drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00604 | DB00808 | 1,425 | 1,605 | [
"DDInter385",
"DDInter916"
] | Cisapride | Indapamide | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | The most significant modifiable risk factor for cardiovascular disease and the most prominent contributor to all-cause mortality is hypertension. Characterized by an office blood pressure of ≥140/90, hypertension is pervasive and impacts an estimated 25% of adults globally. Treatment for hypertension should include a n... | Major | 2 | [
[
[
1425,
25,
1605
]
],
[
[
1425,
64,
811
],
[
811,
1,
1605
]
],
[
[
1425,
24,
1335
],
[
1335,
40,
1605
]
],
[
[
1425,
6,
8374
],
[
8374,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Indapamide"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metolazone"
],
[
"Metolazone",
"{u} (Co... | Cisapride may lead to a major life threatening interaction when taken with Metolazone and Metolazone (Compound) resembles Indapamide (Compound)
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Indapamide (Compound)
Cisapride (... |
DB00467 | DB01073 | 1,467 | 1,488 | [
"DDInter644",
"DDInter745"
] | Enoxacin | Fludarabine | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Minor | 0 | [
[
[
1467,
23,
1488
]
],
[
[
1467,
23,
372
],
[
372,
1,
1488
]
],
[
[
1467,
1,
1539
],
[
1539,
62,
1488
]
],
[
[
1467,
1,
956
],
[
956,
... | [
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludarabine"
]
],
[
[
"Enoxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clofarabine"
],
[
"C... | Enoxacin may cause a minor interaction that can limit clinical effects when taken with Clofarabine and Clofarabine (Compound) resembles Fludarabine (Compound)
Enoxacin (Compound) resembles Ofloxacin (Compound) and Ofloxacin may cause a minor interaction that can limit clinical effects when taken with Fludarabine
Enoxac... |
DB05294 | DB05316 | 1,069 | 749 | [
"DDInter1917",
"DDInter1467"
] | Vandetanib | Pimavanserin | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Pimavanserin is an atypical antipsychotic indicated for the treatment of psychiatric disorders. Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors. Unlike other atypical antipsychotic... | Major | 2 | [
[
[
1069,
25,
749
]
],
[
[
1069,
62,
112
],
[
112,
23,
749
]
],
[
[
1069,
64,
1264
],
[
1264,
24,
749
]
],
[
[
1069,
36,
594
],
[
594,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimavanserin"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pimavanserin
Vandetanib may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a ... |
DB00434 | DB00754 | 13 | 157 | [
"DDInter459",
"DDInter696"
] | Cyproheptadine | Ethotoin | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression. The mechanism of action is probably very similar to that of phenytoin. The latter drug appears to stabilize rather than to raise the normal seizure threshold, and to ... | Moderate | 1 | [
[
[
13,
24,
157
]
],
[
[
13,
24,
759
],
[
759,
40,
157
]
],
[
[
13,
40,
11305
],
[
11305,
40,
157
]
],
[
[
13,
24,
499
],
[
499,
1,
... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethotoin"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Ethotoin (Compound)
Cyproheptadine (Compound) resembles Phenindione (Compound) and Phenindione (Compound) resembles Ethotoin (Compound)
Cyproheptadine may cause a moderate interact... |
DB00238 | DB00959 | 188 | 1,486 | [
"DDInter1285",
"DDInter1191"
] | Nevirapine | Methylprednisolone | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
188,
24,
1486
]
],
[
[
188,
24,
175
],
[
175,
40,
1486
]
],
[
[
188,
24,
1220
],
[
1220,
1,
1486
]
],
[
[
188,
6,
8374
],
[
8374,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Me... |
DB00295 | DB00424 | 475 | 19 | [
"DDInter1244",
"DDInter896"
] | Morphine | Hyoscyamine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Moderate | 1 | [
[
[
475,
24,
19
]
],
[
[
475,
24,
1166
],
[
1166,
1,
19
]
],
[
[
475,
24,
85
],
[
85,
63,
19
]
],
[
[
475,
21,
29093
],
[
29093,
60,... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dolasetron"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Dolasetron and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacer... |
DB01156 | DB01215 | 593 | 1,418 | [
"DDInter252",
"DDInter677"
] | Bupropion | Estazolam | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
593,
24,
1418
]
],
[
[
593,
63,
523
],
[
523,
1,
1418
]
],
[
[
593,
63,
1216
],
[
1216,
40,
1418
]
],
[
[
593,
64,
87
],
[
87,
4... | [
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Bupr... |
DB00191 | DB08824 | 73 | 591 | [
"DDInter1447",
"DDInter959"
] | Phentermine | Ioflupane I-123 | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
73,
24,
591
]
],
[
[
73,
6,
2437
],
[
2437,
45,
591
]
],
[
[
73,
21,
28722
],
[
28722,
60,
591
]
],
[
[
73,
25,
109
],
[
109,
24... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Phentermine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A3"
],
[
"SLC6A3",
"{u} (Gene) is bound by {v} (Comp... | Phentermine (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Ioflupane I-123 (Compound)
Phentermine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ioflupane I-123 (Compound)
Phentermine may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine m... |
DB01076 | DB11760 | 700 | 119 | [
"DDInter133",
"DDInter1742"
] | Atorvastatin | Talazoparib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
700,
24,
119
]
],
[
[
700,
24,
1670
],
[
1670,
24,
119
]
],
[
[
700,
63,
1184
],
[
1184,
24,
119
]
],
[
[
700,
24,
214
],
[
214,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
],
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eliglustat may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Ana... |
DB08896 | DB11866 | 292 | 1,068 | [
"DDInter1576",
"DDInter1618"
] | Regorafenib | Romosozumab | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Romosozumab is a humanized monoclonal antibody indicated for the treatment of osteoperosis in postmenopausal women at high risk of fracture and patients who have failed in other treatments or are intolerant to other osteoperosis therapies. Romosozumab prevents bone resorption and induces the formation of bone though it... | Moderate | 1 | [
[
[
292,
24,
1068
]
],
[
[
292,
40,
79
],
[
79,
24,
1068
]
],
[
[
292,
64,
1618
],
[
1618,
24,
1068
]
],
[
[
292,
63,
1220
],
[
1220,
... | [
[
[
"Regorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romosozumab"
]
],
[
[
"Regorafenib",
"{u} (Compound) resembles {v} (Compound)",
"Sorafenib"
],
[
"Sorafenib",
"{u} may cause a modera... | Regorafenib (Compound) resembles Sorafenib (Compound) and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Romosozumab
Regorafenib may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbat... |
DB00398 | DB01267 | 79 | 519 | [
"DDInter1702",
"DDInter1381"
] | Sorafenib | Paliperidone | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Moderate | 1 | [
[
[
79,
24,
519
]
],
[
[
79,
24,
1664
],
[
1664,
1,
519
]
],
[
[
79,
25,
924
],
[
924,
1,
519
]
],
[
[
79,
6,
5744
],
[
5744,
45,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paliperidone"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Paliperidone (Compound)
Sorafenib may lead to a major life threatening interaction when taken with Iloperidone and Iloperidone (Compound) resembles Paliperidone (Compound)
Sorafenib... |
DB00690 | DB01377 | 1,216 | 1,283 | [
"DDInter762",
"DDInter1119"
] | Flurazepam | Magnesium oxide | A benzodiazepine derivative used mainly as a hypnotic. | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Minor | 0 | [
[
[
1216,
23,
1283
]
],
[
[
1216,
40,
216
],
[
216,
23,
1283
]
],
[
[
1216,
1,
