drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00352 | DB08864 | 482 | 786 | [
"DDInter1814",
"DDInter1595"
] | Tioguanine | Rilpivirine | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
482,
24,
786
]
],
[
[
482,
21,
28722
],
[
28722,
60,
786
]
],
[
[
482,
24,
522
],
[
522,
24,
786
]
],
[
[
482,
63,
1560
],
[
1560,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by... | Tioguanine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Rilpivirine (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Zafirlukast and Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirin... |
DB00889 | DB01209 | 1,133 | 1,359 | [
"DDInter840",
"DDInter531"
] | Granisetron | Dezocine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
1133,
24,
1359
]
],
[
[
1133,
64,
234
],
[
234,
1,
1359
]
],
[
[
1133,
40,
85
],
[
85,
24,
1359
]
],
[
[
1133,
1,
19
],
[
19,
24... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pentazocine"
],
[
"Pentazoci... | Granisetron may lead to a major life threatening interaction when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Granisetron (Compound) resembles Atropine (Compound) and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Dezocine
Granisetron (Compou... |
DB01044 | DB06723 | 246 | 115 | [
"DDInter809",
"DDInter58"
] | Gatifloxacin | Aluminum hydroxide | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
246,
24,
115
]
],
[
[
246,
21,
28643
],
[
28643,
60,
115
]
],
[
[
246,
64,
870
],
[
870,
23,
115
]
],
[
[
246,
63,
355
],
[
355,
... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) causes {v} (Side Effect)",
"Infection"
],
[
"Infection",
"{u} (Side Eff... | Gatifloxacin (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Aluminum hydroxide (Compound)
Gatifloxacin may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Al... |
DB00404 | DB00835 | 523 | 100 | [
"DDInter54",
"DDInter245"
] | Alprazolam | Brompheniramine | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
523,
24,
100
]
],
[
[
523,
24,
832
],
[
832,
24,
100
]
],
[
[
523,
24,
649
],
[
649,
63,
100
]
],
[
[
523,
63,
1594
],
[
1594,
2... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Clofedan... |
DB01319 | DB06626 | 34 | 263 | [
"DDInter777",
"DDInter147"
] | Fosamprenavir | Axitinib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Major | 2 | [
[
[
34,
25,
263
]
],
[
[
34,
63,
1215
],
[
1215,
23,
263
]
],
[
[
34,
24,
101
],
[
101,
23,
263
]
],
[
[
34,
64,
392
],
[
392,
24,
... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axitinib"
]
],
[
[
"Fosamprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
[
"Lans... | Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a minor interaction that can limit clinical effects when taken with Axitinib
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Dexlansoprazole... |
DB00352 | DB00641 | 482 | 467 | [
"DDInter1814",
"DDInter1675"
] | Tioguanine | Simvastatin | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
482,
24,
467
]
],
[
[
482,
6,
7129
],
[
7129,
57,
467
]
],
[
[
482,
21,
28722
],
[
28722,
60,
467
]
],
[
[
482,
24,
800
],
[
800,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Tioguanine",
"{u} (Compound) binds {v} (Gene)",
"HPRT1"
],
[
"HPRT1",
"{u} (Gene) is downregulated by {v} (Comp... | Tioguanine (Compound) binds HPRT1 (Gene) and HPRT1 (Gene) is downregulated by Simvastatin (Compound)
Tioguanine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Simvastatin (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib and Duv... |
DB00290 | DB01042 | 329 | 1,307 | [
"DDInter219",
"DDInter1144"
] | Bleomycin | Melphalan | A complex of related glycopeptide antibiotics from <i>Streptomyces verticillus</i> consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin. | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Moderate | 1 | [
[
[
329,
24,
1307
]
],
[
[
329,
5,
11555
],
[
11555,
44,
1307
]
],
[
[
329,
21,
28766
],
[
28766,
60,
1307
]
],
[
[
329,
23,
956
],
[
956,... | [
[
[
"Bleomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Melphalan"
]
],
[
[
"Bleomycin",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) ... | Bleomycin (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Melphalan (Compound)
Bleomycin (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Melphalan (Compound)
Bleomycin may cause a minor interaction that can limit clinical effects when ... |
DB00377 | DB00582 | 1,494 | 1,622 | [
"DDInter1382",
"DDInter1946"
] | Palonosetron | Voriconazole | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
1494,
24,
1622
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
1494,
21,
28957
],
[
28957,
60,
1622
]
],
[
[
1494,
23,
112
],
[
11... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Palonosetron (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Voriconazole (Compound)
Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronida... |
DB00835 | DB11642 | 100 | 938 | [
"DDInter245",
"DDInter1480"
] | Brompheniramine | Pitolisant | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
100,
24,
938
]
],
[
[
100,
1,
28
],
[
28,
24,
938
]
],
[
[
100,
63,
1233
],
[
1233,
24,
938
]
],
[
[
100,
24,
820
],
[
820,
24,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Brompheniramine",
"{u} (Compound) resembles {v} (Compound)",
"Bisacodyl"
],
[
"Bisacodyl",
"{u} may cause a... | Brompheniramine (Compound) resembles Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Triprolidine and Triprolidine may cause a moderate interactio... |
DB00694 | DB00850 | 51 | 1,630 | [
"DDInter485",
"DDInter1432"
] | Daunorubicin | Perphenazine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
51,
24,
1630
]
],
[
[
51,
63,
252
],
[
252,
40,
1630
]
],
[
[
51,
24,
673
],
[
673,
40,
1630
]
],
[
[
51,
64,
684
],
[
684,
40,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Perphenazi... |
DB00582 | DB00959 | 1,622 | 1,486 | [
"DDInter1946",
"DDInter1191"
] | Voriconazole | Methylprednisolone | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Major | 2 | [
[
[
1622,
25,
1486
]
],
[
[
1622,
25,
175
],
[
175,
40,
1486
]
],
[
[
1622,
24,
167
],
[
167,
1,
1486
]
],
[
[
1622,
63,
251
],
[
251,
... | [
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Voriconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinol... | Voriconazole may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Methylpredn... |
DB00486 | DB00754 | 1,614 | 157 | [
"DDInter1253",
"DDInter696"
] | Nabilone | Ethotoin | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
1614,
24,
157
]
],
[
[
1614,
24,
759
],
[
759,
40,
157
]
],
[
[
1614,
24,
499
],
[
499,
1,
157
]
],
[
[
1614,
21,
28763
],
[
28763,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
[
"Pr... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Phensuximide and Phensuximide (Compound) resembles Ethotoin (Compound)
Nabilo... |
DB00762 | DB00834 | 613 | 932 | [
"DDInter973",
"DDInter1215"
] | Irinotecan | Mifepristone | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
613,
25,
932
]
],
[
[
613,
6,
7524
],
[
7524,
45,
932
]
],
[
[
613,
7,
6314
],
[
6314,
46,
932
]
],
[
[
613,
18,
10699
],
[
10699,
... | [
[
[
"Irinotecan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Irinotecan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Mifep... | Irinotecan (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Mifepristone (Compound)
Irinotecan (Compound) upregulates TLR4 (Gene) and TLR4 (Gene) is upregulated by Mifepristone (Compound)
Irinotecan (Compound) downregulates KIF20A (Gene) and KIF20A (Gene) is downregulated by Mifepristone (Compound)
Irinotec... |
DB01175 | DB12141 | 318 | 971 | [
"DDInter672",
"DDInter817"
] | Escitalopram | Gilteritinib | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Major | 2 | [
[
[
318,
25,
971
]
],
[
[
318,
62,
112
],
[
112,
23,
971
]
],
[
[
318,
64,
485
],
[
485,
24,
971
]
],
[
[
318,
25,
823
