drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00334 | DB00668 | 867 | 874 | [
"DDInter1326",
"DDInter652"
] | Olanzapine | Epinephrine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
867,
24,
874
]
],
[
[
867,
24,
688
],
[
688,
63,
874
]
],
[
[
867,
6,
7950
],
[
7950,
45,
874
]
],
[
[
867,
7,
4759
],
[
4759,
4... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Olanzapine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Epinephrine (Compound)
Olanzapine (Comp... |
DB06335 | DB09381 | 761 | 192 | [
"DDInter1646",
"DDInter678"
] | Saxagliptin | Esterified estrogens | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
761,
24,
192
]
],
[
[
761,
63,
752
],
[
752,
23,
192
]
],
[
[
761,
24,
1019
],
[
1019,
63,
192
]
],
[
[
761,
63,
1685
],
[
1685,
... | [
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Saxagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
... | Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort... |
DB00363 | DB00581 | 695 | 355 | [
"DDInter419",
"DDInter1018"
] | Clozapine | Lactulose | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
695,
24,
355
]
],
[
[
695,
63,
1647
],
[
1647,
1,
355
]
],
[
[
695,
24,
286
],
[
286,
62,
355
]
],
[
[
695,
25,
79
],
[
79,
24,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
"... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose (Compound) resembles Lactulose (Compound)
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction th... |
DB06822 | DB11095 | 802 | 235 | [
"DDInter1812",
"DDInter505"
] | Tinzaparin | Desirudin | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
802,
25,
235
]
],
[
[
802,
23,
297
],
[
297,
23,
235
]
],
[
[
802,
63,
1100
],
[
1100,
24,
235
]
],
[
[
802,
24,
1004
],
[
1004,
... | [
[
[
"Tinzaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Tinzaparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u}... | Tinzaparin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Tinzaparin may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may caus... |
DB00382 | DB00981 | 62 | 1,528 | [
"DDInter1734",
"DDInter1462"
] | Tacrine | Physostigmine | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
62,
24,
1528
]
],
[
[
62,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
62,
24,
543
],
[
543,
24,
1528
]
],
[
[
62,
63,
701
],
[
701,
24... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperam... |
DB00900 | DB01254 | 45 | 1,213 | [
"DDInter544",
"DDInter484"
] | Didanosine | Dasatinib | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. Didanosine is a potent inhibitor of HIV replication, acting as a chain-termi... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
45,
24,
1213
]
],
[
[
45,
7,
3218
],
[
3218,
46,
1213
]
],
[
[
45,
6,
4071
],
[
4071,
57,
1213
]
],
[
[
45,
21,
28882
],
[
28882,
... | [
[
[
"Didanosine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Didanosine",
"{u} (Compound) upregulates {v} (Gene)",
"IKBKE"
],
[
"IKBKE",
"{u} (Gene) is upregulated by {v} (Co... | Didanosine (Compound) upregulates IKBKE (Gene) and IKBKE (Gene) is upregulated by Dasatinib (Compound)
Didanosine (Compound) binds PNP (Gene) and PNP (Gene) is downregulated by Dasatinib (Compound)
Didanosine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caus... |
DB00959 | DB01050 | 1,486 | 848 | [
"DDInter1191",
"DDInter900"
] | Methylprednisolone | Ibuprofen | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
1486,
24,
848
]
],
[
[
1486,
6,
4973
],
[
4973,
45,
848
]
],
[
[
1486,
10,
11666
],
[
11666,
49,
848
]
],
[
[
1486,
21,
28841
],
[
288... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v}... | Methylprednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ibuprofen (Compound)
Methylprednisolone (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Ibuprofen (Compound)
Methylprednisolone (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Eff... |
DB00398 | DB00418 | 79 | 536 | [
"DDInter1702",
"DDInter1650"
] | Sorafenib | Secobarbital | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Moderate | 1 | [
[
[
79,
24,
536
]
],
[
[
79,
63,
1023
],
[
1023,
1,
536
]
],
[
[
79,
24,
697
],
[
697,
1,
536
]
],
[
[
79,
6,
3486
],
[
3486,
45,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],
[... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Secobarbital (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Secobarbit... |
DB00305 | DB00970 | 377 | 0 | [
"DDInter1232",
"DDInter466"
] | Mitomycin | Dactinomycin | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Moderate | 1 | [
[
[
377,
24,
0
]
],
[
[
377,
6,
4973
],
[
4973,
45,
0
]
],
[
[
377,
7,
17884
],
[
17884,
46,
0
]
],
[
[
377,
18,
2183
],
[
2183,
57,... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dactinomycin"
]
],
[
[
"Mitomycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Mitomycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dactinomycin (Compound)
Mitomycin (Compound) upregulates ZDHHC11 (Gene) and ZDHHC11 (Gene) is upregulated by Dactinomycin (Compound)
Mitomycin (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Dactinomycin (Compound)
Mitomycin... |
DB00962 | DB12130 | 1,639 | 1,017 | [
"DDInter1957",
"DDInter1094"
] | Zaleplon | Lorlatinib | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1639,
24,
1017
]
],
[
[
1639,
62,
1101
],
[
1101,
23,
1017
]
],
[
[
1639,
63,
629
],
[
629,
24,
1017
]
],
[
[
1639,
24,
214
],
[
214,
... | [
[
[
"Zaleplon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Zaleplon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
[
"B... | Zaleplon may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may c... |
DB08912 | DB11575 | 1,040 | 1,676 | [
"DDInter462",
"DDInter841"
] | Dabrafenib | Grazoprevir | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common i... | Major | 2 | [
[
[
1040,
25,
1676
]
],
[
[
1040,
63,
723
],
[
723,
24,
1676
]
],
[
[
1040,
24,
351
],
[
351,
63,
1676
]
],
[
[
1040,
25,
927
],
[
927,
... | [
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Grazoprevir"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
"Aprepitan... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Grazoprevir
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboc... |
DB01159 | DB09074 | 419 | 1,362 | [
"DDInter854",
"DDInter1327"
] | Halothane | Olaparib | A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
419,
24,
1362
]
],
[
[
419,
24,
1478
],
[
1478,
24,
1362
]
],
[
[
419,
63,
79
],
[
79,
24,
1362
]
],
[
[
419,
24,
1619
],
[
1619,
... | [
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Halothane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
"... | Halothane may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Halothane may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may... |
DB00705 | DB08938 | 441 | 1,384 | [
"DDInter496",
"DDInter1112"
] | Delavirdine | Magaldrate | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
441,
24,
1384
]
],
[
[
441,
24,
167
],
[
167,
23,
1384
]
],
[
[
441,
25,
263
],
[
263,
23,
1384
]
],
[
[
441,
63,
1573
],
[
1573,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Delavirdine may lead to a major life threatening interaction when taken with Axitinib and Axitinib may ca... |
