drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00180 | DB14975 | 1,351 | 988 | [
"DDInter749",
"DDInter1949"
] | Flunisolide | Voxelotor | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Moderate | 1 | [
[
[
1351,
24,
988
]
],
[
[
1351,
40,
251
],
[
251,
24,
988
]
],
[
[
1351,
1,
1486
],
[
1486,
24,
988
]
],
[
[
1351,
24,
283
],
[
283,
... | [
[
[
"Flunisolide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voxelotor"
]
],
[
[
"Flunisolide",
"{u} (Compound) resembles {v} (Compound)",
"Betamethasone"
],
[
"Betamethasone",
"{u} may cause a ... | Flunisolide (Compound) resembles Betamethasone (Compound) and Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Voxelotor
Flunisolide (Compound) resembles Methylprednisolone (Compound) and Methylprednisolone may cause a moderate interaction that could exacerbate diseases when... |
DB00574 | DB00945 | 121 | 1,479 | [
"DDInter717",
"DDInter20"
] | Fenfluramine | Acetylsalicylic acid | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
121,
24,
1479
]
],
[
[
121,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
121,
25,
1399
],
[
1399,
62,
1479
]
],
[
[
121,
23,
479
],
[
479,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic ... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Fenfluramine may lead to a major life threatening interaction when taken with Lithium ... |
DB06616 | DB09118 | 594 | 1,580 | [
"DDInter224",
"DDInter1711"
] | Bosutinib | Stiripentol | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Major | 2 | [
[
[
594,
25,
1580
]
],
[
[
594,
25,
283
],
[
283,
63,
1580
]
],
[
[
594,
24,
98
],
[
98,
24,
1580
]
],
[
[
594,
63,
79
],
[
79,
24,
... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stiripentol"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib",
"{u} ma... | Bosutinib may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may cause a mod... |
DB00398 | DB00489 | 79 | 17 | [
"DDInter1702",
"DDInter1704"
] | Sorafenib | Sotalol | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Major | 2 | [
[
[
79,
25,
17
]
],
[
[
79,
64,
347
],
[
347,
40,
17
]
],
[
[
79,
21,
28719
],
[
28719,
60,
17
]
],
[
[
79,
24,
578
],
[
578,
62,
... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sotalol"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
"{u} (Compoun... | Sorafenib may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Sotalol (Compound)
Sorafenib (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Sotalol (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when ... |
DB01394 | DB09330 | 1,554 | 985 | [
"DDInter431",
"DDInter1352"
] | Colchicine | Osimertinib | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1554,
24,
985
]
],
[
[
1554,
63,
168
],
[
168,
23,
985
]
],
[
[
1554,
25,
1478
],
[
1478,
24,
985
]
],
[
[
1554,
63,
134
],
[
134,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Colchicine may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Colchicine may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a m... |
DB01253 | DB08824 | 628 | 591 | [
"DDInter664",
"DDInter959"
] | Ergometrine | Ioflupane I-123 | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
628,
24,
591
]
],
[
[
628,
21,
28722
],
[
28722,
60,
591
]
],
[
[
628,
1,
107
],
[
107,
24,
591
]
],
[
[
628,
64,
1466
],
[
1466,
... | [
[
[
"Ergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Ergometrine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is cau... | Ergometrine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Ergometrine (Compound) resembles Pergolide (Compound) and Pergolide may cause a moderate interaction that could exacerbate diseases when taken with Ioflupane I-123
Ergometrine may lead to a major life thr... |
DB00295 | DB00450 | 475 | 78 | [
"DDInter1244",
"DDInter603"
] | Morphine | Droperidol | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Major | 2 | [
[
[
475,
25,
78
]
],
[
[
475,
25,
1300
],
[
1300,
40,
78
]
],
[
[
475,
25,
1568
],
[
1568,
1,
78
]
],
[
[
475,
21,
28921
],
[
28921,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Haloperidol"
],
[
"Haloperidol",
"{u} (Co... | Morphine may lead to a major life threatening interaction when taken with Haloperidol and Haloperidol (Compound) resembles Droperidol (Compound)
Morphine may lead to a major life threatening interaction when taken with Pimozide and Pimozide (Compound) resembles Droperidol (Compound)
Morphine (Compound) causes Dizziness... |
DB00344 | DB00451 | 1,302 | 542 | [
"DDInter1543",
"DDInter1064"
] | Protriptyline | Levothyroxine | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
1302,
24,
542
]
],
[
[
1302,
63,
1152
],
[
1152,
1,
542
]
],
[
[
1302,
6,
4973
],
[
4973,
45,
542
]
],
[
[
1302,
7,
7273
],
[
7273,
... | [
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Protriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
... | Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Levothyroxine (Compound)
Protriptyline (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Levothyroxine (Compound)
Protriptyline (Compound) upregulates GPATCH8 (Gene) ... |
DB00039 | DB00531 | 1,253 | 450 | [
"DDInter1380",
"DDInter456"
] | Palifermin | Cyclophosphamide | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the liver to form the active aldophosphamide. It has been used in the treatment of lymphoma and leukemia. Its side effect, alopecia, has been used for defleecing sheep. Cyclophosphamide may also cause steril... | Moderate | 1 | [
[
[
1253,
24,
450
]
],
[
[
1253,
24,
1001
],
[
1001,
40,
450
]
],
[
[
1253,
63,
491
],
[
491,
23,
450
]
],
[
[
1253,
24,
367
],
[
367,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclophosphamide"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mechlorethamine"
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Mechlorethamine and Mechlorethamine (Compound) resembles Cyclophosphamide (Compound)
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2a and Peginterferon alfa-2a may c... |
DB01041 | DB09559 | 770 | 432 | [
"DDInter1789",
"DDInter1272"
] | Thalidomide | Necitumumab | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Necitumumab is an intravenously administered recombinant monoclonal IgG1 antibody used in the treatment of non-small cell lung cancer (NSCLC) as an EGFR antagonist. It functions by binding to epidermal growth factor receptor (EGFR) and prevents binding of its ligands, a process that is involved in cell proliferation, m... | Major | 2 | [
[
[
770,
25,
432
]
],
[
[
770,
63,
1253
],
[
1253,
24,
432
]
],
[
[
770,
24,
222
],
[
222,
23,
384
],
[
384,
24,
432
]
],
[
[
770,
6... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Necitumumab"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palifermin"
],
[
"Palifer... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Necitumumab
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Si... |
DB00286 | DB11979 | 380 | 1,320 | [
"DDInter439",
"DDInter625"
] | Conjugated estrogens | Elagolix | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
380,
24,
1320
]
],
[
[
380,
24,
129
],
[
129,
24,
1320
]
],
[
[
380,
24,
159
],
[
159,
63,
1320
]
],
[
[
380,
1,
35
],
[
35,
24,... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutam... | Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00209 | DB08893 | 352 | 271 | [
"DDInter1886",
"DDInter1229"
