drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01064 | DB11718 | 1,148 | 927 | [
"DDInter987",
"DDInter640"
] | Isoprenaline | Encorafenib | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1148,
24,
927
]
],
[
[
1148,
63,
216
],
[
216,
24,
927
]
],
[
[
1148,
24,
659
],
[
659,
24,
927
]
],
[
[
1148,
24,
1399
],
[
1399,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpromazine"
],... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Vilanter... |
DB00465 | DB06715 | 886 | 239 | [
"DDInter1010",
"DDInter1500"
] | Ketorolac | Potassium Iodide | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperthyroidism (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyr... | Moderate | 1 | [
[
[
886,
24,
239
]
],
[
[
886,
21,
29196
],
[
29196,
60,
239
]
],
[
[
886,
24,
877
],
[
877,
63,
239
]
],
[
[
886,
25,
1274
],
[
1274,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Potassium Iodide"
]
],
[
[
"Ketorolac",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (Side Effec... | Ketorolac (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Potassium Iodide (Compound)
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Macimorelin and Macimorelin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00295 | DB08822 | 475 | 911 | [
"DDInter1244",
"DDInter156"
] | Morphine | Azilsartan medoxomil | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
475,
24,
911
]
],
[
[
475,
63,
217
],
[
217,
1,
911
]
],
[
[
475,
24,
240
],
[
240,
1,
911
]
],
[
[
475,
21,
28880
],
[
28880,
6... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesartan"
],
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Losartan and Losartan (Compound) resembles Azilsartan medoxomil... |
DB00544 | DB01030 | 970 | 869 | [
"DDInter757",
"DDInter1835"
] | Fluorouracil | Topotecan | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
970,
24,
869
]
],
[
[
970,
6,
17404
],
[
17404,
45,
869
]
],
[
[
970,
7,
2969
],
[
2969,
46,
869
]
],
[
[
970,
21,
29276
],
[
29276,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Fluorouracil",
"{u} (Compound) binds {v} (Gene)",
"ABCG2"
],
[
"ABCG2",
"{u} (Gene) is bound by {v} (Compound)"... | Fluorouracil (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Topotecan (Compound)
Fluorouracil (Compound) upregulates CDKN1A (Gene) and CDKN1A (Gene) is upregulated by Topotecan (Compound)
Fluorouracil (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Effect) is caused by Topotecan (Compound)... |
DB00316 | DB00747 | 474 | 1,442 | [
"DDInter14",
"DDInter1647"
] | Acetaminophen | Scopolamine | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Minor | 0 | [
[
[
474,
23,
1442
]
],
[
[
474,
23,
19
],
[
19,
24,
1442
]
],
[
[
474,
6,
4973
],
[
4973,
45,
1442
]
],
[
[
474,
21,
28766
],
[
28766,
... | [
[
[
"Acetaminophen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Scopolamine"
]
],
[
[
"Acetaminophen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyoscyamine"
],
... | Acetaminophen may cause a minor interaction that can limit clinical effects when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Acetaminophen (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Scopolamine (Compound)
Acetaminophe... |
DB00065 | DB00401 | 581 | 84 | [
"DDInter923",
"DDInter1298"
] | Infliximab | Nisoldipine | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Moderate | 1 | [
[
[
581,
24,
84
]
],
[
[
581,
24,
854
],
[
854,
1,
84
]
],
[
[
581,
24,
376
],
[
376,
40,
84
]
],
[
[
581,
24,
1031
],
[
1031,
23,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nisoldipine"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nimodipine"
],
[
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Nimodipine and Nimodipine (Compound) resembles Nisoldipine (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Nisoldipine (Compound... |
DB00439 | DB09280 | 289 | 1,604 | [
"DDInter341",
"DDInter1101"
] | Cerivastatin | Lumacaftor | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Moderate | 1 | [
[
[
289,
24,
1604
]
],
[
[
289,
24,
522
],
[
522,
24,
1604
]
],
[
[
289,
24,
1501
],
[
1501,
63,
1604
]
],
[
[
289,
24,
1480
],
[
1480,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lumacaftor"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zafirlukast"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib and ... |
DB00357 | DB08882 | 1,051 | 1,281 | [
"DDInter71",
"DDInter1070"
] | Aminoglutethimide | Linagliptin | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1051,
24,
1281
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
1051,
21,
28762
],
[
28762,
60,
1281
]
],
[
[
1051,
25,
879
],
[
87... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Aminoglutethimide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Linagliptin (Compound)
Aminoglutethimide may lead to a major life threatening interaction when taken with Lumateperone ... |
DB00283 | DB00599 | 701 | 682 | [
"DDInter395",
"DDInter1795"
] | Clemastine | Thiopental | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | Moderate | 1 | [
[
[
701,
24,
682
]
],
[
[
701,
24,
1023
],
[
1023,
1,
682
]
],
[
[
701,
6,
8374
],
[
8374,
45,
682
]
],
[
[
701,
24,
401
],
[
401,
6... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiopental"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],
[... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Thiopental (Compound)
Clemastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Thiopental (Compound)
Clemastine may cause a moderate interaction that could exace... |
DB00622 | DB06663 | 1,081 | 1,154 | [
"DDInter1287",
"DDInter1398"
] | Nicardipine | Pasireotide | A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [Pub... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
1081,
24,
1154
]
],
[
[
1081,
63,
966
],
[
966,
40,
1154
]
],
[
[
1081,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1081,
40,
409
],
[
409... | [
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Nicardipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[... | Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Nicardipine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Nicardipine (Compound) resembl... |
DB01390 | DB06589 | 1,117 | 1,250 | [
"DDInter1683",
"DDInter1400"
] | Sodium bicarbonate | Pazopanib | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1117,
24,
1250
]
],
[
[
1117,
21,
28658
],
[
28658,
60,
1250
]
],
[
[
1117,
63,
14
],
[
14,
24,
1250
]
],
[
[
1117,
24,
28
],
[
28,
... | [
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Sodium bicarbonate",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Ef... | Sodium bicarbonate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when t... |
DB00358 | DB00581 | 1,010 | 355 | [
"DDInter1140",
"DDInter1018"
] | Mefloquine | Lactulose | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Moderate | 1 | [
[
[
1010,
24,
355
]
],
[
[
1010,
21,
28722
],
[
28722,
60,
355
]
],
[
[
1010,
24,
286
],
[
286,
62,
355
]
],
[
[
1010,
24,
1262
],
[
1262,... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lactulose"
]
],
[
[
