drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00254 | DB00855 | 964 | 213 | [
"DDInter598",
"DDInter72"
] | Doxycycline | Aminolevulinic acid | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Major | 2 | [
[
[
964,
25,
213
]
],
[
[
964,
23,
1577
],
[
1577,
25,
213
]
],
[
[
964,
23,
504
],
[
504,
64,
213
]
],
[
[
964,
1,
1572
],
[
1572,
... | [
[
[
"Doxycycline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aminolevulinic acid"
]
],
[
[
"Doxycycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydroflumethiazide"
],
[
... | Doxycycline may cause a minor interaction that can limit clinical effects when taken with Hydroflumethiazide and Hydroflumethiazide may lead to a major life threatening interaction when taken with Aminolevulinic acid
Doxycycline may cause a minor interaction that can limit clinical effects when taken with Hydrochloroth... |
DB00637 | DB06636 | 1,557 | 1,623 | [
"DDInter128",
"DDInter980"
] | Astemizole | Isavuconazonium | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1557,
24,
1623
]
],
[
[
1557,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
1557,
25,
1487
],
[
1487,
24,
1623
]
],
[
[
1557,
24,
1213
],
[
12... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Astemizole may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychlor... |
DB00314 | DB00448 | 894 | 1,215 | [
"DDInter288",
"DDInter1022"
] | Capreomycin | Lansoprazole | Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus. | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Moderate | 1 | [
[
[
894,
24,
1215
]
],
[
[
894,
24,
379
],
[
379,
1,
1215
]
],
[
[
894,
63,
837
],
[
837,
1,
1215
]
],
[
[
894,
21,
28882
],
[
28882,
... | [
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
]
],
[
[
"Capreomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
],
... | Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Rabeprazole and Rabeprazole (Compound) resembles Lansoprazole (Compound)
Capreomycin may cause a moderate interaction that could exacerbate diseases when taken with Pantoprazole and Pantoprazole (Compound) resembles Lansoprazole... |
DB01105 | DB01576 | 222 | 93 | [
"DDInter1665",
"DDInter526"
] | Sibutramine | Dextroamphetamine | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Dextroamphetamine is the dextrorotatory enantiomer of amphetamine. Dextroamphetamine was approved by the FDA in 2001 for the treatment of attention deficit hyperactivity disorder[L6010,Label]. | Major | 2 | [
[
[
222,
25,
93
]
],
[
[
222,
64,
73
],
[
73,
1,
93
]
],
[
[
222,
64,
80
],
[
80,
40,
93
]
],
[
[
222,
24,
94
],
[
94,
1,
93
... | [
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dextroamphetamine"
]
],
[
[
"Sibutramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phentermine"
],
[
"Phentermine",
... | Sibutramine may lead to a major life threatening interaction when taken with Phentermine and Phentermine (Compound) resembles Dextroamphetamine (Compound)
Sibutramine may lead to a major life threatening interaction when taken with Amphetamine and Amphetamine (Compound) resembles Dextroamphetamine (Compound)
Sibutramin... |
DB00598 | DB11093 | 1,523 | 636 | [
"DDInter1013",
"DDInter273"
] | Labetalol | Calcium citrate | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1523,
24,
636
]
],
[
[
1523,
62,
542
],
[
542,
24,
636
]
],
[
[
1523,
23,
115
],
[
115,
25,
636
]
],
[
[
1523,
62,
542
],
[
542,
... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Labetalol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Levothyroxine"
],
... | Labetalol may cause a minor interaction that can limit clinical effects when taken with Levothyroxine and Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Labetalol may cause a minor interaction that can limit clinical effects when taken with Aluminum hydroxi... |
DB00816 | DB01067 | 1,674 | 959 | [
"DDInter1346",
"DDInter826"
] | Orciprenaline | Glipizide | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1674,
24,
959
]
],
[
[
1674,
63,
245
],
[
245,
40,
959
]
],
[
[
1674,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1674,
21,
28987
],
[
28987,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Co... |
DB00704 | DB11767 | 267 | 1,583 | [
"DDInter1263",
"DDInter1643"
] | Naltrexone | Sarilumab | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Sarilumab is a fully human anti-interleukin 6 (IL-6) receptor monoclonal IgG1 antibody that binds to both membrane-bound and soluble IL-6 receptor forms, thus blocking the cis- and trans-inflammatory signalling cascades of IL-6. Sarilumab was developed by Sanofi and Regeneron Pharmaceuticals, Inc; it was US FDA-approve... | Moderate | 1 | [
[
[
267,
24,
1583
]
],
[
[
267,
63,
362
],
[
362,
24,
1583
]
],
[
[
267,
24,
850
],
[
850,
24,
1583
]
],
[
[
267,
24,
287
],
[
287,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarilumab"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Sarilumab
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and ... |
DB01365 | DB09045 | 280 | 52 | [
"DDInter1151",
"DDInter607"
] | Mephentermine | Dulaglutide | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
280,
24,
52
]
],
[
[
280,
63,
170
],
[
170,
23,
52
]
],
[
[
280,
74,
73
],
[
73,
24,
52
]
],
[
[
280,
63,
1152
],
[
1152,
24,
... | [
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Mephentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Mephentermine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Mephentermine (Compound) resembles Phentermine (Compound) and Mephentermine may cause a moderate interaction... |
DB04908 | DB09291 | 1,671 | 741 | [
"DDInter741",
"DDInter1615"
] | Flibanserin | Rolapitant | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1671,
24,
741
]
],
[
[
1671,
23,
1135
],
[
1135,
23,
741
]
],
[
[
1671,
63,
506
],
[
506,
24,
741
]
],
[
[
1671,
24,
159
],
[
159,
... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Flibanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Flibanserin may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Rolapitant
Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Dextromethorphan and Dext... |
DB11732 | DB12141 | 1,097 | 971 | [
"DDInter1027",
"DDInter817"
] | Lasmiditan | Gilteritinib | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
1097,
24,
971
]
],
[
[
1097,
63,
1135
],
[
1135,
23,
971
]
],
[
[
1097,
63,
72
],
[
72,
24,
971
]
],
[
[
1097,
24,
738
],
[
738,
... | [
[
[
"Lasmiditan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Lasmiditan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Lasmiditan may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Lasmiditan may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltromb... |
DB09052 | DB14730 | 250 | 1,412 | [
"DDInter220",
"DDInter264"
] | Blinatumomab | Calaspargase pegol | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
250,
24,
1412
]
],
[
[
250,
63,
322
],
[
322,
24,
1412
]
],
[
[
250,
64,
593
],
[
593,
24,
1412
]
],
[
[
250,
24,
384
],
[
384,
... | [
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
... | Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Blinatumomab may lead to a major life threatening interaction when taken with Bupropion and Bupropion ... |
DB00775 | DB10897 | 1,226 | 539 | [
"DDInter1818",
"DDInter291"
] | Tirofiban | Capsicum | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Capsicum (Chili pepper) allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
1226,
23,
539
]
],
[
[
1226,
24,
885
],
[
885,
23,
539
]
],
[
[
1226,
64,
702
],
[
702,
23,
539
]
],
[
[
1226,
63,
1061
],
[
1061,
... | [
[
[
"Tirofiban",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
]
],
[
[
"Tirofiban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Tirofiban may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum
Tirofiban may lead to a major life threatening interaction when taken with Anagrelide and Anagrelide may cause a ... |
DB01149 | DB09074 | 851 | 1,362 | [
"DDInter1274",
"DDInter1327"
] | Nefazodone | Olaparib | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
851,
25,
1362
]
],
[
[
851,
63,
896
],
[
896,
24,
1362
]
],
[
[
851,
25,
1478
],
[
