drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01041 | DB14811 | 770 | 385 | [
"DDInter1789",
"DDInter979"
] | Thalidomide | Isatuximab | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Isatuximab (formerly SAR650984) is a humanized, IgG1-derived monoclonal antibody (mAb) produced from a Chinese hamster ovary (CHO) cell line.[L12099,A191799] Structurally, isatuximab is comprised of two identical immunoglobulin kappa light chains and two identical immunoglobulin gamma heavy chains. It is a cytolytic an... | Moderate | 1 | [
[
[
770,
24,
385
]
],
[
[
770,
24,
1362
],
[
1362,
24,
385
]
],
[
[
770,
64,
377
],
[
377,
24,
385
]
],
[
[
770,
25,
37
],
[
37,
24,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isatuximab"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Isatuximab
Thalidomide may lead to a major life threatening interaction when taken with Mitomycin and Mitomycin may cause a mo... |
DB00682 | DB12332 | 126 | 1,619 | [
"DDInter1951",
"DDInter1626"
] | Warfarin | Rucaparib | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
126,
24,
1619
]
],
[
[
126,
24,
222
],
[
222,
23,
1619
]
],
[
[
126,
35,
307
],
[
307,
23,
1619
]
],
[
[
126,
23,
271
],
[
271,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Warfarin (Compound) resembles Modafinil (Compound) and Warfarin may cause a moderate interaction that could exacerb... |
DB01259 | DB08827 | 392 | 990 | [
"DDInter1024",
"DDInter1085"
] | Lapatinib | Lomitapide | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
392,
25,
990
]
],
[
[
392,
64,
1080
],
[
1080,
1,
990
]
],
[
[
392,
6,
8374
],
[
8374,
45,
990
]
],
[
[
392,
21,
28903
],
[
28903,
... | [
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Lapatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",
"{u} (Co... | Lapatinib may lead to a major life threatening interaction when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Lapatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Lapatinib (Compound) causes Dry skin (Side Effect) and Dry skin (Side Effect) is ca... |
DB00215 | DB01069 | 1,230 | 401 | [
"DDInter388",
"DDInter1533"
] | Citalopram | Promethazine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Major | 2 | [
[
[
1230,
25,
401
]
],
[
[
1230,
25,
1264
],
[
1264,
63,
401
]
],
[
[
1230,
24,
649
],
[
649,
63,
401
]
],
[
[
1230,
24,
104
],
[
104,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promethazine"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
],
[
"Doxepin",
"{u} may c... | Citalopram may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a mo... |
DB00621 | DB01222 | 1,026 | 617 | [
"DDInter1357",
"DDInter246"
] | Oxandrolone | Budesonide | A synthetic hormone with anabolic and androgenic properties. | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
1026,
24,
617
]
],
[
[
1026,
63,
251
],
[
251,
1,
617
]
],
[
[
1026,
24,
1220
],
[
1220,
1,
617
]
],
[
[
1026,
18,
3616
],
[
3616,
... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
... | Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Budesoni... |
DB01234 | DB14409 | 1,220 | 1,129 | [
"DDInter513",
"DDInter867"
] | Dexamethasone | Human adenovirus e serotype 4 strain cl-68578 antigen | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1220,
24,
1129
]
],
[
[
1220,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1220,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
1220,
63,
134
],
[
134... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Dexamethasone may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Dexamethasone may cause a moderate interaction that could exacerbate diseases whe... |
DB05239 | DB13879 | 866 | 1,043 | [
"DDInter425",
"DDInter824"
] | Cobimetinib | Glecaprevir | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Glecaprevir is a direct acting antiviral agent and Hepatitis C virus (HCV) NS3/4A protease inhibitor that targets the the viral RNA replication. In combination with , glecaprevir is a useful therapy for patients who experienced therapeutic failure from other NS3/4A protease inhibitors. It demonstrates a high genetic ba... | Moderate | 1 | [
[
[
866,
24,
1043
]
],
[
[
866,
63,
353
],
[
353,
24,
1043
]
],
[
[
866,
24,
971
],
[
971,
24,
1043
]
],
[
[
866,
64,
1220
],
[
1220,
... | [
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glecaprevir"
]
],
[
[
"Cobimetinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
],
... | Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Glecaprevir
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib a... |
DB00397 | DB09045 | 1,466 | 52 | [
"DDInter1458",
"DDInter607"
] | Phenylpropanolamine | Dulaglutide | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
1466,
24,
52
]
],
[
[
1466,
24,
170
],
[
170,
23,
52
]
],
[
[
1466,
24,
280
],
[
280,
24,
52
]
],
[
[
1466,
64,
73
],
[
73,
24,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitaglip... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Me... |
DB00092 | DB09036 | 58 | 812 | [
"DDInter40",
"DDInter1668"
] | Alefacept | Siltuximab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
58,
24,
812
]
],
[
[
58,
23,
1193
],
[
1193,
62,
812
]
],
[
[
58,
23,
1461
],
[
1461,
23,
812
]
],
[
[
58,
24,
287
],
[
287,
63,... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Siltuximab
Alefacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin... |
DB01036 | DB01128 | 211 | 918 | [
"DDInter1832",
"DDInter204"
] | Tolterodine | Bicalutamide | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
211,
24,
918
]
],
[
[
211,
24,
129
],
[
129,
40,
918
]
],
[
[
211,
6,
8374
],
[
8374,
45,
918
]
],
[
[
211,
21,
28647
],
[
28647,
... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Tolterodine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Tolterodine (Compound) causes Urinary tract infection (S... |
DB00282 | DB01041 | 641 | 770 | [
"DDInter1383",
"DDInter1789"
] | Pamidronic acid | Thalidomide | Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid]. Pamidronic acid was first described in the literature in 1977. The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic ... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
641,
24,
770
]
],
[
[
641,
21,
28789
],
[
28789,
60,
770
]
],
[
[
641,
24,
1228
],
[
1228,
63,
770
]
],
[
[
641,
1,
1199
],
[
1199,
... | [
[
[
"Pamidronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Pamidronic acid",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness... | Pamidronic acid (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Pamidronic acid may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib and Lenvatinib may cause a moderate interaction that could exacerba... |
DB00014 | DB08882 | 521 | 1,281 | [
"DDInter839",
"DDInter1070"
] | Goserelin | Linagliptin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
521,
24,
1281
]
],
[
[
521,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
521,
21,
28966
],
[
28966,
60,
1281
]
],
[
[
521,
24,
1052
],
[
1052,... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
[
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Goserelin (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Linagliptin (Compou... |
DB09118 | DB11901 | 1,580 | 913 | [
"DDInter1711",
"DDInter107"
] | Stiripentol | Apalutamide | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1580,
