drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00959 | DB10795 | 1,486 | 221 | [
"DDInter1191",
"DDInter1486"
] | Methylprednisolone | Poliovirus type 1 antigen (formaldehyde inactivated) | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
1486,
24,
221
]
],
[
[
1486,
64,
581
],
[
581,
24,
221
]
],
[
[
1486,
63,
599
],
[
599,
24,
221
]
],
[
[
1486,
25,
384
],
[
384,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Methylprednisolone",
"{u} may lead to a major life threatening interaction when taken wi... | Methylprednisolone may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Methylprednisolone may cause a moderate interaction that could exacerbate dis... |
DB00509 | DB00877 | 1,294 | 629 | [
"DDInter530",
"DDInter1678"
] | Dextrothyroxine | Sirolimus | The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinate... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
1294,
24,
629
]
],
[
[
1294,
6,
15333
],
[
15333,
45,
629
]
],
[
[
1294,
7,
19948
],
[
19948,
46,
629
]
],
[
[
1294,
18,
2183
],
[
218... | [
[
[
"Dextrothyroxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Dextrothyroxine",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B1"
],
[
"SLCO1B1",
"{u} (Gene) is bound by {v} (... | Dextrothyroxine (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Sirolimus (Compound)
Dextrothyroxine (Compound) upregulates CNPY3 (Gene) and CNPY3 (Gene) is upregulated by Sirolimus (Compound)
Dextrothyroxine (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Sirolimus (Compound)
... |
DB01105 | DB01174 | 222 | 697 | [
"DDInter1665",
"DDInter1442"
] | Sibutramine | Phenobarbital | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Moderate | 1 | [
[
[
222,
24,
697
]
],
[
[
222,
63,
759
],
[
759,
1,
697
]
],
[
[
222,
63,
536
],
[
536,
40,
697
]
],
[
[
222,
6,
8374
],
[
8374,
45,... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
],
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Primidone and Primidone (Compound) resembles Phenobarbital (Compound)
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital (Compound) resembles Phenobarbital (... |
DB00069 | DB00515 | 367 | 589 | [
"DDInter946",
"DDInter387"
] | Interferon alfacon-1 | Cisplatin | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
367,
24,
589
]
],
[
[
367,
24,
1468
],
[
1468,
63,
589
]
],
[
[
367,
25,
1477
],
[
1477,
63,
589
]
],
[
[
367,
24,
168
],
[
168,
... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatini... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin
Interferon alfacon-1 may lead to a major life threatening interaction when taken with Telbivudine and Tel... |
DB06605 | DB08912 | 1,409 | 1,040 | [
"DDInter108",
"DDInter462"
] | Apixaban | Dabrafenib | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
1409,
24,
1040
]
],
[
[
1409,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
1409,
21,
28855
],
[
28855,
60,
1040
]
],
[
[
1409,
63,
1101
],
[
1... | [
[
[
"Apixaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Apixaban",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Apixaban (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Apixaban (Compound) causes Haemorrhage intracranial (Side Effect) and Haemorrhage intracranial (Side Effect) is caused by Dabrafenib (Compound)
Apixaban may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00366 | DB11160 | 1,594 | 337 | [
"DDInter600",
"DDInter1459"
] | Doxylamine | Phenyltoloxamine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
1594,
24,
337
]
],
[
[
1594,
24,
820
],
[
820,
24,
337
]
],
[
[
1594,
35,
128
],
[
128,
24,
337
]
],
[
[
1594,
74,
701
],
[
701,
... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Doxylamine (Compound) resembles Dexbrompheniramine (Compound) and Doxylamine may cause a moderate intera... |
DB00911 | DB01394 | 458 | 1,554 | [
"DDInter1811",
"DDInter431"
] | Tinidazole | Colchicine | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Colchicine is an alkaloid drug derived from a plant belonging to the Lily family, known as _Colchicum autumnale_, or "autumn crocus." Its use was first approved by the FDA in 1961. Colchicine is used in the treatment of gout flares and Familial Mediterranean fever, and prevention of major cardiovascular events. It has ... | Moderate | 1 | [
[
[
458,
24,
1554
]
],
[
[
458,
6,
8374
],
[
8374,
45,
1554
]
],
[
[
458,
21,
28714
],
[
28714,
60,
1554
]
],
[
[
458,
24,
1017
],
[
1017,... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Colchicine"
]
],
[
[
"Tinidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Tinidazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Colchicine (Compound)
Tinidazole (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Colchicine (Compound)
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlat... |
DB00047 | DB02701 | 176 | 1,632 | [
"DDInter932",
"DDInter1289"
] | Insulin glargine | Nicotinamide | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. | Moderate | 1 | [
[
[
176,
24,
1632
]
],
[
[
176,
24,
135
],
[
135,
63,
1632
]
],
[
[
176,
24,
245
],
[
245,
24,
1632
]
],
[
[
176,
63,
305
],
[
305,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nicotinamide"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Albiglutide"
... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Albiglutide and Albiglutide may cause a moderate interaction that could exacerbate diseases when taken with Nicotinamide
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Glime... |
DB01611 | DB04946 | 1,487 | 924 | [
"DDInter893",
"DDInter907"
] | Hydroxychloroquine | Iloperidone | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Major | 2 | [
[
[
1487,
25,
924
]
],
[
[
1487,
64,
1664
],
[
1664,
1,
924
]
],
[
[
1487,
64,
1425
],
[
1425,
25,
924
]
],
[
[
1487,
64,
519
],
[
519,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iloperidone"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risperidone"
