drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00288 | DB01132 | 1,103 | 1,130 | [
"DDInter63",
"DDInter1472"
] | Amcinonide | Pioglitazone | Amcinonide is a corticosteroid. | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Minor | 0 | [
[
[
1103,
23,
1130
]
],
[
[
1103,
7,
2475
],
[
2475,
57,
1130
]
],
[
[
1103,
21,
28643
],
[
28643,
60,
1130
]
],
[
[
1103,
62,
1685
],
[
1... | [
[
[
"Amcinonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pioglitazone"
]
],
[
[
"Amcinonide",
"{u} (Compound) upregulates {v} (Gene)",
"RGS2"
],
[
"RGS2",
"{u} (Gene) is downregulated by {v} (C... | Amcinonide (Compound) upregulates RGS2 (Gene) and RGS2 (Gene) is downregulated by Pioglitazone (Compound)
Amcinonide (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Pioglitazone (Compound)
Amcinonide may cause a minor interaction that can limit clinical effects when taken with Insulin... |
DB00334 | DB08907 | 867 | 1,344 | [
"DDInter1326",
"DDInter280"
] | Olanzapine | Canagliflozin | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
867,
24,
1344
]
],
[
[
867,
24,
549
],
[
549,
1,
1344
]
],
[
[
867,
6,
4973
],
[
4973,
45,
1344
]
],
[
[
867,
24,
1148
],
[
1148,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Olanzapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Canagliflozin (Compound)
Olanzapine may cause a moderate interaction that could e... |
DB00502 | DB09268 | 1,300 | 1,662 | [
"DDInter853",
"DDInter1464"
] | Haloperidol | Picosulfuric acid | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1300,
24,
1662
]
],
[
[
1300,
25,
484
],
[
484,
63,
1662
]
],
[
[
1300,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
1300,
63,
73
],
[
73,
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
],
[
"... | Haloperidol may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Haloperidol may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause ... |
DB00327 | DB00902 | 421 | 104 | [
"DDInter890",
"DDInter1168"
] | Hydromorphone | Methdilazine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
421,
24,
104
]
],
[
[
421,
24,
13
],
[
13,
24,
104
]
],
[
[
421,
24,
820
],
[
820,
1,
104
]
],
[
[
421,
24,
537
],
[
537,
40,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Alime... |
DB01076 | DB01254 | 700 | 1,213 | [
"DDInter133",
"DDInter484"
] | Atorvastatin | Dasatinib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
700,
24,
1213
]
],
[
[
700,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
700,
7,
5077
],
[
5077,
46,
1213
]
],
[
[
700,
6,
8155
],
[
8155,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Atorvastatin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Atorvastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Atorvastatin (Compound) upregulates MVP (Gene) and MVP (Gene) is upregulated by Dasatinib (Compound)
Atorvastatin (Compound) binds ABCC5 (Gene) and ABCC5 (Gene) is upregulated by Dasatinib (Compound)
Atorvastatin (Compound) dow... |
DB00959 | DB01197 | 1,486 | 1,603 | [
"DDInter1191",
"DDInter292"
] | Methylprednisolone | Captopril | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
1486,
24,
1603
]
],
[
[
1486,
63,
610
],
[
610,
1,
1603
]
],
[
[
1486,
6,
4973
],
[
4973,
45,
1603
]
],
[
[
1486,
21,
30552
],
[
30552... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Methylprednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Captopril (Compound)
Methylprednisolone (Compound) causes Diabetic (Side Effe... |
DB00831 | DB09268 | 1,178 | 1,662 | [
"DDInter1866",
"DDInter1464"
] | Trifluoperazine | Picosulfuric acid | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1178,
24,
1662
]
],
[
[
1178,
24,
484
],
[
484,
63,
1662
]
],
[
[
1178,
25,
1618
],
[
1618,
24,
1662
]
],
[
[
1178,
63,
73
],
[
73,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectini... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Trifluoperazine may lead to a major life threatening interaction when taken with Cabozantinib and ... |
DB01149 | DB01410 | 851 | 423 | [
"DDInter1274",
"DDInter375"
] | Nefazodone | Ciclesonide | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Moderate | 1 | [
[
[
851,
24,
423
]
],
[
[
851,
63,
1573
],
[
1573,
1,
423
]
],
[
[
851,
63,
1351
],
[
1351,
40,
423
]
],
[
[
851,
64,
1486
],
[
1486,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Compou... |
DB00400 | DB12301 | 353 | 907 | [
"DDInter843",
"DDInter585"
] | Griseofulvin | Doravirine | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Moderate | 1 | [
[
[
353,
24,
907
]
],
[
[
353,
24,
1478
],
[
1478,
23,
907
]
],
[
[
353,
24,
159
],
[
159,
62,
907
]
],
[
[
353,
24,
978
],
[
978,
2... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doravirine"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Lar... |
DB00990 | DB04574 | 1,547 | 177 | [
"DDInter705",
"DDInter684"
] | Exemestane | Estrone sulfate (topical) | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Estrone 3-sulfate is a steroid sulfate that is the 3-sulfate of estrone. It has a role as a human metabolite and a mouse metabolite. It is a 17-oxo steroid and a steroid sulfate. It is functionally related to an estrone. It is a conjugate acid of an estrone 3-sulfate(1-). It derives from a hydride of an estrane. | Moderate | 1 | [
[
[
1547,
35,
177
]
],
[
[
1547,
63,
380
],
[
380,
1,
177
]
],
[
[
1547,
24,
35
],
[
35,
1,
177
]
],
[
[
1547,
1,
11385
],
[
11385,
... | [
[
[
"Exemestane",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone sulfate"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when ta... | Exemestane (Compound) resembles Estrone sulfate (Compound) and Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Estrone sulfate
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens (Compound) re... |
DB09046 | DB11718 | 1,094 | 927 | [
"DDInter1201",
"DDInter640"
] | Metreleptin | Encorafenib | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1094,
24,
927
]
],
[
[
1094,
63,
946
],
[
946,
24,
927
]
],
[
[
1094,
24,
484
],
[
484,
63,
927
]
],
[
[
1094,
23,
230
],
[
230,
... | [
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Metreleptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Buspirone"
],
[
... | Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Buspirone and Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entr... |
DB00867 | DB09078 | 1,052 | 1,228 | [
"DDInter1606",
"DDInter1036"
] | Ritodrine | Lenvatinib | Adrenergic beta-agonist used to control premature labor. | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
1052,
24,
1228
]
],
[
[
1052,
24,
609
],
[
609,
24,
1228
]
],
[
[
1052,
24,
927
],
[
927,
63,
1228
]
],
[
[
1052,
63,
1674
],
[
1674,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and... |
DB00532 | DB00736 | 208 | 660 | [
"DDInter1152",
"DDInter676"
] | Mephenytoin | Esomeprazole | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Minor | 0 | [
[
[
208,
23,
660
]
],
[
[
208,
62,
168
],
[
168,
23,
660
]
],
[
[
208,
24,
