exacerbate diseases when taken with I... |
DB00284 | DB00734 | 1,647 | 1,664 | [
"DDInter11",
"DDInter1605"
] | Acarbose | Risperidone | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
1647,
24,
1664
]
],
[
[
1647,
24,
924
],
[
924,
40,
1664
]
],
[
[
1647,
21,
28787
],
[
28787,
60,
1664
]
],
[
[
1647,
24,
1616
],
[
16... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Acarbose (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Risperidone (Compound)
Acarbose may cause a moderate interaction ... |
DB01225 | DB06186 | 500 | 1,439 | [
"DDInter645",
"DDInter969"
] | Enoxaparin | Ipilimumab | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Major | 2 | [
[
[
500,
25,
1439
]
],
[
[
500,
24,
1412
],
[
1412,
63,
1439
]
],
[
[
500,
63,
1560
],
[
1560,
24,
1439
]
],
[
[
500,
25,
1468
],
[
1468,
... | [
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ipilimumab"
]
],
[
[
"Enoxaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
],
[
"Ca... | Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol and Calaspargase pegol may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Pegas... |
DB00175 | DB06186 | 681 | 1,439 | [
"DDInter1509",
"DDInter969"
] | Pravastatin | Ipilimumab | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Moderate | 1 | [
[
[
681,
24,
1439
]
],
[
[
681,
63,
912
],
[
912,
24,
1439
]
],
[
[
681,
24,
482
],
[
482,
24,
1439
]
],
[
[
681,
24,
310
],
[
310,
... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ipilimumab"
]
],
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon beta-1a"
]... | Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Interferon beta-1a and Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Tio... |
DB00836 | DB06663 | 543 | 1,154 | [
"DDInter1088",
"DDInter1398"
] | Loperamide | Pasireotide | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
543,
24,
1154
]
],
[
[
543,
63,
1314
],
[
1314,
40,
1154
]
],
[
[
543,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
543,
24,
112
],
[
112,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Pasireotide (Compound)
Loperamide (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Loperamide may cause a moder... |
DB11760 | DB14783 | 119 | 287 | [
"DDInter1742",
"DDInter574"
] | Talazoparib | Diroximel fumarate | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
119,
24,
287
]
],
[
[
119,
63,
384
],
[
384,
24,
287
]
],
[
[
119,
24,
1619
],
[
1619,
24,
287
]
],
[
[
119,
64,
1510
],
[
1510,
... | [
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Talazoparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]... | Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib a... |
DB00288 | DB00731 | 1,103 | 1,144 | [
"DDInter63",
"DDInter1269"
] | Amcinonide | Nateglinide | Amcinonide is a corticosteroid. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Minor | 0 | [
[
[
1103,
23,
1144
]
],
[
[
1103,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
1103,
23,
1021
],
[
1021,
63,
1144
]
],
[
[
1103,
40,
870
],
[
8... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nateglinide"
]
],
[
[
"Amcinonide",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is cau... | Amcinonide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Amcinonide may cause a minor interaction that can limit clinical effects when taken with Pramlintide and Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Nate... |
DB00861 | DB14740 | 914 | 771 | [
"DDInter551",
"DDInter881"
] | Diflunisal | Hyaluronidase | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
914,
23,
771
]
],
[
[
914,
63,
167
],
[
167,
23,
771
]
],
[
[
914,
24,
617
],
[
617,
23,
771
]
],
[
[
914,
63,
167
],
[
167,
24,... | [
[
[
"Diflunisal",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Diflunisal",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Budesonide a... |
DB00207 | DB09020 | 1,570 | 28 | [
"DDInter157",
"DDInter212"
] | Azithromycin | Bisacodyl | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1570,
24,
28
]
],
[
[
1570,
18,
7380
],
[
7380,
46,
28
]
],
[
[
1570,
7,
9242
],
[
9242,
46,
28
]
],
[
[
1570,
18,
10144
],
[
10144,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Azithromycin",