"Mefloquine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {... | Mefloquine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lactulose (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken wit... |
DB01211 | DB08873 | 609 | 74 | [
"DDInter393",
"DDInter221"
] | Clarithromycin | Boceprevir | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
609,
24,
74
]
],
[
[
609,
6,
4973
],
[
4973,
45,
74
]
],
[
[
609,
54,
19146
],
[
19146,
15,
74
]
],
[
[
609,
21,
28769
],
[
28769,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Clarithromycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compo... | Clarithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Boceprevir (Compound)
Clarithromycin (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Boceprevir (Compound)
Clarithromycin (Compound) causes Feeling a... |
DB00581 | DB00734 | 355 | 1,664 | [
"DDInter1018",
"DDInter1605"
] | Lactulose | Risperidone | Lactulose is a synthetic disaccharide derivative of lactose that is most commonly used as a laxative agent despite also being formally indicated to serve as an adjunct therapy in treating portal-systemic encephalopathy (PSE).[FDA Label,L6199,L6202] Despite being first synthesized in 1929, investigations regarding its p... | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Moderate | 1 | [
[
[
355,
24,
1664
]
],
[
[
355,
24,
924
],
[
924,
40,
1664
]
],
[
[
355,
21,
29152
],
[
29152,
60,
1664
]
],
[
[
355,
24,
1616
],
[
1616,
... | [
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
]
],
[
[
"Lactulose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
],
[
... | Lactulose may cause a moderate interaction that could exacerbate diseases when taken with Iloperidone and Iloperidone (Compound) resembles Risperidone (Compound)
Lactulose (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Risperidone (Compound)
Lactulose may cause a moderate interaction that ... |
DB01319 | DB08875 | 34 | 1,618 | [
"DDInter777",
"DDInter262"
] | Fosamprenavir | Cabozantinib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
34,
25,
1618
]
],
[
[
34,
25,
1135
],
[
1135,
62,
1618
]
],
[
[
34,
63,
723
],
[
723,
24,
1618
]
],
[
[
34,
24,
384
],
[
384,
63... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Fosamprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may ca... |
DB00046 | DB00365 | 1,179 | 839 | [
"DDInter940",
"DDInter842"
] | Insulin lispro | Grepafloxacin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Major | 2 | [
[
[
1179,
25,
839
]
],
[
[
1179,
24,
222
],
[
222,
62,
839
]
],
[
[
1179,
24,
1101
],
[
1101,
23,
839
]
],
[
[
1179,
24,
1385
],
[
1385,
... | [
[
[
"Insulin lispro",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Grepafloxacin"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Grepafloxacin
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene... |
DB00376 | DB06282 | 1,105 | 516 | [
"DDInter1870",
"DDInter1053"
] | Trihexyphenidyl | Levocetirizine | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1105,
24,
516
]
],
[
[
1105,
63,
701
],
[
701,
24,
516
]
],
[
[
1105,
24,
1614
],
[
1614,
24,
516
]
],
[
[
1105,
24,
407
],
[
407,
... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
... | Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Nabilon... |
DB06077 | DB09073 | 879 | 951 | [
"DDInter1102",
"DDInter1379"
] | Lumateperone | Palbociclib | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
879,
24,
951
]
],
[
[
879,
25,
1476
],
[
1476,
63,
951
]
],
[
[
879,
24,
159
],
[
159,
63,
951
]
],
[
[
879,
64,
600
],
[
600,
2... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Briga... | Lumateperone may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib... |
DB00012 | DB00722 | 1,535 | 743 | [
"DDInter479",
"DDInter1079"
] | Darbepoetin alfa | Lisinopril | Human erythropoietin with 2 aa substitutions to enhance glycosylation (5 N-linked chains), 165 residues (MW=37 kD). Produced in Chinese hamster ovary (CHO) cells by recombinant DNA technology. | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Minor | 0 | [
[
[
1535,
23,
743
]
],
[
[
1535,
23,
610
],
[
610,
40,
743
]
],
[
[
1535,
23,
1638
],
[
1638,
1,
743
]
],
[
[
1535,
23,
610
],
[
610,
... | [
[
[
"Darbepoetin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lisinopril"
]
],
[
[
"Darbepoetin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enalapril"
],
... | Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Darbepoetin alfa may cause a minor interaction that can limit clinical effects when taken with Trandolapril and Trandolapril (Compound) resembles Lisinopril (... |
DB01208 | DB01611 | 945 | 1,487 | [
"DDInter1705",
"DDInter893"
] | Sparfloxacin | Hydroxychloroquine | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
945,
25,
1487
]
],
[
[
945,
64,
1520
],
[
1520,
25,
1487
]
],
[
[
945,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
945,
63,
663
],
[
663,
... | [
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Sparfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primaquine"
],
[
"Primaquine",
... | Sparfloxacin may lead to a major life threatening interaction when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Sparfloxacin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Sparflox... |
DB10989 | DB12001 | 496 | 564 | [
"DDInter858",
"DDInter7"
] | Hepatitis A Vaccine | Abemaciclib | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
496,
24,
564
]
],
[
[
496,
63,
58
],
[
58,
24,
564
]
],
[
[
496,
24,
351
],
[
351,
24,
564
]
],
[
[
496,
24,
1476
],
[
1476,
63,... | [
[
[
"Hepatitis A Vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Hepatitis A Vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacep... | Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Ribo... |
DB00056 | DB08868 | 816 | 1,011 | [
"DDInter814",
"DDInter737"
] | Gemtuzumab ozogamicin | Fingolimod | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
816,
25,
1011
]
],
[
[
816,
24,
242
],
[
242,
63,
1011
]
],
[
[
816,
24,
1136
],
[
1136,
24,
1011
]
],
[
[
816,
25,
976
],
[
976,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
... | Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01255 | DB06589 | 633 | 1,250 | [
"DDInter1078",
"DDInter1400"
] | Lisdexamfetamine | Pazopanib | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
633,
24,
1250
]
],
[
[
633,
21,
28658
],
[
28658,
60,
1250
]
],
[
[
633,
62,
112
],
[
112,
23,
1250
]
],
[
[
633,
24,
1151
],
[
1151,
... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Lisdexamfetamine",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect... | Lisdexamfetamine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Lisdexamfetamine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00514 | DB04946 | 506 | 924 | [
"DDInter527",
"DDInter907"
] | Dextromethorphan | Iloperidone | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
506,
24,
924
]
],
[
[
506,
24,
1664
],
[
1664,
1,
924
]
],
[
[
506,
24,
519
],
[
519,
40,
924
]
],
[
[
506,
6,
21998
],
[
21998,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Ilo... |
DB00816 | DB00999 | 1,674 | 504 | [
"DDInter1346",
"DDInter883"
] | Orciprenaline | Hydrochlorothiazide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