],
[
"Risperi... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Hydroxychloroquine may lead to a major life threatening interaction when taken with Cisapride and Cisapride may lead to a major life threatening interaction when ta... |
DB01110 | DB06212 | 86 | 165 | [
"DDInter1209",
"DDInter1833"
] | Miconazole | Tolvaptan | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Tolvaptan is used to treat low blood sodium levels (hyponatremia) associated with various conditions like congestive heart failure, cirrhosis, and syndrome of inappropriate antidiuretic hormones (SIADH). FDA approved on May 19, 2009. | Moderate | 1 | [
[
[
86,
24,
165
]
],
[
[
86,
63,
1080
],
[
1080,
1,
165
]
],
[
[
86,
6,
8374
],
[
8374,
45,
165
]
],
[
[
86,
21,
28681
],
[
28681,
6... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolvaptan"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Tolvaptan (Compound)
Miconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Tolvaptan (Compound)
Miconazole (Compound) causes Hypersensitivity (Side Effect) and Hype... |
DB01006 | DB04868 | 300 | 478 | [
"DDInter1040",
"DDInter1293"
] | Letrozole | Nilotinib | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
300,
24,
478
]
],
[
[
300,
6,
8374
],
[
8374,
45,
478
]
],
[
[
300,
21,
28963
],
[
28963,
60,
478
]
],
[
[
300,
62,
307
],
[
307,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Letrozole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Letrozole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Letrozole (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Letrozole may cause a minor interaction that can limit clinical effects when taken with Modafinil and Modafinil may ca... |
DB01097 | DB12500 | 1,377 | 283 | [
"DDInter1033",
"DDInter714"
] | Leflunomide | Fedratinib | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1377,
25,
283
]
],
[
[
1377,
25,
351
],
[
351,
23,
283
]
],
[
[
1377,
25,
69
],
[
69,
63,
283
]
],
[
[
1377,
25,
1398
],
[
1398,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",
"{u}... | Leflunomide may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Leflunomide may lead to a major life threatening interaction when taken with Pralsetinib and Pralsetinib may cause a moderate in... |
DB00357 | DB08816 | 1,051 | 578 | [
"DDInter71",
"DDInter1802"
] | Aminoglutethimide | Ticagrelor | An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant prope... | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Moderate | 1 | [
[
[
1051,
24,
578
]
],
[
[
1051,
6,
8374
],
[
8374,
45,
578
]
],
[
[
1051,
21,
28762
],
[
28762,
60,
578
]
],
[
[
1051,
24,
907
],
[
907,
... | [
[
[
"Aminoglutethimide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
]
],
[
[
"Aminoglutethimide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v... | Aminoglutethimide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ticagrelor (Compound)
Aminoglutethimide (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ticagrelor (Compound)
Aminoglutethimide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00717 | DB11828 | 1,197 | 1,406 | [
"DDInter1312",
"DDInter1281"
] | Norethisterone | Neratinib | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
1197,
24,
1406
]
],
[
[
1197,
24,
392
],
[
392,
24,
1406
]
],
[
[
1197,
1,
566
],
[
566,
24,
1406
]
],
[
[
1197,
24,
1619
],
[
1619,
... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
],
... | Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Norethisterone (Compound) resembles Levonorgestrel (Compound) and Levonorgestrel may cause a moderate interacti... |
DB00352 | DB01268 | 482 | 1,151 | [
"DDInter1814",
"DDInter1731"
] | Tioguanine | Sunitinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Moderate | 1 | [
[
[
482,
24,
1151
]
],
[
[
482,
6,
9320
],
[
9320,
45,
1151
]
],
[
[
482,
21,
28868
],
[
28868,
60,
1151
]
],
[
[
482,
24,
1247
],
[
1247,... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
]
],
[
[
"Tioguanine",
"{u} (Compound) binds {v} (Gene)",
"ABCC4"
],
[
"ABCC4",
"{u} (Gene) is bound by {v} (Compound)",
... | Tioguanine (Compound) binds ABCC4 (Gene) and ABCC4 (Gene) is bound by Sunitinib (Compound)
Tioguanine (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Sunitinib (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and ... |
DB00701 | DB09039 | 1,091 | 1,670 | [
"DDInter90",
"DDInter629"
] | Amprenavir | Eliglustat | Amprenavir is a protease inhibitor used to treat HIV infection. | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Major | 2 | [
[
[
1091,
25,
1670
]
],
[
[
1091,
25,
1135
],
[
1135,
62,
1670
]
],
[
[
1091,
24,
1409
],
[
1409,
24,
1670
]
],
[
[
1091,
24,
1499
],
[
14... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eliglustat"
]
],
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may... | Amprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Eliglustat
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may cause a modera... |
DB00431 | DB00647 | 1,503 | 675 | [
"DDInter1072",
"DDInter528"
] | Lindane | Dextropropoxyphene | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Moderate | 1 | [
[
[
1503,
24,
675
]
],
[
[
1503,
24,
1301
],
[
1301,
40,
675
]
],
[
[
1503,
24,
1164
],
[
1164,
1,
675
]
],
[
[
1503,
24,
820
],
[
820,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dextropropoxyphene"
]
],
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levacetylmethadol"
],... | Lindane may cause a moderate interaction that could exacerbate diseases when taken with Levacetylmethadol and Levacetylmethadol (Compound) resembles Dextropropoxyphene (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles De... |
DB00393 | DB00653 | 854 | 544 | [
"DDInter1295",
"DDInter1120"
] | Nimodipine | Magnesium sulfate | Nimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nimodipine prevents calcium-dependent smooth muscle contraction ... | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Moderate | 1 | [