] | Trospium | Mirabegron | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Moderate | 1 | [
[
[
352,
24,
271
]
],
[
[
352,
24,
1188
],
[
1188,
1,
271
]
],
[
[
352,
24,
1523
],
[
1523,
40,
271
]
],
[
[
352,
6,
12523
],
[
12523,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirabegron"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Arbutamine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Arbutamine and Arbutamine (Compound) resembles Mirabegron (Compound)
Trospium may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Mirabegron (Compound)
Trospi... |
DB00604 | DB11730 | 1,425 | 351 | [
"DDInter385",
"DDInter1588"
] | Cisapride | Ribociclib | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1425,
25,
351
]
],
[
[
1425,
23,
1247
],
[
1247,
23,
351
]
],
[
[
1425,
25,
283
],
[
283,
62,
351
]
],
[
[
1425,
24,
479
],
[
479,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfamet... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Cisapride may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may ... |
DB00518 | DB12010 | 510 | 214 | [
"DDInter35",
"DDInter785"
] | Albendazole | Fostamatinib | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
510,
24,
214
]
],
[
[
510,
24,
723
],
[
723,
24,
214
]
],
[
[
510,
23,
307
],
[
307,
24,
214
]
],
[
[
510,
24,
179
],
[
179,
63,... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Albendazole may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Albendazole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modaf... |
DB00668 | DB09100 | 874 | 320 | [
"DDInter652",
"DDInter1799"
] | Epinephrine | Thyroid, porcine | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
874,
24,
320
]
],
[
[
874,
63,
127
],
[
127,
24,
320
]
],
[
[
874,
24,
135
],
[
135,
24,
320
]
],
[
[
874,
24,
1296
],
[
1296,
6... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miglitol"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Miglitol and Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Thyroid, porcine
Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide and A... |
DB08881 | DB09074 | 868 | 1,362 | [
"DDInter1925",
"DDInter1327"
] | Vemurafenib | Olaparib | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
868,
24,
1362
]
],
[
[
868,
24,
627
],
[
627,
63,
1362
]
],
[
[
868,
64,
576
],
[
576,
24,
1362
]
],
[
[
868,
63,
2
],
[
2,
24,
... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
],
[
... | Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir and Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Vemurafenib may lead to a major life threatening interaction when taken with Methadone and Methadone may cause ... |
DB00357 | DB00990 | 1,051 | 1,547 | [
"DDInter71",
"DDInter705"
] | Aminoglutethimide | Exemestane | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Moderate | 1 | [
[
[
1051,
24,
1547
]
],
[
[
1051,
63,
380
],
[
380,
24,
1547
]
],
[
[
1051,
6,
10450
],
[
10450,
45,
1547
]
],
[
[
1051,
21,
28703
],
[
28... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exemestane"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conjugated es... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Exemestane
Aminoglutethimide (Compound) binds CYP19A1 (Gene) and CYP19A1 (Gene) is bound by Exem... |
DB00060 | DB00519 | 912 | 1,638 | [
"DDInter947",
"DDInter1843"
] | Interferon beta-1a | Trandolapril | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
912,
24,
1638
]
],
[
[
912,
24,
954
],
[
954,
40,
1638
]
],
[
[
912,
63,
1560
],
[
1560,
24,
1638
]
],
[
[
912,
24,
1662
],
[
1662,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate in... |
DB00934 | DB01246 | 413 | 820 | [
"DDInter1124",
"DDInter45"
] | Maprotiline | Alimemazine | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
413,
24,
820
]
],
[
[
413,
63,
104
],
[
104,
40,
820
]
],
[
[
413,
24,
401
],
[
401,
24,
820
]
],
[
[
413,
1,
1506
],
[
1506,
40... | [
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Maprotiline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction... |
DB00662 | DB06700 | 717 | 643 | [
"DDInter1873",
"DDInter511"
] | Trimethobenzamide | Desvenlafaxine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Desvenlafaxine (O-desmethylvenlafaxine) is the 0-demetyhlated active metabolite of [venlafaxine]. Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.[A261266,A261266] It was approved by the FDA in 2008 for the treatment of ad... | Moderate | 1 | [
[
[
717,
24,
643
]
],
[
[
717,
63,
1100
],
[
1100,
1,
643
]
],
[
[
717,
21,
28809
],
[
28809,
60,
643
]
],
[
[
717,
63,
530
],
[
530,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxi... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine (Compound) resembles Desvenlafaxine (Compound)
Trimethobenzamide (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Desvenlafaxine (Compound)
Trimethobenzamide ma... |
DB00539 | DB13179 | 11 | 68 | [
"DDInter1837",
"DDInter1882"
] | Toremifene | Troleandomycin | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
11,
25,
68
]
],
[
[
11,
63,
1101
],
[
1101,
23,
68
]
],
[
[
11,
25,
1374
],
[
1374,
23,
68
]
],
[
[
11,
25,
1662
],
[
1662,
24,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexaro... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Toremifene may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may ca... |
DB00384 | DB01088 | 1,275 | 714 | [
"DDInter1859",
"DDInter908"
] | Triamterene | Iloprost | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1275,
24,
714
]
],
[
[
1275,
63,
1648
],
[
1648,
24,
714
]
],
[
[
1275,
24,
1450
],
[
1450,
63,
714
]
],
[
[
1275,
24,
848
],
[
848,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Iloprost
Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and E... |
DB00224 | DB11901 | 215 | 913 | [
"DDInter917",
"DDInter107"
] | Indinavir | Apalutamide | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
215,
24,
913
]
],
[
[
215,
24,
608
],
[
608,
23,
913
]
],
[
[
215,
62,
600
],
[
600,
24,
913
]
],
[
[
215,
23,
303
],
[
303,
24,... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
... | Indinavir may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Indinavir may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluconazole ... |
DB00041 | DB10316 | 1,648 | 334 | [
"DDInter38",
"DDInter1248"
] | Aldesleukin | Mumps virus strain B level jeryl lynn live antigen | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1648,
25,
334
]
],
[
[
1648,
24,
1042
],
[
1042,
24,
334
]
],
[
[
1648,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1648,
24,
328
],
[
328,
... | [
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide and Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Mumps virus strain B level jeryl lynn live antigen
Aldesleukin may lead to a major life threatening interaction wh... |
DB00980 | DB06691 | 969 | 849 | [
"DDInter1564",
"DDInter1155"
] | Ramelteon | Mepyramine | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
969,
24,
849
]
],
[
[
969,
63,
1594
],
[
1594,
24,
849
]
],
[
[
969,
24,
272
],
[
272,
24,
849
]
],
[
[
969,
24,
407
],
[
407,
6... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Ch... |
DB01042 | DB06674 | 1,307 | 908 | [
"DDInter1144",
"DDInter837"
] | Melphalan | Golimumab | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
1307,
25,
908
]
],
[
[
1307,
23,
1193
],
[
1193,
62,
908
]
],
[
[