905
],
[
905,
23,
1283
]
],
[
[
1216,
24,
104
],
[
104,
... | [
[
[
"Flurazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium oxide"
]
],
[
[
"Flurazepam",
"{u} (Compound) resembles {v} (Compound)",
"Chlorpromazine"
],
[
"Chlorpromazine",
"{u} may caus... | Flurazepam (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause a minor interaction that can limit clinical effects when taken with Magnesium oxide
Flurazepam (Compound) resembles Lorazepam (Compound) and Lorazepam may cause a minor interaction that can limit clinical effects when taken with Magn... |
DB01155 | DB06699 | 872 | 774 | [
"DDInter813",
"DDInter493"
] | Gemifloxacin | Degarelix | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
872,
24,
774
]
],
[
[
872,
63,
521
],
[
521,
1,
774
]
],
[
[
872,
21,
29232
],
[
29232,
60,
774
]
],
[
[
872,
62,
112
],
[
112,
... | [
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Gemifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
[
... | Gemifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Gemifloxacin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Gemifloxacin may cause a minor interaction t... |
DB00317 | DB08870 | 883 | 850 | [
"DDInter810",
"DDInter228"
] | Gefitinib | Brentuximab vedotin | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
883,
24,
850
]
],
[
[
883,
24,
267
],
[
267,
24,
850
]
],
[
[
883,
24,
1033
],
[
1033,
63,
850
]
],
[
[
883,
63,
847
],
[
847,
2... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
],
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and ... |
DB11817 | DB12267 | 1,259 | 1,476 | [
"DDInter165",
"DDInter233"
] | Baricitinib | Brigatinib | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
1259,
25,
1476
]
],
[
[
1259,
64,
168
],
[
168,
23,
1476
]
],
[
[
1259,
64,
629
],
[
629,
24,
1476
]
],
[
[
1259,
25,
800
],
[
800,
... | [
[
[
"Baricitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Baricitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
"{u}... | Baricitinib may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Baricitinib may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a moderate intera... |
DB00635 | DB01041 | 1,573 | 770 | [
"DDInter1515",
"DDInter1789"
] | Prednisone | Thalidomide | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Major | 2 | [
[
[
1573,
25,
770
]
],
[
[
1573,
5,
11555
],
[
11555,
44,
770
]
],
[
[
1573,
6,
10215
],
[
10215,
45,
770
]
],
[
[
1573,
18,
20113
],
[
20... | [
[
[
"Prednisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Prednisone",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated ... | Prednisone (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compound)
Prednisone (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Thalidomide (Compound)
Prednisone (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Thalidomide... |
DB00604 | DB01764 | 1,425 | 805 | [
"DDInter385",
"DDInter469"
] | Cisapride | Dalfopristin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Major | 2 | [
[
[
1425,
25,
805
]
],
[
[
1425,
6,
8374
],
[
8374,
45,
805
]
],
[
[
1425,
63,
1101
],
[
1101,
23,
805
]
],
[
[
1425,
25,
283
],
[
283,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dalfopristin"
]
],
[
[
"Cisapride",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Dalfopr... | Cisapride (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dalfopristin (Compound)
Cisapride may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Cisapride may lead... |
DB01124 | DB11921 | 1,411 | 1,019 | [
"DDInter1828",
"DDInter492"
] | Tolbutamide | Deflazacort | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
1411,
24,
1019
]
],
[
[
1411,
63,
1072
],
[
1072,
23,
1019
]
],
[
[
1411,
24,
192
],
[
192,
24,
1019
]
],
[
[
1411,
1,
959
],
[
959,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
],
[
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid and Isoniazid may cause a minor interaction that can limit clinical effects when taken with Deflazacort
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens a... |
DB00889 | DB06589 | 1,133 | 1,250 | [
"DDInter840",
"DDInter1400"
] | Granisetron | Pazopanib | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1133,
24,
1250
]
],
[
[
1133,
6,
12523
],
[
12523,
45,
1250
]
],
[
[
1133,
18,
8386
],
[
8386,
46,
1250
]
],
[
[
1133,
7,
2652
],
[
26... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Granisetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Granisetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Pazopanib (Compound)
Granisetron (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Pazopanib (Compound)
Granisetron (Compound) upregulates CASP10 (Gene) and CASP10 (Gene) is downregulated by Pazopanib (Compound)
Granisetro... |
DB00607 | DB15091 | 1,249 | 676 | [
"DDInter1256",
"DDInter1901"
] | Nafcillin | Upadacitinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
1249,
24,
676
]
],
[
[
1249,
25,
283
],
[
283,
24,
676
]
],
[
[
1249,
24,
1593
],
[
1593,
24,
676
]
],
[
[
1249,
63,
597
],
[
597,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Nafcillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
],
[
"Fedratinib... | Nafcillin may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause ... |
DB09073 | DB10795 | 951 | 221 | [
"DDInter1379",
"DDInter1486"
] | Palbociclib | Poliovirus type 1 antigen (formaldehyde inactivated) | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
951,
24,
221
]
],
[
[
951,
64,
581
],
[
581,
24,
221
]
],
[
[
951,
63,
599
],
[
599,
24,
221
]
],
[
[
951,
24,
351
],
[
351,
63,... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Palbociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Palbociclib may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Palbociclib may cause a moderate interaction that could exacerbate diseases when tak... |
DB00679 | DB09078 | 684 | 1,228 | [
"DDInter1796",
"DDInter1036"
] | Thioridazine | Lenvatinib | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
684,
25,
1228
]
],
[
[
684,
23,
112
],
[
112,
23,
1228
]
],
[
[
684,
25,
609
],
[
609,
24,
1228
]
],
[
[
684,
24,
770
],
[
770,
... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Thioridazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Thioridazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Thioridazine may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromy... |
DB00601 | DB06674 | 453 | 908 | [
"DDInter1073",
"DDInter837"
] | Linezolid | Golimumab | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
453,
25,
908
]
],
[
[
453,
63,
268
],
[
268,
24,
908
]
],
[
[
453,
24,
458
],
[
458,
24,
908
]
],
[
[
453,
24,
1430
],
[
1430,
6... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon alfa-2b"
],
[
"Pe... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b and Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Ti... |
DB01023 | DB11569 | 409 | 1,093 | [
"DDInter716",
"DDInter1003"
] | Felodipine | Ixekizumab | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Ixekizumab is a humanized immunoglobulin G subclass 4 (IgG4) monoclonal antibody (mAb) against interleukin-17A (IL-17A) and prevents it from interacting with the IL-17A receptor. As IL-17A is a pro-inflammatory cytokine involved in inflammation and immune responses, blocking its effect is beneficial for use in inflamma... | Moderate | 1 | [
[
[
409,
24,
1093
]
],
[
[
409,
24,
1683
],
[
1683,
24,
1093
]
],
[
[
409,
1,
376
],
[
376,
24,
1093
]
],
[
[
409,
40,
854
],
[
854,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixekizumab"
]
],
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[
... | Felodipine may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Ixekizumab