[
[
854,
24,
544
]
],
[
[
854,
6,
2044
],
[
2044,
45,
544
]
],
[
[
854,
21,
28717
],
[
28717,
60,
544
]
],
[
[
854,
1,
84
],
[
84,
2... | [
[
[
"Nimodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium sulfate"
]
],
[
[
"Nimodipine",
"{u} (Compound) binds {v} (Gene)",
"CACNB2"
],
[
"CACNB2",
"{u} (Gene) is bound by {v} (Comp... | Nimodipine (Compound) binds CACNB2 (Gene) and CACNB2 (Gene) is bound by Magnesium sulfate (Compound)
Nimodipine (Compound) causes Flushing (Side Effect) and Flushing (Side Effect) is caused by Magnesium sulfate (Compound)
Nimodipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate intera... |
DB00327 | DB01246 | 421 | 820 | [
"DDInter890",
"DDInter45"
] | Hydromorphone | Alimemazine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
421,
24,
820
]
],
[
[
421,
24,
104
],
[
104,
40,
820
]
],
[
[
421,
24,
401
],
[
401,
24,
820
]
],
[
[
421,
24,
649
],
[
649,
1,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interac... |
DB00877 | DB08860 | 629 | 788 | [
"DDInter1678",
"DDInter1479"
] | Sirolimus | Pitavastatin | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
629,
24,
788
]
],
[
[
629,
24,
671
],
[
671,
1,
788
]
],
[
[
629,
24,
700
],
[
700,
40,
788
]
],
[
[
629,
6,
4973
],
[
4973,
45,... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
[
... | Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin (Co... |
DB06077 | DB08882 | 879 | 1,281 | [
"DDInter1102",
"DDInter1070"
] | Lumateperone | Linagliptin | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
879,
24,
1281
]
],
[
[
879,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
879,
25,
1320
],
[
1320,
63,
1281
]
],
[
[
879,
25,
868
],
[
868,
... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Lumateperone may lead to a major life threatening interaction when taken with Elagolix and Elagolix may cause a moderate interaction that could exacerbate di... |
DB00712 | DB09122 | 1,274 | 1,613 | [
"DDInter763",
"DDInter1409"
] | Flurbiprofen | Peginterferon beta-1a | Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically p... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1274,
24,
1613
]
],
[
[
1274,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
1274,
63,
152
],
[
152,
24,
1613
]
],
[
[
1274,
24,
1383
],
[
1383... | [
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"... | Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Bose... |
DB00055 | DB00176 | 834 | 529 | [
"DDInter605",
"DDInter770"
] | Drotrecogin alfa | Fluvoxamine | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Moderate | 1 | [
[
[
834,
24,
529
]
],
[
[
834,
64,
20
],
[
20,
24,
529
]
],
[
[
834,
25,
1274
],
[
1274,
63,
529
]
],
[
[
834,
25,
1172
],
[
1172,
2... | [
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvoxamine"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tenecteplase"
],
[
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Fluvoxamine
Drotrecogin alfa may lead to a major life threatening interaction when taken with Flurbiprofen and Flurbiprofen may ... |
DB00863 | DB04834 | 1,194 | 276 | [
"DDInter1568",
"DDInter1571"
] | Ranitidine | Rapacuronium | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Rapacuronium was withdrawn in 2001 in many countries due to risk of fatal bronchospasm. | Minor | 0 | [
[
[
1194,
23,
276
]
],
[
[
1194,
63,
1031
],
[
1031,
24,
276
]
],
[
[
1194,
6,
8374
],
[
8374,
45,
613
],
[
613,
23,
276
]
],
[
[
1194,
... | [
[
[
"Ranitidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Rapacuronium"
]
],
[
[
"Ranitidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theophylline"
],
[
... | Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Rapacuronium
Ranitidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound) and Irinotec... |
DB00342 | DB04948 | 1,181 | 1,084 | [
"DDInter1770",
"DDInter1083"
] | Terfenadine | Lofexidine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Moderate | 1 | [
[
[
1181,
24,
1084
]
],
[
[
1181,
23,
112
],
[
112,
23,
1084
]
],
[
[
1181,
24,
774
],
[
774,
63,
1084
]
],
[
[
1181,
24,
688
],
[
688,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lofexidine"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lofexidine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Deg... |
DB00662 | DB01209 | 717 | 1,359 | [
"DDInter1873",
"DDInter531"
] | Trimethobenzamide | Dezocine | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
717,
24,
1359
]
],
[
[
717,
63,
234
],
[
234,
1,
1359
]
],
[
[
717,
63,
1594
],
[
1594,
24,
1359
]
],
[
[
717,
24,
516
],
[
516,
... | [
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Trimethobenzamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
... | Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Trimethobenzamide may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interact... |
DB01024 | DB11988 | 1,096 | 270 | [
"DDInter1252",
"DDInter1321"
] | Mycophenolic acid | Ocrelizumab | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
1096,
24,
270
]
],
[
[
1096,
23,
1193
],
[
1193,
23,
270
]
],
[
[
1096,
62,
1461
],
[
1461,
23,
270
]
],
[
[
1096,
24,
713
],
[
713,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate... | Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Vita... |
DB00459 | DB01097 | 640 | 1,377 | [
"DDInter21",
"DDInter1033"
] | Acitretin | Leflunomide | An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Major | 2 | [
[
[
640,
25,
1377
]
],
[
[
640,
21,
30543
],
[
30543,
60,
1377
]
],
[
[
640,
24,
242
],
[
242,
63,
1377
]
],
[
[
640,
24,
959
],
[
959,
... | [
[
[
"Acitretin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Leflunomide"
]
],
[
[
"Acitretin",
"{u} (Compound) causes {v} (Side Effect)",
"Skin nodule"
],
[
"Skin nodule",
"{u} (Side Effect) is caused by {v} (C... | Acitretin (Compound) causes Skin nodule (Side Effect) and Skin nodule (Side Effect) is caused by Leflunomide (Compound)
Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Remdesivir and Remdesivir may cause a moderate interaction that could exacerbate diseases when taken with Lefl... |
DB00241 | DB01069 | 288 | 401 | [
"DDInter257",
"DDInter1533"
] | Butalbital | Promethazine | Butalbital, or 5-allyl-5-isobutylbarbituric acid, is a derivative of barbituric acid which the hydrogens at position 5 are substituted by an allyl group and an isobutyl group. It is a short-to-intermediate acting member of barbiturates that exhibit muscle-relaxing and anti-anxiety properties that produce central nervou... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
288,
24,
401
]
],
[
[
288,
24,
1264
],
[
1264,
63,
401
]
],
[
[
288,
24,
104
],
[
104,
24,
401
]
],
[
[
288,
24,
112
],
[
112,
2... | [
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Butalbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Butalbital may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdila... |
DB00011 | DB00330 | 1,451 | 238 | [
"DDInter944",
"DDInter689"
] | Interferon alfa-n1 | Ethambutol | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Ethambutol is a bacteriostatic agent indicated alongside medications such as [isoniazid], [rifampin], and [pyrazinamide] in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out of a need for therapies active against isoniazid resistant strains of _Mycob... | Moderate | 1 | [
[
[
1451,
24,
238
]
],
[
[
1451,
63,
1057
],
[
1057,
24,
238
]
],
[
[
1451,
24,
458
],
[
458,
63,
238
]
],
[
[
1451,
24,
10
],
[
10,
... | [
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethambutol"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etanercept"... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Tinid... |
DB00366 | DB00804 | 1,594 | 1,507 | [
"DDInter600",
"DDInter543"
] | Doxylamine | Dicyclomine | Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism. | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Moderate | 1 | [
[
[
1594,
24,
1507
]
],
[
[
1594,
6,
7992
],
[
7992,
45,
1507
]
],
[
[
1594,
21,
29231
],
[
29231,
60,
1507
]
],
[
[
1594,
25,
551
],
[
55... | [
[
[
"Doxylamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicyclomine"
]
],
[
[
"Doxylamine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)",
... | Doxylamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Dicyclomine (Compound)
Doxylamine (Compound) causes Cardiac disorder (Side Effect) and Cardiac disorder (Side Effect) is caused by Dicyclomine (Compound)
Doxylamine may lead to a major life threatening interaction when taken with Phenelzine and Phene... |
DB09570 | DB10989 | 1,480 | 496 | [
"DDInter1002",
"DDInter858"
] | Ixazomib | Hepatitis A Vaccine | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Moderate | 1 | [
[
[
1480,
24,
496
]
],
[
[
1480,
63,
4
],
[
4,
24,
496
]
],
[
[
1480,
24,
738
],
[
738,
63,
496
]
],
[
[
1480,
64,
976
],
[
976,
24,... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
]
],
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Omacetaxine mepesuccin... | Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine
Ixazomib may cause a moderate interaction that could exacerbate diseases wh... |
DB00208 | DB09118 | 1,018 | 1,580 | [
"DDInter1804",
"DDInter1711"
] | Ticlopidine | Stiripentol | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
1018,
24,
1580
]
],
[
[
1018,
25,
1409
],
[
1409,
24,
1580
]
],
[
[
1018,
24,
283
],
[
283,
63,
1580
]
],
[
[
1018,
23,
251
],
[
251,
... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Ticlopidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
],
[
"Apixaban"... | Ticlopidine may lead to a major life threatening interaction when taken with Apixaban and Apixaban may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a... |
DB00970 | DB09054 | 0 | 384 | [
"DDInter466",
"DDInter905"
] | Dactinomycin | Idelalisib | A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also d... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
0,
24,
384
]
],
[
[
0,
24,
328
],
[
328,
24,
384
]
],
[
[
0,
63,
58
],
[
58,
24,
384
]
],
[
[
0,
24,
287
],
[
287,
63,
384... | [
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Dactinomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
],
... | Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Dactinomycin may cause a moderate interaction that could exacerbate diseases when taken with Alefacept... |
DB00436 | DB11057 | 323 | 720 | [
"DDInter179",
"DDInter1223"
] | Bendroflumethiazide | Mineral oil | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
323,
24,
720
]
],
[
[
323,
24,
175
],
[
175,
24,
720
]
],
[
[
323,
63,
160
],
[
160,
24,
720
]
],
[
[
323,
40,
674
],
[
674,
24,... | [
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Bendroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcin... | Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Bendroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00899 | DB01181 | 411 | 1,532 | [
"DDInter1579",
"DDInter906"
] | Remifentanil | Ifosfamide | Remifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depress... | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
411,
24,
1532
]
],
[
[
411,
21,
28743
],
[
28743,
60,
1532
]
],
[
[
411,
63,
1648
],
[
1648,
24,
1532
]
],
[
[
411,
24,
401
],
[
401,
... | [
[
[
"Remifentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Remifentanil",
"{u} (Compound) causes {v} (Side Effect)",
"Atrial fibrillation"
],
[
"Atrial fibrillation",
"{... | Remifentanil (Compound) causes Atrial fibrillation (Side Effect) and Atrial fibrillation (Side Effect) is caused by Ifosfamide (Compound)
Remifentanil may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseas... |
DB00731 | DB01211 | 1,144 | 609 | [
"DDInter1269",
"DDInter393"
] | Nateglinide | Clarithromycin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
1144,
