drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00501 | DB00980 | 752 | 969 | [
"DDInter380",
"DDInter1564"
] | Cimetidine | Ramelteon | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Moderate | 1 | [
[
[
752,
24,
969
]
],
[
[
752,
6,
7950
],
[
7950,
45,
969
]
],
[
[
752,
21,
28714
],
[
28714,
60,
969
]
],
[
[
752,
62,
1684
],
[
1684,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramelteon"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Cimetidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ramelteon (Compound)
Cimetidine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Ramelteon (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Caffeine and Caffeine may... |
DB00344 | DB00486 | 1,302 | 1,614 | [
"DDInter1543",
"DDInter1253"
] | Protriptyline | Nabilone | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
1302,
24,
1614
]
],
[
[
1302,
24,
530
],
[
530,
1,
1614
]
],
[
[
1302,
21,
28769
],
[
28769,
60,
1614
]
],
[
[
1302,
24,
999
],
[
999,... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Protriptyline (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Nabilone (Compound)
Protriptyline may cause a mo... |
DB00501 | DB01253 | 752 | 628 | [
"DDInter380",
"DDInter664"
] | Cimetidine | Ergometrine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Moderate | 1 | [
[
[
752,
24,
628
]
],
[
[
752,
63,
1131
],
[
1131,
40,
628
]
],
[
[
752,
24,
826
],
[
826,
40,
628
]
],
[
[
752,
6,
8374
],
[
8374,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergometrine"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methysergide"
],
[... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) resembles Ergometrine (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Ergometrine (Comp... |
DB00559 | DB06595 | 152 | 1,491 | [
"DDInter223",
"DDInter1214"
] | Bosentan | Midostaurin | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
152,
24,
1491
]
],
[
[
152,
24,
1135
],
[
1135,
62,
1491
]
],
[
[
152,
24,
112
],
[
112,
23,
1491
]
],
[
[
152,
24,
761
],
[
761,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidaz... |
DB00281 | DB14724 | 608 | 48 | [
"DDInter1066",
"DDInter634"
] | Lidocaine | Emapalumab | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
608,
24,
48
]
],
[
[
608,
62,
362
],
[
362,
24,
48
]
],
[
[
608,
35,
1401
],
[
1401,
24,
48
]
],
[
[
608,
24,
143
],
[
143,
24,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Phenytoin"
],
[
"... | Lidocaine may cause a minor interaction that can limit clinical effects when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Lidocaine (Compound) resembles Procainamide (Compound) and Lidocaine may cause a moderate interaction that could exac... |
DB00197 | DB04845 | 1,324 | 309 | [
"DDInter1881",
"DDInter1001"
] | Troglitazone | Ixabepilone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1324,
24,
309
]
],
[
[
1324,
24,
307
],
[
307,
23,
309
]
],
[
[
1324,
24,
1419
],
[
1419,
24,
309
]
],
[
[
1324,
24,
1619
],
[
1619,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Ixabepilone
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatini... |
DB08880 | DB11793 | 1,510 | 738 | [
"DDInter1771",
"DDInter1297"
] | Teriflunomide | Niraparib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Major | 2 | [
[
[
1510,
25,
738
]
],
[
[
1510,
24,
466
],
[
466,
63,
738
]
],
[
[
1510,
64,
1213
],
[
1213,
24,
738
]
],
[
[
1510,
24,
496
],
[
496,
... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Niraparib"
]
],
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Dar... | Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Teriflunomide may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may... |
DB01015 | DB06616 | 1,247 | 594 | [
"DDInter1724",
"DDInter224"
] | Sulfamethoxazole | Bosutinib | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Minor | 0 | [
[
[
1247,
23,
594
]
],
[
[
1247,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1247,
21,
29034
],
[
29034,
60,
594
]
],
[
[
1247,
62,
112
],
[
112,
... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bosutinib"
]
],
[
[
"Sulfamethoxazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Sulfamethoxazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Sulfamethoxazole (Compound) causes Urinary tract disorder (Side Effect) and Urinary tract disorder (Side Effect) is caused by Bosutinib (Compound)
Sulfamethoxazole may cause a minor interaction that can limit clinical eff... |
DB00424 | DB00545 | 19 | 751 | [
"DDInter896",
"DDInter1548"
] | Hyoscyamine | Pyridostigmine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Moderate | 1 | [
[
[
19,
24,
751
]
],
[
[
19,
24,
1372
],
[
1372,
1,
751
]
],
[
[
19,
21,
28751
],
[
28751,
60,
751
]
],
[
[
19,
24,
61
],
[
61,
63,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pyridostigmine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neostigmine"
],
... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Neostigmine and Neostigmine (Compound) resembles Pyridostigmine (Compound)
Hyoscyamine (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Pyridostigmine (Compound)
Hyoscyamine may cause a modera... |
DB00295 | DB01619 | 475 | 830 | [
"DDInter1244",
"DDInter1441"
] | Morphine | Phenindamine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
475,
24,
830
]
],
[
[
475,
24,
1251
],
[
1251,
1,
830
]
],
[
[
475,
24,
537
],
[
537,
40,
830
]
],
[
[
475,
63,
357
],
[
357,
24... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Mirtazapine and Mirtazapine (Compound) resembles Phenindamine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
... |
DB00445 | DB08908 | 322 | 713 | [
"DDInter655",
"DDInter564"
] | Epirubicin | Dimethyl fumarate | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
322,
24,
713
]
],
[
[
322,
25,
996
],
[
996,
24,
713
]
],
[
[
322,
24,
4
],
[
4,
24,
713
]
],
[
[
322,
24,
725
],
[
725,
63,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
],
[
"Be... | Epirubicin may lead to a major life threatening interaction when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate a... |
DB00477 | DB01612 | 216 | 1,637 | [
"DDInter363",
"DDInter92"
] | Chlorpromazine | Amyl Nitrite | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
216,
24,
1637
]
],
[
[
216,
1,
1216
],
[
1216,
24,
1637
]
],
[
[
216,
64,
475
],
[
475,
24,
1637
]
],
[
[
216,
35,
401
],
[
401,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) resembles {v} (Compound)",
"Flurazepam"
],
[
"Flurazepam",
"{u} may cause... | Chlorpromazine (Compound) resembles Flurazepam (Compound) and Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Chlorpromazine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerba... |
DB00911 | DB01174 | 458 | 697 | [
"DDInter1811",
"DDInter1442"
] | Tinidazole | Phenobarbital | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
458,
24,
697
]
],
[
[
458,
63,
759
],
[
759,
1,
697
]
],
[
[
458,
63,
536
],
[
536,
40,
697
]
],
[
[
458,
6,
8374
],
[
8374,
45,... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenobarbital (Co... |
DB00106 | DB00862 | 618 | 1,005 | [
"DDInter4",
"DDInter1918"
] | Abarelix | Vardenafil | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Moderate | 1 | [
[
[
618,
24,
1005
]
],
[
[
618,
23,