609
],
[
609,
62,
660
]
],
[
[
208,
24,
126
],
[
126,
24,... | [
[
[
"Mephenytoin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Esomeprazole"
]
],
[
[
"Mephenytoin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Mephenytoin may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Esomeprazole
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Cl... |
DB00341 | DB04948 | 1,242 | 1,084 | [
"DDInter343",
"DDInter1083"
] | Cetirizine | Lofexidine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
1242,
24,
1084
]
],
[
[
1242,
24,
1617
],
[
1617,
1,
1084
]
],
[
[
1242,
24,
1311
],
[
1311,
24,
1084
]
],
[
[
1242,
74,
701
],
[
701,... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apraclonidine"
],
[... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Apraclonidine and Apraclonidine (Compound) resembles Lofexidine (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interact... |
DB09074 | DB11986 | 1,362 | 484 | [
"DDInter1327",
"DDInter648"
] | Olaparib | Entrectinib | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1362,
24,
484
]
],
[
[
1362,
63,
1197
],
[
1197,
24,
484
]
],
[
[
1362,
24,
1320
],
[
1320,
24,
484
]
],
[
[
1362,
24,
180
],
[
180,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
],
[
... | Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Ela... |
DB00341 | DB00792 | 1,242 | 832 | [
"DDInter343",
"DDInter1878"
] | Cetirizine | Tripelennamine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat asthma; HAY fever; urticaria; and rhinitis; and also in veterinary applications. Tripelennamine is administered by various routes, including topically. | Moderate | 1 | [
[
[
1242,
24,
832
]
],
[
[
1242,
24,
100
],
[
100,
63,
832
]
],
[
[
1242,
24,
649
],
[
649,
1,
832
]
],
[
[
1242,
24,
1594
],
[
1594,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Clofeda... |
DB00507 | DB01215 | 316 | 1,418 | [
"DDInter1299",
"DDInter677"
] | Nitazoxanide | Estazolam | Nitazoxanide belongs to the class of drugs known as _thiazolides_. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses.... | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
316,
24,
1418
]
],
[
[
316,
24,
1216
],
[
1216,
40,
1418
]
],
[
[
316,
63,
905
],
[
905,
40,
1418
]
],
[
[
316,
24,
1382
],
[
1382,
... | [
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Nitazoxanide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[... | Nitazoxanide may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Nitazoxanide may cause a moderate interaction that could exacerbate diseases when taken with Lorazepam and Lorazepam (Compound) resembles Estazolam (Compound)
... |
DB00193 | DB00916 | 534 | 112 | [
"DDInter1841",
"DDInter1202"
] | Tramadol | Metronidazole | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
534,
23,
112
]
],
[
[
534,
6,
8374
],
[
8374,
45,
112
]
],
[
[
534,
21,
29028
],
[
29028,
60,
112
]
],
[
[
534,
63,
618
],
[
618,
... | [
[
[
"Tramadol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Tramadol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tramadol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Metronidazole (Compound)
Tramadol (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Metronidazole (Compound)
Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Abarelix ... |
DB00377 | DB08871 | 1,494 | 36 | [
"DDInter1382",
"DDInter666"
] | Palonosetron | Eribulin | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1494,
24,
36
]
],
[
[
1494,
23,
1247
],
[
1247,
23,
36
]
],
[
[
1494,
24,
519
],
[
519,
24,
36
]
],
[
[
1494,
25,
758
],
[
758,
... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Palonosetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Palonosetron may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Eribulin
Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Paliperidon... |
DB00978 | DB09481 | 739 | 460 | [
"DDInter1084",
"DDInter1113"
] | Lomefloxacin | Magnesium carbonate | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
739,
24,
460
]
],
[
[
739,
24,
401
],
[
401,
23,
460
]
],
[
[
739,
63,
355
],
[
355,
23,
460
]
],
[
[
739,
23,
60
],
[
60,
23,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Lactul... |
DB00263 | DB01124 | 1,029 | 1,411 | [
"DDInter1727",
"DDInter1828"
] | Sulfisoxazole | Tolbutamide | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
1029,
24,
1411
]
],
[
[
1029,
24,
959
],
[
959,
40,
1411
]
],
[
[
1029,
63,
245
],
[
245,
40,
1411
]
],
[
[
1029,
40,
11259
],
[
11259... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Sulfisoxazole may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Co... |
DB01182 | DB01611 | 371 | 1,487 | [
"DDInter1534",
"DDInter893"
] | Propafenone | Hydroxychloroquine | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
371,
25,
1487
]
],
[
[
371,
63,
1520
],
[
1520,
25,
1487
]
],
[
[
371,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
371,
21,
28658
],
[
2865... | [
[
[
"Propafenone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"... | Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Propafenone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Propafenone (Co... |
DB00350 | DB01174 | 1,214 | 697 | [
"DDInter1226",
"DDInter1442"
] | Minoxidil | Phenobarbital | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1214,
24,
697
]
],
[
[
1214,
24,
536
],
[
536,
40,
697
]
],
[
[
1214,
24,
401
],
[
401,
24,
697
]
],
[
[
1214,
24,
708
],
[
708,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
[... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenobarbital (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction t... |
DB01087 | DB04855 | 1,520 | 540 | [
"DDInter1520",
"DDInter602"
] | Primaquine | Dronedarone | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
1520,
25,
540
]
],
[
[
1520,
64,
347
],
[
347,
40,
540
]
],
[
[
1520,
25,
33
],
[
33,
40,
540
]
],
[
[
1520,
6,
8374
],
[
8374,
... | [
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Primaquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} (C... | Primaquine may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Primaquine may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone (Compound) resembles Dronedarone (Compound)
Primaquine (Compound) binds CY... |
DB00860 | DB08820 | 891 | 1,478 | [
"DDInter1513",
"DDInter997"
] | Prednisolone | Ivacaftor | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
891,
24,
1478
]
],
[
[
891,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
891,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
891,
62,
307
],
[
307,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Prednisolone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Prednisolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Prednisolone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modaf... |
DB00106 | DB00261 | 618 | 702 | [
"DDInter4",
"DDInter93"
] | Abarelix | Anagrelide | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Major | 2 | [