1307,
63,
1461
],
[
1461,
23,
908
]
],
[
[
1307,
24,
200
],
[
200,
... | [
[
[
"Melphalan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Melphalan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Zinc glucon... | Melphalan may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Golimumab
Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitami... |
DB00400 | DB00820 | 353 | 402 | [
"DDInter843",
"DDInter1736"
] | Griseofulvin | Tadalafil | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Moderate | 1 | [
[
[
353,
24,
402
]
],
[
[
353,
6,
8374
],
[
8374,
45,
402
]
],
[
[
353,
21,
29196
],
[
29196,
60,
402
]
],
[
[
353,
24,
159
],
[
159,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tadalafil"
]
],
[
[
"Griseofulvin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Griseofulvin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tadalafil (Compound)
Griseofulvin (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Tadalafil (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Larotrect... |
DB00196 | DB00307 | 600 | 1,101 | [
"DDInter743",
"DDInter202"
] | Fluconazole | Bexarotene | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Minor | 0 | [
[
[
600,
23,
1101
]
],
[
[
600,
6,
8374
],
[
8374,
45,
1101
]
],
[
[
600,
21,
28762
],
[
28762,
60,
1101
]
],
[
[
600,
24,
608
],
[
608,
... | [
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bexarotene (Compound)
Fluconazole (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Bexarotene (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lido... |
DB00382 | DB06699 | 62 | 774 | [
"DDInter1734",
"DDInter493"
] | Tacrine | Degarelix | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
62,
24,
774
]
],
[
[
62,
63,
521
],
[
521,
1,
774
]
],
[
[
62,
24,
112
],
[
112,
23,
774
]
],
[
[
62,
24,
888
],
[
888,
24,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
"Gos... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit c... |
DB00691 | DB01246 | 1,058 | 820 | [
"DDInter1237",
"DDInter45"
] | Moexipril | Alimemazine | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1058,
24,
820
]
],
[
[
1058,
24,
104
],
[
104,
40,
820
]
],
[
[
1058,
24,
401
],
[
401,
24,
820
]
],
[
[
1058,
23,
286
],
[
286,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction tha... |
DB00872 | DB04868 | 1,080 | 478 | [
"DDInter438",
"DDInter1293"
] | Conivaptan | Nilotinib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1080,
25,
478
]
],
[
[
1080,
25,
1468
],
[
1468,
63,
478
]
],
[
[
1080,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1080,
21,
28762
],
[
28762... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} may ... | Conivaptan may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Conivaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Conivaptan (Compound) causes Headache... |
DB11581 | DB15093 | 1,456 | 1,654 | [
"DDInter1926",
"DDInter1698"
] | Venetoclax | Somapacitan | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process,. Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small lym... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1456,
24,
1654
]
],
[
[
1456,
62,
1135
],
[
1135,
24,
1654
]
],
[
[
1456,
25,
351
],
[
351,
24,
1654
]
],
[
[
1456,
63,
1250
],
[
1250... | [
[
[
"Venetoclax",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Venetoclax",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Venetoclax may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Venetoclax may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a m... |
DB01004 | DB05239 | 563 | 866 | [
"DDInter806",
"DDInter425"
] | Ganciclovir | Cobimetinib | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
563,
24,
866
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],
[
[
563,
63,
482
],
[
482,
24,
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]
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[
[
563,
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248
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[
248,
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],
[
[
563,
24,
869
],
[
869,
24,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
[... | Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Ganciclovir (Compound) resembles Valganciclovir (Compound) and Val
Ganciclovir may cause a moderate interactio... |
DB01065 | DB09074 | 43 | 1,362 | [
"DDInter1142",
"DDInter1327"
] | Melatonin | Olaparib | Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland. The pineal gland is small endocrine gland, about the size of a rice g... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
43,
24,
1362
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[
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62,
1684
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[
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[
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43,
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[
1619,
63,
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]
],
[
[
43,
63,
702
],
[
702,
... | [
[
[
"Melatonin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Melatonin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Caffeine"
],
[
"Caf... | Melatonin may cause a minor interaction that can limit clinical effects when taken with Caffeine and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Melatonin may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cau... |
DB00367 | DB08889 | 566 | 350 | [
"DDInter1061",
"DDInter299"
] | Levonorgestrel | Carfilzomib | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Major | 2 | [
[
[
566,
25,
350
]
],
[
[
566,
18,
5795
],
[
5795,
45,
350
]
],
[
[
566,
21,
28762
],
[
28762,
60,
350
]
],
[
[
566,
24,
1362
],
[
1362,
... | [
[
[
"Levonorgestrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) downregulates {v} (Gene)",
"PSMB8"
],
[
"PSMB8",
"{u} (Gene) is bound by {v} (Compound)",... | Levonorgestrel (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is bound by Carfilzomib (Compound)
Levonorgestrel (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with O... |
DB00557 | DB04837 | 252 | 649 | [
"DDInter895",
"DDInter407"
] | Hydroxyzine | Clofedanol | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
252,
24,
649
]
],
[
[
252,
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],
[
1376,
24,
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]
],
[
[
252,
24,
832
],
[
832,
40,
649
]
],
[
[
252,
74,
701
],
[
701,
2... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Tripelenn... |
DB00641 | DB00701 | 467 | 1,091 | [
"DDInter1675",
"DDInter90"
] | Simvastatin | Amprenavir | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Amprenavir is a protease inhibitor used to treat HIV infection. | Major | 2 | [
[
[
467,
25,
1091
]
],
[
[
467,
25,
34
],
[
34,
1,
1091
]
],
[
[
467,
6,
4973
],
[
4973,
45,
1091
]
],
[
[
467,
21,
28996
],
[
28996,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
]
],
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosamprenavir"
],
[
"Fosamprenavir",
... | Simvastatin may lead to a major life threatening interaction when taken with Fosamprenavir and Fosamprenavir (Compound) resembles Amprenavir (Compound)
Simvastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Amprenavir (Compound)
Simvastatin (Compound) causes Musculoskeletal discomfort (Side Effect) and ... |
