drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01166 | DB11110 | 477 | 603 | [
"DDInter379",
"DDInter1115"
] | Cilostazol | Magnesium citrate | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
477,
24,
603
]
],
[
[
477,
25,
57
],
[
57,
24,
603
]
],
[
[
477,
63,
789
],
[
789,
24,
603
]
],
[
[
477,
24,
9
],
[
9,
24,
... | [
[
[
"Cilostazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Cilostazol may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Foscarnet and Fos... |
DB00855 | DB01044 | 213 | 246 | [
"DDInter72",
"DDInter809"
] | Aminolevulinic acid | Gatifloxacin | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Major | 2 | [
[
[
213,
25,
246
]
],
[
[
213,
64,
1176
],
[
1176,
1,
246
]
],
[
[
213,
25,
872
],
[
872,
40,
246
]
],
[
[
213,
7,
2592
],
[
2592,
4... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gatifloxacin"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Moxifloxacin"
],
[
"Mox... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Gatifloxacin (Compound)
Aminolevulinic acid may lead to a major life threatening interaction when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Gatifloxacin (Compound)
... |
DB01069 | DB06701 | 401 | 1,177 | [
"DDInter1533",
"DDInter521"
] | Promethazine | Dexmethylphenidate | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer s... | Moderate | 1 | [
[
[
401,
24,
1177
]
],
[
[
401,
63,
895
],
[
895,
1,
1177
]
],
[
[
401,
63,
19
],
[
19,
40,
1177
]
],
[
[
401,
6,
12523
],
[
12523,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexmethylphenidate"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylphenidate... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Methylphenidate and Methylphenidate (Compound) resembles Dexmethylphenidate (Compound)
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resemble... |
DB00450 | DB08875 | 78 | 1,618 | [
"DDInter603",
"DDInter262"
] | Droperidol | Cabozantinib | A butyrophenone with general properties similar to those of haloperidol. It is used in conjunction with an opioid analgesic such as fentanyl to maintain the patient in a calm state of neuroleptanalgesia with indifference to surroundings but still able to cooperate with the surgeon. It is also used as a premedicant, as ... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
78,
25,
1618
]
],
[
[
78,
23,
112
],
[
112,
23,
1618
]
],
[
[
78,
24,
384
],
[
384,
63,
1618
]
],
[
[
78,
25,
1662
],
[
1662,
63... | [
[
[
"Droperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Droperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metroni... | Droperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Droperidol may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Id... |
DB00308 | DB00836 | 347 | 543 | [
"DDInter901",
"DDInter1088"
] | Ibutilide | Loperamide | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
347,
24,
543
]
],
[
[
347,
25,
888
],
[
888,
24,
543
]
],
[
[
347,
21,
28722
],
[
28722,
60,
543
]
],
[
[
347,
25,
982
],
[
982,
... | [
[
[
"Ibutilide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
],
[
"Tamoxifen",
... | Ibutilide may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Loperamide
Ibutilide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Loperamide (Compound)
Ibutilide may lead to... |
DB00196 | DB00834 | 600 | 932 | [
"DDInter743",
"DDInter1215"
] | Fluconazole | Mifepristone | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Mifepristone is a progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercor... | Major | 2 | [
[
[
600,
25,
932
]
],
[
[
600,
6,
7524
],
[
7524,
45,
932
]
],
[
[
600,
21,
29152
],
[
29152,
60,
932
]
],
[
[
600,
23,
1101
],
[
1101,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mifepristone"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Mif... | Fluconazole (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Mifepristone (Compound)
Fluconazole (Compound) causes Thirst (Side Effect) and Thirst (Side Effect) is caused by Mifepristone (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexar... |
DB00041 | DB00881 | 1,648 | 954 | [
"DDInter38",
"DDInter1554"
] | Aldesleukin | Quinapril | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
1648,
24,
954
]
],
[
[
1648,
24,
1638
],
[
1638,
1,
954
]
],
[
[
1648,
24,
1523
],
[
1523,
40,
954
]
],
[
[
1648,
24,
251
],
[
251,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
[... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Quinapril (Compound... |
DB00414 | DB01050 | 590 | 848 | [
"DDInter16",
"DDInter900"
] | Acetohexamide | Ibuprofen | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Moderate | 1 | [
[
[
590,
24,
848
]
],
[
[
590,
24,
752
],
[
752,
23,
848
]
],
[
[
590,
63,
362
],
[
362,
23,
848
]
],
[
[
590,
24,
286
],
[
286,
62,... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ibuprofen
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phen... |
DB00465 | DB09472 | 886 | 1,383 | [
"DDInter1010",
"DDInter1693"
] | Ketorolac | Sodium sulfate | Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution. It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, men... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
886,
24,
1383
]
],
[
[
886,
24,
1613
],
[
1613,
24,
1383
]
],
[
[
886,
25,
1618
],
[
1618,
24,
1383
]
],
[
[
886,
63,
912
],
[
912,
... | [
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Ketorolac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
... | Ketorolac may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a and Peginterferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Ketorolac may lead to a major life threatening interaction when taken with Cabozantinib... |
DB00317 | DB01211 | 883 | 609 | [
"DDInter810",
"DDInter393"
] | Gefitinib | Clarithromycin | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
883,
24,
609
]
],
[
[
883,
6,
4973
],
[
4973,
45,
609
]
],
[
[
883,
7,
5409
],
[
5409,
46,
609
]
],
[
[
883,
18,
4360
],
[
4360,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Gefitinib",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Gefitinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Clarithromycin (Compound)
Gefitinib (Compound) upregulates SOCS2 (Gene) and SOCS2 (Gene) is upregulated by Clarithromycin (Compound)
Gefitinib (Compound) downregulates TIMM9 (Gene) and TIMM9 (Gene) is downregulated by Clarithromycin (Compound)
Gefitin... |
DB01050 | DB01362 | 848 | 497 | [
"DDInter900",
"DDInter960"
] | Ibuprofen | Iohexol | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
848,
25,
497
]
],
[
[
848,
25,
258
],
[
258,
40,
497
]
],
[
[
848,
21,
28681
],
[
28681,
60,
497
]
],
[
[
848,
63,
323
],
[
323,
... | [
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Ibuprofen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
],
[
"Iodixanol",
"{u} (Compoun... | Ibuprofen may lead to a major life threatening interaction when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Ibuprofen (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Ibuprofen may cause a moderate interaction that could e... |
DB00502 | DB00927 | 1,300 | 1,559 | [
"DDInter853",
"DDInter712"
] | Haloperidol | Famotidine | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
1300,
24,
1559
]
],
[
[
1300,
6,
10215
],
[
10215,
45,
1559
]
],
[
[
1300,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
1300,
24,
286
],
[
... | [
[
[
"Haloperidol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Haloperidol",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compoun... | Haloperidol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Famotidine (Compound)
Haloperidol (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Haloperidol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydrox... |
DB00981 | DB11732 | 1,528 | 1,097 | [
"DDInter1462",
"DDInter1027"
] | Physostigmine | Lasmiditan | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Moderate | 1 | [
[
[
1528,
24,
1097
]
],
[
[
1528,
63,
701
],
[
701,
24,
1097
]
],
[
[
1528,
24,
272
],
[
272,
24,
1097
]
],
[
[
1528,
25,
593
],
[
593,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lasmiditan"
]
],
