drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01005 | DB01138 | 995 | 804 | [
"DDInter894",
"DDInter1726"
] | Hydroxyurea | Sulfinpyrazone | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
995,
24,
804
]
],
[
[
995,
25,
976
],
[
976,
63,
804
]
],
[
[
995,
63,
1419
],
[
1419,
24,
804
]
],
[
[
995,
24,
738
],
[
738,
6... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Hydroxyurea",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tof... | Hydroxyurea may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Sulfinpyrazone
Hydroxyurea may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may ca... |
DB06212 | DB08881 | 165 | 868 | [
"DDInter1833",
"DDInter1925"
] | Tolvaptan | Vemurafenib | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
165,
24,
868
]
],
[
[
165,
6,
8374
],
[
8374,
45,
868
]
],
[
[
165,
21,
28714
],
[
28714,
60,
868
]
],
[
[
165,
23,
1135
],
[
1135,
... | [
[
[
"Tolvaptan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Tolvaptan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tolvaptan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Tolvaptan (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Vemurafenib (Compound)
Tolvaptan may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol ... |
DB00816 | DB08871 | 1,674 | 36 | [
"DDInter1346",
"DDInter666"
] | Orciprenaline | Eribulin | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1674,
24,
36
]
],
[
[
1674,
24,
519
],
[
519,
24,
36
]
],
[
[
1674,
63,
1424
],
[
1424,
24,
36
]
],
[
[
1674,
24,
180
],
[
180,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Q... |
DB00619 | DB01259 | 1,419 | 392 | [
"DDInter909",
"DDInter1024"
] | Imatinib | Lapatinib | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1419,
24,
392
]
],
[
[
1419,
6,
4973
],
[
4973,
45,
392
]
],
[
[
1419,
7,
3727
],
[
3727,
46,
392
]
],
[
[
1419,
21,
28674
],
[
28674,... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Imatinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Imatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Imatinib (Compound) upregulates MAL (Gene) and MAL (Gene) is upregulated by Lapatinib (Compound)
Imatinib (Compound) causes Nail disorder (Side Effect) and Nail disorder (Side Effect) is caused by Lapatinib (Compound)
Imatinib may ... |
DB01001 | DB01165 | 688 | 1,539 | [
"DDInter1632",
"DDInter1325"
] | Salbutamol | Ofloxacin | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Moderate | 1 | [
[
[
688,
24,
1539
]
],
[
[
688,
63,
1176
],
[
1176,
1,
1539
]
],
[
[
688,
24,
945
],
[
945,
40,
1539
]
],
[
[
688,
24,
246
],
[
246,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ofloxacin"
]
],
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Moxifloxacin"
],
[
... | Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Ofloxacin (Compound)
Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Ofloxacin (Comp... |
DB00227 | DB00641 | 1,463 | 467 | [
"DDInter1098",
"DDInter1675"
] | Lovastatin | Simvastatin | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
1463,
35,
467
]
],
[
[
1463,
5,
11596
],
[
11596,
44,
467
]
],
[
[
1463,
6,
5912
],
[
5912,
45,
467
]
],
[
[
1463,
7,
4634
],
[
4634,
... | [
[
[
"Lovastatin",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Lovastatin",
"{u} (Compound) treats {v} (Disease)",
"atherosclerosis"
],
[
... | Lovastatin (Compound) resembles Simvastatin (Compound) and
Lovastatin (Compound) treats atherosclerosis (Disease) and atherosclerosis (Disease) is treated by Simvastatin (Compound)
Lovastatin (Compound) binds ABCC2 (Gene) and ABCC2 (Gene) is bound by Simvastatin (Compound)
Lovastatin (Compound) upregulates FOXO4 (Gene)... |
DB00226 | DB00912 | 1,000 | 473 | [
"DDInter845",
"DDInter1581"
] | Guanadrel | Repaglinide | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1000,
24,
473
]
],
[
[
1000,
63,
73
],
[
73,
24,
473
]
],
[
[
1000,
24,
1148
],
[
1148,
63,
473
]
],
[
[
1000,
24,
251
],
[
251,
... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentermine"
],
[
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Iso... |
DB06663 | DB11901 | 1,154 | 913 | [
"DDInter1398",
"DDInter107"
] | Pasireotide | Apalutamide | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1154,
25,
913
]
],
[
[
1154,
62,
112
],
[
112,
23,
913
]
],
[
[
1154,
63,
608
],
[
608,
23,
913
]
],
[
[
1154,
64,
600
],
[
600,
... | [
[
[
"Pasireotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Pasireotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Pasireotide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Li... |
DB00675 | DB11581 | 888 | 1,456 | [
"DDInter1744",
"DDInter1926"
] | Tamoxifen | Venetoclax | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
888,
25,
1456
]
],
[
[
888,
23,
1135
],
[
1135,
23,
1456
]
],
[
[
888,
63,
536
],
[
536,
24,
1456
]
],
[
[
888,
24,
1476
],
[
1476,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Tamoxifen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital... |
DB01009 | DB08816 | 935 | 578 | [
"DDInter1009",
"DDInter1802"
] | Ketoprofen | Ticagrelor | Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
935,
24,
578
]
],
[
[
935,
21,
28762
],
[
28762,
60,
578
]
],
[
[
935,
1,
1523
],
[
1523,
23,
578
]
],
[
[
935,
63,
1578
],
[
1578,
... | [
[
[
"Ketoprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Ketoprofen",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused... | Ketoprofen (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Ketoprofen (Compound) resembles Labetalol (Compound) and Labetalol may cause a minor interaction that can limit clinical effects when taken with Ticagrelor
Ketoprofen may cause a moderate interaction that c... |
DB00916 | DB06448 | 112 | 171 | [
"DDInter1202",
"DDInter1087"
] | Metronidazole | Lonafarnib | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
112,
24,
171
]
],
[
[
112,
63,
63
],
[
63,
24,
171
]
],
[
[
112,
62,
888
],
[
888,
24,
171
]
],
[
[
112,
24,
310
],
[
310,
63,
... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
],
... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Tamoxifen and Tam... |
DB01229 | DB08868 | 973 | 1,011 | [
"DDInter1377",
"DDInter737"
] | Paclitaxel | Fingolimod | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
973,
25,
1011
]
],
[
[
973,
6,
8374
],
[
8374,
45,
1011
]
],
[
[
973,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
973,
63,
112
],
[
112,
... | [
[
[
"Paclitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Paclitaxel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Fingoli... | Paclitaxel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fingolimod (Compound)
Paclitaxel (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Metronida... |
DB00065 | DB01118 | 581 | 33 | [
"DDInter923",
"DDInter76"
] | Infliximab | Amiodarone | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
581,
24,
33
]
],
[
[
581,
24,
597
],
[
597,
24,
33
]
],
[
[
581,
25,
168
],
[
168,
24,
33
]
],
[
[
581,
25,
1683
],
[
1683,
63,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Amiodarone
Infliximab may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib ... |
DB01278 | DB01319 | 1,021 | 34 | [
"DDInter1506",
"DDInter777"
] | Pramlintide | Fosamprenavir | Pramlintide is a relatively new adjunct treatment for diabetes (both type 1 and 2), developed by Amylin Pharmaceuticals. It is derived from amylin, a hormone that is released into the bloodstream, in a similar pattern as insulin, after a meal. Like insulin, amylin is deficient in individuals with diabetes. | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
1021,
24,
34
]
],
[
[
1021,
63,
1091
],
[
1091,
40,
34
]
],
[
[
1021,
63,
609
],
[
609,
23,
34
]
],
[
[
1021,
63,
1144
],
[
1144,
... | [