1674,
24,
504
]
],
[
[
1674,
24,
1326
],
[
1326,
40,
504
]
],
[
[
1674,
24,
178
],
[
178,
1,
504
]
],
[
[
1674,
63,
323
],
[
323,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamid... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembl... |
DB00675 | DB00867 | 888 | 1,052 | [
"DDInter1744",
"DDInter1606"
] | Tamoxifen | Ritodrine | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Adrenergic beta-agonist used to control premature labor. | Moderate | 1 | [
[
[
888,
24,
1052
]
],
[
[
888,
40,
878
],
[
878,
1,
1052
]
],
[
[
888,
18,
2183
],
[
2183,
57,
1052
]
],
[
[
888,
24,
1220
],
[
1220,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
]
],
[
[
"Tamoxifen",
"{u} (Compound) resembles {v} (Compound)",
"Diethylstilbestrol"
],
[
"Diethylstilbestrol",
"{u} (Compo... | Tamoxifen (Compound) resembles Diethylstilbestrol (Compound) and Diethylstilbestrol (Compound) resembles Ritodrine (Compound)
Tamoxifen (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Ritodrine (Compound)
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB09330 | DB11932 | 985 | 327 | [
"DDInter1352",
"DDInter3"
] | Osimertinib | Abametapir (topical) | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
985,
24,
327
]
],
[
[
985,
25,
124
],
[
124,
63,
327
]
],
[
[
985,
62,
168
],
[
168,
24,
327
]
],
[
[
985,
24,
283
],
[
283,
63,... | [
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Osimertinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
],
[
"Glasdegib... | Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Osimertinib may lead to a major life threatening interaction when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Osimertinib may cause a m... |
DB01023 | DB09280 | 409 | 1,604 | [
"DDInter716",
"DDInter1101"
] | Felodipine | Lumacaftor | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
409,
25,
1604
]
],
[
[
409,
63,
1061
],
[
1061,
24,
1604
]
],
[
[
409,
24,
593
],
[
593,
24,
1604
]
],
[
[
409,
23,
1135
],
[
1135,
... | [
[
[
"Felodipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
"Treprost... | Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Bupropion and Bup... |
DB06772 | DB08870 | 310 | 850 | [
"DDInter259",
"DDInter228"
] | Cabazitaxel | Brentuximab vedotin | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
310,
24,
850
]
],
[
[
310,
24,
788
],
[
788,
24,
850
]
],
[
[
310,
63,
671
],
[
671,
24,
850
]
],
[
[
310,
24,
496
],
[
496,
63,... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Fluvas... |
DB00777 | DB04843 | 146 | 1,511 | [
"DDInter1537",
"DDInter1149"
] | Propiomazine | Mepenzolate | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
146,
24,
1511
]
],
[
[
146,
24,
1192
],
[
1192,
24,
1511
]
],
[
[
146,
63,
262
],
[
262,
24,
1511
]
],
[
[
146,
1,
1301
],
[
1301,
... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Clidiniu... |
DB00624 | DB09564 | 1,561 | 1,296 | [
"DDInter1775",
"DDInter930"
] | Testosterone | Insulin degludec | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1561,
24,
1296
]
],
[
[
1561,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1561,
63,
542
],
[
542,
24,
1296
]
],
[
[
1561,
40,
1336
],
[
1336... | [
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Testosterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Testosterone may cause a moderate interaction that could exacerbate diseases when taken with Levothyro... |
DB01059 | DB01268 | 956 | 1,151 | [
"DDInter1313",
"DDInter1731"
] | Norfloxacin | Sunitinib | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
956,
24,
1151
]
],
[
[
956,
6,
6799
],
[
6799,
45,
1151
]
],
[
[
956,
21,
28868
],
[
28868,
60,
1151
]
],
[
[
956,
62,
112
],
[
112,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7"
],
[
"CYP3A7",
"{u} (Gene) is bound by {v} (Compound)"... | Norfloxacin (Compound) binds CYP3A7 (Gene) and CYP3A7 (Gene) is bound by Sunitinib (Compound)
Norfloxacin (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Sunitinib (Compound)
Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and ... |
DB04868 | DB11757 | 478 | 960 | [
"DDInter1293",
"DDInter994"
] | Nilotinib | Istradefylline | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Moderate | 1 | [
[
[
478,
24,
960
]
],
[
[
478,
23,
1135
],
[
1135,
23,
960
]
],
[
[
478,
64,
77
],
[
77,
24,
960
]
],
[
[
478,
24,
1499
],
[
1499,
2... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Istradefylline"
]
],
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Nilotinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Istradefylline
Nilotinib may lead to a major life threatening interaction when taken with Idarubicin and Idarubicin may cause a mo... |
DB00794 | DB05294 | 759 | 1,069 | [
"DDInter1521",
"DDInter1917"
] | Primidone | Vandetanib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Moderate | 1 | [
[
[
759,
24,
1069
]
],
[
[
759,
63,
1195
],
[
1195,
40,
1069
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],
[
[
759,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
759,
21,
28883
],
[
28883,... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Primidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Primidone (Compound) causes Skin disorder (Side Effect) and Skin disor... |
DB00372 | DB01075 | 999 | 1,376 | [
"DDInter1793",
"DDInter569"
] | Thiethylperazine | Diphenhydramine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
999,
24,
1376
]
],
[
[
999,
24,
128
],
[
128,
24,
1376
]
],
[
[
999,
63,
1594
],
[
1594,
24,
1376
]
],
[
[
999,
25,
675
],
[
675,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbromphe... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when... |
DB00397 | DB00431 | 1,466 | 1,503 | [
"DDInter1458",
"DDInter1072"
] | Phenylpropanolamine | Lindane | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Moderate | 1 | [
[
[
1466,
24,
1503
]
],
[
[
1466,
21,
28921
],
[
28921,
60,
1503
]
],
[
[
1466,
25,
939
],
[
939,
63,
1503
]
],
[
[
1466,
24,
104
],
[
104... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lindane"
]
],
[
[
"Phenylpropanolamine",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side ... | Phenylpropanolamine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Lindane (Compound)
Phenylpropanolamine may lead to a major life threatening interaction when taken with Benzphetamine and Benzphetamine may cause a moderate interaction that could exacerbate diseases when taken with L... |
DB00321 | DB00637 | 21 | 1,557 | [
"DDInter78",
"DDInter128"
] | Amitriptyline | Astemizole | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
21,
24,
1557
]
],
[
[
21,
6,
8374
],
[
8374,
45,
1557
]
],
[
[
21,
7,
9650
],
[
9650,
46,
1557
]
],
[
[
21,
18,
2049
],
[
2049,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Amitriptyline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Astemizole (Compound)
Amitriptyline (Compound) upregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Astemizole (Compound)
Amitriptyline (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Astemizole (Compound)
A... |
DB00081 | DB00814 | 273 | 1,171 | [
"DDInter1838",
"DDInter1143"