],
[
823,
63,... | [
[
[
"Escitalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gilteritinib"
]
],
[
[
"Escitalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Escitalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Escitalopram may lead to a major life threatening interaction when taken with Pentamidine and Pentamidine ... |
DB00197 | DB09061 | 1,324 | 1,627 | [
"DDInter1881",
"DDInter284"
] | Troglitazone | Cannabidiol | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1324,
24,
1627
]
],
[
[
1324,
24,
723
],
[
723,
23,
1627
]
],
[
[
1324,
24,
351
],
[
351,
62,
1627
]
],
[
[
1324,
24,
888
],
[
888,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Rib... |
DB01075 | DB08883 | 1,376 | 1,597 | [
"DDInter569",
"DDInter1428"
] | Diphenhydramine | Perampanel | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
1376,
24,
1597
]
],
[
[
1376,
74,
100
],
[
100,
24,
1597
]
],
[
[
1376,
24,
649
],
[
649,
24,
1597
]
],
[
[
1376,
63,
104
],
[
104,
... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases wh... | Diphenhydramine (Compound) resembles Brompheniramine (Compound) and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Perampanel
Diphenhydramine may cause a m... |
DB00434 | DB00782 | 13 | 1,123 | [
"DDInter459",
"DDInter1535"
] | Cyproheptadine | Propantheline | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Moderate | 1 | [
[
[
13,
24,
1123
]
],
[
[
13,
6,
7992
],
[
7992,
45,
1123
]
],
[
[
13,
21,
28898
],
[
28898,
60,
1123
]
],
[
[
13,
24,
551
],
[
551,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propantheline"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Co... | Cyproheptadine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Propantheline (Compound)
Cyproheptadine (Compound) causes Constipation (Side Effect) and Constipation (Side Effect) is caused by Propantheline (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00374 | DB08907 | 1,061 | 1,344 | [
"DDInter1852",
"DDInter280"
] | Treprostinil | Canagliflozin | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1061,
24,
1344
]
],
[
[
1061,
24,
549
],
[
549,
1,
1344
]
],
[
[
1061,
21,
28680
],
[
28680,
60,
1344
]
],
[
[
1061,
24,
1445
],
[
144... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Treprostinil (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Canagliflozin (Compound)
Treprostinil may cause a moderate inte... |
DB01070 | DB14012 | 1,098 | 349 | [
"DDInter558",
"DDInter253"
] | Dihydrotachysterol | Burosumab | A vitamin D that can be regarded as a reduction product of vitamin D2. | Burosumab (KRN23) is an entirely human monoclonal IgG1 antibody that binds excess fibroblast growth factor 23 (FGF23) and has been successfully tested in clinical trials in children with X-linked hypophosphatemic rickets . The U.S. Food and Drug Administration approved Crysvita (burosumab) in April 2018. This is the fi... | Major | 2 | [
[
[
1098,
25,
349
]
],
[
[
1098,
25,
1196
],
[
1196,
25,
349
]
],
[
[
1098,
64,
1041
],
[
1041,
25,
349
]
],
[
[
1098,
25,
1196
],
[
1196,... | [
[
[
"Dihydrotachysterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Burosumab"
]
],
[
[
"Dihydrotachysterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxercalciferol"
],
[
"Doxer... | Dihydrotachysterol may lead to a major life threatening interaction when taken with Doxercalciferol and Doxercalciferol may lead to a major life threatening interaction when taken with Burosumab
Dihydrotachysterol may lead to a major life threatening interaction when taken with Paricalcitol and Paricalcitol may lead to... |
DB00738 | DB06335 | 485 | 761 | [
"DDInter1420",
"DDInter1646"
] | Pentamidine | Saxagliptin | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
485,
24,
761
]
],
[
[
485,
6,
7524
],
[
7524,
45,
761
]
],
[
[
485,
21,
29226
],
[
29226,
60,
761
]
],
[
[
485,
24,
1491
],
[
1491,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Pentamidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound... | Pentamidine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Saxagliptin (Compound)
Pentamidine (Compound) causes Sinusitis (Side Effect) and Sinusitis (Side Effect) is caused by Saxagliptin (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin an... |
DB00916 | DB01098 | 112 | 14 | [
"DDInter1202",
"DDInter1622"
] | Metronidazole | Rosuvastatin | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
112,
24,
14
]
],
[
[
112,
24,
671
],
[
671,
24,
14
]
],
[
[
112,
6,
8374
],
[
8374,
45,
14
]
],
[
[
112,
21,
29462
],
[
29462,
6... | [
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Metronidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],... | Metronidazole may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Metronidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rosuvastatin (Compound)
Metron... |
DB01001 | DB06288 | 688 | 607 | [
"DDInter1632",
"DDInter77"
] | Salbutamol | Amisulpride | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Moderate | 1 | [
[
[
688,
24,
607
]
],
[
[
688,
21,
29232
],
[
29232,
60,
607
]
],
[
[
688,
62,
112
],
[
112,
23,
607
]
],
[
[
688,
63,
1559
],
[
1559,
... | [
[
[
"Salbutamol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amisulpride"
]
],
[
[
"Salbutamol",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is cau... | Salbutamol (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Amisulpride (Compound)
Salbutamol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Amis... |
DB00078 | DB04865 | 1,172 | 4 | [
"DDInter898",
"DDInter1335"
] | Ibritumomab tiuxetan | Omacetaxine mepesuccinate | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Major | 2 | [
[
[
1172,
25,
4
]
],
[
[
1172,
24,
496
],
[
496,
63,
4
]
],
[
[
1172,
24,
66
],
[
66,
24,
4
]
],
[
[
1172,
63,
1253
],
[
1253,
24,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatit... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate
Ibritumomab tiuxetan may cause a moderate interaction that could exac... |
DB01601 | DB12245 | 833 | 823 | [
"DDInter1089",
"DDInter1863"
] | Lopinavir | Triclabendazole | Lopinavir is an antiretroviral protease inhibitor used in combination with other antiretrovirals in the treatment of HIV-1 infection. Lopinavir is marketed and administered exclusively in combination with [ritonavir] - this combination, first marketed by Abbott under the brand name Kaletra in 2000, is necessary due to ... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
833,
24,
823
]
],
[
[
833,
63,
1010
],
[
1010,
24,
823
]
],
[
[
833,
24,
28
],
[
28,
24,
823
]
],
[
[
833,
25,
868
],
[
868,
25,... | [
[
[
"Lopinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Lopinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
],
[... | Lopinavir may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole
Lopinavir may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bisa... |
DB00586 | DB01175 | 1,512 | 318 | [
"DDInter537",
"DDInter672"
] | Diclofenac | Escitalopram | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
1512,
24,
318
]
],
[
[
1512,
63,
1230
],
[
1230,
1,
318
]
],
[
[
1512,
6,
8374
],
[
8374,
45,
318
]
],
[
[
1512,
21,
29461
],
[
29461,... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Diclofenac (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Diclofenac (Compound) causes Dysmenorrhoea (Side Effect) and D... |
DB11828 | DB12141 | 1,406 | 971 | [
"DDInter1281",
"DDInter817"
] | Neratinib | Gilteritinib | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1406,
24,
971
]
],
[
[
1406,
62,
1135
],
[
1135,
23,
971
]
],
[
[
1406,
63,
72
],
[
72,
24,
971
]
],
[
[
1406,
25,
1339
],
[
1339,
... | [
[
[
"Neratinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Neratinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Neratinib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Neratinib may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltrombopag... |