"{u} (Compound) downregulates {v} (Gene)",
"AKAP8L"
],
[
"AKAP8L",
"{u} (Gene) is upregulated by... | Azithromycin (Compound) downregulates AKAP8L (Gene) and AKAP8L (Gene) is upregulated by Bisacodyl (Compound)
Azithromycin (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Bisacodyl (Compound)
Azithromycin (Compound) downregulates ETFB (Gene) and ETFB (Gene) is downregulated by Bisacodyl (Compound)
A... |
DB00471 | DB00731 | 201 | 1,144 | [
"DDInter1242",
"DDInter1269"
] | Montelukast | Nateglinide | Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. The medication is a member of the leukotriene receptor antagonist (LTRA) category of drugs.[L6301,L6304,L6307,L6310,L6325,L6328,L6331] Although capable of demonstrating effectiveness, the use of such LTRAs like montel... | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
201,
24,
1144
]
],
[
[
201,
6,
6017
],
[
6017,
45,
1144
]
],
[
[
201,
21,
28787
],
[
28787,
60,
1144
]
],
[
[
201,
24,
804
],
[
804,
... | [
[
[
"Montelukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Montelukast",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound... | Montelukast (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nateglinide (Compound)
Montelukast (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Nateglinide (Compound)
Montelukast may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazo... |
DB00197 | DB00641 | 1,324 | 467 | [
"DDInter1881",
"DDInter1675"
] | Troglitazone | Simvastatin | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
1324,
24,
467
]
],
[
[
1324,
24,
1152
],
[
1152,
23,
467
]
],
[
[
1324,
24,
126
],
[
126,
62,
467
]
],
[
[
1324,
24,
800
],
[
800,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine may cause a minor interaction that can limit clinical effects when taken with Simvastatin
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and W... |
DB00653 | DB01165 | 544 | 1,539 | [
"DDInter1120",
"DDInter1325"
] | Magnesium sulfate | Ofloxacin | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
544,
24,
1539
]
],
[
[
544,
63,
1467
],
[
1467,
1,
1539
]
],
[
[
544,
24,
945
],
[
945,
40,
1539
]
],
[
[
544,
24,
739
],
[
739,
... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxacin"
... | Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin... |
DB00694 | DB00831 | 51 | 1,178 | [
"DDInter485",
"DDInter1866"
] | Daunorubicin | Trifluoperazine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
51,
24,
1178
]
],
[
[
51,
64,
695
],
[
695,
40,
1178
]
],
[
[
51,
24,
851
],
[
851,
40,
1178
]
],
[
[
51,
24,
9
],
[
9,
1,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
],
[
"Cl... | Daunorubicin may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Trifluoperazine (Compound)
Dau... |
DB00975 | DB06605 | 1,317 | 1,409 | [
"DDInter573",
"DDInter108"
] | Dipyridamole | Apixaban | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1317,
25,
1409
]
],
[
[
1317,
6,
4973
],
[
4973,
45,
1409
]
],
[
[
1317,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
1317,
23,
539
],
[
53... | [
[
[
"Dipyridamole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Dipyridamole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Apixaba... | Dipyridamole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Apixaban (Compound)
Dipyridamole (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Dipyridamole may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsic... |
DB00377 | DB00708 | 1,494 | 1,454 | [
"DDInter1382",
"DDInter1718"
] | Palonosetron | Sufentanil | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Major | 2 | [
[
[
1494,
25,
1454
]
],
[
[
1494,
25,
704
],
[
704,
40,
1454
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
1454
]
],
[
[
1494,
21,
28658
],
[
2865... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sufentanil"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
"{u} (... | Palonosetron may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sufentanil (Compound)
Palonosetron (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) ... |
DB00845 | DB01166 | 1,490 | 477 | [
"DDInter406",
"DDInter379"
