drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01254 | DB15822 | 1,213 | 69 | [
"DDInter484",
"DDInter1504"
] | Dasatinib | Pralsetinib | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Pralsetinib, similar to the previously approved [selpercatinib], is a kinase inhibitor with enhanced specificity for RET tyrosine kinase receptors (RTKs) over other RTK classes.[A202055, A219751, L15986] Enhanced RET (Rearranged during transfection) oncogene expression is a hallmark of many cancers, including non-small... | Moderate | 1 | [
[
[
1213,
24,
69
]
],
[
[
1213,
24,
283
],
[
283,
24,
69
]
],
[
[
1213,
25,
985
],
[
985,
24,
69
]
],
[
[
1213,
63,
322
],
[
322,
24... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pralsetinib"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Pralsetinib
Dasatinib may lead to a major life threatening interaction when taken with Osimertinib and Osimertinib may cause... |
DB00072 | DB10276 | 550 | 1,624 | [
"DDInter1846",
"DDInter1623"
] | Trastuzumab | Rotavirus vaccine | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
550,
25,
1624
]
],
[
[
550,
25,
770
],
[
770,
25,
1624
]
],
[
[
550,
24,
973
],
[
973,
25,
1624
]
],
[
[
550,
24,
270
],
[
270,
... | [
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Trastuzumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
],
[
"Thalidomide",
... | Trastuzumab may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may lead to a major life threatening interaction when taken with Rotavirus vaccine
Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may lead to a ... |
DB00238 | DB00889 | 188 | 1,133 | [
"DDInter1285",
"DDInter840"
] | Nevirapine | Granisetron | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
188,
24,
1133
]
],
[
[
188,
6,
8374
],
[
8374,
45,
1133
]
],
[
[
188,
21,
28851
],
[
28851,
60,
1133
]
],
[
[
188,
24,
1213
],
[
1213,... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Nevirapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Granisetron (Compound)
Nevirapine (Compound) causes Hepatic enzyme increased (Side Effect) and Hepatic enzyme increased (Side Effect) is caused by Granisetron (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases whe... |
DB00514 | DB04908 | 506 | 1,671 | [
"DDInter527",
"DDInter741"
] | Dextromethorphan | Flibanserin | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
506,
24,
1671
]
],
[
[
506,
24,
741
],
[
741,
63,
1671
]
],
[
[
506,
24,
830
],
[
830,
24,
1671
]
],
[
[
506,
63,
1594
],
[
1594,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Pheninda... |
DB01238 | DB09472 | 673 | 1,383 | [
"DDInter118",
"DDInter1693"
] | Aripiprazole | Sodium sulfate | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
673,
24,
1383
]
],
[
[
673,
63,
678
],
[
678,
24,
1383
]
],
[
[
673,
64,
1311
],
[
1311,
24,
1383
]
],
[
[
673,
24,
1342
],
[
1342,
... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxamniquine"
],... | Aripiprazole may cause a moderate interaction that could exacerbate diseases when taken with Oxamniquine and Oxamniquine may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Aripiprazole may lead to a major life threatening interaction when taken with Metoclopramide and Metoclo... |
DB00218 | DB11901 | 1,176 | 913 | [
"DDInter1247",
"DDInter107"
] | Moxifloxacin | Apalutamide | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1176,
25,
913
]
],
[
[
1176,
23,
112
],
[
112,
23,
913
]
],
[
[
1176,
64,
600
],
[
600,
24,
913
]
],
[
[
1176,
24,
28
],
[
28,
2... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Moxifloxacin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole m... |
DB00582 | DB06595 | 1,622 | 1,491 | [
"DDInter1946",
"DDInter1214"
] | Voriconazole | Midostaurin | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Major | 2 | [
[
[
1622,
25,
1491
]
],
[
[
1622,
25,
1135
],
[
1135,
62,
1491
]
],
[
[
1622,
23,
112
],
[
112,
23,
1491
]
],
[
[
1622,
24,
761
],
[
761,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Midostaurin"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u... | Voriconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Voriconazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may c... |
DB00040 | DB00612 | 27 | 1,121 | [
"DDInter827",
"DDInter216"
] | Glucagon | Bisoprolol | Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Minor | 0 | [
[
[
27,
23,
1121
]
],
[
[
27,
23,
819
],
[
819,
40,
1121
]
],
[
[
27,
23,
819
],
[
819,
40,
236
],
[
236,
40,
1121
]
],
[
[
27,
23,
... | [
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bisoprolol"
]
],
[
[
"Glucagon",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
],
[
"Ace... | Glucagon may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Glucagon may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol (Compound) resembles Esmolol (Compound) and Esmolol... |
DB09054 | DB14443 | 384 | 987 | [
"DDInter905",
"DDInter1931"
] | Idelalisib | Vibrio cholerae CVD 103-HgR strain live antigen | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
384,
24,
987
]
],
[
[
384,
24,
1480
],
[
1480,
24,
987
]
],
[
[
384,
63,
141
],
[
141,
24,
987
]
],
[
[
384,
25,
351
],
[
351,
2... | [
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Idelalisib may cause a moderate interaction that could exacerbate diseases when... |
DB01157 | DB08913 | 304 | 1,186 | [
"DDInter1875",
"DDInter1561"
] | Trimetrexate | Radium Ra 223 dichloride | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
304,
24,
1186
]
],
[
[
304,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
304,
63,
372
],
[
372,
24,
1186
]
],
[
[
304,
24,
1362
],
[
1362,
... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Trimetrexate",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Eff... | Trimetrexate (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Trimetrexate may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when take... |
DB00470 | DB00960 | 530 | 887 | [
"DDInter601",
"DDInter1471"
] | Dronabinol | Pindolol | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Pindolol is a first generation non-selective beta blocker used in the treatment of hypertension. Early research into the use of pindolol found it had chronotropic effects, and so further investigation focused on the treatment of arrhythmia. Research into pindolol's use in the treatment of hypertension began in the earl... | Moderate | 1 | [
[
[
530,
24,
887
]
],
[
[
530,
24,
819
],
[
819,
40,
887
]
],
[
[
530,
63,
88
],
[
88,
40,
887
]
],
[
[
530,
24,
1121
],
[
1121,
1,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Pindolol (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Pindolol (Compound)
Dron... |
DB09043 | DB14731 | 135 | 1,518 | [
"DDInter36",
"DDInter1741"
] | Albiglutide | Tagraxofusp | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
135,
24,
1518
]
],
[
[
135,
63,
176
],
[
176,
24,
1518
]
],
[
[
135,
62,
1647
],
[
1647,
24,
1518
]
],
[
[
135,
24,
1296
],
[
1296,
... | [
[
[
"Albiglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Albiglutide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glargine"
],... | Albiglutide may cause a moderate interaction that could exacerbate diseases when taken with Insulin glargine and Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Albiglutide may cause a minor interaction that can limit clinical effects when taken with Acarbose... |