] | Tositumomab | Meloxicam | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Major | 2 | [
[
[
273,
25,
1171
]
],
[
[
273,
25,
1027
],
[
1027,
40,
1171
]
],
[
[
273,
25,
936
],
[
936,
63,
1171
]
],
[
[
273,
64,
366
],
[
366,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meloxicam"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Piroxicam"
],
[
"Piroxicam",
"{u} (C... | Tositumomab may lead to a major life threatening interaction when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Cangrelor and Cangrelor may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00569 | DB10672 | 553 | 297 | [
"DDInter775",
"DDInter417"
] | Fondaparinux | Clove | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
553,
23,
297
]
],
[
[
553,
25,
235
],
[
235,
62,
297
]
],
[
[
553,
25,
578
],
[
578,
23,
297
]
],
[
[
553,
64,
366
],
[
366,
23,... | [
[
[
"Fondaparinux",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Fondaparinux",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Fondaparinux may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Fondaparinux may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a minor interaction ... |
DB00370 | DB11110 | 1,251 | 603 | [
"DDInter1230",
"DDInter1115"
] | Mirtazapine | Magnesium citrate | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1251,
24,
603
]
],
[
[
1251,
25,
57
],
[
57,
24,
603
]
],
[
[
1251,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1251,
24,
484
],
[
484,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Mirtazapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Mirtazapine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and H... |
DB09049 | DB12095 | 1,135 | 179 | [
"DDInter1261",
"DDInter1760"
] | Naloxegol | Telotristat ethyl | Naloxegol, for "PEGylated naloxol" is a peripherally-selective opioid antagonist developed by AstraZeneca. It was approved by the FDA in September 2014 and is indicated for the treatment of opioid-induced constipation (OIC) in adult patients with chronic non‑cancer pain. The advantage of naloxegol over the opioid antag... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
1135,
24,
179
]
],
[
[
1135,
62,
79
],
[
79,
24,
179
]
],
[
[
1135,
24,
214
],
[
214,
24,
179
]
],
[
[
1135,
64,
1593
],
[
1593,
... | [
[
[
"Naloxegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Naloxegol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sorafenib"
],
[
... | Naloxegol may cause a minor interaction that can limit clinical effects when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fos... |
DB01263 | DB14723 | 859 | 159 | [
"DDInter1494",
"DDInter1026"
] | Posaconazole | Larotrectinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
859,
25,
159
]
],
[
[
859,
24,
466
],
[
466,
23,
159
]
],
[
[
859,
25,
1135
],
[
1135,
23,
159
]
],
[
[
859,
24,
741
],
[
741,
2... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"D... | Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Posaconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may... |
DB09080 | DB12161 | 144 | 730 | [
"DDInter1331",
"DDInter512"
] | Olodaterol | Deutetrabenazine | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated . The presence of deuterium in deutetrabenazine increases the half-lives ... | Moderate | 1 | [
[
[
144,
24,
730
]
],
[
[
144,
63,
322
],
[
322,
24,
730
]
],
[
[
144,
24,
971
],
[
971,
24,
730
]
],
[
[
144,
24,
1619
],
[
1619,
6... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deutetrabenazine"
]
],
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Deutetrabenazine
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib an... |
DB00582 | DB11986 | 1,622 | 484 | [
"DDInter1946",
"DDInter648"
] | Voriconazole | Entrectinib | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
1622,
25,
484
]
],
[
[
1622,
23,
112
],
[
112,
23,
484
]
],
[
[
1622,
23,
466
],
[
466,
62,
484
]
],
[
[
1622,
25,
1135
],
[
1135,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Voriconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Voriconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide and... |
DB01045 | DB06626 | 463 | 263 | [
"DDInter1590",
"DDInter147"
] | Rifampicin | Axitinib | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
463,
25,
263
]
],
[
[
463,
63,
1215
],
[
1215,
23,
263
]
],
[
[
463,
24,
1384
],
[
1384,
62,
263
]
],
[
[
463,
24,
101
],
[
101,
... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Rifampicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
"Lansoprazo... | Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Rifampicin may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate and Magald... |
DB00363 | DB00444 | 695 | 63 | [
"DDInter419",
"DDInter1765"
] | Clozapine | Teniposide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Major | 2 | [
[
[
695,
25,
63
]
],
[
[
695,
6,
6017
],
[
6017,
45,
63
]
],
[
[
695,
18,
5527
],
[
5527,
57,
63
]
],
[
[
695,
25,
147
],
[
147,
62,... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teniposide"
]
],
[
[
"Clozapine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Teniposid... | Clozapine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Teniposide (Compound)
Clozapine (Compound) downregulates HAT1 (Gene) and HAT1 (Gene) is downregulated by Teniposide (Compound)
Clozapine may lead to a major life threatening interaction when taken with Vinblastine and Vinblastine may cause a minor i... |
DB01211 | DB13928 | 609 | 1,385 | [
"DDInter393",
"DDInter1660"
] | Clarithromycin | Semaglutide | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
609,
24,
1385
]
],
[
[
609,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
609,
24,
1399
],
[
1399,
63,
1385
]
],
[
[
609,
64,
839
],
[
839,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"... | Clarithromycin may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate and Lit... |
DB00603 | DB01432 | 303 | 857 | [
"DDInter1137",
"DDInter368"
] | Medroxyprogesterone acetate | Cholestyramine | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Cholestyramine or colestyramine is a bile acid sequestrant. Bile acid sequestrants are polymeric compounds which serve as ion exchange resins. Cholestyramine resin is quite hydrophilic, but insoluble in water. | Moderate | 1 | [
[
[
303,
24,
857
]
],
[
[
303,
24,
1411
],
[
1411,
24,
857
]
],
[
[
303,
40,
870
],
[
870,
24,
857
]
],
[
[
303,
63,
590
],
[
590,
2... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholestyramine"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Cholestyramine
Medroxyprogesterone acetate (Compound) resembles Fludrocortisone (Compound) and Fludrocor... |
DB00497 | DB01105 | 828 | 222 | [
"DDInter1366",
"DDInter1665"
] | Oxycodone | Sibutramine | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
828,
24,
222
]
],
[
[
828,
6,
8374
],
[
8374,
45,
222
]
],
[
[
828,
21,
29152
],
[
29152,
60,
222
]
],
[
[
828,
25,
384
],
[
384,
... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Oxycodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Oxycodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sibutramine (Compound)