DB08932 | DB09054 | 1,398 | 384 | [
"DDInter1111",
"DDInter905"
] | Macitentan | Idelalisib | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Major | 2 | [
[
[
1398,
25,
384
]
],
[
[
1398,
63,
305
],
[
305,
24,
384
]
],
[
[
1398,
24,
1619
],
[
1619,
63,
384
]
],
[
[
1398,
25,
760
],
[
760,
... | [
[
[
"Macitentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
]
],
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli"
],
... | Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Macitentan may cause a moderate interaction that could exacerbate diseases... |
DB00620 | DB11952 | 175 | 800 | [
"DDInter1855",
"DDInter612"
] | Triamcinolone | Duvelisib | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. All the work around duvelisib showed tha... | Moderate | 1 | [
[
[
175,
24,
800
]
],
[
[
175,
63,
663
],
[
663,
24,
800
]
],
[
[
175,
24,
270
],
[
270,
63,
800
]
],
[
[
175,
24,
1683
],
[
1683,
2... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Duvelisib"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
],
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Duvelisib
Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab ... |
DB01126 | DB06589 | 1,260 | 1,250 | [
"DDInter611",
"DDInter1400"
] | Dutasteride | Pazopanib | Dutasteride is an oral synthetic 4-azasteroid commonly marketed under the trade name Avodart. It is a novel dual 5α-reductase inhibitor that works by blocking both isoforms of 5α-reductase enzymes in a potent, selective, and irreversible manner. Type I and II 5α-reductase enzymes convert testosterone into dihydrotestos... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1260,
24,
1250
]
],
[
[
1260,
6,
8374
],
[
8374,
45,
1250
]
],
[
[
1260,
21,
28680
],
[
28680,
60,
1250
]
],
[
[
1260,
63,
1419
],
[
1... | [
[
[
"Dutasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Dutasteride",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Dutasteride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Pazopanib (Compound)
Dutasteride (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Pazopanib (Compound)
Dutasteride may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may ca... |
DB00477 | DB01344 | 216 | 1,231 | [
"DDInter363",
"DDInter1830"
] | Chlorpromazine | Tolevamer | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
216,
24,
1231
]
],
[
[
216,
62,
417
],
[
417,
24,
1231
]
],
[
[
216,
40,
1178
],
[
1178,
24,
1231
]
],
[
[
216,
24,
870
],
[
870,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Chlorpromazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sucralfate"
],
... | Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Chlorpromazine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine may cause a moderate interac... |
DB00211 | DB06706 | 1,290 | 468 | [
"DDInter1213",
"DDInter985"
] | Midodrine | Isometheptene | An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. | Isometheptene is a sympathomimetic drug that causes vasoconstriction. It is used for treating migraines and tension headaches. | Moderate | 1 | [
[
[
1290,
24,
468
]
],
[
[
1290,
6,
5214
],
[
5214,
45,
468
]
],
[
[
1290,
24,
480
],
[
480,
24,
468
]
],
[
[
1290,
24,
144
],
[
144,
... | [
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isometheptene"
]
],
[
[
"Midodrine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound)"... | Midodrine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Isometheptene (Compound)
Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isometheptene
Midodrine may ... |
DB00054 | DB14276 | 1,432 | 1,631 | [
"DDInter6",
"DDInter1892"
] | Abciximab | Turmeric | Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αv... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
1432,
23,
1631
]
],
[
[
1432,
64,
20
],
[
20,
23,
1631
]
],
[
[
1432,
25,
1018
],
[
1018,
23,
1631
]
],
[
[
1432,
24,
1479
],
[
1479,
... | [
[
[
"Abciximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Turmeric"
]
],
[
[
"Abciximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
"Tenecteplase",... | Abciximab may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Turmeric
Abciximab may lead to a major life threatening interaction when taken with Ticlopidine and Ticlopidine may cause a minor interac... |
DB00220 | DB11921 | 798 | 1,019 | [
"DDInter1276",
"DDInter492"
] | Nelfinavir | Deflazacort | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Major | 2 | [
[
[
798,
25,
1019
]
],
[
[
798,
24,
959
],
[
959,
24,
1019
]
],
[
[
798,
24,
1619
],
[
1619,
63,
1019
]
],
[
[
798,
25,
629
],
[
629,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deflazacort"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
"Glipizide"... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapari... |
DB00524 | DB01261 | 811 | 170 | [
"DDInter1199",
"DDInter1679"
] | Metolazone | Sitagliptin | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
811,
24,
170
]
],
[
[
811,
18,
1866
],
[
1866,
57,
170
]
],
[
[
811,
21,
28850
],
[
28850,
60,
170
]
],
[
[
811,
24,
52
],
[
52,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Metolazone",
"{u} (Compound) downregulates {v} (Gene)",
"SLC38A1"
],
[
"SLC38A1",
"{u} (Gene) is downregulated ... | Metolazone (Compound) downregulates SLC38A1 (Gene) and SLC38A1 (Gene) is downregulated by Sitagliptin (Compound)
Metolazone (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Metolazone may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00880 | DB11921 | 359 | 1,019 | [
"DDInter360",
"DDInter492"
] | Chlorothiazide | Deflazacort | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
359,
24,
1019
]
],
[
[
359,
24,
959
],
[
959,
24,
1019
]
],
[
[
359,
40,
1326
],
[
1326,
24,
1019
]
],
[
[
359,
63,
355
],
[
355,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Chlorothiazide may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Chlorothiazide (Compound) resembles Diclofenamide (Compound) and Diclofenamide may cause a moderate interacti... |
DB00845 | DB06616 | 1,490 | 594 | [
"DDInter406",
"DDInter224"
] | Clofazimine | Bosutinib | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1490,
24,
594
]
],
[
[
1490,
6,
8374
],
[
8374,
45,
594
]
],
[
[
1490,
21,
28709
],
[
28709,
60,
594
]
],
[
[
1490,
23,
112
],
[
112,
... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Clofazimine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Clofazimine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Clofazimine (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Bosutinib (Compound)
Clofazimine may cause a minor interaction that can limit clinical effects when taken with Me... |
DB00427 | DB00985 | 1,233 | 1,443 | [
"DDInter1879",
"DDInter562"
] | Triprolidine | Dimenhydrinate | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery. Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyl... | Moderate | 1 | [
[
[
1233,
24,
1443
]
],
[
[
1233,
1,
11268
],
[
11268,
1,
1443
]
],
[
[
1233,
24,
1376
],
[
1376,
63,
1443
]
],
[
[
1233,
63,
357
],
[
357... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimenhydrinate"
]
],
[
[
"Triprolidine",
"{u} (Compound) resembles {v} (Compound)",
"Cloperastine"
],
[
"Cloperastine",
"{u} (Compou... | Triprolidine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compound) resembles Dimenhydrinate (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when ... |
DB00334 | DB09268 | 867 | 1,662 | [
"DDInter1326",
"DDInter1464"
] | Olanzapine | Picosulfuric acid | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
867,
24,
1662
]
],
[
[
867,
24,
484
],
[
484,
63,
1662
]
],
[
[
867,
24,
1618
],
[
1618,
24,
1662
]
],
[
[
867,
1,
87
],
[
87,
2... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
],
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib and Entrectinib may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib... |