[
[
618,
25,
702
]
],
[
[
618,
23,
112
],
[
112,
62,
702
]
],
[
[
618,
24,
659
],
[
659,
63,
702
]
],
[
[
618,
25,
1300
],
[
1300,
6... | [
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anagrelide"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazole... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Anagrelide
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanter... |
DB08871 | DB13007 | 36 | 1,060 | [
"DDInter666",
"DDInter642"
] | Eribulin | Enfortumab vedotin | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
36,
24,
1060
]
],
[
[
36,
24,
129
],
[
129,
23,
1060
]
],
[
[
36,
64,
1593
],
[
1593,
24,
1060
]
],
[
[
36,
63,
1439
],
[
1439,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Enfortumab vedotin
Eribulin may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may ... |
DB00975 | DB06441 | 1,317 | 936 | [
"DDInter573",
"DDInter283"
] | Dipyridamole | Cangrelor | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Major | 2 | [
[
[
1317,
25,
936
]
],
[
[
1317,
23,
1631
],
[
1631,
62,
936
]
],
[
[
1317,
24,
97
],
[
97,
24,
936
]
],
[
[
1317,
63,
1171
],
[
1171,
... | [
[
[
"Dipyridamole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cangrelor"
]
],
[
[
"Dipyridamole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric",
... | Dipyridamole may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Cangrelor
Dipyridamole may cause a moderate interaction that could exacerbate diseases when taken with Oxaprozin and Oxaprozin ma... |
DB04948 | DB09038 | 1,084 | 1,450 | [
"DDInter1083",
"DDInter636"
] | Lofexidine | Empagliflozin | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1084,
24,
1450
]
],
[
[
1084,
63,
485
],
[
485,
24,
1450
]
],
[
[
1084,
24,
659
],
[
659,
63,
1450
]
],
[
[
1084,
24,
1491
],
[
1491,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
],
... | Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and V... |
DB00059 | DB12674 | 1,560 | 975 | [
"DDInter1404",
"DDInter1105"
] | Pegaspargase | Lurbinectedin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1560,
24,
975
]
],
[
[
1560,
24,
1613
],
[
1613,
24,
975
]
],
[
[
1560,
24,
159
],
[
159,
63,
975
]
],
[
[
1560,
63,
1257
],
[
1257,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when tak... |
DB00443 | DB00963 | 251 | 1,263 | [
"DDInter195",
"DDInter241"
] | Betamethasone | Bromfenac | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
251,
24,
1263
]
],
[
[
251,
24,
935
],
[
935,
40,
1263
]
],
[
[
251,
63,
831
],
[
831,
40,
1263
]
],
[
[
251,
24,
1512
],
[
1512,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Bromfenac (Co... |
DB09100 | DB09481 | 320 | 460 | [
"DDInter1799",
"DDInter1113"
] | Thyroid, porcine | Magnesium carbonate | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
320,
24,
460
]
],
[
[
320,
63,
245
],
[
245,
24,
460
]
],
[
[
320,
24,
428
],
[
428,
63,
460
]
],
[
[
320,
24,
286
],
[
286,
24,... | [
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Thyroid, porcine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimep... | Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium carbonate
Thyroid, porcine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB01069 | DB01309 | 401 | 1,254 | [
"DDInter1533",
"DDInter933"
] | Promethazine | Insulin glulisine | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
401,
24,
1254
]
],
[
[
401,
64,
1621
],
[
1621,
23,
1254
]
],
[
[
401,
63,
274
],
[
274,
23,
1254
]
],
[
[
401,
63,
1424
],
[
1424,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Promethazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Potassium chloride"
],
... | Promethazine may lead to a major life threatening interaction when taken with Potassium chloride and Potassium chloride may cause a minor interaction that can limit clinical effects when taken with Insulin glulisine
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Phentolamin... |
DB00231 | DB09154 | 1,174 | 1,475 | [
"DDInter1761",
"DDInter1686"
] | Temazepam | Sodium citrate | Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action [A175207, A175210, F3718, F3721]. Although the chem... | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Minor | 0 | [
[
[
1174,
23,
1475
]
],
[
[
1174,
1,
902
],
[
902,
23,
1475
]
],
[
[
1174,
40,
1382
],
[
1382,
23,
1475
]
],
[
[
1174,
23,
115
],
[
115,
... | [
[
[
"Temazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium citrate"
]
],
[
[
"Temazepam",
"{u} (Compound) resembles {v} (Compound)",
"Clobazam"
],
[
"Clobazam",
"{u} may cause a minor inter... | Temazepam (Compound) resembles Clobazam (Compound) and Clobazam may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Temazepam (Compound) resembles Midazolam (Compound) and Midazolam may cause a minor interaction that can limit clinical effects when taken with Sodium citrate
Tema... |
DB00087 | DB01033 | 599 | 328 | [
"DDInter41",
"DDInter1156"
] | Alemtuzumab | Mercaptopurine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
599,
24,
328
]
],
[
[
599,
24,
663
],
[
663,
23,
328
]
],
[
[
599,
63,
1257
],
[
1257,
24,
328
]
],
[
[
599,
24,
384
],
[
384,
6... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Pegfilgrastim... |
DB00601 | DB11817 | 453 | 1,259 | [
"DDInter1073",
"DDInter165"
] | Linezolid | Baricitinib | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
453,
25,
1259
]
],
[
[
453,
25,
407
],
[
407,
24,
1259
]
],
[
[
453,
64,
475
],
[
475,
24,
1259
]
],
[
[
453,
24,
1430
],
[
1430,
... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Opium"
],
[
"Opium",
"{u} may cause a ... | Linezolid may lead to a major life threatening interaction when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Linezolid may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that co... |
DB06754 | DB14276 | 707 | 1,631 | [
"DDInter471",
"DDInter1892"
] | Danaparoid | Turmeric | Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans. The active constituents are heparan, dermatan and, and they are isolated from the porcine intestinal mucosa [FDA Label]. Danaparoid possesses a potent antithrombic activity tha... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
707,
23,
1631
]
],
[
[
707,
64,
20
],
[
20,
23,
1631
]
],
[
[
707,
25,
1421
],
[
1421,
23,
1631
]
],
[
[
707,
64,
20
],
[
20,
24... | [
[
[
"Danaparoid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
]
],
[
[
"Danaparoid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
"Tenecteplase... | Danaparoid may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Danaparoid may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a minor interac... |
DB05294 | DB09054 | 1,069 | 384 | [
"DDInter1917",
"DDInter905"
] | Vandetanib | Idelalisib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1069,
24,
384
]
],
[
[
1069,
64,
318
],
[
318,
23,
384
]
],
[
[
1069,
63,
479
],
[
479,
23,
384
]
],
[
[
1069,
25,
1618
],
[
1618,
... | [
[
[
"Vandetanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escitalo... | Vandetanib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause ... |
DB00445 | DB11901 | 322 | 913 | [
"DDInter655",
"DDInter107"
] | Epirubicin | Apalutamide | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
322,
24,
913
]
],
[
[
322,
23,
112
],
[
112,
23,
913
]
],
[
[
322,
24,
110
],
[
110,
62,
913
]
],
[
[
322,
63,
600
],
[
600,
24,... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Epirubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Epirubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedoti... |
DB00472 | DB06810 | 758 | 397 | [
"DDInter758",
"DDInter1484"
] | Fluoxetine | Plicamycin | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Moderate | 1 | [
[
[
758,
24,
397
]
],
[
[
758,
24,
885
],
[
885,
24,
397
]
],
[
[
758,
63,
1061
],
[
1061,
24,
397
]
],
[
[
758,
24,
578
],
[
578,
6... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plicamycin"
]
],
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and ... |
DB08881 | DB09054 | 868 | 384 | [
"DDInter1925",
"DDInter905"
] | Vemurafenib | Idelalisib | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
868,
24,
384
]
],
[
[
868,
64,
318
],
[
318,
23,
384
]
],
[
[
868,
24,
1627
],
[
1627,
62,
384
]
],
[
[
868,
63,
307
],
[
307,
2... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escita... | Vemurafenib may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may ... |
DB04835 | DB09039 | 1,655 | 1,670 | [
"DDInter1125",
"DDInter629"
] | Maraviroc | Eliglustat | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
1655,
24,
1670
]
],
[
[
1655,
63,
322
],
[
322,
24,
1670
]
],
[
[
1655,
24,
478
],
[
478,
24,
1670
]
],
[
[
1655,
24,
124
],
[
124,
... | [
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[
... | Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib... |
DB00317 | DB00445 | 883 | 322 | [
"DDInter810",
"DDInter655"
] | Gefitinib | Epirubicin | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Moderate | 1 | [
[
[
883,
24,
322
]
],
[
[
883,
7,
8002
],
[
8002,
46,
322
]
],
[
[
883,
6,
10365
],
[
10365,
46,
322
]
],
[
[
883,
18,
6736
],
[
6736,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
]
],
[
[
"Gefitinib",
"{u} (Compound) upregulates {v} (Gene)",
"FBXL12"
],
[
"FBXL12",
"{u} (Gene) is upregulated by {v} (C... | Gefitinib (Compound) upregulates FBXL12 (Gene) and FBXL12 (Gene) is upregulated by Epirubicin (Compound)
Gefitinib (Compound) binds STK10 (Gene) and STK10 (Gene) is upregulated by Epirubicin (Compound)
Gefitinib (Compound) downregulates DRAP1 (Gene) and DRAP1 (Gene) is upregulated by Epirubicin (Compound)
Gefitinib (Co... |
DB00046 | DB06718 | 1,179 | 1,687 | [
"DDInter940",
"DDInter1709"
] | Insulin lispro | Stanozolol | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
1179,
24,
1687
]
],
[
[
1179,
24,
1197
],
[
1197,
1,
1687
]
],
[
[
1179,
24,
1561
],
[
1561,
40,
1687
]
],
[
[
1179,
24,
1573
],
[
157... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) resembles Stanozolol (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resembles St... |
DB00352 | DB00365 | 482 | 839 | [
"DDInter1814",
"DDInter842"
] | Tioguanine | Grepafloxacin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Minor | 0 | [
[
[
482,
23,
839
]
],
[
[
482,
24,
37
],
[
37,
62,
839
]
],
[
[
482,
63,
329
],
[
329,
23,
839
]
],
[
[
482,
35,
328
],
[
328,
62,
... | [
[
[
"Tioguanine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Grepafloxacin"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Bleomycin and Bleomyci... |
DB00902 | DB01242 | 104 | 1,237 | [
"DDInter1168",
"DDInter410"
] | Methdilazine | Clomipramine | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
104,
24,
1237
]
],
[
[
104,
75,
684
],
[
684,
1,
1237
]
],
[
[
104,
74,
1164
],
[
1164,
1,
1237
]
],
[
[
104,
1,
11320
],
[
11320,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Methdilazine",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",... | Methdilazine (Compound) resembles Thioridazine (Compound) and Methdilazine may lead to a major life threatening interaction when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Methdilazine (Compound) resembles Trimipramine (Compound) and Methdilazine may cause a moderate interacti... |
DB00196 | DB01165 | 600 | 1,539 | [
"DDInter743",
"DDInter1325"
] | Fluconazole | Ofloxacin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
600,
24,
1539
]
],
[
[
600,
25,
1176
],
[
1176,
1,
1539
]
],
[
[
600,
25,
945
],
[
945,
40,
1539
]
],
[
[
600,
24,
956
],
[
956,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Moxiflo... | Fluconazole may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Fluconazole may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Fluconazole may cause ... |
DB01039 | DB01050 | 535 | 848 | [
"DDInter718",
"DDInter900"
] | Fenofibrate | Ibuprofen | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
535,
24,
848
]
],
[
[
535,
6,
3486
],
[
3486,
45,
848
]
],
[
[
535,
21,
28652
],
[
28652,
60,
848
]
],
[
[
535,
40,
831
],
[
831,
... | [
[
[
"Fenofibrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Fenofibrate",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)"... | Fenofibrate (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Ibuprofen (Compound)
Fenofibrate (Compound) causes Colitis (Side Effect) and Colitis (Side Effect) is caused by Ibuprofen (Compound)
Fenofibrate (Compound) resembles Indomethacin (Compound) and Indomethacin may cause a moderate interaction that co... |
DB00991 | DB01088 | 97 | 714 | [
"DDInter1358",
"DDInter908"
] | Oxaprozin | Iloprost | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
97,
24,
714
]
],
[
[
97,
63,
1479
],
[
1479,
24,
714
]
],
[
[
97,
24,
1564
],
[
1564,
63,
714
]
],
[
[
97,
25,
840
],
[
840,
63,... | [
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Defib... |
DB01191 | DB14509 | 1,039 | 1,399 | [
"DDInter518",
"DDInter1081"
] | Dexfenfluramine | Lithium carbonate | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
1039,
25,
1399
]
],
[
[
1039,
63,
1479
],
[
1479,
23,
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]
],
[
[
1039,
24,
1385
],
[
1385,
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1399
]
],
[
[
1039,
64,
506
],
[
506... | [
[
[
"Dexfenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Dexfenfluramine may cause a moderate interaction that could exacerbate diseases wh... |
DB00014 | DB14881 | 521 | 180 | [
"DDInter839",
"DDInter1329"
] | Goserelin | Oliceridine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
521,
24,
180
]
],
[
[
521,
23,
112
],
[
112,
23,
180
]
],
[
[
521,
24,
401
],
[
401,
24,
180
]
],
[
[
521,
1,
774
],
[
774,
24,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Pro... |
DB00549 | DB01041 | 522 | 770 | [
"DDInter1955",
"DDInter1789"
] | Zafirlukast | Thalidomide | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
522,
24,
770
]
],
[
[
522,
6,
6365
],
[
6365,
45,
770
]
],
[
[
522,
