drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01081 | DB01174 | 1,688 | 697 | [
"DDInter571",
"DDInter1442"
] | Diphenoxylate | Phenobarbital | A meperidine congener used as an antidiarrheal, usually in combination with atropine. At high doses, it acts like morphine. Its unesterified metabolite difenoxin has similar properties and is used similarly. It has little or no analgesic activity. This medication is classified as a Schedule V under the Controlled Subst... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
1688,
24,
697
]
],
[
[
1688,
63,
759
],
[
759,
1,
697
]
],
[
[
1688,
63,
536
],
[
536,
40,
697
]
],
[
[
1688,
24,
649
],
[
649,
... | [
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Diphenoxylate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Diphenoxylate may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenobarbit... |
DB00445 | DB01030 | 322 | 869 | [
"DDInter655",
"DDInter1835"
] | Epirubicin | Topotecan | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
322,
24,
869
]
],
[
[
322,
5,
11618
],
[
11618,
44,
869
]
],
[
[
322,
7,
17332
],
[
17332,
46,
869
]
],
[
[
322,
18,
20113
],
[
20113,... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Epirubicin",
"{u} (Compound) treats {v} (Disease)",
"peripheral nervous system neoplasm"
],
[
"peripheral nervous syste... | Epirubicin (Compound) treats peripheral nervous system neoplasm (Disease) and peripheral nervous system neoplasm (Disease) is treated by Topotecan (Compound)
Epirubicin (Compound) upregulates ALDH5A1 (Gene) and ALDH5A1 (Gene) is upregulated by Topotecan (Compound)
Epirubicin (Compound) downregulates IER3 (Gene) and IER... |
DB00495 | DB01005 | 139 | 995 | [
"DDInter1961",
"DDInter894"
] | Zidovudine | Hydroxyurea | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | Moderate | 1 | [
[
[
139,
24,
995
]
],
[
[
139,
21,
28883
],
[
28883,
60,
995
]
],
[
[
139,
24,
1238
],
[
1238,
24,
995
]
],
[
[
139,
24,
869
],
[
869,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyurea"
]
],
[
[
"Zidovudine",
"{u} (Compound) causes {v} (Side Effect)",
"Skin disorder"
],
[
"Skin disorder",
"{u} (Side Effect... | Zidovudine (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Hydroxyurea (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Pentostatin and Pentostatin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00072 | DB01030 | 550 | 869 | [
"DDInter1846",
"DDInter1835"
] | Trastuzumab | Topotecan | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
550,
24,
869
]
],
[
[
550,
24,
1270
],
[
1270,
63,
869
]
],
[
[
550,
63,
1184
],
[
1184,
24,
869
]
],
[
[
550,
24,
599
],
[
599,
... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protei... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative and Tuberculin purified protein derivative may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Trastuzumab may cause a moderate interaction that could ... |
DB01233 | DB01618 | 1,311 | 776 | [
"DDInter1197",
"DDInter1239"
] | Metoclopramide | Molindone | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Major | 2 | [
[
[
1311,
25,
776
]
],
[
[
1311,
6,
2250
],
[
2250,
45,
776
]
],
[
[
1311,
21,
29557
],
[
29557,
60,
776
]
],
[
[
1311,
63,
100
],
[
100,
... | [
[
[
"Metoclopramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Molindone"
]
],
[
[
"Metoclopramide",
"{u} (Compound) binds {v} (Gene)",
"DRD2"
],
[
"DRD2",
"{u} (Gene) is bound by {v} (Compound)",
"Moli... | Metoclopramide (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Molindone (Compound)
Metoclopramide (Compound) causes Movements involuntary (Side Effect) and Movements involuntary (Side Effect) is caused by Molindone (Compound)
Metoclopramide may cause a moderate interaction that could exacerbate diseases when ... |
DB00001 | DB08896 | 1,578 | 292 | [
"DDInter1037",
"DDInter1576"
] | Lepirudin | Regorafenib | Lepirudin is a recombinant hirudin formed by 65 amino acids that acts as a highly specific and direct thrombin inhibitor.[L41539,L41569] Natural hirudin is an endogenous anticoagulant found in _Hirudo medicinalis_ leeches. Lepirudin is produced in yeast cells and is identical to natural hirudin except for the absence o... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Major | 2 | [
[
[
1578,
25,
292
]
],
[
[
1578,
24,
643
],
[
643,
24,
292
]
],
[
[
1578,
24,
41
],
[
41,
63,
292
]
],
[
[
1578,
25,
553
],
[
553,
2... | [
[
[
"Lepirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Regorafenib"
]
],
[
[
"Lepirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desvenlafaxine"
],
[
"Desvenl... | Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Desvenlafaxine and Desvenlafaxine may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib
Lepirudin may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipra... |
DB00999 | DB09133 | 504 | 1,527 | [
"DDInter883",
"DDInter965"
] | Hydrochlorothiazide | Iothalamic acid | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Moderate | 1 | [
[
[
504,
24,
1527
]
],
[
[
504,
1,
1577
],
[
1577,
24,
1527
]
],
[
[
504,
40,
178
],
[
178,
24,
1527
]
],
[
[
504,
63,
1648
],
[
1648,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Hydrochlorothiazide",
"{u} (Compound) resembles {v} (Compound)",
"Hydroflumethiazide"
],
[
"Hydroflumeth... | Hydrochlorothiazide (Compound) resembles Hydroflumethiazide (Compound) and Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Iothalamic acid
Hydrochlorothiazide (Compound) resembles Polythiazide (Compound) and Polythiazide may cause a moderate interaction that could exac... |
DB00545 | DB00572 | 751 | 85 | [
"DDInter1548",
"DDInter136"
] | Pyridostigmine | Atropine | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
751,
24,
85
]
],
[
[
751,
63,
19
],
[
19,
24,
85
]
],
[
[
751,
21,
28722
],
[
28722,
60,
85
]
],
[
[
751,
24,
1511
],
[
1511,
63... | [
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
... | Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Pyridostigmine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Atropine (Compou... |
DB06081 | DB12364 | 1,046 | 1,421 | [
"DDInter286",
"DDInter200"
] | Caplacizumab | Betrixaban | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
1046,
25,
1421
]
],
[
[
1046,
23,
297
],
[
297,
23,
1421
]
],
[
[
1046,
23,
1631
],
[
1631,
62,
1421
]
],
[
[
1046,
24,
992
],
[
992,
... | [
[
[
"Caplacizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Caplacizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
... | Caplacizumab may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Betrixaban
Caplacizumab may cause a minor interaction that can limit clinical effects when taken with Turmeric and Turmeric may cause a... |
DB01004 | DB01041 | 563 | 770 | [
"DDInter806",
"DDInter1789"
] | Ganciclovir | Thalidomide | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
563,
24,
770
]
],
[
[
563,
63,
1668
],
[
1668,
1,
770
]
],
[
[
563,
21,
29177
],
[
29177,
60,
770
]
],
[
[
563,
24,
4
],
[
4,
63... | [
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Ganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenalidomide"
],
... | Ganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Lenalidomide and Lenalidomide (Compound) resembles Thalidomide (Compound)
Ganciclovir (Compound) causes Musculoskeletal stiffness (Side Effect) and Musculoskeletal stiffness (Side Effect) is caused by Thalidomide (Compound)
Ganc... |
DB01064 | DB09241 | 1,148 | 1,629 | [
"DDInter987",
"DDInter1186"
] | Isoprenaline | Methylene blue | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Moderate | 1 | [
[
[
1148,
24,
1629
]
],
[
[
1148,
63,
1052
],
[
1052,
24,
1629
]
],
[
[
1148,
24,
1190
],
[
1190,
24,
1629
]
],
[
[
1148,
24,
1032
],
[
10... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylene blue"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ritodrine"
],
... | Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Ritodrine and Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Ketamine and Ke... |
DB04932 | DB11095 | 1,564 | 235 | [
"DDInter491",
"DDInter505"
] | Defibrotide | Desirudin | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Major | 2 | [
[
[
1564,
25,
235
]
],
[
[
1564,
23,
297
],