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramin... |
DB00604 | DB08871 | 1,425 | 36 | [
"DDInter385",
"DDInter666"
] | Cisapride | Eribulin | In many countries (including Canada) cisapride has been either withdrawn or has had its indications limited due to reports about long QT syndrome due to cisapride, which predisposes to arrhythmias. The FDA issued a warning letter regarding this risk to health care professionals and patients. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1425,
25,
36
]
],
[
[
1425,
25,
122
],
[
122,
23,
36
]
],
[
[
1425,
23,
1247
],
[
1247,
23,
36
]
],
[
[
1425,
25,
519
],
[
519,
... | [
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Cisapride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Verapamil"
],
[
"Verapamil",
"{u} may cau... | Cisapride may lead to a major life threatening interaction when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Cisapride may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may caus... |
DB00586 | DB09054 | 1,512 | 384 | [
"DDInter537",
"DDInter905"
] | Diclofenac | Idelalisib | Diclofenac is a phenylacetic acid derivative and non-steroidal anti-inflammatory drug (NSAID).[label] NSAIDs inhibit cyclooxygenase (COX)-1 and-2 which are the enzyme responsible for producing prostaglandins (PGs). PGs contribute to inflammation and pain signalling. Diclofenac, like other NSAIDs, is often used as first... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1512,
24,
384
]
],
[
[
1512,
24,
222
],
[
222,
23,
384
]
],
[
[
1512,
63,
1230
],
[
1230,
23,
384
]
],
[
[
1512,
24,
1627
],
[
1627,
... | [
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Diclofenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalo... |
DB00278 | DB12500 | 291 | 283 | [
"DDInter117",
"DDInter714"
] | Argatroban | Fedratinib | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
291,
25,
283
]
],
[
[
291,
24,
885
],
[
885,
24,
283
]
],
[
[
291,
25,
932
],
[
932,
24,
283
]
],
[
[
291,
63,
529
],
[
529,
24,... | [
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
"Epoprost... | Argatroban may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Argatroban may lead to a major life threatening interaction when taken with Mifepristone and Mifepristone ma... |
DB09330 | DB12015 | 985 | 1,033 | [
"DDInter1352",
"DDInter53"
] | Osimertinib | Alpelisib | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
985,
24,
1033
]
],
[
[
985,
63,
154
],
[
154,
24,
1033
]
],
[
[
985,
64,
576
],
[
576,
24,
1033
]
],
[
[
985,
24,
738
],
[
738,
... | [
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
],
[
... | Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone and Lurasidone may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Osimertinib may lead to a major life threatening interaction when taken with Methadone and Methadone may cause a... |
DB01030 | DB05015 | 869 | 1,077 | [
"DDInter1835",
"DDInter174"
] | Topotecan | Belinostat | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Moderate | 1 | [
[
[
869,
24,
1077
]
],
[
[
869,
63,
1253
],
[
1253,
24,
1077
]
],
[
[
869,
24,
1136
],
[
1136,
63,
1077
]
],
[
[
869,
24,
4
],
[
4,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belinostat"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palifermin"
],
[
... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Palifermin and Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Belinostat
Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Denosumab and Denosumab... |
DB01200 | DB11130 | 469 | 407 | [
"DDInter243",
"DDInter1344"
] | Bromocriptine | Opium | Bromocriptine mesylate is a semisynthetic ergot alkaloid derivative with potent dopaminergic activity. It inhibits prolactin secretion and may be used to treat dysfunctions associated with hyperprolactinemia. Bromocriptine is also indicated for the management of signs and symptoms of Parkinsonian Syndrome, as well as t... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
469,
24,
407
]
],
[
[
469,
63,
662
],
[
662,
24,
407
]
],
[
[
469,
24,
849
],
[
849,
24,
407
]
],
[
[
469,
24,
1609
],
[
1609,
6... | [
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Bromocriptine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Bromocriptine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and... |
DB00852 | DB09038 | 1,445 | 1,450 | [
"DDInter1545",
"DDInter636"
] | Pseudoephedrine | Empagliflozin | Pseudoephedrine is structurally related to [ephedrine] but exerts a weaker effect on the sympathetic nervous system.[A188820,A188823] Both drugs naturally occur in in ephedra plant which have a history of use in traditional Eastern medicine and were first researched in the west in 1889. The decongestant effect of pseud... | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
1445,
24,
1450
]
],
[
[
1445,
63,
461
],
[
461,
24,
1450
]
],
[
[
1445,
24,
659
],
[
659,
63,
1450
]
],
[
[
1445,
24,
1551
],
[
1551,
... | [
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Pseudoephedrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
]... | Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Pseudoephedrine may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and... |
DB08932 | DB12332 | 1,398 | 1,619 | [
"DDInter1111",
"DDInter1626"
] | Macitentan | Rucaparib | Macitentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension. It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] due to its lower risk of hepatotoxicity. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1398,
24,
1619
]
],
[
[
1398,
63,
1419
],
[
1419,
24,
1619
]
],
[
[
1398,
24,
159
],
[
159,
63,
1619
]
],
[
[
1398,
25,
913
],
[
913,
... | [
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Macitentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrec... |
DB00682 | DB01015 | 126 | 1,247 | [
"DDInter1951",
"DDInter1724"
] | Warfarin | Sulfamethoxazole | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Major | 2 | [
[
[
126,
25,
1247
]
],
[
[
126,
64,
1029
],
[
1029,
1,
1247
]
],
[
[
126,
25,
698
],
[
698,
1,
1247
]
],
[
[
126,
6,
3486
],
[
3486,
... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfamethoxazole"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sulfisoxazole"
],
[
"Sulfisoxazole",
... | Warfarin may lead to a major life threatening interaction when taken with Sulfisoxazole and Sulfisoxazole (Compound) resembles Sulfamethoxazole (Compound)
Warfarin may lead to a major life threatening interaction when taken with Sulfadoxine and Sulfadoxine (Compound) resembles Sulfamethoxazole (Compound)
Warfarin (Comp... |
DB01234 | DB14783 | 1,220 | 287 | [
"DDInter513",
"DDInter574"
] | Dexamethasone | Diroximel fumarate | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1220,
24,
287
]
],
[
[
1220,
63,
1101
],
[
1101,
24,
287
]
],
[
[
1220,
24,
384
],
[
384,
24,
287
]
],
[
[
1220,
40,
870
],
[
870,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Idelali... |
DB00284 | DB00627 | 1,647 | 265 | [
"DDInter11",
"DDInter1286"
] | Acarbose | Niacin | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Moderate | 1 | [
[
[
1647,
24,
265
]
],
[
[
1647,
21,
29519
],
[
29519,
60,
265
]
],
[
[
1647,
63,
1560
],
[
1560,
24,
265
]
],
[
[
1647,
24,
322
],
[
322,... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niacin"
]
],
[
[
"Acarbose",
"{u} (Compound) causes {v} (Side Effect)",
"Gastrointestinal symptom NOS"
],
[
"Gastrointestinal symptom NOS",
... | Acarbose (Compound) causes Gastrointestinal symptom NOS (Side Effect) and Gastrointestinal symptom NOS (Side Effect) is caused by Niacin (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbat... |
DB00421 | DB01075 | 443 | 1,376 | [
"DDInter1707",
"DDInter569"
] | Spironolactone | Diphenhydramine | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Moderate | 1 | [
[
[
443,
24,
1376
]
],
[
[
443,
24,
401
],
[
401,
24,
1376
]
],
[
[
443,
23,
126
],
[
126,
1,
1376
]
],
[
[
443,
21,
28921
],
[
28921,
... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
]
],
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
... | Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine
Spironolactone may cause a minor interaction that can limit clinical effects when taken with Warfar... |
DB00215 | DB01041 | 1,230 | 770 | [
"DDInter388",
"DDInter1789"
] | Citalopram | Thalidomide | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1230,
24,
770
]
],
[
[
1230,
6,
6365
],
[
6365,
45,
770
]
],
[
[
1230,
21,
29425
],
[
29425,
60,
770
]
],
[
[
1230,
25,
609
],
[
609,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Citalopram",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)"... | Citalopram (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Citalopram (Compound) causes Myocardial ischaemia (Side Effect) and Myocardial ischaemia (Side Effect) is caused by Thalidomide (Compound)
Citalopram may lead to a major life threatening interaction when taken with Clarithrom... |
DB08901 | DB09054 | 1,468 | 384 | [
"DDInter1492",
"DDInter905"
] | Ponatinib | Idelalisib | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1468,
24,
384
]
],
[
[
1468,
63,
222
],
[
222,
23,
384
]
],
[
[
1468,
24,
1627
],
[
1627,
62,
384
]
],
[
[
1468,
24,
555
],
[
555,
... | [
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Ponatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabi... |
DB00348 | DB00414 | 254 | 590 | [
"DDInter1300",
"DDInter16"
] | Nitisinone | Acetohexamide | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
254,
24,
590
]
],
[
[
254,
24,
1017
],
[
1017,
63,
590
]
],
[
[
254,
63,
362
],
[
362,
24,
590
]
],
[
[
254,
24,
1622
],
[
1622,
... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[... | Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Acetohexamide
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phen... |
DB06081 | DB08901 | 1,046 | 1,468 | [
"DDInter286",
"DDInter1492"
] | Caplacizumab | Ponatinib | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
1046,
25,
1468
]
],
[
[
1046,
63,
1230
],
[
1230,
24,
1468
]
],
[
[
1046,
25,
1598
],
[
1598,
63,
1468
]
],
[
[
1046,
24,
637
],
[
637... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Caplacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
"Citalop... | Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Caplacizumab may lead to a major life threatening interaction when taken with Tazemetostat and Tazemetostat may... |
DB01267 | DB05812 | 519 | 1,374 | [
"DDInter1381",
"DDInter8"
] | Paliperidone | Abiraterone | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
519,
24,
1374
]
],
[
[
519,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
519,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
519,
62,
112
],
[
112,... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Paliperidone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compou... | Paliperidone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Paliperidone (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Paliperidone may cause a minor interaction that can limit clinical effects when taken with Metronidazole... |
DB01210 | DB09082 | 668 | 659 | [
"DDInter1050",
"DDInter1934"
] | Levobunolol (ophthalmic) | Vilanterol | Levobunolol is a cyclic ketone that is 3,4-dihydronaphthalen-1-one substituted at position 5 by a 3-(tert-butylamino)-2-hydroxypropoxy group (the S-enantiomer). A non-selective beta-adrenergic antagonist used (as its hydrochloride salt) for treatment of glaucoma. It has a role as an antiglaucoma drug and a beta-adrener... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Major | 2 | [
[
[
668,
25,
659
]
],
[
[
668,
64,
1674
],
[
1674,
24,
659
]
],
[
[
668,
63,
1636
],
[
1636,
24,
659
]
],
[
[
668,
25,
144
],
[
144,
... | [
[
[
"Levobunolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vilanterol"
]
],
[
[
"Levobunolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Orciprenaline"
],
[
"Orciprenaline",
... | Levobunolol may lead to a major life threatening interaction when taken with Vilanterol
Levobunolol may lead to a major life threatening interaction when taken with Orciprenaline and Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Levobunolol may cause a moderate... |
DB00738 | DB01250 | 485 | 712 | [
"DDInter1420",
"DDInter1334"
] | Pentamidine | Olsalazine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Moderate | 1 | [
[
[
485,
24,
712
]
],
[
[
485,
24,
50
],
[
50,
40,
712
]
],
[
[
485,
63,
1199
],
[
1199,
24,
712
]
],
[
[
485,
24,
473
],
[
473,
24,... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
],
... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine (Compound) resembles Olsalazine (Compound)
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Ibandronate and Ibandronate may cause a moderate interaction ... |
DB09293 | DB11071 | 116 | 1,004 | [
"DDInter954",
"DDInter1449"
] | Iodide I-131 | Phenyl salicylate | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
116,
24,
1004
]
],
[
[
116,
63,
500
],
[
500,
24,
1004
]
],
[
[
116,
24,
235
],
[
235,
63,
1004
]
],
[
[
116,
63,
500
],
[
500,
... | [
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxaparin"
... | Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Desirudin ... |
DB00280 | DB09078 | 494 | 1,228 | [
"DDInter575",
"DDInter1036"
] | Disopyramide | Lenvatinib | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
494,
25,
1228
]
],
[
[
494,
23,
112
],
[
112,
23,
1228
]
],
[
[
494,
25,
609
],
[
609,
24,
1228
]
],
[
[
494,
24,
770
],
[
770,
... | [
[
[
"Disopyramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Disopyramide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Disopyramide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Disopyramide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromy... |
DB00398 | DB09118 | 79 | 1,580 | [
"DDInter1702",
"DDInter1711"
] | Sorafenib | Stiripentol | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
79,
24,
1580
]
],
[
[
79,
24,
1409
],
[
1409,
24,
1580
]
],
[
[
79,
25,
478
],
[
478,
24,
1580
]
],
[
[
79,
63,
1324
],
[
1324,
... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Sorafenib may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moder... |
DB00261 | DB14509 | 702 | 1,399 | [
"DDInter93",
"DDInter1081"
] | Anagrelide | Lithium carbonate | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
702,
25,
1399
]
],
[
[
702,
24,
1479
],
[
1479,
23,
1399
]
],
[
[
702,
25,
1374
],
[
1374,
24,
1399
]
],
[
[
702,
24,
144
],
[
144,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],
[
... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Anagrelide may lead to a major life threatening interaction when taken with Abiraterone... |
DB00512 | DB00781 | 91 | 1,481 | [
"DDInter1916",
"DDInter1489"
] | Vancomycin | Polymyxin B | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | Moderate | 1 | [
[
[
91,
24,
1481
]
],
[
[
91,
24,
1441
],
[
1441,
40,
1481
]
],
[
[
91,
21,
28719
],
[
28719,
60,
1481
]
],
[
[
91,
24,
50
],
[
50,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polymyxin B"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacitracin"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Bacitracin and Bacitracin (Compound) resembles Polymyxin B (Compound)
Vancomycin (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Polymyxin B (Compound)
Vancomycin may cause a moderate interaction that cou... |
DB00631 | DB15091 | 372 | 676 | [
"DDInter405",
"DDInter1901"
] | Clofarabine | Upadacitinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
372,
25,
676
]
],
[
[
372,
63,
1461
],
[
1461,
23,
676
]
],
[
[
372,
24,
1430
],
[
1430,
24,
676
]
],
[
[
372,
63,
600
],
[
600,
... | [
[
[
"Clofarabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipu... |
DB06616 | DB06636 | 594 | 1,623 | [
"DDInter224",
"DDInter980"
] | Bosutinib | Isavuconazonium | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Major | 2 | [
[
[
594,
25,
1623
]
],
[
[
594,
64,
1419
],
[
1419,
24,
1623
]
],
[
[
594,
63,
1557
],
[
1557,
24,
1623
]
],
[
[
594,
25,
1593
],
[
1593,
... | [
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Imatinib"
],
[
"Imatinib",
"{u} ma... | Bosutinib may lead to a major life threatening interaction when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Bosutinib may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may cause a... |