] | Clofazimine | Cilostazol | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1490,
24,
477
]
],
[
[
1490,
6,
8374
],
[
8374,
45,
477
]
],
[
[
1490,
7,
5202
],
[
5202,
46,
477
]
],
[
[
1490,
21,
28658
],
[
28658,... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Clofazimine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Clofazimine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Clofazimine (Compound) upregulates HP (Gene) and HP (Gene) is upregulated by Cilostazol (Compound)
Clofazimine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Cilostazol (Compound)
Clofazimine... |
DB09143 | DB11986 | 313 | 484 | [
"DDInter1701",
"DDInter648"
] | Sonidegib | Entrectinib | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
313,
24,
484
]
],
[
[
313,
63,
998
],
[
998,
24,
484
]
],
[
[
313,
24,
1320
],
[
1320,
24,
484
]
],
[
[
313,
24,
829
],
[
829,
6... | [
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Sonidegib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
[... | Sonidegib may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Sonidegib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and E... |
DB01144 | DB01276 | 1,326 | 123 | [
"DDInter540",
"DDInter706"
] | Diclofenamide | Exenatide | A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1326,
24,
123
]
],
[
[
1326,
24,
708
],
[
708,
63,
123
]
],
[
[
1326,
63,
1573
],
[
1573,
24,
123
]
],
[
[
1326,
24,
1220
],
[
1220,
... | [
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Diclofenamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
... | Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Prednisone... |
DB00450 | DB06589 | 78 | 1,250 | [
"DDInter603",
"DDInter1400"
] | Droperidol | Pazopanib | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
78,
25,
1250
]
],
[
[
78,
21,
28680
],
[
28680,
60,
1250
]
],
[
[
78,
23,
112
],
[
112,
23,
1250
]
],
[
[
78,
25,
1151
],
[
1151,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Droperidol",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Droperidol (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Pazopanib (Compound)
Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pazopanib
Droper... |
DB00317 | DB00582 | 883 | 1,622 | [
"DDInter810",
"DDInter1946"
] | Gefitinib | Voriconazole | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
883,
24,
1622
]
],
[
[
883,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
883,
21,
29232
],
[
29232,
60,
1622
]
],
[
[
883,
24,
752
],
[
752,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Gefitinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Gefitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Gefitinib (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Voriconazole (Compound)
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cim... |
DB00994 | DB09268 | 361 | 1,662 | [
"DDInter1277",
"DDInter1464"
] | Neomycin | Picosulfuric acid | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
361,
24,
1662
]
],
[
[
361,
62,
1252
],
[
1252,
23,
1662
]
],
[
[
361,
24,
1558
],
[
1558,
24,
1662
]
],
[
[
361,
63,
91
],
[
91,
... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Neomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Digoxin"
],
[
... | Neomycin may cause a minor interaction that can limit clinical effects when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Picosulfuric acid
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefoxitin and Cefoxitin may ... |
DB00331 | DB00865 | 1,645 | 939 | [
"DDInter1164",
"DDInter187"
] | Metformin | Benzphetamine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | A sympathomimetic agent with properties similar to dextroamphetamine. It is used in the treatment of obesity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1222) | Moderate | 1 | [
[
[
1645,
24,
939
]
],
[
[
1645,
24,
1529
],
[
1529,
1,
939
]
],
[
[
1645,
24,
401
],
[
401,
63,
939
]
],
[
[
1645,
63,
362
],
[
362,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine and Metamfetamine (Compound) resembles Benzphetamine (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction... |
DB00073 | DB14783 | 1,394 | 287 | [
"DDInter1608",
"DDInter574"