112
],
[
112,
63,
1005
]
],
[
[
618,
24,
1494
],
[
1494,
24,
1005
]
],
[
[
618,
24,
1133
],
[
1133,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vardenafil"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Vardenafil
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Palonosetron and Palo... |
DB00502 | DB12245 | 1,300 | 823 | [
"DDInter853",
"DDInter1863"
] | Haloperidol | Triclabendazole | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Major | 2 | [
[
[
1300,
25,
823
]
],
[
[
1300,
23,
112
],
[
112,
23,
823
]
],
[
[
1300,
64,
1010
],
[
1010,
24,
823
]
],
[
[
1300,
24,
28
],
[
28,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
]
],
[
[
"Haloperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Me... | Haloperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Haloperidol may lead to a major life threatening interaction when taken with Mefloquine and Mefloquine m... |
DB01357 | DB06404 | 890 | 1,514 | [
"DDInter1160",
"DDInter869"
] | Mestranol | Human C1-esterase inhibitor | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Moderate | 1 | [
[
[
890,
24,
1514
]
],
[
[
890,
40,
1438
],
[
1438,
24,
1514
]
],
[
[
890,
1,
984
],
[
984,
24,
1514
]
],
[
[
890,
1,
1546
],
[
1546,
... | [
[
[
"Mestranol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human C1-esterase inhibitor"
]
],
[
[
"Mestranol",
"{u} (Compound) resembles {v} (Compound)",
"Estradiol"
],
[
"Estradiol",
"{u} may ca... | Mestranol (Compound) resembles Estradiol (Compound) and Estradiol may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Mestranol (Compound) resembles Danazol (Compound) and Danazol may cause a moderate interaction that could exacerbate diseases when taken with Huma... |
DB00060 | DB06710 | 912 | 1,546 | [
"DDInter947",
"DDInter1193"
] | Interferon beta-1a | Methyltestosterone | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | A synthetic anabolic steroid used for treating men with testosterone deficiency or similar androgen replacement therapies. Also, has antineoplastic properties and so has been used secondarily in women with advanced breast cancer. Methyltestosterone is a schedule III drug in the US. | Moderate | 1 | [
[
[
912,
24,
1546
]
],
[
[
912,
24,
155
],
[
155,
1,
1546
]
],
[
[
912,
24,
984
],
[
984,
40,
1546
]
],
[
[
912,
24,
384
],
[
384,
6... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flu... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Methyltestosterone (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Danazol and Danazol (Compound) rese... |
DB00063 | DB01050 | 366 | 848 | [
"DDInter659",
"DDInter900"
] | Eptifibatide | Ibuprofen | Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
366,
24,
848
]
],
[
[
366,
23,
297
],
[
297,
62,
848
]
],
[
[
366,
24,
831
],
[
831,
24,
848
]
],
[
[
366,
25,
1047
],
[
1047,
6... | [
[
[
"Eptifibatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Eptifibatide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
... | Eptifibatide may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin ma... |
DB00454 | DB00758 | 1,349 | 1,347 | [
"DDInter1150",
"DDInter413"
] | Meperidine | Clopidogrel | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Moderate | 1 | [
[
[
1349,
24,
1347
]
],
[
[
1349,
6,
7603
],
[
7603,
45,
1347
]
],
[
[
1349,
21,
28778
],
[
28778,
60,
1347
]
],
[
[
1349,
24,
578
],
[
57... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
]
],
[
[
"Meperidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2B6"
],
[
"CYP2B6",
"{u} (Gene) is bound by {v} (Compound)"... | Meperidine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Clopidogrel (Compound)
Meperidine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Clopidogrel (Compound)
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB06228 | DB10344 | 792 | 992 | [
"DDInter1609",
"DDInter818"
] | Rivaroxaban | Ginger | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Ginger allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
792,
24,
992
]
],
[
[
792,
64,
1578
],
[
1578,
24,
992
]
],
[
[
792,
25,
1421
],
[
1421,
63,
992
]
],
[
[
792,
25,
802
],
[
802,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginger"
]
],
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lepirudin"
],
[
"Lepirudin",
... | Rivaroxaban may lead to a major life threatening interaction when taken with Lepirudin and Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Ginger
Rivaroxaban may lead to a major life threatening interaction when taken with Betrixaban and Betrixaban may cause a moderate interact... |
DB00398 | DB08870 | 79 | 850 | [
"DDInter1702",
"DDInter228"
] | Sorafenib | Brentuximab vedotin | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
79,
24,
850
]
],
[
[
79,
63,
1570
],
[
1570,
24,
850
]
],
[
[
79,
24,
896
],
[
896,
24,
850
]
],
[
[
79,
24,
1155
],
[
1155,
63,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide ... |
DB01083 | DB06414 | 1,142 | 655 | [
"DDInter1348",
"DDInter703"
] | Orlistat | Etravirine | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1142,
24,
655
]
],
[
[
1142,
24,
786
],
[
786,
40,
655
]
],
[
[
1142,
6,
8374
],
[
8374,
45,
655
]
],
[
[
1142,
21,
28723
],
[
28723,
... | [
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Orlistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
],
[
... | Orlistat may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Orlistat (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Etravirine (Compound)
Orlistat (Compound) causes Malnutrition (Side Effect) and Malnutriti... |
DB00981 | DB01203 | 1,528 | 699 | [
"DDInter1462",
"DDInter1255"
] | Physostigmine | Nadolol | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Nadolol is a nonselective beta adrenal receptor blocker that is used to lower blood pressure.[L7922,L7925] Nonselective beta adrenal receptor blockers may no longer be first line in the treatment of hypertension as newer generations of beta adrenal receptor blockers have higher selectivity and offer better rates of adv... | Moderate | 1 | [
[
[
1528,
24,
699
]
],
[
[
1528,
24,
729
],
[
729,
1,
699
]
],
[
[
1528,
63,
887
],
[
887,
1,
699
]
],
[
[
1528,
21,
28722
],
[
28722,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nadolol"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
],
[... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Penbutolol and Penbutolol (Compound) resembles Nadolol (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Nadolol (Compound)
Phys... |
DB01069 | DB09061 | 401 | 1,627 | [
"DDInter1533",
"DDInter284"
] | Promethazine | Cannabidiol | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
401,
24,
1627
]
],
[
[
401,
24,
760
],
[
760,
62,
1627
]
],
[
[
401,
24,
609
],
[
609,
23,
1627
]
],
[
[
401,
63,
600
],
[
600,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and... |
DB00773 | DB08871 | 896 | 36 | [
"DDInter702",
"DDInter666"
] | Etoposide | Eribulin | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
896,
24,
36
]
],
[
[
896,
24,
221
],
[
221,
63,
36
]
],
[
[
896,
24,
563
],
[
563,
24,
36
]
],
[
[
896,
63,
1463
],
[
1463,
24,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (form... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Etoposide may cause a moderate ... |