DB00295 | DB00363 | 475 | 695 | [
"DDInter1244",
"DDInter419"
] | Morphine | Clozapine | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
475,
25,
695
]
],
[
[
475,
25,
1178
],
[
1178,
1,
695
]
],
[
[
475,
25,
902
],
[
902,
40,
695
]
],
[
[
475,
24,
1219
],
[
1219,
... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trifluoperazine"
],
[
"Trifluoperazine",
"... | Morphine may lead to a major life threatening interaction when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Clozapine (Compound)
Morphine may lead to a major life threatening interaction when taken with Clobazam and Clobazam (Compound) resembles Clozapine (Compound)
Morphine may cause a moderate ... |
DB00687 | DB12825 | 870 | 1,375 | [
"DDInter747",
"DDInter1032"
] | Fludrocortisone | Lefamulin | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
870,
24,
1375
]
],
[
[
870,
24,
159
],
[
159,
63,
1375
]
],
[
[
870,
25,
976
],
[
976,
24,
1375
]
],
[
[
870,
63,
1101
],
[
1101,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
... | Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Fludrocortisone may lead to a major life threatening interaction when taken with Tofacitinib and Tofac... |
DB01261 | DB01404 | 170 | 757 | [
"DDInter1679",
"DDInter820"
] | Sitagliptin | Ginseng | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
170,
24,
757
]
],
[
[
170,
63,
245
],
[
245,
24,
757
]
],
[
[
170,
24,
1254
],
[
1254,
24,
757
]
],
[
[
170,
24,
1296
],
[
1296,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine an... |
DB00445 | DB14730 | 322 | 1,412 | [
"DDInter655",
"DDInter264"
] | Epirubicin | Calaspargase pegol | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
322,
24,
1412
]
],
[
[
322,
24,
250
],
[
250,
24,
1412
]
],
[
[
322,
63,
883
],
[
883,
24,
1412
]
],
[
[
322,
25,
868
],
[
868,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]... | Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab and Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib... |
DB00675 | DB08899 | 888 | 129 | [
"DDInter1744",
"DDInter649"
] | Tamoxifen | Enzalutamide | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
888,
24,
129
]
],
[
[
888,
24,
918
],
[
918,
1,
129
]
],
[
[
888,
6,
8374
],
[
8374,
45,
129
]
],
[
[
888,
21,
29377
],
[
29377,
... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Tamoxifen (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Tamoxifen (Compound) causes Musculoskeletal pain (Side Effec... |
DB01149 | DB01240 | 851 | 885 | [
"DDInter1274",
"DDInter657"
] | Nefazodone | Epoprostenol | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
851,
24,
885
]
],
[
[
851,
63,
1061
],
[
1061,
1,
885
]
],
[
[
851,
21,
28684
],
[
28684,
60,
885
]
],
[
[
851,
25,
283
],
[
283,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Nefazodone (Compound) causes Hypoaesthesia (Side Effect) and Hypoaesthesia (Side Effect) is caused by Epoprostenol (Compound)
Nefazodone may lead to a maj... |
DB00544 | DB10583 | 970 | 949 | [
"DDInter757",
"DDInter415"
] | Fluorouracil | Clostridium tetani toxoid antigen (formaldehyde inactivated) | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
970,
24,
949
]
],
[
[
970,
63,
589
],
[
589,
24,
949
]
],
[
[
970,
25,
1377
],
[
1377,
24,
949
]
],
[
[
970,
24,
663
],
[
663,
2... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases wh... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Fluorouracil may lead to a major life threatening interaction ... |
DB00757 | DB01218 | 1,166 | 1,493 | [
"DDInter581",
"DDInter852"
] | Dolasetron | Halofantrine | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
1166,
25,
1493
]
],
[
[
1166,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
1166,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
1166,
24,
479
],
[
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Dolasetron",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Halof... | Dolasetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Dolasetron (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Dolasetron may cause a moderate interaction that could exacerbate diseases when ta... |
DB00945 | DB01032 | 1,479 | 824 | [
"DDInter20",
"DDInter1522"
] | Acetylsalicylic acid | Probenecid | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. | Moderate | 1 | [
[
[
1479,
24,
824
]
],
[
[
1479,
24,
1411
],
[
1411,
63,
824
]
],
[
[
1479,
10,
11678
],
[
11678,
44,
824
]
],
[
[
1479,
6,
4973
],
[
4973... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probenecid"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbuta... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Probenecid
Acetylsalicylic acid (Compound) palliates gout (Disease) and gout (Disease) is treated by Probenecid... |
DB01254 | DB08893 | 1,213 | 271 | [
"DDInter484",
"DDInter1229"
] | Dasatinib | Mirabegron | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Minor | 0 | [
[
[
1213,
23,
271
]
],
[
[
1213,
63,
371
],
[
371,
40,
271
]
],
[
[
1213,
6,
4973
],
[
4973,
45,
271
]
],
[
[
1213,
21,
28956
],
[
28956,
... | [
[
[
"Dasatinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
]
],
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
],
[
... | Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) resembles Mirabegron (Compound)
Dasatinib (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Mirabegron (Compound)
Dasatinib (Compound) causes Palpitations (Side Effect) and Palpitati... |
DB00112 | DB00710 | 374 | 1,199 | [
"DDInter201",
"DDInter897"
] | Bevacizumab | Ibandronate | There is a great deal of evidence indicating that vascular endothelial growth factor (VEGF) is important for the survival and proliferation of cancer cells.[A192939,A192837,A192891,A193275] VEGF plays an important role in angiogenesis, lymphangiogenesis, and tumor growth, which are all factors that contribute to its at... | Ibandronate, or BM 21.0955, is a third generation, nitrogen containing bisphosphonate similar to [zoledronic acid], [minodronic acid], and [risedronic acid].[A203111,A203138] It is used to prevent and treat postmenopausal osteoporosis.[L13805,L13808] Ibandronate was first described in the literature in 1993 as a treatm... | Moderate | 1 | [
[
[
374,
24,
1199
]
],
[
[
374,
24,
1485
],
[
1485,
1,
1199
]
],
[
[
374,
24,
1008
],
[
1008,
40,
1199
]
],
[
[
374,
25,
770
],
[
770,
... | [
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibandronate"
]
],
[
[
"Bevacizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alendronic acid"
],
... | Bevacizumab may cause a moderate interaction that could exacerbate diseases when taken with Alendronic acid and Alendronic acid (Compound) resembles Ibandronate (Compound)
Bevacizumab may cause a moderate interaction that could exacerbate diseases when taken with Risedronic acid and Risedronic acid (Compound) resembles... |
DB00372 | DB00726 | 999 | 1,164 | [
"DDInter1793",
"DDInter1876"
] | Thiethylperazine | Trimipramine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Moderate | 1 | [
[
[
999,
24,
1164
]
],
[
[
999,
24,
1237
],
[
1237,
40,
1164
]
],
[
[
999,
25,
675
],
[
675,
40,
1164
]
],
[
[
999,
63,
576
],
[
576,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine (Compound) resembles Trimipramine (Compound)
Thiethylperazine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene (Compound) resembles Tri... |
DB00446 | DB01118 | 597 | 33 | [
"DDInter351",
"DDInter76"
] | Chloramphenicol | Amiodarone | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
597,
24,
33
]
],
[
[
597,
24,
540
],
[
540,
1,
33
]
],
[
[
597,
6,
3486
],
[
3486,
45,
33
]
],
[
[
597,
7,
3727
],
[
3727,
46,
... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Chloramphenicol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Amiodarone (Compound)
Chloramphenicol (Compound) upregulates MAL (Gene) and ... |
DB00092 | DB14762 | 58 | 994 | [
"DDInter40",
"DDInter1602"
] | Alefacept | Risankizumab | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Moderate | 1 | [
[
[
58,
24,
994
]
],
[
[
58,
23,
1114
],
[
1114,
23,
994
]
],
[
[
58,
24,
4
],
[