DB04953 | DB09082 | 495 | 659 | [
"DDInter708",
"DDInter1934"
] | Ezogabine | Vilanterol | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
495,
24,
659
]
],
[
[
495,
24,
927
],
[
927,
63,
659
]
],
[
[
495,
25,
1069
],
[
1069,
24,
659
]
],
[
[
495,
63,
222
],
[
222,
2... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
],
[
... | Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib and Encorafenib may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Ezogabine may lead to a major life threatening interaction when taken with Vandetanib and Vandetanib may cause ... |
DB01240 | DB04861 | 885 | 1,592 | [
"DDInter657",
"DDInter1271"
] | Epoprostenol | Nebivolol | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
885,
24,
1592
]
],
[
[
885,
21,
28762
],
[
28762,
60,
1592
]
],
[
[
885,
63,
1479
],
[
1479,
23,
1592
]
],
[
[
885,
24,
578
],
[
578,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Epoprostenol",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cau... | Epoprostenol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Nebivolol (Compound)
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when... |
DB00341 | DB00402 | 1,242 | 1,407 | [
"DDInter343",
"DDInter685"
] | Cetirizine | Eszopiclone | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | Moderate | 1 | [
[
[
1242,
24,
1407
]
],
[
[
1242,
7,
5415
],
[
5415,
57,
1407
]
],
[
[
1242,
21,
28936
],
[
28936,
60,
1407
]
],
[
[
1242,
24,
1264
],
[
1... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eszopiclone"
]
],
[
[
"Cetirizine",
"{u} (Compound) upregulates {v} (Gene)",
"UBQLN2"
],
[
"UBQLN2",
"{u} (Gene) is downregulated by {... | Cetirizine (Compound) upregulates UBQLN2 (Gene) and UBQLN2 (Gene) is downregulated by Eszopiclone (Compound)
Cetirizine (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Eszopiclone (Compound)
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00812 | DB08880 | 998 | 1,510 | [
"DDInter1451",
"DDInter1771"
] | Phenylbutazone | Teriflunomide | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
998,
25,
1510
]
],
[
[
998,
62,
608
],
[
608,
23,
1510
]
],
[
[
998,
24,
129
],
[
129,
63,
1510
]
],
[
[
998,
63,
1144
],
[
1144,
... | [
[
[
"Phenylbutazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Phenylbutazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
"Li... | Phenylbutazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Phenylbutazone may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and... |
DB00424 | DB11160 | 19 | 337 | [
"DDInter896",
"DDInter1459"
] | Hyoscyamine | Phenyltoloxamine | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
19,
24,
337
]
],
[
[
19,
24,
820
],
[
820,
24,
337
]
],
[
[
19,
63,
999
],
[
999,
24,
337
]
],
[
[
19,
74,
1089
],
[
1089,
24,
... | [
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Hyoscyamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],... | Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylper... |
DB10583 | DB12001 | 949 | 564 | [
"DDInter415",
"DDInter7"
] | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Abemaciclib | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
949,
24,
564
]
],
[
[
949,
63,
58
],
[
58,
24,
564
]
],
[
[
949,
24,
351
],
[
351,
24,
564
]
],
[
[
949,
24,
1476
],
[
1476,
63,... | [
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderat... | Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Clostridium tetani toxoid antigen (formaldehyde inactivated) ma... |
DB09128 | DB12332 | 1,241 | 1,619 | [
"DDInter231",
"DDInter1626"
] | Brexpiprazole | Rucaparib | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
1241,
25,
1619
]
],
[
[
1241,
63,
222
],
[
222,
23,
1619
]
],
[
[
1241,
24,
1662
],
[
1662,
24,
1619
]
],
[
[
1241,
64,
1419
],
[
1419... | [
[
[
"Brexpiprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Brexpiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibu... | Brexpiprazole may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Brexpiprazole may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric aci... |
DB00529 | DB01250 | 789 | 712 | [
"DDInter779",
"DDInter1334"
] | Foscarnet | Olsalazine | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
789,
24,
712
]
],
[
[
789,
24,
50
],
[
50,
40,
712
]
],
[
[
789,
25,
416
],
[
416,
24,
712
]
],
[
[
789,
24,
1272
],
[
1272,
24,... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
[
... | Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Foscarnet may lead to a major life threatening interaction when taken with Kanamycin and Kanamycin may cause a moderate interaction that could exacerbate d... |
DB00927 | DB14881 | 1,559 | 180 | [
"DDInter712",
"DDInter1329"
] | Famotidine | Oliceridine | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
1559,
24,
180
]
],
[
[
1559,
62,
112
],
[
112,
23,
180
]
],
[
[
1559,
24,
401
],
[
401,
24,
180
]
],
[
[
1559,
63,
618
],
[
618,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and P... |
DB01285 | DB09263 | 708 | 1,436 | [
"DDInter445",
"DDInter1399"
] | Corticotropin | Patiromer | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Moderate | 1 | [
[
[
708,
24,
1436
]
],
[
[
708,
63,
1645
],
[
1645,
24,
1436
]
],
[
[
708,
24,
603
],
[
603,
63,
1436
]
],
[
[
708,
24,
286
],
[
286,
... | [
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Patiromer"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Patiromer
Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate ... |
DB00754 | DB01114 | 157 | 272 | [
"DDInter696",
"DDInter362"
] | Ethotoin | Chlorpheniramine | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
157,
24,
272
]
],
[
[
157,
24,
849
],
[
849,
63,
272
]
],
[
[
157,
63,
128
],
[
128,
24,
272
]
],
[
[
157,
21,
28722
],
[
28722,
... | [
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Ethotoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Ethotoin may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine ... |
DB01030 | DB10989 | 869 | 496 | [
"DDInter1835",
"DDInter858"
] | Topotecan | Hepatitis A Vaccine | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
869,
24,
496
]
],
[
[
869,
24,
4
],
[
4,
24,
496
]
],
[
[
869,
63,
147
],
[
147,
24,
496
]
],
[
[
869,
24,
738
],
[
738,
63,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucc... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Topotecan may cause a moderate interaction that could exacerbate diseases ... |
DB00902 | DB01364 | 104 | 22 | [
"DDInter1168",
"DDInter650"
] | Methdilazine | Ephedrine | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
104,
24,
22
]
],
[
[
104,
63,
80
],
[
80,
24,
22
]
],
[
[
104,
24,
1529
],
[
1529,
63,
22
]
],
[
[
104,
63,
475
],
[
475,
23,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetamine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Metamfetamine an... |
DB00491 | DB01320 | 127 | 651 | [
"DDInter1217",
"DDInter783"
] | Miglitol | Fosphenytoin | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
127,
24,
651
]
],
[
[
127,
63,
362
],
[
362,
1,
651
]
],
[
[
127,
21,
28731
],
[
28731,
60,
651
]
],
[
[
127,
63,
590
],
[
590,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Miglitol (Compound) causes Ileus (Side Effect) and Ileus (Side Effect) is caused by Fosphenytoin (Compound)
Miglitol may cause a moderate interaction that could e... |