DB09075 | DB11095 | 498 | 235 | [
"DDInter621",
"DDInter505"
] | Edoxaban | Desirudin | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
498,
25,
235
]
],
[
[
498,
23,
297
],
[
297,
23,
235
]
],
[
[
498,
63,
1100
],
[
1100,
24,
235
]
],
[
[
498,
24,
1004
],
[
1004,
... | [
[
[
"Edoxaban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Edoxaban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u} may... | Edoxaban may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Edoxaban may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may cause a ... |
DB00398 | DB12010 | 79 | 214 | [
"DDInter1702",
"DDInter785"
] | Sorafenib | Fostamatinib | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
79,
24,
214
]
],
[
[
79,
24,
690
],
[
690,
24,
214
]
],
[
[
79,
24,
861
],
[
861,
63,
214
]
],
[
[
79,
25,
924
],
[
924,
24,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib and Ripretin... |
DB00668 | DB01309 | 874 | 1,254 | [
"DDInter652",
"DDInter933"
] | Epinephrine | Insulin glulisine | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
874,
24,
1254
]
],
[
[
874,
63,
1645
],
[
1645,
24,
1254
]
],
[
[
874,
25,
887
],
[
887,
24,
1254
]
],
[
[
874,
24,
480
],
[
480,
... | [
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Epinephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metformin"
],
... | Epinephrine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Epinephrine may lead to a major life threatening interaction when taken with Pindolol and Pindolol may cau... |
DB06372 | DB11988 | 259 | 270 | [
"DDInter1594",
"DDInter1321"
] | Rilonacept | Ocrelizumab | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
259,
24,
270
]
],
[
[
259,
23,
1193
],
[
1193,
23,
270
]
],
[
[
259,
62,
1461
],
[
1461,
23,
270
]
],
[
[
259,
24,
1060
],
[
1060,
... | [
[
[
"Rilonacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Rilonacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[... | Rilonacept may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Rilonacept may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB00275 | DB09038 | 217 | 1,450 | [
"DDInter1330",
"DDInter636"
] | Olmesartan | Empagliflozin | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
217,
24,
1450
]
],
[
[
217,
24,
1061
],
[
1061,
24,
1450
]
],
[
[
217,
1,
911
],
[
911,
24,
1450
]
],
[
[
217,
63,
1179
],
[
1179,
... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Olmesartan (Compound) resembles Azilsartan medoxomil (Compound) and Azilsartan medoxomil may cause a mode... |
DB08868 | DB15091 | 1,011 | 676 | [
"DDInter737",
"DDInter1901"
] | Fingolimod | Upadacitinib | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1011,
25,
676
]
],
[
[
1011,
63,
1430
],
[
1430,
24,
676
]
],
[
[
1011,
24,
748
],
[
748,
24,
676
]
],
[
[
1011,
64,
1593
],
[
1593,
... | [
[
[
"Fingolimod",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Fingolimod",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine... |
DB01246 | DB08871 | 820 | 36 | [
"DDInter45",
"DDInter666"
] | Alimemazine | Eribulin | A phenothiazine derivative that is used as an antipruritic. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
820,
24,
36
]
],
[
[
820,
63,
122
],
[
122,
23,
36
]
],
[
[
820,
62,
1247
],
[
1247,
23,
36
]
],
[
[
820,
24,
519
],
[
519,
24,
... | [
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Alimemazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
],
[
... | Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Alimemazine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfam... |
DB00888 | DB11601 | 1,001 | 1,270 | [
"DDInter1133",
"DDInter1889"
] | Mechlorethamine | Tuberculin purified protein derivative | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1001,
24,
1270
]
],
[
[
1001,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
1001,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
1001,
63,
1555
],
[
15... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Mechlorethamine may lead to a major life threatening interaction when taken w... |
DB00514 | DB01501 | 506 | 1,118 | [
"DDInter527",
"DDInter549"
] | Dextromethorphan | Difenoxin | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Difenoxin is a 4-phenylpiperidine which is closely related to the opioid analgesic meperidine. Difenoxin alone is a USA Schedule I controlled drug, as it may be habit forming. However, it is listed as a Schedule IV controlled drug if combined with atropine, which is added to decrease deliberate misuse. Motofen(R) is a ... | Moderate | 1 | [
[
[
506,
24,
1118
]
],
[
[
506,
63,
576
],
[
576,
1,
1118
]
],
[
[
506,
24,
1688
],
[
1688,
40,
1118
]
],
[
[
506,
63,
194
],
[
194,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Difenoxin"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methadone"
]... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone (Compound) resembles Difenoxin (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Diphenoxylate and Diphenoxylate (Compound) resembles Difenox... |
DB01192 | DB04837 | 560 | 649 | [
"DDInter1372",
"DDInter407"
] | Oxymorphone | Clofedanol | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
560,
24,
649
]
],
[
[
560,
63,
1376
],
[
1376,
24,
649
]
],
[
[
560,
63,
832
],
[
832,
40,
649
]
],
[
[
560,
24,
1511
],
[
1511,
... | [
[
[
"Oxymorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Oxymorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
... | Oxymorphone may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Oxymorphone may cause a moderate interaction that could exacerbate diseases when taken with Tripelenn... |
DB11095 | DB15233 | 235 | 1,650 | [
"DDInter505",
"DDInter142"
] | Desirudin | Avapritinib | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Major | 2 | [
[
[
235,
25,
1650
]
],
[
[
235,
63,
557
],
[
557,
24,
1650
]
],
[
[
235,
24,
738
],
[
738,
24,
1650
]
],
[
[
235,
64,
1512
],
[
1512,
... | [
[
[
"Desirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Avapritinib"
]
],
[
[
"Desirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
],
[
"Deoxy... | Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid and Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib ... |
DB00009 | DB01381 | 1,271 | 958 | [
"DDInter56",
"DDInter819"
] | Alteplase | Ginkgo biloba | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
1271,
24,
958
]
],
[
[
1271,
24,
1347
],
[
1347,
24,
958
]
],
[
[
1271,
25,
126
],
[
126,
24,
958
]
],
[
[
1271,
25,
792
],
[
792,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clopidogrel"
],
[
... | Alteplase may cause a moderate interaction that could exacerbate diseases when taken with Clopidogrel and Clopidogrel may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Alteplase may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a... |
DB01177 | DB11642 | 77 | 938 | [
"DDInter904",
"DDInter1480"
] | Idarubicin | Pitolisant | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
77,
24,
938
]
],
[
[
77,
62,
112
],
[
112,
23,
938
]
],
[
[
77,
63,
600
],
[
600,
24,
938
]
],
[
[
77,
24,
1228
],
[
1228,
24,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Idarubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Idarubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Flu... |
DB01205 | DB01589 | 1,404 | 481 | [
"DDInter748",
"DDInter1552"
] | Flumazenil | Quazepam | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Moderate | 1 | [
[
[
1404,
24,
481
]
],
[
[
1404,
63,
1216
],
[
1216,
1,
481
]
],
[
[
1404,
24,
1418
],
[
1418,
1,
481
]
],
[
[
1404,
63,
905
],
[
905,
... | [
[
[
"Flumazenil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quazepam"
]
],
[
[
"Flumazenil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
],
[
... | Flumazenil may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Quazepam (Compound)
Flumazenil may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Quazepam (Compound)