Oxycodone (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Sibutramine (Compound)
Oxycodone may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a min... |
DB11613 | DB12332 | 1,519 | 1,619 | [
"DDInter1924",
"DDInter1626"
] | Velpatasvir | Rucaparib | Velpatasvir is a Direct-Acting Antiviral (DAA) medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1519,
24,
1619
]
],
[
[
1519,
62,
1135
],
[
1135,
23,
1619
]
],
[
[
1519,
63,
1362
],
[
1362,
24,
1619
]
],
[
[
1519,
24,
710
],
[
710... | [
[
[
"Velpatasvir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Velpatasvir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Velpatasvir may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Velpatasvir may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may ... |
DB01234 | DB09073 | 1,220 | 951 | [
"DDInter513",
"DDInter1379"
] | Dexamethasone | Palbociclib | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1220,
24,
951
]
],
[
[
1220,
25,
907
],
[
907,
62,
951
]
],
[
[
1220,
23,
271
],
[
271,
23,
951
]
],
[
[
1220,
63,
479
],
[
479,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doravirine"
],
[
"Dor... | Dexamethasone may lead to a major life threatening interaction when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegron may cau... |
DB08871 | DB08889 | 36 | 350 | [
"DDInter666",
"DDInter299"
] | Eribulin | Carfilzomib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Moderate | 1 | [
[
[
36,
24,
350
]
],
[
[
36,
63,
833
],
[
833,
1,
350
]
],
[
[
36,
24,
1270
],
[
1270,
63,
350
]
],
[
[
36,
25,
996
],
[
996,
63,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carfilzomib"
]
],
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lopinavir"
],
[
... | Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Lopinavir and Lopinavir (Compound) resembles Carfilzomib (Compound)
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein der... |
DB01097 | DB11627 | 1,377 | 1,367 | [
"DDInter1033",
"DDInter860"
] | Leflunomide | Hepatitis B Vaccine (Recombinant) | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
1377,
24,
1367
]
],
[
[
1377,
64,
1083
],
[
1083,
24,
1367
]
],
[
[
1377,
25,
1480
],
[
1480,
24,
1367
]
],
[
[
1377,
25,
119
],
[
119... | [
[
[
"Leflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluridine"
... | Leflunomide may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Leflunomide may lead to a major life threatening interaction when taken with Ixazomib and Ixazomib ... |
DB00601 | DB01124 | 453 | 1,411 | [
"DDInter1073",
"DDInter1828"
] | Linezolid | Tolbutamide | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
453,
24,
1411
]
],
[
[
453,
24,
959
],
[
959,
40,
1411
]
],
[
[
453,
63,
245
],
[
245,
40,
1411
]
],
[
[
453,
21,
28746
],
[
28746,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB00996 | DB09481 | 1,198 | 460 | [
"DDInter791",
"DDInter1113"
] | Gabapentin | Magnesium carbonate | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1198,
23,
460
]
],
[
[
1198,
24,
401
],
[
401,
23,
460
]
],
[
[
1198,
62,
752
],
[
752,
23,
460
]
],
[
[
1198,
24,
1487
],
[
1487,
... | [
[
[
"Gabapentin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Gabapentin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Gabapentin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Gabapentin may cause a minor interaction that can limit clinical effects when taken with Cimetidine a... |
DB01246 | DB13928 | 820 | 1,385 | [
"DDInter45",
"DDInter1660"
] | Alimemazine | Semaglutide | A phenothiazine derivative that is used as an antipruritic. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
820,
24,
1385
]
],
[
[
820,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
820,
24,
1399
],
[
1399,
63,
1385
]
],
[
[
820,
63,
359
],
[
359,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Alimemazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"Pasire... | Alimemazine may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate and Lithium c... |
DB00656 | DB00927 | 827 | 1,559 | [
"DDInter1851",
"DDInter712"
] | Trazodone | Famotidine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
827,
24,
1559
]
],
[
[
827,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
827,
24,
286
],
[
286,
62,
1559
]
],
[
[
827,
23,
112
],
[
112,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Trazodone",
"{u} (Compound) causes {v} (Side Effect)",
"Jaundice"
],
[
"Jaundice",
"{u} (Side Effect) is caused b... | Trazodone (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken ... |
DB00773 | DB09291 | 896 | 741 | [
"DDInter702",
"DDInter1615"
] | Etoposide | Rolapitant | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
896,
24,
741
]
],
[
[
896,
24,
159
],
[
159,
63,
741
]
],
[
[
896,
24,
1671
],
[
1671,
24,
741
]
],
[
[
896,
62,
147
],
[
147,
2... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and F... |
DB01105 | DB11166 | 222 | 18 | [
"DDInter1665",
"DDInter104"
] | Sibutramine | Antithrombin Alfa | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations. | Moderate | 1 | [
[
[
222,
24,
18
]
],
[
[
222,
63,
714
],
[
714,
24,
18
]
],
[
[
222,
25,
1039
],
[
1039,
24,
18
]
],
[
[
222,
64,
121
],
[
121,
24,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Antithrombin Alfa"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Antithrombin Alfa
Sibutramine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenflura... |
DB00046 | DB00286 | 1,179 | 380 | [
"DDInter940",
"DDInter439"
] | Insulin lispro | Conjugated estrogens | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Moderate | 1 | [
[
[
1179,
24,
380
]
],
[
[
1179,
24,
559
],
[
559,
1,
380
]
],
[
[
1179,
24,
35
],
[
35,
40,
380
]
],
[
[
1179,
24,
1021
],
[
1021,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conjugated estrogens"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estrone"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Estrone and Estrone (Compound) resembles Conjugated estrogens (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Conjugated... |
DB00761 | DB01142 | 1,621 | 1,264 | [
"DDInter1497",
"DDInter593"
] | Potassium chloride | Doxepin | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
1621,
25,
1264
]
],
[
[
1621,
64,
508
],
[
508,
24,
1264
]
],
[
[
1621,
25,
401
],
[
401,
24,
1264
]
],
[
[
1621,
25,
1405
],
[
1405,
... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promazine"
],
[
"Promazine",
... | Potassium chloride may lead to a major life threatening interaction when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Potassium chloride may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause ... |
DB00075 | DB11003 | 541 | 748 | [
"DDInter1250",
"DDInter100"
] | Muromonab | Anthrax vaccine | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
541,
24,
748
]
],
[
[
541,
25,
676
],
[
676,
63,
748
]
],
[
[
541,
24,
1683
],
[
1683,
24,
748
]
],
[
[
541,
64,
1057
],
[
1057,
... | [
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Muromonab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
"Upada... | Muromonab may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab m... |
DB08896 | DB11703 | 292 | 405 | [