DB00850 | DB09330 | 1,630 | 985 | [
"DDInter1432",
"DDInter1352"
] | Perphenazine | Osimertinib | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1630,
25,
985
]
],
[
[
1630,
23,
112
],
[
112,
23,
985
]
],
[
[
1630,
24,
480
],
[
480,
24,
985
]
],
[
[
1630,
24,
657
],
[
657,
... | [
[
[
"Perphenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Perphenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and... |
DB00679 | DB06589 | 684 | 1,250 | [
"DDInter1796",
"DDInter1400"
] | Thioridazine | Pazopanib | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
684,
25,
1250
]
],
[
[
684,
6,
7950
],
[
7950,
45,
1250
]
],
[
[
684,
18,
2049
],
[
2049,
46,
1250
]
],
[
[
684,
7,
16192
],
[
16192,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Pazo... | Thioridazine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Pazopanib (Compound)
Thioridazine (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is upregulated by Pazopanib (Compound)
Thioridazine (Compound) upregulates KIAA0355 (Gene) and KIAA0355 (Gene) is upregulated by Pazopanib (Compound)
Thior... |
DB00352 | DB11952 | 482 | 800 | [
"DDInter1814",
"DDInter612"
] | Tioguanine | Duvelisib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
482,
24,
800
]
],
[
[
482,
24,
467
],
[
467,
24,
800
]
],
[
[
482,
63,
440
],
[
440,
24,
800
]
],
[
[
482,
24,
270
],
[
270,
63,... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Filgrastim and Filgr... |
DB00928 | DB08908 | 1,426 | 713 | [
"DDInter148",
"DDInter564"
] | Azacitidine | Dimethyl fumarate | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1426,
24,
713
]
],
[
[
1426,
24,
4
],
[
4,
24,
713
]
],
[
[
1426,
24,
270
],
[
270,
63,
713
]
],
[
[
1426,
1,
1488
],
[
1488,
24... | [
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesu... | Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Azacitidine may cause a moderate interaction that could exacerbate disease... |
DB00330 | DB08871 | 238 | 36 | [
"DDInter689",
"DDInter666"
] | Ethambutol | Eribulin | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
238,
24,
36
]
],
[
[
238,
24,
1488
],
[
1488,
24,
36
]
],
[
[
238,
63,
168
],
[
168,
24,
36
]
],
[
[
238,
24,
384
],
[
384,
63,
... | [
[
[
"Ethambutol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Ethambutol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortez... |
DB00106 | DB01100 | 618 | 1,568 | [
"DDInter4",
"DDInter1470"
] | Abarelix | Pimozide | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Major | 2 | [
[
[
618,
25,
1568
]
],
[
[
618,
25,
78
],
[
78,
40,
1568
]
],
[
[
618,
23,
112
],
[
112,
23,
1568
]
],
[
[
618,
24,
455
],
[
455,
24... | [
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{u} (Compou... | Abarelix may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effect... |
DB00748 | DB00835 | 662 | 100 | [
"DDInter297",
"DDInter245"
] | Carbinoxamine | Brompheniramine | Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
662,
35,
100
]
],
[
[
662,
35,
832
],
[
832,
24,
100
]
],
[
[
662,
63,
508
],
[
508,
24,
100
]
],
[
[
662,
1,
11786
],
[
11786,
... | [
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Carbinoxamine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate ... | Carbinoxamine (Compound) resembles Brompheniramine (Compound) and
Carbinoxamine (Compound) resembles Tripelennamine (Compound) and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseas... |
DB00719 | DB11160 | 1,219 | 337 | [
"DDInter149",
"DDInter1459"
] | Azatadine | Phenyltoloxamine | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
1219,
24,
337
]
],
[
[
1219,
23,
771
],
[
771,
62,
337
]
],
[
[
1219,
63,
1594
],
[
1594,
24,
337
]
],
[
[
1219,
24,
1511
],
[
1511,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Azatadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
],
... | Azatadine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Phenyltoloxamine
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and ... |
DB00911 | DB09293 | 458 | 116 | [
"DDInter1811",
"DDInter954"
] | Tinidazole | Iodide I-131 | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
458,
24,
116
]
],
[
[
458,
24,
1487
],
[
1487,
24,
116
]
],
[
[
458,
24,
1434
],
[
1434,
63,
116
]
],
[
[
458,
63,
126
],
[
126,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]... | Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Ben... |
DB00414 | DB00991 | 590 | 97 | [
"DDInter16",
"DDInter1358"
] | Acetohexamide | Oxaprozin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Moderate | 1 | [
[
[
590,
24,
97
]
],
[
[
590,
24,
939
],
[
939,
40,
97
]
],
[
[
590,
63,
362
],
[
362,
1,
97
]
],
[
[
590,
24,
1274
],
[
1274,
24,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaprozin"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Oxaprozin (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Oxaprozin (Co... |
DB00372 | DB00564 | 999 | 1,236 | [
"DDInter1793",
"DDInter293"
] | Thiethylperazine | Carbamazepine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
999,
24,
1236
]
],
[
[
999,
24,
1405
],
[
1405,
40,
1236
]
],
[
[
999,
63,
362
],
[
362,
1,
1236
]
],
[
[
999,
24,
401
],
[
401,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzapr... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine (Compound) resembles Carbamazepine (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles... |
DB00319 | DB01024 | 790 | 1,096 | [
"DDInter1474",
"DDInter1252"
] | Piperacillin | Mycophenolic acid | Semisynthetic, broad-spectrum, ampicillin derived ureidopenicillin antibiotic proposed for pseudomonas infections. It is also used in combination with other antibiotics. | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
790,
24,
1096
]
],
[
[
790,
18,
2884
],
[
2884,
46,
1096
]
],
[
[
790,
18,
2697
],
[
2697,
57,
1096
]
],
[
[
790,
21,
28666
],
[
28666... | [
[
[
"Piperacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Piperacillin",
"{u} (Compound) downregulates {v} (Gene)",
"ECH1"
],
[
"ECH1",
"{u} (Gene) is upregulate... | Piperacillin (Compound) downregulates ECH1 (Gene) and ECH1 (Gene) is upregulated by Mycophenolic acid (Compound)
Piperacillin (Compound) downregulates VPS28 (Gene) and VPS28 (Gene) is downregulated by Mycophenolic acid (Compound)
Piperacillin (Compound) causes Nervous system disorder (Side Effect) and Nervous system di... |
DB00398 | DB01246 | 79 | 820 | [
"DDInter1702",
"DDInter45"
] | Sorafenib | Alimemazine | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
79,
24,
820
]
],
[
[
79,
24,
1335
],
[
1335,
24,
820
]
],
[
[
79,
24,
675
],
[
675,
25,
820
]
],
[
[
79,
24,
508
],
[
508,
1,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Dextropropoxyphe... |
DB01182 | DB06168 | 371 | 1,531 | [
"DDInter1534",
"DDInter281"
] | Propafenone | Canakinumab | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
371,
24,
1531
]
],
[
[
371,
24,
1362
],
[
1362,
63,
1531
]
],
[
[
371,
24,
1213
],
[
1213,
24,
1531
]
],
[
[
371,
63,
1031
],
[
1031,
... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatini... |
DB00215 | DB06788 | 1,230 | 1,616 | [
"DDInter388",
"DDInter864"
] | Citalopram | Histrelin | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
1230,
25,
1616
]