1478,
24,
1362
]
],
[
[
851,
64,
467
],
[
467,
... | [
[
[
"Nefazodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Etoposide",
... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Nefazodone may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a mode... |
DB00015 | DB00374 | 582 | 1,061 | [
"DDInter1585",
"DDInter1852"
] | Reteplase | Treprostinil | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
582,
24,
1061
]
],
[
[
582,
24,
885
],
[
885,
40,
1061
]
],
[
[
582,
23,
539
],
[
539,
62,
1061
]
],
[
[
582,
24,
914
],
[
914,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Reteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit ... |
DB00563 | DB00861 | 663 | 914 | [
"DDInter1174",
"DDInter551"
] | Methotrexate | Diflunisal | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Major | 2 | [
[
[
663,
25,
914
]
],
[
[
663,
24,
712
],
[
712,
63,
914
]
],
[
[
663,
7,
7720
],
[
7720,
45,
914
]
],
[
[
663,
6,
10612
],
[
10612,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diflunisal"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
[
"Olsala... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal
Methotrexate (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Diflunisal (Compound)
Methotrexa... |
DB00719 | DB00836 | 1,219 | 543 | [
"DDInter149",
"DDInter1088"
] | Azatadine | Loperamide | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Moderate | 1 | [
[
[
1219,
24,
543
]
],
[
[
1219,
24,
704
],
[
704,
40,
543
]
],
[
[
1219,
64,
675
],
[
675,
24,
543
]
],
[
[
1219,
24,
262
],
[
262,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Loperamide (Compound)
Azatadine may lead to a major life threatening interaction when taken with Dextropropoxyphene and Dextropropoxyphene may cause a moderate interaction that could exac... |
DB01577 | DB08938 | 1,529 | 1,384 | [
"DDInter1161",
"DDInter1112"
] | Metamfetamine | Magaldrate | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
1529,
24,
1384
]
],
[
[
1529,
63,
401
],
[
401,
23,
1384
]
],
[
[
1529,
1,
633
],
[
633,
24,
1384
]
],
[
[
1529,
63,
245
],
[
245,
... | [
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Metamfetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Metamfetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Metamfetamine (Compound) resembles Lisdexamfetamine (Compound) and Lisdexamfetamine may cause a moderate in... |
DB00297 | DB14740 | 606 | 771 | [
"DDInter249",
"DDInter881"
] | Bupivacaine | Hyaluronidase | Bupivacaine is a widely used local anesthetic agent. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
606,
23,
771
]
],
[
[
606,
40,
815
],
[
815,
23,
771
]
],
[
[
606,
40,
815
],
[
815,
40,
608
],
[
608,
23,
771
]
],
[
[
606,
6,
... | [
[
[
"Bupivacaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Bupivacaine",
"{u} (Compound) resembles {v} (Compound)",
"Mepivacaine"
],
[
"Mepivacaine",
"{u} may cause a mi... | Bupivacaine (Compound) resembles Mepivacaine (Compound) and Mepivacaine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Bupivacaine (Compound) resembles Mepivacaine (Compound) and Mepivacaine (Compound) resembles Lidocaine (Compound) and Lidocaine may cause a minor interactio... |
DB00349 | DB01205 | 902 | 1,404 | [
"DDInter401",
"DDInter748"
] | Clobazam | Flumazenil | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Fumazenil is an imidazobenzodiazepine derivative and a potent benzodiazepine receptor antagonist that competitively inhibits the activity at the benzodiazepine recognition site on the GABA/benzodiazepine receptor complex, thereby reversing the effects of benzodiazepine on the central nervous system. | Moderate | 1 | [
[
[
902,
24,
1404
]
],
[
[
902,
6,
6506
],
[
6506,
45,
1404
]
],
[
[
902,
21,
29003
],
[
29003,
60,
1404
]
],
[
[
902,
40,
1382
],
[
1382,... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flumazenil"
]
],
[
[
"Clobazam",
"{u} (Compound) binds {v} (Gene)",
"GABRG2"
],
[
"GABRG2",
"{u} (Gene) is bound by {v} (Compound)",
... | Clobazam (Compound) binds GABRG2 (Gene) and GABRG2 (Gene) is bound by Flumazenil (Compound)
Clobazam (Compound) causes Aggression (Side Effect) and Aggression (Side Effect) is caused by Flumazenil (Compound)
Clobazam (Compound) resembles Midazolam (Compound) and Midazolam may cause a moderate interaction that could exa... |
DB00196 | DB08903 | 600 | 996 | [
"DDInter743",
"DDInter170"
] | Fluconazole | Bedaquiline | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
600,
25,
996
]
],
[
[
600,
6,
8374
],
[
8374,
45,
996
]
],
[
[
600,
21,
29267
],
[
29267,
60,
996
]
],
[
[
600,
23,
112
],
[
112,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Beda... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bedaquiline (Compound)
Fluconazole (Compound) causes Alanine aminotransferase increased (Side Effect) and Alanine aminotransferase increased (Side Effect) is caused by Bedaquiline (Compound)
Fluconazole may cause a minor interaction that can limit... |
DB04908 | DB09098 | 1,671 | 98 | [
"DDInter741",
"DDInter1700"
] | Flibanserin | Somatrem | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
1671,
24,
98
]
],
[
[
1671,
62,
168
],
[
168,
23,
98
]
],
[
[
1671,
24,
159
],
[
159,
63,
98
]
],
[
[
1671,
64,
609
],
[
609,
24... | [
[
[
"Flibanserin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Flibanserin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bortezomib"
],
[
... | Flibanserin may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Somatrem
Flibanserin may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotre... |
DB00618 | DB01357 | 1,572 | 890 | [
"DDInter498",
"DDInter1160"
] | Demeclocycline | Mestranol | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Moderate | 1 | [
[
[
1572,
24,
890
]
],
[
[
1572,
24,
126
],
[
126,
24,
890
]
],
[
[
1572,
1,
1545
],
[
1545,
24,
890
]
],
[
[
1572,
40,
964
],
[
964,
... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
],
... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Warfarin and Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Mestranol
Demeclocycline (Compound) resembles Oxytetracycline (Compound) and Oxytetracycline may cause a moderate interacti... |
DB00372 | DB01175 | 999 | 318 | [
"DDInter1793",
"DDInter672"
] | Thiethylperazine | Escitalopram | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Moderate | 1 | [
[
[
999,
24,
318
]
],
[
[
999,
63,
1230
],
[
1230,
1,
318
]
],
[
[
999,
24,
1419
],
[
1419,
23,
318
]
],
[
[
999,
63,
245
],
[
245,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a minor interaction tha... |
DB00252 | DB08938 | 362 | 1,384 | [
"DDInter1460",
"DDInter1112"
] | Phenytoin | Magaldrate | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Moderate | 1 | [
[
[
362,
24,
1384
]
],
[
[
362,
24,
167
],
[
167,
23,
1384
]
],
[
[
362,
25,
263
],
[
263,
23,
1384
]
],
[
[
362,
63,
1018
],
[
1018,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magaldrate"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Phenytoin may lead to a major life threatening interaction when taken with Axitinib and Axitinib may cause ... |
DB00005 | DB14409 | 1,057 | 1,129 | [
"DDInter687",
"DDInter867"
] | Etanercept | Human adenovirus e serotype 4 strain cl-68578 antigen | Dimeric fusion protein consisting of the extracellular ligand-binding portion of the human 75 kilodalton (p75) tumor necrosis factor receptor (TNFR) linked to the Fc portion of human IgG1.[L14862,A216522] The Fc component of etanercept contains the CH2 domain, the CH3 domain and hinge region, but not the CH1 domain of ... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1057,
24,
1129
]
],
[
[
1057,
25,
1683
],
[
1683,
24,
1129
]
],
[
[
1057,
25,
676
],
[
676,
63,
1129
]
],
[
[
1057,
24,
599
],
[
599,
... | [
[
[
"Etanercept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Etanercept",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Etanercept may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Etanercept may lead to a major life threatening interaction when taken with Upadac... |
DB00999 | DB01164 | 504 | 803 | [
"DDInter883",
"DDInter272"