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Pramlintide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
... | Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Pramlintide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction ... |
DB00065 | DB15044 | 581 | 631 | [
"DDInter923",
"DDInter1738"
] | Infliximab | Tafasitamab | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Tafasitamab is a humanized, CD19-directed cytolytic monoclonal antibody intended for the treatment of B-cell malignancies. It is produced using recombinant DNA technology in Chinese hamster ovary cells, and contains an IgG1/2 hybrid Fc-domain which has been modified with 2 amino acid substitutions to enhance its cytoto... | Major | 2 | [
[
[
581,
25,
631
]
],
[
[
581,
25,
4
],
[
4,
24,
631
]
],
[
[
581,
64,
1184
],
[
1184,
24,
631
]
],
[
[
581,
24,
597
],
[
597,
24,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tafasitamab"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
],
[
"Omacetaxi... | Infliximab may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Tafasitamab
Infliximab may lead to a major life threatening interaction when taken with Anakinra and Anakinr... |
DB00030 | DB14730 | 1,685 | 1,412 | [
"DDInter934",
"DDInter264"
] | Insulin human | Calaspargase pegol | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
1685,
24,
1412
]
],
[
[
1685,
24,
5
],
[
5,
24,
1412
]
],
[
[
1685,
24,
1101
],
[
1101,
25,
1412
]
],
[
[
1685,
24,
5
],
[
5,
63... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide and Liraglutide may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Bexar... |
DB01320 | DB14723 | 651 | 159 | [
"DDInter783",
"DDInter1026"
] | Fosphenytoin | Larotrectinib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Major | 2 | [
[
[
651,
25,
159
]
],
[
[
651,
25,
466
],
[
466,
23,
159
]
],
[
[
651,
25,
741
],
[
741,
24,
159
]
],
[
[
651,
63,
63
],
[
63,
24,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
]
],
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Darolutamide",
... | Fosphenytoin may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Fosphenytoin may lead to a major life threatening interaction when taken with Rolapitant and Rolapitant may cause a mode... |
DB06603 | DB09046 | 39 | 1,094 | [
"DDInter1387",
"DDInter1201"
] | Panobinostat | Metreleptin | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Metreleptin, a recombinant analog of the human hormone leptin, is an orphan drug used to treat complications of leptin deficiency in people with lipodystrophy. Lipodystrophies include a range of disorders characterized by the reduction, absence, or altered distribution of adipose tissue. Complications of lipodystrophy ... | Moderate | 1 | [
[
[
39,
24,
1094
]
],
[
[
39,
25,
230
],
[
230,
62,
1094
]
],
[
[
39,
25,
180
],
[
180,
63,
1094
]
],
[
[
39,
24,
578
],
[
578,
24,
... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metreleptin"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Relugolix"
],
[
"Relugo... | Panobinostat may lead to a major life threatening interaction when taken with Relugolix and Relugolix may cause a minor interaction that can limit clinical effects when taken with Metreleptin
Panobinostat may lead to a major life threatening interaction when taken with Oliceridine and Oliceridine may cause a moderate i... |
DB01390 | DB09101 | 1,117 | 70 | [
"DDInter1683",
"DDInter633"
] | Sodium bicarbonate | Elvitegravir | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Elvitegravir is a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) used for the treatment of HIV-1 infection in antiretroviral treatment-experienced adults. Because integrase is necessary for viral replication, inhibition prevents the integration of HIV-1 DNA into the host genome ... | Moderate | 1 | [
[
[
1117,
24,
70
]
],
[
[
1117,
24,
1040
],
[
1040,
24,
70
]
],
[
[
1117,
62,
1220
],
[
1220,
24,
70
]
],
[
[
1117,
24,
1040
],
[
1040,
... | [
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elvitegravir"
]
],
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafeni... | Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Elvitegravir
Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Dexam... |
DB06403 | DB09122 | 1,204 | 1,613 | [
"DDInter62",
"DDInter1409"
] | Ambrisentan | Peginterferon beta-1a | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1204,
24,
1613
]
],
[
[
1204,
62,
600
],
[
600,
24,
1613
]
],
[
[
1204,
63,
267
],
[
267,
24,
1613
]
],
[
[
1204,
24,
1320
],
[
1320,
... | [
[
[
"Ambrisentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Ambrisentan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fluconazole"
... | Ambrisentan may cause a minor interaction that can limit clinical effects when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Ambrisentan may cause a moderate interaction that could exacerbate diseases when taken with Naltrexo... |
DB00397 | DB01067 | 1,466 | 959 | [
"DDInter1458",
"DDInter826"
] | Phenylpropanolamine | Glipizide | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1466,
24,
959
]
],
[
[
1466,
63,
245
],
[
245,
40,
959
]
],
[
[
1466,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1466,
21,
28698
],
[
28698,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepirid... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles G... |
DB00358 | DB01015 | 1,010 | 1,247 | [
"DDInter1140",
"DDInter1724"
] | Mefloquine | Sulfamethoxazole | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Minor | 0 | [
[
[
1010,
23,
1247
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
1247
]
],
[
[
1010,
21,
29455
],
[
29455,
60,
1247
]
],
[
[
1010,
25,
11
],
[
11,... | [
[
[
"Mefloquine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sulfamethoxazole (Compound)
Mefloquine (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Sulfamethoxazole (Compound)
Mefloquine may lead to a major life threatening interaction when taken with Toremifene... |
DB00446 | DB12301 | 597 | 907 | [
"DDInter351",
"DDInter585"
] | Chloramphenicol | Doravirine | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
597,
23,
907
]
],
[
[
597,
25,
1478
],
[
1478,
23,
907
]
],
[
[
597,
24,
159
],
[
159,
62,
907
]
],
[
[
597,
24,
1213
],
[
1213,
... | [
[
[
"Chloramphenicol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Chloramphenicol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
],
[
"Iva... | Chloramphenicol may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectini... |
DB00222 | DB00264 | 245 | 88 | [
"DDInter825",
"DDInter1200"
] | Glimepiride | Metoprolol | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Moderate | 1 | [
[
[
245,
24,
88
]
],
[
[
245,
24,
1121
],
[
1121,
1,
88
]
],
[
[
245,
24,
819
],
[
819,
40,
88
]
],
[
[
245,
21,
28897
],
[
28897,
6... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisoprolol"
],
[
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Metoprolol (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Acebutolol and Acebutolol (Compound) resembles Metoprolol (Compound... |
DB00331 | DB00443 | 1,645 | 251 | [
"DDInter1164",
"DDInter195"
] | Metformin | Betamethasone | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Moderate | 1 | [
[
[
1645,
24,
251
]
],
[
[
1645,
24,
870
],
[
870,
1,
251
]
],
[
[
1645,
24,
1486
],
[
1486,
40,
251
]
],
[
[
1645,
62,
1103
],
[
1103,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Betamethasone (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone (Compound) resem... |
DB01238 | DB05812 | 673 | 1,374 | [
"DDInter118",
"DDInter8"
] | Aripiprazole | Abiraterone | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
673,
24,
1374
]
],
[
[
673,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
673,
21,
29113
],
[
29113,