] | Rituximab | Diroximel fumarate | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1394,
24,
287
]
],
[
[
1394,
25,
1583
],
[
1583,
24,
287
]
],
[
[
1394,
24,
599
],
[
599,
24,
287
]
],
[
[
1394,
63,
1184
],
[
1184,
... | [
[
[
"Rituximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sarilumab"
],
[
"Saril... | Rituximab may lead to a major life threatening interaction when taken with Sarilumab and Sarilumab may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may ... |
DB00631 | DB11988 | 372 | 270 | [
"DDInter405",
"DDInter1321"
] | Clofarabine | Ocrelizumab | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
372,
24,
270
]
],
[
[
372,
63,
1461
],
[
1461,
23,
270
]
],
[
[
372,
63,
134
],
[
134,
24,
270
]
],
[
[
372,
24,
485
],
[
485,
2... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinore... |
DB00477 | DB00572 | 216 | 85 | [
"DDInter363",
"DDInter136"
] | Chlorpromazine | Atropine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
216,
24,
85
]
],
[
[
216,
63,
19
],
[
19,
24,
85
]
],
[
[
216,
25,
1166
],
[
1166,
40,
85
]
],
[
[
216,
24,
1133
],
[
1133,
40,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Chlorpromazine may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (C... |
DB00582 | DB01067 | 1,622 | 959 | [
"DDInter1946",
"DDInter826"
] | Voriconazole | Glipizide | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Major | 2 | [
[
[
1622,
25,
959
]
],
[
[
1622,
64,
245
],
[
245,
40,
959
]
],
[
[
1622,
25,
1411
],
[
1411,
1,
959
]
],
[
[
1622,
6,
8374
],
[
8374,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glipizide"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glimepiride"
],
[
"Glimepiride",
"... | Voriconazole may lead to a major life threatening interaction when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Voriconazole may lead to a major life threatening interaction when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
Voriconazole (Compound) ... |
DB00738 | DB11915 | 485 | 1,293 | [
"DDInter1420",
"DDInter1909"
] | Pentamidine | Valbenazine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
485,
24,
1293
]
],
[
[
485,
23,
112
],
[
112,
23,
1293
]
],
[
[
485,
63,
521
],
[
521,
24,
1293
]
],
[
[
485,
24,
401
],
[
401,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Valbenazine
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Go... |
DB00026 | DB15233 | 1,184 | 1,650 | [
"DDInter94",
"DDInter142"
] | Anakinra | Avapritinib | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
1184,
24,
1650
]
],
[
[
1184,
24,
1101
],
[
1101,
24,
1650
]
],
[
[
1184,
25,
908
],
[
908,
25,
1650
]
],
[
[
1184,
24,
4
],
[
4,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Anakinra may lead to a major life threatening interaction when taken with Golimumab and Golimumab may lead to a m... |
DB00312 | DB01285 | 1,023 | 708 | [
"DDInter1423",
"DDInter445"
] | Pentobarbital | Corticotropin | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1023,
24,
708
]
],
[
[
1023,
25,
126
],
[
126,
24,
708
]
],
[
[
1023,
1,
697
],
[
697,
24,
708
]
],
[
[
1023,
63,
1031
],
[
1031,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Pentobarbital",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"War... | Pentobarbital may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin
Pentobarbital (Compound) resembles Phenobarbital (Compound) and Phenobarbital may cause a moderate interaction that could exa... |
DB01255 | DB02546 | 633 | 137 | [
"DDInter1078",
"DDInter1947"
] | Lisdexamfetamine | Vorinostat | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Moderate | 1 | [
[
[
633,
24,
137
]
],
[
[
633,
40,
94
],
[
94,
1,
137
]
],
[
[
633,
21,
28709
],
[
28709,
60,
137
]
],
[
[
633,
63,
770
],
[
770,
25... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vorinostat"
]
],
[
[
"Lisdexamfetamine",
"{u} (Compound) resembles {v} (Compound)",
"Phenacemide"
],
[
"Phenacemide",
"{u} (Comp... | Lisdexamfetamine (Compound) resembles Phenacemide (Compound) and Phenacemide (Compound) resembles Vorinostat (Compound)
Lisdexamfetamine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Vorinostat (Compound)