] | Hydrochlorothiazide | Calcium chloride | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in ... | Moderate | 1 | [
[
[
504,
24,
803
]
],
[
[
504,
21,
29196
],
[
29196,
60,
803
]
],
[
[
504,
62,
1545
],
[
1545,
24,
803
]
],
[
[
504,
1,
1577
],
[
1577,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium chloride"
]
],
[
[
"Hydrochlorothiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
... | Hydrochlorothiazide (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Calcium chloride (Compound)
Hydrochlorothiazide may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline and Oxytetracycline may cause a moderate interaction that could exace... |
DB00104 | DB12825 | 966 | 1,375 | [
"DDInter1323",
"DDInter1032"
] | Octreotide | Lefamulin | Acromegaly is a disorder caused by excess growth hormone (GH), increasing the growth of body tissues and causing metabolic dysfunction. In most cases, it results from an anterior pituitary growth hormone-releasing tumor. Typically, the feet, hands, and face grow abnormally large; organomegaly and insulin resistance may... | Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus. Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August... | Moderate | 1 | [
[
[
966,
24,
1375
]
],
[
[
966,
24,
159
],
[
159,
63,
1375
]
],
[
[
966,
25,
1101
],
[
1101,
24,
1375
]
],
[
[
966,
24,
1324
],
[
1324,
... | [
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lefamulin"
]
],
[
[
"Octreotide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[
... | Octreotide may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lefamulin
Octreotide may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may c... |
DB01128 | DB08864 | 918 | 786 | [
"DDInter204",
"DDInter1595"
] | Bicalutamide | Rilpivirine | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
918,
24,
786
]
],
[
[
918,
6,
8374
],
[
8374,
45,
786
]
],
[
[
918,
21,
29343
],
[
29343,
60,
786
]
],
[
[
918,
62,
112
],
[
112,
... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Bicalutamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Bicalutamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Bicalutamide (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Rilpivirine (Compound)
Bicalutamide may cause a minor interaction that can limit clinical eff... |
DB01452 | DB01612 | 993 | 1,637 | [
"DDInter532",
"DDInter92"
] | Diamorphine | Amyl Nitrite | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
993,
24,
1637
]
],
[
[
993,
64,
475
],
[
475,
24,
1637
]
],
[
[
993,
63,
401
],
[
401,
24,
1637
]
],
[
[
993,
24,
407
],
[
407,
... | [
[
[
"Diamorphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Diamorphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Morphine"
],
[
"Morphine... | Diamorphine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Diamorphine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may ca... |
DB00431 | DB00760 | 1,503 | 1,584 | [
"DDInter1072",
"DDInter1157"
] | Lindane | Meropenem | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. In August 2017, a combination antibacterial ... | Moderate | 1 | [
[
[
1503,
24,
1584
]
],
[
[
1503,
21,
28762
],
[
28762,
60,
1584
]
],
[
[
1503,
24,
1383
],
[
1383,
63,
1584
]
],
[
[
1503,
25,
497
],
[
4... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meropenem"
]
],
[
[
"Lindane",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v}... | Lindane (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Meropenem (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate and Sodium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Meropene... |
DB01177 | DB11817 | 77 | 1,259 | [
"DDInter904",
"DDInter165"
] | Idarubicin | Baricitinib | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
77,
25,
1259
]
],
[
[
77,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
77,
24,
949
],
[
949,
24,
1259
]
],
[
[
77,
63,
563
],
[
563,
24... | [
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Idarubicin may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoi... |
DB00688 | DB00787 | 955 | 387 | [
"DDInter1251",
"DDInter25"
] | Mycophenolate mofetil | Acyclovir | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young a... | Minor | 0 | [
[
[
955,
23,
387
]
],
[
[
955,
18,
6898
],
[
6898,
46,
387
]
],
[
[
955,
7,
20027
],
[
20027,
57,
387
]
],
[
[
955,
18,
2183
],
[
2183,
... | [
[
[
"Mycophenolate mofetil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acyclovir"
]
],
[
[
"Mycophenolate mofetil",
"{u} (Compound) downregulates {v} (Gene)",
"DFFB"
],
[
"DFFB",
"{u} (Gene) is up... | Mycophenolate mofetil (Compound) downregulates DFFB (Gene) and DFFB (Gene) is upregulated by Acyclovir (Compound)
Mycophenolate mofetil (Compound) upregulates LRP10 (Gene) and LRP10 (Gene) is downregulated by Acyclovir (Compound)
Mycophenolate mofetil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregula... |
DB06209 | DB14357 | 256 | 944 | [
"DDInter1508",
"DDInter347"
] | Prasugrel | Chamomile | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Chamomile is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug. | Minor | 0 | [
[
[
256,
23,
944
]
],
[
[
256,
64,
582
],
[
582,
23,
944
]
],
[
[
256,
25,
792
],
[
792,
23,
944
]
],
[
[
256,
63,
1061
],
[
1061,
2... | [
[
[
"Prasugrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
]
],
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Reteplase"
],
[
"Reteplase",
... | Prasugrel may lead to a major life threatening interaction when taken with Reteplase and Reteplase may cause a minor interaction that can limit clinical effects when taken with Chamomile
Prasugrel may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a minor interaction ... |
DB00708 | DB01176 | 1,454 | 537 | [
"DDInter1718",
"DDInter453"
] | Sufentanil | Cyclizine | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1454,
24,
537
]
],
[
[
1454,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1454,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1454,
24,
104
],
[
104,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
[
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetir... |
DB00816 | DB00988 | 1,674 | 817 | [
"DDInter1346",
"DDInter584"
] | Orciprenaline | Dopamine | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Moderate | 1 | [
[
[
1674,
24,
817
]
],
[
[
1674,
24,
532
],
[
532,
1,
817
]
],
[
[
1674,
35,
1148
],
[
1148,
63,
817
]
],
[
[
1674,
1,
693
],
[
693,
... | [
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dopamine"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dobutamine"
],
... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Dobutamine and Dobutamine (Compound) resembles Dopamine (Compound)
Orciprenaline (Compound) resembles Isoprenaline (Compound) and Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Is... |
DB05679 | DB14409 | 1,683 | 1,129 | [
"DDInter1907",
"DDInter867"
] | Ustekinumab | Human adenovirus e serotype 4 strain cl-68578 antigen | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
1683,
24,
1129
]
],
[
[
1683,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
1683,
63,
134
],
[
134,
24,
1129
]
],
[
[
1683,
24,
1456
],
[
1456... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Ustekinumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Ustekinumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Ustekinumab may cause a moderate interaction that could exacerbate diseases when ta... |
DB00013 | DB11703 | 1,255 | 405 | [
"DDInter1905",
"DDInter9"
] | Urokinase | Acalabrutinib | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
1255,
25,
405
]
],
[
[
1255,
24,
383
],
[
383,
24,
405
]
],
[
[
1255,
24,
738
],
[
738,
63,
405
]
],
[
[
1255,
25,
126
],
[
126,
... | [
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Urokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentosan polysulfate"
],
[
... | Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Pentosan polysulfate and Pentosan polysulfate may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00400 | DB01253 | 353 | 628 | [
"DDInter843",
"DDInter664"
] | Griseofulvin | Ergometrine | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | An ergot alkaloid with uterine and vascular smooth muscle contractile properties. | Moderate | 1 | [