60,
1374
]
],
[
[
673,
62,
112
],
[
112,... | [
[
[
"Aripiprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Aripiprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compou... | Aripiprazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Aripiprazole (Compound) causes Hypokalaemia (Side Effect) and Hypokalaemia (Side Effect) is caused by Abiraterone (Compound)
Aripiprazole may cause a minor interaction that can limit clinical effects when taken with Metroni... |
DB09237 | DB09280 | 1,586 | 1,604 | [
"DDInter1045",
"DDInter1101"
] | Levamlodipine | Lumacaftor | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1586,
25,
1604
]
],
[
[
1586,
63,
1061
],
[
1061,
24,
1604
]
],
[
[
1586,
63,
629
],
[
629,
25,
1604
]
],
[
[
1586,
24,
405
],
[
405,
... | [
[
[
"Levamlodipine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Levamlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
"Tr... | Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Levamlodipine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus a... |
DB01069 | DB11796 | 401 | 1,612 | [
"DDInter1533",
"DDInter786"
] | Promethazine | Fostemsavir | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Fostemsavir is the phosphonooxymethyl prodrug of temsavir, a novel HIV-1 attachment inhibitor. It binds to and inhibits the activity of gp120, a subunit within the HIV-1 gp160 envelope glycoprotein that facilitates the attachment of HIV-1 to host cell CD4 receptors - in doing so, temsavir prevents the first step in the... | Moderate | 1 | [
[
[
401,
24,
1612
]
],
[
[
401,
63,
1324
],
[
1324,
23,
1612
]
],
[
[
401,
62,
112
],
[
112,
23,
1612
]
],
[
[
401,
63,
1424
],
[
1424,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a minor interaction that can limit clinical effects when taken with Fostemsavir
Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole an... |
DB00549 | DB05528 | 522 | 1,070 | [
"DDInter1955",
"DDInter1228"
] | Zafirlukast | Mipomersen | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
522,
25,
1070
]
],
[
[
522,
24,
1250
],
[
1250,
64,
1070
]
],
[
[
522,
24,
14
],
[
14,
25,
1070
]
],
[
[
522,
63,
581
],
[
581,
... | [
[
[
"Zafirlukast",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
],
[
"Pazopanib... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pazopanib may lead to a major life threatening interaction when taken with Mipomersen
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin and Rosuvastatin may le... |
DB00202 | DB01190 | 190 | 568 | [
"DDInter1716",
"DDInter398"
] | Succinylcholine | Clindamycin | Succinylcholine is a depolarizing skeletal muscle relaxant consisting of two molecules of the endogenous neurotransmitter [acetylcholine] (ACh) linked by their acetyl groups. It has been widely used for over 50 years, most commonly in its chloride salt form, as a means of neuromuscular blockade during intubation and su... | Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms[L11599,L11596] as well as topically for acne vulgaris. It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bac... | Moderate | 1 | [
[
[
190,
24,
568
]
],
[
[
190,
21,
28680
],
[
28680,
60,
568
]
],
[
[
190,
25,
1132
],
[
1132,
24,
568
]
],
[
[
190,
21,
28680
],
[
28680,... | [
[
[
"Succinylcholine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clindamycin"
]
],
[
[
"Succinylcholine",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is cau... | Succinylcholine (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Clindamycin (Compound)
Succinylcholine may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Clindamycin
Succinylc... |
DB00572 | DB00726 | 85 | 1,164 | [
"DDInter136",
"DDInter1876"
] | Atropine | Trimipramine | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
85,
24,
1164
]
],
[
[
85,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
85,
63,
508
],
[
508,
40,
1164
]
],
[
[
85,
21,
28809
],
[
28809,
... | [
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Atropine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
],
[
... | Atropine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Atropine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Trimipramine (Compound... |
DB06081 | DB09075 | 1,046 | 498 | [
"DDInter286",
"DDInter621"
] | Caplacizumab | Edoxaban | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
1046,
25,
498
]
],
[
[
1046,
23,
944
],
[
944,
62,
498
]
],
[
[
1046,
24,
41
],
[
41,
24,
498
]
],
[
[
1046,
63,
109
],
[
109,
2... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Caplacizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",... | Caplacizumab may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Edoxaban
Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levom... |
DB00911 | DB01235 | 458 | 1,191 | [
"DDInter1811",
"DDInter1054"
] | Tinidazole | Levodopa | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
458,
24,
1191
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],
[
[
458,
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],
[
28936,
60,
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],
[
[
458,
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63
],
[
63,
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]
],
[
[
458,
24,
148
],
[
148,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Tinidazole",
"{u} (Compound) causes {v} (Side Effect)",
"Hyperhidrosis"
],
[
"Hyperhidrosis",
"{u} (Side Effect) i... | Tinidazole (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Levodopa (Compound)
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with L... |
DB01064 | DB06603 | 1,148 | 39 | [
"DDInter987",
"DDInter1387"
] | Isoprenaline | Panobinostat | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
1148,
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[
[
1148,
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],
[
867,
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],
[
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],
[
144,
63,
39
]
],
[
[
1148,
24,
772
],
[
772,
24... | [
[
[
"Isoprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olanzapine"
],
[
"Olan... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Panobinostat
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and ... |
DB00208 | DB03404 | 1,018 | 765 | [
"DDInter1804",
"DDInter855"
] | Ticlopidine | Hemin | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Moderate | 1 | [
[
[
1018,
24,
765
]
],
[
[
1018,
25,
840
],
[
840,
63,
765
]
],
[
[
1018,
25,
291
],
[
291,
24,
765
]
],
[
[
1018,
64,
1172
],
[
1172,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hemin"
]
],
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vorapaxar"
],
[
"Vorapaxar",
... | Ticlopidine may lead to a major life threatening interaction when taken with Vorapaxar and Vorapaxar may cause a moderate interaction that could exacerbate diseases when taken with Hemin
Ticlopidine may lead to a major life threatening interaction when taken with Argatroban and Argatroban may cause a moderate interacti... |
DB00804 | DB06016 | 1,507 | 1,508 | [
"DDInter543",
"DDInter300"
] | Dicyclomine | Cariprazine | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
1507,
24,
1508
]
],
[
[
1507,
63,
1123
],
[
1123,
24,
1508
]
],
[
[
1507,
24,
272
],
[
272,
24,
1508
]
],
[
[
1507,
24,
849
],
[
849,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
],
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Propantheline and Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Chlorphenira... |
DB05351 | DB14491 | 101 | 428 | [
"DDInter519",
"DDInter725"
] | Dexlansoprazole | Ferrous fumarate | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of, which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generation... | Used in treatment of iron deficiency anemia. | Moderate | 1 | [