25,
913
]
],
[
[
1580,
63,
608
],
[
608,
23,
913
]
],
[
[
1580,
63,
600
],
[
600,
24,
913
]
],
[
[
1580,
24,
1320
],
[
1320,
... | [
[
[
"Stiripentol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Stiripentol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocain... | Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Stiripentol may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flucon... |
DB00705 | DB15091 | 441 | 676 | [
"DDInter496",
"DDInter1901"
] | Delavirdine | Upadacitinib | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
441,
25,
676
]
],
[
[
441,
25,
283
],
[
283,
24,
676
]
],
[
[
441,
63,
600
],
[
600,
24,
676
]
],
[
[
441,
23,
1374
],
[
1374,
2... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{... | Delavirdine may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may ... |
DB00349 | DB00434 | 902 | 13 | [
"DDInter401",
"DDInter459"
] | Clobazam | Cyproheptadine | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
902,
24,
13
]
],
[
[
902,
24,
104
],
[
104,
63,
13
]
],
[
[
902,
40,
11305
],
[
11305,
1,
13
]
],
[
[
902,
21,
28905
],
[
28905,
... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Clobazam (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Cyproheptadine (... |
DB00703 | DB09133 | 997 | 1,527 | [
"DDInter1167",
"DDInter965"
] | Methazolamide | Iothalamic acid | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
997,
24,
1527
]
],
[
[
997,
63,
1648
],
[
1648,
24,
1527
]
],
[
[
997,
40,
471
],
[
471,
24,
1527
]
],
[
[
997,
63,
1287
],
[
1287,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Methazolamide (Compound) resembles Acetazolamide (Compound) and Acetazolamide may cause a moderate int... |
DB00563 | DB00774 | 663 | 1,577 | [
"DDInter1174",
"DDInter889"
] | Methotrexate | Hydroflumethiazide | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Moderate | 1 | [
[
[
663,
24,
1577
]
],
[
[
663,
24,
359
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[
359,
40,
1577
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[
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63,
323
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[
323,
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1577
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],
[
[
663,
24,
504
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[
504,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Bendroflumethiazide and Bendroflumethiazide (Comp... |
DB00673 | DB01174 | 723 | 697 | [
"DDInter112",
"DDInter1442"
] | Aprepitant | Phenobarbital | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
723,
24,
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]
],
[
[
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759
],
[
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[
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362,
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[
[
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[
536,
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... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound... |
DB01142 | DB04908 | 1,264 | 1,671 | [
"DDInter593",
"DDInter741"
] | Doxepin | Flibanserin | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
1264,
24,
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]
],
[
[
1264,
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[
741,
63,
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],
[
[
1264,
24,
830
],
[
830,
24,
1671
]
],
[
[
1264,
63,
1594
],
[
1594,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
[
"... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and Phenindam... |
DB00450 | DB14568 | 78 | 982 | [
"DDInter603",
"DDInter1000"
] | Droperidol | Ivosidenib | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
78,
25,
982
]
],
[
[
78,
23,
112
],
[
112,
23,
982
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[
[
78,
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543
],
[
543,
24,
982
]
],
[
[
78,
25,
1383
],
[
1383,
24,
... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lope... |
DB06372 | DB10583 | 259 | 949 | [
"DDInter1594",
"DDInter415"
] | Rilonacept | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
259,
24,
949
]
],
[
[
259,
63,
550
],
[
550,
24,
949
]
],
[
[
259,
24,
250
],
[
250,
24,
949
]
],
[
[
259,
64,
1377
],
[
1377,
2... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when t... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Rilonacept may cause a moderate interaction that could exace... |
DB00641 | DB11575 | 467 | 1,676 | [
"DDInter1675",
"DDInter841"
] | Simvastatin | Grazoprevir | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Grazoprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common i... | Major | 2 | [
[
[
467,
25,
1676
]
],
[
[
467,
24,
723
],
[
723,
24,
1676
]
],
[
[
467,
63,
1419
],
[
1419,
24,
1676
]
],
[
[
467,
24,
351
],
[
351,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Grazoprevir"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
"Aprepit... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Grazoprevir
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imati... |
DB00465 | DB09134 | 886 | 1,552 | [
"DDInter1010",
"DDInter966"
] | Ketorolac | Ioversol | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Major | 2 | [
[
[
886,
25,
1552
]
],
[
[
886,
25,
848
],
[
848,
25,
1552
]
],
[
[
886,
24,
1448
],
[
1448,
25,
1552
]
],
[
[
886,
1,
24
],
[
24,
2... | [
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ioversol"
]
],
[
[
"Ketorolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibuprofen"
],
[
"Ibuprofen",
"{u} may lea... | Ketorolac may lead to a major life threatening interaction when taken with Ibuprofen and Ibuprofen may lead to a major life threatening interaction when taken with Ioversol
Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin and Streptomycin may lead to a major life th... |
DB00220 | DB11760 | 798 | 119 | [
"DDInter1276",
"DDInter1742"
] | Nelfinavir | Talazoparib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
798,
24,
119
]
],
[
[
798,
25,
985
],
[
985,
24,
119
]
],
[
[
798,
25,
1406
],
[
1406,
63,
119
]
],
[
[
798,
1,
215
],
[
215,
24... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
],
[
"Osimerti... | Nelfinavir may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Nelfinavir may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause a moderate int... |
DB08912 | DB11757 | 1,040 | 960 | [
"DDInter462",
"DDInter994"
] | Dabrafenib | Istradefylline | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Moderate | 1 | [
[
[
1040,
24,
960
]
],
[
[
1040,
24,
1135
],
[
1135,
23,
960
]
],
[
[
1040,
24,
1499
],
[
1499,
24,
960
]
],
[
[
1040,
63,
134
],
[
134,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Istradefylline"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Istradefylline
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine and Nalde... |
DB00207 | DB01060 | 1,570 | 319 | [
"DDInter157",
"DDInter83"
] | Azithromycin | Amoxicillin | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Minor | 0 | [
[
[
1570,
23,
319
]
],
[
[
1570,
21,
28703
],
[
28703,
60,
319
]
],
[
[
1570,
24,
609
],
[
609,
62,
319
]
],
[
[
1570,
24,