[
[
353,
24,
628
]
],
[
[
353,
63,
1131
],
[
1131,
40,
628
]
],
[
[
353,
24,
826
],
[
826,
40,
628
]
],
[
[
353,
6,
8374
],
[
8374,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ergometrine"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methysergide"
],
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Methysergide and Methysergide (Compound) resembles Ergometrine (Compound)
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Ergotamine and Ergotamine (Compound) resembles Ergometrine (... |
DB00211 | DB01069 | 1,290 | 401 | [
"DDInter1213",
"DDInter1533"
] | Midodrine | Promethazine | An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1290,
24,
401
]
],
[
[
1290,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1290,
6,
12523
],
[
12523,
45,
401
]
],
[
[
1290,
21,
28787
],
[
287... | [
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Midodrine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Promethazine (Compound)
Midodrine (Compound) c... |
DB00252 | DB01058 | 362 | 978 | [
"DDInter1460",
"DDInter1510"
] | Phenytoin | Praziquantel | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Praziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis. The efficacy of praziquantel in treating parasitic flatworms infecti... | Major | 2 | [
[
[
362,
25,
978
]
],
[
[
362,
6,
7524
],
[
7524,
45,
978
]
],
[
[
362,
21,
28709
],
[
28709,
60,
978
]
],
[
[
362,
25,
752
],
[
752,
... | [
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Praziquantel"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",
"Praziqu... | Phenytoin (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Praziquantel (Compound)
Phenytoin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Praziquantel (Compound)
Phenytoin may lead to a major life threatening interaction when taken with Cimetidine and ... |
DB00912 | DB01115 | 473 | 336 | [
"DDInter1581",
"DDInter1291"
] | Repaglinide | Nifedipine | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Moderate | 1 | [
[
[
473,
24,
336
]
],
[
[
473,
6,
8374
],
[
8374,
45,
336
]
],
[
[
473,
21,
29119
],
[
29119,
60,
336
]
],
[
[
473,
24,
466
],
[
466,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nifedipine"
]
],
[
[
"Repaglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Repaglinide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nifedipine (Compound)
Repaglinide (Compound) causes Haemolytic anaemia (Side Effect) and Haemolytic anaemia (Side Effect) is caused by Nifedipine (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00682 | DB01406 | 126 | 984 | [
"DDInter1951",
"DDInter472"
] | Warfarin | Danazol | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Major | 2 | [
[
[
126,
25,
984
]
],
[
[
126,
25,
1546
],
[
1546,
1,
984
]
],
[
[
126,
63,
1573
],
[
1573,
1,
984
]
],
[
[
126,
24,
167
],
[
167,
1... | [
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danazol"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methyltestosterone"
],
[
"Methyltestosterone",
... | Warfarin may lead to a major life threatening interaction when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Danazol (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Danazol (Compound)
Warfarin ... |
DB00208 | DB00215 | 1,018 | 1,230 | [
"DDInter1804",
"DDInter388"
] | Ticlopidine | Citalopram | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Major | 2 | [
[
[
1018,
25,
1230
]
],
[
[
1018,
24,
318
],
[
318,
40,
1230
]
],
[
[
1018,
6,
7950
],
[
7950,
45,
1230
]
],
[
[
1018,
21,
29076
],
[
2907... | [
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
]
],
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Escitalopram"
],
[
"Escita... | Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram (Compound) resembles Citalopram (Compound)
Ticlopidine (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Citalopram (Compound)
Ticlopidine (Compound) causes Liver function test abnormal (... |
DB00529 | DB01041 | 789 | 770 | [
"DDInter779",
"DDInter1789"
] | Foscarnet | Thalidomide | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
789,
24,
770
]
],
[
[
789,
21,
28784
],
[
28784,
60,
770
]
],
[
[
789,
24,
609
],
[
609,
63,
770
]
],
[
[
789,
24,
1557
],
[
1557,
... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Thrombocytopenia"
],
[
"Thrombocytopenia",
"{u} (Side Ef... | Foscarnet (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Thalidomide (Compound)
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases wh... |
DB00448 | DB15093 | 1,215 | 1,654 | [
"DDInter1022",
"DDInter1698"
] | Lansoprazole | Somapacitan | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1215,
24,
1654
]
],
[
[
1215,
63,
883
],
[
883,
24,
1654
]
],
[
[
1215,
24,
467
],
[
467,
24,
1654
]
],
[
[
1215,
25,
1250
],
[
1250,
... | [
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Lansoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
... | Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Lansoprazole may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Si... |
DB00278 | DB06206 | 291 | 1,268 | [
"DDInter117",
"DDInter1719"
] | Argatroban | Sugammadex | Argatroban is a direct, selective thrombin inhibitor. The American College of Cardiologists (ACC) recommend using bivalirudin or argatroban in patients who have had, or at risk for, heparin induced thrombocytopenia (HIT) and are undergoing percutaneous coronary intervention. Argatroban is a non-heparin anticoagulant sh... | Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general ane... | Moderate | 1 | [
[
[
291,
24,
1268
]
],
[
[
291,
25,
279
],
[
279,
24,
1268
]
],
[
[
291,
25,
1409
],
[
1409,
63,
1268
]
],
[
[
291,
64,
942
],
[
942,
... | [
[
[
"Argatroban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sugammadex"
]
],
[
[
"Argatroban",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
],
[
"Anisindio... | Argatroban may lead to a major life threatening interaction when taken with Anisindione and Anisindione may cause a moderate interaction that could exacerbate diseases when taken with Sugammadex
Argatroban may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate intera... |
DB00762 | DB01004 | 613 | 563 | [
"DDInter973",
"DDInter806"
] | Irinotecan | Ganciclovir | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. | Moderate | 1 | [
[
[
613,
24,
563
]
],
[
[
613,
24,
248
],
[
248,
40,
563
]
],
[
[
613,
18,
1917
],
[
1917,
57,
563
]
],
[
[
613,
21,
29327
],
[
29327,
... | [
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
]
],
[
[
"Irinotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
],
... | Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Valganciclovir and Valganciclovir (Compound) resembles Ganciclovir (Compound)
Irinotecan (Compound) downregulates CDC25B (Gene) and CDC25B (Gene) is downregulated by Ganciclovir (Compound)
Irinotecan (Compound) causes Renal failu... |
DB09079 | DB09291 | 1,496 | 741 | [
"DDInter1296",
"DDInter1615"
] | Nintedanib | Rolapitant | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its l... | Moderate | 1 | [
[
[
1496,
24,
741
]
],
[
[
1496,
24,
159
],
[
159,
63,
741
]
],
[
[
1496,
63,
1671
],
[
1671,
24,
741
]
],
[
[
1496,
64,
1510
],
[
1510,
... | [
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rolapitant"
]
],
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[... | Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Rolapitant
Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Flibanserin and... |
DB00679 | DB01041 | 684 | 770 | [
"DDInter1796",
"DDInter1789"
] | Thioridazine | Thalidomide | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
684,
24,
770
]
],
[
[
684,
6,
6365
],
[
6365,
45,
770
]
],
[
[
684,
7,
7669
],
[
7669,
46,
770
]
],
[
[
684,
18,
3106
],
[
3106,
... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Thioridazine",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compou... | Thioridazine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Thioridazine (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Thioridazine (Compound) downregulates DNAJA3 (Gene) and DNAJA3 (Gene) is downregulated by Thalidomide (Compound)