[
[
101,
24,
428
]
],
[
[
101,
63,
955
],
[
955,
23,
428
]
],
[
[
101,
24,
320
],
[
320,
24,
428
]
],
[
[
101,
63,
1152
],
[
1152,
2... | [
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous fumarate"
]
],
[
[
"Dexlansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenola... | Dexlansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate
Dexlansoprazole may cause a moderate interaction that could exacerbate diseases w... |
DB00013 | DB14006 | 1,255 | 972 | [
"DDInter1905",
"DDInter370"
] | Urokinase | Choline salicylate | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1255,
24,
972
]
],
[
[
1255,
25,
553
],
[
553,
24,
972
]
],
[
[
1255,
24,
885
],
[
885,
24,
972
]
],
[
[
1255,
64,
1578
],
[
1578,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
],
[
"Fo... | Urokinase may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoproste... |
DB01246 | DB06663 | 820 | 1,154 | [
"DDInter45",
"DDInter1398"
] | Alimemazine | Pasireotide | A phenothiazine derivative that is used as an antipruritic. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
820,
25,
1154
]
],
[
[
820,
21,
28698
],
[
28698,
60,
1154
]
],
[
[
820,
62,
112
],
[
112,
23,
1154
]
],
[
[
820,
24,
1385
],
[
1385,
... | [
[
[
"Alimemazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Alimemazine",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caused by {v} (Com... | Alimemazine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Pasireotide (Compound)
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pasi... |
DB00520 | DB08870 | 1,358 | 850 | [
"DDInter306",
"DDInter228"
] | Caspofungin | Brentuximab vedotin | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
1358,
24,
850
]
],
[
[
1358,
24,
267
],
[
267,
24,
850
]
],
[
[
1358,
63,
305
],
[
305,
24,
850
]
],
[
[
1358,
24,
1017
],
[
1017,
... | [
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Asparagina... |
DB00761 | DB09488 | 1,621 | 103 | [
"DDInter1497",
"DDInter23"
] | Potassium chloride | Acrivastine | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Acrivastine is a triprolidine analog antihistamine indicated for the treatment of allergies and hay fever. As an H1 receptor antagonist, it functions by blocking the action of histamine at this receptor thereby preventing the symptoms associated with histamine release such as pruritis, vasodilation, hypotension, edema,... | Major | 2 | [
[
[
1621,
25,
103
]
],
[
[
1621,
25,
1405
],
[
1405,
24,
103
]
],
[
[
1621,
64,
85
],
[
85,
24,
103
]
],
[
[
1621,
25,
1536
],
[
1536,
... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acrivastine"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cyclobenzaprine"
],
[
"Cyc... | Potassium chloride may lead to a major life threatening interaction when taken with Cyclobenzaprine and Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Acrivastine
Potassium chloride may lead to a major life threatening interaction when taken with Atropine and Atropine ma... |
DB00215 | DB05773 | 1,230 | 1,047 | [
"DDInter388",
"DDInter1848"
] | Citalopram | Trastuzumab emtansine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
1230,
24,
1047
]
],
[
[
1230,
24,
848
],
[
848,
24,
1047
]
],
[
[
1230,
25,
1593
],
[
1593,
63,
1047
]
],
[
[
1230,
62,
168
],
[
168,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Citalopram may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib m... |
DB00443 | DB11714 | 251 | 1,316 | [
"DDInter195",
"DDInter610"
] | Betamethasone | Durvalumab | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Durvalumab is a human immunoglobulin G1 kappa (IgG1κ) monoclonal antibody and a novel immune-checkpoint inhibitor for cancer treatment. Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture, durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote... | Moderate | 1 | [
[
[
251,
24,
1316
]
],
[
[
251,
62,
1461
],
[
1461,
23,
1316
]
],
[
[
251,
23,
1114
],
[
1114,
23,
1316
]
],
[
[
251,
40,
167
],
[
167,
... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Durvalumab"
]
],
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[... | Betamethasone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Durvalumab
Betamethasone may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc s... |
DB00445 | DB01211 | 322 | 609 | [
"DDInter655",
"DDInter393"
] | Epirubicin | Clarithromycin | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
322,
24,
609
]
],
[
[
322,
63,
1570
],
[
1570,
24,
609
]
],
[
[
322,
7,
3466
],
[
3466,
46,
609
]
],
[
[
322,
18,
7248
],
[
7248,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin
Epirubicin (Compound) upregulates CCNA1 (Gene) and CCNA1 (Gene) is upregulated by Clarithromycin (Compou... |
DB06288 | DB08881 | 607 | 868 | [
"DDInter77",
"DDInter1925"
] | Amisulpride | Vemurafenib | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
607,
25,
868
]
],
[
[
607,
21,
28714
],
[
28714,
60,
868
]
],
[
[
607,
62,
112
],
[
112,
23,
868
]
],
[
[
607,
63,
480
],
[
480,
... | [
[
[
"Amisulpride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Amisulpride",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused by {v} (Com... | Amisulpride (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Vemurafenib (Compound)
Amisulpride may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Vemu... |
DB01241 | DB09272 | 1,206 | 412 | [
"DDInter812",
"DDInter632"
] | Gemfibrozil | Eluxadoline | Gemfibrozil is a fibric acid agent, similar to [clofibrate], used to treat Type IIb, IV, and V hyperlipidemias.[A185777,L8525] Gemfibrozil is not a first line treatment and is prescribed to patients who have not responded adequately to weight loss, diet, exercise, and other medications. Gemfibrozil was granted FDA appr... | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Major | 2 | [
[
[
1206,
25,
412
]
],
[
[
1206,
64,
543
],
[
543,
24,
412
]
],
[
[
1206,
63,
663
],
[
663,
24,
412
]
],
[
[
1206,
64,
1101
],
[
1101,
... | [
[
[
"Gemfibrozil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eluxadoline"
]
],
[
[
"Gemfibrozil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Loperamide"
],
[
"Loperamide",
"{u... | Gemfibrozil may lead to a major life threatening interaction when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Gemfibrozil may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may... |
DB00912 | DB01185 | 473 | 155 | [
"DDInter1581",
"DDInter759"
] | Repaglinide | Fluoxymesterone | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. | Moderate | 1 | [
[
[
473,
24,
155
]
],
[
[
473,
24,
1546
],
[
1546,
40,
155
]
],
[
[
473,
63,
1561
],
[
1561,
40,
155
]
],
[
[
473,
63,
175
],
[
175,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluoxymesterone"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Fluoxymesterone (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) resem... |
DB00520 | DB09122 | 1,358 | 1,613 | [
"DDInter306",
"DDInter1409"
] | Caspofungin | Peginterferon beta-1a | Caspofungin (brand name Cancidas worldwide) is an antifungal drug and the first member of a new drug class called the echinocandins, as coined by Merck & Co., Inc. It is typically administered intravenously. It shows activity against infections with Aspergillus and Candida, and works by inhibiting β(1,3)-D-Glucan of th... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1358,
24,
1613
]
],
[
[
1358,
24,
267
],
[
267,
24,
1613
]
],
[
[
1358,
63,
1560
],
[
1560,
24,
1613
]
],
[
[
1358,
24,
1320
],
[
1320... | [
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Caspofungin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
... | Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Caspofungin may cause a moderate interaction that could exacerbate diseases when taken with Pegaspar... |