1662
],
[
1662,... | [
[
[
"Azithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amoxicillin"
]
],
[
[
"Azithromycin",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is cau... | Azithromycin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Amoxicillin (Compound)
Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken wit... |
DB01259 | DB01403 | 392 | 9 | [
"DDInter1024",
"DDInter1175"
] | Lapatinib | Methotrimeprazine | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
392,
24,
9
]
],
[
[
392,
63,
1178
],
[
1178,
40,
9
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],
[
[
392,
63,
1164
],
[
1164,
1,
9
]
],
[
[
392,
64,
684
],
[
684,
40,
... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Met... |
DB00539 | DB01128 | 11 | 918 | [
"DDInter1837",
"DDInter204"
] | Toremifene | Bicalutamide | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Major | 2 | [
[
[
11,
25,
918
]
],
[
[
11,
25,
129
],
[
129,
40,
918
]
],
[
[
11,
6,
8374
],
[
8374,
45,
918
]
],
[
[
11,
7,
17537
],
[
17537,
46,... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Toremifene may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Toremifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Toremifene (Compound) upregulates USP6NL (Gene) and USP6NL (Gene) is upre... |
DB00662 | DB01100 | 717 | 1,568 | [
"DDInter1873",
"DDInter1470"
] | Trimethobenzamide | Pimozide | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
717,
24,
1568
]
],
[
[
717,
63,
78
],
[
78,
40,
1568
]
],
[
[
717,
21,
28766
],
[
28766,
60,
1568
]
],
[
[
717,
24,
649
],
[
649,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Droperidol"
... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Droperidol and Droperidol (Compound) resembles Pimozide (Compound)
Trimethobenzamide (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Pimozide (Compound)
Trimethobenzamide may cause a ... |
DB00331 | DB06663 | 1,645 | 1,154 | [
"DDInter1164",
"DDInter1398"
] | Metformin | Pasireotide | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
1645,
24,
1154
]
],
[
[
1645,
63,
966
],
[
966,
40,
1154
]
],
[
[
1645,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1645,
24,
959
],
[
959... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Metformin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Metformin may cause a moderate int... |
DB00543 | DB11837 | 87 | 1,297 | [
"DDInter82",
"DDInter1351"
] | Amoxapine | Osilodrostat | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
87,
24,
1297
]
],
[
[
87,
23,
112
],
[
112,
23,
1297
]
],
[
[
87,
25,
222
],
[
222,
23,
1297
]
],
[
[
87,
1,
623
],
[
623,
24,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Amoxapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Amoxapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Amoxapine may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may ca... |
DB00341 | DB01452 | 1,242 | 993 | [
"DDInter343",
"DDInter532"
] | Cetirizine | Diamorphine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Moderate | 1 | [
[
[
1242,
24,
993
]
],
[
[
1242,
63,
421
],
[
421,
40,
993
]
],
[
[
1242,
63,
475
],
[
475,
25,
993
]
],
[
[
1242,
24,
13
],
[
13,
2... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diamorphine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydromorphone"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Diamorphine (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may lead to a major life threatening int... |
DB06688 | DB09331 | 1,430 | 745 | [
"DDInter1677",
"DDInter478"
] | Sipuleucel-T | Daratumumab | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for the trea... | Moderate | 1 | [
[
[
1430,
24,
745
]
],
[
[
1430,
63,
139
],
[
139,
24,
745
]
],
[
[
1430,
24,
287
],
[
287,
63,
745
]
],
[
[
1430,
24,
1362
],
[
1362,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daratumumab"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
],
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Daratumumab
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumara... |
DB00407 | DB01105 | 202 | 222 | [
"DDInter115",
"DDInter1665"
] | Ardeparin | Sibutramine | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
202,
24,
222
]
],
[
[
202,
21,
29215
],
[
29215,
60,
222
]
],
[
[
202,
25,
1046
],
[
1046,
63,
222
]
],
[
[
202,
25,
1479
],
[
1479,
... | [
[
[
"Ardeparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Ardeparin",
"{u} (Compound) causes {v} (Side Effect)",
"Ecchymosis"
],
[
"Ecchymosis",
"{u} (Side Effect) is cau... | Ardeparin (Compound) causes Ecchymosis (Side Effect) and Ecchymosis (Side Effect) is caused by Sibutramine (Compound)
Ardeparin may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine
Ardep... |
DB00348 | DB06414 | 254 | 655 | [
"DDInter1300",
"DDInter703"
] | Nitisinone | Etravirine | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
254,
24,
655
]
],
[
[
254,
21,
28883
],
[
28883,
60,
655
]
],
[
[
254,
63,
1101
],
[
1101,
23,
655
]
],
[
[
254,
24,
1051
],
[
1051,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Skin disorder"
],
[
"Skin disorder",
"{u} (Side Effect)... | Nitisinone (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Etravirine (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with E... |
DB01263 | DB11986 | 859 | 484 | [
"DDInter1494",
"DDInter648"
] | Posaconazole | Entrectinib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
859,
25,
484
]
],
[
[
859,
62,
112
],
[
112,
23,
484
]
],
[
[
859,
24,
466
],
[
466,
62,
484
]
],
[
[
859,
25,
1135
],
[
1135,
2... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Posaconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Posaconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Posaconazole may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide a... |
DB00986 | DB01242 | 1,192 | 1,237 | [
"DDInter834",
"DDInter410"
] | Glycopyrronium | Clomipramine | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
1192,
24,
1237
]
],
[
[
1192,
63,
684
],
[
684,
1,
1237
]
],
[
[
1192,
24,
272
],
[
272,
24,
1237
]
],
[
[
1192,
63,
146
],
[
146,
... | [
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Glycopyrronium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
... | Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Thioridazine and Thioridazine (Compound) resembles Clomipramine (Compound)
Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moder... |
DB00443 | DB00722 | 251 | 743 | [
"DDInter195",
"DDInter1079"
] | Betamethasone | Lisinopril | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.[L8384,L8387,L8390] Lisinopril and [captopril] are the only ACEIs that are not prodrugs. It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldos... | Moderate | 1 | [
[
[
251,
24,
743
]
],
[
[
251,
24,
610
],
[
610,
40,
743
]
],
[
[
251,
24,
1638
],
[
1638,
1,
743
]
],
[
[
251,
6,
4973
],
[
4973,
4... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Lisinopril (Compound)
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Lisinopril (Co... |
DB01098 | DB08871 | 14 | 36 | [
"DDInter1622",
"DDInter666"
] | Rosuvastatin | Eribulin | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
14,
24,
36
]
],
[
[
14,
63,
1463
],
[
1463,
24,
36
]
],
[
[
14,
24,
973
],
[
973,
24,
36
]
],
[
[
14,
24,
1612
],
[
1612,