24,
609
]
],
[
[
1144,
6,
7524
],
[
7524,
45,
609
]
],
[
[
1144,
21,
28662
],
[
28662,
60,
609
]
],
[
[
1144,
63,
600
],
[
600,
... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Nateglinide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compo... | Nateglinide (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Nateglinide (Compound) causes Tremor (Side Effect) and Tremor (Side Effect) is caused by Clarithromycin (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB00398 | DB01030 | 79 | 869 | [
"DDInter1702",
"DDInter1835"
] | Sorafenib | Topotecan | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
79,
24,
869
]
],
[
[
79,
24,
613
],
[
613,
24,
869
]
],
[
[
79,
6,
17404
],
[
17404,
45,
869
]
],
[
[
79,
7,
5677
],
[
5677,
46,... | [
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Sorafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
],
[
... | Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Irinotecan and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Sorafenib (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Topotecan (Compound)
Sorafenib (Compound) upr... |
DB06595 | DB15091 | 1,491 | 676 | [
"DDInter1214",
"DDInter1901"
] | Midostaurin | Upadacitinib | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1491,
25,
676
]
],
[
[
1491,
24,
1430
],
[
1430,
24,
676
]
],
[
[
1491,
63,
1249
],
[
1249,
24,
676
]
],
[
[
1491,
25,
1593
],
[
1593,... | [
[
[
"Midostaurin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipu... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and... |
DB00017 | DB00529 | 1,505 | 789 | [
"DDInter1636",
"DDInter779"
] | Salmon calcitonin | Foscarnet | Synthetic peptide, 32 residues long formulated as a nasal spray. | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Moderate | 1 | [
[
[
1505,
24,
789
]
],
[
[
1505,
25,
922
],
[
922,
64,
789
]
],
[
[
1505,
23,
752
],
[
752,
6,
10612
],
[
10612,
45,
789
]
],
[
[
1505,
... | [
[
[
"Salmon calcitonin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Foscarnet"
]
],
[
[
"Salmon calcitonin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etelcalcetide"
],
[
... | Salmon calcitonin may lead to a major life threatening interaction when taken with Etelcalcetide and Etelcalcetide may lead to a major life threatening interaction when taken with Foscarnet
Salmon calcitonin may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Cimetidine (Compoun... |
DB00461 | DB11703 | 598 | 405 | [
"DDInter1254",
"DDInter9"
] | Nabumetone | Acalabrutinib | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Major | 2 | [
[
[
598,
25,
405
]
],
[
[
598,
23,
1194
],
[
1194,
24,
405
]
],
[
[
598,
24,
1619
],
[
1619,
63,
405
]
],
[
[
598,
24,
121
],
[
121,
... | [
[
[
"Nabumetone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acalabrutinib"
]
],
[
[
"Nabumetone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ranitidine"
],
[
"Ranitidin... | Nabumetone may cause a minor interaction that can limit clinical effects when taken with Ranitidine and Ranitidine may cause a moderate interaction that could exacerbate diseases when taken with Acalabrutinib
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucapa... |
DB00601 | DB01041 | 453 | 770 | [
"DDInter1073",
"DDInter1789"
] | Linezolid | Thalidomide | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
453,
24,
770
]
],
[
[
453,
7,
7669
],
[
7669,
46,
770
]
],
[
[
453,
18,
20113
],
[
20113,
57,
770
]
],
[
[
453,
21,
28784
],
[
28784,
... | [
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Linezolid",
"{u} (Compound) upregulates {v} (Gene)",
"DDIT4"
],
[
"DDIT4",
"{u} (Gene) is upregulated by {v} (Co... | Linezolid (Compound) upregulates DDIT4 (Gene) and DDIT4 (Gene) is upregulated by Thalidomide (Compound)
Linezolid (Compound) downregulates IER3 (Gene) and IER3 (Gene) is downregulated by Thalidomide (Compound)
Linezolid (Compound) causes Thrombocytopenia (Side Effect) and Thrombocytopenia (Side Effect) is caused by Tha... |
DB00401 | DB11718 | 84 | 927 | [
"DDInter1298",
"DDInter640"
] | Nisoldipine | Encorafenib | Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contractio... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
84,
24,
927
]
],
[
[
84,
1,
1081
],
[
1081,
24,
927
]
],
[
[
84,
63,
1010
],
[
1010,
24,
927
]
],
[
[
84,
24,
770
],
[
770,
24,
... | [
[
[
"Nisoldipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Nisoldipine",
"{u} (Compound) resembles {v} (Compound)",
"Nicardipine"
],
[
"Nicardipine",
"{u} may cause a mo... | Nisoldipine (Compound) resembles Nicardipine (Compound) and Nicardipine may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Mefloquine may cause a moderate interaction that ... |
DB00374 | DB08918 | 1,061 | 41 | [
"DDInter1852",
"DDInter1059"
] | Treprostinil | Levomilnacipran | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Levomilnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI), although it is a more potent inhibitor of norepinephrine reuptake than serotonin reuptake.[A261181, A38560] Levomilnacipran is the more active 1S,2R-enantiomer in the racemate [milnacipran].[A261181, L47956] Once administered, interc... | Moderate | 1 | [
[
[
1061,
24,
41
]
],
[
[
1061,
24,
901
],
[
901,
40,
41
]
],
[
[
1061,
21,
28643
],
[
28643,
60,
41
]
],
[
[
1061,
25,
498
],
[
498,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levomilnacipran"
]
],
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Milnacipran"
]... | Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Milnacipran and Milnacipran (Compound) resembles Levomilnacipran (Compound)
Treprostinil (Compound) causes Infection (Side Effect) and Infection (Side Effect) is caused by Levomilnacipran (Compound)
Treprostinil may lead to a m... |
DB00912 | DB01064 | 473 | 1,148 | [
"DDInter1581",
"DDInter987"
] | Repaglinide | Isoprenaline | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
473,