Felodipine (Compound) resembles Amlodipine (Compound) and Amlodipine may cause a moderate interaction that cou... |
DB00554 | DB04932 | 1,027 | 1,564 | [
"DDInter1478",
"DDInter491"
] | Piroxicam | Defibrotide | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
1027,
24,
1564
]
],
[
[
1027,
24,
1039
],
[
1039,
24,
1564
]
],
[
[
1027,
40,
1171
],
[
1171,
24,
1564
]
],
[
[
1027,
24,
738
],
[
738... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
... | Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Piroxicam (Compound) resembles Meloxicam (Compound) and Meloxicam may cause a moderate interaction tha... |
DB01041 | DB11718 | 770 | 927 | [
"DDInter1789",
"DDInter640"
] | Thalidomide | Encorafenib | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
770,
24,
927
]
],
[
[
770,
63,
112
],
[
112,
23,
927
]
],
[
[
770,
63,
216
],
[
216,
24,
927
]
],
[
[
770,
24,
495
],
[
495,
24,... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Encorafenib
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine... |
DB08912 | DB08938 | 1,040 | 1,384 | [
"DDInter462",
"DDInter1112"
] | Dabrafenib | Magaldrate | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
1040,
24,
1384
]
],
[
[
1040,
63,
167
],
[
167,
23,
1384
]
],
[
[
1040,
64,
263
],
[
263,
23,
1384
]
],
[
[
1040,
24,
405
],
[
405,
... | [
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Dabrafenib may lead to a major life threatening interaction when taken with Axitinib and Axitinib may caus... |
DB00312 | DB06691 | 1,023 | 849 | [
"DDInter1423",
"DDInter1155"
] | Pentobarbital | Mepyramine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1023,
24,
849
]
],
[
[
1023,
24,
1594
],
[
1594,
24,
849
]
],
[
[
1023,
63,
1648
],
[
1648,
24,
849
]
],
[
[
1023,
24,
407
],
[
407,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and... |
DB00451 | DB01136 | 542 | 772 | [
"DDInter1064",
"DDInter305"
] | Levothyroxine | Carvedilol | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Minor | 0 | [
[
[
542,
23,
772
]
],
[
[
542,
6,
4973
],
[
4973,
45,
772
]
],
[
[
542,
18,
2183
],
[
2183,
57,
772
]
],
[
[
542,
21,
29118
],
[
29118,
... | [
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Carvedilol"
]
],
[
[
"Levothyroxine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Levothyroxine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Carvedilol (Compound)
Levothyroxine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Carvedilol (Compound)
Levothyroxine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Carvedilol (C... |
DB00696 | DB12010 | 826 | 214 | [
"DDInter665",
"DDInter785"
] | Ergotamine | Fostamatinib | A vasoconstrictor found in ergot of Central Europe. It is an alpha-1 selective adrenergic agonist and is commonly used in the treatment of migraine disorders. | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
826,
24,
214
]
],
[
[
826,
63,
723
],
[
723,
24,
214
]
],
[
[
826,
24,
1250
],
[
1250,
24,
214
]
],
[
[
826,
40,
588
],
[
588,
2... | [
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Ergotamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Ergotamine may cause a moderate interaction that could exacerbate diseases when taken with Pazopanib and Pazop... |
DB09073 | DB12301 | 951 | 907 | [
"DDInter1379",
"DDInter585"
] | Palbociclib | Doravirine | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Minor | 0 | [
[
[
951,
23,
907
]
],
[
[
951,
63,
1478
],
[
1478,
23,
907
]
],
[
[
951,
24,
159
],
[
159,
62,
907
]
],
[
[
951,
24,
351
],
[
351,
2... | [
[
[
"Palbociclib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
]
],
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a minor interaction that can limit clinical effects when taken with Doravirine
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larot... |
DB01254 | DB12095 | 1,213 | 179 | [
"DDInter484",
"DDInter1760"
] | Dasatinib | Telotristat ethyl | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
1213,
24,
179
]
],
[
[
1213,
63,
79
],
[
79,
24,
179
]
],
[
[
1213,
24,
310
],
[
310,
24,
179
]
],
[
[
1213,
64,
1493
],
[
1493,
... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Ca... |
DB08931 | DB09065 | 947 | 760 | [
"DDInter1600",
"DDInter424"
] | Riociguat | Cobicistat | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
947,
25,
760
]
],
[
[
947,
63,
1101
],
[
1101,
23,
760
]
],
[
[
947,
63,
1195
],
[
1195,
24,
760
]
],
[
[
947,
24,
1033
],
[
1033,
... | [
[
[
"Riociguat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Riociguat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",... | Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Riociguat may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib m... |
DB00987 | DB12674 | 1,224 | 975 | [
"DDInter461",
"DDInter1105"
] | Cytarabine (liposomal) | Lurbinectedin | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1224,
24,
975
]
],
[
[
1224,
35,
1488
],
[
1488,
24,
975
]
],
[
[
1224,
24,
1613
],
[
1613,
24,
975
]
],
[
[
1224,
74,
372
],
[
372,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Cytarabine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when take... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Cytarabine (Compound) resembles Fludarabine (Compound) and Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that... |
DB00556 | DB00836 | 1,262 | 543 | [
"DDInter1429",
"DDInter1088"
] | Perflutren | Loperamide | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
1262,
24,
543
]
],
[
[
1262,
24,
888
],
[
888,
24,
543
]
],
[
[
1262,
21,
28722
],
[
28722,
60,
543
]
],
[
[
1262,
63,
79
],
[
79,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
],
[
... | Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Perflutren (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Loperamide (Compound)
Perf... |
DB00371 | DB00719 | 1,050 | 1,219 | [
"DDInter1154",
"DDInter149"
] | Meprobamate | Azatadine | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
1050,
24,
1219
]
],
[
[
1050,
24,
13
],
[
13,
24,
1219
]
],
[
[
1050,
24,
830
],
[
830,
1,
1219
]
],
[
[
1050,
24,
1376
],
[
1376,
... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine... |
DB00852 | DB09043 | 1,445 | 135 | [
"DDInter1545",
"DDInter36"
] | Pseudoephedrine | Albiglutide | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Albiglutide is a glucagon-like peptide-1 agonist (GLP-1) biologic drug indicated in the treatment of type 2 diabetes. It is marketed under the brands Eperzan and Tanzeum by GSK (GlaxoSmithKline). It is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide was approved on A... | Moderate | 1 | [
[
[
1445,
24,
135
]
],
[
[
1445,
63,
1252
],
[
1252,
23,
135
]
],
[
[
1445,
24,
1052
],
[
1052,
24,
135
]
],
[
[
1445,
24,
320
],
[
320,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
]
],
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
],
... | Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Albiglutide
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Rito... |
DB00860 | DB12130 | 891 | 1,017 | [
"DDInter1513",
"DDInter1094"
] | Prednisolone | Lorlatinib | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
891,
24,
1017
]
],
[
[
891,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
891,
63,
590
],
[
590,
24,
1017
]
],
[
[
891,
1,
175
],
[
175,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide and A... |
DB00180 | DB00242 | 1,351 | 1,064 | [
"DDInter749",
"DDInter392"
] | Flunisolide | Cladribine | Flunisolide (marketed as AeroBid, Nasalide, Nasarel) is a corticosteroid with anti-inflammatory actions. It is often prescribed as treatment for allergic rhinitis and its principle mechanism of action involves activation of glucocorticoid receptors. | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Major | 2 | [