"DDInter1576",
"DDInter9"
] | Regorafenib | Acalabrutinib | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
292,
25,
405
]
],
[
[
292,
63,
383
],
[
383,
24,
405
]
],
[
[
292,
25,
1598
],
[
1598,
63,
405
]
],
[
[
292,
24,
1427
],
[
1427,
... | [
[
[
"Regorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Regorafenib may lead to a major life threatening interaction when taken with Tazemetosta... |
DB00073 | DB00108 | 1,394 | 1,066 | [
"DDInter1608",
"DDInter1268"
] | Rituximab | Natalizumab | Rituximab is a genetically engineered chimeric murine/human monoclonal antibody directed against the CD20 antigen found on the surface of normal and malignant B lymphocytes. The antibody is an IgG1 kappa immunoglobulin containing murine light and heavy-chain variable region sequences and human constant region sequences... | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Major | 2 | [
[
[
1394,
25,
1066
]
],
[
[
1394,
23,
1114
],
[
1114,
62,
1066
]
],
[
[
1394,
24,
949
],
[
949,
63,
1066
]
],
[
[
1394,
25,
375
],
[
375,
... | [
[
[
"Rituximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Natalizumab"
]
],
[
[
"Rituximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sulfat... | Rituximab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Natalizumab
Rituximab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani tox... |
DB00450 | DB06691 | 78 | 849 | [
"DDInter603",
"DDInter1155"
] | Droperidol | Mepyramine | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
78,
24,
849
]
],
[
[
78,
63,
1594
],
[
1594,
24,
849
]
],
[
[
78,
24,
272
],
[
272,
24,
849
]
],
[
[
78,
1,
1300
],
[
1300,
24,
... | [
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Droperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and ... |
DB01128 | DB06207 | 918 | 910 | [
"DDInter204",
"DDInter1667"
] | Bicalutamide | Silodosin | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Silodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenocepto... | Moderate | 1 | [
[
[
918,
24,
910
]
],
[
[
918,
6,
8374
],
[
8374,
45,
910
]
],
[
[
918,
21,
28921
],
[
28921,
60,
910
]
],
[
[
918,
24,
1264
],
[
1264,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Silodosin"
]
],
[
[
"Bicalutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Bicalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Silodosin (Compound)
Bicalutamide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Silodosin (Compound)
Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Dox... |
DB00687 | DB01115 | 870 | 336 | [
"DDInter747",
"DDInter1291"
] | Fludrocortisone | Nifedipine | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
870,
24,
336
]
],
[
[
870,
63,
1428
],
[
1428,
1,
336
]
],
[
[
870,
63,
1081
],
[
1081,
40,
336
]
],
[
[
870,
24,
409
],
[
409,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isradipine"
]... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradipine (Compound) resembles Nifedipine (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Nicardipine and Nicardipine (Compound) resembles Nifedipine... |
DB00197 | DB06702 | 1,324 | 573 | [
"DDInter1881",
"DDInter731"
] | Troglitazone | Fesoterodine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
1324,
24,
573
]
],
[
[
1324,
24,
1424
],
[
1424,
24,
573
]
],
[
[
1324,
24,
351
],
[
351,
63,
573
]
],
[
[
1324,
23,
1101
],
[
1101,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
[... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Fesoterodine
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboci... |
DB00087 | DB00791 | 599 | 132 | [
"DDInter41",
"DDInter1902"
] | Alemtuzumab | Uracil mustard | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Moderate | 1 | [
[
[
599,
24,
132
]
],
[
[
599,
24,
970
],
[
970,
40,
132
]
],
[
[
599,
24,
1430
],
[
1430,
63,
132
]
],
[
[
599,
63,
1253
],
[
1253,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Uracil mustard"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil and Fluorouracil (Compound) resembles Uracil mustard (Compound)
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interact... |
DB00468 | DB11799 | 1,424 | 627 | [
"DDInter1557",
"DDInter205"
] | Quinine | Bictegravir | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Moderate | 1 | [
[
[
1424,
24,
627
]
],
[
[
1424,
24,
578
],
[
578,
24,
627
]
],
[
[
1424,
25,
478
],
[
478,
24,
627
]
],
[
[
1424,
63,
600
],
[
600,
... | [
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
]
],
[
[
"Quinine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"... | Quinine may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Quinine may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moder... |
DB00486 | DB00801 | 1,614 | 1,563 | [
"DDInter1253",
"DDInter850"
] | Nabilone | Halazepam | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Halazepam is a _benzodiazepine_ derivative drug exerting anxiolytic, anticonvulsant, sedative, a muscle relaxing effects.[A1212, A178114] It has been shown to be less toxic than chlordiazepoxide or diazepam. This drug is no longer marketed in the United States, and was withdrawn by _Schering_, its manufacturer, in 2009... | Moderate | 1 | [
[
[
1614,
24,
1563
]
],
[
[
1614,
24,
686
],
[
686,
1,
1563
]
],
[
[
1614,
63,
902
],
[
902,
40,
1563
]
],
[
[
1614,
63,
523
],
[
523,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halazepam"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxazepam"
],
[
"Ox... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Oxazepam and Oxazepam (Compound) resembles Halazepam (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Halazepam (Compound)
Nabilone may c... |
DB00963 | DB01362 | 1,263 | 497 | [
"DDInter241",
"DDInter960"
] | Bromfenac | Iohexol | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1263,
25,
497
]
],
[
[
1263,
21,
28719
],
[
28719,
60,
497
]
],
[
[
1263,
63,
891
],
[
891,
25,
497
]
],
[
[
1263,
1,
24
],
[
24,
... | [
[
[
"Bromfenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Bromfenac",
"{u} (Compound) causes {v} (Side Effect)",
"Pain"
],
[
"Pain",
"{u} (Side Effect) is caused by {v} (Compound)",
"... | Bromfenac (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Iohexol (Compound)
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may lead to a major life threatening interaction when taken with Iohexol
Bromfenac (Compound) rese... |
DB00323 | DB09054 | 1,062 | 384 | [
"DDInter1829",
"DDInter905"
] | Tolcapone | Idelalisib | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1062,
24,
384
]
],
[
[
1062,
63,
305
],
[
305,
24,
384
]
],
[
[
1062,
24,
322
],
[
322,
24,
384
]
],
[
[
1062,
40,
24
],
[
24,
2... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Tolcapone may cause a moderate interaction that could exacerbate diseases w... |
DB00902 | DB01381 | 104 | 958 | [
"DDInter1168",
"DDInter819"
] | Methdilazine | Ginkgo biloba | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
104,
24,
958
]
],
[
[
104,
63,
73
],
[
73,
24,
958
]
],
[
[
104,
25,
593
],
[
593,
24,
958
]
],
[
[
104,
24,
1528
],
[
1528,