DB00834 | DB01177 | 932 | 77 | [
"DDInter1215",
"DDInter904"
] | Mifepristone | Idarubicin | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
932,
25,
77
]
],
[
[
932,
6,
12523
],
[
12523,
45,
77
]
],
[
[
932,
7,
5057
],
[
5057,
46,
77
]
],
[
[
932,
18,
10780
],
[
10780,
... | [
[
[
"Mifepristone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Mifepristone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Ida... | Mifepristone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Mifepristone (Compound) upregulates IL1B (Gene) and IL1B (Gene) is upregulated by Idarubicin (Compound)
Mifepristone (Compound) downregulates CCNB2 (Gene) and CCNB2 (Gene) is downregulated by Idarubicin (Compound)
Mifepristo... |
DB00563 | DB00877 | 663 | 629 | [
"DDInter1174",
"DDInter1678"
] | Methotrexate | Sirolimus | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
663,
25,
629
]
],
[
[
663,
6,
4973
],
[
4973,
45,
629
]
],
[
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663,
7,
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],
[
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629
]
],
[
[
663,
18,
10674
],
[
10674,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Siroli... | Methotrexate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sirolimus (Compound)
Methotrexate (Compound) upregulates TRAPPC6A (Gene) and TRAPPC6A (Gene) is upregulated by Sirolimus (Compound)
Methotrexate (Compound) downregulates TMEM50A (Gene) and TMEM50A (Gene) is upregulated by Sirolimus (Compound)
Metho... |
DB00862 | DB09330 | 1,005 | 985 | [
"DDInter1918",
"DDInter1352"
] | Vardenafil | Osimertinib | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
1005,
25,
985
]
],
[
[
1005,
24,
112
],
[
112,
23,
985
]
],
[
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1005,
24,
1478
],
[
1478,
24,
985
]
],
[
[
1005,
24,
657
],
[
657,
... | [
[
[
"Vardenafil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metron... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Iv... |
DB01142 | DB01320 | 1,264 | 651 | [
"DDInter593",
"DDInter783"
] | Doxepin | Fosphenytoin | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Moderate | 1 | [
[
[
1264,
24,
651
]
],
[
[
1264,
63,
307
],
[
307,
1,
651
]
],
[
[
1264,
1,
11305
],
[
11305,
40,
651
]
],
[
[
1264,
6,
6017
],
[
6017,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
"... | Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Fosphenytoin (Compound)
Doxepin (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Fosphenytoin (Compound)
Doxepin (Compound) binds CYP2C9 (Gene) and CYP2C9 ... |
DB00339 | DB09054 | 1,182 | 384 | [
"DDInter1547",
"DDInter905"
] | Pyrazinamide | Idelalisib | A pyrazine that is used therapeutically as an antitubercular agent. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1182,
24,
384
]
],
[
[
1182,
63,
305
],
[
305,
24,
384
]
],
[
[
1182,
24,
322
],
[
322,
24,
384
]
],
[
[
1182,
24,
1613
],
[
1613,
... | [
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Pyrazinamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichi... | Pyrazinamide may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Pyrazinamide may cause a moderate interaction that could exacerbate dise... |
DB01166 | DB09068 | 477 | 1,427 | [
"DDInter379",
"DDInter1948"
] | Cilostazol | Vortioxetine | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
477,
24,
1427
]
],
[
[
477,
63,
25
],
[
25,
24,
1427
]
],
[
[
477,
24,
256
],
[
256,
24,
1427
]
],
[
[
477,
25,
802
],
[
802,
24... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anistreplase"
],
... | Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Anistreplase and Anistreplase may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Prasugrel and P... |
DB00970 | DB04865 | 0 | 4 | [
"DDInter466",
"DDInter1335"
] | Dactinomycin | Omacetaxine mepesuccinate | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Moderate | 1 | [
[
[
0,
24,
4
]
],
[
[
0,
7,
14560
],
[
14560,
46,
4
]
],
[
[
0,
18,
5106
],
[
5106,
46,
4
]
],
[
[
0,
18,
10488
],
[
10488,
57,
... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Dactinomycin",
"{u} (Compound) upregulates {v} (Gene)",
"STAP2"
],
[
"STAP2",
"{u} (Gene) is up... | Dactinomycin (Compound) upregulates STAP2 (Gene) and STAP2 (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dactinomycin (Compound) downregulates ARID4B (Gene) and ARID4B (Gene) is upregulated by Omacetaxine mepesuccinate (Compound)
Dactinomycin (Compound) downregulates B4GAT1 (Gene) and B4GAT1 (Gene) is d... |
DB06403 | DB11827 | 1,204 | 433 | [
"DDInter62",
"DDInter669"
] | Ambrisentan | Ertugliflozin | Ambrisentan is an orally active selective type A endothelin receptor antagonist indicated for the treatment of pulmonary arterial hypertension. It is approved in Europe, Canada and the United States for use as a single agent to improve exercise ability and delay clinical worsening. In addition, it is approved in the Un... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1204,
24,
433
]
],
[
[
1204,
63,
1560
],
[
1560,
24,
433
]
],
[
[
1204,
62,
609
],
[
609,
24,
433
]
],
[
[
1204,
24,
1455
],
[
1455,
... | [
[
[
"Ambrisentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Ambrisentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pegaspargase"
],
... | Ambrisentan may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Ambrisentan may cause a minor interaction that can limit clinical effects when taken with Clarithromycin... |
DB00220 | DB01259 | 798 | 392 | [
"DDInter1276",
"DDInter1024"
] | Nelfinavir | Lapatinib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Major | 2 | [
[
[
798,
25,
392
]
],
[
[
798,
6,
4973
],
[
4973,
45,
392
]
],
[
[
798,
18,
15501
],
[
15501,
57,
392
]
],
[
[
798,
21,
28688
],
[
28688,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lapatinib"... | Nelfinavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lapatinib (Compound)
Nelfinavir (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Lapatinib (Compound)
Nelfinavir (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Nelfi... |
DB06273 | DB11248 | 980 | 1,193 | [
"DDInter1824",
"DDInter1965"
] | Tocilizumab | Zinc gluconate | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
980,
23,
1193
]
],
[
[
980,
64,
1531
],
[
1531,
23,
1193
]
],
[
[
980,
24,
270
],
[
270,
62,
1193
]
],
[
[
980,
63,
66
],
[
66,
... | [
[
[
"Tocilizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Tocilizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Canakinumab"
],
[
"Canak... | Tocilizumab may lead to a major life threatening interaction when taken with Canakinumab and Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab ma... |
DB00285 | DB00816 | 1,100 | 1,674 | [
"DDInter1927",
"DDInter1346"
] | Venlafaxine | Orciprenaline | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
1100,
24,
1674
]
],
[
[
1100,
24,
874
],
[
874,
24,
1674
]
],
[
[
1100,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
1100,
40,
534
],
[
534... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline
Venlafaxine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenali... |
DB06779 | DB09293 | 365 | 116 | [
"DDInter470",
"DDInter954"
] | Dalteparin | Iodide I-131 | Dalteparin, a low molecular weight heparin (LMWH) prepared by nitrous acid degradation of unfractionated heparin of porcine intestinal mucosa origin, is an anticoagulant. It is composed of strongly acidic sulphated polysaccharide chains with an average molecular weight of 5000 and about 90% of the material within the r... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
365,
24,
116
]
],
[
[
365,
24,
1004
],
[
1004,
63,
116
]
],
[
[