[
297,
23,
235
]
],
[
[
1564,
63,
1100
],
[
1100,
24,
235
]
],
[
[
1564,
24,
643
],
[
643,
... | [
[
[
"Defibrotide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
]
],
[
[
"Defibrotide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clove",
"{... | Defibrotide may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Desirudin
Defibrotide may cause a moderate interaction that could exacerbate diseases when taken with Venlafaxine and Venlafaxine may ca... |
DB01082 | DB01249 | 1,448 | 258 | [
"DDInter1713",
"DDInter958"
] | Streptomycin | Iodixanol | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
1448,
25,
258
]
],
[
[
1448,
25,
497
],
[
497,
1,
258
]
],
[
[
1448,
21,
28748
],
[
28748,
60,
258
]
],
[
[
1448,
64,
1680
],
[
1680,
... | [
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Streptomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Com... | Streptomycin may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Streptomycin (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Streptomycin may lead to a major life threatening interaction when ... |
DB00445 | DB09054 | 322 | 384 | [
"DDInter655",
"DDInter905"
] | Epirubicin | Idelalisib | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
322,
24,
384
]
],
[
[
322,
25,
318
],
[
318,
23,
384
]
],
[
[
322,
64,
1230
],
[
1230,
23,
384
]
],
[
[
322,
24,
1627
],
[
1627,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escitalo... | Epirubicin may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Epirubicin may lead to a major life threatening interaction when taken with Citalopram and Citalopram may cause a minor inter... |
DB00486 | DB11160 | 1,614 | 337 | [
"DDInter1253",
"DDInter1459"
] | Nabilone | Phenyltoloxamine | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
1614,
24,
337
]
],
[
[
1614,
24,
820
],
[
820,
24,
337
]
],
[
[
1614,
63,
999
],
[
999,
24,
337
]
],
[
[
1614,
40,
530
],
[
530,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine ... |
DB06772 | DB11901 | 310 | 913 | [
"DDInter259",
"DDInter107"
] | Cabazitaxel | Apalutamide | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
310,
24,
913
]
],
[
[
310,
63,
112
],
[
112,
23,
913
]
],
[
[
310,
24,
110
],
[
110,
62,
913
]
],
[
[
310,
63,
600
],
[
600,
24,... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab ve... |
DB01211 | DB08816 | 609 | 578 | [
"DDInter393",
"DDInter1802"
] | Clarithromycin | Ticagrelor | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Major | 2 | [
[
[
609,
25,
578
]
],
[
[
609,
6,
4973
],
[
4973,
45,
578
]
],
[
[
609,
54,
19146
],
[
19146,
15,
578
]
],
[
[
609,
21,
28646
],
[
28646,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ticagrelor"
]
],
[
[
"Clarithromycin",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"T... | Clarithromycin (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Ticagrelor (Compound)
Clarithromycin (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Ticagrelor (Compound)
Clarithromycin (Compound) causes Unspecifi... |
DB00011 | DB00515 | 1,451 | 589 | [
"DDInter944",
"DDInter387"
] | Interferon alfa-n1 | Cisplatin | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
1451,
24,
589
]
],
[
[
1451,
24,
1468
],
[
1468,
63,
589
]
],
[
[
1451,
24,
367
],
[
367,
24,
589
]
],
[
[
1451,
25,
1477
],
[
1477,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Interfer... |
DB00759 | DB00774 | 1,620 | 1,577 | [
"DDInter1783",
"DDInter889"
] | Tetracycline | Hydroflumethiazide | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Minor | 0 | [
[
[
1620,
23,
1577
]
],
[
[
1620,
23,
359
],
[
359,
40,
1577
]
],
[
[
1620,
62,
323
],
[
323,
40,
1577
]
],
[
[
1620,
23,
504
],
[
504,
... | [
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazide"
]
],
[
[
"Tetracycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chlorothiazide"
... | Tetracycline may cause a minor interaction that can limit clinical effects when taken with Chlorothiazide and Chlorothiazide (Compound) resembles Hydroflumethiazide (Compound)
Tetracycline may cause a minor interaction that can limit clinical effects when taken with Bendroflumethiazide and Bendroflumethiazide (Compound... |
DB01229 | DB11003 | 973 | 748 | [
"DDInter1377",
"DDInter100"
] | Paclitaxel | Anthrax vaccine | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
973,
24,
748
]
],
[
[
973,
63,
168
],
[
168,
24,
748
]
],
[
[
973,
25,
676
],
[
676,
63,
748
]
],
[
[
973,
24,
1683
],
[
1683,
2... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Paclitaxel may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib m... |
DB00384 | DB09268 | 1,275 | 1,662 | [
"DDInter1859",
"DDInter1464"
] | Triamterene | Picosulfuric acid | Triamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. It works by promoting the excretion of sodium ions and water while decreasing the potassium excretion in the distal part of the nephron in the kidneys by working on the lumenal side. Since it a... | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
1275,
24,
1662
]
],
[
[
1275,
24,
708
],
[
708,
24,
1662
]
],
[
[
1275,
62,
964
],
[
964,
24,
1662
]
],
[
[
1275,
63,
475
],
[
475,
... | [
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Triamterene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
... | Triamterene may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Triamterene may cause a minor interaction that can limit clinical effects when taken with Doxycycl... |
DB00214 | DB13928 | 1,028 | 1,385 | [
"DDInter1836",
"DDInter1660"
] | Torasemide | Semaglutide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
1028,
24,
1385
]
],
[
[
1028,
24,
891
],
[
891,
24,
1385
]
],
[
[
1028,
63,
1685
],
[
1685,
24,
1385
]
],
[
[
1028,
24,
891
],
[
891,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
],
[... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Prednisolone and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Insulin human an... |
DB00261 | DB09074 | 702 | 1,362 | [
"DDInter93",
"DDInter1327"
] | Anagrelide | Olaparib | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
702,
24,
1362
]
],
[
[
702,
25,
576
],
[
576,
24,
1362
]
],
[
[
702,
24,
2
],
[
2,
24,
1362
]
],
[
[
702,
63,
491
],
[
491,
24,
... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methadone"
],
[
"Methadone",
... | Anagrelide may lead to a major life threatening interaction when taken with Methadone and Methadone may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Alosetron and Alosetron may cause a mode... |
DB01406 | DB06616 | 984 | 594 | [
"DDInter472",
"DDInter224"
] | Danazol | Bosutinib | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
984,
24,
594
]
],
[
[
984,
63,
883
],
[
883,
1,
594
]
],
[
[
984,
7,
2963
],
[
2963,
45,
594
]
],
[
[
984,
18,
9206
],
[
9206,
4... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
[
"Gef... | Danazol may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Bosutinib (Compound)
Danazol (Compound) upregulates CSK (Gene) and CSK (Gene) is bound by Bosutinib (Compound)
Danazol (Compound) downregulates PKMYT1 (Gene) and PKMYT1 (Gene) is bound by... |
DB00603 | DB00688 | 303 | 955 | [
"DDInter1137",
"DDInter1251"
] | Medroxyprogesterone acetate | Mycophenolate mofetil | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Major | 2 | [
[
[
303,
25,
955
]
],
[
[
303,
25,
1096
],
[
1096,
40,
955
]
],
[
[
303,
6,
3486
],
[
3486,
45,
955
]
],
[
[
303,
7,
8924
],
[
8924,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolate mofetil"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mycophenolic... | Medroxyprogesterone acetate may lead to a major life threatening interaction when taken with Mycophenolic acid and Mycophenolic acid (Compound) resembles Mycophenolate mofetil (Compound)
Medroxyprogesterone acetate (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Mycophenolate mofetil (Compound)
Medroxyprog... |
DB00026 | DB01229 | 1,184 | 973 | [
"DDInter94",
"DDInter1378"
] | Anakinra | Paclitaxel (protein-bound) | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
1184,
24,
973
]
],
[
[
1184,
24,
310
],
[
310,
63,
973
]
],
[
[
1184,
24,
134
],
[
134,
24,
973
]
],
[
[
1184,
25,
980
],
[
980,
... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Anakinra may... |
DB00512 | DB00988 | 91 | 817 | [
"DDInter1916",
"DDInter584"
] | Vancomycin | Dopamine | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Moderate | 1 | [
[
[
91,
24,
817
]
],
[
[
91,
24,
532
],
[
532,
1,
817
]
],
[
[
91,
21,
28722
],
[
28722,
60,
817
]
],
[
[
91,
24,
123
],
[
123,
63,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Dopamine (Compound)
Vancomycin (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Dopamine (Compound)
Vancomycin may cause a moderate interaction that could... |
DB01229 | DB08827 | 973 | 990 | [
"DDInter1377",
"DDInter1085"
] | Paclitaxel | Lomitapide | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
973,
24,
990
]
],
[
[
973,
63,
1080
],
[
1080,
1,
990
]
],
[
[
973,
6,
8374
],
[
8374,
45,
990
]
],
[
[
973,
21,
28701
],
[
28701,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Paclitaxel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Paclitaxel (Compound) causes Discomfort (Side Effect) and Discomfo... |
DB00261 | DB01142 | 702 | 1,264 | [
"DDInter93",
"DDInter593"
] | Anagrelide | Doxepin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Major | 2 | [
[
[
702,
25,
1264
]
],
[
[
702,
25,
508
],
[
508,
24,
1264
]
],
[
[
702,
24,
1405
],
[
1405,
25,
1264
]
],
[
[
702,
6,
7950
],
[
7950,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Doxepin"
]
],
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Promazine"
],
[
"Promazine",
"{u} may ca... | Anagrelide may lead to a major life threatening interaction when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine may l... |
DB00691 | DB08938 | 1,058 | 1,384 | [
"DDInter1237",
"DDInter1112"
] | Moexipril | Magaldrate | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
1058,
23,
1384
]
],
[
[
1058,
24,
167
],
[
167,
23,
1384
]
],
[
[
1058,
40,
610
],
[
610,
23,
1384
]
],
[
[
1058,
63,
1573
],
[
1573,
... | [
[
[
"Moexipril",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Moexipril (Compound) resembles Enalapril (Compound) and Enalapril may cause a minor interaction that can li... |
DB08893 | DB08912 | 271 | 1,040 | [
"DDInter1229",
"DDInter462"
] | Mirabegron | Dabrafenib | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Minor | 0 | [
[
[
271,
23,
1040
]
],
[
[
271,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
271,
21,
28900
],
[
28900,
60,
1040
]
],
[
[
271,
62,
1101
],
[
1101,... | [
[
[
"Mirabegron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dabrafenib"
]
],
[
[
"Mirabegron",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Mirabegron (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Mirabegron (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Dabrafenib (Compound)
Mirabegron may cause a minor interaction that can limit clinical effects when taken with Bexarotene an... |
DB00841 | DB00912 | 532 | 473 | [
"DDInter577",
"DDInter1581"
] | Dobutamine | Repaglinide | A beta-1 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
532,
24,
473
]
],
[
[
532,
21,
28763
],
[
28763,
60,
473
]
],
[
[
532,
63,
73
],
[
73,
24,
473
]
],
[
[
532,
24,
1148
],
[
1148,
... | [
[
[
"Dobutamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Dobutamine",
"{u} (Compound) causes {v} (Side Effect)",
"Chest pain"
],
[
"Chest pain",
"{u} (Side Effect) is c... | Dobutamine (Compound) causes Chest pain (Side Effect) and Chest pain (Side Effect) is caused by Repaglinide (Compound)
Dobutamine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Re... |
DB06688 | DB15699 | 1,430 | 652 | [
"DDInter1677",
"DDInter232"
] | Sipuleucel-T | Brexucabtagene autoleucel | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Moderate | 1 | [
[
[
1430,
24,
652
]
],
[
[
1430,
63,
259
],
[
259,
24,
652
]
],
[
[
1430,
24,
270
],
[
270,
24,
652
]
],
[
[
1430,
24,
976
],
[
976,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonace... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Oc... |
DB00981 | DB01409 | 1,528 | 1,415 | [
"DDInter1463",
"DDInter1815"
] | Physostigmine (ophthalmic) | Tiotropium | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L... | Moderate | 1 | [
[
[
1528,
24,
1415
]
],
[
[
1528,
21,
28722
],
[
28722,
60,
1415
]
],
[
[
1528,
63,
752
],
[
752,
23,
1415
]
],
[
[
1528,
63,
146
],
[
146... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tiotropium"
]
],
[
[
"Physostigmine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caus... | Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Tiotropium
Physostigmine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Tiotropium (Compound)
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidi... |
DB00358 | DB01001 | 1,010 | 688 | [
"DDInter1140",
"DDInter1632"
] | Mefloquine | Salbutamol | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1010,
24,
688
]
],
[
[
1010,
24,
455
],
[
455,
24,
688
]
],
[
[
1010,
24,
1148
],
[
1148,
63,
688
]
],
[
[
1010,
6,
8374
],
[
8374,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isop... |
DB00055 | DB11703 | 834 | 405 | [
"DDInter605",
"DDInter9"
] | Drotrecogin alfa | Acalabrutinib | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
834,
25,
405
]
],
[
[
834,
24,
383
],
[
383,
24,
405
]
],
[
[
834,
25,
804
],
[
804,
25,
405
]
],
[
[
834,
25,
710
],
[
710,
64,... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
]... | Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Drotrecogin alfa may lead to a major life threatening interaction when taken with S... |
DB08880 | DB14730 | 1,510 | 1,412 | [
"DDInter1771",
"DDInter264"
] | Teriflunomide | Calaspargase pegol | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Major | 2 | [
[
[
1510,
25,
1412
]
],
[
[
1510,
25,
250
],
[
250,
24,
1412
]
],
[
[
1510,
64,
1439
],
[
1439,
24,
1412
]
],
[
[
1510,
63,
1144
],
[
1144... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Blinatumomab"
],
[
"Blinatumo... | Teriflunomide may lead to a major life threatening interaction when taken with Blinatumomab and Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Teriflunomide may lead to a major life threatening interaction when taken with Ipilimumab and Ipilimumab may cau... |
DB09080 | DB14509 | 144 | 1,399 | [
"DDInter1331",
"DDInter1081"
] | Olodaterol | Lithium carbonate | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
144,
24,
1399
]
],
[
[
144,
63,
874
],
[
874,
23,
1399
]
],
[
[
144,
24,
1385
],
[
1385,
24,
1399
]
],
[
[
144,
63,
1374
],
[
1374,
... | [
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Olodaterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
],
... | Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Olodaterol may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide an... |
DB12245 | DB12332 | 823 | 1,619 | [
"DDInter1863",
"DDInter1626"
] | Triclabendazole | Rucaparib | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
823,
24,
1619
]
],
[
[
823,
62,
112
],
[
112,
23,
1619
]
],
[
[
823,
63,
87
],
[
87,
24,
1619
]
],
[
[
823,
24,
180
],
[
180,
63... | [
[
[
"Triclabendazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Triclabendazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
]... | Triclabendazole may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Triclabendazole may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine ... |
DB01177 | DB06663 | 77 | 1,154 | [
"DDInter904",
"DDInter1398"
] | Idarubicin | Pasireotide | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
77,
25,
1154
]
],
[
[
77,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
77,
62,
112
],
[
112,
23,
1154
]
],
[
[
77,
63,
663
],
[
663,
... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Idarubicin",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caused b... | Idarubicin (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Idarubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken... |
DB00374 | DB00569 | 1,061 | 553 | [
"DDInter1852",
"DDInter775"
] | Treprostinil | Fondaparinux | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Fondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. It is structurally similar to polymeric glycosaminoglycan heparin and heparan sulfate (HS) when they are cleaved into monomeric units. The monomeric sequence in he... | Major | 2 | [