24,... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Methdilazine may lead to a major life threatening interaction when taken with Bupropion and Bupropion may... |
DB00927 | DB06589 | 1,559 | 1,250 | [
"DDInter712",
"DDInter1400"
] | Famotidine | Pazopanib | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Major | 2 | [
[
[
1559,
25,
1250
]
],
[
[
1559,
7,
1948
],
[
1948,
57,
1250
]
],
[
[
1559,
21,
29203
],
[
29203,
60,
1250
]
],
[
[
1559,
23,
1247
],
[
1... | [
[
[
"Famotidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pazopanib"
]
],
[
[
"Famotidine",
"{u} (Compound) upregulates {v} (Gene)",
"IFNAR1"
],
[
"IFNAR1",
"{u} (Gene) is downregulated by {v} (Compound)",
... | Famotidine (Compound) upregulates IFNAR1 (Gene) and IFNAR1 (Gene) is downregulated by Pazopanib (Compound)
Famotidine (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Pazopanib (Compound)
Famotidine may cause a minor interaction tha... |
DB01403 | DB13928 | 9 | 1,385 | [
"DDInter1175",
"DDInter1660"
] | Methotrimeprazine | Semaglutide | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
9,
24,
1385
]
],
[
[
9,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
9,
63,
73
],
[
73,
24,
1385
]
],
[
[
9,
24,
1296
],
[
1296,
24,
... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Methotrimeprazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
... | Methotrimeprazine may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phe... |
DB00197 | DB00776 | 1,324 | 1,335 | [
"DDInter1881",
"DDInter1360"
] | Troglitazone | Oxcarbazepine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
1324,
24,
1335
]
],
[
[
1324,
24,
1605
],
[
1605,
1,
1335
]
],
[
[
1324,
24,
902
],
[
902,
40,
1335
]
],
[
[
1324,
24,
401
],
[
401,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Clobazam and Clobazam (Compound) resembles Oxcarbazepine (Comp... |
DB00327 | DB00405 | 421 | 128 | [
"DDInter890",
"DDInter517"
] | Hydromorphone | Dexbrompheniramine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
421,
24,
128
]
],
[
[
421,
24,
662
],
[
662,
63,
128
]
],
[
[
421,
64,
475
],
[
475,
24,
128
]
],
[
[
421,
25,
1053
],
[
1053,
6... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Hydromorphone may lead to a major life threatening interaction when taken with Morphine and Mor... |
DB01087 | DB08871 | 1,520 | 36 | [
"DDInter1520",
"DDInter666"
] | Primaquine | Eribulin | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1520,
24,
36
]
],
[
[
1520,
62,
1247
],
[
1247,
23,
36
]
],
[
[
1520,
24,
519
],
[
519,
24,
36
]
],
[
[
1520,
63,
563
],
[
563,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Primaquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Primaquine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Eribulin
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone an... |
DB00023 | DB10429 | 305 | 200 | [
"DDInter127",
"DDInter282"
] | Asparaginase Escherichia coli | Candida albicans | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Moderate | 1 | [
[
[
305,
24,
200
]
],
[
[
305,
24,
1683
],
[
1683,
24,
200
]
],
[
[
305,
25,
976
],
[
976,
24,
200
]
],
[
[
305,
24,
1019
],
[
1019,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Candida albicans"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Candida albicans
Asparaginase Escherichia coli may lead to a major life threatening interaction when t... |
DB11560 | DB11718 | 1,678 | 927 | [
"DDInter1038",
"DDInter640"
] | Lesinurad | Encorafenib | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1678,
24,
927
]
],
[
[
1678,
63,
112
],
[
112,
23,
927
]
],
[
[
1678,
63,
1491
],
[
1491,
24,
927
]
],
[
[
1678,
24,
484
],
[
484,
... | [
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Lesinurad",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Lesinurad may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mi... |
DB01036 | DB04868 | 211 | 478 | [
"DDInter1832",
"DDInter1293"
] | Tolterodine | Nilotinib | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
211,
24,
478
]
],
[
[
211,
6,
6017
],
[
6017,
45,
478
]
],
[
[
211,
21,
28963
],
[
28963,
60,
478
]
],
[
[
211,
24,
1040
],
[
1040,
... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Tolterodine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)"... | Tolterodine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Tolterodine (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafe... |
DB00277 | DB00877 | 1,031 | 629 | [
"DDInter1791",
"DDInter1678"
] | Theophylline | Sirolimus | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1031,
24,
629
]
],
[
[
1031,
6,
8374
],
[
8374,
45,
629
]
],
[
[
1031,
7,
5415
],
[
5415,
46,
629
]
],
[
[
1031,
6,
1778
],
[
1778,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Theophylline",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Theophylline (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sirolimus (Compound)
Theophylline (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is upregulated by Sirolimus (Compound)
Theophylline (Compound) binds HDAC2 (Gene) and HDAC2 (Gene) is downregulated by Sirolimus (Compound)
Theophylline (Com... |
DB06616 | DB11932 | 594 | 327 | [
"DDInter224",
"DDInter3"
] | Bosutinib | Abametapir (topical) | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
594,
24,
327
]
],
[
[
594,
24,
124
],
[
124,
63,
327
]
],
[
[
594,
25,
283
],
[
283,
63,
327
]
],
[
[
594,
63,
79
],
[
79,
24,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Bosutinib may ... |
DB00951 | DB04868 | 1,072 | 478 | [
"DDInter986",
"DDInter1293"
] | Isoniazid | Nilotinib | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1072,
24,
478
]
],
[
[
1072,
24,
1468
],
[
1468,
63,
478
]
],
[
[
1072,
6,
6017
],
[
6017,
45,
478
]
],
[
[
1072,
21,
29015
],
[
29015... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Isoniazid (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Isoniazid (Compound) cau... |
DB00860 | DB00951 | 891 | 1,072 | [
"DDInter1513",
"DDInter986"
] | Prednisolone | Isoniazid | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Minor | 0 | [
[
[
891,
23,
1072
]
],
[
[
891,
6,
8374
],
[
8374,
45,
1072
]
],
[
[
891,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
891,
1,
1486
],
[
1486,
... | [
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Isoniazid"
]
],
[
[
"Prednisolone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Prednisolone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isoniazid (Compound)
Prednisolone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Prednisolone (Compound) resembles Methylprednisolone (Compound) and Methyl
Prednisolone may cause a minor interact... |
DB00701 | DB00731 | 1,091 | 1,144 | [
"DDInter90",
"DDInter1269"
] | Amprenavir | Nateglinide | Amprenavir is a protease inhibitor used to treat HIV infection. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
1091,
24,
1144
]
],
[
[
1091,
63,
168
],
[
168,
24,
1144
]
],
[
[
1091,
6,
6017
],
[
6017,
45,
1144
]
],
[
[
1091,
21,
28787
],
[
2878... | [
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide
Amprenavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nateglinide (Compound)
Amprenavir (Comp... |
DB01365 | DB06704 | 280 | 247 | [