DB00439 | DB00570 | 289 | 147 | [
"DDInter341",
"DDInter1936"
] | Cerivastatin | Vinblastine | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
289,
24,
147
]
],
[
[
289,
63,
134
],
[
134,
24,
147
]
],
[
[
289,
24,
896
],
[
896,
62,
147
]
],
[
[
289,
24,
63
],
[
63,
23,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and ... |
DB00731 | DB08880 | 1,144 | 1,510 | [
"DDInter1269",
"DDInter1771"
] | Nateglinide | Teriflunomide | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Moderate | 1 | [
[
[
1144,
24,
1510
]
],
[
[
1144,
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],
[
129,
63,
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],
[
[
1144,
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303
],
[
303,
24,
1510
]
],
[
[
1144,
24,
170
],
[
170,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teriflunomide"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Medroxyproge... |
DB00502 | DB01246 | 1,300 | 820 | [
"DDInter853",
"DDInter45"
] | Haloperidol | Alimemazine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | A phenothiazine derivative that is used as an antipruritic. | Major | 2 | [
[
[
1300,
25,
820
]
],
[
[
1300,
24,
104
],
[
104,
40,
820
]
],
[
[
1300,
25,
401
],
[
401,
24,
820
]
],
[
[
1300,
24,
649
],
[
649,
... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
"Methd... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Haloperidol may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exa... |
DB00794 | DB06168 | 759 | 1,531 | [
"DDInter1521",
"DDInter281"
] | Primidone | Canakinumab | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
759,
24,
1531
]
],
[
[
759,
25,
1362
],
[
1362,
63,
1531
]
],
[
[
759,
25,
1213
],
[
1213,
24,
1531
]
],
[
[
759,
63,
1031
],
[
1031,
... | [
[
[
"Primidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
],
[
"Olaparib",
... | Primidone may lead to a major life threatening interaction when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab
Primidone may lead to a major life threatening interaction when taken with Dasatinib and Dasatinib may cause a moderate interaction... |
DB01197 | DB09122 | 1,603 | 1,613 | [
"DDInter292",
"DDInter1409"
] | Captopril | Peginterferon beta-1a | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1603,
24,
1613
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],
[
[
1603,
63,
1274
],
[
1274,
24,
1613
]
],
[
[
1603,
24,
1383
],
[
1383,
63,
1613
]
],
[
[
1603,
40,
610
],
[
610... | [
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Captopril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Captopril may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Captopril may cause a moderate interaction that could exacerbate diseases when taken with Sodium s... |
DB00281 | DB09330 | 608 | 985 | [
"DDInter1066",
"DDInter1352"
] | Lidocaine | Osimertinib | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Minor | 0 | [
[
[
608,
23,
985
]
],
[
[
608,
24,
1478
],
[
1478,
24,
985
]
],
[
[
608,
23,
1598
],
[
1598,
63,
985
]
],
[
[
608,
23,
1040
],
[
1040,
... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Osimertinib"
]
],
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Lidocaine may cause a minor interaction that can limit clinical effects when taken with Tazemetostat and Tazemetos... |
DB00283 | DB00674 | 701 | 1,516 | [
"DDInter395",
"DDInter802"
] | Clemastine | Galantamine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Moderate | 1 | [
[
[
701,
24,
1516
]
],
[
[
701,
24,
475
],
[
475,
40,
1516
]
],
[
[
701,
6,
8374
],
[
8374,
45,
1516
]
],
[
[
701,
21,
28766
],
[
28766,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Galantamine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Morphine"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine (Compound) resembles Galantamine (Compound)
Clemastine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Galantamine (Compound)
Clemastine (Compound) causes Hypotension (Side Effect) and Hypotensi... |
DB06603 | DB06822 | 39 | 802 | [
"DDInter1387",
"DDInter1812"
] | Panobinostat | Tinzaparin | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
39,
25,
802
]
],
[
[
39,
63,
383
],
[
383,
24,
802
]
],
[
[
39,
64,
758
],
[
758,
24,
802
]
],
[
[
39,
25,
1427
],
[
1427,
63,
... | [
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Panobinostat may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Tinzaparin
Panobinostat may lead to a major life threatening interaction when taken with Fluoxetine a... |
DB00254 | DB00353 | 964 | 588 | [
"DDInter598",
"DDInter1187"
] | Doxycycline | Methylergometrine | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Moderate | 1 | [
[
[
964,
24,
588
]
],
[
[
964,
24,
826
],
[
826,
40,
588
]
],
[
[
964,
63,
1131
],
[
1131,
40,
588
]
],
[
[
964,
24,
628
],
[
628,
1... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylergometrine"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergotamine"
],... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Methylergometrine (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) resembles Methylerg... |
DB01181 | DB01619 | 1,532 | 830 | [
"DDInter906",
"DDInter1441"
] | Ifosfamide | Phenindamine | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1532,
24,
830
]
],
[
[
1532,
63,
1251
],
[
1251,
1,
830
]
],
[
[
1532,
63,
537
],
[
537,
40,
830
]
],
[
[
1532,
63,
1335
],
[
1335,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mirtazapine"
],
[... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Mirtazapine and Mirtazapine (Compound) resembles Phenindamine (Compound)
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compou... |
DB08889 | DB14761 | 350 | 242 | [
"DDInter299",
"DDInter1578"
] | Carfilzomib | Remdesivir | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19), which is a respiratory disease that is capable of progressing to viral pneumonia and acute respiratory distress syndrome (ARDS); COVID-19 can be fatal. Like other RNA viruses, SARS-CoV-2 depends o... | Moderate | 1 | [
[
[
350,
24,
242
]
],
[
[
350,
63,
467
],
[
467,
24,
242
]
],
[
[
350,
64,
1377
],
[
1377,
24,
242
]
],
[
[
350,
24,
384
],
[
384,
2... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir
Carfilzomib may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may ... |
DB00277 | DB12332 | 1,031 | 1,619 | [
"DDInter1791",
"DDInter1626"
] | Theophylline | Rucaparib | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1031,
24,
1619
]
],
[
[
1031,
24,
259
],
[
259,
24,
1619
]
],
[
[
1031,
23,
84
],
[
84,
24,
1619
]
],
[
[
1031,
63,
58
],
[
58,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
],
[... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Theophylline may cause a minor interaction that can limit clinical effects when taken with Nisoldipine and Niso... |
DB01169 | DB08871 | 57 | 36 | [
"DDInter120",
"DDInter666"
] | Arsenic trioxide | Eribulin | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
57,
25,
36
]
],
[
[
57,
62,
1247
],
[
1247,
23,
36
]
],
[
[
57,
25,
519
],
[
519,
24,
36
]
],
[
[
57,
64,
1424
],
[
1424,
24,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Eribulin
Arsenic trioxide may lead to a major life threatening interaction when taken with Paliperidone and P... |
DB01244 | DB08816 | 762 | 578 | [
"DDInter192",