Thi... |
DB00224 | DB01268 | 215 | 1,151 | [
"DDInter917",
"DDInter1731"
] | Indinavir | Sunitinib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
215,
24,
1151
]
],
[
[
215,
18,
2284
],
[
2284,
45,
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],
[
[
215,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
215,
18,
8386
],
[
8386,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Indinavir",
"{u} (Compound) downregulates {v} (Gene)",
"PRPF4"
],
[
"PRPF4",
"{u} (Gene) is bound by {v} (Compound... | Indinavir (Compound) downregulates PRPF4 (Gene) and PRPF4 (Gene) is bound by Sunitinib (Compound)
Indinavir (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Indinavir (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by Sunitinib (Compound)
Indinavir (Compound) downr... |
DB00208 | DB10672 | 1,018 | 297 | [
"DDInter1804",
"DDInter417"
] | Ticlopidine | Clove | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
1018,
23,
297
]
],
[
[
1018,
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],
[
235,
62,
297
]
],
[
[
1018,
24,
578
],
[
578,
23,
297
]
],
[
[
1018,
25,
1564
],
[
1564,
... | [
[
[
"Ticlopidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Ticlopidine may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor... |
DB00197 | DB11703 | 1,324 | 405 | [
"DDInter1881",
"DDInter9"
] | Troglitazone | Acalabrutinib | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Moderate | 1 | [
[
[
1324,
24,
405
]
],
[
[
1324,
23,
1101
],
[
1101,
24,
405
]
],
[
[
1324,
24,
1446
],
[
1446,
24,
405
]
],
[
[
1324,
24,
1598
],
[
1598,... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Troglitazone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bexarotene"
],
... | Troglitazone may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Lanreotide and L... |
DB01181 | DB15965 | 1,532 | 1,330 | [
"DDInter906",
"DDInter1270"
] | Ifosfamide | Naxitamab | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
1532,
24,
1330
]
],
[
[
1532,
63,
597
],
[
597,
24,
1330
]
],
[
[
1532,
24,
259
],
[
259,
24,
1330
]
],
[
[
1532,
64,
770
],
[
770,
... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
... | Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept a... |
DB09268 | DB12332 | 1,662 | 1,619 | [
"DDInter1464",
"DDInter1626"
] | Picosulfuric acid | Rucaparib | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1662,
24,
1619
]
],
[
[
1662,
63,
222
],
[
222,
23,
1619
]
],
[
[
1662,
63,
154
],
[
154,
24,
1619
]
],
[
[
1662,
24,
1019
],
[
1019,
... | [
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
... | Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Lurasido... |
DB00361 | DB08913 | 134 | 1,186 | [
"DDInter1939",
"DDInter1561"
] | Vinorelbine | Radium Ra 223 dichloride | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first ap... | Moderate | 1 | [
[
[
134,
24,
1186
]
],
[
[
134,
21,
28872
],
[
28872,
60,
1186
]
],
[
[
134,
24,
37
],
[
37,
24,
1186
]
],
[
[
134,
24,
1583
],
[
1583,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Radium Ra 223 dichloride"
]
],
[
[
"Vinorelbine",
"{u} (Compound) causes {v} (Side Effect)",
"Extravasation"
],
[
"Extravasation",
"{... | Vinorelbine (Compound) causes Extravasation (Side Effect) and Extravasation (Side Effect) is caused by Radium Ra 223 dichloride (Compound)
Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Lomustine and Lomustine may cause a moderate interaction that could exacerbate diseases w... |
DB00222 | DB08820 | 245 | 1,478 | [
"DDInter825",
"DDInter997"
] | Glimepiride | Ivacaftor | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
245,
24,
1478
]
],
[
[
245,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
245,
24,
318
],
[
318,
23,
1478
]
],
[
[
245,
63,
1230
],
[
1230,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is cause... | Glimepiride (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Ivacaf... |
DB01224 | DB11186 | 623 | 1,609 | [
"DDInter1553",
"DDInter1427"
] | Quetiapine | Pentoxyverine | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
623,
24,
1609
]
],
[
[
623,
40,
508
],
[
508,
24,
1609
]
],
[
[
623,
74,
104
],
[
104,
24,
1609
]
],
[
[
623,
63,
999
],
[
999,
... | [
[
[
"Quetiapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Quetiapine",
"{u} (Compound) resembles {v} (Compound)",
"Promazine"
],
[
"Promazine",
"{u} may cause a modera... | Quetiapine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Quetiapine (Compound) resembles Methdilazine (Compound) and Quetiapine may cause a moderate interaction that could exacerbate diseases when taken with Methdila... |
DB00658 | DB01024 | 965 | 1,096 | [
"DDInter1663",
"DDInter1252"
] | Sevelamer | Mycophenolic acid | Sevelamer is a phosphate binding drug used to prevent hyperphosphataemia in patients with chronic renal failure. It is marketed by Genzyme under the trade name Renagel. | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Moderate | 1 | [
[
[
965,
24,
1096
]
],
[
[
965,
24,
955
],
[
955,
1,
1096
]
],
[
[
965,
21,
29954
],
[
29954,
60,
1096
]
],
[
[
965,
63,
1461
],
[
1461,
... | [
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic acid"
]
],
[
[
"Sevelamer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofetil"... | Sevelamer may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolate mofetil and Mycophenolate mofetil (Compound) resembles Mycophenolic acid (Compound)
Sevelamer (Compound) causes Intestinal perforation (Side Effect) and Intestinal perforation (Side Effect) is caused by Mycophenolic ... |
DB01128 | DB06702 | 918 | 573 | [
"DDInter204",
"DDInter731"
] | Bicalutamide | Fesoterodine | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Fesoterodine is an antimuscarinic prodrug for the treatment of overactive bladder syndrome. | Moderate | 1 | [
[
[
918,
24,
573
]
],
[
[
918,
63,
211
],
[
211,
1,
573
]
],
[
[
918,
64,
494
],
[
494,
1,
573
]
],
[
[
918,
6,
12523
],
[
12523,
45... | [
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fesoterodine"
]
],
[
[
"Bicalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolterodine"
],
... | Bicalutamide may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Fesoterodine (Compound)
Bicalutamide may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide (Compound) resembles Fesoterodine (Compound)
B... |
DB00377 | DB00862 | 1,494 | 1,005 | [
"DDInter1382",
"DDInter1918"
] | Palonosetron | Vardenafil | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Moderate | 1 | [
[
[
1494,
24,
1005
]
],
[
[
1494,
6,
8374
],
[
8374,
45,
1005
]
],
[
[
1494,
21,
28658
],
[
28658,
60,
1005
]
],
[
[
1494,
23,
112
],
[
11... | [
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vardenafil"
]
],
[
[
"Palonosetron",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Palonosetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vardenafil (Compound)
Palonosetron (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Vardenafil (Compound)
Palonosetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and... |
DB04845 | DB06636 | 309 | 1,623 | [
"DDInter1001",
"DDInter980"
] | Ixabepilone | Isavuconazonium | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
309,
24,
1623
]
],
[
[
309,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
309,
24,
1593
],
[
1593,
63,
1623
]
],
[
[
309,
24,
478
],
[
478,
... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
... | Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Cri... |
DB00907 | DB06704 | 290 | 247 | [
"DDInter427",
"DDInter951"
] | Cocaine (topical) | Iobenguane (I-123) | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | 2-[(3-iodophenyl)methyl]guanidine is an organoiodine compound. | Moderate | 1 | [
[
[
290,
37,
247
]
],
[
[
290,
6,
7390
],
[
7390,
45,
247
]
],
[
[
290,
21,
28681
],
[
28681,
60,
247
]
],
[
[
290,
24,
851
],
[
851,
... | [
[
[
"Cocaine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Iobenguane"
]
],
[
[
"Cocaine",
"{u} (Compound) binds {v} (Gene)",
"SLC6A2"