24,
1148
]
],
[
[
473,
63,
1636
],
[
1636,
24,
1148
]
],
[
[
473,
24,
480
],
[
480,
24,
1148
]
],
[
[
473,
21,
29282
],
[
29282,
... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylephrine"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Phenylephrine and Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Formoterol ... |
DB08904 | DB10343 | 375 | 962 | [
"DDInter342",
"DDInter160"
] | Certolizumab pegol | Bacillus calmette-guerin substrain tice live antigen | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
375,
25,
962
]
],
[
[
375,
64,
617
],
[
617,
24,
962
]
],
[
[
375,
64,
1057
],
[
1057,
25,
962
]
],
[
[
375,
25,
270
],
[
270,
6... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Certolizumab pegol may lead to a major life threatening interaction when taken with Budesonide and Budesonide may cause a moderate interaction that could exacerbate diseases when taken with Bacillus calmette-guerin substrain tice live antigen
Certolizumab pegol may lead to a major life threatening interaction when take... |
DB00612 | DB09135 | 1,121 | 1,211 | [
"DDInter216",
"DDInter967"
] | Bisoprolol | Ioxilan | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Ioxilan is a tri-iodinated diagnostic contrast agent. Intravascular injection results in opacification of vessels in the path of flow of the contrast medium, permitting radiographic visualization of the internal structures of the human body until significant hemodilution occurs. | Moderate | 1 | [
[
[
1121,
24,
1211
]
],
[
[
1121,
1,
887
],
[
887,
24,
1211
]
],
[
[
1121,
24,
1013
],
[
1013,
63,
1211
]
],
[
[
1121,
24,
512
],
[
512,
... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioxilan"
]
],
[
[
"Bisoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Pindolol"
],
[
"Pindolol",
"{u} may cause a moderate inter... | Bisoprolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Ioxilan
Bisoprolol may cause a moderate interaction that could exacerbate diseases when taken with Tyropanoic acid and Tyropanoic acid may cause a moderate interaction that co... |
DB00945 | DB00963 | 1,479 | 1,263 | [
"DDInter20",
"DDInter241"
] | Acetylsalicylic acid | Bromfenac | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Moderate | 1 | [
[
[
1479,
24,
1263
]
],
[
[
1479,
24,
935
],
[
935,
40,
1263
]
],
[
[
1479,
63,
831
],
[
831,
40,
1263
]
],
[
[
1479,
63,
1512
],
[
1512,
... | [
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bromfenac"
]
],
[
[
"Acetylsalicylic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketoprof... | Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Ketoprofen and Ketoprofen (Compound) resembles Bromfenac (Compound)
Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Indomethacin and Indomethacin (Compound) resembles... |
DB08880 | DB11828 | 1,510 | 1,406 | [
"DDInter1771",
"DDInter1281"
] | Teriflunomide | Neratinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
1510,
24,
1406
]
],
[
[
1510,
64,
392
],
[
392,
24,
1406
]
],
[
[
1510,
63,
1197
],
[
1197,
24,
1406
]
],
[
[
1510,
25,
710
],
[
710,
... | [
[
[
"Teriflunomide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lapatinib"
],
[
"Lapati... | Teriflunomide may lead to a major life threatening interaction when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Teriflunomide may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone... |
DB04843 | DB11160 | 1,511 | 337 | [
"DDInter1149",
"DDInter1459"
] | Mepenzolate | Phenyltoloxamine | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Phenyltoloxamine is an antihistamine drug with sedative and analgesic effects. It is a H1 receptor blocker and a member of the ethanolamine class of antihistaminergic drugs. It is available in combination products that also contain other analgesics and antitussives such as acetaminophen. Phenyltoloxamine citrate is the... | Moderate | 1 | [
[
[
1511,
24,
337
]
],
[
[
1511,
63,
820
],
[
820,
24,
337
]
],
[
[
1511,
24,
849
],
[
849,
24,
337
]
],
[
[
1511,
74,
701
],
[
701,
... | [
[
[
"Mepenzolate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenyltoloxamine"
]
],
[
[
"Mepenzolate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],... | Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a moderate interaction that could exacerbate diseases when taken with Phenyltoloxamine
Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine ... |
DB00373 | DB00572 | 461 | 85 | [
"DDInter1809",
"DDInter136"
] | Timolol | Atropine | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
461,
24,
85
]
],
[
[
461,
24,
19
],
[
19,
24,
85
]
],
[
[
461,
25,
1166
],
[
1166,
40,
85
]
],
[
[
461,
21,
28719
],
[
28719,
60... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
"Hy... | Timolol may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Timolol may lead to a major life threatening interaction when taken with Dolasetron and Dolasetron (Compound) resem... |
DB00731 | DB06718 | 1,144 | 1,687 | [
"DDInter1269",
"DDInter1709"
] | Nateglinide | Stanozolol | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Moderate | 1 | [
[
[
1144,
24,
1687
]
],
[
[
1144,
63,
1197
],
[
1197,
1,
1687
]
],
[
[
1144,
24,
1546
],
[
1546,
1,
1687
]
],
[
[
1144,
63,
1561
],
[
1561... | [
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stanozolol"
]
],
[
[
"Nateglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
],
... | Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Norethisterone and Norethisterone (Compound) resembles Stanozolol (Compound)
Nateglinide may cause a moderate interaction that could exacerbate diseases when taken with Methyltestosterone and Methyltestosterone (Compound) resemb... |
DB00353 | DB00759 | 588 | 1,620 | [
"DDInter1187",
"DDInter1783"