365,
25,
498
],
[
498,
24,
116
]
],
[
[
365,
64,
834
],
[
834,
2... | [
[
[
"Dalteparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Dalteparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
],... | Dalteparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate and Phenyl salicylate may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Dalteparin may lead to a major life threatening interaction when taken with Edoxaban and Edoxaba... |
DB12141 | DB12500 | 971 | 283 | [
"DDInter817",
"DDInter714"
] | Gilteritinib | Fedratinib | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
971,
24,
283
]
],
[
[
971,
23,
466
],
[
466,
62,
283
]
],
[
[
971,
64,
351
],
[
351,
23,
283
]
],
[
[
971,
63,
122
],
[
122,
23,... | [
[
[
"Gilteritinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Gilteritinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Darolutamide"
],
... | Gilteritinib may cause a minor interaction that can limit clinical effects when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Gilteritinib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may ca... |
DB00331 | DB01064 | 1,645 | 1,148 | [
"DDInter1164",
"DDInter987"
] | Metformin | Isoprenaline | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1645,
24,
1148
]
],
[
[
1645,
24,
1636
],
[
1636,
24,
1148
]
],
[
[
1645,
21,
28717
],
[
28717,
60,
1148
]
],
[
[
1645,
24,
251
],
[
2... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Metformin (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Isoprenaline (... |
DB06176 | DB08880 | 1,342 | 1,510 | [
"DDInter1616",
"DDInter1771"
] | Romidepsin | Teriflunomide | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1342,
25,
1510
]
],
[
[
1342,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
1342,
24,
129
],
[
129,
63,
1510
]
],
[
[
1342,
24,
1136
],
[
1136... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzal... |
DB00446 | DB00951 | 597 | 1,072 | [
"DDInter351",
"DDInter986"
] | Chloramphenicol | Isoniazid | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
597,
24,
1072
]
],
[
[
597,
6,
8374
],
[
8374,
45,
1072
]
],
[
[
597,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
597,
25,
1135
],
[
1135,... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Chloramphenicol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isoniazid (Compound)
Chloramphenicol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Chloramphenicol may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may... |
DB01254 | DB12240 | 1,213 | 110 | [
"DDInter484",
"DDInter1485"
] | Dasatinib | Polatuzumab vedotin | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
1213,
24,
110
]
],
[
[
1213,
25,
129
],
[
129,
23,
110
]
],
[
[
1213,
63,
467
],
[
467,
24,
110
]
],
[
[
1213,
25,
578
],
[
578,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"E... | Dasatinib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin... |
DB00215 | DB03904 | 1,230 | 1,574 | [
"DDInter388",
"DDInter1903"
] | Citalopram | Urea | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. | Moderate | 1 | [
[
[
1230,
24,
1574
]
],
[
[
1230,
63,
1314
],
[
1314,
24,
1574
]
],
[
[
1230,
24,
657
],
[
657,
63,
1574
]
],
[
[
1230,
25,
497
],
[
497,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Urea"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin may cause a moderate interaction that could exacerbate diseases when taken with Urea
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Castor oil and Castor o... |
DB01175 | DB11186 | 318 | 1,609 | [
"DDInter672",
"DDInter1427"
] | Escitalopram | Pentoxyverine | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
318,
24,
1609
]
],
[
[
318,
63,
104
],
[
104,
24,
1609
]
],
[
[
318,
24,
649
],
[
649,
24,
1609
]
],
[
[
318,
64,
506
],
[
506,
... | [
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Escitalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],... | Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Escitalopram may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol... |
DB00612 | DB00687 | 1,121 | 870 | [
"DDInter216",
"DDInter747"
] | Bisoprolol | Fludrocortisone | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
1121,
24,
870
]
],
[
[
1121,
24,
1220
],
[
1220,
40,
870
]
],
[
[
1121,
63,
251
],
[
251,
40,
870
]
],
[
[
1121,
21,
29317
],
[
29317,... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Fludr... |
DB01015 | DB09268 | 1,247 | 1,662 | [
"DDInter1724",
"DDInter1464"
] | Sulfamethoxazole | Picosulfuric acid | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1247,
24,
1662
]
],
[
[
1247,
23,
484
],
[
484,
63,
1662
]
],
[
[
1247,
24,
1619
],
[
1619,
63,
1662
]
],
[
[
1247,
23,
1618
],
[
1618... | [
[
[
"Sulfamethoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Entrectini... | Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Ru... |
DB03404 | DB09381 | 765 | 192 | [
"DDInter855",
"DDInter678"
] | Hemin | Esterified estrogens | Hemin (trade name Panhematin) is an iron-containing porphyrin. More specifically, it is protoporphyrin IX containing a ferric iron ion (heme B) with a chloride ligand. | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Major | 2 | [
[
[
765,
25,
192
]
],
[
[
765,
24,
283
],
[
283,
63,
192
]
],
[
[
765,
63,
126
],
[
126,
24,
192
]
],
[
[
765,
24,
283
],
[
283,
63,... | [
[
[
"Hemin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Hemin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
"Fedratinib... | Hemin may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Hemin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin... |
DB01232 | DB06228 | 1,327 | 792 | [
"DDInter1640",
"DDInter1609"
] | Saquinavir | Rivaroxaban | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Major | 2 | [
[
[
1327,
25,
792
]
],
[
[
1327,
6,
4973
],
[
4973,
45,
792
]
],
[
[
1327,
21,
28703
],
[
28703,
60,
792
]
],
[
[
1327,
64,
79
],
[
79,
... | [
[
[
"Saquinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Saquinavir",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Rivaroxa... | Saquinavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Rivaroxaban (Compound)
Saquinavir (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Saquinavir may lead to a major life threatening interaction when taken with Sorafenib and Sorafenib may cause a ... |
DB00704 | DB00844 | 267 | 314 | [
"DDInter1263",
"DDInter1257"
] | Naltrexone | Nalbuphine | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Major | 2 | [
[
[
267,
36,
314
]
],
[
[
267,
64,
828
],
[
828,
40,
314
]
],
[
[
267,
40,
173
],
[
173,
63,
314
]
],
[
[
267,
35,
1159
],
[
1159,
4... | [
[
[
"Naltrexone",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Nalbuphine"
]
],
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxycodone"
... | Naltrexone (Compound) resembles Nalbuphine (Compound) and
Naltrexone may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Naltrexone (Compound) resembles Naloxone (Compound) and Naloxone may cause a moderate interaction that could exacerbate... |
DB06228 | DB12825 | 792 | 1,375 | [
"DDInter1609",
"DDInter1032"
] | Rivaroxaban | Lefamulin | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
792,
24,
1375
]
],
[
[
792,
24,
159
],
[
159,
63,
1375
]
],
[
[
792,
63,
1101
],
[
1101,
24,
1375
]
],
[
[
792,
24,
98
],
[
98,
... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and... |
DB00975 | DB01088 | 1,317 | 714 | [
"DDInter573",
"DDInter908"
] | Dipyridamole | Iloprost | A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752) | Iloprost is a mimetic of prostacyclin (PGI2; epoprostenol). Iloprost consists of a mixture of the 4R and 4S diastereoisomers at a ratio of approximately 53:47. It is a potent vasodilator with reported anti-thrombotic properties. | Moderate | 1 | [