Flumaz... |
DB00443 | DB00580 | 251 | 311 | [
"DDInter195",
"DDInter1910"
] | Betamethasone | Valdecoxib | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
251,
24,
311
]
],
[
[
251,
24,
473
],
[
473,
63,
311
]
],
[
[
251,
24,
663
],
[
663,
24,
311
]
],
[
[
251,
63,
1560
],
[
1560,
2... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate ... |
DB00215 | DB00358 | 1,230 | 1,010 | [
"DDInter388",
"DDInter1140"
] | Citalopram | Mefloquine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Major | 2 | [
[
[
1230,
25,
1010
]
],
[
[
1230,
6,
8374
],
[
8374,
45,
1010
]
],
[
[
1230,
18,
7623
],
[
7623,
57,
1010
]
],
[
[
1230,
21,
29362
],
[
29... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mefloquine"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Mefloqu... | Citalopram (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound)
Citalopram (Compound) downregulates RRP12 (Gene) and RRP12 (Gene) is downregulated by Mefloquine (Compound)
Citalopram (Compound) causes Leukocytosis (Side Effect) and Leukocytosis (Side Effect) is caused by Mefloquine (Compou... |
DB00601 | DB01156 | 453 | 593 | [
"DDInter1073",
"DDInter252"
] | Linezolid | Bupropion | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Major | 2 | [
[
[
453,
25,
593
]
],
[
[
453,
21,
28757
],
[
28757,
60,
593
]
],
[
[
453,
63,
1214
],
[
1214,
24,
593
]
],
[
[
453,
24,
126
],
[
126,
... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
]
],
[
[
"Linezolid",
"{u} (Compound) causes {v} (Side Effect)",
"Dyspepsia"
],
[
"Dyspepsia",
"{u} (Side Effect) is caused by {v} (Compoun... | Linezolid (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (Side Effect) is caused by Bupropion (Compound)
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Minoxidil and Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Bupropion
Li... |
DB00366 | DB00690 | 1,594 | 1,216 | [
"DDInter600",
"DDInter762"
] | Doxylamine | Flurazepam | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | A benzodiazepine derivative used mainly as a hypnotic. | Moderate | 1 | [
[
[
1594,
24,
1216
]
],
[
[
1594,
24,
1418
],
[
1418,
1,
1216
]
],
[
[
1594,
24,
481
],
[
481,
40,
1216
]
],
[
[
1594,
63,
902
],
[
902,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
],
[
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Flurazepam (Compound)
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Quazepam and Quazepam (Compound) resembles Flurazepam (Compound)
Doxyla... |
DB00705 | DB01611 | 441 | 1,487 | [
"DDInter496",
"DDInter893"
] | Delavirdine | Hydroxychloroquine | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
441,
24,
1487
]
],
[
[
441,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
441,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
441,
63,
723
],
[
723,... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Delavirdine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (C... | Delavirdine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Delavirdine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Ap... |
DB00880 | DB11348 | 359 | 1,065 | [
"DDInter360",
"DDInter279"
] | Chlorothiazide | Calcium Phosphate | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Calcium phosphate is typically available as an over the counter supplement, antacid, or as an added ingredient in some toothpastes [FDA Label] . | Moderate | 1 | [
[
[
359,
24,
1065
]
],
[
[
359,
40,
1014
],
[
1014,
24,
1065
]
],
[
[
359,
62,
1620
],
[
1620,
24,
1065
]
],
[
[
359,
23,
1669
],
[
1669,
... | [
[
[
"Chlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium Phosphate"
]
],
[
[
"Chlorothiazide",
"{u} (Compound) resembles {v} (Compound)",
"Benzthiazide"
],
[
"Benzthiazide",
"{u} ... | Chlorothiazide (Compound) resembles Benzthiazide (Compound) and Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Calcium Phosphate
Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Tetracycline and Tetracycline may cause a moderate i... |
DB00046 | DB11255 | 1,179 | 1,371 | [
"DDInter940",
"DDInter374"
] | Insulin lispro | Chromium picolinate | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are show... | Moderate | 1 | [
[
[
1179,
24,
1371
]
],
[
[
1179,
24,
245
],
[
245,
24,
1371
]
],
[
[
1179,
24,
1385
],
[
1385,
63,
1371
]
],
[
[
1179,
24,
245
],
[
245,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromium picolinate"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepirid... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Chromium picolinate
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Se... |
DB06210 | DB09330 | 72 | 985 | [
"DDInter631",
"DDInter1352"
] | Eltrombopag | Osimertinib | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
72,
24,
985
]
],
[
[
72,
24,
119
],
[
119,
63,
985
]
],
[
[
72,
63,
663
],
[
663,
24,
985
]
],
[
[
72,
24,
286
],
[
286,
24,
... | [
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Eltrombopag",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
],
... | Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib and Talazoparib may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and... |
DB06273 | DB09121 | 980 | 1,328 | [
"DDInter1824",
"DDInter140"
] | Tocilizumab | Aurothioglucose | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Aurothioglucose, also known as gold thioglucose, was formerly used to treat rheumatoid arthritis. Contemporary research on the effect of gold salts treatment began in 1935, primarily to reduce inflammation and to slow disease progression in patients with rheumatoid arthritis . The use of gold compounds has decreased si... | Moderate | 1 | [
[
[
980,
24,
1328
]
],
[
[
980,
63,
367
],
[
367,
24,
1328
]
],
[
[
980,
64,
581
],
[
581,
24,
1328
]
],
[
[
980,
24,
310
],
[
310,
... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aurothioglucose"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Interferon alfacon-1... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfacon-1 and Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Aurothioglucose
Tocilizumab may lead to a major life threatening interaction when taken with Inflixima... |
DB00852 | DB01367 | 1,445 | 1,163 | [
"DDInter1545",
"DDInter1572"
] | Pseudoephedrine | Rasagiline | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
1445,
24,
1163
]
],
[
[
1445,
21,
28714
],
[
28714,
60,
1163
]
],
[
[
1445,
63,
590
],
[
590,
24,
1163
]
],
[
[
1445,
74,
1466
],
[
14... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Pseudoephedrine",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect)... | Pseudoephedrine (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Rasagiline (Compound)
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and Acetohexamide may cause a moderate interaction that could exacerbate diseases when take... |
DB00741 | DB09020 | 167 | 28 | [
"DDInter885",
"DDInter212"
] | Hydrocortisone | Bisacodyl | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
167,
24,
28
]
],
[
[
167,
18,
20113
],
[
20113,
46,
28
]
],
[
[
167,
7,
3361
],
[
3361,
46,
28
]
],
[
[
167,
6,
1899
],
[
1899,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Hydrocortisone",
"{u} (Compound) downregulates {v} (Gene)",
"IER3"
],
[
"IER3",
"{u} (Gene) is upregulated by... | Hydrocortisone (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Bisacodyl (Compound)
Hydrocortisone (Compound) upregulates NFIL3 (Gene) and NFIL3 (Gene) is upregulated by Bisacodyl (Compound)
Hydrocortisone (Compound) binds NR3C1 (Gene) and NR3C1 (Gene) is upregulated by Bisacodyl (Compound)
Hydro... |
DB00656 | DB06699 | 827 | 774 | [
"DDInter1851",
"DDInter493"
] | Trazodone | Degarelix | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
827,
24,
774
]
],
[
[
827,
63,
521
],
[
521,
1,
774
]
],
[
[
827,
21,
29232
],
[
29232,
60,
774
]
],
[
[
827,
23,
112
],
[