],
[
[
1230,
23,
112
],
[
112,
23,
1616
]
],
[
[
1230,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
1230,
63,
1179
],
[
1179... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Citalopram may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may cause... |
DB00209 | DB00774 | 352 | 1,577 | [
"DDInter1886",
"DDInter889"
] | Trospium | Hydroflumethiazide | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Minor | 0 | [
[
[
352,
23,
1577
]
],
[
[
352,
23,
359
],
[
359,
40,
1577
]
],
[
[
352,
23,
504
],
[
504,
1,
1577
]
],
[
[
352,
21,
28989
],
[
28989,
... | [
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Trospium",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chlorothiazide"
],
... | Trospium may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Trospium may cause a minor interaction that can limit clinical effects when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resemb... |
DB00741 | DB01263 | 167 | 859 | [
"DDInter885",
"DDInter1494"
] | Hydrocortisone | Posaconazole | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
167,
24,
859
]
],
[
[
167,
6,
4973
],
[
4973,
45,
859
]
],
[
[
167,
21,
28762
],
[
28762,
60,
859
]
],
[
[
167,
63,
1101
],
[
1101,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Com... | Hydrocortisone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Hydrocortisone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bexarot... |
DB00095 | DB11921 | 66 | 1,019 | [
"DDInter623",
"DDInter492"
] | Efalizumab | Deflazacort | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
66,
24,
1019
]
],
[
[
66,
23,
1193
],
[
1193,
23,
1019
]
],
[
[
66,
24,
270
],
[
270,
63,
1019
]
],
[
[
66,
24,
1367
],
[
1367,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and ... |
DB09263 | DB09481 | 1,436 | 460 | [
"DDInter1399",
"DDInter1113"
] | Patiromer | Magnesium carbonate | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Major | 2 | [
[
[
1436,
25,
460
]
],
[
[
1436,
24,
853
],
[
853,
24,
460
]
],
[
[
1436,
24,
428
],
[
428,
63,
460
]
],
[
[
1436,
63,
1596
],
[
1596,
... | [
[
[
"Patiromer",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Patiromer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
],
[
... | Patiromer may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride and Magnesium chloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium carbonate
Patiromer may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00988 | DB01069 | 817 | 401 | [
"DDInter584",
"DDInter1533"
] | Dopamine | Promethazine | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
817,
24,
401
]
],
[
[
817,
25,
1264
],
[
1264,
63,
401
]
],
[
[
817,
24,
820
],
[
820,
63,
401
]
],
[
[
817,
63,
104
],
[
104,
2... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Dopamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
],
[
"Doxepin",
... | Dopamine may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a mode... |
DB01259 | DB12161 | 392 | 730 | [
"DDInter1024",
"DDInter512"
] | Lapatinib | Deutetrabenazine | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
392,
24,
730
]
],
[
[
392,
62,
112
],
[
112,
23,
730
]
],
[
[
392,
63,
322
],
[
322,
24,
730
]
],
[
[
392,
24,
971
],
[
971,
24,... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Lapatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Lapatinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Deutetrabenazine
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and ... |
DB00400 | DB01227 | 353 | 1,301 | [
"DDInter843",
"DDInter1043"
] | Griseofulvin | Levacetylmethadol | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Levacetylmethadol is a narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence. Levacetylmethadol was withdrawn from use in the European Union due to its high risk of QT interval prolongation. The production of levacetylmethadol in the US has ceased as well... | Major | 2 | [
[
[
353,
25,
1301
]
],
[
[
353,
24,
307
],
[
307,
1,
1301
]
],
[
[
353,
63,
576
],
[
576,
1,
1301
]
],
[
[
353,
6,
8374
],
[
8374,
4... | [
[
[
"Griseofulvin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levacetylmethadol"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
"... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Levacetylmethadol (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Levacetylmethad... |
DB00872 | DB05773 | 1,080 | 1,047 | [
"DDInter438",
"DDInter1848"
] | Conivaptan | Trastuzumab emtansine | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1080,
24,
1047
]
],
[
[
1080,
24,
310
],
[
310,
63,
1047
]
],
[
[
1080,
24,
458
],
[
458,
24,
1047
]
],
[
[
1080,
64,
467
],
[
467,
... | [
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Conivaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
... | Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Tinidazo... |
DB00494 | DB06691 | 1,533 | 849 | [
"DDInter646",
"DDInter1155"
] | Entacapone | Mepyramine | Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson's disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa conce... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1533,
24,
849
]
],
[
[
1533,
63,
1594
],
[
1594,
24,
849
]
],
[
[
1533,
24,
272
],
[
272,
24,
849
]
],
[
[
1533,
24,
407
],
[
407,
... | [
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Entacapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Entacapone may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and ... |
DB00999 | DB01050 | 504 | 848 | [
"DDInter883",
"DDInter900"
] | Hydrochlorothiazide | Ibuprofen | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
504,
24,
848
]
],
[
[
504,
24,
1053
],
[
1053,
1,
848
]
],
[
[
504,
6,
10612
],
[
10612,
45,
848
]
],
[
[
504,
21,
28929
],
[
28929,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazi... | Hydrochlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine and Procarbazine (Compound) resembles Ibuprofen (Compound)
Hydrochlorothiazide (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Ibuprofen (Compound)
Hydrochlorothiazide (Compound) causes Confus... |
DB06288 | DB11110 | 607 | 603 | [
"DDInter77",
"DDInter1115"
] | Amisulpride | Magnesium citrate | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
607,
24,
603
]
],
[
[
607,
64,
57
],
[
57,
24,
603
]
],
[
[
607,
25,
1616
],
[
1616,
24,
603
]
],
[
[
607,
63,
870
],
[
870,
24,... | [
[
[
"Amisulpride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Amisulpride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Amisulpride may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Amisulpride may lead to a major life threatening interaction when taken with Histrelin and Histrelin may ca... |
DB00312 | DB01114 | 1,023 | 272 | [
"DDInter1423",
"DDInter362"
] | Pentobarbital | Chlorpheniramine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1023,
24,
272
]
],
[
[
1023,
24,
849
],
[
849,
63,
272
]
],
[
[
1023,
24,
128
],
[
128,
24,
272
]
],
[
[
1023,
6,
8374
],
[
8374,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Dexbromph... |
DB00263 | DB00912 | 1,029 | 473 | [
"DDInter1727",
"DDInter1581"
] | Sulfisoxazole | Repaglinide | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1029,
24,
473
]
],
[
[
1029,
40,
698
],
[
698,
63,
473