[
[
1061,
25,
553
]
],
[
[
1061,
21,
28789
],
[
28789,
60,
553
]
],
[
[
1061,
23,
539
],
[
539,
62,
553
]
],
[
[
1061,
24,
972
],
[
972,
... | [
[
[
"Treprostinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
]
],
[
[
"Treprostinil",
"{u} (Compound) causes {v} (Side Effect)",
"Loss of consciousness"
],
[
"Loss of consciousness",
"{u} (Side ... | Treprostinil (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Fondaparinux (Compound)
Treprostinil may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects w... |
DB00361 | DB00363 | 134 | 695 | [
"DDInter1939",
"DDInter419"
] | Vinorelbine | Clozapine | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Major | 2 | [
[
[
134,
25,
695
]
],
[
[
134,
6,
12523
],
[
12523,
45,
695
]
],
[
[
134,
18,
17366
],
[
17366,
57,
695
]
],
[
[
134,
24,
112
],
[
112,
... | [
[
[
"Vinorelbine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clozapine"
]
],
[
[
"Vinorelbine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Clozap... | Vinorelbine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Clozapine (Compound)
Vinorelbine (Compound) downregulates C2CD5 (Gene) and C2CD5 (Gene) is downregulated by Clozapine (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronid... |
DB00860 | DB00945 | 891 | 1,479 | [
"DDInter1513",
"DDInter20"
] | Prednisolone | Acetylsalicylic acid | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
891,
24,
1479
]
],
[
[
891,
24,
1338
],
[
1338,
24,
1479
]
],
[
[
891,
7,
2900
],
[
2900,
45,
1479
]
],
[
[
891,
6,
4973
],
[
4973,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic ... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Meclofenamic acid and Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid
Prednisolone (Compound) upregulates NFKBIA (Gene) and NFKBIA (Gene) is bound by Acetyl... |
DB00524 | DB06691 | 811 | 849 | [
"DDInter1199",
"DDInter1155"
] | Metolazone | Mepyramine | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
811,
24,
849
]
],
[
[
811,
63,
1648
],
[
1648,
24,
849
]
],
[
[
811,
40,
1014
],
[
1014,
24,
849
]
],
[
[
811,
24,
407
],
[
407,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Metolazone (Compound) resembles Benzthiazide (Compound) and Benzthiazide may cause a moderate interaction that... |
DB00176 | DB00434 | 529 | 13 | [
"DDInter770",
"DDInter459"
] | Fluvoxamine | Cyproheptadine | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
529,
24,
13
]
],
[
[
529,
24,
1219
],
[
1219,
63,
13
]
],
[
[
529,
21,
29455
],
[
29455,
60,
13
]
],
[
[
529,
25,
506
],
[
506,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
],
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Fluvoxamine (Compound) causes Agranulocytosis (Side Effect) and Agranulocytosis (Side Effect) is caused by Cy... |
DB01143 | DB01193 | 923 | 819 | [
"DDInter65",
"DDInter12"
] | Amifostine | Acebutolol | A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia. | A cardioselective beta-adrenergic antagonist with little effect on the bronchial receptors. The drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action. | Moderate | 1 | [
[
[
923,
24,
819
]
],
[
[
923,
63,
887
],
[
887,
1,
819
]
],
[
[
923,
21,
29005
],
[
29005,
60,
819
]
],
[
[
923,
24,
885
],
[
885,
... | [
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acebutolol"
]
],
[
[
"Amifostine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pindolol"
],
[
... | Amifostine may cause a moderate interaction that could exacerbate diseases when taken with Pindolol and Pindolol (Compound) resembles Acebutolol (Compound)
Amifostine (Compound) causes Dermatitis exfoliative (Side Effect) and Dermatitis exfoliative (Side Effect) is caused by Acebutolol (Compound)
Amifostine may cause a... |
DB08870 | DB10583 | 850 | 949 | [
"DDInter228",
"DDInter415"
] | Brentuximab vedotin | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
850,
24,
949
]
],
[
[
850,
63,
589
],
[
589,
24,
949
]
],
[
[
850,
24,
250
],
[
250,
24,
949
]
],
[
[
850,
64,
1377
],
[
1377,
2... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerba... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Brentuximab vedotin may cause a moderate interaction th... |
DB00358 | DB00637 | 1,010 | 1,557 | [
"DDInter1140",
"DDInter128"
] | Mefloquine | Astemizole | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
1010,
24,
1557
]
],
[
[
1010,
25,
1568
],
[
1568,
64,
1557
]
],
[
[
1010,
6,
8374
],
[
8374,
45,
1557
]
],
[
[
1010,
7,
9650
],
[
9650... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Mefloquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
],
[
"Pimozide",
... | Mefloquine may lead to a major life threatening interaction when taken with Pimozide and Pimozide may lead to a major life threatening interaction when taken with Astemizole
Mefloquine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Astemizole (Compound)
Mefloquine (Compound) upregulates HMGCS1 (Gene) and ... |
DB00069 | DB08870 | 367 | 850 | [
"DDInter946",
"DDInter228"
] | Interferon alfacon-1 | Brentuximab vedotin | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Moderate | 1 | [
[
[
367,
24,
850
]
],
[
[
367,
24,
788
],
[
788,
24,
850
]
],
[
[
367,
25,
1477
],
[
1477,
24,
850
]
],
[
[
367,
24,
1468
],
[
1468,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Pitavastatin and Pitavastatin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Interferon alfacon-1 may lead to a major life threatening interaction when taken with Tel... |
DB00945 | DB01050 | 1,479 | 848 | [
"DDInter20",
"DDInter900"
] | Acetylsalicylic acid | Ibuprofen | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Major | 2 | [
[
[
1479,
25,
848
]
],
[
[
1479,
6,
1829
],
[
1829,
45,
848
]
],
[
[
1479,
10,
11666
],
[
11666,
49,
848
]
],
[
[
1479,
54,
19122
],
[
191... | [
[
[
"Acetylsalicylic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibuprofen"
]
],
[
[
"Acetylsalicylic acid",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Acetylsalicylic acid (Compound) binds ALB (Gene) and ALB (Gene) is bound by Ibuprofen (Compound)
Acetylsalicylic acid (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is palliated by Ibuprofen (Compound)
Acetylsalicylic acid (Compound) is included by Nonsteroidal Anti-inflammatory Compounds (P... |
DB00264 | DB00424 | 88 | 19 | [
"DDInter1200",
"DDInter896"
] | Metoprolol | Hyoscyamine | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Moderate | 1 | [
[
[
88,
24,
19
]
],
[
[
88,
25,
1166
],
[
1166,
1,
19
]
],
[
[
88,
24,
85
],
[
85,
63,
19
]
],
[
[
88,
21,
29093
],
[
29093,
60,
... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Metoprolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dolasetron"
],
[
"Dolasetro... | Metoprolol may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compound) resembles Hyoscyamine (Compound)
Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseas... |
DB11627 | DB11834 | 1,367 | 1,303 | [
"DDInter860",
"DDInter849"
] | Hepatitis B Vaccine (Recombinant) | Guselkumab | Hepatitis B Vaccine is an ingredient in the EMA-withdrawn product Quintanrix. It is marketed in Canada as Engerix B. It is also a part of Twinrix (Hep A/Hep B vaccine) available also in Canada. The hepatitis B virus induces a severe form of viral hepatitis. Other causative agents are hepatitis A virus, and the non-A, n... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
1367,
24,
1303
]
],
[
[
1367,
63,
713
],
[
713,
24,
1303
]
],
[
[
1367,
24,
270
],
[
270,
63,
1303
]
],
[
[
1367,
63,
375
],
[
375,
... | [
[
[
"Hepatitis B Vaccine (Recombinant)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Hepatitis B Vaccine (Recombinant)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Hepatitis B Vaccine (Recombinant) may cause a moderate interaction that cou... |
DB00317 | DB05528 | 883 | 1,070 | [
"DDInter810",
"DDInter1228"
] | Gefitinib | Mipomersen | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
883,
25,
1070
]
],
[
[
883,
40,
1195
],
[
1195,
25,
1070
]
],
[
[
883,
1,
594
],
[
594,
64,
1070
]
],
[
[
883,
24,
1320
],
[
1320,
... | [
[
[
"Gefitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Gefitinib",
"{u} (Compound) resembles {v} (Compound)",