DB00615 | DB08895 | 690 | 976 | [
"DDInter1589",
"DDInter1825"
] | Rifabutin | Tofacitinib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Tofacitinib is an inhibitor of Janus kinases, a group of intracellular enzymes involved in signalling pathways that affect hematopoiesis and immune cell function. It is approved by the FDA for treatment of moderate to severe rheumatoid arthritis that responds inadequately to methotrexate or in those who are intolerant ... | Moderate | 1 | [
[
[
690,
24,
976
]
],
[
[
690,
24,
214
],
[
214,
63,
976
]
],
[
[
690,
25,
1017
],
[
1017,
63,
976
]
],
[
[
690,
23,
86
],
[
86,
24,... | [
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib
Rifabutin may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cau... |
DB08931 | DB09112 | 947 | 1,455 | [
"DDInter1600",
"DDInter1306"
] | Riociguat | Nitrous acid | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
947,
24,
1455
]
],
[
[
947,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
947,
63,
1574
],
[
1574,
24,
1455
]
],
[
[
947,
24,
433
],
[
433,
... | [
[
[
"Riociguat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Riociguat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
[... | Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Urea and Urea m... |
DB00214 | DB09112 | 1,028 | 1,455 | [
"DDInter1836",
"DDInter1306"
] | Torasemide | Nitrous acid | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
1028,
24,
1455
]
],
[
[
1028,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
1028,
24,
433
],
[
433,
63,
1455
]
],
[
[
1028,
24,
1450
],
[
1450... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin... |
DB00040 | DB00373 | 27 | 461 | [
"DDInter827",
"DDInter1809"
] | Glucagon | Timolol | Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and... | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Minor | 0 | [
[
[
27,
23,
461
]
],
[
[
27,
23,
729
],
[
729,
40,
461
]
],
[
[
27,
23,
126
],
[
126,
62,
461
]
],
[
[
27,
23,
729
],
[
729,
1,
... | [
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Timolol"
]
],
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Penbutolol"
],
[
"Penbut... | Glucagon may cause a minor interaction that can limit clinical effects when taken with Penbutolol and Penbutolol (Compound) resembles Timolol (Compound)
Glucagon may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effe... |
DB00366 | DB11130 | 1,594 | 407 | [
"DDInter600",
"DDInter1344"
] | Doxylamine | Opium | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1594,
24,
407
]
],
[
[
1594,
24,
558
],
[
558,
24,
407
]
],
[
[
1594,
63,
556
],
[
556,
24,
407
]
],
[
[
1594,
24,
418
],
[
418,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
],
[
"Zo... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Zolpidem and Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Opium
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Valproic acid and Valproic aci... |
DB00831 | DB11113 | 1,178 | 657 | [
"DDInter1866",
"DDInter307"
] | Trifluoperazine | Castor oil | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
1178,
24,
657
]
],
[
[
1178,
24,
927
],
[
927,
63,
657
]
],
[
[
1178,
24,
1491
],
[
1491,
24,
657
]
],
[
[
1178,
25,
985
],
[
985,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Midostaur... |
DB01105 | DB01276 | 222 | 123 | [
"DDInter1665",
"DDInter706"
] | Sibutramine | Exenatide | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
222,
24,
123
]
],
[
[
222,
63,
532
],
[
532,
24,
123
]
],
[
[
222,
23,
984
],
[
984,
63,
123
]
],
[
[
222,
25,
1039
],
[
1039,
2... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Sibutramine may cause a minor interaction that can limit clinical effects when taken with Danazol and Danazol ma... |
DB00290 | DB14783 | 329 | 287 | [
"DDInter219",
"DDInter574"
] | Bleomycin | Diroximel fumarate | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
329,
24,
287
]
],
[
[
329,
24,
995
],
[
995,
24,
287
]
],
[
[
329,
63,
599
],
[
599,
24,
287
]
],
[
[
329,
25,
850
],
[
850,
24,... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
],
... | Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyurea and Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab a... |
DB00078 | DB00861 | 1,172 | 914 | [
"DDInter898",
"DDInter551"
] | Ibritumomab tiuxetan | Diflunisal | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Major | 2 | [
[
[
1172,
25,
914
]
],
[
[
1172,
25,
1564
],
[
1564,
63,
914
]
],
[
[
1172,
25,
1061
],
[
1061,
24,
914
]
],
[
[
1172,
64,
366
],
[
366,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diflunisal"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
],
[
"Defi... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Defibrotide and Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Treprostinil and Treprostinil... |
DB00005 | DB09054 | 1,057 | 384 | [
"DDInter687",
"DDInter905"
] | Etanercept | Idelalisib | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1057,
25,
384
]
],
[
[
1057,
25,
725
],
[
725,
63,
384
]
],
[
[
1057,
25,
328
],
[
328,
24,
384
]
],
[
[
1057,
24,
289
],
[
289,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Satralizumab"
],
[
"Satralizumab",
"{... | Etanercept may lead to a major life threatening interaction when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Etanercept may lead to a major life threatening interaction when taken with Mercaptopurine and Mercaptopurine may cause a m... |
DB01076 | DB14724 | 700 | 48 | [
"DDInter133",
"DDInter634"
] | Atorvastatin | Emapalumab | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
700,
24,
48
]
],
[
[
700,
62,
126
],
[
126,
24,
48
]
],
[
[
700,
63,
467
],
[
467,
24,
48
]
],
[
[
700,
62,
126
],
[
126,
63,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Atorvastatin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
],
[
... | Atorvastatin may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvast... |
DB00661 | DB13142 | 122 | 841 | [
"DDInter1928",
"DDInter274"
] | Verapamil | Calcium glubionate anhydrous | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Calcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. | Moderate | 1 | [
[
[
122,
24,
841
]
],
[
[
122,
24,
1053
],
[
1053,
23,
255
],
[
255,
24,
841
]
],
[
[
122,
24,
1053
],
[
1053,
24,
762
],
[
762,
24,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium glubionate anhydrous"
]
],
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazin... | Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine may cause a minor interaction that can limit clinical effects when taken with Delafloxacin and Delafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Calcium glub... |
DB00713 | DB09293 | 1,138 | 116 | [
"DDInter1354",
"DDInter954"
] | Oxacillin | Iodide I-131 | An antibiotic similar to [flucloxacillin] used in resistant staphylococci infections. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
1138,
24,
116
]
],
[
[
1138,
1,
1249
],
[
1249,
24,
116
]
],
[
[
1138,
63,
126
],
[
126,
24,
116
]
],
[
[
1138,
40,
950
],
[
950,
... | [