112,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Trazodone (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Trazodone may cause a minor interaction that can l... |
DB00390 | DB05351 | 1,252 | 101 | [
"DDInter554",
"DDInter519"
] | Digoxin | Dexlansoprazole | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Dexlansoprazole is a new-generation proton pump inhibitor (PPI) used for the management of symptoms associated with gastroesophageal reflux disease (GERD) and erosive esophagitis. Dexlansoprazole is the R-enantiomer of , which is composed of a racemic mixture of the R- and S-enantiomers. Compared to the older generatio... | Moderate | 1 | [
[
[
1252,
24,
101
]
],
[
[
1252,
24,
1479
],
[
1479,
23,
101
]
],
[
[
1252,
24,
1468
],
[
1468,
62,
101
]
],
[
[
1252,
23,
361
],
[
361,
... | [
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexlansoprazole"
]
],
[
[
"Digoxin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],... | Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole
Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Pona... |
DB09039 | DB11652 | 1,670 | 1,155 | [
"DDInter629",
"DDInter1891"
] | Eliglustat | Tucatinib | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Tucatinib is a kinase inhibitor drug used with [trastuzumab] and [capecitabine] in the treatment of unresectable or metastatic HER-2 positive breast cancer. It was developed by Seattle Genetics and approved by the FDA on April 17, 2020. Tucatinib is a promising new treatment for patients with metastatic breast cancer w... | Major | 2 | [
[
[
1670,
25,
1155
]
],
[
[
1670,
63,
1101
],
[
1101,
23,
1155
]
],
[
[
1670,
64,
609
],
[
609,
24,
1155
]
],
[
[
1670,
63,
522
],
[
522,
... | [
[
[
"Eliglustat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tucatinib"
]
],
[
[
"Eliglustat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene"... | Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Tucatinib
Eliglustat may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may c... |
DB01211 | DB01607 | 609 | 1,390 | [
"DDInter393",
"DDInter1803"
] | Clarithromycin | Ticarcillin | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | An antibiotic derived from penicillin similar to carbenicillin in action. | Minor | 0 | [
[
[
609,
23,
1390
]
],
[
[
609,
62,
514
],
[
514,
40,
1390
]
],
[
[
609,
23,
339
],
[
339,
1,
1390
]
],
[
[
609,
62,
950
],
[
950,
1... | [
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ticarcillin"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Benzylpenicillin"
... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Benzylpenicillin and Benzylpenicillin (Compound) resembles Ticarcillin (Compound)
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Bacampicillin and Bacampicillin (Compound) resembles... |
DB00586 | DB01110 | 1,512 | 86 | [
"DDInter537",
"DDInter1209"
] | Diclofenac | Miconazole | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Moderate | 1 | [
[
[
1512,
24,
86
]
],
[
[
1512,
6,
6365
],
[
6365,
45,
86
]
],
[
[
1512,
21,
29122
],
[
29122,
60,
86
]
],
[
[
1512,
24,
318
],
[
318,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Miconazole"
]
],
[
[
"Diclofenac",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)",... | Diclofenac (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Miconazole (Compound)
Diclofenac (Compound) causes Mediastinal disorder (Side Effect) and Mediastinal disorder (Side Effect) is caused by Miconazole (Compound)
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00526 | DB10316 | 1,555 | 334 | [
"DDInter1355",
"DDInter1248"
] | Oxaliplatin | Mumps virus strain B level jeryl lynn live antigen | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1555,
25,
334
]
],
[
[
1555,
24,
594
],
[
594,
25,
334
]
],
[
[
1555,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1555,
25,
908
],
[
908,
... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib and Bosutinib may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Oxaliplatin may lead to a major life threatening interaction when taken with Etanercept ... |
DB00726 | DB06694 | 1,164 | 31 | [
"DDInter1876",
"DDInter1952"
] | Trimipramine | Xylometazoline (nasal) | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Xylometazoline is an alkylbenzene. | Moderate | 1 | [
[
[
1164,
24,
31
]
],
[
[
1164,
6,
5214
],
[
5214,
45,
31
]
],
[
[
1164,
24,
144
],
[
144,
63,
31
]
],
[
[
1164,
24,
1148
],
[
1148,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Xylometazoline"
]
],
[
[
"Trimipramine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Com... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Xylometazoline
Trimipramine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Xylometazoline (Compound)
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olod... |
DB00687 | DB08868 | 870 | 1,011 | [
"DDInter747",
"DDInter737"
] | Fludrocortisone | Fingolimod | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
870,
25,
1011
]
],
[
[
870,
21,
28714
],
[
28714,
60,
1011
]
],
[
[
870,
24,
61
],
[
61,
24,
1011
]
],
[
[
870,
63,
751
],
[
751,
... | [
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Asthenia"
],
[
"Asthenia",
"{u} (Side Effect) is caused by {... | Fludrocortisone (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Fingolimod (Compound)
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB01105 | DB09098 | 222 | 98 | [
"DDInter1665",
"DDInter1700"
] | Sibutramine | Somatrem | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
222,
24,
98
]
],
[
[
222,
24,
1671
],
[
1671,
24,
98
]
],
[
[
222,
23,
159
],
[
159,
63,
98
]
],
[
[
222,
23,
609
],
[
609,
24,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Somatrem
Sibutramine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib and Lar... |
DB01115 | DB06691 | 336 | 849 | [
"DDInter1291",
"DDInter1155"
] | Nifedipine | Mepyramine | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
336,
24,
849
]
],
[
[
336,
6,
12523
],
[
12523,
45,
849
]
],
[
[
336,
63,
770
],
[
770,
24,
849
]
],
[
[
336,
40,
1428
],
[
1428,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Nifedipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Nifedipine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Mepyramine (Compound)
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Nifedipine (Comp... |
DB00327 | DB00889 | 421 | 1,133 | [
"DDInter890",
"DDInter840"
] | Hydromorphone | Granisetron | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
421,
24,
1133
]
],
[
[
421,
24,
19
],
[
19,
40,
1133
]
],
[
[
421,
24,
85
],
[
85,
1,
1133
]
],
[
[
421,
6,
8374
],
[
8374,
45,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Comp... |
DB00584 | DB01261 | 610 | 170 | [
"DDInter638",
"DDInter1679"
] | Enalapril | Sitagliptin | Enalapril is a prodrug belonging to the angiotensin-converting enzyme (ACE) inhibitor drug class that works on the renin-angiotensin-aldosterone system, which is responsible for the regulation of blood pressure and fluid and electrolyte homeostasis. Enalapril is an orally-active and long-acting nonsulphydryl antihypert... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
610,
24,
170
]
],
[
[
610,
6,
8374
],
[
8374,
45,
170
]
],
[
[
610,
18,
3671
],
[
3671,
57,
170
]
],
[
[
610,
21,
28850
],
[
28850,
... | [
[
[
"Enalapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Enalapril",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Enalapril (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sitagliptin (Compound)
Enalapril (Compound) downregulates CD40 (Gene) and CD40 (Gene) is downregulated by Sitagliptin (Compound)
Enalapril (Compound) causes Back pain (Side Effect) and Back pain (Side Effect) is caused by Sitagliptin (Compound)
Enal... |
DB08912 | DB09083 | 1,040 | 880 | [
"DDInter462",
"DDInter996"
] | Dabrafenib | Ivabradine | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Moderate | 1 | [
[
[
1040,
24,
880
]
],
[
[