"Erlotinib"
],
[
"Erlotinib",
"{u} may lead to a major life threatening i... | Gefitinib (Compound) resembles Erlotinib (Compound) and Erlotinib may lead to a major life threatening interaction when taken with Mipomersen
Gefitinib (Compound) resembles Bosutinib (Compound) and Bosutinib may lead to a major life threatening interaction when taken with Mipomersen
Gefitinib may cause a moderate inter... |
DB01276 | DB11255 | 123 | 1,371 | [
"DDInter706",
"DDInter374"
] | Exenatide | Chromium picolinate | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are show... | Moderate | 1 | [
[
[
123,
24,
1371
]
],
[
[
123,
63,
245
],
[
245,
24,
1371
]
],
[
[
123,
24,
1296
],
[
1296,
24,
1371
]
],
[
[
123,
63,
245
],
[
245,
... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromium picolinate"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Chromium picolinate
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degl... |
DB00083 | DB00994 | 677 | 361 | [
"DDInter225",
"DDInter1277"
] | Botulinum toxin type A | Neomycin | In 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperf... | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Major | 2 | [
[
[
677,
25,
361
]
],
[
[
677,
25,
1132
],
[
1132,
24,
361
]
],
[
[
677,
25,
1448
],
[
1448,
63,
361
]
],
[
[
677,
25,
1481
],
[
1481,
... | [
[
[
"Botulinum toxin type A",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
]
],
[
[
"Botulinum toxin type A",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gentamicin"
],
[
"Gen... | Botulinum toxin type A may lead to a major life threatening interaction when taken with Gentamicin and Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Botulinum toxin type A may lead to a major life threatening interaction when taken with Streptomycin and Streptomycin... |
DB01044 | DB04272 | 246 | 442 | [
"DDInter809",
"DDInter390"
] | Gatifloxacin | Citric acid | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability. Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020. ... | Moderate | 1 | [
[
[
246,
24,
442
]
],
[
[
246,
40,
1176
],
[
1176,
24,
442
]
],
[
[
246,
1,
956
],
[
956,
24,
442
]
],
[
[
246,
24,
115
],
[
115,
64... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citric acid"
]
],
[
[
"Gatifloxacin",
"{u} (Compound) resembles {v} (Compound)",
"Moxifloxacin"
],
[
"Moxifloxacin",
"{u} may cause ... | Gatifloxacin (Compound) resembles Moxifloxacin (Compound) and Moxifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Citric acid
Gatifloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00055 | DB06081 | 834 | 1,046 | [
"DDInter605",
"DDInter286"
] | Drotrecogin alfa | Caplacizumab | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Caplacizumab, firstly called ALX-0081, is a humanized single-variable-domain immunoglobulin consisting of two identical humanized building blocks genetically linked by a three-alanine linker. Caplacizumab was developed by Ablynx, a Sanofi company and FDA approved on February 6, 2019, and approved previously by the EU i... | Major | 2 | [
[
[
834,
25,
1046
]
],
[
[
834,
23,
539
],
[
539,
62,
1046
]
],
[
[
834,
24,
1039
],
[
1039,
24,
1046
]
],
[
[
834,
25,
1171
],
[
1171,
... | [
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
]
],
[
[
"Drotrecogin alfa",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"... | Drotrecogin alfa may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Caplacizumab
Drotrecogin alfa may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine... |
DB00690 | DB11730 | 1,216 | 351 | [
"DDInter762",
"DDInter1588"
] | Flurazepam | Ribociclib | A benzodiazepine derivative used mainly as a hypnotic. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1216,
24,
351
]
],
[
[
1216,
24,
222
],
[
222,
23,
351
]
],
[
[
1216,
24,
283
],
[
283,
62,
351
]
],
[
[
1216,
24,
1532
],
[
1532,
... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
... | Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedrat... |
DB00413 | DB11186 | 1,346 | 1,609 | [
"DDInter1505",
"DDInter1427"
] | Pramipexole | Pentoxyverine | Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the mos... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
1346,
24,
1609
]
],
[
[
1346,
24,
104
],
[
104,
24,
1609
]
],
[
[
1346,
63,
999
],
[
999,
24,
1609
]
],
[
[
1346,
24,
104
],
[
104,
... | [
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Thiethylpera... |
DB00277 | DB01023 | 1,031 | 409 | [
"DDInter1791",
"DDInter716"
] | Theophylline | Felodipine | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Minor | 0 | [
[
[
1031,
23,
409
]
],
[
[
1031,
23,
336
],
[
336,
40,
409
]
],
[
[
1031,
23,
84
],
[
84,
1,
409
]
],
[
[
1031,
6,
3486
],
[
3486,
4... | [
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Felodipine"
]
],
[
[
"Theophylline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Nifedipine"
],
[
... | Theophylline may cause a minor interaction that can limit clinical effects when taken with Nifedipine and Nifedipine (Compound) resembles Felodipine (Compound)
Theophylline may cause a minor interaction that can limit clinical effects when taken with Nisoldipine and Nisoldipine (Compound) resembles Felodipine (Compound... |
DB00675 | DB06448 | 888 | 171 | [
"DDInter1744",
"DDInter1087"
] | Tamoxifen | Lonafarnib | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
888,
24,
171
]
],
[
[
888,
63,
254
],
[
254,
24,
171
]
],
[
[
888,
23,
112
],
[
112,
24,
171
]
],
[
[
888,
24,
850
],
[
850,
63,... | [
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitisinone"
],
[
... | Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Nitisinone and Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Tamoxifen may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metroni... |
DB00491 | DB01064 | 127 | 1,148 | [
"DDInter1217",
"DDInter987"
] | Miglitol | Isoprenaline | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
127,
24,
1148
]
],
[
[
127,
63,
1636
],
[
1636,
24,
1148
]
],
[
[
127,
24,
480
],
[
480,
24,
1148
]
],
[
[
127,
21,
28722
],
[
28722,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Fo... |
DB00570 | DB11003 | 147 | 748 | [
"DDInter1936",
"DDInter100"
] | Vinblastine | Anthrax vaccine | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
147,
24,
748
]
],
[
[
147,
63,
322
],
[
322,
24,
748
]
],
[
[
147,
23,
896
],
[
896,
24,
748
]
],
[
[
147,
24,
995
],
[
995,
24,... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Vinblastine may cause a minor interaction that can limit clinical effects when taken with Etoposide and Et... |
DB01211 | DB06699 | 609 | 774 | [
"DDInter393",
"DDInter493"
] | Clarithromycin | Degarelix | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Degarelix is used for the treatment of advanced prostate cancer. Degarelix is a synthetic peptide derivative drug which binds to gonadotropin-releasing hormone (GnRH) receptors in the pituitary gland and blocks interaction with GnRH. This antagonism reduces luteinising hormone (LH) and follicle-stimulating hormone (FSH... | Moderate | 1 | [
[
[
609,
24,
774
]
],
[
[
609,
63,
521
],
[
521,
1,
774
]
],
[
[
609,
21,
29232
],
[
29232,
60,
774
]
],
[
[
609,
62,
112
],
[
112,
... | [
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Degarelix"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Goserelin"
],
... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Goserelin (Compound) resembles Degarelix (Compound)
Clarithromycin (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Degarelix (Compound)
Clarithromycin may cause a minor interac... |
DB00026 | DB01284 | 1,184 | 1,042 | [
"DDInter94",
"DDInter1782"
] | Anakinra | Tetracosactide | Anakinra is a recombinant human interleukin-1 (IL-1) receptor antagonist (IL-1Ra) composed of 153 amino acid residues. Unlike native human IL-1Ra, anakinra has an additional methionine residue at the amino terminus. This drug binds to the IL-1 receptor, competing with and inhibiting the activity of IL-1 alpha and beta.... | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
1184,
24,
1042
]
],
[
[
1184,
24,
1683
],
[
1683,
63,
1042
]
],
[
[
1184,
25,
1137
],
[
1137,
63,
1042
]
],
[
[
1184,
24,
599
],
[
599... | [