"DDInter1802"
] | Bepridil | Ticagrelor | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
762,
24,
578
]
],
[
[
762,
6,
4973
],
[
4973,
45,
578
]
],
[
[
762,
21,
28645
],
[
28645,
60,
578
]
],
[
[
762,
23,
1135
],
[
1135,
... | [
[
[
"Bepridil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Bepridil",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Bepridil (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Bepridil (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Ticagrelor (Compound)
Bepridil may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a m... |
DB01193 | DB08946 | 819 | 512 | [
"DDInter12",
"DDInter962"
] | Acebutolol | Iopanoic acid | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Moderate | 1 | [
[
[
819,
24,
512
]
],
[
[
819,
24,
1106
],
[
1106,
24,
512
]
],
[
[
819,
40,
88
],
[
88,
24,
512
]
],
[
[
819,
24,
777
],
[
777,
63,... | [
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopanoic acid"
]
],
[
[
"Acebutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadofosveset trisodium"
... | Acebutolol may cause a moderate interaction that could exacerbate diseases when taken with Gadofosveset trisodium and Gadofosveset trisodium may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid
Acebutolol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a mode... |
DB00092 | DB01035 | 58 | 1,401 | [
"DDInter40",
"DDInter1524"
] | Alefacept | Procainamide | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | A derivative of procaine with less CNS action. | Moderate | 1 | [
[
[
58,
24,
1401
]
],
[
[
58,
24,
1683
],
[
1683,
63,
1401
]
],
[
[
58,
63,
581
],
[
581,
24,
1401
]
],
[
[
58,
25,
976
],
[
976,
63... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procainamide"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Procainamide
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Infliximab and Infl... |
DB00544 | DB00851 | 970 | 611 | [
"DDInter757",
"DDInter463"
] | Fluorouracil | Dacarbazine | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Moderate | 1 | [
[
[
970,
24,
611
]
],
[
[
970,
5,
11656
],
[
11656,
44,
611
]
],
[
[
970,
6,
7950
],
[
7950,
45,
611
]
],
[
[
970,
23,
739
],
[
739,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacarbazine"
]
],
[
[
"Fluorouracil",
"{u} (Compound) treats {v} (Disease)",
"skin cancer"
],
[
"skin cancer",
"{u} (Disease) is tre... | Fluorouracil (Compound) treats skin cancer (Disease) and skin cancer (Disease) is treated by Dacarbazine (Compound)
Fluorouracil (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Dacarbazine (Compound)
Fluorouracil may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and... |
DB01319 | DB06655 | 34 | 5 | [
"DDInter777",
"DDInter1077"
] | Fosamprenavir | Liraglutide | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
34,
24,
5
]
],
[
[
34,
63,
353
],
[
353,
23,
5
]
],
[
[
34,
63,
1142
],
[
1142,
24,
5
]
],
[
[
34,
24,
1491
],
[
1491,
24,
... | [
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
],... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Griseofulvin may cause a minor interaction that can limit clinical effects when taken with Liraglutide
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Orlistat and... |
DB00575 | DB00959 | 1,020 | 1,486 | [
"DDInter412",
"DDInter1191"
] | Clonidine | Methylprednisolone | Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors. This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
1020,
24,
1486
]
],
[
[
1020,
24,
175
],
[
175,
40,
1486
]
],
[
[
1020,
24,
167
],
[
167,
1,
1486
]
],
[
[
1020,
63,
251
],
[
251,
... | [
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Clonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],... | Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Me... |
DB00703 | DB09472 | 997 | 1,383 | [
"DDInter1167",
"DDInter1693"
] | Methazolamide | Sodium sulfate | A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
997,
24,
1383
]
],
[
[
997,
40,
471
],
[
471,
24,
1383
]
],
[
[
997,
24,
657
],
[
657,
63,
1383
]
],
[
[
997,
25,
1479
],
[
1479,
... | [
[
[
"Methazolamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Methazolamide",
"{u} (Compound) resembles {v} (Compound)",
"Acetazolamide"
],
[
"Acetazolamide",
"{u} may... | Methazolamide (Compound) resembles Acetazolamide (Compound) and Acetazolamide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Methazolamide may cause a moderate interaction that could exacerbate diseases when taken with Castor oil and Castor oil may cause a moderate intera... |
DB00014 | DB11978 | 521 | 124 | [
"DDInter839",
"DDInter822"
] | Goserelin | Glasdegib | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Moderate | 1 | [
[
[
521,
24,
124
]
],
[
[
521,
23,
1247
],
[
1247,
23,
124
]
],
[
[
521,
24,
1079
],
[
1079,
24,
124
]
],
[
[
521,
24,
1032
],
[
1032,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
]
],
[
[
"Goserelin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
... | Goserelin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Telavancin and T... |
DB00461 | DB01362 | 598 | 497 | [
"DDInter1254",
"DDInter960"
] | Nabumetone | Iohexol | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
598,
25,
497
]
],
[
[
598,
25,
258
],
[
258,
40,
497
]
],
[
[
598,
21,
28681
],
[
28681,
60,
497
]
],
[
[
598,
24,
891
],
[
891,
... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (Compo... | Nabumetone may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Nabumetone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Nabumetone may cause a moderate interaction that coul... |
DB00476 | DB00486 | 109 | 1,614 | [
"DDInter608",
"DDInter1253"
] | Duloxetine | Nabilone | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
109,
24,
1614
]
],
[
[
109,
63,
530
],
[
530,
1,
1614
]
],
[
[
109,
21,
28789
],
[
28789,
60,
1614
]
],
[
[
109,
63,
999
],
[
999,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
[
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Duloxetine (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nabilone (Compound)
Duloxetine may cause a m... |
DB00557 | DB01177 | 252 | 77 | [
"DDInter895",
"DDInter904"
] | Hydroxyzine | Idarubicin | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
252,
24,
77
]
],
[
[
252,
6,
12523
],
[
12523,
45,
77
]
],
[
[
252,
21,
28787
],
[
28787,
60,
77
]
],
[
[
252,
23,
112
],
[
112,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)... | Hydroxyzine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Hydroxyzine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Idarubicin (Compound)
Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Metronidazole an... |
DB00227 | DB09036 | 1,463 | 812 | [
"DDInter1098",
"DDInter1668"
] | Lovastatin | Siltuximab | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Moderate | 1 | [
[
[
1463,
24,
812
]
],
[
[
1463,
24,
147
],
[
147,
24,
812
]
],
[
[
1463,
35,
467
],
[
467,
24,
812
]
],
[
[
1463,
63,
1184
],
[
1184,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Siltuximab"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Siltuximab
Lovastatin (Compound) resembles Simvastatin (Compound) and Lovastatin may cause a moderate interaction that co... |
DB00290 | DB08826 | 329 | 1,292 | [
"DDInter219",
"DDInter489"
] | Bleomycin | Deferiprone | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
329,