21,
28784
],
[
28784,
60,
770
]
],
[
[
522,
24,
700
],
[
700,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound... | Zafirlukast (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Zafirlukast (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Thalidomide (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00694 | DB12267 | 51 | 1,476 | [
"DDInter485",
"DDInter233"
] | Daunorubicin | Brigatinib | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
51,
24,
1476
]
],
[
[
51,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
51,
63,
1184
],
[
1184,
24,
1476
]
],
[
[
51,
24,
918
],
[
918,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anak... |
DB00853 | DB11627 | 1,686 | 1,367 | [
"DDInter1762",
"DDInter860"
] | Temozolomide | Hepatitis B Vaccine (Recombinant) | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1686,
24,
1367
]
],
[
[
1686,
63,
1648
],
[
1648,
24,
1367
]
],
[
[
1686,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
1686,
24,
259
],
[
259... | [
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Temozolomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Temozolomide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Temozolomide may lead to a major life threatening interaction when taken with Cladrib... |
DB00963 | DB09075 | 1,263 | 498 | [
"DDInter241",
"DDInter621"
] | Bromfenac | Edoxaban | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
1263,
25,
498
]
],
[
[
1263,
24,
222
],
[
222,
24,
498
]
],
[
[
1263,
24,
738
],
[
738,
63,
498
]
],
[
[
1263,
63,
305
],
[
305,
... | [
[
[
"Bromfenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramine",... | Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib... |
DB06448 | DB06663 | 171 | 1,154 | [
"DDInter1087",
"DDInter1398"
] | Lonafarnib | Pasireotide | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
171,
25,
1154
]
],
[
[
171,
64,
966
],
[
966,
40,
1154
]
],
[
[
171,
63,
112
],
[
112,
23,
1154
]
],
[
[
171,
24,
466
],
[
466,
... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Octreotide"
],
[
"Octreotide",
"{u} ... | Lonafarnib may lead to a major life threatening interaction when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinic... |
DB00372 | DB06077 | 999 | 879 | [
"DDInter1793",
"DDInter1102"
] | Thiethylperazine | Lumateperone | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Moderate | 1 | [
[
[
999,
24,
879
]
],
[
[
999,
24,
1281
],
[
1281,
63,
879
]
],
[
[
999,
63,
1645
],
[
1645,
24,
879
]
],
[
[
999,
24,
1374
],
[
1374,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumateperone"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Metfo... |
DB09498 | DB13142 | 810 | 841 | [
"DDInter1715",
"DDInter274"
] | Strontium chloride Sr-89 | Calcium glubionate anhydrous | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
810,
24,
841
]
],
[
[
810,
63,
196
],
[
196,
23,
255
],
[
255,
24,
841
]
],
[
[
810,
63,
196
],
[
196,
25,
1292
],
[
1292,
24,
... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Altretamine and Altretamine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin and Delafloxacin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01404 | DB13928 | 757 | 1,385 | [
"DDInter820",
"DDInter1660"
] | Ginseng | Semaglutide | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
757,
24,
1385
]
],
[
[
757,
63,
1144
],
[
1144,
24,
1385
]
],
[
[
757,
24,
1296
],
[
1296,
24,
1385
]
],
[
[
757,
63,
1144
],
[
1144,
... | [
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Ginseng",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
],
[
... | Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Ginseng may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Ins... |
DB00158 | DB00794 | 356 | 759 | [
"DDInter771",
"DDInter1521"
] | Folic acid | Primidone | Folic acid, also known as folate or Vitamin B9, is a member of the B vitamin family and an essential cofactor for enzymes involved in DNA and RNA synthesis. More specifically, folic acid is required by the body for the synthesis of purines, pyrimidines, and methionine before incorporation into DNA or protein. Folic aci... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
356,
24,
759
]
],
[
[
356,
24,
697
],
[
697,
40,
759
]
],
[
[
356,
24,
362
],
[
362,
1,
759
]
],
[
[
356,
21,
28787
],
[
28787,
... | [
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Folic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
... | Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Folic acid may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound... |
DB08826 | DB09073 | 1,292 | 951 | [
"DDInter489",
"DDInter1379"
] | Deferiprone | Palbociclib | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
1292,
25,
951
]
],
[
[
1292,
64,
134
],
[
134,
24,
951
]
],
[
[
1292,
25,
283
],
[
283,
63,
951
]
],
[
[
1292,
24,
1017
],
[
1017,
... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vinorelbine"
],
[
"Vinorelbine",
"... | Deferiprone may lead to a major life threatening interaction when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Deferiprone may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate... |
DB05773 | DB06273 | 1,047 | 980 | [
"DDInter1848",
"DDInter1824"
] | Trastuzumab emtansine | Tocilizumab | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1047,
24,
980
]
],
[
[
1047,
63,
309
],
[
309,
24,
980
]
],
[
[
1047,
24,
110
],
[
110,
63,
980
]
],
[
[
1047,
25,
792
],
[
792,
... | [
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Trastuzumab emtansine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixab... | Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Trastuzumab emtansine may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00532 | DB06372 | 208 | 259 | [
"DDInter1152",
"DDInter1594"
] | Mephenytoin | Rilonacept | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
208,
24,
259
]
],
[
[
208,
24,
1573
],
[
1573,
24,
259
]
],
[
[
208,
24,
1093
],
[
1093,
63,
259
]
],
[
[
208,
63,
482
],
[
482,
... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab and Ixek... |
DB00357 | DB08820 | 1,051 | 1,478 | [
"DDInter71",
"DDInter997"
] | Aminoglutethimide | Ivacaftor | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1051,
24,
1478
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1051,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
1051,
24,
907
],
[
90... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v}... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Aminoglutethimide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Do... |
DB00731 | DB01105 | 1,144 | 222 | [
"DDInter1269",
"DDInter1665"
] | Nateglinide | Sibutramine | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1144,
24,
222
]
],
[
[
1144,
6,
8374
],
[
8374,
45,
222
]
],
[
[
1144,
21,
29152
],
[
29152,
60,
222
]
],
[
[
1144,
64,
839
],
[