Lisdexamfetamine may cause a moderate interaction that could... |
DB01182 | DB09082 | 371 | 659 | [
"DDInter1534",
"DDInter1934"
] | Propafenone | Vilanterol | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
371,
24,
659
]
],
[
[
371,
24,
927
],
[
927,
63,
659
]
],
[
[
371,
25,
1069
],
[
1069,
24,
659
]
],
[
[
371,
63,
485
],
[
485,
2... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[... | Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Propafenone may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may ca... |
DB00046 | DB06710 | 1,179 | 1,546 | [
"DDInter940",
"DDInter1193"
] | Insulin lispro | Methyltestosterone | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
1179,
24,
1546
]
],
[
[
1179,
24,
155
],
[
155,
1,
1546
]
],
[
[
1179,
24,
984
],
[
984,
40,
1546
]
],
[
[
1179,
24,
1486
],
[
1486,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymeste... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Methyltestosterone (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) resembles Me... |
DB00451 | DB00624 | 542 | 1,561 | [
"DDInter1064",
"DDInter1775"
] | Levothyroxine | Testosterone | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
542,
24,
1561
]
],
[
[
542,
24,
155
],
[
155,
1,
1561
]
],
[
[
542,
24,
1026
],
[
1026,
40,
1561
]
],
[
[
542,
6,
1829
],
[
1829,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Testosterone (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone (Compound) resembles Te... |
DB01592 | DB06210 | 1,596 | 72 | [
"DDInter975",
"DDInter631"
] | Iron | Eltrombopag | A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletio... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
1596,
24,
72
]
],
[
[
1596,
24,
1384
],
[
1384,
63,
72
]
],
[
[
1596,
63,
1283
],
[
1283,
24,
72
]
],
[
[
1596,
23,
1193
],
[
1193,
... | [
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Iron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
],
[
"Magald... | Iron may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate and Magaldrate may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Iron may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxide and Magnesium ox... |
DB00196 | DB00758 | 600 | 1,347 | [
"DDInter743",
"DDInter413"
] | Fluconazole | Clopidogrel | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Major | 2 | [
[
[
600,
25,
1347
]
],
[
[
600,
6,
10215
],
[
10215,
45,
1347
]
],
[
[
600,
7,
14690
],
[
14690,
46,
1347
]
],
[
[
600,
18,
3864
],
[
3864... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clopidogrel"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
"Cl... | Fluconazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Clopidogrel (Compound)
Fluconazole (Compound) upregulates ABHD6 (Gene) and ABHD6 (Gene) is upregulated by Clopidogrel (Compound)
Fluconazole (Compound) downregulates ARFIP2 (Gene) and ARFIP2 (Gene) is downregulated by Clopidogrel (Compound)
Fluc... |
DB00872 | DB12001 | 1,080 | 564 | [
"DDInter438",
"DDInter7"
] | Conivaptan | Abemaciclib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Major | 2 | [
[
[
1080,
25,
564
]
],
[
[
1080,
24,
868
],
[
868,
24,
564
]
],
[
[
1080,
25,
392
],
[
392,
24,
564
]
],
[
[
1080,
25,
982
],
[
982,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abemaciclib"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
"Vemurafe... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Conivaptan may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause... |
DB00813 | DB09241 | 704 | 1,629 | [
"DDInter722",
"DDInter1186"
] | Fentanyl | Methylene blue | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
704,
25,
1629
]
],
[
[
704,
24,
1311
],
[
1311,
24,
1629
]
],
[
[
704,
63,
73
],
[
73,
25,
1629
]
],
[
[
704,
1,
1048
],
[
1048,
... | [
[
[
"Fentanyl",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"Metocl... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Phentermine a... |
DB01285 | DB01324 | 708 | 178 | [
"DDInter445",
"DDInter1490"
] | Corticotropin | Polythiazide | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
708,
24,
178
]
],
[
[
708,
63,
674
],
[
674,
40,
178
]
],
[
[
708,
63,
126
],
[
126,
23,
178
]
],
[
[
708,