[
[
"Oxacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Oxacillin",
"{u} (Compound) resembles {v} (Compound)",
"Nafcillin"
],
[
"Nafcillin",
"{u} may cause a moderate ... | Oxacillin (Compound) resembles Nafcillin (Compound) and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Oxacillin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exace... |
DB00319 | DB00759 | 790 | 1,620 | [
"DDInter1474",
"DDInter1783"
] | Piperacillin | Tetracycline | Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Moderate | 1 | [
[
[
790,
24,
1620
]
],
[
[
790,
24,
1572
],
[
1572,
40,
1620
]
],
[
[
790,
63,
964
],
[
964,
40,
1620
]
],
[
[
790,
6,
10612
],
[
10612,
... | [
[
[
"Piperacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]
],
[
[
"Piperacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
]... | Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Piperacillin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Tetrac... |
DB01024 | DB12615 | 1,096 | 1,381 | [
"DDInter1252",
"DDInter1482"
] | Mycophenolic acid | Plazomicin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Developed by Achaogen biopharmaceuticals, plazomicin is a next-generation aminoglycoside synthetically derived from . The structure of plazomicin was established via appending hydroxylaminobutyric acid to at position 1 and 2-hydroxyethyl group at position 6' . It was designed to evade all clinically relevant aminoglyco... | Moderate | 1 | [
[
[
1096,
24,
1381
]
],
[
[
1096,
24,
416
],
[
416,
24,
1381
]
],
[
[
1096,
63,
361
],
[
361,
24,
1381
]
],
[
[
1096,
62,
387
],
[
387,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plazomicin"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Kanamycin and Kanamycin may cause a moderate interaction that could exacerbate diseases when taken with Plazomicin
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Neomycin ... |
DB00365 | DB00970 | 839 | 0 | [
"DDInter842",
"DDInter466"
] | Grepafloxacin | Dactinomycin | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Minor | 0 | [
[
[
839,
23,
0
]
],
[
[
839,
24,
384
],
[
384,
63,
0
]
],
[
[
839,
23,
611
],
[
611,
24,
0
]
],
[
[
839,
62,
377
],
[
377,
24,
... | [
[
[
"Grepafloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dactinomycin"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Dactinomycin
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Dacarbazine and... |
DB08865 | DB11989 | 1,593 | 1,434 | [
"DDInter448",
"DDInter183"
] | Crizotinib | Benznidazole | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Benznidazole was granted accelerated approval for the treatment of Chagas disease in children 2-12 years of age by the FDA on August 29, 2017. It is the first treatment made available in the United States for Chagas disease. | Moderate | 1 | [
[
[
1593,
24,
1434
]
],
[
[
1593,
63,
788
],
[
788,
24,
1434
]
],
[
[
1593,
24,
375
],
[
375,
24,
1434
]
],
[
[
1593,
24,
148
],
[
148,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benznidazole"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
],
... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Benznidazole
Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pe... |
DB00978 | DB12141 | 739 | 971 | [
"DDInter1084",
"DDInter817"
] | Lomefloxacin | Gilteritinib | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
739,
24,
971
]
],
[
[
739,
62,
112
],
[
112,
23,
971
]
],
[
[
739,
63,
485
],
[
485,
24,
971
]
],
[
[
739,
24,
823
],
[
823,
63,... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine a... |
DB00373 | DB00743 | 461 | 808 | [
"DDInter1809",
"DDInter792"
] | Timolol | Gadobenic acid | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Gadobenic acid, usually available in the salt form gadobenate dimeglumine, is a linear MRI gadolinium-based contrast agent (GBCA) used primarily for MR imaging of the liver. It differs from other GBCAs due to the benzene ring that confers weak protein binding, thus leading to an increased R1 and R2 relaxivity. As gadob... | Moderate | 1 | [
[
[
461,
24,
808
]
],
[
[
461,
24,
1431
],
[
1431,
1,
808
]
],
[
[
461,
63,
457
],
[
457,
40,
808
]
],
[
[
461,
21,
28769
],
[
28769,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadobenic acid"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadopentetic acid"
],
... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Gadopentetic acid and Gadopentetic acid (Compound) resembles Gadobenic acid (Compound)
Timolol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide and Gadodiamide (Compound) resembles Gadobeni... |
DB01254 | DB12130 | 1,213 | 1,017 | [
"DDInter484",
"DDInter1094"
] | Dasatinib | Lorlatinib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1213,
24,
1017
]
],
[
[
1213,
63,
608
],
[
608,
23,
1017
]
],
[
[
1213,
24,
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],
[
1612,
23,
1017
]
],
[
[
1213,
23,
271
],
[
271,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir... |
DB00549 | DB08889 | 522 | 350 | [
"DDInter1955",
"DDInter299"
] | Zafirlukast | Carfilzomib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
522,
24,
350
]
],
[
[
522,
21,
28762
],
[
28762,
60,
350
]
],
[
[
522,
24,
1060
],
[
1060,
63,
350
]
],
[
[
522,
63,
482
],
[
482,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Zafirlukast",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cau... | Zafirlukast (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and Enfortumab vedotin may cause a moderate interaction that could exacerbate diseases when t... |
DB01229 | DB05812 | 973 | 1,374 | [
"DDInter1378",
"DDInter8"
] | Paclitaxel (protein-bound) | Abiraterone | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
973,
24,
1374
]
],
[
[
973,
6,
10417
],
[
10417,
45,
1374
]
],
[
[
973,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
973,
25,
74
],
[
74,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Paclitaxel",
"{u} (Compound) binds {v} (Gene)",
"ABCC1"
],
[
"ABCC1",
"{u} (Gene) is bound by {v} (Compound)",
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone
Paclitaxel (Compound) binds ABCC1 (Gene) and ABCC1 (Gene) is bound by Abiraterone (Compound)
Paclitaxel (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
P... |
DB00820 | DB08912 | 402 | 1,040 | [
"DDInter1736",
"DDInter462"
] | Tadalafil | Dabrafenib | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
402,
24,
1040
]
],
[
[
402,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
402,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
402,
63,
1101
],
[
1101,... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Tadalafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tadalafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Tadalafil (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene a... |
DB00015 | DB00814 | 582 | 1,171 | [
"DDInter1585",
"DDInter1143"
] | Reteplase | Meloxicam | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Moderate | 1 | [
[
[
582,
24,
1171
]
],
[
[
582,
24,
1027
],
[
1027,
40,
1171
]
],
[
[
582,
25,
936
],
[
936,
63,
1171
]
],
[
[
582,
24,
477
],
[