4,
24,
994
]
],
[
[
58,
24,
287
],
[
287,
63,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risankizumab"
]
],
[
[
"Alefacept",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
... | Alefacept may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Risankizumab
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesucci... |
DB01004 | DB06704 | 563 | 247 | [
"DDInter806",
"DDInter952"
] | Ganciclovir | Iobenguane (I-131) | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
563,
24,
247
]
],
[
[
563,
21,
28787
],
[
28787,
60,
247
]
],
[
[
563,
1,
248
],
[
248,
24,
247
]
],
[
[
563,
24,
810
],
[
810,
... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iobenguane"
]
],
[
[
"Ganciclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is ... | Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane
Ganciclovir (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iobenguane (Compound)
Ganciclovir (Compound) resembles Valganciclovir (Compound) and Valganciclovir may cause a moderate... |
DB06616 | DB08864 | 594 | 786 | [
"DDInter224",
"DDInter1595"
] | Bosutinib | Rilpivirine | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
594,
24,
786
]
],
[
[
594,
64,
655
],
[
655,
1,
786
]
],
[
[
594,
6,
8374
],
[
8374,
45,
786
]
],
[
[
594,
21,
29343
],
[
29343,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etravirine"
],
[
"Etravirine"... | Bosutinib may lead to a major life threatening interaction when taken with Etravirine and Etravirine (Compound) resembles Rilpivirine (Compound)
Bosutinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Bosutinib (Compound) causes Blood creatinine increased (Side Effect) and Blood cr... |
DB00366 | DB09241 | 1,594 | 1,629 | [
"DDInter600",
"DDInter1186"
] | Doxylamine | Methylene blue | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
1594,
25,
1629
]
],
[
[
1594,
24,
697
],
[
697,
24,
1629
]
],
[
[
1594,
63,
1023
],
[
1023,
24,
1629
]
],
[
[
1594,
24,
851
],
[
851,
... | [
[
[
"Doxylamine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
"Phe... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbit... |
DB01259 | DB08886 | 392 | 637 | [
"DDInter1024",
"DDInter126"
] | Lapatinib | Asparaginase Erwinia chrysanthemi | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
392,
24,
637
]
],
[
[
392,
63,
167
],
[
167,
24,
637
]
],
[
[
392,
24,
72
],
[
72,
24,
637
]
],
[
[
392,
25,
1421
],
[
1421,
63,... | [
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Lapatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroc... | Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Lapatinib may cause a moderate interaction that could exacerbate diseases when tak... |
DB00860 | DB11124 | 891 | 209 | [
"DDInter1513",
"DDInter1560"
] | Prednisolone | Racepinephrine | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Minor | 0 | [
[
[
891,
23,
209
]
],
[
[
891,
40,
1573
],
[
1573,
23,
209
]
],
[
[
891,
1,
1351
],
[
1351,
23,
209
]
],
[
[
891,
23,
688
],
[
688,
... | [
[
[
"Prednisolone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Racepinephrine"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Prednisone"
],
[
"Prednisone",
"{u} may cause a m... | Prednisolone (Compound) resembles Prednisone (Compound) and Prednisone may cause a minor interaction that can limit clinical effects when taken with Racepinephrine
Prednisolone (Compound) resembles Flunisolide (Compound) and Flunisolide may cause a minor interaction that can limit clinical effects when taken with Racep... |
DB01394 | DB12130 | 1,554 | 1,017 | [
"DDInter431",
"DDInter1094"
] | Colchicine | Lorlatinib | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1554,
24,
1017
]
],
[
[
1554,
64,
14
],
[
14,
24,
1017
]
],
[
[
1554,
25,
1491
],
[
1491,
24,
1017
]
],
[
[
1554,
63,
134
],
[
134,
... | [
[
[
"Colchicine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Colchicine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rosuvastatin"
],
[
"Rosuvast... | Colchicine may lead to a major life threatening interaction when taken with Rosuvastatin and Rosuvastatin may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib
Colchicine may lead to a major life threatening interaction when taken with Midostaurin and Midostaurin may cause a moderat... |
DB00226 | DB06764 | 1,000 | 1,090 | [
"DDInter845",
"DDInter1787"
] | Guanadrel | Tetryzoline (nasal) | Guanadrel is an antihypertensive agent and postganglionic adrenergic blocking agent. | Tetryzoline is a member of imidazolines and a carboxamidine. It has a role as a sympathomimetic agent and a nasal decongestant. It is a conjugate base of a tetryzoline(1+). | Moderate | 1 | [
[
[
1000,
24,
1090
]
],
[
[
1000,
24,
1148
],
[
1148,
24,
1090
]
],
[
[
1000,
37,
247
],
[
247,
25,
1090
]
],
[
[
1000,
24,
1629
],
[
1629... | [
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetryzoline"
]
],
[
[
"Guanadrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Guanadrel may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Tetryzoline
Guanad... |
DB00968 | DB01124 | 1,551 | 1,411 | [
"DDInter1185",
"DDInter1828"
] | Methyldopa | Tolbutamide | Methyldopa, or α-methyldopa, is a centrally acting sympatholytic agent and an antihypertensive agent. It is an analog of DOPA (3,4‐hydroxyphenylanine), and it is a prodrug, meaning that the drug requires biotransformation to an active metabolite for therapeutic effects. Methyldopa works by binding to alpha(α)-2 adrener... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Minor | 0 | [
[
[
1551,
23,
1411
]
],
[
[
1551,
23,
959
],
[
959,
40,
1411
]
],
[
[
1551,
62,
245
],
[
245,
40,
1411
]
],
[
[
1551,
6,
4610
],
[
4610,
... | [
[
[
"Methyldopa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Tolbutamide"
]
],
[
[
"Methyldopa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Glipizide"
],
[
... | Methyldopa may cause a minor interaction that can limit clinical effects when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Methyldopa may cause a minor interaction that can limit clinical effects when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
Me... |
DB01105 | DB06081 | 222 | 1,046 | [
"DDInter1665",
"DDInter286"
] | Sibutramine | Caplacizumab | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Moderate | 1 | [
[
[
222,
24,
1046
]
],
[
[
222,
25,
1039
],
[
1039,
24,
1046
]
],
[
[
222,
63,
1171
],
[
1171,
24,
1046
]
],
[
[
222,
24,
885
],
[
885,
... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caplacizumab"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexfenfluramine"
],
[
"D... | Sibutramine may lead to a major life threatening interaction when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Caplacizumab
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Meloxicam and Meloxica... |
DB00987 | DB01208 | 1,224 | 945 | [
"DDInter460",
"DDInter1705"
] | Cytarabine | Sparfloxacin | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Sparfloxacin is a fluoroquinolone antibiotic indicated for bacterial infections. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. | Minor | 0 | [
[
[
1224,
23,
945
]
],
[
[
1224,
62,
739
],
[
739,
1,
945
]
],
[
[
1224,
23,
1539
],
[
1539,
1,
945
]
],
[
[
1224,
18,
3199
],
[
3199,
... | [
[
[
"Cytarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sparfloxacin"
]
],
[
[
"Cytarabine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lomefloxacin"
],
[
... | Cytarabine may cause a minor interaction that can limit clinical effects when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Sparfloxacin (Compound)
Cytarabine may cause a minor interaction that can limit clinical effects when taken with Ofloxacin and Ofloxacin (Compound) resembles Sparfloxacin (Compound... |
DB09268 | DB11986 | 1,662 | 484 | [
"DDInter1464",
"DDInter648"
] | Picosulfuric acid | Entrectinib | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1662,
24,
484
]
],
[
[
1662,
63,
1247
],
[
1247,
23,
484
]
],
[
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774
],
[
774,
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484
]
],
[
[
1662,
24,
180
],
[
180,
... | [