DB00384 | DB00863 | 1,275 | 1,194 | [
"DDInter1859",
"DDInter1568"
] | Triamterene | Ranitidine | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Minor | 0 | [
[
[
1275,
23,
1194
]
],
[
[
1275,
23,
1127
],
[
1127,
1,
1194
]
],
[
[
1275,
6,
7950
],
[
7950,
45,
1194
]
],
[
[
1275,
21,
28658
],
[
286... | [
[
[
"Triamterene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
]
],
[
[
"Triamterene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nizatidine"
],
[
... | Triamterene may cause a minor interaction that can limit clinical effects when taken with Nizatidine and Nizatidine (Compound) resembles Ranitidine (Compound)
Triamterene (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Ranitidine (Compound)
Triamterene (Compound) causes Vomiting (Side Effect) and Vomiting ... |
DB00959 | DB06168 | 1,486 | 1,531 | [
"DDInter1191",
"DDInter281"
] | Methylprednisolone | Canakinumab | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
1486,
24,
1531
]
],
[
[
1486,
23,
1193
],
[
1193,
62,
1531
]
],
[
[
1486,
62,
1461
],
[
1461,
23,
1531
]
],
[
[
1486,
62,
523
],
[
523... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Methylprednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc glucona... | Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Vi... |
DB01044 | DB09043 | 246 | 135 | [
"DDInter809",
"DDInter36"
] | Gatifloxacin | Albiglutide | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Major | 2 | [
[
[
246,
25,
135
]
],
[
[
246,
64,
126
],
[
126,
23,
135
]
],
[
[
246,
40,
739
],
[
739,
24,
135
]
],
[
[
246,
64,
870
],
[
870,
24,... | [
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Albiglutide"
]
],
[
[
"Gatifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
],
[
"Warfarin",
"{u} ... | Gatifloxacin may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Gatifloxacin (Compound) resembles Lomefloxacin (Compound) and Lomefloxacin may cause a moderate interaction that could exacerbate ... |
DB00631 | DB08913 | 372 | 1,186 | [
"DDInter405",
"DDInter1561"
] | Clofarabine | Radium Ra 223 dichloride | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
372,
24,
1186
]
],
[
[
372,
21,
28722
],
[
28722,
60,
1186
]
],
[
[
372,
24,
37
],
[
37,
24,
1186
]
],
[
[
372,
63,
134
],
[
134,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Clofarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effec... | Clofarabine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00831 | DB11718 | 1,178 | 927 | [
"DDInter1866",
"DDInter640"
] | Trifluoperazine | Encorafenib | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
1178,
24,
927
]
],
[
[
1178,
23,
112
],
[
112,
23,
927
]
],
[
[
1178,
24,
720
],
[
720,
24,
927
]
],
[
[
1178,
1,
216
],
[
216,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Trifluoperazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
... | Trifluoperazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Mineral ... |
DB01181 | DB09498 | 1,532 | 810 | [
"DDInter906",
"DDInter1715"
] | Ifosfamide | Strontium chloride Sr-89 | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1532,
24,
810
]
],
[
[
1532,
63,
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],
[
552,
24,
810
]
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[
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1362
],
[
1362,
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]
],
[
[
1532,
24,
385
],
[
385,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Olapari... |
DB01235 | DB09104 | 1,191 | 286 | [
"DDInter1054",
"DDInter1118"
] | Levodopa | Magnesium hydroxide | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Minor | 0 | [
[
[
1191,
23,
286
]
],
[
[
1191,
24,
820
],
[
820,
23,
286
]
],
[
[
1191,
63,
401
],
[
401,
23,
286
]
],
[
[
1191,
24,
1593
],
[
1593,
... | [
[
[
"Levodopa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Levodopa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Levodopa may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and... |
DB00008 | DB00261 | 491 | 702 | [
"DDInter1407",
"DDInter93"
] | Peginterferon alfa-2a | Anagrelide | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Moderate | 1 | [
[
[
491,
24,
702
]
],
[
[
491,
24,
112
],
[
112,
62,
702
]
],
[
[
491,
24,
1031
],
[
1031,
63,
702
]
],
[
[
491,
24,
168
],
[
168,
2... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anagrelide"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metro... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Anagrelide
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00286 | DB00400 | 380 | 353 | [
"DDInter439",
"DDInter843"
] | Conjugated estrogens | Griseofulvin | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Moderate | 1 | [
[
[
380,
24,
353
]
],
[
[
380,
6,
8374
],
[
8374,
45,
353
]
],
[
[
380,
21,
28745
],
[
28745,
60,
353
]
],
[
[
380,
24,
1101
],
[
1101,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Griseofulvin"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bou... | Conjugated estrogens (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Griseofulvin (Compound)
Conjugated estrogens (Compound) causes Neuropathy peripheral (Side Effect) and Neuropathy peripheral (Side Effect) is caused by Griseofulvin (Compound)
Conjugated estrogens may cause a moderate interaction that cou... |
DB04948 | DB09020 | 1,084 | 28 | [
"DDInter1083",
"DDInter212"
] | Lofexidine | Bisacodyl | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1084,
24,
28
]
],
[
[
1084,
63,
662
],
[
662,
1,
28
]
],
[
[
1084,
63,
128
],
[
128,
40,
28
]
],
[
[
1084,
24,
823
],
[
823,
63,... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles B... |
DB01105 | DB08912 | 222 | 1,040 | [
"DDInter1665",
"DDInter462"
] | Sibutramine | Dabrafenib | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
222,
24,
1040
]
],
[
[
222,
6,
8374
],
[
8374,
45,
1040
]
],
[
[
222,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
222,
24,
478
],
[
478,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Sibutramine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Sibutramine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dabrafenib (Compound)
Sibutramine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Niloti... |
DB00380 | DB14711 | 145 | 779 | [
"DDInter522",
"DDInter1680"
] | Dexrazoxane | Smallpox (Vaccinia) Vaccine, Live | An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug ... | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
145,
25,
779
]
],
[
[
145,
24,
713
],
[
713,
25,
779
]
],
[
[
145,
6,
3930
],
[
3930,
45,
51
],
[
51,
25,
779
]
],
[
[
145,
24,
... | [
[
[
"Dexrazoxane",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Dexrazoxane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate... | Dexrazoxane may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Dexrazoxane (Compound) binds TOP2B (Gene) and TOP2B (Gene) is bound by Daunorubicin (Comp... |
DB00005 | DB00307 | 1,057 | 1,101 | [
"DDInter687",
"DDInter202"
] | Etanercept | Bexarotene | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Major | 2 | [
[
[
1057,
25,
1101
]
],
[
[
1057,
24,
608
],
[
608,
23,
1101
]
],
[
[
1057,
24,
597
],
[
597,
62,
1101
]
],
[
[
1057,
25,
1419
],
[
1419,
... | [
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bexarotene"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[