[
[
1351,
25,
1064
]
],
[
[
1351,
18,
4071
],
[
4071,
45,
1064
]
],
[
[
1351,
7,
2475
],
[
2475,
46,
1064
]
],
[
[
1351,
18,
20113
],
[
20... | [
[
[
"Flunisolide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
]
],
[
[
"Flunisolide",
"{u} (Compound) downregulates {v} (Gene)",
"PNP"
],
[
"PNP",
"{u} (Gene) is bound by {v} (Compound)",
"Cla... | Flunisolide (Compound) downregulates PNP (Gene) and PNP (Gene) is bound by Cladribine (Compound)
Flunisolide (Compound) upregulates RGS2 (Gene) and RGS2 (Gene) is upregulated by Cladribine (Compound)
Flunisolide (Compound) downregulates IER3 (Gene) and IER3 (Gene) is upregulated by Cladribine (Compound)
Flunisolide (Co... |
DB00350 | DB00601 | 1,214 | 453 | [
"DDInter1226",
"DDInter1073"
] | Minoxidil | Linezolid | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Moderate | 1 | [
[
[
1214,
24,
453
]
],
[
[
1214,
24,
849
],
[
849,
63,
453
]
],
[
[
1214,
24,
999
],
[
999,
24,
453
]
],
[
[
1214,
63,
1648
],
[
1648,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linezolid"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Linezolid
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thi... |
DB00539 | DB12130 | 11 | 1,017 | [
"DDInter1837",
"DDInter1094"
] | Toremifene | Lorlatinib | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
11,
24,
1017
]
],
[
[
11,
25,
1612
],
[
1612,
23,
1017
]
],
[
[
11,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
11,
25,
786
],
[
786,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fostemsavir"
],
[
"Fostemsav... | Toremifene may lead to a major life threatening interaction when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause ... |
DB01118 | DB04868 | 33 | 478 | [
"DDInter76",
"DDInter1293"
] | Amiodarone | Nilotinib | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
33,
25,
478
]
],
[
[
33,
24,
1468
],
[
1468,
63,
478
]
],
[
[
33,
6,
6017
],
[
6017,
45,
478
]
],
[
[
33,
7,
2703
],
[
2703,
46,... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib
Amiodarone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Nilotinib (Compound)
Amiodarone (Compound) ... |
DB00193 | DB00398 | 534 | 79 | [
"DDInter1841",
"DDInter1702"
] | Tramadol | Sorafenib | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Moderate | 1 | [
[
[
534,
24,
79
]
],
[
[
534,
6,
7603
],
[
7603,
45,
79
]
],
[
[
534,
18,
18226
],
[
18226,
46,
79
]
],
[
[
534,
18,
3684
],
[
3684,
... | [
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
]
],
[
[
"Tramadol",
"{u} (Compound) binds {v} (Gene)",
"CYP2B6"
],
[
"CYP2B6",
"{u} (Gene) is bound by {v} (Compound)",
... | Tramadol (Compound) binds CYP2B6 (Gene) and CYP2B6 (Gene) is bound by Sorafenib (Compound)
Tramadol (Compound) downregulates GDF15 (Gene) and GDF15 (Gene) is upregulated by Sorafenib (Compound)
Tramadol (Compound) downregulates PGAM1 (Gene) and PGAM1 (Gene) is downregulated by Sorafenib (Compound)
Tramadol (Compound) c... |
DB06705 | DB08946 | 1,106 | 512 | [
"DDInter795",
"DDInter962"
] | Gadofosveset trisodium | Iopanoic acid | Gadofosveset trisodium is an intravenous contrast agent used with magnetic resonance angiography(MRA), which is a non-invasive way of imaging blood vessels. The agent allows for the vascular system to be imaged more clearly by the MRA. In this way, gadofosveset trisodium is used to help diagnose certain disorders of th... | Iopanoic acid contains iodine and is useful as a contrast medium in cholecystography. | Moderate | 1 | [
[
[
1106,
24,
512
]
],
[
[
1106,
63,
1592
],
[
1592,
24,
512
]
],
[
[
1106,
63,
1592
],
[
1592,
24,
619
],
[
619,
24,
512
]
],
[
[
1106,
... | [
[
[
"Gadofosveset trisodium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopanoic acid"
]
],
[
[
"Gadofosveset trisodium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"... | Gadofosveset trisodium may cause a moderate interaction that could exacerbate diseases when taken with Nebivolol and Nebivolol may cause a moderate interaction that could exacerbate diseases when taken with Iopanoic acid
Gadofosveset trisodium may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00530 | DB00872 | 1,195 | 1,080 | [
"DDInter667",
"DDInter438"
] | Erlotinib | Conivaptan | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Moderate | 1 | [
[
[
1195,
24,
1080
]
],
[
[
1195,
24,
165
],
[
165,
40,
1080
]
],
[
[
1195,
25,
990
],
[
990,
40,
1080
]
],
[
[
1195,
6,
8374
],
[
8374,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Tolvaptan and Tolvaptan (Compound) resembles Conivaptan (Compound)
Erlotinib may lead to a major life threatening interaction when taken with Lomitapide and Lomitapide (Compound) resembles Conivaptan (Compound)
Erlotinib (Compound... |
DB00204 | DB09054 | 228 | 384 | [
"DDInter580",
"DDInter905"
] | Dofetilide | Idelalisib | Dofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
228,
24,
384
]
],
[
[
228,
25,
1618
],
[
1618,
24,
384
]
],
[
[
228,
23,
891
],
[
891,
24,
384
]
],
[
[
228,
64,
600
],
[
600,
2... | [
[
[
"Dofetilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Dofetilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
],
[
"Cabozant... | Dofetilide may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Dofetilide may cause a minor interaction that can limit clinical effects when taken with Prednisolone and Prednisolone may ... |
DB00889 | DB00976 | 1,133 | 1,056 | [
"DDInter840",
"DDInter1758"
] | Granisetron | Telithromycin | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
1133,
24,
1056
]
],
[
[
1133,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
1133,
6,
7524
],
[
7524,
45,
1056
]
],
[
[
1133,
21,
28681
],
[
28... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],
... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Granisetron (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Telithromycin (Compound)
Granisetron (Compound) causes Hypersensitivity (Side E... |
DB00549 | DB15233 | 522 | 1,650 | [
"DDInter1955",
"DDInter142"
] | Zafirlukast | Avapritinib | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
522,
24,
1650
]
],
[
[
522,
24,
1478
],
[
1478,
24,
1650
]
],
[
[
522,
23,
222
],
[
222,
24,
1650
]
],
[
[
522,
24,
908
],
[
908,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Zafirlukast may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutr... |
DB00816 | DB08899 | 1,674 | 129 | [
"DDInter1346",
"DDInter649"
] | Orciprenaline | Enzalutamide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1674,
24,
129
]
],
[
[
1674,
24,
918
],
[
918,
1,
129
]
],
[
[
1674,
21,
28703
],
[
28703,
60,
129
]
],
[
[
1674,
24,
230
],
[
230,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Orciprenaline (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Orciprenaline may cause a modera... |
DB00860 | DB09104 | 891 | 286 | [
"DDInter1513",
"DDInter1118"
] | Prednisolone | Magnesium hydroxide | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
891,
24,
286
]
],
[
[
891,
24,
1482
],
[
1482,
23,
286
]
],
[
[
891,
63,
88
],
[
88,
23,
286
]
],
[
[
891,
62,
1382
],
[
1382,
2... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol a... |
DB00081 | DB00285 | 273 | 1,100 | [
"DDInter1838",
"DDInter1927"
] | Tositumomab | Venlafaxine | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Moderate | 1 | [
[
[
273,
24,
1100
]
],
[
[
273,
24,
643
],
[
643,
40,
1100
]
],
[
[
273,
64,
366
],
[
366,
24,
1100
]
],
[
[
273,
25,
126
],
[
126,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Venlafaxine"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
],
... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine (Compound) resembles Venlafaxine (Compound)