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Anakinra",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ustekinumab"
],
[
... | Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Anakinra may lead to a major life threatening interaction when taken with Measles virus vaccine live attenua... |
DB00213 | DB08899 | 837 | 129 | [
"DDInter1388",
"DDInter649"
] | Pantoprazole | Enzalutamide | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
837,
24,
129
]
],
[
[
837,
6,
8374
],
[
8374,
45,
129
]
],
[
[
837,
21,
28703
],
[
28703,
60,
129
]
],
[
[
837,
63,
529
],
[
529,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Pantoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compo... | Pantoprazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Pantoprazole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine... |
DB00153 | DB00951 | 1,331 | 1,072 | [
"DDInter662",
"DDInter986"
] | Ergocalciferol | Isoniazid | Ergocalciferol is an inactivated vitamin D analog. It is synthesized by some plants in the presence of UVB light. The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolat... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
1331,
24,
1072
]
],
[
[
1331,
6,
8374
],
[
8374,
45,
1072
]
],
[
[
1331,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
1331,
36,
386
],
[
38... | [
[
[
"Ergocalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Ergocalciferol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Ergocalciferol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Isoniazid (Compound)
Ergocalciferol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Ergocalciferol (Compound) resembles Cholecalciferol (Compound) and Ergocalciferol may lead to a major life thr... |
DB01015 | DB01069 | 1,247 | 401 | [
"DDInter1724",
"DDInter1533"
] | Sulfamethoxazole | Promethazine | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Minor | 0 | [
[
[
1247,
23,
401
]
],
[
[
1247,
23,
1264
],
[
1264,
63,
401
]
],
[
[
1247,
6,
6017
],
[
6017,
45,
401
]
],
[
[
1247,
21,
28709
],
[
28709... | [
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Promethazine"
]
],
[
[
"Sulfamethoxazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doxepin"
],
... | Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Sulfamethoxazole (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Promethazine (Compound)
Sulfametho... |
DB01177 | DB08826 | 77 | 1,292 | [
"DDInter904",
"DDInter489"
] | Idarubicin | Deferiprone | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
77,
25,
1292
]
],
[
[
77,
18,
2215
],
[
2215,
57,
1292
]
],
[
[
77,
21,
28809
],
[
28809,
60,
1292
]
],
[
[
77,
63,
482
],
[
482,
... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Idarubicin",
"{u} (Compound) downregulates {v} (Gene)",
"HSPA8"
],
[
"HSPA8",
"{u} (Gene) is downregulated by {v} (Compound)",... | Idarubicin (Compound) downregulates HSPA8 (Gene) and HSPA8 (Gene) is downregulated by Deferiprone (Compound)
Idarubicin (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Deferiprone (Compound)
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Tio... |
DB00705 | DB06228 | 441 | 792 | [
"DDInter496",
"DDInter1609"
] | Delavirdine | Rivaroxaban | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
441,
24,
792
]
],
[
[
441,
6,
7524
],
[
7524,
45,
792
]
],
[
[
441,
21,
28703
],
[
28703,
60,
792
]
],
[
[
441,
63,
752
],
[
752,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Delavirdine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound... | Delavirdine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Rivaroxaban (Compound)
Delavirdine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and C... |
DB00213 | DB00798 | 837 | 1,132 | [
"DDInter1388",
"DDInter815"
] | Pantoprazole | Gentamicin | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
837,
24,
1132
]
],
[
[
837,
21,
28703
],
[
28703,
60,
1132
]
],
[
[
837,
24,
1252
],
[
1252,
23,
1132
]
],
[
[
837,
24,
361
],
[
361,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Pantoprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is ca... | Pantoprazole (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Gentamicin
Pa... |
DB00515 | DB10989 | 589 | 496 | [
"DDInter387",
"DDInter858"
] | Cisplatin | Hepatitis A Vaccine | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
589,
24,
496
]
],
[
[
589,
24,
4
],
[
4,
24,
496
]
],
[
[
589,
24,
738
],
[
738,
63,
496
]
],
[
[
589,
25,
976
],
[
976,
24,
... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesucc... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Cisplatin may cause a moderate interaction that could exacerbate diseases ... |
DB00877 | DB01406 | 629 | 984 | [
"DDInter1678",
"DDInter472"
] | Sirolimus | Danazol | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Moderate | 1 | [
[
[
629,
24,
984
]
],
[
[
629,
63,
989
],
[
989,
1,
984
]
],
[
[
629,
24,
35
],
[
35,
1,
984
]
],
[
[
629,
63,
1561
],
[
1561,
40,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Progesterone"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Progesterone and Progesterone (Compound) resembles Danazol (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Quinestrol and Quinestrol (Compound) resembles Danazol (Compound)
Siro... |
DB00334 | DB01261 | 867 | 170 | [
"DDInter1326",
"DDInter1679"
] | Olanzapine | Sitagliptin | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
867,
24,
170
]
],
[
[
867,
6,
8374
],
[
8374,
45,
170
]
],
[
[
867,
24,
52
],
[
52,
62,
170
]
],
[
[
867,
1,
623
],
[
623,
24,
... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Olanzapine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Olanzapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sitagliptin (Compound)
Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Olanzapine (Comp... |
DB00078 | DB01240 | 1,172 | 885 | [
"DDInter898",
"DDInter657"
] | Ibritumomab tiuxetan | Epoprostenol | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Major | 2 | [
[
[
1172,
25,
885
]
],
[
[
1172,
25,
1061
],
[
1061,
1,
885
]
],
[
[
1172,
23,
539
],
[
539,
62,
885
]
],
[
[
1172,
25,
1512
],
[
1512,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epoprostenol"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Treprostinil"
],
[
"T... | Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Ibritumomab tiuxetan may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can... |
DB08882 | DB14276 | 1,281 | 1,631 | [
"DDInter1070",
"DDInter1892"
] | Linagliptin | Turmeric | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Moderate | 1 | [
[
[
1281,
24,
1631
]
],
[
[
1281,
63,
473
],
[
473,
24,
1631
]
],
[
[
1281,
24,
1296
],
[
1296,
24,
1631
]
],
[
[
1281,
40,
1002
],
[
1002... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Turmeric"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
],
[
... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide and Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Turmeric
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec an... |
DB01233 | DB04896 | 1,311 | 901 | [
"DDInter1197",
"DDInter1220"
] | Metoclopramide | Milnacipran | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Moderate | 1 | [
[
[
1311,
24,
901
]
],
[
[
1311,
24,
41
],
[
41,
1,
901
]
],
[
[
1311,
63,
1349
],
[
1349,
40,
901
]
],
[
[
1311,
21,
28722
],
[
28722,
... | [
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Levomilnacipran and Levomilnacipran (Compound) resembles Milnacipran (Compound)
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Meperidine and Meperidine (Compound) resembles Mil... |
DB00106 | DB14509 | 618 | 1,399 | [
"DDInter4",
"DDInter1081"
] | Abarelix | Lithium carbonate | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
618,
24,
1399
]
],
[
[
618,
24,
1010
],
[
1010,
24,
1399
]
],
[
[
618,
23,
112
],
[
112,
24,
1399
]
],
[
[
618,
25,
877
],
[
877,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
],
[... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Lithium carbonate
Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Me... |
DB00106 | DB06595 | 618 | 1,491 | [
"DDInter4",
"DDInter1214"
] | Abarelix | Midostaurin | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Moderate | 1 | [
[
[