"Lidocaine",... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chlor... |
DB00431 | DB00827 | 1,503 | 646 | [
"DDInter1072",
"DDInter383"
] | Lindane | Cinoxacin | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Synthetic antimicrobial related to oxolinic acid and nalidixic acid and used in urinary tract infections. | Moderate | 1 | [
[
[
1503,
24,
646
]
],
[
[
1503,
21,
29232
],
[
29232,
60,
646
]
],
[
[
1503,
63,
1648
],
[
1648,
23,
646
]
],
[
[
1503,
63,
1031
],
[
103... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cinoxacin"
]
],
[
[
"Lindane",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is caused by {... | Lindane (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Cinoxacin (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a minor interaction that can limit clinical effects when taken with Cinoxacin
Lind... |
DB00580 | DB08870 | 311 | 850 | [
"DDInter1910",
"DDInter228"
] | Valdecoxib | Brentuximab vedotin | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
311,
24,
850
]
],
[
[
311,
24,
267
],
[
267,
24,
850
]
],
[
[
311,
24,
1033
],
[
1033,
63,
850
]
],
[
[
311,
63,
245
],
[
245,
2... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib an... |
DB01100 | DB09104 | 1,568 | 286 | [
"DDInter1470",
"DDInter1118"
] | Pimozide | Magnesium hydroxide | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1568,
24,
286
]
],
[
[
1568,
25,
820
],
[
820,
23,
286
]
],
[
[
1568,
64,
401
],
[
401,
23,
286
]
],
[
[
1568,
63,
104
],
[
104,
... | [
[
[
"Pimozide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
"Alim... | Pimozide may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Pimozide may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a mino... |
DB00981 | DB09488 | 1,528 | 103 | [
"DDInter1462",
"DDInter23"
] | Physostigmine | Acrivastine | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Moderate | 1 | [
[
[
1528,
24,
103
]
],
[
[
1528,
63,
1405
],
[
1405,
24,
103
]
],
[
[
1528,
24,
1443
],
[
1443,
24,
103
]
],
[
[
1528,
24,
1536
],
[
1536,... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acrivastine"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Dime... |
DB00005 | DB00708 | 1,057 | 1,454 | [
"DDInter687",
"DDInter1718"
] | Etanercept | Sufentanil | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
1057,
24,
1454
]
],
[
[
1057,
24,
704
],
[
704,
40,
1454
]
],
[
[
1057,
25,
1093
],
[
1093,
63,
1454
]
],
[
[
1057,
25,
1101
],
[
1101... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Etanercept may lead to a major life threatening interaction when taken with Ixekizumab and Ixekizumab may cause a moderate interaction that could exacerbate disease... |
DB00631 | DB11952 | 372 | 800 | [
"DDInter405",
"DDInter612"
] | Clofarabine | Duvelisib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
372,
24,
800
]
],
[
[
372,
24,
467
],
[
467,
24,
800
]
],
[
[
372,
24,
1476
],
[
1476,
63,
800
]
],
[
[
372,
63,
663
],
[
663,
2... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Bri... |
DB11901 | DB12301 | 913 | 907 | [
"DDInter107",
"DDInter585"
] | Apalutamide | Doravirine | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Major | 2 | [
[
[
913,
25,
907
]
],
[
[
913,
64,
1478
],
[
1478,
23,
907
]
],
[
[
913,
25,
159
],
[
159,
62,
907
]
],
[
[
913,
63,
392
],
[
392,
2... | [
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doravirine"
]
],
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Ivacaftor",
"{u} m... | Apalutamide may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Apalutamide may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a minor int... |
DB00059 | DB06335 | 1,560 | 761 | [
"DDInter1404",
"DDInter1646"
] | Pegaspargase | Saxagliptin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1560,
24,
761
]
],
[
[
1560,
24,
1573
],
[
1573,
24,
761
]
],
[
[
1560,
24,
1296
],
[
1296,
63,
761
]
],
[
[
1560,
63,
1179
],
[
1179,... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec... |
DB00627 | DB08907 | 265 | 1,344 | [
"DDInter1286",
"DDInter280"
] | Niacin | Canagliflozin | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
265,
24,
1344
]
],
[
[
265,
24,
549
],
[
549,
1,
1344
]
],
[
[
265,
21,
29013
],
[
29013,
60,
1344
]
],
[
[
265,
63,
176
],
[
176,
... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
[
... | Niacin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Niacin (Compound) causes Diabetes mellitus (Side Effect) and Diabetes mellitus (Side Effect) is caused by Canagliflozin (Compound)
Niacin may cause a moder... |
DB06674 | DB09237 | 908 | 1,586 | [
"DDInter837",
"DDInter1045"
] | Golimumab | Levamlodipine | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
908,
24,
1586
]
],
[
[
908,
64,
1648
],
[
1648,
24,
1586
]
],
[
[
908,
25,
384
],
[
384,
24,
1586
]
],
[
[
908,
25,
405
],
[
405,
... | [
[
[
"Golimumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aldesleukin"
],
[
"Aldesleu... | Golimumab may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Levamlodipine
Golimumab may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate i... |
DB00041 | DB08827 | 1,648 | 990 | [
"DDInter38",
"DDInter1085"
] | Aldesleukin | Lomitapide | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1648,
25,
990
]
],
[
[
1648,
24,
1362
],
[
1362,
63,
990
]
],
[
[
1648,
24,
77
],
[
77,
24,
990
]
],
[
[
1648,
25,
147
],
[
147,
... | [
[
[
"Aldesleukin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
],
[
"Olaparib",... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Idarubicin and Idarubic... |
DB00782 | DB01359 | 1,123 | 729 | [
"DDInter1535",
"DDInter1417"
] | Propantheline | Penbutolol | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
1123,
24,
729
]
],
[
[
1123,
63,
461
],
[
461,
1,
729
]
],
[
[
1123,
24,
699
],
[
699,
40,
729
]
],
[
[
1123,
21,
28698
],
[
28698,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Propan... |
DB00910 | DB01320 | 1,041 | 651 | [
"DDInter1394",
"DDInter783"
] | Paricalcitol | Fosphenytoin | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
1041,
24,
651
]
],
[
[
1041,
63,
362
],
[
362,
1,
651
]
],
[
[
1041,
6,
8374
],
[
8374,
45,
651
]
],
[
[
1041,
21,
28691
],
[
28691,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Paricalcitol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosphenytoin (Compound)
Paricalcitol (Compound) causes Somnolence (Side Effect) and ... |
DB00227 | DB09272 | 1,463 | 412 | [
"DDInter1098",
"DDInter632"
] | Lovastatin | Eluxadoline | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
1463,
24,
412
]
],
[
[
1463,
35,
467
],
[
467,
24,
412
]
],
[
[
1463,
25,
384
],
[
384,
24,
412
]
],
[
[
1463,
24,
14
],
[
14,
2... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Lovastatin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken ... | Lovastatin (Compound) resembles Simvastatin (Compound) and Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Lovastatin may lead to a major life threatening in... |
DB00218 | DB12245 | 1,176 | 823 | [
"DDInter1247",
"DDInter1863"
] | Moxifloxacin | Triclabendazole | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Major | 2 | [
[
[
1176,
25,
823
]
],
[
[
1176,
23,
112
],
[
112,
23,
823
]
],
[
[
1176,
25,
1010
],
[
1010,
24,
823
]
],
[
[
1176,
24,
28
],
[