Tositumomab may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could... |
DB06077 | DB09038 | 879 | 1,450 | [
"DDInter1102",
"DDInter636"
] | Lumateperone | Empagliflozin | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
879,
24,
1450
]
],
[
[
879,
63,
1179
],
[
1179,
24,
1450
]
],
[
[
879,
25,
1017
],
[
1017,
63,
1450
]
],
[
[
879,
24,
1296
],
[
1296,
... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin lispro"
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Insulin lispro and Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Lumateperone may lead to a major life threatening interaction when taken with Lorlatinib and Lorlat... |
DB06772 | DB10343 | 310 | 962 | [
"DDInter259",
"DDInter160"
] | Cabazitaxel | Bacillus calmette-guerin substrain tice live antigen | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
310,
25,
962
]
],
[
[
310,
64,
1057
],
[
1057,
25,
962
]
],
[
[
310,
63,
1213
],
[
1213,
25,
962
]
],
[
[
310,
24,
270
],
[
270,
... | [
[
[
"Cabazitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Cabazitaxel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
... | Cabazitaxel may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Dasatin... |
DB00687 | DB01064 | 870 | 1,148 | [
"DDInter747",
"DDInter987"
] | Fludrocortisone | Isoprenaline | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Minor | 0 | [
[
[
870,
23,
1148
]
],
[
[
870,
23,
480
],
[
480,
24,
1148
]
],
[
[
870,
63,
1523
],
[
1523,
24,
1148
]
],
[
[
870,
24,
887
],
[
887,
... | [
[
[
"Fludrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Isoprenaline"
]
],
[
[
"Fludrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Formoterol"
],
... | Fludrocortisone may cause a minor interaction that can limit clinical effects when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol a... |
DB00030 | DB09068 | 1,685 | 1,427 | [
"DDInter934",
"DDInter1948"
] | Insulin human | Vortioxetine | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Moderate | 1 | [
[
[
1685,
24,
1427
]
],
[
[
1685,
24,
1220
],
[
1220,
24,
1427
]
],
[
[
1685,
24,
73
],
[
73,
25,
1427
]
],
[
[
1685,
24,
1220
],
[
1220,
... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vortioxetine"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Phenter... |
DB06603 | DB14409 | 39 | 1,129 | [
"DDInter1387",
"DDInter867"
] | Panobinostat | Human adenovirus e serotype 4 strain cl-68578 antigen | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
39,
24,
1129
]
],
[
[
39,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
39,
63,
1683
],
[
1683,
24,
1129
]
],
[
[
39,
25,
1468
],
[
1468,
... | [
[
[
"Panobinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Panobinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Panobinostat may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Panobinostat may cause a moderate interaction that could exacerbate diseases when ... |
DB00205 | DB08938 | 929 | 1,384 | [
"DDInter1550",
"DDInter1112"
] | Pyrimethamine | Magaldrate | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
929,
24,
1384
]
],
[
[
929,
25,
1292
],
[
1292,
24,
1384
]
],
[
[
929,
24,
1243
],
[
1243,
24,
1384
]
],
[
[
929,
25,
1292
],
[
1292,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Pyrimethamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
],
[
"Def... | Pyrimethamine may lead to a major life threatening interaction when taken with Deferiprone and Deferiprone may cause a moderate interaction that could exacerbate diseases when taken with Magaldrate
Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Proguanil and Proguanil may ... |
DB00741 | DB01193 | 167 | 819 | [
"DDInter885",
"DDInter12"
] | Hydrocortisone | Acebutolol | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
167,
24,
819
]
],
[
[
167,
24,
887
],
[
887,
1,
819
]
],
[
[
167,
63,
1121
],
[
1121,
1,
819
]
],
[
[
167,
6,
4973
],
[
4973,
45... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Bisoprolol and Bisoprolol (Compound) resembles Acebutolol (Compou... |
DB00675 | DB14730 | 888 | 1,412 | [
"DDInter1744",
"DDInter264"
] | Tamoxifen | Calaspargase pegol | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
888,
24,
1412
]
],
[
[
888,
24,
159
],
[
159,
24,
1412
]
],
[
[
888,
23,
1347
],
[
1347,
24,
1412
]
],
[
[
888,
63,
322
],
[
322,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Clopidogrel... |
DB01284 | DB06718 | 1,042 | 1,687 | [
"DDInter1782",
"DDInter1709"
] | Tetracosactide | Stanozolol | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
1042,
24,
1687
]
],
[
[
1042,
24,
1546
],
[
1546,
1,
1687
]
],
[
[
1042,
63,
1561
],
[
1561,
40,
1687
]
],
[
[
1042,
63,
155
],
[
155,... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone (Compound) rese... |
DB00104 | DB11757 | 966 | 960 | [
"DDInter1323",
"DDInter994"
] | Octreotide | Istradefylline | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Istradefylline, or KW6002, was developed by Kyowa Hakko Kirin in Japan for the treatment of Parkinson's disease as an adjunct to standard therapy. Unlike standard dopaminergic therapies for Parkinson's, Istradefylline targets adenosine A<sub>2A</sub> receptors in the basal ganglia. This region of the brain is highly in... | Moderate | 1 | [
[
[
966,
24,
960
]
],
[
[
966,
24,
971
],
[
971,
63,
960
]
],
[
[
966,
40,
1154
],
[
1154,
24,
960
]
],
[
[
966,
24,
351
],
[
351,
2... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Istradefylline"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
],
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Gilteritinib and Gilteritinib may cause a moderate interaction that could exacerbate diseases when taken with Istradefylline
Octreotide (Compound) resembles Pasireotide (Compound) and Pasireotide may cause a moderate interaction ... |
DB00030 | DB00685 | 1,685 | 1,299 | [
"DDInter934",
"DDInter1887"
] | Insulin human | Trovafloxacin | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Major | 2 | [
[
[
1685,
25,
1299
]
],
[
[
1685,
25,
872
],
[
872,
40,
1299
]
],
[
[
1685,
24,
1479
],
[
1479,
63,
1299
]
],
[
[
1685,
24,
1560
],
[
1560... | [
[
[
"Insulin human",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Insulin human",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gemifloxacin"
],
[
"Gemifloxacin",... | Insulin human may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate inte... |
DB00888 | DB11988 | 1,001 | 270 | [
"DDInter1133",
"DDInter1321"
] | Mechlorethamine | Ocrelizumab | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1001,
24,
270
]
],
[
[
1001,
63,
1461
],
[
1461,
23,
270
]
],
[
[
1001,
63,
134
],
[
134,
24,
270
]
],
[
[
1001,
24,
713
],
[
713,
... | [
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Mechlorethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
]... | Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Mechlorethamine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine an... |
DB01359 | DB09156 | 729 | 777 | [
"DDInter1417",
"DDInter964"
] | Penbutolol | Iopromide | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Iopromide is a low osmolar, non-ionic X-ray contrast agent for intravascular administration. It functions as a contrast agent by opacifying blood vessels in the flow path of the contrast agent, permitting radiographic visualization of the internal structures until significant hemodilution occurs. Although iopromide can... | Moderate | 1 | [
[
[
729,
24,
777
]
],
[
[
729,
40,
461
],
[
461,
24,
777
]
],
[
[
729,
63,
1648
],
[
1648,
24,
777
]
],
[
[
729,
1,
668
],
[
668,
24... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iopromide"
]
],
[
[
"Penbutolol",