63,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lovastatin"
],
[
... | Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Lovastatin and Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Pacl... |
DB00497 | DB01110 | 828 | 86 | [
"DDInter1366",
"DDInter1209"
] | Oxycodone | Miconazole | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
828,
24,
86
]
],
[
[
828,
6,
8374
],
[
8374,
45,
86
]
],
[
[
828,
21,
29122
],
[
29122,
60,
86
]
],
[
[
828,
24,
222
],
[
222,
2... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Oxycodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Oxycodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Miconazole (Compound)
Oxycodone (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00352 | DB01097 | 482 | 1,377 | [
"DDInter1814",
"DDInter1033"
] | Tioguanine | Leflunomide | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
482,
25,
1377
]
],
[
[
482,
21,
28868
],
[
28868,
60,
1377
]
],
[
[
482,
63,
1461
],
[
1461,
23,
1377
]
],
[
[
482,
24,
949
],
[
949,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Stomatitis"
],
[
"Stomatitis",
"{u} (Side Effect) is caused by {v} (C... | Tioguanine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Leflunomide (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Leflunom... |
DB00685 | DB00860 | 1,299 | 891 | [
"DDInter1887",
"DDInter1513"
] | Trovafloxacin | Prednisolone | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Major | 2 | [
[
[
1299,
25,
891
]
],
[
[
1299,
64,
175
],
[
175,
40,
891
]
],
[
[
1299,
25,
167
],
[
167,
1,
891
]
],
[
[
1299,
64,
1573
],
[
1573,
... | [
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisolone"
]
],
[
[
"Trovafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone"... | Trovafloxacin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisolone (Compound)
Trovafloxacin may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Prednisolone (Compound)
Trovaf... |
DB00388 | DB04861 | 1,636 | 1,592 | [
"DDInter1453",
"DDInter1271"
] | Phenylephrine | Nebivolol | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1636,
24,
1592
]
],
[
[
1636,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
1636,
24,
1450
],
[
1450,
63,
1592
]
],
[
[
1636,
63,
1685
],
[
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Phenylephrine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is c... | Phenylephrine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00446 | DB11760 | 597 | 119 | [
"DDInter351",
"DDInter1742"
] | Chloramphenicol | Talazoparib | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
597,
24,
119
]
],
[
[
597,
63,
599
],
[
599,
24,
119
]
],
[
[
597,
24,
985
],
[
985,
24,
119
]
],
[
[
597,
25,
1478
],
[
1478,
2... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Osimerti... |
DB01005 | DB01206 | 995 | 37 | [
"DDInter894",
"DDInter1086"
] | Hydroxyurea | Lomustine | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | An alkylating agent of value against both hematologic malignancies and solid tumors. | Moderate | 1 | [
[
[
995,
24,
37
]
],
[
[
995,
5,
11613
],
[
11613,
44,
37
]
],
[
[
995,
6,
12523
],
[
12523,
45,
37
]
],
[
[
995,
21,
28722
],
[
28722,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine"
]
],
[
[
"Hydroxyurea",
"{u} (Compound) treats {v} (Disease)",
"brain cancer"
],
[
"brain cancer",
"{u} (Disease) is treat... | Hydroxyurea (Compound) treats brain cancer (Disease) and brain cancer (Disease) is treated by Lomustine (Compound)
Hydroxyurea (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Lomustine (Compound)
Hydroxyurea (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Lomustine (Compound)
H... |
DB00831 | DB01168 | 1,178 | 1,053 | [
"DDInter1866",
"DDInter1526"
] | Trifluoperazine | Procarbazine | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
1178,
24,
1053
]
],
[
[
1178,
6,
16392
],
[
16392,
45,
1053
]
],
[
[
1178,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
1178,
24,
480
],
[
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Trifluoperazine",
"{u} (Compound) binds {v} (Gene)",
"XDH"
],
[
"XDH",
"{u} (Gene) is bound by {v} (Compo... | Trifluoperazine (Compound) binds XDH (Gene) and XDH (Gene) is bound by Procarbazine (Compound)
Trifluoperazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Formoter... |
DB00727 | DB00986 | 685 | 1,192 | [
"DDInter1304",
"DDInter834"
] | Nitroglycerin | Glycopyrronium | Nitroglycerin, also known as glyceryl trinitrate, is an organic nitrate and a vasodilating agent that was first discovered in 1847. Originally used to dynamite, its antianginal effects were identified in the late 1860s after it produced headaches in factory workers while workers with angina pectoris or heart failure ex... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Minor | 0 | [
[
[
685,
23,
1192
]
],
[
[
685,
23,
1511
],
[
1511,
63,
1192
]
],
[
[
685,
23,
262
],
[
262,
24,
1192
]
],
[
[
685,
21,
29231
],
[
29231,
... | [
[
[
"Nitroglycerin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Nitroglycerin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mepenzolate"
],
... | Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Nitroglycerin may cause a minor interaction that can limit clinical effects when taken with Clidinium and... |
DB00348 | DB11986 | 254 | 484 | [
"DDInter1300",
"DDInter648"
] | Nitisinone | Entrectinib | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
254,
24,
484
]
],
[
[
254,
24,
1247
],
[
1247,
23,
484
]
],
[
[
254,
24,
998
],
[
998,
24,
484
]
],
[
[
254,
24,
159
],
[
159,
6... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],
... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Phenylbuta... |
DB00736 | DB11901 | 660 | 913 | [
"DDInter676",
"DDInter107"
] | Esomeprazole | Apalutamide | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
660,
24,
913
]
],
[
[
660,
24,
279
],
[
279,
24,
913
]
],
[
[
660,
63,
600
],
[
600,
24,
913
]
],
[
[
660,
23,
609
],
[
609,
24,... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
],
... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB01024 | DB01044 | 1,096 | 246 | [
"DDInter1252",
"DDInter809"
] | Mycophenolic acid | Gatifloxacin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Moderate | 1 | [
[
[
1096,
24,
246
]
],
[
[
1096,
63,
739
],
[
739,
1,
246
]
],
[
[
1096,
24,
945
],
[
945,
40,
246
]
],
[
[
1096,
63,
1467
],
[
1467,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxaci... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gatifloxacin (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resemble... |
DB00218 | DB09054 | 1,176 | 384 | [
"DDInter1247",
"DDInter905"
] | Moxifloxacin | Idelalisib | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1176,
24,
384
]
],
[
[
1176,
25,
1618
],
[
1618,
24,
384
]
],
[
[
1176,
23,
328
],
[
328,
24,
384
]
],
[
[
1176,
63,
305
],
[
305,
... | [
[
[
"Moxifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabo... | Moxifloxacin may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Mercaptopurine and Mercaptopur... |
DB00877 | DB06655 | 629 | 5 | [
"DDInter1678",
"DDInter1077"
] | Sirolimus | Liraglutide | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
629,
24,
5
]
],
[
[
629,
63,
743
],
[
743,
23,
5
]
],
[
[
629,
24,
700
],
[
700,
23,
5