25,
1292
]
],
[
[
329,
21,
28996
],
[
28996,
60,
1292
]
],
[
[
329,
24,
482
],
[
482,
25,
1292
]
],
[
[
329,
63,
552
],
[
552,
... | [
[
[
"Bleomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Bleomycin",
"{u} (Compound) causes {v} (Side Effect)",
"Musculoskeletal discomfort"
],
[
"Musculoskeletal discomfort",
"{u} (Si... | Bleomycin (Compound) causes Musculoskeletal discomfort (Side Effect) and Musculoskeletal discomfort (Side Effect) is caused by Deferiprone (Compound)
Bleomycin may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may lead to a major life threatening interaction when ... |
DB00530 | DB14730 | 1,195 | 1,412 | [
"DDInter667",
"DDInter264"
] | Erlotinib | Calaspargase pegol | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1195,
24,
1412
]
],
[
[
1195,
24,
159
],
[
159,
24,
1412
]
],
[
[
1195,
1,
883
],
[
883,
24,
1412
]
],
[
[
1195,
63,
322
],
[
322,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Erlotinib (Compound) resembles Gefitinib (Compound) and Gefitinib may cause a moderate interaction ... |
DB01225 | DB12364 | 500 | 1,421 | [
"DDInter645",
"DDInter200"
] | Enoxaparin | Betrixaban | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
500,
25,
1421
]
],
[
[
500,
23,
297
],
[
297,
23,
1421
]
],
[
[
500,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
500,
24,
992
],
[
992,
... | [
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Enoxaparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u... | Enoxaparin may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Enoxaparin may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a min... |
DB00656 | DB01041 | 827 | 770 | [
"DDInter1851",
"DDInter1789"
] | Trazodone | Thalidomide | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
827,
24,
770
]
],
[
[
827,
6,
7524
],
[
7524,
45,
770
]
],
[
[
827,
21,
29177
],
[
29177,
60,
770
]
],
[
[
827,
24,
609
],
[
609,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Trazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
... | Trazodone (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Trazodone (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Thalidomide (Compound)
Trazodone may cause a moderate interaction that could exacerbate diseases when... |
DB00647 | DB01064 | 675 | 1,148 | [
"DDInter528",
"DDInter987"
] | Dextropropoxyphene | Isoprenaline | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
675,
24,
1148
]
],
[
[
675,
24,
480
],
[
480,
24,
1148
]
],
[
[
675,
7,
5178
],
[
5178,
46,
1148
]
],
[
[
675,
18,
2183
],
[
2183,
... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formotero... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Dextropropoxyphene (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Isoprenaline (... |
DB00424 | DB04861 | 19 | 1,592 | [
"DDInter896",
"DDInter1271"
] | Hyoscyamine | Nebivolol | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
19,
24,
1592
]
],
[
[
19,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
19,
24,
1528
],
[
1528,
24,
1592
]
],
[
[
19,
24,
849
],
[
849,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Hyoscyamine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cause... | Hyoscyamine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine and Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Ne... |
DB00995 | DB04865 | 1,112 | 4 | [
"DDInter139",
"DDInter1335"
] | Auranofin | Omacetaxine mepesuccinate | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
1112,
24,
4
]
],
[
[
1112,
18,
7176
],
[
7176,
46,
4
]
],
[
[
1112,
7,
11955
],
[
11955,
46,
4
]
],
[
[
1112,
18,
10488
],
[
10488,
... | [
[
[
"Auranofin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Auranofin",
"{u} (Compound) downregulates {v} (Gene)",
"NUP88"
],
[
"NUP88",
"{u} (Gene) is upregu... | Auranofin (Compound) downregulates NUP88 (Gene) and NUP88 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Auranofin (Compound) upregulates SYNGR3 (Gene) and SYNGR3 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Auranofin (Compound) downregulates B4GAT1 (Gene) and B4GAT1 (Gene) is downregula... |
DB00526 | DB01030 | 1,555 | 869 | [
"DDInter1355",
"DDInter1835"
] | Oxaliplatin | Topotecan | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Major | 2 | [
[
[
1555,
25,
869
]
],
[
[
1555,
24,
613
],
[
613,
24,
869
]
],
[
[
1555,
6,
17404
],
[
17404,
45,
869
]
],
[
[
1555,
24,
872
],
[
872,
... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Topotecan"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
],
[
"Irinoteca... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Oxaliplatin (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Topotecan (Compound)
Oxaliplatin may caus... |
DB01166 | DB14723 | 477 | 159 | [
"DDInter379",
"DDInter1026"
] | Cilostazol | Larotrectinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
477,
24,
159
]
],
[
[
477,
63,
222
],
[
222,
23,
159
]
],
[
[
477,
24,
318
],
[
318,
23,
159
]
],
[
[
477,
24,
1375
],
[
1375,
2... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and E... |
DB00176 | DB12010 | 529 | 214 | [
"DDInter770",
"DDInter785"
] | Fluvoxamine | Fostamatinib | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
529,
24,
214
]
],
[
[
529,
24,
976
],
[
976,
24,
214
]
],
[
[
529,
25,
1031
],
[
1031,
24,
214
]
],
[
[
529,
24,
1421
],
[
1421,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
],
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Fluvoxamine may lead to a major life threatening interaction when taken with Theophylline and Theophylline ... |
DB00281 | DB00379 | 608 | 143 | [
"DDInter1066",
"DDInter1206"
] | Lidocaine | Mexiletine | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Moderate | 1 | [
[
[
608,
24,
143
]
],
[
[
608,
35,
571
],
[
571,
40,
143
]
],
[
[
608,
6,
7603
],
[
7603,
45,
143
]
],
[
[
608,
21,
28653
],
[
28653,
... | [
[
[
"Lidocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mexiletine"
]
],
[
[
"Lidocaine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Lidocaine (Compound) resembles Tocainide (Compound) and Lidocaine may cause a moderate interaction that could exacerbate diseases when taken with Tocainide and Tocainide (Compound) resembles Mexiletine (Compound)
Lidocaine (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Mexiletine (Compound)
Lidocaine (Com... |
DB10276 | DB11921 | 1,624 | 1,019 | [
"DDInter1623",
"DDInter492"
] | Rotavirus vaccine | Deflazacort | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
1624,
25,
1019
]
],
[
[
1624,
25,
270
],
[
270,
63,
1019
]
],
[
[
1624,
64,
629
],
[
629,
24,
1019
]
],
[
[
1624,
25,
1316
],
[
1316,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
],
[
"Ocrelizum... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Rotavirus vaccine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause ... |
DB00526 | DB00656 | 1,555 | 827 | [
"DDInter1355",
"DDInter1851"
] | Oxaliplatin | Trazodone | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Moderate | 1 | [
[
[
1555,
24,
827
]
],
[
[
1555,
24,
623
],
[
623,
40,
827
]
],
[
[
1555,
24,
1630
],
[
1630,
1,
827
]
],
[
[
1555,
64,
695
],
[
695,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trazodone"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Trazodone (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Trazodone (Compou... |
DB00261 | DB01244 | 702 | 762 | [