"{u} (Compound) resembles {v} (Compound)",
"Timolol"
],
[
"Timolol",
"{u} may cause a moderate inter... | Penbutolol (Compound) resembles Timolol (Compound) and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Iopromide
Penbutolol may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exac... |
DB00010 | DB06655 | 1,649 | 5 | [
"DDInter1661",
"DDInter1077"
] | Sermorelin | Liraglutide | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1649,
24,
5
]
],
[
[
1649,
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245
],
[
245,
24,
5
]
],
[
[
1649,
24,
1296
],
[
1296,
63,
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]
],
[
[
1649,
24,
245
],
[
245,
23,... | [
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Sermorelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Sermorelin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec a... |
DB01041 | DB01218 | 770 | 1,493 | [
"DDInter1789",
"DDInter852"
] | Thalidomide | Halofantrine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Moderate | 1 | [
[
[
770,
24,
1493
]
],
[
[
770,
6,
7524
],
[
7524,
45,
1493
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[
[
770,
21,
28810
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[
28810,
60,
1493
]
],
[
[
770,
63,
479
],
[
479,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Halofantrine"
]
],
[
[
"Thalidomide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compoun... | Thalidomide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Halofantrine (Compound)
Thalidomide (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when... |
DB00555 | DB01083 | 706 | 1,142 | [
"DDInter1020",
"DDInter1348"
] | Lamotrigine | Orlistat | Lamotrigine is an antiepileptic drug belonging in the phenyltriazine class. It is used in the treatment of both epilepsy and as a mood stabilizer in bipolar disorder. Lamotrigine is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. It... | The global prevalence of obesity is increasing rapidly. Obesity-related complications lead to significant personal and economic burden by reducing quality of life and increasing the cost of healthcare. In some individuals, diet and exercise are insufficient to maintain weight loss, and pharmacological or surgical inter... | Moderate | 1 | [
[
[
706,
24,
1142
]
],
[
[
706,
21,
28916
],
[
28916,
60,
1142
]
],
[
[
706,
62,
1645
],
[
1645,
24,
1142
]
],
[
[
706,
23,
663
],
[
663,
... | [
[
[
"Lamotrigine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orlistat"
]
],
[
[
"Lamotrigine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypothyroidism"
],
[
"Hypothyroidism",
"{u} (Side Effec... | Lamotrigine (Compound) causes Hypothyroidism (Side Effect) and Hypothyroidism (Side Effect) is caused by Orlistat (Compound)
Lamotrigine may cause a minor interaction that can limit clinical effects when taken with Metformin and Metformin may cause a moderate interaction that could exacerbate diseases when taken with O... |
DB00420 | DB00486 | 508 | 1,614 | [
"DDInter1532",
"DDInter1253"
] | Promazine | Nabilone | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
508,
24,
1614
]
],
[
[
508,
24,
530
],
[
530,
1,
1614
]
],
[
[
508,
24,
516
],
[
516,
63,
1614
]
],
[
[
508,
25,
1311
],
[
1311,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
[
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and Levocetirizine may cause a moderate interaction that c... |
DB00250 | DB09098 | 10 | 98 | [
"DDInter475",
"DDInter1700"
] | Dapsone | Somatrem | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
10,
24,
98
]
],
[
[
10,
63,
168
],
[
168,
23,
98
]
],
[
[
10,
24,
671
],
[
671,
24,
98
]
],
[
[
10,
24,
1375
],
[
1375,
63,
... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
"Bor... | Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may... |
DB00353 | DB12130 | 588 | 1,017 | [
"DDInter1187",
"DDInter1094"
] | Methylergometrine | Lorlatinib | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
588,
24,
1017
]
],
[
[
588,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
588,
24,
1446
],
[
1446,
24,
1017
]
],
[
[
588,
24,
159
],
[
159,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Lanreotid... |
DB00370 | DB00501 | 1,251 | 752 | [
"DDInter1230",
"DDInter380"
] | Mirtazapine | Cimetidine | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Moderate | 1 | [
[
[
1251,
24,
752
]
],
[
[
1251,
6,
7950
],
[
7950,
45,
752
]
],
[
[
1251,
21,
29134
],
[
29134,
60,
752
]
],
[
[
1251,
23,
112
],
[
112,
... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
]
],
[
[
"Mirtazapine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)... | Mirtazapine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Cimetidine (Compound)
Mirtazapine (Compound) causes Flatulence (Side Effect) and Flatulence (Side Effect) is caused by Cimetidine (Compound)
Mirtazapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole an... |
DB00334 | DB00675 | 867 | 888 | [
"DDInter1326",
"DDInter1744"
] | Olanzapine | Tamoxifen | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
867,
24,
888
]
],
[
[
867,
24,
832
],
[
832,
40,
888
]
],
[
[
867,
24,
543
],
[
543,
63,
888
]
],
[
[
867,
24,
649
],
[
649,
1,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
[... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine (Compound) resembles Tamoxifen (Compound)
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction tha... |
DB00950 | DB08899 | 1,413 | 129 | [
"DDInter732",
"DDInter649"
] | Fexofenadine | Enzalutamide | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1413,
24,
129
]
],
[
[
1413,
6,
12523
],
[
12523,
45,
129
]
],
[
[
1413,
21,
28703
],
[
28703,
60,
129
]
],
[
[
1413,
24,
1510
],
[
15... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Fexofenadine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compo... | Fexofenadine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Enzalutamide (Compound)
Fexofenadine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomi... |
DB00014 | DB06663 | 521 | 1,154 | [
"DDInter839",
"DDInter1398"
] | Goserelin | Pasireotide | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
521,
25,
1154
]
],
[
[
521,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
521,
23,
112
],
[
112,
23,
1154
]
],
[
[
521,
24,
1385
],
[
1385,
... | [
[
[
"Goserelin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Goserelin",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused by ... | Goserelin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Goserelin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken w... |
DB00987 | DB14443 | 1,224 | 987 | [
"DDInter460",
"DDInter1931"
] | Cytarabine | Vibrio cholerae CVD 103-HgR strain live antigen | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1224,
24,
987
]
],
[
[
1224,
63,
141
],
[
141,
24,
987
]
],
[
[
1224,
40,
1426
],
[
1426,
24,
987
]
],
[
[
1224,
35,
1488
],
[
1488,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Cytarabine (Compound) resembles Azacitidine (Compound) and Azacitidine ma... |
DB00687 | DB01197 | 870 | 1,603 | [
"DDInter747",
"DDInter292"
] | Fludrocortisone | Captopril | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment ... | Moderate | 1 | [
[
[
870,
24,
1603
]
],
[
[
870,
63,
610
],
[
610,
1,
1603
]
],
[
[
870,
21,
30552
],
[
30552,
60,
1603
]
],
[
[
870,
24,
286
],
[
286,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Captopril"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enalapril"
],
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Enalapril and Enalapril (Compound) resembles Captopril (Compound)
Fludrocortisone (Compound) causes Diabetic (Side Effect) and Diabetic (Side Effect) is caused by Captopril (Compound)