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxa... | Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00514 | DB00780 | 506 | 551 | [
"DDInter527",
"DDInter1440"
] | Dextromethorphan | Phenelzine | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Major | 2 | [
[
[
506,
25,
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]
],
[
[
506,
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],
[
1161,
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551
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[
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506,
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],
[
633,
40,
551
]
],
[
[
506,
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],
[
73,
25,... | [
[
[
"Dextromethorphan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
]
],
[
[
"Dextromethorphan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Selegiline"
],
[
"Selegiline",
... | Dextromethorphan may lead to a major life threatening interaction when taken with Selegiline and Selegiline (Compound) resembles Phenelzine (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Lisdexamfetamine and Lisdexamfetamine (Compound) resembles Phenelzine (C... |
DB08820 | DB15233 | 1,478 | 1,650 | [
"DDInter997",
"DDInter142"
] | Ivacaftor | Avapritinib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
1478,
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],
[
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63,
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[
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[
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1478,
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],
[
159,
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],
[
[
1478,
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1512
],
[
1512... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[
... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and La... |
DB00726 | DB09039 | 1,164 | 1,670 | [
"DDInter1876",
"DDInter629"
] | Trimipramine | Eliglustat | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
1164,
24,
1670
]
],
[
[
1164,
63,
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],
[
121,
24,
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[
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1164,
24,
272
],
[
272,
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]
],
[
[
1164,
25,
478
],
[
478,
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
... | Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Trimipramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniram... |
DB00005 | DB00330 | 1,057 | 238 | [
"DDInter687",
"DDInter689"
] | Etanercept | Ethambutol | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Moderate | 1 | [
[
[
1057,
24,
238
]
],
[
[
1057,
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458
],
[
458,
63,
238
]
],
[
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24,
1451
],
[
1451,
24,
238
]
],
[
[
1057,
25,
770
],
[
770,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethambutol"
]
],
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
],
[
... | Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Tinidazole and Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol
Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Interferon alfa-n1 an... |
DB00656 | DB00889 | 827 | 1,133 | [
"DDInter1851",
"DDInter840"
] | Trazodone | Granisetron | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Major | 2 | [
[
[
827,
25,
1133
]
],
[
[
827,
6,
8374
],
[
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[
[
827,
21,
29282
],
[
29282,
60,
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]
],
[
[
827,
23,
112
],
[
112,
... | [
[
[
"Trazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Granisetron"
]
],
[
[
"Trazodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Graniset... | Trazodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Granisetron (Compound)
Trazodone (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Granisetron (Compound)
Trazodone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Me... |
DB01148 | DB01176 | 1,128 | 537 | [
"DDInter738",
"DDInter453"
] | Flavoxate | Cyclizine | A drug that has been used in various urinary syndromes and as an antispasmodic. Its therapeutic usefulness and its mechanism of action are not clear. It may have local anesthetic activity and direct relaxing effects on smooth muscle as well as some activity as a muscarinic antagonist. [PubChem] | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1128,
24,
537
]
],
[
[
1128,
24,
1511
],
[
1511,
63,
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[
[
1128,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1128,
1,
11268
],
[
11268... | [
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Flavoxate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Flavoxate may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetiriz... |
DB00514 | DB14509 | 506 | 1,399 | [
"DDInter527",
"DDInter1081"
] | Dextromethorphan | Lithium carbonate | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
506,
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]
],
[
[
506,
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],
[
1374,
24,
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[
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475
],
[
475,
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],
[
[
506,
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1133
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[
1133,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abirater... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00011 | DB01362 | 1,451 | 497 | [
"DDInter944",
"DDInter960"
] | Interferon alfa-n1 | Iohexol | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1451,
25,
497
]
],
[
[
1451,
24,
242
],
[
242,
63,
497
]
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[
[
1451,
24,
33
],
[
33,
24,
497
]
],
[
[
1451,
24,
1267
],
[
1267,
... | [
[
[
"Interferon alfa-n1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Remdesivir"
],
[
... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Iohexol
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Amiodaro... |
DB01320 | DB06589 | 651 | 1,250 | [
"DDInter783",
"DDInter1400"
] | Fosphenytoin | Pazopanib | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
651,
24,
1250
]
],
[
[
651,
6,
3486
],
[
3486,
45,
1250
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],
[
[
651,
21,
28658
],
[
28658,
60,
1250
]
],
[
[
651,
40,
307
],
[
307,
... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Fosphenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Fosphenytoin (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Pazopanib (Compound)
Fosphenytoin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Pazopanib (Compound)
Fosphenytoin (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can li... |
DB00357 | DB05239 | 1,051 | 866 | [
"DDInter71",
"DDInter425"
] | Aminoglutethimide | Cobimetinib | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
1051,
24,
866
]
],
[
[
1051,
24,
214
],
[
214,
63,
866
]
],
[
[
1051,
24,
888
],
[
888,
24,
866
]
],
[
[
1051,
62,
1101
],
[
1101,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib... | Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with Ta... |
DB01254 | DB09280 | 1,213 | 1,604 | [
"DDInter484",
"DDInter1101"
] | Dasatinib | Lumacaftor | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Lumacaftor is a drug used in combination with as the fixed dose combination product Orkambi for the management of Cystic Fibrosis (CF) in patients aged 6 years and older. Cystic Fibrosis is an autosomal recessive disorder caused by one of several different mutations in the gene for the Cystic Fibrosis Transmembrane Con... | Major | 2 | [
[
[
1213,
25,
1604
]
],
[
[
1213,
64,
1171
],
[
1171,
24,
1604
]
],
[
[
1213,
63,
628
],
[
628,
24,
1604
]
],
[
[
1213,
25,
292
],
[
292,
... | [
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lumacaftor"
]
],
[
[
"Dasatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Meloxicam"