"DDInter93",
"DDInter192"
] | Anagrelide | Bepridil | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
702,
25,
762
]
],
[
[
702,
25,
675
],
[
675,
40,
762
]
],
[
[
702,
21,
28698
],
[
28698,
60,
762
]
],
[
[
702,
23,
112
],
[
112,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextropropoxyphene"
],
[
"Dextropropoxyphene"... | Anagrelide may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Bepridil (Compound)
Anagrelide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Bepridil (Compound)
Anagrelide may cause a minor interaction that can... |
DB00388 | DB01396 | 1,636 | 1,482 | [
"DDInter1453",
"DDInter553"
] | Phenylephrine | Digitoxin | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | A cardiac glycoside sometimes used in place of digoxin. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665) | Moderate | 1 | [
[
[
1636,
24,
1482
]
],
[
[
1636,
24,
1252
],
[
1252,
1,
1482
]
],
[
[
1636,
24,
885
],
[
885,
23,
1482
]
],
[
[
1636,
24,
542
],
[
542,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
[
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin (Compound) resembles Digitoxin (Compound)
Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can l... |
DB00620 | DB14443 | 175 | 987 | [
"DDInter1855",
"DDInter1931"
] | Triamcinolone | Vibrio cholerae CVD 103-HgR strain live antigen | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
175,
24,
987
]
],
[
[
175,
40,
1220
],
[
1220,
24,
987
]
],
[
[
175,
24,
351
],
[
351,
24,
987
]
],
[
[
175,
63,
305
],
[
305,
2... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Triamcinolone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
... | Triamcinolone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboc... |
DB00950 | DB09420 | 1,413 | 1,074 | [
"DDInter732",
"DDInter953"
] | Fexofenadine | Iodide I-123 | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
1413,
24,
1074
]
],
[
[
1413,
1,
1242
],
[
1242,
24,
1074
]
],
[
[
1413,
23,
771
],
[
771,
62,
516
],
[
516,
24,
1074
]
],
[
[
1413,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Fexofenadine",
"{u} (Compound) resembles {v} (Compound)",
"Cetirizine"
],
[
"Cetirizine",
"{u} may cause a m... | Fexofenadine (Compound) resembles Cetirizine (Compound) and Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Fexofenadine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction tha... |
DB09038 | DB11901 | 1,450 | 913 | [
"DDInter636",
"DDInter107"
] | Empagliflozin | Apalutamide | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1450,
24,
913
]
],
[
[
1450,
63,
312
],
[
312,
23,
913
]
],
[
[
1450,
24,
1060
],
[
1060,
62,
913
]
],
[
[
1450,
63,
303
],
[
303,
... | [
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Empagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eplerenone"
],
... | Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedot... |
DB00176 | DB01191 | 529 | 1,039 | [
"DDInter770",
"DDInter518"
] | Fluvoxamine | Dexfenfluramine | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Major | 2 | [
[
[
529,
25,
1039
]
],
[
[
529,
6,
6112
],
[
6112,
45,
1039
]
],
[
[
529,
18,
2551
],
[
2551,
57,
1039
]
],
[
[
529,
24,
1045
],
[
1045,
... | [
[
[
"Fluvoxamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A4"
],
[
"SLC6A4",
"{u} (Gene) is bound by {v} (Compound)",
"... | Fluvoxamine (Compound) binds SLC6A4 (Gene) and SLC6A4 (Gene) is bound by Dexfenfluramine (Compound)
Fluvoxamine (Compound) downregulates PFN1 (Gene) and PFN1 (Gene) is downregulated by Dexfenfluramine (Compound)
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib and ... |
DB09052 | DB15091 | 250 | 676 | [
"DDInter220",
"DDInter1901"
] | Blinatumomab | Upadacitinib | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
250,
25,
676
]
],
[
[
250,
63,
1430
],
[
1430,
24,
676
]
],
[
[
250,
24,
748
],
[
748,
24,
676
]
],
[
[
250,
63,
1184
],
[
1184,
... | [
[
[
"Blinatumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Si... | Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vac... |
DB00169 | DB00615 | 386 | 690 | [
"DDInter367",
"DDInter1589"
] | Cholecalciferol | Rifabutin | Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-... | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
386,
24,
690
]
],
[
[
386,
24,
463
],
[
463,
1,
690
]
],
[
[
386,
6,
8374
],
[
8374,
45,
690
]
],
[
[
386,
25,
1196
],
[
1196,
6... | [
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],... | Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Cholecalciferol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Cholecalciferol may lead to a major life threatening inter... |
DB01169 | DB12245 | 57 | 823 | [
"DDInter120",
"DDInter1863"
] | Arsenic trioxide | Triclabendazole | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Major | 2 | [
[
[
57,
25,
823
]
],
[
[
57,
62,
1247
],
[
1247,
23,
823
]
],
[
[
57,
25,
1612
],
[
1612,
24,
823
]
],
[
[
57,
64,
1010
],
[
1010,
2... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
]
],
[
[
"Arsenic trioxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Arsenic trioxide may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Arsenic trioxide may lead to a major life threatening interaction when taken with Fostemsavir... |
DB08896 | DB09122 | 292 | 1,613 | [
"DDInter1576",
"DDInter1409"
] | Regorafenib | Peginterferon beta-1a | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
292,
24,
1613
]
],
[
[
292,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
292,
24,
1155
],
[
1155,
63,
1613
]
],
[
[
292,
76,
1274
],
[
1274,
... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
... | Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Regorafenib may cause a moderate interaction that could exacerbate diseases when taken with Tucati... |
DB00987 | DB08870 | 1,224 | 850 | [
"DDInter460",
"DDInter228"
] | Cytarabine | Brentuximab vedotin | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1224,
24,
850
]
],
[
[
1224,
24,
496
],
[
496,
63,
850
]
],
[
[
1224,
63,
611
],
[
611,
24,
850
]
],
[
[
1224,
24,
259
],
[
259,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccin... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Cytarabine may cause a moderate interaction that could exacerbate diseases when taken... |
DB00687 | DB06717 | 870 | 875 | [
"DDInter747",
"DDInter778"
] | Fludrocortisone | Fosaprepitant | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
870,
24,
875
]
],
[
[
870,
63,
723
],
[
723,
1,
875
]
],
[
[
870,
21,
29180
],
[
29180,
60,
875
]
],
[
[
870,
63,
1101
],
[
1101,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Fludrocortisone (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Fosaprepitant (Compound)
Fludro... |
DB00601 | DB08865 | 453 | 1,593 | [
"DDInter1073",
"DDInter448"
] | Linezolid | Crizotinib | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
453,
24,
1593
]
],
[
[
453,
7,
2900
],
[
2900,
46,
1593
]
],
[
[
453,
18,
2023
],
[
2023,
46,
1593
]
],
[
[
453,
21,
29093
],
[
29093,... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Linezolid",
"{u} (Compound) upregulates {v} (Gene)",
"NFKBIA"
],
[
"NFKBIA",
"{u} (Gene) is upregulated by {v} (C... | Linezolid (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is upregulated by Crizotinib (Compound)
Linezolid (Compound) downregulates RAP1GAP (Gene) and RAP1GAP (Gene) is upregulated by Crizotinib (Compound)