Fludrocortisone may cause a moderate int... |
DB00015 | DB04932 | 582 | 1,564 | [
"DDInter1585",
"DDInter491"
] | Reteplase | Defibrotide | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Major | 2 | [
[
[
582,
25,
1564
]
],
[
[
582,
23,
297
],
[
297,
62,
1564
]
],
[
[
582,
24,
914
],
[
914,
24,
1564
]
],
[
[
582,
24,
41
],
[
41,
63... | [
[
[
"Reteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Defibrotide"
]
],
[
[
"Reteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{u}... | Reteplase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Defibrotide
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause ... |
DB00683 | DB08938 | 1,382 | 1,384 | [
"DDInter1212",
"DDInter1112"
] | Midazolam | Magaldrate | Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties. It belongs to a class of drugs called _benzodiazepines_. This drug is unique from others in this class due to its rapid onset of effects and short duration of action. Midazola... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
1382,
23,
1384
]
],
[
[
1382,
23,
891
],
[
891,
23,
1384
]
],
[
[
1382,
62,
1573
],
[
1573,
23,
1384
]
],
[
[
1382,
63,
752
],
[
752,
... | [
[
[
"Midazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Midazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Prednisolone"
],
[
... | Midazolam may cause a minor interaction that can limit clinical effects when taken with Prednisolone and Prednisolone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Midazolam may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone... |
DB01181 | DB12674 | 1,532 | 975 | [
"DDInter906",
"DDInter1105"
] | Ifosfamide | Lurbinectedin | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Moderate | 1 | [
[
[
1532,
24,
975
]
],
[
[
1532,
63,
1488
],
[
1488,
24,
975
]
],
[
[
1532,
24,
98
],
[
98,
24,
975
]
],
[
[
1532,
74,
450
],
[
450,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Som... |
DB01403 | DB09104 | 9 | 286 | [
"DDInter1175",
"DDInter1118"
] | Methotrimeprazine | Magnesium hydroxide | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
9,
24,
286
]
],
[
[
9,
1,
820
],
[
820,
23,
286
]
],
[
[
9,
63,
401
],
[
401,
23,
286
]
],
[
[
9,
63,
688
],
[
688,
24,
28... | [
[
[
"Methotrimeprazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Methotrimeprazine",
"{u} (Compound) resembles {v} (Compound)",
"Alimemazine"
],
[
"Alimemazine",
... | Methotrimeprazine (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Methotrimeprazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a mino... |
DB00621 | DB00704 | 1,026 | 267 | [
"DDInter1357",
"DDInter1263"
] | Oxandrolone | Naltrexone | A synthetic hormone with anabolic and androgenic properties. | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Moderate | 1 | [
[
[
1026,
24,
267
]
],
[
[
1026,
21,
29463
],
[
29463,
60,
267
]
],
[
[
1026,
24,
850
],
[
850,
63,
267
]
],
[
[
1026,
40,
984
],
[
984,
... | [
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naltrexone"
]
],
[
[
"Oxandrolone",
"{u} (Compound) causes {v} (Side Effect)",
"Bronchial hyperreactivity"
],
[
"Bronchial hyperreactivity"... | Oxandrolone (Compound) causes Bronchial hyperreactivity (Side Effect) and Bronchial hyperreactivity (Side Effect) is caused by Naltrexone (Compound)
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction th... |
DB01021 | DB09112 | 674 | 1,455 | [
"DDInter1861",
"DDInter1306"
] | Trichlormethiazide | Nitrous acid | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Nitrous acid (as sodium nitrite) is used as part of an intravenous mixture with sodium thiosulfate to treat cyanide poisoning. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system. There is also research to investigate its applica... | Moderate | 1 | [
[
[
674,
24,
1455
]
],
[
[
674,
1,
1577
],
[
1577,
24,
1455
]
],
[
[
674,
24,
1450
],
[
1450,
24,
1455
]
],
[
[
674,
40,
504
],
[
504,
... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitrous acid"
]
],
[
[
"Trichlormethiazide",
"{u} (Compound) resembles {v} (Compound)",
"Hydroflumethiazide"
],
[
"Hydroflumethiazid... | Trichlormethiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Nitrous acid
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may... |
DB00912 | DB01250 | 473 | 712 | [
"DDInter1581",
"DDInter1334"
] | Repaglinide | Olsalazine | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
473,
24,
712
]
],
[
[
473,
63,
50
],
[
50,
40,
712
]
],
[
[
473,
63,
914
],
[
914,
24,
712
]
],
[
[
473,
6,
4789
],
[
4789,
45,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction th... |
DB06273 | DB08870 | 980 | 850 | [
"DDInter1824",
"DDInter228"
] | Tocilizumab | Brentuximab vedotin | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
980,
24,
850
]
],
[
[
980,
24,
788
],
[
788,
24,
850
]
],
[
[
980,
63,
671
],
[
671,
24,
850
]
],
[
[
980,
24,
496
],
[
496,
63,... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Fluvas... |
DB00214 | DB00414 | 1,028 | 590 | [
"DDInter1836",
"DDInter16"
] | Torasemide | Acetohexamide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
1028,
24,
590
]
],
[
[
1028,
24,
660
],
[
660,
62,
590
]
],
[
[
1028,
24,
1017
],
[
1017,
63,
590
]
],
[
[
1028,
24,
254
],
[
254,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esomeprazole"
],
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Acetohexamide
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and L... |
DB00758 | DB06605 | 1,347 | 1,409 | [
"DDInter413",
"DDInter108"
] | Clopidogrel | Apixaban | Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recen... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
1347,
25,
1409
]
],
[
[
1347,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
1347,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
1347,
23,
539
],
[
53... | [
[
[
"Clopidogrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Clopidogrel",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound)",
"Apixaba... | Clopidogrel (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Clopidogrel (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Clopidogrel may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicu... |
DB00163 | DB11921 | 1,461 | 1,019 | [
"DDInter1943",
"DDInter492"
] | Vitamin E | Deflazacort | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Minor | 0 | [
[
[
1461,
23,
1019
]
],
[
[
1461,
23,
270
],
[
270,
63,
1019
]
],
[
[
1461,
23,
629
],
[
629,
24,
1019
]
],
[
[
1461,
62,
1184
],
[
1184,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Deflazacort"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ocrelizumab"
],
[
... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Sirolimus and Sirolimus ... |
DB01072 | DB08899 | 915 | 129 | [
"DDInter129",
"DDInter649"
] | Atazanavir | Enzalutamide | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
915,
24,
129
]
],
[
[
915,
6,
8374
],
[
8374,
45,
129
]
],
[
[
915,
21,
28703
],
[
28703,
60,
129
]
],
[
[
915,
63,
608
],
[
608,
... | [
[
[
"Atazanavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Atazanavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Atazanavir (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Atazanavir (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Atazanavir may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lid... |
DB01211 | DB01591 | 609 | 667 | [
"DDInter393",
"DDInter1696"
] | Clarithromycin | Solifenacin | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Major | 2 | [
[
[
609,
25,
667
]
],
[
[
609,
6,
8374
],
[
8374,
45,
667
]
],
[
[
609,
21,
28743
],
[
28743,
60,
667
]
],
[
[
609,
62,
112
],
[
112,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Solifenacin"