]
],
[
[
1029,
1,
1247
],
[
1247,
63,
473
]
],
[
[
1029,
24,
384
],
[
384,
... | [
[
[
"Sulfisoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Sulfisoxazole",
"{u} (Compound) resembles {v} (Compound)",
"Sulfadoxine"
],
[
"Sulfadoxine",
"{u} may cause ... | Sulfisoxazole (Compound) resembles Sulfadoxine (Compound) and Sulfadoxine may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when t... |
DB00635 | DB04834 | 1,573 | 276 | [
"DDInter1515",
"DDInter1571"
] | Prednisone | Rapacuronium | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Moderate | 1 | [
[
[
1573,
24,
276
]
],
[
[
1573,
63,
1031
],
[
1031,
24,
276
]
],
[
[
1573,
24,
1287
],
[
1287,
24,
276
]
],
[
[
1573,
40,
251
],
[
251,
... | [
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rapacuronium"
]
],
[
[
"Prednisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
... | Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Amphotericin B ... |
DB00912 | DB01165 | 473 | 1,539 | [
"DDInter1581",
"DDInter1325"
] | Repaglinide | Ofloxacin | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Major | 2 | [
[
[
473,
25,
1539
]
],
[
[
473,
64,
1467
],
[
1467,
1,
1539
]
],
[
[
473,
25,
945
],
[
945,
40,
1539
]
],
[
[
473,
25,
739
],
[
739,
... | [
[
[
"Repaglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ofloxacin"
]
],
[
[
"Repaglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxacin"
],
[
"Enoxacin",
"{u} (Com... | Repaglinide may lead to a major life threatening interaction when taken with Enoxacin and Enoxacin (Compound) resembles Ofloxacin (Compound)
Repaglinide may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Compound)
Repaglinide may lead to a majo... |
DB00356 | DB09122 | 1,315 | 1,613 | [
"DDInter366",
"DDInter1409"
] | Chlorzoxazone | Peginterferon beta-1a | A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202) | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1315,
24,
1613
]
],
[
[
1315,
24,
267
],
[
267,
24,
1613
]
],
[
[
1315,
63,
1560
],
[
1560,
24,
1613
]
],
[
[
1315,
25,
1377
],
[
1377... | [
[
[
"Chlorzoxazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Chlorzoxazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone... | Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Chlorzoxazone may cause a moderate interaction that could exacerbate diseases when taken with Pega... |
DB00694 | DB01023 | 51 | 409 | [
"DDInter485",
"DDInter716"
] | Daunorubicin | Felodipine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
51,
24,
409
]
],
[
[
51,
24,
336
],
[
336,
40,
409
]
],
[
[
51,
6,
8374
],
[
8374,
45,
409
]
],
[
[
51,
18,
6692
],
[
6692,
46,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Nifedipine and Nifedipine (Compound) resembles Felodipine (Compound)
Daunorubicin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Felodipine (Compound)
Daunorubicin (Compound) downregulates CGRRF1 (Gene) and CGRRF1... |
DB11986 | DB12301 | 484 | 907 | [
"DDInter648",
"DDInter585"
] | Entrectinib | Doravirine | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
484,
23,
907
]
],
[
[
484,
63,
1478
],
[
1478,
23,
907
]
],
[
[
484,
24,
159
],
[
159,
62,
907
]
],
[
[
484,
64,
600
],
[
600,
2... | [
[
[
"Entrectinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Entrectinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB00781 | DB01362 | 1,481 | 497 | [
"DDInter1489",
"DDInter960"
] | Polymyxin B | Iohexol | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1481,
25,
497
]
],
[
[
1481,
25,
258
],
[
258,
40,
497
]
],
[
[
1481,
21,
28719
],
[
28719,
60,
497
]
],
[
[
1481,
24,
242
],
[
242,
... | [
[
[
"Polymyxin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Polymyxin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (Com... | Polymyxin B may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Polymyxin B (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Iohexol (Compound)
Polymyxin B may cause a moderate interaction that could exacerbate diseases... |
DB00808 | DB09135 | 1,605 | 1,211 | [
"DDInter916",
"DDInter967"
] | Indapamide | Ioxilan | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
1605,
24,
1211
]
],
[
[
1605,
40,
811
],
[
811,
24,
1211
]
],
[
[
1605,
63,
1648
],
[
1648,
24,
1211
]
],
[
[
1605,
63,
1287
],
[
1287... | [
[
[
"Indapamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Indapamide",
"{u} (Compound) resembles {v} (Compound)",
"Metolazone"
],
[
"Metolazone",
"{u} may cause a moderate i... | Indapamide (Compound) resembles Metolazone (Compound) and Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Indapamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could ... |
DB00285 | DB00427 | 1,100 | 1,233 | [
"DDInter1927",
"DDInter1879"
] | Venlafaxine | Triprolidine | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Moderate | 1 | [
[
[
1100,
24,
1233
]
],
[
[
1100,
6,
12523
],
[
12523,
45,
1233
]
],
[
[
1100,
24,
662
],
[
662,
63,
1233
]
],
[
[
1100,
1,
643
],
[
643,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triprolidine"
]
],
[
[
"Venlafaxine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compoun... | Venlafaxine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Triprolidine (Compound)
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine
Venlaf... |
DB00313 | DB01390 | 556 | 1,117 | [
"DDInter1913",
"DDInter1683"
] | Valproic acid | Sodium bicarbonate | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
556,
23,
1117
]
],
[
[
556,
21,
29093
],
[
29093,
60,
1117
]
],
[
[
556,
24,
663
],
[
663,
23,
1117
]
],
[
[
556,
23,
752
],
[
752,
... | [
[
[
"Valproic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Valproic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Fatigue"
],
[
"Fatigue",
"{u} (Side Effect)... | Valproic acid (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Sodium bicarbonate (Compound)
Valproic acid may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken ... |
DB00620 | DB01149 | 175 | 851 | [
"DDInter1855",
"DDInter1274"
] | Triamcinolone | Nefazodone | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Major | 2 | [
[
[
175,
25,
851
]
],
[
[
175,
6,
8374
],
[
8374,
45,
851
]
],
[
[
175,
18,
7359
],
[
7359,
57,
851
]
],
[
[
175,
21,
28762
],
[
28762,
... | [
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
]
],
[
[
"Triamcinolone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"N... | Triamcinolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound)
Triamcinolone (Compound) downregulates TXNDC9 (Gene) and TXNDC9 (Gene) is downregulated by Nefazodone (Compound)
Triamcinolone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nefazodone (Com... |
DB00366 | DB01121 | 1,594 | 94 | [
"DDInter600",
"DDInter1437"
] | Doxylamine | Phenacemide | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Phenacemide is used to control certain seizures in the treatment of epilepsy. This medicine acts on the central nervous system (CNS) to reduce the number and severity of seizures. | Moderate | 1 | [
[
[
1594,
24,
94
]
],
[
[
1594,
25,
551
],
[
551,
1,
94
]
],
[
[
1594,
24,
1614
],
[
1614,
24,
94
]
],
[
[
1594,
24,
1264
],
[
1264,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide"
]
],
[
[
"Doxylamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