839,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Nateglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Nateglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Nateglinide (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Sibutramine (Compound)
Nateglinide may lead to a major life threatening interaction when taken with Grepafloxacin and Grepafloxacin may... |
DB00813 | DB01254 | 704 | 1,213 | [
"DDInter722",
"DDInter484"
] | Fentanyl | Dasatinib | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
704,
25,
1213
]
],
[
[
704,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
704,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
704,
25,
1133
],
[
1133,... | [
[
[
"Fentanyl",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Fentanyl",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatinib"
... | Fentanyl (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Fentanyl (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Fentanyl may lead to a major life threatening interaction when taken with Granisetro... |
DB00277 | DB00468 | 1,031 | 1,424 | [
"DDInter1791",
"DDInter1557"
] | Theophylline | Quinine | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Moderate | 1 | [
[
[
1031,
24,
1424
]
],
[
[
1031,
6,
6017
],
[
6017,
45,
1424
]
],
[
[
1031,
21,
28709
],
[
28709,
60,
1424
]
],
[
[
1031,
63,
964
],
[
96... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
]
],
[
[
"Theophylline",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)"... | Theophylline (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Quinine (Compound)
Theophylline (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Quinine (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with D... |
DB00363 | DB01176 | 695 | 537 | [
"DDInter419",
"DDInter453"
] | Clozapine | Cyclizine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
695,
24,
537
]
],
[
[
695,
24,
1511
],
[
1511,
63,
537
]
],
[
[
695,
63,
1242
],
[
1242,
24,
537
]
],
[
[
695,
24,
104
],
[
104,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetiriz... |
DB00314 | DB00443 | 894 | 251 | [
"DDInter288",
"DDInter195"
] | Capreomycin | Betamethasone | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
894,
24,
251
]
],
[
[
894,
24,
870
],
[
870,
1,
251
]
],
[
[
894,
24,
1486
],
[
1486,
40,
251
]
],
[
[
894,
21,
29362
],
[
29362,
... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betamethasone (Compound)
Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compound) r... |
DB00222 | DB01039 | 245 | 535 | [
"DDInter825",
"DDInter718"
] | Glimepiride | Fenofibrate | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Moderate | 1 | [
[
[
245,
24,
535
]
],
[
[
245,
24,
831
],
[
831,
1,
535
]
],
[
[
245,
6,
6017
],
[
6017,
45,
535
]
],
[
[
245,
21,
28936
],
[
28936,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibrate"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indomethacin"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Fenofibrate (Compound)
Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Fenofibrate (Compound)
Glimepiride (Compound) causes Hyperhidrosis (Side Effect) ... |
DB00060 | DB00262 | 912 | 552 | [
"DDInter947",
"DDInter302"
] | Interferon beta-1a | Carmustine | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Moderate | 1 | [
[
[
912,
24,
552
]
],
[
[
912,
24,
1299
],
[
1299,
62,
552
]
],
[
[
912,
24,
1176
],
[
1176,
23,
552
]
],
[
[
912,
24,
713
],
[
713,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trovafloxac... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Trovafloxacin and Trovafloxacin may cause a minor interaction that can limit clinical effects when taken with Carmustine
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00845 | DB11978 | 1,490 | 124 | [
"DDInter406",
"DDInter822"
] | Clofazimine | Glasdegib | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
1490,
24,
124
]
],
[
[
1490,
23,
112
],
[
112,
23,
124
]
],
[
[
1490,
63,
79
],
[
79,
24,
124
]
],
[
[
1490,
24,
688
],
[
688,
2... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Clofazimine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Clofazimine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sora... |
DB00834 | DB09330 | 932 | 985 | [
"DDInter1215",
"DDInter1352"
] | Mifepristone | Osimertinib | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
932,
25,
985
]
],
[
[
932,
63,
168
],
[
168,
23,
985
]
],
[
[
932,
23,
112
],
[
112,
23,
985
]
],
[
[
932,
24,
1478
],
[
1478,
2... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Mifepristone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Borte... | Mifepristone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Mifepristone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Me... |
DB00480 | DB09228 | 1,668 | 687 | [
"DDInter1035",
"DDInter437"
] | Lenalidomide | Conestat alfa | Lenalidomide (previously referred to as CC-5013) is an immunomodulatory drug with potent antineoplastic, anti-angiogenic, and anti-inflammatory properties. It is a 4-amino-glutamyl analogue of [thalidomide] and like thalidomide, lenalidomide exists as a racemic mixture of the active S(-) and R(+) forms. However, lenali... | C1 Esterase Inhibitor (Recombinant) is a recombinant analogue of endogenous complement component-1 esterase inhibitor (rhC1INH), purified from the milk of transgenic rabbits. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways. It does this through inhibi... | Major | 2 | [
[
[
1668,
25,
687
]
],
[
[
1668,
25,
11
],
[
11,
24,
687
]
],
[
[
1668,
64,
1535
],
[
1535,
24,
687
]
],
[
[
1668,
25,
192
],
[
192,
... | [
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conestat alfa"
]
],
[
[
"Lenalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
],
[
"Toremifene",
... | Lenalidomide may lead to a major life threatening interaction when taken with Toremifene and Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Conestat alfa
Lenalidomide may lead to a major life threatening interaction when taken with Darbepoetin alfa and Darbepoetin alfa may ca... |
DB00307 | DB00992 | 1,101 | 842 | [
"DDInter202",
"DDInter1182"
] | Bexarotene | Methyl aminolevulinate (topical) | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
1101,
24,
842
]
],
[
[
1101,
21,
29124
],
[
29124,
60,
842
]
],
[
[
1101,
25,
1622
],
[
1622,
24,
842
]
],
[
[
1101,
24,
663
],
[
663,... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Bexarotene",
"{u} (Compound) causes {v} (Side Effect)",
"Rash pustular"
],
[
"Rash pustular",
"{u} (... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Bexarotene (Compound) causes Rash pustular (Side Effect) and Rash pustular (Side Effect) is caused by Methyl aminolevulinate (Compound)
Bexarotene may lead to a major life threatening interaction when taken... |
DB01172 | DB01357 | 416 | 890 | [
"DDInter1004",
"DDInter1160"
] | Kanamycin | Mestranol | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
416,
24,
890
]
],
[
[
416,
63,
1438
],
[
1438,
1,
890
]
],
[
[
416,
63,
50
],
[
50,
24,
890
]
],
[
[
416,
74,
1448
],
[