28,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Moxifloxacin may lead to a major life threatening interaction when taken with Mefloquine and Mefloquine... |
DB00489 | DB00945 | 17 | 1,479 | [
"DDInter1704",
"DDInter20"
] | Sotalol | Acetylsalicylic acid | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Minor | 0 | [
[
[
17,
23,
1479
]
],
[
[
17,
21,
28931
],
[
28931,
60,
1479
]
],
[
[
17,
1,
88
],
[
88,
23,
1479
]
],
[
[
17,
23,
1283
],
[
1283,
6... | [
[
[
"Sotalol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Sotalol",
"{u} (Compound) causes {v} (Side Effect)",
"Haemorrhage"
],
[
"Haemorrhage",
"{u} (Side Effect) i... | Sotalol (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Acetylsalicylic acid (Compound)
Sotalol (Compound) resembles Metoprolol (Compound) and Metoprolol may cause a minor interaction that can limit clinical effects when taken with Acetylsalicylic acid
Sotalol may cause a minor in... |
DB00451 | DB00881 | 542 | 954 | [
"DDInter1064",
"DDInter1554"
] | Levothyroxine | Quinapril | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
542,
24,
954
]
],
[
[
542,
23,
1523
],
[
1523,
40,
954
]
],
[
[
542,
21,
28900
],
[
28900,
60,
954
]
],
[
[
542,
24,
286
],
[
286,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Labetalol"
],
[
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Labetalol and Labetalol (Compound) resembles Quinapril (Compound)
Levothyroxine (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Quinapril (Compound)
Levothyroxine may cause a moderate... |
DB00876 | DB01143 | 1,414 | 923 | [
"DDInter658",
"DDInter65"
] | Eprosartan | Amifostine | Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced. | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1414,
24,
923
]
],
[
[
1414,
21,
28642
],
[
28642,
60,
923
]
],
[
[
1414,
24,
714
],
[
714,
24,
923
]
],
[
[
1414,
1,
240
],
[
240,
... | [
[
[
"Eprosartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Eprosartan",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v... | Eprosartan (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Eprosartan may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Eprosart... |
DB11979 | DB15035 | 1,320 | 503 | [
"DDInter625",
"DDInter1959"
] | Elagolix | Zanubrutinib | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Moderate | 1 | [
[
[
1320,
24,
503
]
],
[
[
1320,
63,
1094
],
[
1094,
24,
503
]
],
[
[
1320,
24,
982
],
[
982,
24,
503
]
],
[
[
1320,
63,
39
],
[
39,
... | [
[
[
"Elagolix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Elagolix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
],
[
... | Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Elagolix may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosid... |
DB00222 | DB00647 | 245 | 675 | [
"DDInter825",
"DDInter528"
] | Glimepiride | Dextropropoxyphene | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Moderate | 1 | [
[
[
245,
24,
675
]
],
[
[
245,
24,
494
],
[
494,
1,
675
]
],
[
[
245,
24,
954
],
[
954,
40,
675
]
],
[
[
245,
24,
820
],
[
820,
64,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Disopyramide"
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Disopyramide and Disopyramide (Compound) resembles Dextropropoxyphene (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Dextroprop... |
DB01128 | DB01267 | 918 | 519 | [
"DDInter204",
"DDInter1381"
] | Bicalutamide | Paliperidone | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
918,
24,
519
]
],
[
[
918,
63,
1664
],
[
1664,
1,
519
]
],
[
[
918,
25,
924
],
[
924,
1,
519
]
],
[
[
918,
6,
12523
],
[
12523,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Bicalutamide may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Compound)
Bic... |
DB00851 | DB10276 | 611 | 1,624 | [
"DDInter463",
"DDInter1623"
] | Dacarbazine | Rotavirus vaccine | An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
611,
25,
1624
]
],
[
[
611,
63,
552
],
[
552,
25,
1624
]
],
[
[
611,
24,
1307
],
[
1307,
25,
1624
]
],
[
[
611,
64,
1648
],
[
1648,
... | [
[
[
"Dacarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Dacarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
],
[
"C... | Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may lead to a major life threatening interaction when taken with Rotavirus vaccine
Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphalan may... |
DB01073 | DB09570 | 1,488 | 1,480 | [
"DDInter745",
"DDInter1002"
] | Fludarabine | Ixazomib | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
1488,
24,
1480
]
],
[
[
1488,
24,
987
],
[
987,
63,
1480
]
],
[
[
1488,
63,
440
],
[
440,
24,
1480
]
],
[
[
1488,
24,
248
],
[
248,
... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen and Vibrio cholerae CVD 103-HgR strain live antigen may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Fludarabine may cause a moderate intera... |
DB00220 | DB04868 | 798 | 478 | [
"DDInter1276",
"DDInter1293"
] | Nelfinavir | Nilotinib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
798,
25,
478
]
],
[
[
798,
25,
1468
],
[
1468,
63,
478
]
],
[
[
798,
6,
6017
],
[
6017,
45,
478
]
],
[
[
798,
7,
6717
],
[
6717,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} may ... | Nelfinavir may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Nelfinavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Nelfinavir (Compound) upregulates HER... |
DB01088 | DB04861 | 714 | 1,592 | [
"DDInter908",
"DDInter1271"
] | Iloprost | Nebivolol | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
714,
24,
1592
]
],
[
[
714,
63,
1479
],
[
1479,
23,
1592
]
],
[
[
714,
24,
578
],
[
578,
62,
1592
]
],
[
[
714,
24,
1450
],
[
1450,
... | [
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Iloprost",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
... | Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Nebivolol
Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Ticagrel... |
DB00637 | DB09020 | 1,557 | 28 | [
"DDInter128",
"DDInter212"
] | Astemizole | Bisacodyl | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1557,
24,
28
]
],
[
[
1557,
7,
7647
],
[
7647,
46,
28
]
],
[
[
1557,
18,
2049
],
[
2049,
57,
28
]
],
[
[
1557,
7,
5509
],
[
5509,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Astemizole",
"{u} (Compound) upregulates {v} (Gene)",
"NPC1"
],
[
"NPC1",
"{u} (Gene) is upregulated by {v} (Comp... | Astemizole (Compound) upregulates NPC1 (Gene) and NPC1 (Gene) is upregulated by Bisacodyl (Compound)
Astemizole (Compound) downregulates MRPS16 (Gene) and MRPS16 (Gene) is downregulated by Bisacodyl (Compound)
Astemizole (Compound) upregulates FDFT1 (Gene) and FDFT1 (Gene) is downregulated by Bisacodyl (Compound)
Astem... |
DB06290 | DB12941 | 1,449 | 466 | [
"DDInter1673",
"DDInter481"
] | Simeprevir | Darolutamide | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1449,
24,
466
]
],
[
[
1449,
64,
600
],
[
600,
23,
466
]
],
[
[
1449,
25,
283
],
[
283,
23,
466
]
],
[
[
1449,
24,
484
],
[
484,
... | [
[
[
"Simeprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Simeprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Flucona... | Simeprevir may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Simeprevir may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a minor inter... |
DB00327 | DB00366 | 421 | 1,594 | [
"DDInter890",
"DDInter600"
] | Hydromorphone | Doxylamine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Moderate | 1 | [