24,
52
],
[
52,
63,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor inter... |
DB08816 | DB12267 | 578 | 1,476 | [
"DDInter1802",
"DDInter233"
] | Ticagrelor | Brigatinib | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
578,
24,
1476
]
],
[
[
578,
23,
1135
],
[
1135,
23,
1476
]
],
[
[
578,
25,
230
],
[
230,
23,
1476
]
],
[
[
578,
63,
629
],
[
629,
... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Ticagrelor",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Ticagrelor may lead to a major life threatening interaction when taken with Relugolix and Relugolix may cause a minor ... |
DB01168 | DB09082 | 1,053 | 659 | [
"DDInter1526",
"DDInter1934"
] | Procarbazine | Vilanterol | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1053,
24,
659
]
],
[
[
1053,
64,
895
],
[
895,
24,
659
]
],
[
[
1053,
63,
88
],
[
88,
24,
659
]
],
[
[
1053,
25,
1663
],
[
1663,
... | [
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylphenidate"
],
[
"M... | Procarbazine may lead to a major life threatening interaction when taken with Methylphenidate and Methylphenidate may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metopro... |
DB01010 | DB01036 | 61 | 211 | [
"DDInter622",
"DDInter1832"
] | Edrophonium | Tolterodine | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Moderate | 1 | [
[
[
61,
24,
211
]
],
[
[
61,
63,
494
],
[
494,
40,
211
]
],
[
[
61,
21,
28900
],
[
28900,
60,
211
]
],
[
[
61,
63,
85
],
[
85,
24,
... | [
[
[
"Edrophonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
]
],
[
[
"Edrophonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
],
... | Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Tolterodine (Compound)
Edrophonium (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Tolterodine (Compound)
Edrophonium may cause a mo... |
DB00059 | DB08882 | 1,560 | 1,281 | [
"DDInter1404",
"DDInter1070"
] | Pegaspargase | Linagliptin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1560,
24,
1281
]
],
[
[
1560,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
1560,
24,
251
],
[
251,
24,
1281
]
],
[
[
1560,
63,
1685
],
[
1685,... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a moderate interaction... |
DB00773 | DB10989 | 896 | 496 | [
"DDInter702",
"DDInter858"
] | Etoposide | Hepatitis A Vaccine | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
896,
24,
496
]
],
[
[
896,
24,
4
],
[
4,
24,
496
]
],
[
[
896,
62,
147
],
[
147,
24,
496
]
],
[
[
896,
24,
738
],
[
738,
63,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucc... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Etoposide may cause a minor interaction that can limit clinical effects wh... |
DB09048 | DB14723 | 555 | 159 | [
"DDInter1284",
"DDInter1026"
] | Netupitant | Larotrectinib | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
555,
24,
159
]
],
[
[
555,
23,
466
],
[
466,
23,
159
]
],
[
[
555,
25,
1135
],
[
1135,
23,
159
]
],
[
[
555,
63,
63
],
[
63,
24,... | [
[
[
"Netupitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Netupitant",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
[... | Netupitant may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Netupitant may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause... |
DB00295 | DB04896 | 475 | 901 | [
"DDInter1244",
"DDInter1220"
] | Morphine | Milnacipran | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
475,
24,
901
]
],
[
[
475,
24,
41
],
[
41,
1,
901
]
],
[
[
475,
25,
1349
],
[
1349,
40,
901
]
],
[
[
475,
21,
28723
],
[
28723,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Morphine may lead to a major life threatening interaction when taken with Meperidine and Meperidine (Compound) resembles Milnacipran (Compound)
Morphin... |
DB00218 | DB06616 | 1,176 | 594 | [
"DDInter1247",
"DDInter224"
] | Moxifloxacin | Bosutinib | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Major | 2 | [
[
[
1176,
25,
594
]
],
[
[
1176,
21,
29231
],
[
29231,
60,
594
]
],
[
[
1176,
23,
112
],
[
112,
23,
594
]
],
[
[
1176,
24,
1559
],
[
1559,... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bosutinib"
]
],
[
[
"Moxifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Cardiac disorder"