1448,
24... | [
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Kanamycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
[
... | Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Mestranol (Compound)
Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a moderate interaction that coul... |
DB00023 | DB01128 | 305 | 918 | [
"DDInter127",
"DDInter204"
] | Asparaginase Escherichia coli | Bicalutamide | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
305,
24,
918
]
],
[
[
305,
24,
1247
],
[
1247,
23,
918
]
],
[
[
305,
24,
786
],
[
786,
63,
918
]
],
[
[
305,
24,
473
],
[
473,
2... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Bicalutamide
Asparaginase Escherichia coli may cause a moderate interaction that could exacerb... |
DB09312 | DB10989 | 967 | 496 | [
"DDInter103",
"DDInter858"
] | Antilymphocyte immunoglobulin (horse) | Hepatitis A Vaccine | Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
967,
24,
496
]
],
[
[
967,
63,
4
],
[
4,
24,
496
]
],
[
[
967,
25,
976
],
[
976,
24,
496
]
],
[
[
967,
24,
270
],
[
270,
63,
... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a moderate interaction that could exacerbate di... | Antilymphocyte immunoglobulin (horse) may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Antilymphocyte immunoglobulin (horse) may lead... |
DB00705 | DB08912 | 441 | 1,040 | [
"DDInter496",
"DDInter462"
] | Delavirdine | Dabrafenib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
441,
24,
1040
]
],
[
[
441,
6,
3486
],
[
3486,
45,
1040
]
],
[
[
441,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
441,
63,
168
],
[
168,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Delavirdine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)... | Delavirdine (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Dabrafenib (Compound)
Delavirdine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Bortez... |
DB00285 | DB00945 | 1,100 | 1,479 | [
"DDInter1927",
"DDInter20"
] | Venlafaxine | Acetylsalicylic acid | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1100,
24,
1479
]
],
[
[
1100,
6,
10215
],
[
10215,
45,
1479
]
],
[
[
1100,
21,
29102
],
[
29102,
60,
1479
]
],
[
[
1100,
63,
1314
],
[
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Venlafaxine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v... | Venlafaxine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Acetylsalicylic acid (Compound)
Venlafaxine (Compound) causes Kidney function abnormal (Side Effect) and Kidney function abnormal (Side Effect) is caused by Acetylsalicylic acid (Compound)
Venlafaxine may cause a moderate interaction that could ... |
DB01045 | DB09074 | 463 | 1,362 | [
"DDInter1590",
"DDInter1327"
] | Rifampicin | Olaparib | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
463,
25,
1362
]
],
[
[
463,
25,
1478
],
[
1478,
24,
1362
]
],
[
[
463,
63,
79
],
[
79,
24,
1362
]
],
[
[
463,
64,
467
],
[
467,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
"{u} may c... | Rifampicin may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a mode... |
DB08880 | DB14443 | 1,510 | 987 | [
"DDInter1771",
"DDInter1931"
] | Teriflunomide | Vibrio cholerae CVD 103-HgR strain live antigen | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1510,
24,
987
]
],
[
[
1510,
25,
1480
],
[
1480,
24,
987
]
],
[
[
1510,
64,
141
],
[
141,
24,
987
]
],
[
[
1510,
25,
994
],
[
994,
... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Teriflunomide may lead to a major life threatening interaction when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Teriflunomide may lead to a major life threatening interaction when taken with Floxuridine ... |
DB00295 | DB00790 | 475 | 664 | [
"DDInter1244",
"DDInter1431"
] | Morphine | Perindopril | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Perindopril is a nonsulfhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration. Perindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible fo... | Moderate | 1 | [
[
[
475,
24,
664
]
],
[
[
475,
24,
1638
],
[
1638,
1,
664
]
],
[
[
475,
24,
954
],
[
954,
40,
664
]
],
[
[
475,
10,
11576
],
[
11576,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perindopril"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Perindopril (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Perindopril (Compound)
... |
DB00994 | DB01337 | 361 | 1,579 | [
"DDInter1277",
"DDInter1385"
] | Neomycin | Pancuronium | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | A bis-quaternary steroid that is a competitive nicotinic antagonist. As a neuromuscular blocking agent it is more potent than curare but has less effect on the circulatory system and on histamine release. | Major | 2 | [
[
[
361,
25,
1579
]
],
[
[
361,
64,
1610
],
[
1610,
1,
1579
]
],
[
[
361,
25,
728
],
[
728,
1,
1579
]
],
[
[
361,
21,
28746
],
[
28746,
... | [
[
[
"Neomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pancuronium"
]
],
[
[
"Neomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rocuronium"
],
[
"Rocuronium",
"{u} (Com... | Neomycin may lead to a major life threatening interaction when taken with Rocuronium and Rocuronium (Compound) resembles Pancuronium (Compound)
Neomycin may lead to a major life threatening interaction when taken with Vecuronium and Vecuronium (Compound) resembles Pancuronium (Compound)
Neomycin (Compound) causes Eryth... |
DB00774 | DB06691 | 1,577 | 849 | [
"DDInter889",
"DDInter1155"
] | Hydroflumethiazide | Mepyramine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1577,
24,
849
]
],
[
[
1577,
63,
1648
],
[
1648,
24,
849
]
],
[
[
1577,
24,
407
],
[
407,
63,
849
]
],
[
[
1577,
62,
262
],
[
262,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Opi... |
DB00317 | DB01036 | 883 | 211 | [
"DDInter810",
"DDInter1832"
] | Gefitinib | Tolterodine | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Minor | 0 | [
[
[
883,
23,
211
]
],
[
[
883,
24,
573
],
[
573,
40,
211
]
],
[
[
883,
63,
847
],
[
847,
40,
211
]
],
[
[
883,
6,
10215
],
[
10215,
... | [
[
[
"Gefitinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolterodine"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Fesoterodine and Fesoterodine (Compound) resembles Tolterodine (Compound)
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Tolterodine (Comp... |
DB00005 | DB00877 | 1,057 | 629 | [
"DDInter687",
"DDInter1678"
] | Etanercept | Sirolimus | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
1057,
25,
629
]
],
[
[
1057,
23,
1114
],
[
1114,
62,
629
]
],
[
[
1057,
23,
1461
],
[
1461,
23,
629
]
],
[
[
1057,
25,
1476
],
[
1476,... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Etanercept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sulfat... | Etanercept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Sirolimus
Etanercept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E ... |
DB01320 | DB09143 | 651 | 313 | [
"DDInter783",
"DDInter1701"