],
[
"Phenelzin... | Doxylamine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Phenacemide (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseas... |
DB00647 | DB13074 | 675 | 877 | [
"DDInter528",
"DDInter1110"
] | Dextropropoxyphene | Macimorelin | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
675,
25,
877
]
],
[
[
675,
23,
112
],
[
112,
23,
877
]
],
[
[
675,
63,
85
],
[
85,
24,
877
]
],
[
[
675,
24,
913
],
[
913,
24,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Dextropropoxyphene may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with At... |
DB00374 | DB00398 | 1,061 | 79 | [
"DDInter1852",
"DDInter1702"
] | Treprostinil | Sorafenib | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Moderate | 1 | [
[
[
1061,
24,
79
]
],
[
[
1061,
25,
292
],
[
292,
40,
79
]
],
[
[
1061,
6,
6017
],
[
6017,
45,
79
]
],
[
[
1061,
7,
3163
],
[
3163,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
]
],
[
[
"Treprostinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
],
[
"Regora... | Treprostinil may lead to a major life threatening interaction when taken with Regorafenib and Regorafenib (Compound) resembles Sorafenib (Compound)
Treprostinil (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Sorafenib (Compound)
Treprostinil (Compound) upregulates TSC22D3 (Gene) and TSC22D3 (Gene) is upre... |
DB00363 | DB09038 | 695 | 1,450 | [
"DDInter419",
"DDInter636"
] | Clozapine | Empagliflozin | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
695,
24,
1450
]
],
[
[
695,
25,
485
],
[
485,
24,
1450
]
],
[
[
695,
24,
659
],
[
659,
63,
1450
]
],
[
[
695,
63,
1179
],
[
1179,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentamidine"
],
[
"Pentamid... | Clozapine may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and Vilanterol may cau... |
DB00005 | DB08871 | 1,057 | 36 | [
"DDInter687",
"DDInter666"
] | Etanercept | Eribulin | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1057,
25,
36
]
],
[
[
1057,
24,
221
],
[
221,
63,
36
]
],
[
[
1057,
25,
563
],
[
563,
24,
36
]
],
[
[
1057,
24,
1463
],
[
1463,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inac... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Etanercept may lead to a major... |
DB01254 | DB11866 | 1,213 | 1,068 | [
"DDInter484",
"DDInter1618"
] | Dasatinib | Romosozumab | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant to other osteoperosis therapies. Romosozumab prevents bone resorption and induces the formation of bone though it... | Moderate | 1 | [
[
[
1213,
24,
1068
]
],
[
[
1213,
25,
1069
],
[
1069,
24,
1068
]
],
[
[
1213,
24,
1250
],
[
1250,
24,
1068
]
],
[
[
1213,
63,
1195
],
[
11... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romosozumab"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
],
[
"Vandetanib"... | Dasatinib may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may cause a moderate interaction that could exacerbate diseases when taken with Romosozumab
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pazopanib may cause a m... |
DB01115 | DB06372 | 336 | 259 | [
"DDInter1291",
"DDInter1594"
] | Nifedipine | Rilonacept | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
336,
24,
259
]
],
[
[
336,
24,
1619
],
[
1619,
63,
259
]
],
[
[
336,
25,
1456
],
[
1456,
63,
259
]
],
[
[
336,
63,
1573
],
[
1573,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
... | Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Nifedipine may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax may cause a ... |
DB00048 | DB00975 | 1,595 | 1,317 | [
"DDInter435",
"DDInter573"
] | Collagenase clostridium histolyticum | Dipyridamole | Collagenase clostridium histolyticum is an enzyme produced by the bacterium Clostridium histolyticum. It is beneficial in the breakdown of collagen plaques for the treatment of Dupuytren's contracture and Peyronie's disease. The topical formulation is used for the debridement of necrotic tissue due to burns or chronic ... | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Moderate | 1 | [
[
[
1595,
24,
1317
]
],
[
[
1595,
24,
714
],
[
714,
63,
1317
]
],
[
[
1595,
24,
1167
],
[
1167,
24,
1317
]
],
[
[
1595,
63,
20
],
[
20,
... | [
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dipyridamole"
]
],
[
[
"Collagenase clostridium histolyticum",
"{u} may cause a moderate interaction that could exacerbate diseases wh... | Collagenase clostridium histolyticum may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Dipyridamole
Collagenase clostridium histolyticum may cause a moderate interaction that could exacerb... |
DB09065 | DB09073 | 760 | 951 | [
"DDInter424",
"DDInter1379"
] | Cobicistat | Palbociclib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
760,
25,
951
]
],
[
[
760,
23,
907
],
[
907,
62,
951
]
],
[
[
760,
62,
318
],
[
318,
23,
951
]
],
[
[
760,
25,
1476
],
[
1476,
6... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Cobicistat",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
"Doravirine"... | Cobicistat may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Cobicistat may cause a minor interaction that can limit clinical effects when taken with Escitalopram and Escitalop... |
DB00180 | DB09065 | 1,351 | 760 | [
"DDInter749",
"DDInter424"
] | Flunisolide | Cobicistat | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1351,
24,
760
]
],
[
[
1351,
24,
34
],
[
34,
24,
760
]
],
[
[
1351,
40,
167
],
[
167,
24,
760
]
],
[
[
1351,
24,
68
],
[
68,
63,... | [
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
],
... | Flunisolide may cause a moderate interaction that could exacerbate diseases when taken with Fosamprenavir and Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Flunisolide (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a moderate intera... |
DB00277 | DB01149 | 1,031 | 851 | [
"DDInter1791",
"DDInter1274"
] | Theophylline | Nefazodone | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
1031,
24,
851
]
],
[
[
1031,
23,
1242
],
[
1242,
24,
851
]
],
[
[
1031,
6,
8374
],
[
8374,
45,
851
]
],
[
[
1031,
21,
28762
],
[
28762... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cetirizine"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Cetirizine and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone
Theophylline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nefazodone (Compound)
Theophylline (Co... |
DB00682 | DB00774 | 126 | 1,577 | [
"DDInter1951",
"DDInter889"
] | Warfarin | Hydroflumethiazide | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Minor | 0 | [
[
[
126,
23,
1577
]
],
[
[
126,
23,
359
],
[
359,
40,
1577
]
],
[
[
126,
62,
323
],
[
323,
40,
1577
]
],
[
[
126,
23,
504
],
[
504,
... | [
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Warfarin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chlorothiazide"
],
... | Warfarin may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Warfarin may cause a minor interaction that can limit clinical effects when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) resemb... |
DB00333 | DB01041 | 576 | 770 | [
"DDInter1166",
"DDInter1789"
] | Methadone | Thalidomide | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
576,
24,
770
]
],