[
[
421,
24,
1594
]
],
[
[
421,
24,
662
],
[
662,
63,
1594
]
],
[
[
421,
21,
28709
],
[
28709,
60,
1594
]
],
[
[
421,
1,
314
],
[
314,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine
Hydromorphone (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) i... |
DB00069 | DB08827 | 367 | 990 | [
"DDInter946",
"DDInter1085"
] | Interferon alfacon-1 | Lomitapide | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
367,
25,
990
]
],
[
[
367,
24,
973
],
[
973,
24,
990
]
],
[
[
367,
24,
1362
],
[
1362,
63,
990
]
],
[
[
367,
63,
268
],
[
268,
2... | [
[
[
"Interferon alfacon-1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
],
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel and Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Lomitapide
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with O... |
DB01254 | DB04844 | 1,213 | 843 | [
"DDInter484",
"DDInter1778"
] | Dasatinib | Tetrabenazine | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Moderate | 1 | [
[
[
1213,
24,
843
]
],
[
[
1213,
62,
479
],
[
479,
40,
843
]
],
[
[
1213,
7,
10439
],
[
10439,
46,
843
]
],
[
[
1213,
18,
3771
],
[
3771,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetrabenazine"
]
],
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Donepezil"
],
[
... | Dasatinib may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezil (Compound) resembles Tetrabenazine (Compound)
Dasatinib (Compound) upregulates PROS1 (Gene) and PROS1 (Gene) is upregulated by Tetrabenazine (Compound)
Dasatinib (Compound) downregulates SUV39H1 (Gene) and SU... |
DB00026 | DB00853 | 1,184 | 1,686 | [
"DDInter94",
"DDInter1762"
] | Anakinra | Temozolomide | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alky... | Moderate | 1 | [
[
[
1184,
24,
1686
]
],
[
[
1184,
24,
970
],
[
970,
24,
1686
]
],
[
[
1184,
24,
1330
],
[
1330,
63,
1686
]
],
[
[
1184,
23,
1461
],
[
1461... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Temozolomide"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluorouracil"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil and Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Temozolomide
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab and Naxit... |
DB01097 | DB09330 | 1,377 | 985 | [
"DDInter1033",
"DDInter1352"
] | Leflunomide | Osimertinib | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1377,
25,
985
]
],
[
[
1377,
64,
168
],
[
168,
23,
985
]
],
[
[
1377,
63,
112
],
[
112,
23,
985
]
],
[
[
1377,
25,
1478
],
[
1478,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
"{u... | Leflunomide may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may... |
DB05679 | DB06603 | 1,683 | 39 | [
"DDInter1907",
"DDInter1387"
] | Ustekinumab | Panobinostat | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Moderate | 1 | [
[
[
1683,
24,
39
]
],
[
[
1683,
24,
221
],
[
221,
63,
39
]
],
[
[
1683,
63,
336
],
[
336,
24,
39
]
],
[
[
1683,
24,
259
],
[
259,
24... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Panobinostat"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antig... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Ustekinumab may cause a m... |
DB06636 | DB12010 | 1,623 | 214 | [
"DDInter980",
"DDInter785"
] | Isavuconazonium | Fostamatinib | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1623,
24,
214
]
],
[
[
1623,
24,
976
],
[
976,
24,
214
]
],
[
[
1623,
63,
723
],
[
723,
24,
214
]
],
[
[
1623,
64,
866
],
[
866,
... | [
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Isavuconazonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tofacitinib"
... | Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Isavuconazonium may cause a moderate interaction that could exacerbate diseases when taken with Aprepit... |
DB00443 | DB12130 | 251 | 1,017 | [
"DDInter195",
"DDInter1094"
] | Betamethasone | Lorlatinib | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
251,
24,
1017
]
],
[
[
251,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
251,
63,
590
],
[
590,
24,
1017
]
],
[
[
251,
1,
175
],
[
175,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and... |
DB00595 | DB11110 | 1,545 | 603 | [
"DDInter1374",
"DDInter1115"
] | Oxytetracycline | Magnesium citrate | A tetracycline analog isolated from the actinomycete streptomyces rimosus and used in a wide variety of clinical conditions. | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1545,
24,
603
]
],
[
[
1545,
62,
863
],
[
863,
24,
603
]
],
[
[
1545,
23,
1326
],
[
1326,
24,
603
]
],
[
[
1545,
24,
996
],
[
996,
... | [
[
[
"Oxytetracycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Oxytetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amiloride"
... | Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Amiloride and Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Oxytetracycline may cause a minor interaction that can limit clinical effects when taken with Diclofenam... |
DB06228 | DB10672 | 792 | 297 | [
"DDInter1609",
"DDInter417"
] | Rivaroxaban | Clove | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
792,
23,
297
]
],
[
[
792,
25,
235
],
[
235,
62,
297
]
],
[
[
792,
25,
578
],
[
578,
23,
297
]
],
[
[
792,
64,
1564
],
[
1564,
2... | [
[
[
"Rivaroxaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Rivaroxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Rivaroxaban may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Rivaroxaban may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a minor interaction th... |
DB00222 | DB08869 | 245 | 162 | [
"DDInter825",
"DDInter1773"
] | Glimepiride | Tesamorelin | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Tesamorelin is a stabilized synthetic peptide analogue of the hypothalamic peptide, Growth Hormone Releasing Hormone (GHRH) indicated for the reduction of excess abdominal fat in HIV-infected patients with lipodystrophy. Lipodystrophy is a metabolic condition characterized by insulin resistance, fat redistribution, and... | Moderate | 1 | [
[
[
245,
24,
162
]
],
[
[
245,
24,
170
],
[
170,
24,
162
]
],
[
[
245,
24,
1344
],
[
1344,
63,
162
]
],
[
[
245,
63,
1685
],
[
1685,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tesamorelin"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Tesamorelin
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin an... |
DB00398 | DB00994 | 79 | 361 | [
"DDInter1702",
"DDInter1277"
] | Sorafenib | Neomycin | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Moderate | 1 | [
[
[
79,
24,
361
]
],
[
[
79,
21,
28722
],
[
28722,
60,
361
]
],
[
[
79,
24,
355
],
[
355,
23,
361
]
],
[
[
79,
63,
1252
],
[
1252,
2... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neomycin"
]
],
[
[
"Sorafenib",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} ... | Sorafenib (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and Lactulose may cause a minor interaction that can limit clinical effects when taken with Neomycin
Sorafenib ma... |
DB00860 | DB11071 | 891 | 1,004 | [
"DDInter1513",
"DDInter1449"
] | Prednisolone | Phenyl salicylate | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
891,
24,
1004
]
],
[
[
891,
23,
771
],
[
771,
62,
1004
]
],
[
[
891,
24,
1411
],
[
1411,
24,
1004
]
],
[
[
891,
40,
1573
],
[
1573,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