477,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Piroxicam"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Reteplase may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may cause a moderate interaction that could exacerbate diseases w... |
DB01075 | DB01170 | 1,376 | 1,150 | [
"DDInter569",
"DDInter846"
] | Diphenhydramine | Guanethidine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem] | Moderate | 1 | [
[
[
1376,
24,
1150
]
],
[
[
1376,
63,
475
],
[
475,
24,
1150
]
],
[
[
1376,
24,
849
],
[
849,
63,
1150
]
],
[
[
1376,
35,
1264
],
[
1264,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guanethidine"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
]... | Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Guanethidine
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine an... |
DB00582 | DB00950 | 1,622 | 1,413 | [
"DDInter1946",
"DDInter732"
] | Voriconazole | Fexofenadine | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Minor | 0 | [
[
[
1622,
23,
1413
]
],
[
[
1622,
25,
543
],
[
543,
1,
1413
]
],
[
[
1622,
21,
28741
],
[
28741,
60,
1413
]
],
[
[
1622,
24,
86
],
[
86,
... | [
[
[
"Voriconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fexofenadine"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Loperamide"
],
[
"Lopera... | Voriconazole may lead to a major life threatening interaction when taken with Loperamide and Loperamide (Compound) resembles Fexofenadine (Compound)
Voriconazole (Compound) causes Agitation (Side Effect) and Agitation (Side Effect) is caused by Fexofenadine (Compound)
Voriconazole may cause a moderate interaction that ... |
DB00421 | DB12332 | 443 | 1,619 | [
"DDInter1707",
"DDInter1626"
] | Spironolactone | Rucaparib | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
443,
24,
1619
]
],
[
[
443,
24,
222
],
[
222,
23,
1619
]
],
[
[
443,
23,
1135
],
[
1135,
23,
1619
]
],
[
[
443,
24,
1662
],
[
1662,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Na... |
DB00444 | DB00526 | 63 | 1,555 | [
"DDInter1765",
"DDInter1355"
] | Teniposide | Oxaliplatin | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
63,
24,
1555
]
],
[
[
63,
6,
17404
],
[
17404,
45,
1555
]
],
[
[
63,
24,
810
],
[
810,
63,
1555
]
],
[
[
63,
63,
289
],
[
289,
2... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Teniposide",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Teniposide (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Oxaliplatin (Compound)
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Ox... |
DB06603 | DB09280 | 39 | 1,604 | [
"DDInter1387",
"DDInter1101"
] | Panobinostat | Lumacaftor | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
39,
25,
1604
]
],
[
[
39,
64,
1171
],
[
1171,
24,
1604
]
],
[
[
39,
25,
292
],
[
292,
24,
1604
]
],
[
[
39,
63,
522
],
[
522,
24... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meloxicam"
],
[
"Meloxicam",
"{u}... | Panobinostat may lead to a major life threatening interaction when taken with Meloxicam and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Panobinostat may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib may cause a moderate ... |
DB00477 | DB01114 | 216 | 272 | [
"DDInter363",
"DDInter362"
] | Chlorpromazine | Chlorpheniramine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
216,
35,
272
]
],
[
[
216,
1,
11775
],
[
11775,
40,
272
]
],
[
[
216,
1,
1237
],
[
1237,
63,
272
]
],
[
[
216,
1,
11275
],
[
11275,
... | [
[
[
"Chlorpromazine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) resembles {v} (Compound)",
"Chloropyramine"
... | Chlorpromazine (Compound) resembles Chlorpheniramine (Compound) and
Chlorpromazine (Compound) resembles Chloropyramine (Compound) and Chloropyramine (Compound) resembles Chlorpheniramine (Compound)
Chlorpromazine (Compound) resembles Clomipramine (Compound) and Clomipramine may cause a moderate interaction that could e... |
DB00334 | DB00572 | 867 | 85 | [
"DDInter1326",
"DDInter136"
] | Olanzapine | Atropine | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
867,
24,
85
]
],
[
[
867,
24,
19
],
[
19,
24,
85
]
],
[
[
867,
24,
1166
],
[
1166,
40,
85
]
],
[
[
867,
63,
1089
],
[
1089,
24,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Dolasetron and Dolase... |
DB00450 | DB06176 | 78 | 1,342 | [
"DDInter603",
"DDInter1616"
] | Droperidol | Romidepsin | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
78,
25,
1342
]
],
[
[
78,
23,
112
],
[
112,
23,
1342
]
],
[
[
78,
25,
485
],
[
485,
24,
1342
]
],
[
[
78,
25,
1616
],
[
1616,
63... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Droperidol may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may ca... |
DB05294 | DB11837 | 1,069 | 1,297 | [
"DDInter1917",
"DDInter1351"
] | Vandetanib | Osilodrostat | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1069,
25,
1297
]
],
[
[
1069,
23,
1135
],
[
1135,
23,
1297
]
],
[
[
1069,
62,
112
],
[
112,
23,
1297
]
],
[
[
1069,
64,
623
],
[
623,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronida... |
DB00108 | DB06688 | 1,066 | 1,430 | [
"DDInter1268",
"DDInter1677"
] | Natalizumab | Sipuleucel-T | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
1066,
24,
1430
]
],
[
[
1066,
25,
175
],
[
175,
24,
1430
]
],
[
[
1066,
25,
676
],
[
676,
63,
1430
]
],
[
[
1066,
64,
491
],
[
491,
... | [
[
[
"Natalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Tri... | Natalizumab may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Natalizumab may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a... |
DB09498 | DB12332 | 810 | 1,619 | [
"DDInter1715",
"DDInter1626"
] | Strontium chloride Sr-89 | Rucaparib | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
810,
24,
1619
]
],
[
[
810,
63,
309
],
[
309,
24,
1619
]
],
[
[
810,
24,
738
],
[
738,
24,
1619
]
],
[
[
810,
24,
503
],
[
503,
... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when tak... |
DB00224 | DB01067 | 215 | 959 | [
"DDInter917",
"DDInter826"
] | Indinavir | Glipizide | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
215,
24,
959
]
],
[
[
215,
63,
245
],
[
245,
40,
959
]
],
[
[
215,
24,
1411
],
[
1411,
1,
959
]
],
[
[
215,
6,
8374
],
[
8374,
4... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound)
... |
DB00398 | DB09083 | 79 | 880 | [
"DDInter1702",
"DDInter996"
] | Sorafenib | Ivabradine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
79,
25,
880
]
],
[
[
79,
24,
480
],
[
480,
24,
880
]
],
[
[
79,
24,
159
],
[
159,
63,
880
]
],
[
[
79,
63,
1051
],
[
1051,
24,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol",... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB06210 | DB14491 | 72 | 428 | [
"DDInter631",
"DDInter725"
] | Eltrombopag | Ferrous fumarate | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
72,
24,
428
]
],
[
[
72,
24,
1193
],
[
1193,
23,
428
]
],
[
[
72,
24,
1384
],
[
1384,
24,
428
]
],
[
[
72,
63,
1283
],
[
1283,
2... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc gluconate"
... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Magaldr... |
DB00532 | DB01041 | 208 | 770 | [
"DDInter1152",
"DDInter1789"