] | Fosphenytoin | Sonidegib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
651,
25,
313
]
],
[
[
651,
63,
1194
],
[
1194,
23,
313
]
],
[
[
651,
25,
478
],
[
478,
24,
313
]
],
[
[
651,
63,
597
],
[
597,
2... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ranitidine"
],
[
"Ranitid... | Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Ranitidine and Ranitidine may cause a minor interaction that can limit clinical effects when taken with Sonidegib
Fosphenytoin may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a... |
DB00564 | DB09122 | 1,236 | 1,613 | [
"DDInter293",
"DDInter1409"
] | Carbamazepine | Peginterferon beta-1a | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1236,
24,
1613
]
],
[
[
1236,
63,
600
],
[
600,
24,
1613
]
],
[
[
1236,
64,
168
],
[
168,
24,
1613
]
],
[
[
1236,
40,
362
],
[
362,
... | [
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Carbamazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazol... | Carbamazepine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Carbamazepine may lead to a major life threatening interaction when taken with Bortezomib and Bo... |
DB00586 | DB00612 | 1,512 | 1,121 | [
"DDInter537",
"DDInter216"
] | Diclofenac | Bisoprolol | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Moderate | 1 | [
[
[
1512,
24,
1121
]
],
[
[
1512,
24,
819
],
[
819,
40,
1121
]
],
[
[
1512,
63,
88
],
[
88,
40,
1121
]
],
[
[
1512,
6,
8374
],
[
8374,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Bisoprolol (Compound)
... |
DB10276 | DB12498 | 1,624 | 76 | [
"DDInter1623",
"DDInter1238"
] | Rotavirus vaccine | Mogamulizumab | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Major | 2 | [
[
[
1624,
25,
76
]
],
[
[
1624,
64,
1531
],
[
1531,
24,
76
]
],
[
[
1624,
25,
738
],
[
738,
24,
76
]
],
[
[
1624,
25,
676
],
[
676,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Canakinumab"
],
[
"Canakin... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Mogamulizumab
Rotavirus vaccine may lead to a major life threatening interaction when taken with Niraparib and Niraparib may caus... |
DB00999 | DB11126 | 504 | 900 | [
"DDInter883",
"DDInter276"
] | Hydrochlorothiazide | Calcium gluconate | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
504,
24,
900
]
],
[
[
504,
1,
674
],
[
674,
24,
900
]
],
[
[
504,
23,
1669
],
[
1669,
24,
900
]
],
[
[
504,
62,
1572
],
[
1572,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Hydrochlorothiazide",
"{u} (Compound) resembles {v} (Compound)",
"Trichlormethiazide"
],
[
"Trichlorme... | Hydrochlorothiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Hydrochlorothiazide may cause a minor interaction that can limit clinical effects when taken with Minocycline and Minocycline ma... |
DB06207 | DB11978 | 910 | 124 | [
"DDInter1667",
"DDInter822"
] | Silodosin | Glasdegib | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
910,
24,
124
]
],
[
[
910,
63,
475
],
[
475,
24,
124
]
],
[
[
910,
24,
98
],
[
98,
24,
124
]
],
[
[
910,
24,
159
],
[
159,
63,
... | [
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Silodosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
"... | Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib
Silodosin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may ca... |
DB00601 | DB01067 | 453 | 959 | [
"DDInter1073",
"DDInter826"
] | Linezolid | Glipizide | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
453,
24,
959
]
],
[
[
453,
63,
245
],
[
245,
40,
959
]
],
[
[
453,
24,
1411
],
[
1411,
1,
959
]
],
[
[
453,
21,
28987
],
[
28987,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB12364 | DB14357 | 1,421 | 944 | [
"DDInter200",
"DDInter347"
] | Betrixaban | Chamomile | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa. It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity. Betrixaban, now developed by Portola Pharmaceuticals In... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
1421,
23,
944
]
],
[
[
1421,
64,
256
],
[
256,
23,
944
]
],
[
[
1421,
64,
256
],
[
256,
64,
582
],
[
582,
23,
944
]
],
[
[
1421,
... | [
[
[
"Betrixaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Betrixaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prasugrel"
],
[
"Prasugrel",
... | Betrixaban may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile
Betrixaban may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may lead to a major life threate... |
DB00331 | DB09389 | 1,645 | 517 | [
"DDInter1164",
"DDInter1315"
] | Metformin | Norgestrel | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
1645,
24,
517
]
],
[
[
1645,
24,
1254
],
[
1254,
24,
517
]
],
[
[
1645,
63,
305
],
[
305,
24,
517
]
],
[
[
1645,
24,
1296
],
[
1296,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine and Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Asparagin... |
DB11793 | DB15091 | 738 | 676 | [
"DDInter1297",
"DDInter1901"
] | Niraparib | Upadacitinib | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
738,
25,
676
]
],
[
[
738,
63,
1430
],
[
1430,
24,
676
]
],
[
[
738,
24,
214
],
[
214,
24,
676
]
],
[
[
738,
63,
1184
],
[
1184,
... | [
[
[
"Niraparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Niraparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipuleuc... | Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and ... |
DB00357 | DB11979 | 1,051 | 1,320 | [
"DDInter71",
"DDInter625"
] | Aminoglutethimide | Elagolix | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
1051,
24,
1320
]
],
[
[
1051,
62,
168
],
[
168,
23,
1320
]
],
[
[
1051,
23,
271
],
[
271,
23,
1320
]
],
[
[
1051,
24,
1297
],
[
1297,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
]... | Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Aminoglutethimide may cause a minor interaction that can limit clinical effects when taken with Mirabegron and ... |
DB04844 | DB06699 | 843 | 774 | [
"DDInter1778",
"DDInter493"
] | Tetrabenazine | Degarelix | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
843,
24,
774
]
],
[
[
843,
63,
521
],
[
521,
1,
774
]
],
[
[
843,
21,
28722
],
[
28722,
60,
774
]
],
[
[
843,
62,
112
],
[
112,
... | [
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
... | Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Tetrabenazine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Degarelix (Compound)
Tetrabenazine may cause a minor interaction that... |
DB08826 | DB09074 | 1,292 | 1,362 | [
"DDInter489",
"DDInter1327"
] | Deferiprone | Olaparib | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
1292,
25,
1362
]
],
[
[
1292,
25,
725
],
[
725,
63,
1362
]
],
[
[
1292,
64,
896
],
[
896,
24,
1362
]
],
[
[
1292,
25,
250
],
[
250,
... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
],
[
"Satralizumab",
"{... | Deferiprone may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Deferiprone may lead to a major life threatening interaction when taken with Etoposide and Etoposide may cause a moderate in... |
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