]
],
[
[
629,
25,
915
],
[
915,
24,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisinopril"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Lisinopril and Lisinopril may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvas... |
DB00087 | DB15965 | 599 | 1,330 | [
"DDInter41",
"DDInter1270"
] | Alemtuzumab | Naxitamab | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
599,
24,
1330
]
],
[
[
599,
24,
1532
],
[
1532,
24,
1330
]
],
[
[
599,
63,
1184
],
[
1184,
24,
1330
]
],
[
[
599,
24,
375
],
[
375,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinr... |
DB00202 | DB00681 | 190 | 1,287 | [
"DDInter1716",
"DDInter85"
] | Succinylcholine | Amphotericin B | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Moderate | 1 | [
[
[
190,
24,
1287
]
],
[
[
190,
21,
28841
],
[
28841,
60,
1287
]
],
[
[
190,
24,
450
],
[
450,
24,
1287
]
],
[
[
190,
25,
1132
],
[
1132,
... | [
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
]
],
[
[
"Succinylcholine",
"{u} (Compound) causes {v} (Side Effect)",
"Bronchospasm"
],
[
"Bronchospasm",
"{u} (... | Succinylcholine (Compound) causes Bronchospasm (Side Effect) and Bronchospasm (Side Effect) is caused by Amphotericin B (Compound)
Succinylcholine may cause a moderate interaction that could exacerbate diseases when taken with Cyclophosphamide and Cyclophosphamide may cause a moderate interaction that could exacerbate ... |
DB01124 | DB08899 | 1,411 | 129 | [
"DDInter1828",
"DDInter649"
] | Tolbutamide | Enzalutamide | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1411,
24,
129
]
],
[
[
1411,
6,
6017
],
[
6017,
45,
129
]
],
[
[
1411,
21,
28703
],
[
28703,
60,
129
]
],
[
[
1411,
63,
1247
],
[
1247... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Tolbutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compoun... | Tolbutamide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Enzalutamide (Compound)
Tolbutamide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazo... |
DB01030 | DB06168 | 869 | 1,531 | [
"DDInter1835",
"DDInter281"
] | Topotecan | Canakinumab | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
869,
24,
1531
]
],
[
[
869,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
869,
63,
377
],
[
377,
24,
1531
]
],
[
[
869,
24,
1270
],
[
1270,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Mitomycin and Mitomycin ma... |
DB00365 | DB09322 | 839 | 1,114 | [
"DDInter842",
"DDInter1966"
] | Grepafloxacin | Zinc sulfate | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Zinc sulfate is the inorganic compound with the formula ZnSO4 and historically known as "white vitriol". It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system. | Moderate | 1 | [
[
[
839,
24,
1114
]
],
[
[
839,
25,
251
],
[
251,
23,
1114
]
],
[
[
839,
23,
1307
],
[
1307,
23,
1114
]
],
[
[
839,
24,
617
],
[
617,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zinc sulfate"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betamethasone"
],
[
... | Grepafloxacin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate
Grepafloxacin may cause a minor interaction that can limit clinical effects when taken with Melphalan and Melphalan ma... |
DB00934 | DB01259 | 413 | 392 | [
"DDInter1124",
"DDInter1024"
] | Maprotiline | Lapatinib | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
413,
24,
392
]
],
[
[
413,
6,
4973
],
[
4973,
45,
392
]
],
[
[
413,
18,
10375
],
[
10375,
57,
392
]
],
[
[
413,
21,
29429
],
[
29429,
... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Maprotiline",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Maprotiline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Maprotiline (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Lapatinib (Compound)
Maprotiline (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Lapatinib (... |
DB00691 | DB01225 | 1,058 | 500 | [
"DDInter1237",
"DDInter645"
] | Moexipril | Enoxaparin | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Moderate | 1 | [
[
[
1058,
24,
500
]
],
[
[
1058,
1,
664
],
[
664,
24,
500
]
],
[
[
1058,
40,
743
],
[
743,
24,
500
]
],
[
[
1058,
63,
305
],
[
305,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxaparin"
]
],
[
[
"Moexipril",
"{u} (Compound) resembles {v} (Compound)",
"Perindopril"
],
[
"Perindopril",
"{u} may cause a moderat... | Moexipril (Compound) resembles Perindopril (Compound) and Perindopril may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Moexipril (Compound) resembles Lisinopril (Compound) and Lisinopril may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
... |
DB00106 | DB13139 | 618 | 1,032 | [
"DDInter4",
"DDInter1063"
] | Abarelix | Levosalbutamol | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
618,
24,
1032
]
],
[
[
618,
25,
1618
],
[
1618,
24,
1032
]
],
[
[
618,
24,
124
],
[
124,
24,
1032
]
],
[
[
618,
25,
982
],
[
982,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabozant... | Abarelix may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may caus... |
DB00703 | DB08907 | 997 | 1,344 | [
"DDInter1167",
"DDInter280"
] | Methazolamide | Canagliflozin | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
997,
24,
1344
]
],
[
[
997,
24,
549
],
[
549,
1,
1344
]
],
[
[
997,
6,
8374
],
[
8374,
45,
1344
]
],
[
[
997,
21,
28680
],
[
28680,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
... | Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Methazolamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Canagliflozin (Compound)
Methazolamide (Compound) causes Rash (Side Effec... |
DB00364 | DB09104 | 417 | 286 | [
"DDInter1717",
"DDInter1118"
] | Sucralfate | Magnesium hydroxide | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
417,
24,
286
]
],
[
[
417,
24,
1482
],
[
1482,
23,
286
]
],
[
[
417,
23,
820
],
[
820,
23,
286
]
],
[
[
417,
62,
88
],
[
88,
23,... | [
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],
... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Sucralfate may cause a minor interaction that can limit clinical effects when taken with Alimemazine and Al... |
DB01200 | DB01612 | 469 | 1,637 | [
"DDInter243",
"DDInter92"
] | Bromocriptine | Amyl Nitrite | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
469,
24,
1637
]
],
[
[
469,
63,
475
],
[
475,
24,
1637
]
],
[
[
469,
24,
820
],
[
820,
24,
1637
]
],
[
[
469,
24,
407
],
[
407,
... | [
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
... | Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and A... |
DB00813 | DB06791 | 704 | 1,446 | [
"DDInter722",
"DDInter1021"
] | Fentanyl | Lanreotide | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome. This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. Lanreotide is manufactured ... | Moderate | 1 | [
[
[
704,
24,
1446
]
],
[
[
704,
1,
371
],
[
371,
24,
1446
]
],
[
[
704,
25,
1017
],
[
1017,
63,
1446
]
],
[
[
704,
24,
159
],
[
159,
... | [
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanreotide"
]
],
[
[
"Fentanyl",
"{u} (Compound) resembles {v} (Compound)",
"Propafenone"
],
[
"Propafenone",
"{u} may cause a moderate ... | Fentanyl (Compound) resembles Propafenone (Compound) and Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide
Fentanyl may lead to a major life threatening interaction when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate disea... |