618,
24,
1491
]
],
[
[
618,
23,
112
],
[
112,
23,
1491
]
],
[
[
618,
24,
888
],
[
888,
24,
1491
]
],
[
[
618,
24,
657
],
[
657,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midostaurin"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Midostaurin
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxife... |
DB00539 | DB01319 | 11 | 34 | [
"DDInter1837",
"DDInter777"
] | Toremifene | Fosamprenavir | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Major | 2 | [
[
[
11,
25,
34
]
],
[
[
11,
25,
1091
],
[
1091,
40,
34
]
],
[
[
11,
6,
8374
],
[
8374,
45,
34
]
],
[
[
11,
21,
28723
],
[
28723,
60,... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
"Amprenavir",
"{u... | Toremifene may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Toremifene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Toremifene (Compound) causes Malnutrition (Side Effect) and Malnutrition (S... |
DB06290 | DB09065 | 1,449 | 760 | [
"DDInter1673",
"DDInter424"
] | Simeprevir | Cobicistat | Simeprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor indicated in patient's with HCV genotype 1 for the treatment of chronic hepatitis C virus (HCV) infection. HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, an... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
1449,
25,
760
]
],
[
[
1449,
64,
609
],
[
609,
24,
760
]
],
[
[
1449,
24,
466
],
[
466,
63,
760
]
],
[
[
1449,
63,
973
],
[
973,
... | [
[
[
"Simeprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Simeprevir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
[
"Clarithromycin",
... | Simeprevir may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Simeprevir may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamid... |
DB00407 | DB00775 | 202 | 1,226 | [
"DDInter115",
"DDInter1818"
] | Ardeparin | Tirofiban | Ardeparin, marketed under the US trade name Normiflo, is a low molecular weight heparin (LMWH) anticoagulant used for the prevention of postoperative venous thrombosis. Ardeparin is derived via peroxide degradation of heparin extracted from porcine intestinal mucosa. Its molecular weight ranges from 2000 to 15,000 with... | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Major | 2 | [
[
[
202,
25,
1226
]
],
[
[
202,
21,
28681
],
[
28681,
60,
1226
]
],
[
[
202,
25,
714
],
[
714,
63,
1226
]
],
[
[
202,
64,
1061
],
[
1061,
... | [
[
[
"Ardeparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tirofiban"
]
],
[
[
"Ardeparin",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) is caused b... | Ardeparin (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Tirofiban (Compound)
Ardeparin may lead to a major life threatening interaction when taken with Iloprost and Iloprost may cause a moderate interaction that could exacerbate diseases when taken with Tirofiban
Ardep... |
DB00402 | DB01246 | 1,407 | 820 | [
"DDInter685",
"DDInter45"
] | Eszopiclone | Alimemazine | Eszopiclone, marketed by Sepracor under the brand-name Lunesta, is a nonbenzodiazepine hypnotic drug used to treat insomnia. It is the active stereoisomer of zopiclone, belonging to the class of drugs known as _cyclopyrrolones_.[A179638,L6850] Cyclopyrrolone drugs demonstrate high efficacy and low toxicity, offering a ... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1407,
24,
820
]
],
[
[
1407,
24,
104
],
[
104,
40,
820
]
],
[
[
1407,
24,
401
],
[
401,
24,
820
]
],
[
[
1407,
24,
649
],
[
649,
... | [
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Eszopiclone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Eszopiclone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction... |
DB05812 | DB14723 | 1,374 | 159 | [
"DDInter8",
"DDInter1026"
] | Abiraterone | Larotrectinib | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Larotrectinib is an orally administered inhibitor of tropomyosin receptor kinase (Trk), a receptor tyrosine kinase activated by neurotrophins which is mutated in a variety of cancer cell types and plays an important role in tumor cell growth and survival. Upon administration, larotrectinib binds to Trk, thereby prevent... | Moderate | 1 | [
[
[
1374,
24,
159
]
],
[
[
1374,
23,
907
],
[
907,
23,
159
]
],
[
[
1374,
62,
479
],
[
479,
23,
159
]
],
[
[
1374,
64,
318
],
[
318,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Doravirine"
],
[... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine may cause a minor interaction that can limit clinical effects when taken with Larotrectinib
Abiraterone may cause a minor interaction that can limit clinical effects when taken with Donepezil and Donepezi... |
DB00451 | DB01406 | 542 | 984 | [
"DDInter1064",
"DDInter472"
] | Levothyroxine | Danazol | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Moderate | 1 | [
[
[
542,
24,
984
]
],
[
[
542,
24,
1546
],
[
1546,
1,
984
]
],
[
[
542,
24,
1026
],
[
1026,
40,
984
]
],
[
[
542,
6,
8374
],
[
8374,
... | [
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Danazol"
]
],
[
[
"Levothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyltestosterone"
... | Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Danazol (Compound)
Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxandrolone (Compound) resembles D... |
DB00283 | DB01069 | 701 | 401 | [
"DDInter395",
"DDInter1533"
] | Clemastine | Promethazine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
701,
24,
401
]
],
[
[
701,
24,
146
],
[
146,
24,
401
]
],
[
[
701,
24,
1264
],
[
1264,
63,
401
]
],
[
[
701,
1,
1460
],
[
1460,
... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
],
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Dox... |
DB00284 | DB14276 | 1,647 | 1,631 | [
"DDInter11",
"DDInter1892"
] | Acarbose | Turmeric | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Turmeric is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Moderate | 1 | [
[
[
1647,
24,
1631
]
],
[
[
1647,
23,
126
],
[
126,
23,
1631
]
],
[
[
1647,
23,
1645
],
[
1645,
24,
1631
]
],
[
[
1647,
24,
1021
],
[
1021... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Turmeric"
]
],
[
[
"Acarbose",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
],
[
"Warfa... | Acarbose may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfarin may cause a minor interaction that can limit clinical effects when taken with Turmeric
Acarbose may cause a minor interaction that can limit clinical effects when taken with Metformin and Metformin may cause a m... |
DB08865 | DB09020 | 1,593 | 28 | [
"DDInter448",
"DDInter212"
] | Crizotinib | Bisacodyl | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1593,
24,
28
]
],
[
[
1593,
7,
5998
],
[
5998,
46,
28
]
],
[
[
1593,
18,
4071
],
[
4071,
46,
28
]
],
[
[
1593,
18,
6004
],
[
6004,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Crizotinib",
"{u} (Compound) upregulates {v} (Gene)",
"HMOX1"
],
[
"HMOX1",
"{u} (Gene) is upregulated by {v} (Co... | Crizotinib (Compound) upregulates HMOX1 (Gene) and HMOX1 (Gene) is upregulated by Bisacodyl (Compound)
Crizotinib (Compound) downregulates PNP (Gene) and PNP (Gene) is upregulated by Bisacodyl (Compound)
Crizotinib (Compound) downregulates RFC4 (Gene) and RFC4 (Gene) is downregulated by Bisacodyl (Compound)
Crizotinib ... |
DB06777 | DB09381 | 780 | 192 | [
"DDInter348",
"DDInter678"
] | Chenodeoxycholic acid | Esterified estrogens | Chenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. It works by dissolving the cholesterol that makes gallstones and inhibiting production of cholesterol in the liver and absorption in the intestines, which helps to decre... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
780,
24,
192
]
],
[
[
780,
63,
126
],
[
126,
24,
192
]
],
[
[
780,
6,
8374
],
[
8374,
45,
752
],
[
752,
23,
192
]
],
[
[
780,
63... | [
[
[
"Chenodeoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Chenodeoxycholic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Chenodeoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Esterified estrogens
Chenodeoxycholic acid (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cimetidine (... |
DB01041 | DB01265 | 770 | 1,477 | [
"DDInter1789",
"DDInter1757"