] | Mephenytoin | Thalidomide | Mephenytoin is used for the treatment of refractory partial epilepsy. Mephenytoin is a solid. This compound belongs to the phenylhydantoins. These are heterocyclic aromatic compounds containing an imiazolidinedione moiety substituted by a phenyl group. Mephenytoin is known to target sodium channel protein type 5 subuni... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
208,
24,
770
]
],
[
[
208,
24,
609
],
[
609,
63,
770
]
],
[
[
208,
63,
1614
],
[
1614,
24,
770
]
],
[
[
208,
62,
168
],
[
168,
2... | [
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Mephenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide
Mephenytoin may cause a moderate interaction that could exacerbate diseases when taken with Nabilone a... |
DB13928 | DB14730 | 1,385 | 1,412 | [
"DDInter1660",
"DDInter264"
] | Semaglutide | Calaspargase pegol | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1385,
24,
1412
]
],
[
[
1385,
63,
1144
],
[
1144,
24,
1412
]
],
[
[
1385,
64,
1101
],
[
1101,
25,
1412
]
],
[
[
1385,
63,
1144
],
[
11... | [
[
[
"Semaglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Semaglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
... | Semaglutide may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Semaglutide may lead to a major life threatening interaction when taken with Bexarotene and Bexaroten... |
DB01075 | DB04861 | 1,376 | 1,592 | [
"DDInter569",
"DDInter1271"
] | Diphenhydramine | Nebivolol | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1376,
24,
1592
]
],
[
[
1376,
6,
12523
],
[
12523,
45,
1592
]
],
[
[
1376,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
1376,
63,
1528
],
[
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Co... | Diphenhydramine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Nebivolol (Compound)
Diphenhydramine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Physosti... |
DB00773 | DB08865 | 896 | 1,593 | [
"DDInter702",
"DDInter448"
] | Etoposide | Crizotinib | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
896,
24,
1593
]
],
[
[
896,
5,
11582
],
[
11582,
44,
1593
]
],
[
[
896,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
896,
18,
9202
],
[
9202,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Etoposide",
"{u} (Compound) treats {v} (Disease)",
"lung cancer"
],
[
"lung cancer",
"{u} (Disease) is treated by... | Etoposide (Compound) treats lung cancer (Disease) and lung cancer (Disease) is treated by Crizotinib (Compound)
Etoposide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Etoposide (Compound) downregulates PLK4 (Gene) and PLK4 (Gene) is bound by Crizotinib (Compound)
Etoposide (Compoun... |
DB00451 | DB01579 | 542 | 341 | [
"DDInter1064",
"DDInter1439"
] | Levothyroxine | Phendimetrazine | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Moderate | 1 | [
[
[
542,
24,
341
]
],
[
[
542,
21,
28662
],
[
28662,
60,
341
]
],
[
[
542,
24,
959
],
[
959,
24,
341
]
],
[
[
542,
24,
1281
],
[
1281,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phendimetrazine"
]
],
[
[
"Levothyroxine",
"{u} (Compound) causes {v} (Side Effect)",
"Tremor"
],
[
"Tremor",
"{u} (Side Effect) is... | Levothyroxine (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Phendimetrazine (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Phen... |
DB00284 | DB00877 | 1,647 | 629 | [
"DDInter11",
"DDInter1678"
] | Acarbose | Sirolimus | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1647,
24,
629
]
],
[
[
1647,
18,
4893
],
[
4893,
46,
629
]
],
[
[
1647,
7,
10643
],
[
10643,
46,
629
]
],
[
[
1647,
6,
8814
],
[
8814,... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Acarbose",
"{u} (Compound) downregulates {v} (Gene)",
"S100A13"
],
[
"S100A13",
"{u} (Gene) is upregulated by {v} (... | Acarbose (Compound) downregulates S100A13 (Gene) and S100A13 (Gene) is upregulated by Sirolimus (Compound)
Acarbose (Compound) upregulates EAPP (Gene) and EAPP (Gene) is upregulated by Sirolimus (Compound)
Acarbose (Compound) binds GAA (Gene) and GAA (Gene) is upregulated by Sirolimus (Compound)
Acarbose (Compound) cau... |
DB01326 | DB09268 | 1,124 | 1,662 | [
"DDInter312",
"DDInter1464"
] | Cefamandole | Picosulfuric acid | Cefamandole is also known as cephamandole. It is a parenterally administered broad-spectrum cephalosporin antibiotic. It is generally formulated as a formate ester, [cefamandole nafate]. It is no longer marketed in the United States. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1124,
24,
1662
]
],
[
[
1124,
63,
597
],
[
597,
24,
1662
]
],
[
[
1124,
1,
1323
],
[
1323,
24,
1662
]
],
[
[
1124,
40,
703
],
[
703,
... | [
[
[
"Cefamandole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Cefamandole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
... | Cefamandole may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Cefamandole (Compound) resembles Cefonicid (Compound) and Cefonicid may cause a moderate inter... |
DB00078 | DB11988 | 1,172 | 270 | [
"DDInter898",
"DDInter1321"
] | Ibritumomab tiuxetan | Ocrelizumab | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1172,
24,
270
]
],
[
[
1172,
24,
713
],
[
713,
24,
270
]
],
[
[
1172,
24,
287
],
[
287,
63,
270
]
],
[
[
1172,
25,
998
],
[
998,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimeth... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases wh... |
DB09413 | DB09564 | 1,203 | 1,296 | [
"DDInter1241",
"DDInter930"
] | Monopotassium phosphate | Insulin degludec | Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia b... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Minor | 0 | [
[
[
1203,
23,
1296
]
],
[
[
1203,
62,
1445
],
[
1445,
24,
1296
]
],
[
[
1203,
62,
1445
],
[
1445,
63,
17
],
[
17,
24,
1296
]
],
[
[
1203,
... | [
[
[
"Monopotassium phosphate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Insulin degludec"
]
],
[
[
"Monopotassium phosphate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
... | Monopotassium phosphate may cause a minor interaction that can limit clinical effects when taken with Pseudoephedrine and Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Monopotassium phosphate may cause a minor interaction that can limit clinical effects... |
DB09073 | DB11003 | 951 | 748 | [
"DDInter1379",
"DDInter100"
] | Palbociclib | Anthrax vaccine | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
951,
24,
748
]
],
[
[
951,
24,
564
],
[
564,
63,
748
]
],
[
[
951,
25,
676
],
[
676,
63,
748
]
],
[
[
951,
63,
1683
],
[
1683,
2... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
],
... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib and Abemaciclib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Palbociclib may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitin... |
DB00983 | DB01242 | 480 | 1,237 | [
"DDInter776",
"DDInter410"
] | Formoterol | Clomipramine | Formoterol is an inhaled beta<sub>2</sub>-agonist used in the management of COPD and asthma that was first approved for use in the United States in 2001. It acts on bronchial smooth muscle to dilate and relax airways, and is administered as a racemic mixture of its active (R;R)- and inactive (S;S)-enantiomers. A major ... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