Linezolid (Compound) causes Fatigue (Side Effect) and Fatigue (Side Effect) is caused by Crizotinib (Compo... |
DB05812 | DB13179 | 1,374 | 68 | [
"DDInter8",
"DDInter1882"
] | Abiraterone | Troleandomycin | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | A macrolide antibiotic that is similar to erythromycin. | Minor | 0 | [
[
[
1374,
23,
68
]
],
[
[
1374,
23,
466
],
[
466,
23,
68
]
],
[
[
1374,
63,
973
],
[
973,
24,
68
]
],
[
[
1374,
24,
710
],
[
710,
24... | [
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Troleandomycin"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and ... |
DB00794 | DB06626 | 759 | 263 | [
"DDInter1521",
"DDInter147"
] | Primidone | Axitinib | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
759,
25,
263
]
],
[
[
759,
62,
752
],
[
752,
23,
263
]
],
[
[
759,
24,
392
],
[
392,
24,
263
]
],
[
[
759,
25,
1593
],
[
1593,
6... | [
[
[
"Primidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Primidone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
],
[
"Cimetidine",
... | Primidone may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Axitinib
Primidone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may c... |
DB00436 | DB11348 | 323 | 1,065 | [
"DDInter179",
"DDInter279"
] | Bendroflumethiazide | Calcium Phosphate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
323,
24,
1065
]
],
[
[
323,
40,
1014
],
[
1014,
24,
1065
]
],
[
[
323,
23,
1620
],
[
1620,
24,
1065
]
],
[
[
323,
62,
964
],
[
964,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) resembles {v} (Compound)",
"Benzthiazide"
],
[
"Benzthiazide",
... | Bendroflumethiazide (Compound) resembles Benzthiazide (Compound) and Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Bendroflumethiazide may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline may cause a ... |
DB06777 | DB13873 | 780 | 1,534 | [
"DDInter348",
"DDInter719"
] | Chenodeoxycholic acid | Fenofibric acid | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.[A32038,L128... | Moderate | 1 | [
[
[
780,
24,
1534
]
],
[
[
780,
63,
267
],
[
267,
24,
1534
]
],
[
[
780,
24,
1613
],
[
1613,
24,
1534
]
],
[
[
780,
63,
126
],
[
126,
... | [
[
[
"Chenodeoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibric acid"
]
],
[
[
"Chenodeoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Fenofibric acid
Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken... |
DB00550 | DB00631 | 99 | 372 | [
"DDInter1541",
"DDInter405"
] | Propylthiouracil | Clofarabine | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Moderate | 1 | [
[
[
99,
24,
372
]
],
[
[
99,
7,
13720
],
[
13720,
46,
372
]
],
[
[
99,
7,
12149
],
[
12149,
57,
372
]
],
[
[
99,
18,
2183
],
[
2183,
... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
]
],
[
[
"Propylthiouracil",
"{u} (Compound) upregulates {v} (Gene)",
"TMEM2"
],
[
"TMEM2",
"{u} (Gene) is upregula... | Propylthiouracil (Compound) upregulates TMEM2 (Gene) and TMEM2 (Gene) is upregulated by Clofarabine (Compound)
Propylthiouracil (Compound) upregulates WRB (Gene) and WRB (Gene) is downregulated by Clofarabine (Compound)
Propylthiouracil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Clofarab... |
DB00222 | DB08907 | 245 | 1,344 | [
"DDInter825",
"DDInter280"
] | Glimepiride | Canagliflozin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
245,
24,
1344
]
],
[
[
245,
24,
549
],
[
549,
1,
1344
]
],
[
[
245,
21,
29013
],
[
29013,
60,
1344
]
],
[
[
245,
23,
1103
],
[
1103,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Glimepiride (Compound) causes Diabetes mellitus (Side Effect) and Diabetes mellitus (Side Effect) is caused by Canagliflozin (Compound)
Glimepiride ma... |
DB00467 | DB00959 | 1,467 | 1,486 | [
"DDInter644",
"DDInter1191"
] | Enoxacin | Methylprednisolone | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
1467,
25,
1486
]
],
[
[
1467,
25,
175
],
[
175,
40,
1486
]
],
[
[
1467,
25,
167
],
[
167,
1,
1486
]
],
[
[
1467,
64,
251
],
[
251,
... | [
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone",
... | Enoxacin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Enoxacin may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylprednisolone (Compound)
Enox... |
DB06081 | DB09068 | 1,046 | 1,427 | [
"DDInter286",
"DDInter1948"
] | Caplacizumab | Vortioxetine | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1046,
24,
1427
]
],
[
[
1046,
64,
25
],
[
25,
24,
1427
]
],
[
[
1046,
25,
256
],
[
256,
24,
1427
]
],
[
[
1046,
63,
477
],
[
477,
... | [
[
[
"Caplacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anistreplase"
],
[
"An... | Caplacizumab may lead to a major life threatening interaction when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Caplacizumab may lead to a major life threatening interaction when taken with Prasugrel and Prasugrel may cause a moder... |
DB00444 | DB09276 | 63 | 381 | [
"DDInter1765",
"DDInter1682"
] | Teniposide | Sodium aurothiomalate | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no valu... | Moderate | 1 | [
[
[
63,
24,
381
]
],
[
[
63,
24,
1683
],
[
1683,
24,
381
]
],
[
[
63,
63,
491
],
[
491,
24,
381
]
],
[
[
63,
23,
147
],
[
147,
24,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium aurothiomalate"
]
],
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
... | Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Sodium aurothiomalate
Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Peginter... |
DB00962 | DB11186 | 1,639 | 1,609 | [
"DDInter1957",
"DDInter1427"
] | Zaleplon | Pentoxyverine | Zaleplon is a sedative/hypnotic, mainly used for insomnia. It is known as a nonbenzodiazepine hypnotic. Zaleplon interacts with the GABA receptor complex and shares some of the pharmacological properties of the benzodiazepines. Zaleplon is a schedule IV drug in the United States. | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1639,
24,
1609
]
],
[
[
1639,
24,
649
],
[
649,
24,
1609
]
],
[
[
1639,
63,
506
],
[
506,
24,
1609
]
],
[
[
1639,
64,
475
],
[
475,
... | [
[
[
"Zaleplon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Zaleplon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Zaleplon may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and D... |
DB01166 | DB12141 | 477 | 971 | [
"DDInter379",
"DDInter817"
] | Cilostazol | Gilteritinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
477,
24,
971
]
],
[
[
477,
62,
1247
],
[
1247,
23,
971
]
],
[
[
477,
63,
485
],
[
485,
24,
971
]
],
[
[
477,
24,
730
],
[
730,
6... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Cilostazol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Cilostazol may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine... |
DB00774 | DB00816 | 1,577 | 1,674 | [
"DDInter889",
"DDInter1346"
] | Hydroflumethiazide | Orciprenaline | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1577,
24,
1674
]
],
[
[
1577,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
1577,
63,
251
],
[
251,
23,
1674
]
],
[
[
1577,
24,
891
],
[
891... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Hydroflumethiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (S... | Hydroflumethiazide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone may cause a minor interaction that can limit clinical effects ... |
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