... | Prednisolone may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase and Hyaluronidase may cause a minor interaction that can limit clinical effects when taken with Phenyl salicylate
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Tolbutam... |
DB08870 | DB11791 | 850 | 785 | [
"DDInter228",
"DDInter287"
] | Brentuximab vedotin | Capmatinib | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Capmatinib is a small molecule kinase inhibitor targeted against c-Met (a.k.a. hepatocyte growth factor receptor [HGFR]), a receptor tyrosine kinase that, in healthy humans, activates signaling cascades involved in organ regeneration and tissue repair. Aberrant c-Met activation - via mutations, amplification, and/or ov... | Moderate | 1 | [
[
[
850,
24,
785
]
],
[
[
850,
63,
1324
],
[
1324,
24,
785
]
],
[
[
850,
24,
868
],
[
868,
24,
785
]
],
[
[
850,
24,
1320
],
[
1320,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capmatinib"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitaz... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Capmatinib
Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00316 | DB09122 | 474 | 1,613 | [
"DDInter14",
"DDInter1409"
] | Acetaminophen | Peginterferon beta-1a | Acetaminophen (paracetamol), also commonly known as _Tylenol_, is the most commonly taken analgesic worldwide and is recommended as first-line therapy in pain conditions by the World Health Organization (WHO). It is also used for its antipyretic effects, helping to reduce fever. This drug was initially approved by the ... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
474,
24,
1613
]
],
[
[
474,
24,
267
],
[
267,
24,
1613
]
],
[
[
474,
63,
1560
],
[
1560,
24,
1613
]
],
[
[
474,
25,
1377
],
[
1377,
... | [
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Acetaminophen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone... | Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Acetaminophen may cause a moderate interaction that could exacerbate diseases when taken with Pega... |
DB03904 | DB09133 | 1,574 | 1,527 | [
"DDInter1903",
"DDInter965"
] | Urea | Iothalamic acid | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
1574,
24,
1527
]
],
[
[
1574,
23,
1399
],
[
1399,
64,
1527
]
],
[
[
1574,
24,
643
],
[
643,
63,
1274
],
[
1274,
25,
1527
]
],
[
[
1574... | [
[
[
"Urea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Urea",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lithium carbonate"
],
[
... | Urea may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate and Lithium carbonate may lead to a major life threatening interaction when taken with Iothalamic acid
Urea may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxi... |
DB01100 | DB01211 | 1,568 | 609 | [
"DDInter1470",
"DDInter393"
] | Pimozide | Clarithromycin | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Major | 2 | [
[
[
1568,
25,
609
]
],
[
[
1568,
6,
4973
],
[
4973,
45,
609
]
],
[
[
1568,
7,
8733
],
[
8733,
57,
609
]
],
[
[
1568,
18,
2183
],
[
2183,
... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Clarithro... | Pimozide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Pimozide (Compound) upregulates PHGDH (Gene) and PHGDH (Gene) is downregulated by Clarithromycin (Compound)
Pimozide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Clarithromycin (Compound)
Pimozide... |
DB00862 | DB01143 | 1,005 | 923 | [
"DDInter1918",
"DDInter65"
] | Vardenafil | Amifostine | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | Moderate | 1 | [
[
[
1005,
24,
923
]
],
[
[
1005,
21,
28642
],
[
28642,
60,
923
]
],
[
[
1005,
24,
714
],
[
714,
24,
923
]
],
[
[
1005,
63,
1214
],
[
1214,... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifostine"
]
],
[
[
"Vardenafil",
"{u} (Compound) causes {v} (Side Effect)",
"Shock"
],
[
"Shock",
"{u} (Side Effect) is caused by {v... | Vardenafil (Compound) causes Shock (Side Effect) and Shock (Side Effect) is caused by Amifostine (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Amifostine
Vardenaf... |
DB05273 | DB13915 | 507 | 689 | [
"DDInter1638",
"DDInter146"
] | Samarium (153Sm) lexidronam | Axicabtagene ciloleucel | Samarium Sm 153 lexidronam is a radioactive medication used to treat pain caused by cancer that has spread to the bone. It is a radiopharmaceutical. Radiopharmaceuticals are radioactive agents that may be used to diagnose some diseases by studying the function of the body's organs or to treat certain diseases.Samarium ... | Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. The drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. Once T-cells are collected from the patient, they are genetically engineered to express ant... | Major | 2 | [
[
[
507,
25,
689
]
],
[
[
507,
64,
599
],
[
599,
24,
689
]
],
[
[
507,
24,
270
],
[
270,
24,
689
]
],
[
[
507,
25,
738
],
[
738,
24,... | [
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axicabtagene ciloleucel"
]
],
[
[
"Samarium (153Sm) lexidronam",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alemtuzuma... | Samarium (153Sm) lexidronam may lead to a major life threatening interaction when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Axicabtagene ciloleucel
Samarium (153Sm) lexidronam may cause a moderate interaction that could exacerbate diseases whe... |
DB00086 | DB08875 | 1,167 | 1,618 | [
"DDInter1712",
"DDInter262"
] | Streptokinase | Cabozantinib | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1167,
25,
1618
]
],
[
[
1167,
24,
41
],
[
41,
63,
1618
]
],
[
[
1167,
24,
222
],
[
222,
24,
1618
]
],
[
[
1167,
24,
885
],
[
885,
... | [
[
[
"Streptokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
],
[
... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Sib... |
DB01072 | DB11730 | 915 | 351 | [
"DDInter129",
"DDInter1588"
] | Atazanavir | Ribociclib | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
915,
25,
351
]
],
[
[
915,
24,
466
],
[
466,
62,
351
]
],
[
[
915,
25,
283
],
[
283,
62,
351
]
],
[
[
915,
24,
310
],
[
310,
24,... | [
[
[
"Atazanavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Daroluta... | Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Atazanavir may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may caus... |
DB00054 | DB00945 | 1,432 | 1,479 | [
"DDInter6",
"DDInter20"
] | Abciximab | Acetylsalicylic acid | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1432,
24,
1479
]
],
[
[
1432,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
1432,
23,
297
],
[
297,
62,
1479
]
],
[
[
1432,
24,
557
],
[
557,
... | [
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Abciximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
... | Abciximab may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Abciximab may cause a minor interaction that can limit clinical effects when taken with C... |
DB00305 | DB00467 | 377 | 1,467 | [
"DDInter1232",
"DDInter644"
] | Mitomycin | Enoxacin | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Minor | 0 | [
[
[
377,
23,
1467
]
],
[
[
377,
23,
1539
],
[
1539,
40,
1467
]
],
[
[
377,
23,
1299
],
[
1299,
1,
1467
]
],
[
[
377,
62,
1176
],
[
1176,
... | [
[
[
"Mitomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Enoxacin"
]
],
[
[
"Mitomycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ofloxacin"
],
[