] | Thalidomide | Telbivudine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Telbivudine is a synthetic thymidine nucleoside analog with specific activity against the hepatitis B virus. Telbivudine is orally administered, with good tolerance, lack of toxicity and no dose-limiting side effects. | Moderate | 1 | [
[
[
770,
24,
1477
]
],
[
[
770,
64,
141
],
[
141,
1,
1477
]
],
[
[
770,
63,
139
],
[
139,
1,
1477
]
],
[
[
770,
21,
28745
],
[
28745,
... | [
[
[
"Thalidomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telbivudine"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Floxuridine"
],
[
"Floxur... | Thalidomide may lead to a major life threatening interaction when taken with Floxuridine and Floxuridine (Compound) resembles Telbivudine (Compound)
Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine (Compound) resembles Telbivudine (Compound)
Thalidomi... |
DB12267 | DB13179 | 1,476 | 68 | [
"DDInter233",
"DDInter1882"
] | Brigatinib | Troleandomycin | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | A macrolide antibiotic that is similar to erythromycin. | Major | 2 | [
[
[
1476,
25,
68
]
],
[
[
1476,
63,
1601
],
[
1601,
23,
68
]
],
[
[
1476,
64,
1101
],
[
1101,
23,
68
]
],
[
[
1476,
24,
466
],
[
466,
... | [
[
[
"Brigatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Troleandomycin"
]
],
[
[
"Brigatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loratadine"
],
[
"Lorata... | Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Loratadine and Loratadine may cause a minor interaction that can limit clinical effects when taken with Troleandomycin
Brigatinib may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may caus... |
DB01165 | DB08899 | 1,539 | 129 | [
"DDInter1325",
"DDInter649"
] | Ofloxacin | Enzalutamide | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1539,
24,
129
]
],
[
[
1539,
63,
918
],
[
918,
1,
129
]
],
[
[
1539,
7,
5774
],
[
5774,
46,
129
]
],
[
[
1539,
21,
28703
],
[
28703,
... | [
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Ofloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
... | Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Ofloxacin (Compound) upregulates SELL (Gene) and SELL (Gene) is upregulated by Enzalutamide (Compound)
Ofloxacin (Compound) causes Pruritus (Side Effect) a... |
DB00013 | DB01404 | 1,255 | 757 | [
"DDInter1905",
"DDInter820"
] | Urokinase | Ginseng | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Ginseng is promoted as an adaptogen (a product that increases the body's resistance to stress), one which can to a certain extent be supported with reference to its anticarcinogenic and antioxidant properties. Ginseng is also known to contain phytoestrogens. | Moderate | 1 | [
[
[
1255,
24,
757
]
],
[
[
1255,
24,
578
],
[
578,
63,
757
]
],
[
[
1255,
25,
553
],
[
553,
24,
757
]
],
[
[
1255,
25,
256
],
[
256,
... | [
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginseng"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
"... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Ginseng
Urokinase may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a... |
DB00208 | DB00514 | 1,018 | 506 | [
"DDInter1804",
"DDInter527"
] | Ticlopidine | Dextromethorphan | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Moderate | 1 | [
[
[
1018,
24,
506
]
],
[
[
1018,
6,
8374
],
[
8374,
45,
506
]
],
[
[
1018,
21,
28810
],
[
28810,
60,
506
]
],
[
[
1018,
24,
311
],
[
311,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextromethorphan"
]
],
[
[
"Ticlopidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Ticlopidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dextromethorphan (Compound)
Ticlopidine (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Dextromethorphan (Compound)
Ticlopidine may cause a moderate interaction that could exacerbate disea... |
DB01156 | DB09122 | 593 | 1,613 | [
"DDInter252",
"DDInter1409"
] | Bupropion | Peginterferon beta-1a | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Major | 2 | [
[
[
593,
25,
1613
]
],
[
[
593,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
593,
25,
795
],
[
795,
24,
1613
]
],
[
[
593,
64,
1176
],
[
1176,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Bupropion",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
"... | Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Bupropion may lead to a major life threatening interaction when taken with Pemoline and Pemoline may... |
DB01583 | DB06723 | 624 | 115 | [
"DDInter1075",
"DDInter58"
] | Liotrix | Aluminum hydroxide | Liotrix is a synthetically derived thyroid hormone replacement preparation. It consists of levothyroxine sodium (thyroxine, T4) and liothyronine sodium (triiodothyronine, T3) in a 4 to 1 ratio by weight. Liotrix was developed when it was believed that serum levels of both T4 and T3 were maintained by direct thyroidal s... | Aluminum hydroxide is an inorganic salt used as an antacid. It is a basic compound that acts by neutralizing hydrochloric acid in gastric secretions. Subsequent increases in pH may inhibit the action of pepsin. An increase in bicarbonate ions and prostaglandins may also confer cytoprotective effects. | Moderate | 1 | [
[
[
624,
24,
115
]
],
[
[
624,
21,
29803
],
[
29803,
60,
115
]
],
[
[
624,
24,
428
],
[
428,
63,
115
]
],
[
[
624,
63,
1411
],
[
1411,
... | [
[
[
"Liotrix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
]
],
[
[
"Liotrix",
"{u} (Compound) causes {v} (Side Effect)",
"Venous thrombosis"
],
[
"Venous thrombosis",
"{u} (Si... | Liotrix (Compound) causes Venous thrombosis (Side Effect) and Venous thrombosis (Side Effect) is caused by Aluminum hydroxide (Compound)
Liotrix may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate di... |
DB00502 | DB11901 | 1,300 | 913 | [
"DDInter853",
"DDInter107"
] | Haloperidol | Apalutamide | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1300,
25,
913
]
],
[
[
1300,
23,
112
],
[
112,
23,
913
]
],
[
[
1300,
64,
600
],
[
600,
24,
913
]
],
[
[
1300,
24,
28
],
[
28,
2... | [
[
[
"Haloperidol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Haloperidol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Haloperidol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Haloperidol may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may... |
DB00307 | DB01244 | 1,101 | 762 | [
"DDInter202",
"DDInter192"
] | Bexarotene | Bepridil | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Moderate | 1 | [
[
[
1101,
24,
762
]
],
[
[
1101,
24,
704
],
[
704,
1,
762
]
],
[
[
1101,
21,
28698
],
[
28698,
60,
762
]
],
[
[
1101,
24,
1135
],
[
1135,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Bepridil (Compound)
Bexarotene (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Bepridil (Compound)
Bexarotene may cause a moderate interaction that could... |
DB01255 | DB08871 | 633 | 36 | [
"DDInter1078",
"DDInter666"
] | Lisdexamfetamine | Eribulin | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
633,
24,
36
]
],
[
[
633,
63,
1424
],
[
1424,
24,
36
]
],
[
[
633,
24,
28
],
[
28,
63,
36
]
],
[
[
633,
24,
774
],
[
774,
24,
... | [
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Lisdexamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinine"
],
... | Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Lisdexamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bis... |
DB00439 | DB06210 | 289 | 72 | [
"DDInter341",
"DDInter631"
] | Cerivastatin | Eltrombopag | On August 8, 2001 the U.S. Food and Drug Administration (FDA) announced that Bayer Pharmaceutical Division voluntarily withdrew Baycol from the U.S. market, due to reports of fatal rhabdomyolysis, a severe adverse reaction from this cholesterol-lowering (lipid-lowering) product. It has also been withdrawn from the Cana... | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
289,
24,
72
]
],
[
[
289,
24,
384
],
[
384,
63,
72
]
],
[
[
289,
24,
467
],
[
467,
24,
72
]
],
[
[
289,
63,
1560
],
[
1560,
24,
... | [
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Cerivastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
],
... | Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Cerivastatin may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and ... |
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