... | Cocaine may cause a moderate interaction that could exacerbate diseases when taken with Iobenguane and Cocaine may lead to a major life threatening interaction when taken with Iobenguane
Cocaine (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Iobenguane (Compound)
Cocaine (Compound) causes Hypersensitivity... |
DB08820 | DB09330 | 1,478 | 985 | [
"DDInter997",
"DDInter1352"
] | Ivacaftor | Osimertinib | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
1478,
24,
985
]
],
[
[
1478,
63,
1247
],
[
1247,
23,
985
]
],
[
[
1478,
63,
134
],
[
134,
24,
985
]
],
[
[
1478,
24,
1598
],
[
1598,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
],
... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine ... |
DB00196 | DB00496 | 600 | 194 | [
"DDInter743",
"DDInter480"
] | Fluconazole | Darifenacin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Darifenacin (Enablex®, Novartis) is a medication used to treat urinary incontinence. Darifenacin blocks M3 muscarinic acetylcholine receptors, which mediate bladder muscle contractions. This block reduces the urgency to urinate and so it should not be used in people with urinary retention. It is unknown if M3 receptor ... | Moderate | 1 | [
[
[
600,
24,
194
]
],
[
[
600,
25,
704
],
[
704,
1,
194
]
],
[
[
600,
23,
1413
],
[
1413,
1,
194
]
],
[
[
600,
24,
543
],
[
543,
63,... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darifenacin"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl"... | Fluconazole may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Darifenacin (Compound)
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Fexofenadine and Fexofenadine (Compound) resembles Darifenacin (Compound)
Fluconazole m... |
DB00222 | DB01611 | 245 | 1,487 | [
"DDInter825",
"DDInter893"
] | Glimepiride | Hydroxychloroquine | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
245,
24,
1487
]
],
[
[
245,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
245,
24,
1247
],
[
1247,
23,
1487
]
],
[
[
245,
24,
723
],
[
723,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Glimepiride",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect)... | Glimepiride (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when ... |
DB06650 | DB11988 | 1,500 | 270 | [
"DDInter1324",
"DDInter1321"
] | Ofatumumab | Ocrelizumab | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1500,
24,
270
]
],
[
[
1500,
24,
713
],
[
713,
24,
270
]
],
[
[
1500,
63,
259
],
[
259,
24,
270
]
],
[
[
1500,
24,
287
],
[
287,
... | [
[
[
"Ofatumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Ofatumumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
],
... | Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Ofatumumab may cause a moderate interaction that could exacerbate diseases when taken with Rilona... |
DB00387 | DB08897 | 1,386 | 1,429 | [
"DDInter1528",
"DDInter22"
] | Procyclidine | Aclidinium | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Moderate | 1 | [
[
[
1386,
24,
1429
]
],
[
[
1386,
63,
352
],
[
352,
24,
1429
]
],
[
[
1386,
24,
1511
],
[
1511,
24,
1429
]
],
[
[
1386,
6,
4304
],
[
4304,... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aclidinium"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trospium"
],
[
... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Aclidinium
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepen... |
DB00662 | DB00850 | 717 | 1,630 | [
"DDInter1873",
"DDInter1432"
] | Trimethobenzamide | Perphenazine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
717,
24,
1630
]
],
[
[
717,
63,
252
],
[
252,
40,
1630
]
],
[
[
717,
63,
1242
],
[
1242,
24,
1630
]
],
[
[
717,
24,
673
],
[
673,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine and Cetirizine may cause a moderate inte... |
DB00060 | DB00951 | 912 | 1,072 | [
"DDInter947",
"DDInter986"
] | Interferon beta-1a | Isoniazid | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
912,
24,
1072
]
],
[
[
912,
24,
1130
],
[
1130,
63,
1072
]
],
[
[
912,
24,
1031
],
[
1031,
24,
1072
]
],
[
[
912,
63,
305
],
[
305,
... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Pioglitazone and Pioglitazone may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Th... |
DB00749 | DB01254 | 59 | 1,213 | [
"DDInter699",
"DDInter484"
] | Etodolac | Dasatinib | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
59,
25,
1213
]
],
[
[
59,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
59,
24,
738
],
[
738,
63,
1213
]
],
[
[
59,
63,
1555
],
[
1555,
... | [
[
[
"Etodolac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Etodolac",
"{u} (Compound) causes {v} (Side Effect)",
"Body temperature increased"
],
[
"Body temperature increased",
"{u} (Side E... | Etodolac (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Etodolac may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate disea... |
DB01098 | DB06589 | 14 | 1,250 | [
"DDInter1622",
"DDInter1400"
] | Rosuvastatin | Pazopanib | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
14,
24,
1250
]
],
[
[
14,
6,
15333
],
[
15333,
45,
1250
]
],
[
[
14,
18,
1720
],
[
1720,
46,
1250
]
],
[
[
14,
18,
4165
],
[
4165,
... | [
[
[
"Rosuvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Rosuvastatin",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B1"
],
[
"SLCO1B1",
"{u} (Gene) is bound by {v} (Compou... | Rosuvastatin (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Pazopanib (Compound)
Rosuvastatin (Compound) downregulates RELB (Gene) and RELB (Gene) is upregulated by Pazopanib (Compound)
Rosuvastatin (Compound) downregulates EGF (Gene) and EGF (Gene) is downregulated by Pazopanib (Compound)
Rosuvastatin ... |
DB00477 | DB01166 | 216 | 477 | [
"DDInter363",
"DDInter379"
] | Chlorpromazine | Cilostazol | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
216,
24,
477
]
],
[
[
216,
6,
8374
],
[
8374,
45,
477
]
],
[
[
216,
18,
16896
],
[
16896,
57,
477
]
],
[
[
216,
21,
28892
],
[
28892,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Com... | Chlorpromazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cilostazol (Compound)
Chlorpromazine (Compound) downregulates IARS2 (Gene) and IARS2 (Gene) is downregulated by Cilostazol (Compound)
Chlorpromazine (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Ci... |
DB00372 | DB05541 | 999 | 801 | [
"DDInter1793",
"DDInter239"
] | Thiethylperazine | Brivaracetam | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Moderate | 1 | [
[
[
999,
24,
801
]
],
[
[
999,
24,
1411
],
[
1411,
23,
801
]
],
[
[
999,
24,
1374
],
[
1374,
62,
801
]
],
[
[
999,
63,
475
],
[
475,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brivaracetam"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a minor interaction that can limit clinical effects when taken with Brivaracetam
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Abirate... |
DB01267 | DB09104 | 519 | 286 | [
"DDInter1381",
"DDInter1118"
] | Paliperidone | Magnesium hydroxide | Paliperidone is the primary active metabolite of risperidone. The mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. It has been proposed that the drug's therapeutic activity in schizophrenia is mediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
519,
24,
286
]
],
[
[
519,
63,
820
],
[
820,
23,
286
]
],
[
[
519,
63,
688
],
[
688,
24,
286
]
],
[
[
519,
25,
1593
],
[
1593,
2... | [
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Paliperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Paliperidone may cause a moderate interaction that could exacerbate diseases when taken with Salbutam... |
DB00418 | DB00570 | 536 | 147 | [
"DDInter1650",
"DDInter1936"
] | Secobarbital | Vinblastine | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
536,
24,
147
]
],
[
[
536,
63,
134
],
[
134,
24,
147
]
],
[
[
536,
21,
28658
],
[
28658,
60,
147
]
],
[
[
536,
24,
129
],
[
129,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Secobarbital (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Vinblastine (... |
DB00964 | DB01105 | 1,617 | 222 | [
"DDInter110",
"DDInter1665"
] | Apraclonidine | Sibutramine | Apraclonidine, also known as iopidine, is a sympathomimetic used in glaucoma therapy. It is an alpha2-adrenergic agonist. | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1617,