DB00280 | DB09272 | 494 | 412 | [
"DDInter575",
"DDInter632"
] | Disopyramide | Eluxadoline | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
494,
24,
412
]
],
[
[
494,
35,
1594
],
[
1594,
24,
412
]
],
[
[
494,
24,
543
],
[
543,
24,
412
]
],
[
[
494,
25,
1374
],
[
1374,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Disopyramide",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when ta... | Disopyramide (Compound) resembles Doxylamine (Compound) and Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Disopyramide may cause a moderate interaction tha... |
DB00679 | DB01177 | 684 | 77 | [
"DDInter1796",
"DDInter904"
] | Thioridazine | Idarubicin | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
684,
25,
77
]
],
[
[
684,
6,
6017
],
[
6017,
45,
77
]
],
[
[
684,
18,
10663
],
[
10663,
46,
77
]
],
[
[
684,
7,
4145
],
[
4145,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
"Ida... | Thioridazine (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Idarubicin (Compound)
Thioridazine (Compound) downregulates MEA1 (Gene) and MEA1 (Gene) is upregulated by Idarubicin (Compound)
Thioridazine (Compound) upregulates HDAC5 (Gene) and HDAC5 (Gene) is upregulated by Idarubicin (Compound)
Thioridazine... |
DB01030 | DB11796 | 869 | 1,612 | [
"DDInter1835",
"DDInter786"
] | Topotecan | Fostemsavir | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
869,
24,
1612
]
],
[
[
869,
24,
1476
],
[
1476,
62,
1612
]
],
[
[
869,
63,
1101
],
[
1101,
23,
1612
]
],
[
[
869,
63,
51
],
[
51,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexaroten... |
DB00242 | DB00551 | 1,064 | 1,660 | [
"DDInter392",
"DDInter17"
] | Cladribine | Acetohydroxamic acid | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics... | Major | 2 | [
[
[
1064,
25,
1660
]
],
[
[
1064,
25,
995
],
[
995,
1,
1660
]
],
[
[
1064,
21,
28769
],
[
28769,
60,
1660
]
],
[
[
1064,
25,
1683
],
[
168... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetohydroxamic acid"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxyurea"
],
[
"Hydroxyurea",
... | Cladribine may lead to a major life threatening interaction when taken with Hydroxyurea and Hydroxyurea (Compound) resembles Acetohydroxamic acid (Compound)
Cladribine (Compound) causes Feeling abnormal (Side Effect) and Feeling abnormal (Side Effect) is caused by Acetohydroxamic acid (Compound)
Cladribine may lead to ... |
DB08901 | DB09048 | 1,468 | 555 | [
"DDInter1492",
"DDInter1284"
] | Ponatinib | Netupitant | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
1468,
24,
555
]
],
[
[
1468,
64,
1101
],
[
1101,
23,
555
]
],
[
[
1468,
25,
283
],
[
283,
62,
555
]
],
[
[
1468,
24,
384
],
[
384,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Ponatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",... | Ponatinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Ponatinib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor interaction... |
DB00827 | DB09104 | 646 | 286 | [
"DDInter383",
"DDInter1118"
] | Cinoxacin | Magnesium hydroxide | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
646,
24,
286
]
],
[
[
646,
23,
60
],
[
60,
23,
286
]
],
[
[
646,
24,
848
],
[
848,
23,
286
]
],
[
[
646,
24,
1283
],
[
1283,
24,... | [
[
[
"Cinoxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Cinoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capecitabine"
],
... | Cinoxacin may cause a minor interaction that can limit clinical effects when taken with Capecitabine and Capecitabine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Cinoxacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and ... |
DB00701 | DB11837 | 1,091 | 1,297 | [
"DDInter90",
"DDInter1351"
] | Amprenavir | Osilodrostat | Amprenavir is a protease inhibitor used to treat HIV infection. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1091,
25,
1297
]
],
[
[
1091,
25,
1135
],
[
1135,
23,
1297
]
],
[
[
1091,
23,
466
],
[
466,
62,
1297
]
],
[
[
1091,
23,
222
],
[
222,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Amprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Amprenavir may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause ... |
DB01059 | DB11110 | 956 | 603 | [
"DDInter1313",
"DDInter1115"
] | Norfloxacin | Magnesium citrate | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
956,
24,
603
]
],
[
[
956,
25,
57
],
[
57,
24,
603
]
],
[
[
956,
40,
246
],
[
246,
24,
603
]
],
[
[
956,
24,
1616
],
[
1616,
24,... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Norfloxacin may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Norfloxacin (Compound) resembles Gatifloxacin (Compound) and Gatifloxacin may cause a moderate interaction ... |
DB11718 | DB14568 | 927 | 982 | [
"DDInter640",
"DDInter1000"
] | Encorafenib | Ivosidenib | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
927,
25,
982
]
],
[
[
927,
62,
112
],
[
112,
23,
982
]
],
[
[
927,
63,
1101
],
[
1101,
23,
982
]
],
[
[
927,
63,
1081
],
[
1081,
... | [
[
[
"Encorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Encorafenib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Encorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Be... |
DB09078 | DB09082 | 1,228 | 659 | [
"DDInter1036",
"DDInter1934"
] | Lenvatinib | Vilanterol | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1228,
24,
659
]
],
[
[
1228,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1228,
24,
927
],
[
927,
63,
659
]
],
[
[
1228,
64,
1069
],
[
1069,
... | [
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Lenvatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
[
... | Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Lenvatinib may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and E... |
DB00981 | DB01122 | 1,528 | 158 | [
"DDInter1462",
"DDInter61"
] | Physostigmine | Ambenonium | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. | Moderate | 1 | [
[
[
1528,
24,
158
]
],
[
[
1528,
6,
10558
],
[
10558,
45,
158
]
],
[
[
1528,
63,
352
],
[
352,
24,
158
]
],
[
[
1528,
24,
1476
],
[
1476,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ambenonium"
]
],
[
[
"Physostigmine",
"{u} (Compound) binds {v} (Gene)",
"BCHE"
],
[
"BCHE",
"{u} (Gene) is bound by {v} (Compound)... | Physostigmine (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Ambenonium (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Ambenonium
Physostigmine may ca... |
DB01140 | DB09268 | 1,392 | 1,662 | [
"DDInter310",
"DDInter1464"
] | Cefadroxil | Picosulfuric acid | Long-acting, broad-spectrum, water-soluble, cephalexin derivative. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1392,
24,
1662
]
],
[
[
1392,
63,
597
],
[
597,
24,
1662
]
],
[
[
1392,
1,
319
],
[
319,
24,
1662
]
],
[
[
1392,
40,
1124
],
[
1124,
... | [
[
[
"Cefadroxil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Cefadroxil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
... | Cefadroxil may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Cefadroxil (Compound) resembles Amoxicillin (Compound) and Amoxicillin may cause a moderate int... |
DB04953 | DB11110 | 495 | 603 | [
"DDInter708",
"DDInter1115"
] | Ezogabine | Magnesium citrate | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
495,
24,
603
]
],
[
[
495,
64,
57
],
[
57,