]
],
[
[
"Clarithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Solifenacin (Compound)
Clarithromycin (Compound) causes Atrial fibrillation (Side Effect) and Atrial fibrillation (Side Effect) is caused by Solifenacin (Compound)
Clarithromycin may cause a minor interaction that can limit clinical effects whe... |
DB01036 | DB01619 | 211 | 830 | [
"DDInter1832",
"DDInter1441"
] | Tolterodine | Phenindamine | Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. Tolterodine acts on M2 and M3 subtypes of muscarinic receptors. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
211,
24,
830
]
],
[
[
211,
24,
537
],
[
537,
40,
830
]
],
[
[
211,
63,
1219
],
[
1219,
40,
830
]
],
[
[
211,
63,
13
],
[
13,
24,... | [
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Tolterodine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[... | Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Tolterodine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Compound... |
DB00313 | DB01041 | 556 | 770 | [
"DDInter1913",
"DDInter1789"
] | Valproic acid | Thalidomide | Valproic acid, or valproate, is an fatty acid derivative and anticonvulsant originally synthesized in 1881 by Beverly S. Burton. It enjoyed use as a popular organic solvent in industry and pharmaceutical manufacturing for nearly a century. In 1963, a serendipitous discovery was made by George Carraz during his investig... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
556,
24,
770
]
],
[
[
556,
6,
7524
],
[
7524,
45,
770
]
],
[
[
556,
21,
29177
],
[
29177,
60,
770
]
],
[
[
556,
24,
609
],
[
609,
... | [
[
[
"Valproic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Valproic acid",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Comp... | Valproic acid (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Thalidomide (Compound)
Valproic acid (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Thalidomide (Compound)
Valproic acid may cause a moderate interaction that could exacerbate d... |
DB00078 | DB00812 | 1,172 | 998 | [
"DDInter898",
"DDInter1451"
] | Ibritumomab tiuxetan | Phenylbutazone | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Major | 2 | [
[
[
1172,
25,
998
]
],
[
[
1172,
25,
804
],
[
804,
40,
998
]
],
[
[
1172,
25,
927
],
[
927,
63,
998
]
],
[
[
1172,
25,
1061
],
[
1061,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylbutazone"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfinpyrazone"
],
[
... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Sulfinpyrazone and Sulfinpyrazone (Compound) resembles Phenylbutazone (Compound)
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a moderate interaction that c... |
DB00241 | DB00488 | 288 | 196 | [
"DDInter257",
"DDInter57"
] | Butalbital | Altretamine | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects. | Moderate | 1 | [
[
[
288,
24,
196
]
],
[
[
288,
23,
752
],
[
752,
63,
196
]
],
[
[
288,
24,
597
],
[
597,
24,
196
]
],
[
[
288,
40,
1023
],
[
1023,
2... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Altretamine"
]
],
[
[
"Butalbital",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
],
[
... | Butalbital may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Altretamine
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Ch... |
DB00374 | DB00489 | 1,061 | 17 | [
"DDInter1852",
"DDInter1704"
] | Treprostinil | Sotalol | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
1061,
24,
17
]
],
[
[
1061,
63,
88
],
[
88,
40,
17
]
],
[
[
1061,
18,
3576
],
[
3576,
45,
17
]
],
[
[
1061,
21,
28719
],
[
28719,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],
[
... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Treprostinil (Compound) downregulates ADRB2 (Gene) and ADRB2 (Gene) is bound by Sotalol (Compound)
Treprostinil (Compound) causes Pain (Side Effect) and Pain (Si... |
DB00930 | DB11921 | 166 | 1,019 | [
"DDInter432",
"DDInter492"
] | Colesevelam | Deflazacort | Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in th... | Deflazacort, also known as Emflaza, is a corticosteroid prodrug used as an agent to manage Duchenne Muscular Dystrophy (DMD). It is marketed by Marathon Pharmaceuticals and was approved in February 2017 by the FDA.[L6694,FDA label] Duchenne Muscular Dystrophy is an inherited disorder resulting from mutations of the dys... | Moderate | 1 | [
[
[
166,
24,
1019
]
],
[
[
166,
24,
959
],
[
959,
24,
1019
]
],
[
[
166,
63,
629
],
[
629,
24,
1019
]
],
[
[
166,
24,
1220
],
[
1220,
... | [
[
[
"Colesevelam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deflazacort"
]
],
[
[
"Colesevelam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Deflazacort
Colesevelam may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Siroli... |
DB00348 | DB08865 | 254 | 1,593 | [
"DDInter1300",
"DDInter448"
] | Nitisinone | Crizotinib | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
254,
24,
1593
]
],
[
[
254,
21,
28771
],
[
28771,
60,
1593
]
],
[
[
254,
23,
307
],
[
307,
23,
1593
]
],
[
[
254,
24,
283
],
[
283,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Nitisinone",
"{u} (Compound) causes {v} (Side Effect)",
"Respiratory failure"
],
[
"Respiratory failure",
"{u} (... | Nitisinone (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Crizotinib (Compound)
Nitisinone may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when take... |
DB00393 | DB12267 | 854 | 1,476 | [
"DDInter1295",
"DDInter233"
] | Nimodipine | Brigatinib | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
854,
24,
1476
]
],
[
[
854,
24,
629
],
[
629,
24,
1476
]
],
[
[
854,
63,
1184
],
[
1184,
24,
1476
]
],
[
[
854,
1,
376
],
[
376,
... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Nimodipine may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra m... |
DB00445 | DB01238 | 322 | 673 | [
"DDInter655",
"DDInter118"
] | Epirubicin | Aripiprazole | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
322,
24,
673
]
],
[
[
322,
24,
851
],
[
851,
1,
673
]
],
[
[
322,
24,
827
],
[
827,
40,
673
]
],
[
[
322,
18,
5235
],
[
5235,
46... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],
[
... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound... |
DB00502 | DB12010 | 1,300 | 214 | [
"DDInter853",
"DDInter785"
] | Haloperidol | Fostamatinib | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1300,
24,
214
]
],
[
[
1300,
24,
723
],
[
723,
24,
214
]
],
[
[
1300,
25,
51
],
[
51,
24,
214
]
],
[
[
1300,
64,
322
],
[
322,
2... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
... | Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Haloperidol may lead to a major life threatening interaction when taken with Daunorubicin and Daunorubicin ma... |
DB01147 | DB01211 | 950 | 609 | [
"DDInter418",
"DDInter393"
] | Cloxacillin | Clarithromycin | A semi-synthetic penicillin antibiotic which is a chlorinated derivative of [oxacillin]. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Minor | 0 | [
[
[
950,
23,
609
]
],
[
[
950,
1,
319
],
[
319,
23,
609
]
],
[
[
950,
40,
339
],
[
339,
62,
609
]
],
[
[
950,
40,
916
],
[
916,
23,
... | [
[
[
"Cloxacillin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
]
],
[
[
"Cloxacillin",
"{u} (Compound) resembles {v} (Compound)",
"Amoxicillin"
],
[
"Amoxicillin",
"{u} may cause a m... | Cloxacillin (Compound) resembles Amoxicillin (Compound) and Amoxicillin may cause a minor interaction that can limit clinical effects when taken with Clarithromycin
Cloxacillin (Compound) resembles Bacampicillin (Compound) and Bacampicillin may cause a minor interaction that can limit clinical effects when taken with C... |
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