],
[
"Meloxicam",
"{u} may c... | Dasatinib may lead to a major life threatening interaction when taken with Meloxicam and Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Lumacaftor
Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Ergometrine and Ergometrine may cause a ... |
DB00582 | DB00992 | 1,622 | 842 | [
"DDInter1946",
"DDInter1182"
] | Voriconazole | Methyl aminolevulinate (topical) | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
1622,
24,
842
]
],
[
[
1622,
21,
29430
],
[
29430,
60,
842
]
],
[
[
1622,
24,
1274
],
[
1274,
24,
842
]
],
[
[
1622,
24,
820
],
[
820,... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Voriconazole",
"{u} (Compound) causes {v} (Side Effect)",
"Keratitis"
],
[
"Keratitis",
"{u} (Side... | Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Voriconazole (Compound) causes Keratitis (Side Effect) and Keratitis (Side Effect) is caused by Methyl aminolevulinate (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseas... |
DB00820 | DB14568 | 402 | 982 | [
"DDInter1736",
"DDInter1000"
] | Tadalafil | Ivosidenib | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
402,
24,
982
]
],
[
[
402,
63,
1101
],
[
1101,
23,
982
]
],
[
[
402,
24,
1478
],
[
1478,
24,
982
]
],
[
[
402,
24,
159
],
[
159,
... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor m... |
DB00285 | DB11110 | 1,100 | 603 | [
"DDInter1927",
"DDInter1115"
] | Venlafaxine | Magnesium citrate | Venlafaxine is an antidepressant and a serotonin and norepinephrine reuptake inhibitor (SNRI). Its active metabolite, [desvenlafaxine], works by blocking the reuptake of serotonin and norepinephrine, which are key neurotransmitters in mood regulation. Venlafaxine is officially approved to treat major depressive disorde... | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
1100,
24,
603
]
],
[
[
1100,
25,
57
],
[
57,
24,
603
]
],
[
[
1100,
24,
1616
],
[
1616,
24,
603
]
],
[
[
1100,
24,
484
],
[
484,
... | [
[
[
"Venlafaxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Venlafaxine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
],
[
... | Venlafaxine may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Venlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Histrelin and H... |
DB00059 | DB00951 | 1,560 | 1,072 | [
"DDInter1404",
"DDInter986"
] | Pegaspargase | Isoniazid | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
1560,
24,
1072
]
],
[
[
1560,
24,
1486
],
[
1486,
62,
1072
]
],
[
[
1560,
24,
175
],
[
175,
23,
1072
]
],
[
[
1560,
24,
1130
],
[
1130... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Isoniazid
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Tria... |
DB00909 | DB11730 | 306 | 351 | [
"DDInter1971",
"DDInter1588"
] | Zonisamide | Ribociclib | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
306,
24,
351
]
],
[
[
306,
24,
222
],
[
222,
23,
351
]
],
[
[
306,
24,
283
],
[
283,
62,
351
]
],
[
[
306,
63,
597
],
[
597,
24,... | [
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB00242 | DB09498 | 1,064 | 810 | [
"DDInter392",
"DDInter1715"
] | Cladribine | Strontium chloride Sr-89 | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Major | 2 | [
[
[
1064,
25,
810
]
],
[
[
1064,
25,
552
],
[
552,
24,
810
]
],
[
[
1064,
25,
689
],
[
689,
63,
810
]
],
[
[
1064,
64,
273
],
[
273,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carmustine"
],
[
"Carmustine"... | Cladribine may lead to a major life threatening interaction when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Cladribine may lead to a major life threatening interaction when taken with Axicabtagene ciloleucel and Axicabtag... |
DB00631 | DB00660 | 372 | 1,470 | [
"DDInter405",
"DDInter1163"
] | Clofarabine | Metaxalone | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Metaxalone is a moderate to strong muscle relaxant used in the symptomatic treatment of musculoskeletal pain caused by strains, sprains, and other musculoskeletal conditions. It is marketed by King Pharmaceuticals under the brand name Skelaxin®. Its main mechanism of action is thought to involve general central nervous... | Moderate | 1 | [
[
[
372,
24,
1470
]
],
[
[
372,
21,
28681
],
[
28681,
60,
1470
]
],
[
[
372,
63,
663
],
[
663,
24,
1470
]
],
[
[
372,
24,
1532
],
[
1532,
... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metaxalone"
]
],
[
[
"Clofarabine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side... | Clofarabine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Metaxalone (Compound)
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases whe... |
DB00295 | DB14509 | 475 | 1,399 | [
"DDInter1244",
"DDInter1081"
] | Morphine | Lithium carbonate | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
475,
24,
1399
]
],
[
[
475,
24,
506
],
[
506,
24,
1399
]
],
[
[
475,
63,
701
],
[
701,
24,
1399
]
],
[
[
475,
62,
1505
],
[
1505,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
],... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Clemas... |
DB00332 | DB00835 | 1,089 | 100 | [
"DDInter970",
"DDInter245"
] | Ipratropium | Brompheniramine | Ipratropium is a quaternary ammonium derivative of [atropine] that acts as an anticholinergic agent. It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption. Ipratropium as a therapeutic agent was developed by Boehringer Ingelheim and its... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1089,
24,
100
]
],
[
[
1089,
24,
832
],
[
832,
24,
100
]
],
[
[
1089,
24,
211
],
[
211,
63,
100
]
],
[
[
1089,
6,
8374
],
[
8374,
... | [
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Ipratropium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
... | Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Ipratropium may cause a moderate interaction that could exacerbate diseases when taken with Tolter... |
DB10315 | DB12332 | 1,137 | 1,619 | [
"DDInter1127",
"DDInter1626"
] | Measles virus vaccine live attenuated | Rucaparib | Measles virus vaccine live attenuated is a live virus vaccine for simultaneous vaccination against measles, which is a common childhood disease. The vaccine is prepared from the attenuated line of measles virus, derived from Enders' attenuated Edmonston strain and propagated in chick embryo cell culture. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Major | 2 | [
[
[
1137,
25,
1619
]
],
[
[
1137,
64,
259
],
[
259,
24,
1619
]
],
[
[
1137,
25,
1019
],
[
1019,
24,
1619
]
],
[
[
1137,
63,
617
],
[
617,
... | [
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rucaparib"
]
],
[
[
"Measles virus vaccine live attenuated",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilo... | Measles virus vaccine live attenuated may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib
Measles virus vaccine live attenuated may lead to a major life threatening interaction when taken wit... |
DB00518 | DB00582 | 510 | 1,622 | [
"DDInter35",
"DDInter1946"
] | Albendazole | Voriconazole | A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38) | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
510,
24,
1622
]
],
[
[
510,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
510,
21,
29076
],
[
29076,
60,
1622
]
],
[
[
510,
62,
752
],
[
752,
... | [
[
[
"Albendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Albendazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Albendazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Albendazole (Compound) causes Liver function test abnormal (Side Effect) and Liver function test abnormal (Side Effect) is caused by Voriconazole (Compound)
Albendazole may cause a minor interaction that can limit clinical ... |
DB00241 | DB00405 | 288 | 128 | [
"DDInter257",
"DDInter517"
] | Butalbital | Dexbrompheniramine | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
288,
24,
128
]
],
[
[
288,
24,
662
],
[
662,
63,
128
]
],
[
[
288,
40,
1023
],
[
1023,
24,
128
]
],
[
[
288,
25,
475
],
[
475,
2... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Butalbital (Compound) resembles Pentobarbital (Compound) and Pentobarbital may cause a moderate in... |
DB01294 | DB01309 | 266 | 1,254 | [
"DDInter215",