24,
603
]
],
[
[
495,
24,
1616
],
[
1616,
24,
603
]
],
[
[
495,
63,
1151
],
[
1151,
2... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Ezogabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Ezogabine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and Histr... |
DB00029 | DB01225 | 25 | 500 | [
"DDInter99",
"DDInter645"
] | Anistreplase | Enoxaparin | Human tissue plasminogen activator, purified, glycosylated, 527 residues purified from CHO cells. Eminase is a lyophilized (freeze-dried) formulation of anistreplase, the p-anisoyl derivative of the primary Lys-plasminogen-streptokinase activator complex (a complex of Lys-plasminogen and streptokinase). A p-anisoyl gro... | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Major | 2 | [
[
[
25,
25,
500
]
],
[
[
25,
23,
1631
],
[
1631,
62,
500
]
],
[
[
25,
24,
1004
],
[
1004,
63,
500
]
],
[
[
25,
24,
1230
],
[
1230,
2... | [
[
[
"Anistreplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
]
],
[
[
"Anistreplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
],
[
"Turmeric",... | Anistreplase may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a minor interaction that can limit clinical effects when taken with Enoxaparin
Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phe... |
DB01238 | DB06655 | 673 | 5 | [
"DDInter118",
"DDInter1077"
] | Aripiprazole | Liraglutide | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
673,
24,
5
]
],
[
[
673,
63,
353
],
[
353,
23,
5
]
],
[
[
673,
63,
245
],
[
245,
24,
5
]
],
[
[
673,
40,
1630
],
[
1630,
24,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
],
... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride an... |
DB00295 | DB01174 | 475 | 697 | [
"DDInter1244",
"DDInter1442"
] | Morphine | Phenobarbital | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Major | 2 | [
[
[
475,
25,
697
]
],
[
[
475,
25,
759
],
[
759,
1,
697
]
],
[
[
475,
63,
362
],
[
362,
1,
697
]
],
[
[
475,
25,
536
],
[
536,
40,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenobarbital"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Primidone"
],
[
"Primidone",
"{u} (Com... | Morphine may lead to a major life threatening interaction when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compound)
Morphine may lead... |
DB00220 | DB11901 | 798 | 913 | [
"DDInter1276",
"DDInter107"
] | Nelfinavir | Apalutamide | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
798,
24,
913
]
],
[
[
798,
24,
608
],
[
608,
23,
913
]
],
[
[
798,
63,
600
],
[
600,
24,
913
]
],
[
[
798,
24,
303
],
[
303,
24,... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconaz... |
DB00041 | DB06204 | 1,648 | 768 | [
"DDInter38",
"DDInter1746"
] | Aldesleukin | Tapentadol | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Moderate | 1 | [
[
[
1648,
24,
768
]
],
[
[
1648,
24,
1383
],
[
1383,
63,
768
]
],
[
[
1648,
24,
1532
],
[
1532,
24,
768
]
],
[
[
1648,
25,
1259
],
[
1259,... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tapentadol"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
],
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate and Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Tapentadol
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide ... |
DB00197 | DB00288 | 1,324 | 1,103 | [
"DDInter1881",
"DDInter63"
] | Troglitazone | Amcinonide | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Amcinonide is a corticosteroid. | Minor | 0 | [
[
[
1324,
23,
1103
]
],
[
[
1324,
24,
175
],
[
175,
40,
1103
]
],
[
[
1324,
24,
870
],
[
870,
1,
1103
]
],
[
[
1324,
24,
1296
],
[
1296,
... | [
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Amcinonide (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Am... |
DB00637 | DB01236 | 1,557 | 679 | [
"DDInter128",
"DDInter1664"
] | Astemizole | Sevoflurane | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Moderate | 1 | [
[
[
1557,
24,
679
]
],
[
[
1557,
63,
1262
],
[
1262,
40,
679
]
],
[
[
1557,
6,
8374
],
[
8374,
45,
679
]
],
[
[
1557,
23,
112
],
[
112,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevoflurane"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perflutren"
],
[
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) resembles Sevoflurane (Compound)
Astemizole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sevoflurane (Compound)
Astemizole may cause a minor interaction that can limit clinical... |
DB00976 | DB09078 | 1,056 | 1,228 | [
"DDInter1758",
"DDInter1036"
] | Telithromycin | Lenvatinib | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
1056,
24,
1228
]
],
[
[
1056,
62,
112
],
[
112,
23,
1228
]
],
[
[
1056,
35,
609
],
[
609,
24,
1228
]
],
[
[
1056,
24,
1264
],
[
1264,
... | [
[
[
"Telithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Telithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Telithromycin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Telithromycin (Compound) resembles Clarithromycin (Compound) and Telithromycin may cause a moderate interac... |
DB00087 | DB15762 | 599 | 725 | [
"DDInter41",
"DDInter1644"
] | Alemtuzumab | Satralizumab | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Satralizumab is a recombinant humanized monoclonal antibody targeted against human interleukin-6 (IL-6) receptors, similar to [tocilizumab], which is produced in Chinese hamster ovary cells and based on an IgG2 framework. Satralizumab is used in the treatment of neuromyelitis optica spectrum disorder (NMOSD), a rare au... | Moderate | 1 | [
[
[
599,
24,
725
]
],
[
[
599,
24,
1362
],
[
1362,
24,
725
]
],
[
[
599,
63,
305
],
[
305,
24,
725
]
],
[
[
599,
25,
1066
],
[
1066,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escheric... |
DB00470 | DB00679 | 530 | 684 | [
"DDInter601",
"DDInter1796"
] | Dronabinol | Thioridazine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Moderate | 1 | [
[
[
530,
24,
684
]
],
[
[
530,
24,
1237
],
[
1237,
40,
684
]
],
[
[
530,
24,
216
],
[
216,
1,
684
]
],
[
[
530,
63,
508
],
[
508,
1,... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thioridazine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Thioridazine (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Thiorida... |
DB00544 | DB01033 | 970 | 328 | [
"DDInter757",
"DDInter1156"
] | Fluorouracil | Mercaptopurine | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Moderate | 1 | [
[
[
970,
24,
328
]
],
[
[
970,
6,
3300
],
[
3300,
45,
328
]
],
[
[
970,
21,
28681
],
[
28681,
60,
328
]
],
[
[
970,
23,
1299
],
[
1299,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
]
],
[
[
"Fluorouracil",
"{u} (Compound) binds {v} (Gene)",
"PPAT"
],
[
"PPAT",
"{u} (Gene) is bound by {v} (Compoun... | Fluorouracil (Compound) binds PPAT (Gene) and PPAT (Gene) is bound by Mercaptopurine (Compound)
Fluorouracil (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Mercaptopurine (Compound)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken wi... |
DB00985 | DB01246 | 1,443 | 820 | [
"DDInter562",
"DDInter45"
] | Dimenhydrinate | Alimemazine | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1443,
24,
820
]
],
[
[
1443,
40,
358
],
[
358,
24,
820
]
],
[
[
1443,
63,
104
],
[
104,
40,
820
]
],
[
[
1443,
24,
401
],
[
401,
... | [
[
[
"Dimenhydrinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Dimenhydrinate",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{u} may ca... | Dimenhydrinate (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Dimenhydrinate may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alime... |
DB00182 | DB06767 | 80 | 732 | [
"DDInter84",
"DDInter80"
] | Amphetamine | Ammonium chloride | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Ammonium chloride is an inorganic compound with the formula NH4Cl. It is highly soluble in water producing mildly acidic solutions. | Moderate | 1 | [
[
[
80,
24,
732
]
],
[
[
80,
24,
1264
],
[
1264,
23,
732
]
],
[
[
80,
40,
633
],
[
633,
24,
732
]
],
[
[
80,
24,
1264
],
[
1264,
64,... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ammonium chloride"
]
],
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a minor interaction that can limit clinical effects when taken with Ammonium chloride
Amphetamine (Compound) resembles Lisdexamfetamine (Compound) and Lisdexamfetamine may cause a moderate interacti... |
DB01149 | DB01191 | 851 | 1,039 | [
"DDInter1274",
"DDInter518"
] | Nefazodone | Dexfenfluramine | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
851,
25,
1039
]
],
[
[
851,
6,
6112
],
[
6112,
45,
1039
]
],
[
[
851,
25,
578
],
[
578,
63,
1039
]
],
[
[
851,
1,
673
],
[
673,
... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Nefazodone",
"{u} (Compound) binds {v} (Gene)",
"SLC6A4"
],
[
"SLC6A4",
"{u} (Gene) is bound by {v} (Compound)",
"De... | Nefazodone (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Dexfenfluramine (Compound)
Nefazodone may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Nefazodone (Compound) r... |
DB00176 | DB09065 | 529 | 760 | [
"DDInter770",
"DDInter424"
] | Fluvoxamine | Cobicistat | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
529,
24,
760
]
],
[
[
529,
24,
1374
],
[
1374,
23,
760
]
],
[
[
529,
24,
1195
],
[
1195,
24,
760
]
],
[
[
529,
23,
466
],
[
466,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlot... |
DB00008 | DB00682 | 491 | 126 | [
"DDInter1407",
"DDInter1951"
] | Peginterferon alfa-2a | Warfarin | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
491,
24,
126
]
],
[
[
491,
24,
168
],
[
168,
23,
126
]
],
[
[
491,
24,
671
],
[
671,
62,
126
]
],
[
[
491,
24,
14
],
[
14,
63,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezo... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Warfarin
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Flu... |
DB00741 | DB01136 | 167 | 772 | [
"DDInter885",
"DDInter305"
] | Hydrocortisone | Carvedilol | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
167,
24,
772
]
],
[
[
167,
6,
4973
],
[
4973,
45,
772
]
],
[
[
167,
21,
28734
],
[
28734,
60,
772
]
],
[
[
167,
23,
1283
],
[
1283,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compo... | Hydrocortisone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carvedilol (Compound)
Hydrocortisone (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Carvedilol (Compound)
Hydrocortisone may cause a minor interaction that can limit clinical effects w... |
DB00928 | DB06168 | 1,426 | 1,531 | [
"DDInter148",
"DDInter281"
] | Azacitidine | Canakinumab | Azacitidine is a pyrimidine nucleoside analogue with anti-neoplastic activity. It differs from cytosine by the presence of nitrogen in the C5-position, key in its hypomethylating activity.[A1406,A1413,A1415] Two main mechanisms of action have been proposed for azacitidine. One of them is the induction of cytotoxicity. ... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
1426,
24,
1531
]
],
[
[
1426,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
1426,
24,
1270
],
[
1270,
63,
1531
]
],
[
[
1426,
63,
599
],
[
599... | [
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Azacitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Azacitidine may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified pr... |
DB00691 | DB00945 | 1,058 | 1,479 | [
"DDInter1237",
"DDInter20"
] | Moexipril | Acetylsalicylic acid | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1058,
24,
1479
]
],
[
[
1058,
1,
479
],
[
479,
23,
1479
]
],
[
[
1058,
23,
1283
],
[
1283,
63,
1479
]
],
[
[
1058,
24,
714
],
[
714,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Moexipril",
"{u} (Compound) resembles {v} (Compound)",
"Donepezil"
],
[
"Donepezil",
"{u} may cause a m... | Moexipril (Compound) resembles Donepezil (Compound) and Donepezil may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid
Moexipril may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide and Magnesium oxide may cause a moderate interactio... |
DB06043 | DB15091 | 1,644 | 676 | [
"DDInter1328",
"DDInter1901"
] | Olaratumab | Upadacitinib | Olaratumab (IMC-3G3) is a fully human IgG1 monoclonal antibody with antitumor activity that selectively binds the external domain of human platelet-derived growth factor receptor (PDGFR)-α with high affinity and blocks ligand binding. It is composed of two heavy chain molecule fragments and 2 light chain fragments. Stu... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1644,
25,
676
]
],
[
[
1644,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1644,
63,
1184
],
[
1184,
25,
676
]
],
[
[
1644,
24,
270
],
[
270,
... | [
[
[
"Olaratumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Olaratumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Olaratumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Olaratumab may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and An... |
DB00794 | DB11703 | 759 | 405 | [
"DDInter1521",
"DDInter9"
] | Primidone | Acalabrutinib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
759,
25,
405
]
],
[
[
759,
63,
58
],
[
58,
24,
405
]
],
[
[
759,
62,
1101
],
[
1101,
24,
405
]
],
[
[
759,
25,
951
],
[
951,
24,... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
"Alefacept"... | Primidone may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Primidone may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexaroten... |
DB00060 | DB00218 | 912 | 1,176 | [
"DDInter947",
"DDInter1247"
] | Interferon beta-1a | Moxifloxacin | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Moderate | 1 | [
[
[
912,
24,
1176
]
],
[
[
912,
24,
37
],
[
37,
62,
1176
]
],
[
[
912,
63,
816
],
[
816,
23,
1176
]
],
[
[
912,
24,
1647
],
[
1647,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moxifloxacin"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomustine... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a minor interaction that can limit clinical effects when taken with Moxifloxacin
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Gemtuzu... |
DB00761 | DB11160 | 1,621 | 337 | [
"DDInter1497",
"DDInter1459"
] | Potassium chloride | Phenyltoloxamine | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Major | 2 | [
[
[
1621,
25,
337
]
],
[
[
1621,
25,
820
],
[
820,
24,
337
]
],
[
[
1621,
64,
999
],
[
999,
24,
337
]
],
[
[
1621,
25,
820
],
[
820,
... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
"Al... | Potassium chloride may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Potassium chloride may lead to a major life threatening interaction when taken with Thiethylperazine and Thieth... |
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