],
[
"Cardiac disorder",
"{u} (Side Effect) is ca... | Moxifloxacin (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Bosutinib (Compound)
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when... |
DB00564 | DB01190 | 1,236 | 568 | [
"DDInter293",
"DDInter398"
] | Carbamazepine | Clindamycin | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Moderate | 1 | [
[
[
1236,
24,
568
]
],
[
[
1236,
6,
8374
],
[
8374,
45,
568
]
],
[
[
1236,
21,
29336
],
[
29336,
60,
568
]
],
[
[
1236,
25,
609
],
[
609,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clindamycin"
]
],
[
[
"Carbamazepine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Carbamazepine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Clindamycin (Compound)
Carbamazepine (Compound) causes Digestion impaired (Side Effect) and Digestion impaired (Side Effect) is caused by Clindamycin (Compound)
Carbamazepine may lead to a major life threatening interaction when taken with Clari... |
DB00041 | DB11943 | 1,648 | 255 | [
"DDInter38",
"DDInter495"
] | Aldesleukin | Delafloxacin | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Minor | 0 | [
[
[
1648,
23,
255
]
],
[
[
1648,
24,
1001
],
[
1001,
23,
255
]
],
[
[
1648,
25,
147
],
[
147,
23,
255
]
],
[
[
1648,
24,
1503
],
[
1503,
... | [
[
[
"Aldesleukin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Delafloxacin"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin
Aldesleukin may lead to a major life threatening interaction when taken with Vinblastine and Vinblast... |
DB00515 | DB04855 | 589 | 540 | [
"DDInter387",
"DDInter602"
] | Cisplatin | Dronedarone | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
589,
25,
540
]
],
[
[
589,
64,
228
],
[
228,
40,
540
]
],
[
[
589,
25,
33
],
[
33,
40,
540
]
],
[
[
589,
6,
4973
],
[
4973,
45,
... | [
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Cisplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dofetilide"
],
[
"Dofetilide",
"{u} (C... | Cisplatin may lead to a major life threatening interaction when taken with Dofetilide and Dofetilide (Compound) resembles Dronedarone (Compound)
Cisplatin may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Cisplatin (Compound) binds ABC... |
DB00564 | DB00704 | 1,236 | 267 | [
"DDInter293",
"DDInter1263"
] | Carbamazepine | Naltrexone | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1236,
24,
267
]
],
[
[
1236,
63,
475
],
[
475,
25,
267
]
],
[
[
1236,
6,
4973
],
[
4973,
45,
267
]
],
[
[
1236,
21,
28695
],
[
28695,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with Naltrexone
Carbamazepine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Naltrexone (Compound)
Carbamazepine (Compound) causes D... |
DB00619 | DB09128 | 1,419 | 1,241 | [
"DDInter909",
"DDInter231"
] | Imatinib | Brexpiprazole | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Major | 2 | [
[
[
1419,
25,
1241
]
],
[
[
1419,
24,
761
],
[
761,
24,
1241
]
],
[
[
1419,
25,
129
],
[
129,
24,
1241
]
],
[
[
1419,
63,
506
],
[
506,
... | [
[
[
"Imatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],
[
"Saxaglipti... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Imatinib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may c... |
DB00078 | DB06372 | 1,172 | 259 | [
"DDInter898",
"DDInter1594"
] | Ibritumomab tiuxetan | Rilonacept | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
1172,
24,
259
]
],
[
[
1172,
24,
1367
],
[
1367,
63,
259
]
],
[
[
1172,
25,
397
],
[
397,
63,
259
]
],
[
[
1172,
25,
1213
],
[
1213,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatit... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant) and Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Ibritumomab tiuxetan may lead to a major life threatenin... |
DB01064 | DB01246 | 1,148 | 820 | [
"DDInter987",
"DDInter45"
] | Isoprenaline | Alimemazine | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1148,
24,
820
]
],
[
[
1148,
24,
401
],
[
401,
24,
820
]
],
[
[
1148,
63,
939
],
[
939,
24,
820
]
],
[
[
1148,
63,
675
],
[
675,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamin... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.