24,
222
]
],
[
[
1617,
21,
28698
],
[
28698,
60,
222
]
],
[
[
1617,
63,
128
],
[
128,
24,
222
]
],
[
[
1617,
24,
1376
],
[
1376,... | [
[
[
"Apraclonidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Apraclonidine",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is... | Apraclonidine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Apraclonidine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine and Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases wh... |
DB09052 | DB09074 | 250 | 1,362 | [
"DDInter220",
"DDInter1327"
] | Blinatumomab | Olaparib | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
250,
24,
1362
]
],
[
[
250,
63,
576
],
[
576,
24,
1362
]
],
[
[
250,
24,
987
],
[
987,
63,
1362
]
],
[
[
250,
64,
990
],
[
990,
... | [
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Blinatumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methadone"
],
[
... | Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Methadone and Methadone may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Blinatumomab may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 1... |
DB00491 | DB09100 | 127 | 320 | [
"DDInter1217",
"DDInter1799"
] | Miglitol | Thyroid, porcine | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
127,
24,
320
]
],
[
[
127,
63,
417
],
[
417,
23,
320
]
],
[
[
127,
63,
73
],
[
73,
24,
320
]
],
[
[
127,
24,
1445
],
[
1445,
24,... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
],
[
... | Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and Phent... |
DB00283 | DB09293 | 701 | 116 | [
"DDInter395",
"DDInter954"
] | Clemastine | Iodide I-131 | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
701,
24,
116
]
],
[
[
701,
35,
252
],
[
252,
24,
116
]
],
[
[
701,
24,
682
],
[
682,
24,
116
]
],
[
[
701,
24,
337
],
[
337,
63,... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken... | Clemastine (Compound) resembles Hydroxyzine (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Clemastine may cause a moderate interaction that ... |
DB00004 | DB00495 | 669 | 139 | [
"DDInter499",
"DDInter1961"
] | Denileukin diftitox | Zidovudine | A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system. | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Moderate | 1 | [
[
[
669,
24,
139
]
],
[
[
669,
24,
1362
],
[
1362,
63,
139
]
],
[
[
669,
24,
599
],
[
599,
24,
139
]
],
[
[
669,
25,
770
],
[
770,
6... | [
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zidovudine"
]
],
[
[
"Denileukin diftitox",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"... | Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine
Denileukin diftitox may cause a moderate interaction that could exacerbate diseases when taken with Alemtuz... |
DB00432 | DB08908 | 1,083 | 713 | [
"DDInter1868",
"DDInter564"
] | Trifluridine | Dimethyl fumarate | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine]. It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activity... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
1083,
24,
713
]
],
[
[
1083,
24,
4
],
[
4,
24,
713
]
],
[
[
1083,
24,
270
],
[
270,
63,
713
]
],
[
[
1083,
40,
141
],
[
141,
24,... | [
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Trifluridine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepe... | Trifluridine may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Trifluridine may cause a moderate interaction that could exacerbate disea... |
DB00377 | DB00813 | 1,494 | 704 | [
"DDInter1382",
"DDInter722"
] | Palonosetron | Fentanyl | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Major | 2 | [
[
[
1494,
25,
704
]
],
[
[
1494,
24,
543
],
[
543,
1,
704
]
],
[
[
1494,
25,
1322
],
[
1322,
40,
704
]
],
[
[
1494,
24,
371
],
[
371,
... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Loperamide"
],
[
"Loperami... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide (Compound) resembles Fentanyl (Compound)
Palonosetron may lead to a major life threatening interaction when taken with Alfentanil and Alfentanil (Compound) resembles Fentanyl (Compound)
Palonosetron ma... |
DB00206 | DB01364 | 1,245 | 22 | [
"DDInter1582",
"DDInter650"
] | Reserpine | Ephedrine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
1245,
24,
22
]
],
[
[
1245,
24,
1445
],
[
1445,
1,
22
]
],
[
[
1245,
6,
6771
],
[
6771,
45,
22
]
],
[
[
1245,
21,
28680
],
[
28680,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pseudoephedrine"
],
[
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Pseudoephedrine and Pseudoephedrine (Compound) resembles Ephedrine (Compound)
Reserpine (Compound) binds SLC18A2 (Gene) and SLC18A2 (Gene) is bound by Ephedrine (Compound)
Reserpine (Compound) causes Rash (Side Effect) and Rash (S... |
DB05528 | DB06317 | 1,070 | 1,626 | [
"DDInter1228",
"DDInter630"
] | Mipomersen | Elotuzumab | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Elotuzumab is a humanized IgG1 (Immunoglobulin G) monoclonal antibody indicated in combination with lenalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received one to three prior therapies. Elotuzumab targets SLAMF7, also known as Signaling Lymphocytic Activation Molecule Family... | Major | 2 | [
[
[
1070,
25,
1626
]
],
[
[
1070,
64,
663
],
[
663,
24,
1626
]
],
[
[
1070,
25,
1468
],
[
1468,
63,
1626
]
],
[
[
1070,
25,
980
],
[
980,
... | [
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Elotuzumab"
]
],
[
[
"Mipomersen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methotrexate"
],
[
"Methotrexate",
"{... | Mipomersen may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Elotuzumab
Mipomersen may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate in... |
DB01611 | DB04948 | 1,487 | 1,084 | [
"DDInter893",
"DDInter1083"
] | Hydroxychloroquine | Lofexidine | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Major | 2 | [
[
[
1487,
25,
1084
]
],
[
[
1487,
63,
112
],
[
112,
23,
1084
]
],
[
[
1487,
63,
618
],
[
618,
24,
1084
]
],
[
[
1487,
24,
774
],
[
774,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lofexidine"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lofexidine
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with A... |
DB00486 | DB01563 | 1,614 | 680 | [
"DDInter1253",
"DDInter349"
] | Nabilone | Chloral hydrate | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | A hypnotic and sedative used in the treatment of insomnia. The safety margin is too narrow for chloral hydrate to be used as a general anesthetic in humans, but it is commonly used for that purpose in animal experiments. It is no longer considered useful as an anti-anxiety medication. | Moderate | 1 | [
[
[
1614,
24,
680
]
],
[
[
1614,
24,
272
],
[
272,
24,
680
]
],
[
[
1614,
40,
530
],
[
530,
24,
680
]
],
[
[
1614,
24,
1609
],
[
1609,
... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloral hydrate"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
],
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Chloral hydrate
Nabilone (Compound) resembles Dronabinol (Compound) and Dronabinol may cause a moderate interacti... |
DB00468 | DB11581 | 1,424 | 1,456 | [
"DDInter1557",
"DDInter1926"
] | Quinine | Venetoclax | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
1424,
25,
1456
]
],
[
[
1424,
23,
1135
],
[
1135,
23,
1456
]
],
[
[
1424,
63,
536
],
[
536,
24,
1456
]
],
[
[
1424,
24,
1476
],
[
1476... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"... | Quinine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Quinine may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may... |
DB00196 | DB01238 | 600 | 673 | [
"DDInter743",
"DDInter118"
] | Fluconazole | Aripiprazole | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
600,
24,
673
]
],
[
[
600,
24,
851
],
[
851,
1,
673
]
],
[
[
600,
24,
827
],
[
827,
40,
673
]
],
[
[
600,
6,
21998
],
[
21998,
4... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compou... |
DB01268 | DB06589 | 1,151 | 1,250 | [
"DDInter1731",
"DDInter1400"
] | Sunitinib | Pazopanib | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Moderate | 1 | [
[
[
1151,
24,
1250
]
],
[
[
1151,
5,
11570