[
[
576,
6,
7524
],
[
7524,
45,
770
]
],
[
[
576,
21,
28789
],
[
28789,
60,
770
]
],
[
[
576,
25,
609
],
[
609,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Methadone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Methadone (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Methadone may lead to a major life threatening interaction when taken with Clarithromy... |
DB00427 | DB01069 | 1,233 | 401 | [
"DDInter1879",
"DDInter1533"
] | Triprolidine | Promethazine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1233,
24,
401
]
],
[
[
1233,
24,
146
],
[
146,
24,
401
]
],
[
[
1233,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1233,
6,
12523
],
[
12523,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and... |
DB00352 | DB09061 | 482 | 1,627 | [
"DDInter1814",
"DDInter284"
] | Tioguanine | Cannabidiol | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
482,
24,
1627
]
],
[
[
482,
24,
609
],
[
609,
23,
1627
]
],
[
[
482,
63,
600
],
[
600,
23,
1627
]
],
[
[
482,
24,
351
],
[
351,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB04868 | DB12364 | 478 | 1,421 | [
"DDInter1293",
"DDInter200"
] | Nilotinib | Betrixaban | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
478,
24,
1421
]
],
[
[
478,
64,
1091
],
[
1091,
24,
1421
]
],
[
[
478,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
478,
63,
529
],
[
529,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
"Amprenavir",... | Nilotinib may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a ... |
DB00681 | DB01099 | 1,287 | 1,272 | [
"DDInter85",
"DDInter744"
] | Amphotericin B | Flucytosine | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
1287,
24,
1272
]
],
[
[
1287,
21,
29209
],
[
29209,
60,
1272
]
],
[
[
1287,
24,
485
],
[
485,
24,
1272
]
],
[
[
1287,
24,
1186
],
[
11... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Amphotericin B",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side Effect) ... | Amphotericin B (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Flucytosine (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00397 | DB04896 | 1,466 | 901 | [
"DDInter1458",
"DDInter1220"
] | Phenylpropanolamine | Milnacipran | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Major | 2 | [
[
[
1466,
25,
901
]
],
[
[
1466,
25,
41
],
[
41,
1,
901
]
],
[
[
1466,
6,
7390
],
[
7390,
45,
901
]
],
[
[
1466,
21,
28786
],
[
28786,
... | [
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Milnacipran"
]
],
[
[
"Phenylpropanolamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Levomilnacipran"
],
[
"L... | Phenylpropanolamine may lead to a major life threatening interaction when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Phenylpropanolamine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Milnacipran (Compound)
Phenylpropanolamine (Compound) causes Urinary reten... |
DB00014 | DB00916 | 521 | 112 | [
"DDInter839",
"DDInter1202"
] | Goserelin | Metronidazole | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Minor | 0 | [
[
[
521,
23,
112
]
],
[
[
521,
21,
29612
],
[
29612,
60,
112
]
],
[
[
521,
24,
847
],
[
847,
23,
112
]
],
[
[
521,
24,
843
],
[
843,
... | [
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of libido"
],
[
"Loss of libido",
"{u} (Side Effect... | Goserelin (Compound) causes Loss of libido (Side Effect) and Loss of libido (Side Effect) is caused by Metronidazole (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine may cause a minor interaction that can limit clinical effects when taken w... |
DB00582 | DB12130 | 1,622 | 1,017 | [
"DDInter1946",
"DDInter1094"
] | Voriconazole | Lorlatinib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Major | 2 | [
[
[
1622,
25,
1017
]
],
[
[
1622,
63,
608
],
[
608,
23,
1017
]
],
[
[
1622,
64,
1101
],
[
1101,
23,
1017
]
],
[
[
1622,
64,
590
],
[
590,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lorlatinib"
]
],
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocai... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Voriconazole may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause ... |
DB01114 | DB06702 | 272 | 573 | [
"DDInter362",
"DDInter731"
] | Chlorpheniramine | Fesoterodine | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
272,
24,
573
]
],
[
[
272,
74,
211
],
[
211,
1,
573
]
],
[
[
272,
63,
494
],
[
494,
1,
573
]
],
[
[
272,
6,
12523
],
[
12523,
45... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Chlorpheniramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate disease... | Chlorpheniramine (Compound) resembles Tolterodine (Compound) and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when... |
DB15091 | DB15719 | 676 | 487 | [
"DDInter1901",
"DDInter171"
] | Upadacitinib | Belantamab mafodotin | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Major | 2 | [
[
[
676,
25,
487
]
],
[
[
676,
63,
810
],
[
810,
24,
487
]
],
[
[
676,
64,
259
],
[
259,
24,
487
]
],
[
[
676,
64,
976
],
[
976,
25,... | [
[
[
"Upadacitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Upadacitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
... | Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89 and Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Upadacitinib may lead to a major life threatening interaction when taken... |
DB00673 | DB00924 | 723 | 1,405 | [
"DDInter112",
"DDInter454"
] | Aprepitant | Cyclobenzaprine | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Moderate | 1 | [
[
[
723,
24,
1405
]
],
[
[
723,
63,
1236
],
[
1236,
1,
1405
]
],
[
[
723,
24,
939
],
[
939,
1,
1405
]
],
[
[
723,
6,
7950
],
[
7950,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
],
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Carbamazepine and Carbamazepine (Compound) resembles Cyclobenzaprine (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Cyclo... |
DB00444 | DB06317 | 63 | 1,626 | [
"DDInter1765",
"DDInter630"
] | Teniposide | Elotuzumab | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Moderate | 1 | [
[
[
63,
24,
1626
]
],
[
[
63,
24,
973
],
[
973,
24,
1626
]
],
[
[
63,
63,
1463
],
[
1463,
24,
1626
]
],
[
[
63,
24,
200
],
[
200,
63... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elotuzumab"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
[
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovast... |
DB00072 | DB15091 | 550 | 676 | [
"DDInter1846",
"DDInter1901"
] | Trastuzumab | Upadacitinib | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
550,
25,
676
]
],
[
[
550,
24,
1430
],
[
1430,
24,
676
]
],
[
[
550,
63,
1184
],
[
1184,
25,
676
]
],
[
[
550,
24,
58
],
[
58,
2... | [
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipu... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and ... |
DB00647 | DB08899 | 675 | 129 | [
"DDInter528",
"DDInter649"
] | Dextropropoxyphene | Enzalutamide | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
675,
24,
129
]
],
[
[
675,
24,
918
],
[
918,
1,
129
]
],
[
[
675,
6,
8374
],
[
8374,
45,
129
]
],
[
[
675,
21,
28921
],
[
28921,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutam... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Dextropropoxyphene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Dextropropoxyphene (Compound) causes Dizzi... |