480,
24,
1237
]
],
[
[
480,
63,
684
],
[
684,
1,
1237
]
],
[
[
480,
24,
401
],
[
401,
24,
1237
]
],
[
[
480,
24,
9
],
[
9,
1,
... | [
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Formoterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
],
... | Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction ... |
DB00366 | DB00402 | 1,594 | 1,407 | [
"DDInter600",
"DDInter685"
] | Doxylamine | Eszopiclone | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Moderate | 1 | [
[
[
1594,
24,
1407
]
],
[
[
1594,
21,
28936
],
[
28936,
60,
1407
]
],
[
[
1594,
24,
1264
],
[
1264,
63,
1407
]
],
[
[
1594,
35,
272
],
[
2... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eszopiclone"
]
],
[
[
"Doxylamine",
"{u} (Compound) causes {v} (Side Effect)",
"Hyperhidrosis"
],
[
"Hyperhidrosis",
"{u} (Side Effect... | Doxylamine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Eszopiclone (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Eszo... |
DB00584 | DB06691 | 610 | 849 | [
"DDInter638",
"DDInter1155"
] | Enalapril | Mepyramine | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
610,
24,
849
]
],
[
[
610,
63,
1648
],
[
1648,
24,
849
]
],
[
[
610,
24,
407
],
[
407,
63,
849
]
],
[
[
610,
24,
1376
],
[
1376,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Enalapril may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may c... |
DB00372 | DB01255 | 999 | 633 | [
"DDInter1793",
"DDInter1078"
] | Thiethylperazine | Lisdexamfetamine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
999,
24,
633
]
],
[
[
999,
24,
551
],
[
551,
1,
633
]
],
[
[
999,
63,
80
],
[
80,
40,
633
]
],
[
[
999,
24,
1523
],
[
1523,
40,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzin... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Phenelzine (Compound) resembles Lisdexamfetamine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Li... |
DB00434 | DB06691 | 13 | 849 | [
"DDInter459",
"DDInter1155"
] | Cyproheptadine | Mepyramine | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
13,
24,
849
]
],
[
[
13,
63,
1594
],
[
1594,
24,
849
]
],
[
[
13,
24,
272
],
[
272,
24,
849
]
],
[
[
13,
6,
10104
],
[
10104,
45... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniram... |
DB00877 | DB06290 | 629 | 1,449 | [
"DDInter1678",
"DDInter1673"
] | Sirolimus | Simeprevir | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Moderate | 1 | [
[
[
629,
24,
1449
]
],
[
[
629,
6,
4973
],
[
4973,
45,
1449
]
],
[
[
629,
21,
29122
],
[
29122,
60,
1449
]
],
[
[
629,
63,
467
],
[
467,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simeprevir"
]
],
[
[
"Sirolimus",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Sirolimus (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Simeprevir (Compound)
Sirolimus (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Simeprevir (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Si... |
DB00745 | DB05676 | 307 | 1,513 | [
"DDInter1236",
"DDInter111"
] | Modafinil | Apremilast | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Apremilast, also known as Otezla, is a phosphodiesterase 4 (PDE4) inhibitor used to treat various types of symptoms resulting from certain inflammatory autoimmune diseases. It belongs to the same drug class as [Roflumilast] and [Crisaborole].[A181244,L7495] Initially approved in 2014, it is marketed by Celgene. In July... | Minor | 0 | [
[
[
307,
23,
1513
]
],
[
[
307,
24,
1421
],
[
1421,
63,
1513
]
],
[
[
307,
63,
1101
],
[
1101,
24,
1513
]
],
[
[
307,
25,
1017
],
[
1017,
... | [
[
[
"Modafinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Apremilast"
]
],
[
[
"Modafinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
],
[
... | Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and Betrixaban may cause a moderate interaction that could exacerbate diseases when taken with Apremilast
Modafinil may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarote... |
DB00330 | DB01041 | 238 | 770 | [
"DDInter689",
"DDInter1789"
] | Ethambutol | Thalidomide | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
238,
24,
770
]
],
[
[
238,
21,
28784
],
[
28784,
60,
770
]
],
[
[
238,
63,
168
],
[
168,
24,
770
]
],
[
[
238,
24,
597
],
[
597,
... | [
[
[
"Ethambutol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Ethambutol",
"{u} (Compound) causes {v} (Side Effect)",
"Thrombocytopenia"
],
[
"Thrombocytopenia",
"{u} (Side ... | Ethambutol (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Thalidomide (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when tak... |
DB01276 | DB06663 | 123 | 1,154 | [
"DDInter706",
"DDInter1398"
] | Exenatide | Pasireotide | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
123,
24,
1154
]
],
[
[
123,
63,
966
],
[
966,
40,
1154
]
],
[
[
123,
63,
663
],
[
663,
24,
1154
]
],
[
[
123,
24,
154
],
[
154,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that co... |
DB00569 | DB10344 | 553 | 992 | [
"DDInter775",
"DDInter818"
] | Fondaparinux | Ginger | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Ginger allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
553,
24,
992
]
],
[
[
553,
64,
1578
],
[
1578,
24,
992
]
],
[
[
553,
25,
1421
],
[
1421,
63,
992
]
],
[
[
553,
25,
1347
],
[
1347,
... | [
[
[
"Fondaparinux",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginger"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirudin",... | Fondaparinux may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Fondaparinux may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate intera... |
DB00222 | DB00559 | 245 | 152 | [
"DDInter825",
"DDInter223"
] | Glimepiride | Bosentan | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Moderate | 1 | [
[
[
245,
24,
152
]
],
[
[
245,
6,
6017
],
[
6017,
45,
152
]
],
[
[
245,
21,
29196
],
[
29196,
60,
152
]
],
[
[
245,
63,
168
],
[
168,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
]
],
[
[
"Glimepiride",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Glimepiride (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Bosentan (Compound)
Glimepiride (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Bosentan (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and... |
DB00372 | DB06203 | 999 | 1,002 | [
"DDInter1793",
"DDInter51"
] | Thiethylperazine | Alogliptin | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
999,
24,
1002
]
],
[
[
999,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
999,
24,
504
],
[
504,
24,
1002
]
],
[
[
999,
63,
176
],
[
176,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide may cause a... |
DB00630 | DB09407 | 1,485 | 853 | [
"DDInter42",
"DDInter1114"
] | Alendronic acid | Magnesium chloride | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
1485,
24,
853
]
],
[
[
1485,
24,
544
],
[
544,
24,
853
]
],
[
[
1485,
24,
460
],
[
460,
63,
853
]
],
[
[
1485,
1,
1008
],
[
1008,
... | [
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Alendronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium... | Alendronic acid may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Alendronic acid may cause a moderate interaction that could exacerbate diseases when ... |