],
[
11570,
44,
1250
]
],
[
[
1151,
6,
16971
],
[
16971,
45,
1250
]
],
[
[
1151,
7,
3553
],
[
3... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pazopanib"
]
],
[
[
"Sunitinib",
"{u} (Compound) treats {v} (Disease)",
"kidney cancer"
],
[
"kidney cancer",
"{u} (Disease) is treated... | Sunitinib (Compound) treats kidney cancer (Disease) and kidney cancer (Disease) is treated by Pazopanib (Compound)
Sunitinib (Compound) binds RIOK2 (Gene) and RIOK2 (Gene) is bound by Pazopanib (Compound)
Sunitinib (Compound) upregulates CRIP1 (Gene) and CRIP1 (Gene) is upregulated by Pazopanib (Compound)
Sunitinib (Co... |
DB00512 | DB00963 | 91 | 1,263 | [
"DDInter1916",
"DDInter241"
] | Vancomycin | Bromfenac | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
91,
24,
1263
]
],
[
[
91,
24,
935
],
[
935,
40,
1263
]
],
[
[
91,
63,
831
],
[
831,
40,
1263
]
],
[
[
91,
24,
1512
],
[
1512,
24... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprofen"
],
[
... | Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles Bromfenac (Compound... |
DB00095 | DB11760 | 66 | 119 | [
"DDInter623",
"DDInter1742"
] | Efalizumab | Talazoparib | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
66,
24,
119
]
],
[
[
66,
24,
1129
],
[
1129,
63,
119
]
],
[
[
66,
63,
599
],
[
599,
24,
119
]
],
[
[
66,
24,
713
],
[
713,
24,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotyp... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen and Human adenovirus e serotype 4 strain cl-68578 antigen may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Efalizumab may cause a mo... |
DB01589 | DB09481 | 481 | 460 | [
"DDInter1552",
"DDInter1113"
] | Quazepam | Magnesium carbonate | Quazepam is a trifluoroethyl benzodiazepine derivative. It was first approved in the US in 1985 and is used as a hypnotic for the treatment of insomnia. It appears to be unique amongst other benzodiazepine derivatives in its relatively high affinity for sleep-promoting α1 subunit-containing GABA<sub>A</sub> receptors a... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
481,
23,
460
]
],
[
[
481,
63,
401
],
[
401,
23,
460
]
],
[
[
481,
40,
1382
],
[
1382,
23,
460
]
],
[
[
481,
1,
905
],
[
905,
23... | [
[
[
"Quazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Quazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Quazepam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Quazepam (Compound) resembles Midazolam (Compound) and Midazolam may cause a minor interaction that can... |
DB01182 | DB01246 | 371 | 820 | [
"DDInter1534",
"DDInter45"
] | Propafenone | Alimemazine | An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
371,
24,
820
]
],
[
[
371,
63,
401
],
[
401,
24,
820
]
],
[
[
371,
1,
939
],
[
939,
24,
820
]
],
[
[
371,
1,
675
],
[
675,
25,
... | [
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Propafenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Propafenone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Propafenone (Compound) resembles Benzphetamine (Compound) and Benzphetamine may cause a moderate interacti... |
DB05812 | DB13074 | 1,374 | 877 | [
"DDInter8",
"DDInter1110"
] | Abiraterone | Macimorelin | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1374,
25,
877
]
],
[
[
1374,
62,
112
],
[
112,
23,
877
]
],
[
[
1374,
24,
1320
],
[
1320,
24,
877
]
],
[
[
1374,
64,
651
],
[
651,
... | [
[
[
"Abiraterone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Abiraterone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Abiraterone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Ela... |
DB05812 | DB15233 | 1,374 | 1,650 | [
"DDInter8",
"DDInter142"
] | Abiraterone | Avapritinib | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
1374,
24,
1650
]
],
[
[
1374,
24,
1478
],
[
1478,
24,
1650
]
],
[
[
1374,
25,
982
],
[
982,
24,
1650
]
],
[
[
1374,
64,
478
],
[
478,
... | [
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Abiraterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Abiraterone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Abiraterone may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause... |
DB00738 | DB01099 | 485 | 1,272 | [
"DDInter1420",
"DDInter744"
] | Pentamidine | Flucytosine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | A fluorinated cytosine analog that is used as an antifungal agent. | Moderate | 1 | [
[
[
485,
24,
1272
]
],
[
[
485,
18,
6104
],
[
6104,
46,
1272
]
],
[
[
485,
7,
6168
],
[
6168,
57,
1272
]
],
[
[
485,
18,
7335
],
[
7335,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flucytosine"
]
],
[
[
"Pentamidine",
"{u} (Compound) downregulates {v} (Gene)",
"COPB2"
],
[
"COPB2",
"{u} (Gene) is upregulated by {... | Pentamidine (Compound) downregulates COPB2 (Gene) and COPB2 (Gene) is upregulated by Flucytosine (Compound)
Pentamidine (Compound) upregulates IGFBP3 (Gene) and IGFBP3 (Gene) is downregulated by Flucytosine (Compound)
Pentamidine (Compound) downregulates LIG1 (Gene) and LIG1 (Gene) is downregulated by Flucytosine (Comp... |
DB00603 | DB11901 | 303 | 913 | [
"DDInter1137",
"DDInter107"
] | Medroxyprogesterone acetate | Apalutamide | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
303,
24,
913
]
],
[
[
303,
40,
312
],
[
312,
23,
913
]
],
[
[
303,
63,
600
],
[
600,
24,
913
]
],
[
[
303,
24,
609
],
[
609,
24,... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} (Compound) resembles {v} (Compound)",
"Eplerenone"
],
[
"Eplereno... | Medroxyprogesterone acetate (Compound) resembles Eplerenone (Compound) and Eplerenone may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may caus... |
DB01225 | DB11071 | 500 | 1,004 | [
"DDInter645",
"DDInter1449"
] | Enoxaparin | Phenyl salicylate | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Phenyl salicylate is a 2-hydroxybenzoic acid phenyl ester. It is utilized in some manufacturing processes of polymers, lacquers, adhesives, waxes, as well as polishes. It is an active ingredient in some pharmaceutical products as a mild analgesic for pain relief by releasing salicylate (found in ). Phenyl salicylate ma... | Moderate | 1 | [
[
[
500,
24,
1004
]
],
[
[
500,
25,
498
],
[
498,
24,
1004
]
],
[
[
500,
24,
1074
],
[
1074,
24,
1004
]
],
[
[
500,
25,
235
],
[
235,
... | [
[
[
"Enoxaparin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyl salicylate"
]
],
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
],
[
"Edoxa... | Enoxaparin may lead to a major life threatening interaction when taken with Edoxaban and Edoxaban may cause a moderate interaction that could exacerbate diseases when taken with Phenyl salicylate
Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123 and Iodide I-123 may... |
DB00877 | DB01215 | 629 | 1,418 | [
"DDInter1678",
"DDInter677"
] | Sirolimus | Estazolam | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Moderate | 1 | [
[
[
629,
24,
1418
]
],
[
[
629,
63,
523
],
[
523,
1,
1418
]
],
[
[
629,
63,
1216
],
[
1216,
40,
1418
]
],
[
[
629,
24,
481
],
[
481,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprazolam"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Alprazolam and Alprazolam (Compound) resembles Estazolam (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Estazolam (Compound)
Siro... |
DB00295 | DB00502 | 475 | 1,300 | [
"DDInter1244",
"DDInter853"
] | Morphine | Haloperidol | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the brain, it exerts its antipsychotic effect through its strong antagonism of the do... | Major | 2 | [
[
[
475,
25,
1300
]
],
[
[
475,
25,
78
],
[
78,
1,
1300
]
],
[
[
475,
24,
543
],
[
543,
63,
1300
]
],
[
[
475,
24,
1242
],
[
1242,
2... | [
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Haloperidol"
]
],
[
[
"Morphine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Droperidol"
],
[
"Droperidol",
"{u} (Com... | Morphine may lead to a major life threatening interaction when taken with Droperidol and Droperidol (Compound) resembles Haloperidol (Compound)
Morphine may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cause a moderate interaction that could exacerbate diseas... |
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