[
[
1317,
24,
714
]
],
[
[
1317,
6,
5317
],
[
5317,
45,
714
]
],
[
[
1317,
23,
539
],
[
539,
62,
714
]
],
[
[
1317,
63,
383
],
[
383,
... | [
[
[
"Dipyridamole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloprost"
]
],
[
[
"Dipyridamole",
"{u} (Compound) binds {v} (Gene)",
"PDE4A"
],
[
"PDE4A",
"{u} (Gene) is bound by {v} (Compound)",... | Dipyridamole (Compound) binds PDE4A (Gene) and PDE4A (Gene) is bound by Iloprost (Compound)
Dipyridamole may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Iloprost
Dipyridamole may cause a mod... |
DB00006 | DB00834 | 942 | 932 | [
"DDInter217",
"DDInter1215"
] | Bivalirudin | Mifepristone | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
942,
25,
932
]
],
[
[
942,
24,
848
],
[
848,
63,
932
]
],
[
[
942,
25,
283
],
[
283,
63,
932
]
],
[
[
942,
24,
1061
],
[
1061,
2... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Bivalirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[
"Ibuprof... | Bivalirudin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Mifepristone
Bivalirudin may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may caus... |
DB09052 | DB09268 | 250 | 1,662 | [
"DDInter220",
"DDInter1464"
] | Blinatumomab | Picosulfuric acid | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
250,
24,
1662
]
],
[
[
250,
63,
597
],
[
597,
24,
1662
]
],
[
[
250,
64,
534
],
[
534,
24,
1662
]
],
[
[
250,
24,
180
],
[
180,
... | [
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"... | Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Blinatumomab may lead to a major life threatening interaction when taken with Tramadol and Tr... |
DB00626 | DB04834 | 1,441 | 276 | [
"DDInter161",
"DDInter1571"
] | Bacitracin | Rapacuronium | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Moderate | 1 | [
[
[
1441,
24,
276
]
],
[
[
1441,
63,
91
],
[
91,
24,
276
]
],
[
[
1441,
40,
1481
],
[
1481,
25,
276
]
],
[
[
1441,
25,
1448
],
[
1448,
... | [
[
[
"Bacitracin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rapacuronium"
]
],
[
[
"Bacitracin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
... | Bacitracin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Bacitracin (Compound) resembles Polymyxin B (Compound) and Polymyxin B may lead to a major life threatening in... |
DB09156 | DB14600 | 777 | 224 | [
"DDInter964",
"DDInter620"
] | Iopromide | Edetate disodium anhydrous | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Edetate disodium anhydrous is a polyvalent chelating agent used to treat hypercalcemia and digitalis toxicity associated ventricular arrhythmias. | Major | 2 | [
[
[
777,
25,
224
]
],
[
[
777,
64,
372
],
[
372,
24,
224
]
],
[
[
777,
64,
789
],
[
789,
24,
372
],
[
372,
24,
224
]
],
[
[
777,
64,... | [
[
[
"Iopromide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edetate disodium anhydrous"
]
],
[
[
"Iopromide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clofarabine"
],
[
"Clofarabin... | Iopromide may lead to a major life threatening interaction when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Edetate disodium anhydrous
Iopromide may lead to a major life threatening interaction when taken with Foscarnet and Foscarnet may cause a... |
DB00258 | DB01133 | 666 | 1,104 | [
"DDInter270",
"DDInter1808"
] | Calcium acetate | Tiludronic acid | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Moderate | 1 | [
[
[
666,
24,
1104
]
],
[
[
666,
21,
28809
],
[
28809,
60,
1104
]
],
[
[
666,
21,
28809
],
[
28809,
60,
361
],
[
361,
24,
1104
]
],
[
[
666... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiludronic acid"
]
],
[
[
"Calcium acetate",
"{u} (Compound) causes {v} (Side Effect)",
"Diarrhoea"
],
[
"Diarrhoea",
"{u} (Side ... | Calcium acetate (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Tiludronic acid (Compound)
Calcium acetate (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Neomycin (Compound) and Neomycin may cause a moderate interaction that could exacerbate disease... |
DB11767 | DB14443 | 1,583 | 987 | [
"DDInter1643",
"DDInter1931"
] | Sarilumab | Vibrio cholerae CVD 103-HgR strain live antigen | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1583,
24,
987
]
],
[
[
1583,
63,
305
],
[
305,
24,
987
]
],
[
[
1583,
64,
259
],
[
259,
24,
987
]
],
[
[
1583,
24,
738
],
[
738,
... | [
[
[
"Sarilumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Sarilumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",... | Sarilumab may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Sarilumab may lead to a major life thr... |
DB01015 | DB05294 | 1,247 | 1,069 | [
"DDInter1724",
"DDInter1917"
] | Sulfamethoxazole | Vandetanib | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Minor | 0 | [
[
[
1247,
23,
1069
]
],
[
[
1247,
6,
1829
],
[
1829,
45,
1069
]
],
[
[
1247,
21,
28883
],
[
28883,
60,
1069
]
],
[
[
1247,
62,
112
],
[
11... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vandetanib"
]
],
[
[
"Sulfamethoxazole",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compoun... | Sulfamethoxazole (Compound) binds ALB (Gene) and ALB (Gene) is bound by Vandetanib (Compound)
Sulfamethoxazole (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Vandetanib (Compound)
Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with M... |
DB00816 | DB00934 | 1,674 | 413 | [
"DDInter1346",
"DDInter1124"
] | Orciprenaline | Maprotiline | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
1674,
24,
413
]
],
[
[
1674,
63,
1302
],
[
1302,
40,
413
]
],
[
[
1674,
63,
847
],
[
847,
1,
413
]
],
[
[
1674,
18,
16549
],
[
16549,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
]... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) resembles Maproti... |
DB01233 | DB09128 | 1,311 | 1,241 | [
"DDInter1197",
"DDInter231"
] | Metoclopramide | Brexpiprazole | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Major | 2 | [
[
[
1311,
25,
1241
]
],
[
[
1311,
24,
741
],
[
741,
63,
1241
]
],
[
[
1311,
63,
506
],
[
506,
24,
1241
]
],
[
[
1311,
25,
820
],
[
820,
... | [
[
[
"Metoclopramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
],
[
... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant and Rolapitant may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Dextrometh... |
DB00705 | DB01377 | 441 | 1,283 | [
"DDInter496",
"DDInter1119"
] | Delavirdine | Magnesium oxide | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Moderate | 1 | [
[
[
441,
24,
1283
]
],
[
[
441,
24,
167
],
[
167,
23,
1283
]
],
[
[
441,
63,
1573
],
[
1573,
23,
1283
]
],
[
[
441,
25,
1468
],
[
1468,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Predniso... |
DB06372 | DB11627 | 259 | 1,367 | [
"DDInter1594",
"DDInter860"
] | Rilonacept | Hepatitis B Vaccine (Recombinant) | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
259,
24,
1367
]
],
[
[
259,
63,
1083
],
[
1083,
24,
1367
]
],
[
[
259,
64,
1064
],
[
1064,
24,
1367
]
],
[
[
259,
24,
1480
],
[
1480,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trif... | Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Rilonacept may lead to a major life threatening interaction when taken with Cladribin... |
DB08901 | DB09074 | 1,468 | 1,362 | [
"DDInter1492",
"DDInter1327"
] | Ponatinib | Olaparib | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
1468,
24,
1362
]
],
[
[
1468,
24,
627
],
[
627,
63,
1362
]
],
[
[
1468,
63,
896
],
[
896,
24,
1362
]
],
[
[
1468,
64,
702
],
[
702,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bictegravir"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir and Bictegravir may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide... |
DB00083 | DB00835 | 677 | 100 | [
"DDInter225",
"DDInter245"