DB00808 | DB08907 | 1,605 | 1,344 | [
"DDInter916",
"DDInter280"
] | Indapamide | Canagliflozin | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1605,
24,
1344
]
],
[
[
1605,
24,
549
],
[
549,
1,
1344
]
],
[
[
1605,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
1605,
21,
28873
],
[
28873... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Indapamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Indapamide (Compound) causes Pancreatitis (Side Effect... |
DB00501 | DB00683 | 752 | 1,382 | [
"DDInter380",
"DDInter1212"
] | Cimetidine | Midazolam | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Moderate | 1 | [
[
[
752,
24,
1382
]
],
[
[
752,
24,
1216
],
[
1216,
40,
1382
]
],
[
[
752,
63,
902
],
[
902,
40,
1382
]
],
[
[
752,
6,
8374
],
[
8374,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Midazolam (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Midazolam (Compound)
Cimeti... |
DB08865 | DB09276 | 1,593 | 381 | [
"DDInter448",
"DDInter1682"
] | Crizotinib | Sodium aurothiomalate | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
1593,
24,
381
]
],
[
[
1593,
63,
491
],
[
491,
24,
381
]
],
[
[
1593,
24,
350
],
[
350,
24,
381
]
],
[
[
1593,
24,
1480
],
[
1480,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon al... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Crizotinib may cause a moderate interaction that could exacerbate diseases when... |
DB00570 | DB00754 | 147 | 157 | [
"DDInter1936",
"DDInter696"
] | Vinblastine | Ethotoin | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
147,
24,
157
]
],
[
[
147,
24,
759
],
[
759,
40,
157
]
],
[
[
147,
18,
10375
],
[
10375,
57,
157
]
],
[
[
147,
21,
28921
],
[
28921,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Vinblastine (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Ethotoin (Compound)
Vinblastine (Compound) causes Dizziness (Side Effect) ... |
DB01110 | DB01149 | 86 | 851 | [
"DDInter1209",
"DDInter1274"
] | Miconazole | Nefazodone | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
86,
24,
851
]
],
[
[
86,
24,
673
],
[
673,
40,
851
]
],
[
[
86,
63,
827
],
[
827,
40,
851
]
],
[
[
86,
6,
8374
],
[
8374,
45,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Nefazodone (Compound)
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Nefazodone (Compound... |
DB01182 | DB09078 | 371 | 1,228 | [
"DDInter1534",
"DDInter1036"
] | Propafenone | Lenvatinib | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
371,
24,
1228
]
],
[
[
371,
62,
112
],
[
112,
23,
1228
]
],
[
[
371,
24,
609
],
[
609,
24,
1228
]
],
[
[
371,
63,
1264
],
[
1264,
... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Propafenone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Propafenone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin an... |
DB01169 | DB04946 | 57 | 924 | [
"DDInter120",
"DDInter907"
] | Arsenic trioxide | Iloperidone | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
57,
25,
924
]
],
[
[
57,
64,
1664
],
[
1664,
1,
924
]
],
[
[
57,
64,
1425
],
[
1425,
25,
924
]
],
[
[
57,
25,
519
],
[
519,
40,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risperidone"
],
[
"Risperidone... | Arsenic trioxide may lead to a major life threatening interaction when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Arsenic trioxide may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when taken ... |
DB00087 | DB00860 | 599 | 891 | [
"DDInter41",
"DDInter1513"
] | Alemtuzumab | Prednisolone | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
599,
24,
891
]
],
[
[
599,
24,
175
],
[
175,
40,
891
]
],
[
[
599,
24,
167
],
[
167,
1,
891
]
],
[
[
599,
24,
384
],
[
384,
63,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Pred... |
DB06589 | DB12941 | 1,250 | 466 | [
"DDInter1400",
"DDInter481"
] | Pazopanib | Darolutamide | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1250,
24,
466
]
],
[
[
1250,
64,
1622
],
[
1622,
23,
466
]
],
[
[
1250,
24,
1623
],
[
1623,
23,
466
]
],
[
[
1250,
63,
336
],
[
336,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Pazopanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voriconazole"
],
[
"Voricona... | Pazopanib may lead to a major life threatening interaction when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium and Isavuconazoniu... |
DB00398 | DB01182 | 79 | 371 | [
"DDInter1702",
"DDInter1534"
] | Sorafenib | Propafenone | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Moderate | 1 | [
[
[
79,
24,
371
]
],
[
[
79,
63,
847
],
[
847,
1,
371
]
],
[
[
79,
24,
675
],
[
675,
40,
371
]
],
[
[
79,
24,
455
],
[
455,
24,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atomoxetine"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Propafenone (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Propa... |
DB00631 | DB12267 | 372 | 1,476 | [
"DDInter405",
"DDInter233"
] | Clofarabine | Brigatinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
372,
24,
1476
]
],
[
[
372,
63,
168
],
[
168,
23,
1476
]
],
[
[
372,
24,
629
],
[
629,
24,
1476
]
],
[
[
372,
63,
1184
],
[
1184,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolim... |
DB03404 | DB09079 | 765 | 1,496 | [
"DDInter855",
"DDInter1296"
] | Hemin | Nintedanib | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Moderate | 1 | [
[
[
765,
24,
1496
]
],
[
[
765,
63,
20
],
[
20,
24,
1496
]
],
[
[
765,
24,
365
],
[
365,
24,
1496
]
],
[
[
765,
24,
1421
],
[
1421,
... | [
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nintedanib"
]
],
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tenecteplase"
],
[
"Ten... | Hemin may cause a moderate interaction that could exacerbate diseases when taken with Tenecteplase and Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Nintedanib
Hemin may cause a moderate interaction that could exacerbate diseases when taken with Dalteparin and Dalteparin m... |
DB00284 | DB09278 | 1,647 | 852 | [
"DDInter11",
"DDInter24"
] | Acarbose | Activated charcoal | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Activated charcoal, or activated carbon, is an amorphous form of carbon prepared from incomplete combustion of carbonaceous organic matter. It is activated by an oxidizing gas flow at high temperature passed over its surface to make a fine network of pores, producing a material with large surface area and high affinity... | Moderate | 1 | [
[
[
1647,
24,
852
]
],
[
[
1647,
24,
1178
],
[
1178,
24,
852
]
],
[
[
1647,
25,
1377
],
[
1377,
24,
852
]
],
[
[
1647,
23,
126
],
[
126,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Activated charcoal"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Activated charcoal
Acarbose may lead to a major life threatening interaction when taken with Leflunomide and Leflun... |
DB00500 | DB09135 | 24 | 1,211 | [
"DDInter1831",
"DDInter967"
] | Tolmetin | Ioxilan | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Major | 2 | [
[
[
24,
25,
1211
]
],
[
[
24,
24,
712
],
[
712,
25,
1211
]
],
[
[
24,
1,
831
],
[
831,