1040,
63,
1478
],
[
1478,
24,
880
]
],
[
[
1040,
24,
159
],
[
159,
63,
880
]
],
[
[
1040,
24,
951
],
[
951,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivabradine"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB01097 | DB13915 | 1,377 | 689 | [
"DDInter1033",
"DDInter146"
] | Leflunomide | Axicabtagene ciloleucel | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. The drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. Once T-cells are collected from the patient, they are genetically engineered to express ant... | Major | 2 | [
[
[
1377,
25,
689
]
],
[
[
1377,
64,
599
],
[
599,
24,
689
]
],
[
[
1377,
25,
270
],
[
270,
24,
689
]
],
[
[
1377,
24,
1430
],
[
1430,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Axicabtagene ciloleucel"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alemtuzumab"
],
[
"Alemtuzum... | Leflunomide may lead to a major life threatening interaction when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Axicabtagene ciloleucel
Leflunomide may lead to a major life threatening interaction when taken with Ocrelizumab and Ocrelizumab may ca... |
DB08860 | DB08865 | 788 | 1,593 | [
"DDInter1479",
"DDInter448"
] | Pitavastatin | Crizotinib | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
788,
24,
1593
]
],
[
[
788,
18,
1748
],
[
1748,
45,
1593
]
],
[
[
788,
6,
4973
],
[
4973,
45,
1593
]
],
[
[
788,
7,
7580
],
[
7580,
... | [
[
[
"Pitavastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Pitavastatin",
"{u} (Compound) downregulates {v} (Gene)",
"IGF1R"
],
[
"IGF1R",
"{u} (Gene) is bound by {v} (C... | Pitavastatin (Compound) downregulates IGF1R (Gene) and IGF1R (Gene) is bound by Crizotinib (Compound)
Pitavastatin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Crizotinib (Compound)
Pitavastatin (Compound) upregulates TESK1 (Gene) and TESK1 (Gene) is bound by Crizotinib (Compound)
Pitavastatin (Compound) ... |
DB09312 | DB00163 | 967 | 1,461 | [
"DDInter106",
"DDInter1943"
] | Antithymocyte immunoglobulin (rabbit) | Vitamin E | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin i... | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Minor | 0 | [
[
[
967,
23,
1461
]
],
[
[
967,
64,
581
],
[
581,
23,
1461
]
],
[
[
967,
25,
1510
],
[
1510,
62,
1461
]
],
[
[
967,
63,
66
],
[
66,
... | [
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
]
],
[
[
"Antilymphocyte immunoglobulin (horse)",
"{u} may lead to a major life threatening interaction when taken with {v}"... | Antilymphocyte immunoglobulin (horse) may cause a minor interaction that can limit clinical effects when taken with Vitamin E
Antilymphocyte immunoglobulin (horse) may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a minor interaction that can limit clinical effects whe... |
DB08904 | DB11627 | 375 | 1,367 | [
"DDInter342",
"DDInter860"
] | Certolizumab pegol | Hepatitis B Vaccine (Recombinant) | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Moderate | 1 | [
[
[
375,
24,
1367
]
],
[
[
375,
64,
1083
],
[
1083,
24,
1367
]
],
[
[
375,
25,
1480
],
[
1480,
24,
1367
]
],
[
[
375,
25,
119
],
[
119,
... | [
[
[
"Certolizumab pegol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis B Vaccine (Recombinant)"
]
],
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tri... | Certolizumab pegol may lead to a major life threatening interaction when taken with Trifluridine and Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis B Vaccine (Recombinant)
Certolizumab pegol may lead to a major life threatening interaction when taken with Ixazomib... |
DB00398 | DB11853 | 79 | 230 | [
"DDInter1702",
"DDInter1577"
] | Sorafenib | Relugolix | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
79,
24,
230
]
],
[
[
79,
24,
129
],
[
129,
23,
230
]
],
[
[
79,
23,
112
],
[
112,
23,
230
]
],
[
[
79,
63,
1101
],
[
1101,
23,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Sorafenib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metron... |
DB00687 | DB01390 | 870 | 1,117 | [
"DDInter747",
"DDInter1683"
] | Fludrocortisone | Sodium bicarbonate | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Minor | 0 | [
[
[
870,
23,
1117
]
],
[
[
870,
21,
28778
],
[
28778,
60,
1117
]
],
[
[
870,
1,
1220
],
[
1220,
23,
1117
]
],
[
[
870,
62,
1018
],
[
1018,... | [
[
[
"Fludrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sodium bicarbonate"
]
],
[
[
"Fludrocortisone",
"{u} (Compound) causes {v} (Side Effect)",
"Anaphylactic shock"
],
[
"Anaphylactic shock"... | Fludrocortisone (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Sodium bicarbonate (Compound)
Fludrocortisone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Sodium bicarbon... |
DB00333 | DB09020 | 576 | 28 | [
"DDInter1166",
"DDInter212"
] | Methadone | Bisacodyl | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
576,
24,
28
]
],
[
[
576,
24,
662
],
[
662,
1,
28
]
],
[
[
576,
24,
128
],
[
128,
40,
28
]
],
[
[
576,
21,
28809
],
[
28809,
60,... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine (Compound) resembles Bisacodyl (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine (Compound) resembles Bis... |
DB09498 | DB15719 | 810 | 487 | [
"DDInter1715",
"DDInter171"
] | Strontium chloride Sr-89 | Belantamab mafodotin | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Belantamab mafodotin, or GSK2857916, is an afucosylated monoclonal antibody that targets B cell maturation antigen conjugated to the microtubule disrupter monomethyl auristatin-F (MMAF). Belantamab mafodotin was granted FDA accelerated approval on 5 August 2020 for the treatment of multiple myeloma; however, its manufa... | Moderate | 1 | [
[
[
810,
24,
487
]
],
[
[
810,
63,
4
],
[
4,
24,
487
]
],
[
[
810,
24,
738
],
[
738,
24,
487
]
],
[
[
810,
63,
976
],
[
976,
25,
... | [
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belantamab mafodotin"
]
],
[
[
"Strontium chloride Sr-89",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v... | Strontium chloride Sr-89 may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Belantamab mafodotin
Strontium chloride Sr-89 may cause a moderate interaction ... |
DB01115 | DB01132 | 336 | 1,130 | [
"DDInter1291",
"DDInter1472"
] | Nifedipine | Pioglitazone | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Minor | 0 | [
[
[
336,
23,
1130
]
],
[
[
336,
6,
12523
],
[
12523,
45,
1130
]
],
[
[
336,
7,
1870
],
[
1870,
46,
1130
]
],
[
[
336,
21,
28778
],
[
28778... | [
[
[
"Nifedipine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pioglitazone"
]
],
[
[
"Nifedipine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",... | Nifedipine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pioglitazone (Compound)
Nifedipine (Compound) upregulates MYC (Gene) and MYC (Gene) is upregulated by Pioglitazone (Compound)
Nifedipine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazo... |
DB00197 | DB09118 | 1,324 | 1,580 | [
"DDInter1881",
"DDInter1711"
] | Troglitazone | Stiripentol | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
1324,
24,
1580
]
],
[
[
1324,
24,
466
],
[
466,
62,
1580
]
],
[
[
1324,
24,
1409
],
[
1409,
24,
1580
]
],
[
[
1324,
24,
283
],
[
283,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Stiripentol
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and A... |
DB00405 | DB00418 | 128 | 536 | [
"DDInter517",
"DDInter1650"
] | Dexbrompheniramine | Secobarbital | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Moderate | 1 | [
[
[
128,
24,
536
]
],
[
[
128,
63,
1023
],
[
1023,
1,
536
]
],
[
[
128,
24,
697
],
[
697,
1,
536
]
],
[
[
128,
24,
682
],
[
682,
40,... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarb... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Secobarbital (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) re... |
DB00425 | DB14568 | 558 | 982 | [
"DDInter1970",
"DDInter1000"