] | Botulinum toxin type A | Brompheniramine | In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperf... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
677,
24,
100
]
],
[
[
677,
24,
832
],
[
832,
24,
100
]
],
[
[
677,
24,
1264
],
[
1264,
63,
100
]
],
[
[
677,
24,
662
],
[
662,
3... | [
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Botulinum toxin type A",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Botulinum toxin type A may cause a moderate interaction that could exacerbate diseases ... |
DB04868 | DB08932 | 478 | 1,398 | [
"DDInter1293",
"DDInter1111"
] | Nilotinib | Macitentan | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Moderate | 1 | [
[
[
478,
24,
1398
]
],
[
[
478,
6,
8374
],
[
8374,
45,
1398
]
],
[
[
478,
21,
29429
],
[
29429,
60,
1398
]
],
[
[
478,
24,
283
],
[
283,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Macitentan"
]
],
[
[
"Nilotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Nilotinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Macitentan (Compound)
Nilotinib (Compound) causes Infestation NOS (Side Effect) and Infestation NOS (Side Effect) is caused by Macitentan (Compound)
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib... |
DB00258 | DB00808 | 666 | 1,605 | [
"DDInter270",
"DDInter916"
] | Calcium acetate | Indapamide | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Moderate | 1 | [
[
[
666,
24,
1605
]
],
[
[
666,
24,
811
],
[
811,
1,
1605
]
],
[
[
666,
21,
29282
],
[
29282,
60,
1605
]
],
[
[
666,
24,
1669
],
[
1669,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metolazone"
]... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Calcium acetate (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Indapamide (Compound)
Calcium acetate may cause a mode... |
DB00305 | DB11793 | 377 | 738 | [
"DDInter1232",
"DDInter1297"
] | Mitomycin | Niraparib | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Niraparib is an orally active poly (ADP-ribose) polymerase (PARP) inhibitor. By blocking the enzymes responsible for DNA repair, niraparib induces cytotoxicity in cancer cells. Niraparib is selective towards PARP-1 and PARP-2. First approved by the FDA on March 27, 2017, niraparib is used to treat epithelial ovarian, f... | Moderate | 1 | [
[
[
377,
24,
738
]
],
[
[
377,
24,
1033
],
[
1033,
63,
738
]
],
[
[
377,
24,
663
],
[
663,
24,
738
]
],
[
[
377,
63,
1253
],
[
1253,
... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
]
],
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
],
[
... | Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib
Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrex... |
DB00372 | DB00909 | 999 | 306 | [
"DDInter1793",
"DDInter1971"
] | Thiethylperazine | Zonisamide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Major | 2 | [
[
[
999,
25,
306
]
],
[
[
999,
24,
1609
],
[
1609,
63,
306
]
],
[
[
999,
24,
506
],
[
506,
24,
306
]
],
[
[
999,
25,
1311
],
[
1311,
... | [
[
[
"Thiethylperazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zonisamide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
],
[
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine and Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Zonisamide
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Dex... |
DB01067 | DB09128 | 959 | 1,241 | [
"DDInter826",
"DDInter231"
] | Glipizide | Brexpiprazole | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
959,
24,
1241
]
],
[
[
959,
24,
549
],
[
549,
24,
1241
]
],
[
[
959,
24,
1296
],
[
1296,
63,
1241
]
],
[
[
959,
63,
1179
],
[
1179,
... | [
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Glipizide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Insulin deglud... |
DB00762 | DB00999 | 613 | 504 | [
"DDInter973",
"DDInter883"
] | Irinotecan | Hydrochlorothiazide | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Moderate | 1 | [
[
[
613,
24,
504
]
],
[
[
613,
24,
1326
],
[
1326,
40,
504
]
],
[
[
613,
24,
178
],
[
178,
1,
504
]
],
[
[
613,
63,
323
],
[
323,
40... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide (Compound) resembles Hydrochlorothiazide (Compound)
Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Hyd... |
DB00370 | DB09073 | 1,251 | 951 | [
"DDInter1230",
"DDInter1379"
] | Mirtazapine | Palbociclib | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Moderate | 1 | [
[
[
1251,
24,
951
]
],
[
[
1251,
24,
1476
],
[
1476,
63,
951
]
],
[
[
1251,
63,
600
],
[
600,
24,
951
]
],
[
[
1251,
24,
1040
],
[
1040,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fl... |
DB00705 | DB00959 | 441 | 1,486 | [
"DDInter496",
"DDInter1191"
] | Delavirdine | Methylprednisolone | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
441,
25,
1486
]
],
[
[
441,
64,
175
],
[
175,
40,
1486
]
],
[
[
441,
24,
167
],
[
167,
1,
1486
]
],
[
[
441,
25,
617
],
[
617,
4... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolon... | Delavirdine may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylprednis... |
DB00361 | DB01174 | 134 | 697 | [
"DDInter1939",
"DDInter1442"
] | Vinorelbine | Phenobarbital | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
134,
24,
697
]
],
[
[
134,
24,
759
],
[
759,
1,
697
]
],
[
[
134,
63,
362
],
[
362,
1,
697
]
],
[
[
134,
24,
536
],
[
536,
40,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Phenobarbital (Compou... |
DB00261 | DB00569 | 702 | 553 | [
"DDInter93",
"DDInter775"
] | Anagrelide | Fondaparinux | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Major | 2 | [
[
[
702,
25,
553
]
],
[
[
702,
21,
28789
],
[
28789,
60,
553
]
],
[
[
702,
23,
539
],
[
539,
62,
553
]
],
[
[
702,
24,
1416
],
[
1416,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
]
],
[
[
"Anagrelide",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness",
"{u} (Side Effe... | Anagrelide (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Fondaparinux (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when ... |
DB00637 | DB01254 | 1,557 | 1,213 | [
"DDInter128",
"DDInter484"
] | Astemizole | Dasatinib | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1557,
24,
1213
]
],
[
[
1557,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
1557,
7,
18110
],
[
18110,
46,
1213
]
],
[
[
1557,
18,
10375
],
[
1... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Astemizole",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Astemizole (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Astemizole (Compound) upregulates ST6GALNAC2 (Gene) and ST6GALNAC2 (Gene) is upregulated by Dasatinib (Compound)
Astemizole (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Dasatinib (Compound)
Astemiz... |
DB00363 | DB00668 | 695 | 874 | [
"DDInter419",
"DDInter652"
] | Clozapine | Epinephrine | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Moderate | 1 | [
[
[
695,
24,
874
]
],
[
[
695,
24,
688
],
[
688,
63,
874
]
],
[
[
695,
25,
1674
],
[
1674,
63,
874
]
],
[
[
695,
6,
7950
],
[
7950,
... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine
Clozapine may lead to a major life threatening interaction when taken with Orciprenaline and Orciprenaline may c... |
DB00570 | DB01611 | 147 | 1,487 | [
"DDInter1936",
"DDInter893"
] | Vinblastine | Hydroxychloroquine | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
147,
24,
1487
]
],
[
[
147,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
147,
7,
9853
],
[
9853,
57,
1487
]
],
[
[
147,
21,
28658
],
[
28658... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (C... | Vinblastine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Vinblastine (Compound) upregulates TES (Gene) and TES (Gene) is downregulated by Hydroxychloroquine (Compound)
Vinblastine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloro... |
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