DB01236 | DB01611 | 679 | 1,487 | [
"DDInter1664",
"DDInter893"
] | Sevoflurane | Hydroxychloroquine | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
679,
25,
1487
]
],
[
[
679,
63,
1520
],
[
1520,
25,
1487
]
],
[
[
679,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
679,
24,
286
],
[
286,
... | [
[
[
"Sevoflurane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Sevoflurane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"... | Sevoflurane may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Sevoflurane (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compo... |
DB00951 | DB09043 | 1,072 | 135 | [
"DDInter986",
"DDInter36"
] | Isoniazid | Albiglutide | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1072,
24,
135
]
],
[
[
1072,
63,
126
],
[
126,
23,
135
]
],
[
[
1072,
62,
870
],
[
870,
24,
135
]
],
[
[
1072,
63,
176
],
[
176,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Isoniazid may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone and Fludrocort... |
DB11581 | DB12364 | 1,456 | 1,421 | [
"DDInter1926",
"DDInter200"
] | Venetoclax | Betrixaban | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
1456,
24,
1421
]
],
[
[
1456,
64,
1091
],
[
1091,
24,
1421
]
],
[
[
1456,
25,
1017
],
[
1017,
24,
1421
]
],
[
[
1456,
63,
529
],
[
529... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Venetoclax",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
"Amprenavir... | Venetoclax may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Venetoclax may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate inte... |
DB00420 | DB08865 | 508 | 1,593 | [
"DDInter1532",
"DDInter448"
] | Promazine | Crizotinib | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
508,
25,
1593
]
],
[
[
508,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
508,
7,
6886
],
[
6886,
46,
1593
]
],
[
[
508,
18,
6212
],
[
6212,
... | [
[
[
"Promazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Promazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizotini... | Promazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Promazine (Compound) upregulates MSMO1 (Gene) and MSMO1 (Gene) is upregulated by Crizotinib (Compound)
Promazine (Compound) downregulates CSRP1 (Gene) and CSRP1 (Gene) is downregulated by Crizotinib (Compound)
Promazine may cau... |
DB00377 | DB00454 | 1,494 | 1,349 | [
"DDInter1382",
"DDInter1150"
] | Palonosetron | Meperidine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Major | 2 | [
[
[
1494,
25,
1349
]
],
[
[
1494,
25,
901
],
[
901,
1,
1349
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
1349
]
],
[
[
1494,
21,
28681
],
[
28681... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meperidine"
]
],
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Milnacipran"
],
[
"Milnacipran",
... | Palonosetron may lead to a major life threatening interaction when taken with Milnacipran and Milnacipran (Compound) resembles Meperidine (Compound)
Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Meperidine (Compound)
Palonosetron (Compound) causes Hypersensitivity (Side Effect) and Hypersens... |
DB00661 | DB09333 | 122 | 278 | [
"DDInter1928",
"DDInter963"
] | Verapamil | Iopodic acid | Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina, and was the first calcium channel antagonist to be introduced into therapy in the early 1960s. It is a member of the non-dihydropyridine class of calcium channel blockers, which includes ... | Iopodic acid, also known by the name of ipodate, is classified as a cholecystographic agent formed by a weak organic acid that contains a tri-iodinated benzene ring with iodine at positions 2, 4 and 6. Due to its particular structure, it presents a high degree of lipid solubility and a radiopaque property. It was devel... | Moderate | 1 | [
[
[
122,
24,
278
]
],
[
[
122,
63,
1648
],
[
1648,
24,
278
]
],
[
[
122,
24,
1527
],
[
1527,
24,
278
]
],
[
[
122,
63,
1648
],
[
1648,
... | [
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopodic acid"
]
],
[
[
"Verapamil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iopodic acid
Verapamil may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid and... |
DB00889 | DB08864 | 1,133 | 786 | [
"DDInter840",
"DDInter1595"
] | Granisetron | Rilpivirine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
1133,
24,
786
]
],
[
[
1133,
24,
655
],
[
655,
1,
786
]
],
[
[
1133,
6,
8374
],
[
8374,
45,
786
]
],
[
[
1133,
21,
28698
],
[
28698,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
],
[... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Granisetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Granisetron (Compound) causes Insomnia (Side Effect) and Insom... |
DB00333 | DB01611 | 576 | 1,487 | [
"DDInter1166",
"DDInter893"
] | Methadone | Hydroxychloroquine | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
576,
25,
1487
]
],
[
[
576,
25,
1520
],
[
1520,
25,
1487
]
],
[
[
576,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
576,
21,
28658
],
[
2865... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Methadone may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Methadone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Methadone (Compound) causes Vomiti... |
DB00078 | DB00242 | 1,172 | 1,064 | [
"DDInter898",
"DDInter392"
] | Ibritumomab tiuxetan | Cladribine | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Major | 2 | [
[
[
1172,
25,
1064
]
],
[
[
1172,
24,
1270
],
[
1270,
63,
1064
]
],
[
[
1172,
63,
1253
],
[
1253,
24,
1064
]
],
[
[
1172,
25,
477
],
[
477... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified pr... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Cladribine
Ibritumomab tiuxetan may cause a moderate inte... |
DB08865 | DB08912 | 1,593 | 1,040 | [
"DDInter448",
"DDInter462"
] | Crizotinib | Dabrafenib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1593,
24,
1040
]
],
[
[
1593,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1593,
7,
13128
],
[
13128,
46,
1040
]
],
[
[
1593,
6,
2653
],
[
265... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Crizotinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Crizotinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Crizotinib (Compound) upregulates NARFL (Gene) and NARFL (Gene) is upregulated by Dabrafenib (Compound)
Crizotinib (Compound) binds LIMK2 (Gene) and LIMK2 (Gene) is upregulated by Dabrafenib (Compound)
Crizotinib (Compound) down... |
DB00262 | DB01097 | 552 | 1,377 | [
"DDInter302",
"DDInter1033"
] | Carmustine | Leflunomide | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
552,
25,
1377
]
],
[
[
552,
6,
7950
],
[
7950,
45,
1377
]
],
[
[
552,
21,
29062
],
[
29062,
60,
1377
]
],
[
[
552,
63,
1461
],
[
1461,... | [
[
[
"Carmustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Carmustine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Leflun... | Carmustine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Leflunomide (Compound)
Carmustine (Compound) causes Neutropenia (Side Effect) and Neutropenia (Side Effect) is caused by Leflunomide (Compound)
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and... |
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