] | Zolpidem | Ivosidenib | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
558,
24,
982
]
],
[
[
558,
63,
1101
],
[
1101,
23,
982
]
],
[
[
558,
24,
770
],
[
770,
24,
982
]
],
[
[
558,
24,
159
],
[
159,
6... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide... |
DB09054 | DB09073 | 384 | 951 | [
"DDInter905",
"DDInter1379"
] | Idelalisib | Palbociclib | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
384,
25,
951
]
],
[
[
384,
23,
907
],
[
907,
62,
951
]
],
[
[
384,
62,
318
],
[
318,
23,
951
]
],
[
[
384,
24,
496
],
[
496,
63,... | [
[
[
"Idelalisib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Idelalisib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[
"Doravirine"... | Idelalisib may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Palbociclib
Idelalisib may cause a minor interaction that can limit clinical effects when taken with Escitalopram and Escitalop... |
DB00938 | DB01254 | 455 | 1,213 | [
"DDInter1635",
"DDInter484"
] | Salmeterol | Dasatinib | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
455,
24,
1213
]
],
[
[
455,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
455,
7,
1986
],
[
1986,
46,
1213
]
],
[
[
455,
18,
2284
],
[
2284,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Salmeterol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Salmeterol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Salmeterol (Compound) upregulates INSIG1 (Gene) and INSIG1 (Gene) is upregulated by Dasatinib (Compound)
Salmeterol (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is downregulated by Dasatinib (Compound)
Salmeterol (Com... |
DB02546 | DB06203 | 137 | 1,002 | [
"DDInter1947",
"DDInter51"
] | Vorinostat | Alogliptin | Vorinostat (rINN) or suberoylanilide hydroxamic acid (SAHA), is a drug currently under investigation for the treatment of cutaneous T cell lymphoma (CTCL), a type of skin cancer, to be used when the disease persists, gets worse, or comes back during or after treatment with other medicines. It is the first in a new clas... | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Moderate | 1 | [
[
[
137,
24,
1002
]
],
[
[
137,
24,
1281
],
[
1281,
40,
1002
]
],
[
[
137,
21,
28966
],
[
28966,
60,
1002
]
],
[
[
137,
63,
176
],
[
176,
... | [
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
]
],
[
[
"Vorinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
],
[
... | Vorinostat may cause a moderate interaction that could exacerbate diseases when taken with Linagliptin and Linagliptin (Compound) resembles Alogliptin (Compound)
Vorinostat (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Alogliptin (Comp... |
DB00559 | DB11828 | 152 | 1,406 | [
"DDInter223",
"DDInter1281"
] | Bosentan | Neratinib | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Major | 2 | [
[
[
152,
25,
1406
]
],
[
[
152,
24,
1135
],
[
1135,
23,
1406
]
],
[
[
152,
24,
392
],
[
392,
24,
1406
]
],
[
[
152,
25,
1510
],
[
1510,
... | [
[
[
"Bosentan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neratinib"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Neratinib
Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may ca... |
DB04953 | DB12245 | 495 | 823 | [
"DDInter708",
"DDInter1863"
] | Ezogabine | Triclabendazole | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
495,
24,
823
]
],
[
[
495,
62,
112
],
[
112,
23,
823
]
],
[
[
495,
63,
1010
],
[
1010,
24,
823
]
],
[
[
495,
24,
28
],
[
28,
24,... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Ezogabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Ezogabine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and M... |
DB00026 | DB01068 | 1,184 | 1,565 | [
"DDInter94",
"DDInter411"
] | Anakinra | Clonazepam | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Moderate | 1 | [
[
[
1184,
24,
1565
]
],
[
[
1184,
24,
1382
],
[
1382,
1,
1565
]
],
[
[
1184,
24,
1031
],
[
1031,
23,
1565
]
],
[
[
1184,
24,
259
],
[
259,... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonazepam"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
],
[
"... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Clonazepam (Compound)
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a minor interaction that can limit ... |
DB00620 | DB00867 | 175 | 1,052 | [
"DDInter1855",
"DDInter1606"
] | Triamcinolone | Ritodrine | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Adrenergic beta-agonist used to control premature labor. | Minor | 0 | [
[
[
175,
23,
1052
]
],
[
[
175,
63,
1523
],
[
1523,
40,
1052
]
],
[
[
175,
40,
1351
],
[
1351,
23,
1052
]
],
[
[
175,
40,
1220
],
[
1220,
... | [
[
[
"Triamcinolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ritodrine"
]
],
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Labetalol"
],
[
... | Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Ritodrine (Compound)
Triamcinolone (Compound) resembles Flunisolide (Compound) and Flunisolide may cause a minor interaction that can limit clinical effects when taken with Ritodrin... |
DB00330 | DB00773 | 238 | 896 | [
"DDInter689",
"DDInter702"
] | Ethambutol | Etoposide | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Moderate | 1 | [
[
[
238,
24,
896
]
],
[
[
238,
21,
28681
],
[
28681,
60,
896
]
],
[
[
238,
24,
147
],
[
147,
23,
896
]
],
[
[
238,
24,
310
],
[
310,
... | [
[
[
"Ethambutol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
]
],
[
[
"Ethambutol",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Ef... | Ethambutol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Etoposide (Compound)
Ethambutol may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine and Vinblastine may cause a minor interaction that can limit clinical effects when taken... |
DB01250 | DB01265 | 712 | 1,477 | [
"DDInter1334",
"DDInter1757"
] | Olsalazine | Telbivudine | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
712,
24,
1477
]
],
[
[
712,
63,
485
],
[
485,
24,
1477
]
],
[
[
712,
64,
629
],
[
629,
24,
1477
]
],
[
[
712,
1,
50
],
[
50,
24,... | [
[
[
"Olsalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Olsalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
],
[
... | Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Telbivudine
Olsalazine may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause... |
DB00227 | DB09098 | 1,463 | 98 | [
"DDInter1098",
"DDInter1700"
] | Lovastatin | Somatrem | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1463,
24,
98
]
],
[
[
1463,
63,
168
],
[
168,
23,
98
]
],
[
[
1463,
24,
159
],
[
159,
63,
98
]
],
[
[
1463,
25,
609
],
[
609,
24... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotre... |
DB00011 | DB01235 | 1,451 | 1,191 | [
"DDInter944",
"DDInter1054"
] | Interferon alfa-n1 | Levodopa | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
1451,
24,
1191
]
],
[
[
1451,
24,
63
],
[
63,
24,
1191
]
],
[
[
1451,
24,
148
],
[
148,
63,
1191
]
],
[
[
1451,
25,
1377
],
[
1377,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Teniposide"
... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Teniposide and Teniposide may cause a moderate interaction that could exacerbate diseases when taken with Levodopa
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Secnida... |
DB01229 | DB08913 | 973 | 1,186 | [
"DDInter1378",
"DDInter1561"
] | Paclitaxel (protein-bound) | Radium Ra 223 dichloride | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
973,
24,
1186
]
],
[
[
973,
21,
28872
],
[
28872,
60,
1186
]
],
[
[
973,
63,
134
],
[
134,
24,
1186
]
],
[
[
973,
24,
1491
],
[
1491,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Paclitaxel",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{u}... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Radium Ra 223 dichloride
Paclitaxel (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Paclitaxel may cause a moderate interaction that could exacerbate ... |
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