"DDInter933"
] | Bismuth subsalicylate | Insulin glulisine | Bismuth subsalicylate is an antacid and anti-diarrheal agent. Exhibiting antibacterial and gastroprotective properties, bismuth subsalicylate is an insoluble salt of [salicylic acid] linked to trivalent [bismuth cation]. Each molecule of bismuth subsalicylate contains 58% bismuth and 42% salicylate by weight. Bismuth s... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
266,
24,
1254
]
],
[
[
266,
63,
1669
],
[
1669,
24,
1254
]
],
[
[
266,
63,
1669
],
[
1669,
1,
1545
],
[
1545,
24,
1254
]
],
[
[
266,
... | [
[
[
"Bismuth subsalicylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Bismuth subsalicylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Bismuth subsalicylate may cause a moderate interaction that could exacerbate diseases when taken with Minocycline and Minocycline may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Bismuth subsalicylate may cause a moderate interaction that could exacerbate diseases when t... |
DB00612 | DB01362 | 1,121 | 497 | [
"DDInter216",
"DDInter960"
] | Bisoprolol | Iohexol | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Moderate | 1 | [
[
[
1121,
24,
497
]
],
[
[
1121,
24,
258
],
[
258,
40,
497
]
],
[
[
1121,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1121,
1,
88
],
[
88,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
]
],
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
],
[
... | Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Bisoprolol (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Bisoprolol (Compound) resembles Metopr... |
DB05294 | DB08875 | 1,069 | 1,618 | [
"DDInter1917",
"DDInter262"
] | Vandetanib | Cabozantinib | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1069,
25,
1618
]
],
[
[
1069,
23,
1135
],
[
1135,
62,
1618
]
],
[
[
1069,
62,
112
],
[
112,
23,
1618
]
],
[
[
1069,
24,
384
],
[
384,
... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Vandetanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",... | Vandetanib may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronida... |
DB00069 | DB00570 | 367 | 147 | [
"DDInter946",
"DDInter1936"
] | Interferon alfacon-1 | Vinblastine | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
367,
24,
147
]
],
[
[
367,
24,
134
],
[
134,
24,
147
]
],
[
[
367,
24,
896
],
[
896,
62,
147
]
],
[
[
367,
24,
63
],
[
63,
23,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinore... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00910 | DB13749 | 1,041 | 1,473 | [
"DDInter1394",
"DDInter1116"
] | Paricalcitol | Magnesium gluconate | Paricalcitol is a synthetic vitamin D analog. Paricalcitol has been used to reduce parathyroid hormone levels. Paricalcitol is indicated for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure. | Magnesium gluconate is a magnesium salt of gluconate. It demonstrates the highest oral bioavailability of magnesium salts and is used as a mineral supplement. Magnesium is ubiquitous in the human body, and is naturally present in many foods, added to other food products, available as a dietary supplement and used as an... | Moderate | 1 | [
[
[
1041,
24,
1473
]
],
[
[
1041,
63,
544
],
[
544,
24,
1473
]
],
[
[
1041,
64,
386
],
[
386,
24,
1473
]
],
[
[
1041,
25,
1098
],
[
1098,
... | [
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium gluconate"
]
],
[
[
"Paricalcitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulf... | Paricalcitol may cause a moderate interaction that could exacerbate diseases when taken with Magnesium sulfate and Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium gluconate
Paricalcitol may lead to a major life threatening interaction when taken with Cholecalc... |
DB00414 | DB00795 | 590 | 50 | [
"DDInter16",
"DDInter1725"
] | Acetohexamide | Sulfasalazine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
590,
24,
50
]
],
[
[
590,
24,
712
],
[
712,
1,
50
]
],
[
[
590,
63,
161
],
[
161,
1,
50
]
],
[
[
590,
63,
305
],
[
305,
24,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine (Compound) resembles Sulfasalazine (Compound)
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resembles Sulfasala... |
DB00559 | DB00990 | 152 | 1,547 | [
"DDInter223",
"DDInter705"
] | Bosentan | Exemestane | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Moderate | 1 | [
[
[
152,
24,
1547
]
],
[
[
152,
24,
891
],
[
891,
40,
1547
]
],
[
[
152,
6,
8374
],
[
8374,
45,
1547
]
],
[
[
152,
21,
28757
],
[
28757,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exemestane"
]
],
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[
... | Bosentan may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone (Compound) resembles Exemestane (Compound)
Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Exemestane (Compound)
Bosentan (Compound) causes Dyspepsia (Side Effect) and Dyspepsia (... |
DB00562 | DB06691 | 1,014 | 849 | [
"DDInter188",
"DDInter1155"
] | Benzthiazide | Mepyramine | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1014,
24,
849
]
],
[
[
1014,
63,
1648
],
[
1648,
24,
849
]
],
[
[
1014,
1,
811
],
[
811,
24,
849
]
],
[
[
1014,
24,
407
],
[
407,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Benzthiazide (Compound) resembles Metolazone (Compound) and Metolazone may cause a moderate interaction that... |
DB00860 | DB11113 | 891 | 657 | [
"DDInter1513",
"DDInter307"
] | Prednisolone | Castor oil | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (_Ricinus communis_ L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of , which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic... | Moderate | 1 | [
[
[
891,
24,
657
]
],
[
[
891,
24,
1326
],
[
1326,
24,
657
]
],
[
[
891,
62,
228
],
[
228,
24,
657
]
],
[
[
891,
25,
739
],
[
739,
2... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Castor oil"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenamide"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenamide and Diclofenamide may cause a moderate interaction that could exacerbate diseases when taken with Castor oil
Prednisolone may cause a minor interaction that can limit clinical effects when taken with Dofetilide an... |
DB00307 | DB14783 | 1,101 | 287 | [
"DDInter202",
"DDInter574"
] | Bexarotene | Diroximel fumarate | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1101,
24,
287
]
],
[
[
1101,
64,
1560
],
[
1560,
24,
287
]
],
[
[
1101,
24,
384
],
[
384,
24,
287
]
],
[
[
1101,
63,
599
],
[
599,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pegaspargase"
],
[
"... | Bexarotene may lead to a major life threatening interaction when taken with Pegaspargase and Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisi... |
DB12332 | DB14783 | 1,619 | 287 | [
"DDInter1626",
"DDInter574"
] | Rucaparib | Diroximel fumarate | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
1619,
24,
287
]
],
[
[
1619,
63,
1101
],
[
1101,
24,
287
]
],
[
[
1619,
64,
478
],
[
478,
24,
287
]
],
[
[
1619,
64,
1510
],
[
1510,
... | [
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Rucaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Rucaparib may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may ca... |
DB00222 | DB01175 | 245 | 318 | [
"DDInter825",
"DDInter672"
] | Glimepiride | Escitalopram | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
245,
24,
318
]
],
[
[
245,
63,
1230
],
[
1230,
1,
318
]
],
[
[
245,
21,
28641
],
[
28641,
60,
318
]
],
[
[
245,
25,
86
],
[
86,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Glimepiride (Compound) causes Hot flush (Side Effect) and Hot flush (Side Effect) is caused by Escitalopram (Compound)
Glimepiride may lead to a major life t... |
DB00694 | DB09080 | 51 | 144 | [
"DDInter485",
"DDInter1331"
] | Daunorubicin | Olodaterol | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
51,
24,
144
]
],
[
[
51,
23,
1247
],
[
1247,
23,
144
]
],
[
[
51,
24,
956
],
[
956,
24,
144
]
],
[
[
51,
25,
1011
],
[
1011,
24,... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Olodaterol
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Norfloxac... |
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