"DDInter1151",
"DDInter952"
] | Mephentermine | Iobenguane (I-131) | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Major | 2 | [
[
[
280,
37,
247
]
],
[
[
280,
40,
1161
],
[
1161,
25,
247
]
],
[
[
280,
25,
1629
],
[
1629,
64,
247
]
],
[
[
280,
40,
93
],
[
93,
3... | [
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Mephentermine",
"{u} (Compound) resembles {v} (Compound)",... | Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Mephentermine may lead to a major life threatening interaction when taken with Iobenguane
Mephentermine (Compound) resembles Selegiline (Compound) and Selegiline may lead to a major life threatening interaction ... |
DB00514 | DB00555 | 506 | 706 | [
"DDInter527",
"DDInter1020"
] | Dextromethorphan | Lamotrigine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | Moderate | 1 | [
[
[
506,
24,
706
]
],
[
[
506,
6,
4973
],
[
4973,
45,
706
]
],
[
[
506,
21,
28769
],
[
28769,
60,
706
]
],
[
[
506,
63,
530
],
[
530,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lamotrigine"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (... | Dextromethorphan (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lamotrigine (Compound)
Dextromethorphan (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Lamotrigine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases whe... |
DB01309 | DB08869 | 1,254 | 162 | [
"DDInter933",
"DDInter1773"
] | Insulin glulisine | Tesamorelin | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and... | Moderate | 1 | [
[
[
1254,
24,
162
]
],
[
[
1254,
63,
170
],
[
170,
24,
162
]
],
[
[
1254,
24,
1344
],
[
1344,
63,
162
]
],
[
[
1254,
24,
761
],
[
761,
... | [
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tesamorelin"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Tesamorelin
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Cana... |
DB00916 | DB11978 | 112 | 124 | [
"DDInter1202",
"DDInter822"
] | Metronidazole | Glasdegib | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Minor | 0 | [
[
[
112,
23,
124
]
],
[
[
112,
23,
1247
],
[
1247,
23,
124
]
],
[
[
112,
23,
1079
],
[
1079,
24,
124
]
],
[
[
112,
62,
79
],
[
79,
2... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glasdegib"
]
],
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Metronidazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin... |
DB00333 | DB08816 | 576 | 578 | [
"DDInter1166",
"DDInter1802"
] | Methadone | Ticagrelor | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
576,
24,
578
]
],
[
[
576,
6,
4973
],
[
4973,
45,
578
]
],
[
[
576,
21,
28762
],
[
28762,
60,
578
]
],
[
[
576,
25,
1011
],
[
1011,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Methadone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Methadone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Methadone may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a min... |
DB00889 | DB01149 | 1,133 | 851 | [
"DDInter840",
"DDInter1274"
] | Granisetron | Nefazodone | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Major | 2 | [
[
[
1133,
25,
851
]
],
[
[
1133,
63,
252
],
[
252,
40,
851
]
],
[
[
1133,
63,
1178
],
[
1178,
1,
851
]
],
[
[
1133,
24,
673
],
[
673,
... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[
"Hydroxy... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Nefazodone (Compound)
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Nefazodo... |
DB01246 | DB05316 | 820 | 749 | [
"DDInter45",
"DDInter1467"
] | Alimemazine | Pimavanserin | A phenothiazine derivative that is used as an antipruritic. | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Moderate | 1 | [
[
[
820,
24,
749
]
],
[
[
820,
62,
112
],
[
112,
23,
749
]
],
[
[
820,
74,
1264
],
[
1264,
24,
749
]
],
[
[
820,
24,
392
],
[
392,
2... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimavanserin"
]
],
[
[
"Alimemazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Alimemazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Alimemazine (Compound) resembles Doxepin (Compound) and Alimemazine may cause a moderate interaction that c... |
DB06595 | DB14975 | 1,491 | 988 | [
"DDInter1214",
"DDInter1949"
] | Midostaurin | Voxelotor | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
1491,
24,
988
]
],
[
[
1491,
63,
629
],
[
629,
24,
988
]
],
[
[
1491,
25,
985
],
[
985,
24,
988
]
],
[
[
1491,
24,
1362
],
[
1362,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Midostaurin may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause... |
DB00604 | DB06595 | 1,425 | 1,491 | [
"DDInter385",
"DDInter1214"
] | Cisapride | Midostaurin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
1425,
25,
1491
]
],
[
[
1425,
23,
112
],
[
112,
23,
1491
]
],
[
[
1425,
25,
888
],
[
888,
24,
1491
]
],
[
[
1425,
24,
1017
],
[
1017,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidaz... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Cisapride may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a... |
DB00069 | DB06273 | 367 | 980 | [
"DDInter946",
"DDInter1824"
] | Interferon alfacon-1 | Tocilizumab | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
367,
24,
980
]
],
[
[
367,
25,
139
],
[
139,
24,
980
]
],
[
[
367,
24,
309
],
[
309,
24,
980
]
],
[
[
367,
24,
110
],
[
110,
63,... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zidovudine"
],
... | Interferon alfacon-1 may lead to a major life threatening interaction when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and... |
DB00585 | DB01259 | 1,127 | 392 | [
"DDInter1309",
"DDInter1024"
] | Nizatidine | Lapatinib | A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1127,
24,
392
]
],
[
[
1127,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1127,
21,
28792
],
[
28792,
60,
392
]
],
[
[
1127,
25,
1406
],
[
1406... | [
[
[
"Nizatidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Nizatidine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Nizatidine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Nizatidine (Compound) causes Gastrointestinal disorder (Side Effect) and Gastrointestinal disorder (Side Effect) is caused by Lapatinib (Compound)
Nizatidine may lead to a major life threatening interaction when taken with Nerati... |
DB00443 | DB00586 | 251 | 1,512 | [
"DDInter195",
"DDInter537"
] | Betamethasone | Diclofenac | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Moderate | 1 | [
[
[
251,
24,
1512
]
],
[
[
251,
24,
1020
],
[
1020,
1,
1512
]
],
[
[
251,
24,
1263
],
[
1263,
63,
1512
]
],
[
[
251,
24,
1364
],
[
1364,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine (Compound) resembles Diclofenac (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Bromfenac and Bromfenac may cause a moderate interaction that cou... |
DB00206 | DB09564 | 1,245 | 1,296 | [
"DDInter1582",
"DDInter930"
] | Reserpine | Insulin degludec | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1245,
24,
1296
]
],
[
[
1245,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
1245,
63,
73
],
[
73,
24,
1296
]
],
[
[
1245,
40,
1340
],
[
1340,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and... |
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