"Oflo... | Mitomycin may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) resembles Enoxacin (Compound)
Mitomycin may cause a minor interaction that can limit clinical effects when taken with Trovafloxacin and Trovafloxacin (Compound) resembles Enoxacin (Compound)
Mitomy... |
DB00197 | DB01023 | 1,324 | 409 | [
"DDInter1881",
"DDInter716"
] | Troglitazone | Felodipine | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Moderate | 1 | [
[
[
1324,
24,
409
]
],
[
[
1324,
24,
376
],
[
376,
40,
409
]
],
[
[
1324,
24,
578
],
[
578,
62,
409
]
],
[
[
1324,
24,
1017
],
[
1017,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Felodipine"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amlodipine"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Amlodipine and Amlodipine (Compound) resembles Felodipine (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can ... |
DB00938 | DB09065 | 455 | 760 | [
"DDInter1635",
"DDInter424"
] | Salmeterol | Cobicistat | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
455,
25,
760
]
],
[
[
455,
63,
1230
],
[
1230,
23,
760
]
],
[
[
455,
24,
1374
],
[
1374,
23,
760
]
],
[
[
455,
24,
938
],
[
938,
... | [
[
[
"Salmeterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
"Citalopram... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abirate... |
DB00604 | DB11837 | 1,425 | 1,297 | [
"DDInter385",
"DDInter1351"
] | Cisapride | Osilodrostat | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Major | 2 | [
[
[
1425,
25,
1297
]
],
[
[
1425,
23,
112
],
[
112,
23,
1297
]
],
[
[
1425,
24,
1288
],
[
1288,
24,
1297
]
],
[
[
1425,
25,
623
],
[
623,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osilodrostat"
]
],
[
[
"Cisapride",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Cisapride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Zileuton and Zileut... |
DB11834 | DB14443 | 1,303 | 987 | [
"DDInter849",
"DDInter1931"
] | Guselkumab | Vibrio cholerae CVD 103-HgR strain live antigen | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation. In clinical trials, guselkumab demonstrat... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1303,
24,
987
]
],
[
[
1303,
63,
259
],
[
259,
24,
987
]
],
[
[
1303,
64,
581
],
[
581,
24,
987
]
],
[
[
1303,
25,
676
],
[
676,
... | [
[
[
"Guselkumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Guselkumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Guselkumab may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Guselkumab may lead to a major life threatening interaction when taken with... |
DB00675 | DB11901 | 888 | 913 | [
"DDInter1744",
"DDInter107"
] | Tamoxifen | Apalutamide | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
888,
24,
913
]
],
[
[
888,
23,
112
],
[
112,
23,
913
]
],
[
[
888,
25,
271
],
[
271,
23,
913
]
],
[
[
888,
25,
279
],
[
279,
24,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Tamoxifen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Tamoxifen may lead to a major life threatening interaction when taken with Mirabegron and Mirabegron may cause... |
DB00065 | DB01181 | 581 | 1,532 | [
"DDInter923",
"DDInter906"
] | Infliximab | Ifosfamide | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Major | 2 | [
[
[
581,
25,
1532
]
],
[
[
581,
64,
1648
],
[
1648,
24,
1532
]
],
[
[
581,
25,
1330
],
[
1330,
63,
1532
]
],
[
[
581,
25,
0
],
[
0,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ifosfamide"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aldesleukin"
],
[
"Aldesleukin",
"{u}... | Infliximab may lead to a major life threatening interaction when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide
Infliximab may lead to a major life threatening interaction when taken with Naxitamab and Naxitamab may cause a moderate inte... |
DB06626 | DB08886 | 263 | 637 | [
"DDInter147",
"DDInter126"
] | Axitinib | Asparaginase Erwinia chrysanthemi | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
263,
24,
637
]
],
[
[
263,
63,
392
],
[
392,
24,
637
]
],
[
[
263,
64,
1220
],
[
1220,
24,
637
]
],
[
[
263,
24,
850
],
[
850,
2... | [
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Axitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatini... | Axitinib may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Axitinib may lead to a major life threatening interaction when taken with Dexamethasone and D... |
DB00907 | DB06717 | 290 | 875 | [
"DDInter427",
"DDInter778"
] | Cocaine (topical) | Fosaprepitant | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
290,
24,
875
]
],
[
[
290,
21,
28681
],
[
28681,
60,
875
]
],
[
[
290,
63,
629
],
[
629,
24,
875
]
],
[
[
290,
24,
1478
],
[
1478,
... | [
[
[
"Cocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Cocaine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effe... | Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Fosaprepitant
Cocaine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Fosaprepitant (Compound)
Cocaine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB01030 | DB14731 | 869 | 1,518 | [
"DDInter1835",
"DDInter1741"
] | Topotecan | Tagraxofusp | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Tagraxofusp is a CD123-directed cytotoxin. It is a fusion protein composed of a human interleukin-3 (IL-3) that is genetically fused to the catalytic and translocation domains of truncated diphtheria toxin (DT) produced in _Escherichia coli_.[A253762, A253887, L43702] Tagraxofusp received its first global approval by t... | Moderate | 1 | [
[
[
869,
24,
1518
]
],
[
[
869,
63,
372
],
[
372,
24,
1518
]
],
[
[
869,
24,
850
],
[
850,
24,
1518
]
],
[
[
869,
24,
990
],
[
990,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tagraxofusp"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofarabine"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Tagraxofusp
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin ... |
DB00543 | DB11963 | 87 | 1,045 | [
"DDInter82",
"DDInter465"
] | Amoxapine | Dacomitinib | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
87,
24,
1045
]
],
[
[
87,
25,
1039
],
[
1039,
24,
1045
]
],
[
[
87,
24,
1376
],
[
1376,
24,
1045
]
],
[
[
87,
1,
695
],
[
695,
2... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Amoxapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"Dexfen... | Amoxapine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenh... |
DB00046 | DB08822 | 1,179 | 911 | [
"DDInter940",
"DDInter156"
] | Insulin lispro | Azilsartan medoxomil | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Azilsartan medoxomil is a prodrug that is broken down to azilsartan, which belongs in the angiotensin-receptor blocking (ARB) drug class. It is a selective AT1 subtype angiotensin II receptor antagonist. Azilsartan medoxomil is a relatively recently-developed antihypertensive drug that was first approved by the FDA in ... | Moderate | 1 | [
[
[
1179,
24,
911
]
],
[
[
1179,
24,
217
],
[
217,
1,
911
]
],
[
[
1179,
24,
1450
],
[
1450,
63,
911
]
],
[
[
1179,
24,
549
],
[
549,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azilsartan medoxomil"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olmesarta... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Olmesartan and Olmesartan (Compound) resembles Azilsartan medoxomil (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderat... |
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