25,
1211
]
],
[
[
24,
63,
1645
],
[
1645,
25,... | [
[
[
"Tolmetin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioxilan"
]
],
[
[
"Tolmetin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
"Olsalazine",
... | Tolmetin may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may lead to a major life threatening interaction when taken with Ioxilan
Tolmetin (Compound) resembles Indomethacin (Compound) and Indomethacin may lead to a major life threatening interaction when taken w... |
DB00934 | DB05812 | 413 | 1,374 | [
"DDInter1124",
"DDInter8"
] | Maprotiline | Abiraterone | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
413,
24,
1374
]
],
[
[
413,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
413,
21,
28661
],
[
28661,
60,
1374
]
],
[
[
413,
62,
112
],
[
112,... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Maprotiline",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound... | Maprotiline (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Maprotiline (Compound) causes Acute coronary syndrome (Side Effect) and Acute coronary syndrome (Side Effect) is caused by Abiraterone (Compound)
Maprotiline may cause a minor interaction that can limit clinical effects when... |
DB00877 | DB14761 | 629 | 242 | [
"DDInter1678",
"DDInter1578"
] | Sirolimus | Remdesivir | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
629,
24,
242
]
],
[
[
629,
24,
1130
],
[
1130,
24,
242
]
],
[
[
629,
63,
467
],
[
467,
24,
242
]
],
[
[
629,
64,
1512
],
[
1512,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Sim... |
DB01124 | DB01267 | 1,411 | 519 | [
"DDInter1828",
"DDInter1381"
] | Tolbutamide | Paliperidone | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
1411,
24,
519
]
],
[
[
1411,
63,
1664
],
[
1664,
1,
519
]
],
[
[
1411,
24,
924
],
[
924,
1,
519
]
],
[
[
1411,
21,
29232
],
[
29232,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (... |
DB04835 | DB09280 | 1,655 | 1,604 | [
"DDInter1125",
"DDInter1101"
] | Maraviroc | Lumacaftor | Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Mara... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1655,
25,
1604
]
],
[
[
1655,
63,
1061
],
[
1061,
24,
1604
]
],
[
[
1655,
24,
1468
],
[
1468,
24,
1604
]
],
[
[
1655,
24,
1491
],
[
14... | [
[
[
"Maraviroc",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Maraviroc",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
"Treprostin... | Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Maraviroc may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponat... |
DB01618 | DB09472 | 776 | 1,383 | [
"DDInter1239",
"DDInter1693"
] | Molindone | Sodium sulfate | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
776,
24,
1383
]
],
[
[
776,
64,
1311
],
[
1311,
24,
1383
]
],
[
[
776,
63,
1528
],
[
1528,
24,
1383
]
],
[
[
776,
24,
407
],
[
407,
... | [
[
[
"Molindone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Molindone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
],
[
"Meto... | Molindone may lead to a major life threatening interaction when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Molindone may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine and Physosti... |
DB08904 | DB12498 | 375 | 76 | [
"DDInter342",
"DDInter1238"
] | Certolizumab pegol | Mogamulizumab | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Mogamulizumab is a humanized monoclonal antibody (mAb) directed against CC chemokine receptor 4 (CCR4) for the treatment of Mycosis Fungoides (MF) and Sézary Syndrome (SS), the most common subtypes of cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become canc... | Major | 2 | [
[
[
375,
25,
76
]
],
[
[
375,
62,
1461
],
[
1461,
23,
76
]
],
[
[
375,
23,
1193
],
[
1193,
23,
76
]
],
[
[
375,
64,
1531
],
[
1531,
... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mogamulizumab"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
... | Certolizumab pegol may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab
Certolizumab pegol may cause a minor interaction that can limit clinical effects when taken with Zinc gluco... |
DB00046 | DB00655 | 1,179 | 559 | [
"DDInter940",
"DDInter682"
] | Insulin lispro | Estrone | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion... | Moderate | 1 | [
[
[
1179,
24,
559
]
],
[
[
1179,
24,
35
],
[
35,
40,
559
]
],
[
[
1179,
24,
1438
],
[
1438,
1,
559
]
],
[
[
1179,
24,
167
],
[
167,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
],
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Estrone (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Estrone (Compound)
... |
DB01069 | DB01261 | 401 | 170 | [
"DDInter1533",
"DDInter1679"
] | Promethazine | Sitagliptin | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
401,
24,
170
]
],
[
[
401,
6,
4973
],
[
4973,
45,
170
]
],
[
[
401,
21,
28921
],
[
28921,
60,
170
]
],
[
[
401,
24,
52
],
[
52,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound... | Promethazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sitagliptin (Compound)
Promethazine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Sitagliptin (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide a... |
DB01114 | DB11963 | 272 | 1,045 | [
"DDInter362",
"DDInter465"
] | Chlorpheniramine | Dacomitinib | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
272,
24,
1045
]
],
[
[
272,
63,
479
],
[
479,
23,
1045
]
],
[
[
272,
74,
211
],
[
211,
23,
1045
]
],
[
[
272,
63,
1664
],
[
1664,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Donepezil"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a minor interaction that can limit clinical effects when taken with Dacomitinib
Chlorpheniramine (Compound) resembles Tolterodine (Compound) and Chlorpheniramine may cause a moderate intera... |
DB00446 | DB08860 | 597 | 788 | [
"DDInter351",
"DDInter1479"
] | Chloramphenicol | Pitavastatin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
597,
24,
788
]
],
[
[
597,
24,
671
],
[
671,
1,
788
]
],
[
[
597,
24,
700
],
[
700,
40,
788
]
],
[
[
597,
6,
3486
],
[
3486,
45,... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pita... |
DB00339 | DB09122 | 1,182 | 1,613 | [
"DDInter1547",
"DDInter1409"
] | Pyrazinamide | Peginterferon beta-1a | A pyrazine that is used therapeutically as an antitubercular agent. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1182,
24,
1613
]
],
[
[
1182,
24,
267
],
[
267,
24,
1613
]
],
[
[
1182,
63,
1560
],
[
1560,
24,
1613
]
],
[
[
1182,
24,
1662
],
[
1662... | [
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken with Pegasp... |
DB00544 | DB01208 | 970 | 945 | [
"DDInter757",
"DDInter1705"
] | Fluorouracil | Sparfloxacin | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
970,
23,
945
]
],
[
[
970,
23,
739
],
[
739,
1,
945
]
],
[
[
970,
62,
1176
],
[
1176,
1,
945
]
],
[
[
970,
21,
28787
],
[
28787,
... | [
[
[
"Fluorouracil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Fluorouracil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
... | Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Sparfloxacin... |
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