] | Methylergometrine | Tetracycline | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Tetracycline is a broad spectrum polyketide antibiotic produced by the Streptomyces genus of Actinobacteria. It exerts a bacteriostatic effect on bacteria by binding reversible to the bacterial 30S ribosomal subunit and blocking incoming aminoacyl tRNA from binding to the ribosome acceptor site. It also binds to some e... | Moderate | 1 | [
[
[
588,
24,
1620
]
],
[
[
588,
24,
1572
],
[
1572,
40,
1620
]
],
[
[
588,
63,
964
],
[
964,
40,
1620
]
],
[
[
588,
6,
8374
],
[
8374,
... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracycline"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycl... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Tetracycline (Compound)
Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resemb... |
DB01240 | DB09038 | 885 | 1,450 | [
"DDInter657",
"DDInter636"
] | Epoprostenol | Empagliflozin | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Empagliflozin is an inhibitor of sodium-glucose co-transporter-2 (SGLT2), the transporters primarily responsible for the reabsorption of glucose in the kidney. It is used clinically as an adjunct to diet and exercise, often in combination with other drug therapies,[L13673,L13679,L11479] for the management of type 2 dia... | Moderate | 1 | [
[
[
885,
24,
1450
]
],
[
[
885,
63,
461
],
[
461,
24,
1450
]
],
[
[
885,
40,
1061
],
[
1061,
24,
1450
]
],
[
[
885,
24,
911
],
[
911,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
]
],
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
... | Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin
Epoprostenol (Compound) resembles Treprostinil (Compound) and Treprostinil may cause a moderate interaction that ... |
DB00612 | DB11126 | 1,121 | 900 | [
"DDInter216",
"DDInter276"
] | Bisoprolol | Calcium gluconate | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle. Calcium Gluconate Injecti... | Moderate | 1 | [
[
[
1121,
24,
900
]
],
[
[
1121,
1,
887
],
[
887,
24,
900
]
],
[
[
1121,
62,
542
],
[
542,
24,
900
]
],
[
[
1121,
1,
887
],
[
887,
1... | [
[
[
"Bisoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium gluconate"
]
],
[
[
"Bisoprolol",
"{u} (Compound) resembles {v} (Compound)",
"Pindolol"
],
[
"Pindolol",
"{u} may cause a mode... | Bisoprolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a moderate interaction that could exacerbate diseases when taken with Calcium gluconate
Bisoprolol may cause a minor interaction that can limit clinical effects when taken with Levothyroxine and Levothyroxine may cause a moderate interaction tha... |
DB00607 | DB12500 | 1,249 | 283 | [
"DDInter1256",
"DDInter714"
] | Nafcillin | Fedratinib | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
1249,
25,
283
]
],
[
[
1249,
24,
466
],
[
466,
62,
283
]
],
[
[
1249,
24,
351
],
[
351,
23,
283
]
],
[
[
1249,
24,
1419
],
[
1419,
... | [
[
[
"Nafcillin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolutami... | Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Riboci... |
DB00451 | DB00612 | 542 | 1,121 | [
"DDInter1064",
"DDInter216"
] | Levothyroxine | Bisoprolol | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-ad... | Minor | 0 | [
[
[
542,
23,
1121
]
],
[
[
542,
23,
819
],
[
819,
40,
1121
]
],
[
[
542,
62,
88
],
[
88,
40,
1121
]
],
[
[
542,
6,
8374
],
[
8374,
4... | [
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Bisoprolol"
]
],
[
[
"Levothyroxine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acebutolol"
],
[
... | Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Acebutolol and Acebutolol (Compound) resembles Bisoprolol (Compound)
Levothyroxine may cause a minor interaction that can limit clinical effects when taken with Metoprolol and Metoprolol (Compound) resembles Bisoprolol (Compound... |
DB00938 | DB01021 | 455 | 674 | [
"DDInter1635",
"DDInter1861"
] | Salmeterol | Trichlormethiazide | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Moderate | 1 | [
[
[
455,
24,
674
]
],
[
[
455,
63,
1014
],
[
1014,
40,
674
]
],
[
[
455,
24,
178
],
[
178,
1,
674
]
],
[
[
455,
18,
2183
],
[
2183,
... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trichlormethiazide"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
]... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Trichlormethiazide (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Polythiazide and Polythiazide (Compound) resembles Trichl... |
DB00374 | DB06810 | 1,061 | 397 | [
"DDInter1852",
"DDInter1484"
] | Treprostinil | Plicamycin | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Moderate | 1 | [
[
[
1061,
24,
397
]
],
[
[
1061,
23,
539
],
[
539,
62,
397
]
],
[
[
1061,
1,
885
],
[
885,
24,
397
]
],
[
[
1061,
24,
1237
],
[
1237,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Plicamycin"
]
],
[
[
"Treprostinil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
... | Treprostinil may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Plicamycin
Treprostinil (Compound) resembles Epoprostenol (Compound) and Epoprostenol may cause a moderate interaction that could... |
DB00549 | DB06414 | 522 | 655 | [
"DDInter1955",
"DDInter703"
] | Zafirlukast | Etravirine | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
522,
24,
655
]
],
[
[
522,
24,
786
],
[
786,
40,
655
]
],
[
[
522,
6,
6017
],
[
6017,
45,
655
]
],
[
[
522,
21,
28680
],
[
28680,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
],
[... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Zafirlukast (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Zafirlukast (Compound) causes Rash (Side Effect) and Rash (Sid... |
DB04837 | DB08883 | 649 | 1,597 | [
"DDInter407",
"DDInter1428"
] | Clofedanol | Perampanel | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
649,
24,
1597
]
],
[
[
649,
63,
100
],
[
100,
24,
1597
]
],
[
[
649,
1,
820
],
[
820,
24,
1597
]
],
[
[
649,
24,
407
],
[
407,
6... | [
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Clofedanol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
],
... | Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine and Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Perampanel
Clofedanol (Compound) resembles Alimemazine (Compound) and Alimemazine may cause a moderate interactio... |
DB00434 | DB00662 | 13 | 717 | [
"DDInter459",
"DDInter1873"
] | Cyproheptadine | Trimethobenzamide | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
13,
24,
717
]
],
[
[
13,
21,
28762
],
[
28762,
60,
717
]
],
[
[
13,
24,
1382
],
[
1382,
63,
717
]
],
[
[
13,
24,
109
],
[
109,
2... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Cyproheptadine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Ef... | Cyproheptadine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Trimethobenzamide (Compound)
Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00987 | DB01041 | 1,224 | 770 | [
"DDInter461",
"DDInter1789"
] | Cytarabine (liposomal) | Thalidomide | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
1224,
37,
770
]
],
[
[
1224,
5,
11555
],
[
11555,
44,
770
]
],
[
[
1224,
7,
7720
],
[
7720,
45,
770
]
],
[
[
1224,
7,
4111
],
[
4111,
... | [
[
[
"Cytarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Thalidomide"
]
],
[
[
"Cytarabine",
"{u} (Compound) treats {v} (Disease)",
"h... | Cytarabine may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Cytarabine may lead to a major life threatening interaction when taken with Thalidomide
Cytarabine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Thalidomide (Compoun... |
DB00708 | DB09472 | 1,454 | 1,383 | [
"DDInter1718",
"DDInter1693"
] | Sufentanil | Sodium sulfate | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1454,
24,
1383
]
],
[
[
1454,
24,
609
],
[
609,
24,
1383
]
],
[
[
1454,
63,
600
],
[
600,
24,
1383
]
],
[
[
1454,
25,
1133
],
[
1133,
... | [
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Sufentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Sufentanil may cause a moderate interaction that could exacerbate diseases when taken with Fluconazo... |
DB00215 | DB00414 | 1,230 | 590 | [
"DDInter388",
"DDInter16"
] | Citalopram | Acetohexamide | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Moderate | 1 | [
[
[
1230,
24,
590
]
],
[
[
1230,
25,
660
],
[
660,
62,
590
]
],
[
[
1230,
24,
1017
],
[
1017,
63,
590
]
],
[
[
1230,
62,
168
],
[
168,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetohexamide"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Esomeprazole"
],
[
"Esome... | Citalopram may lead to a major life threatening interaction when taken with Esomeprazole and Esomeprazole may cause a minor interaction that can limit clinical effects when taken with Acetohexamide
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may c... |
DB06697 | DB12500 | 436 | 283 | [
"DDInter121",
"DDInter714"
] | Artemether | Fedratinib | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
436,
24,
283
]
],
[
[
436,
24,
327
],
[
327,
24,
283
]
],
[
[
436,
64,
932
],
[
932,
24,
283
]
],
[
[
436,
63,
1101
],
[
1101,
2... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
],
[
... | Artemether may cause a moderate interaction that could exacerbate diseases when taken with Abametapir and Abametapir may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib
Artemether may lead to a major life threatening interaction when taken with Mifepristone and Mifepristone may ca... |
DB00059 | DB00580 | 1,560 | 311 | [
"DDInter1404",
"DDInter1910"
] | Pegaspargase | Valdecoxib | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Moderate | 1 | [
[
[
1560,
24,
311
]
],
[
[
1560,
24,
500
],
[
500,
63,
311
]
],
[
[
1560,
24,
663
],
[
663,
24,
311
]
],
[
[
1560,
25,
1510
],
[
1510,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valdecoxib"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enoxaparin"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin and Enoxaparin may cause a moderate interaction that could exacerbate diseases when taken with Valdecoxib
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and ... |
DB00230 | DB00405 | 784 | 128 | [
"DDInter1516",
"DDInter517"
] | Pregabalin | Dexbrompheniramine | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
784,
24,
128
]
],
[
[
784,
24,
662
],
[
662,
63,
128
]
],
[
[
784,
25,
475
],
[
475,
24,
128
]
],
[
[
784,
24,
701
],
[
701,
24,... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Pregabalin may lead to a major life threatening interaction when taken with Morphine and Morphine ... |
DB00544 | DB06168 | 970 | 1,531 | [
"DDInter757",
"DDInter281"
] | Fluorouracil | Canakinumab | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
970,
24,
1531
]
],
[
[
970,
63,
1461
],
[
1461,
23,
1531
]
],
[
[
970,
64,
377
],
[
377,
24,
1531
]
],
[
[
970,
24,
1270
],
[
1270,
... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Fluorouracil may lead to a major life threatening interaction when taken with Mitomycin and Mitomycin may cause a... |
DB00607 | DB00762 | 1,249 | 613 | [
"DDInter1256",
"DDInter973"
] | Nafcillin | Irinotecan | A semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. It is a beta-lactamase-resistant penicillin that is indicated for the treatment of Staphylococcal infections caused by strains that are resistant to other penicillins, except those caused by MRSA. It may be u... | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
1249,
24,
613
]
],
[
[
1249,
6,
8374
],
[
8374,
45,
613
]
],
[
[
1249,
21,
28658
],
[
28658,
60,
613
]
],
[
[
1249,
25,
927
],
[
927,
... | [
[
[
"Nafcillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Nafcillin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Nafcillin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound)
Nafcillin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Irinotecan (Compound)
Nafcillin may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may cause a... |
DB00382 | DB00526 | 62 | 1,555 | [
"DDInter1734",
"DDInter1355"
] | Tacrine | Oxaliplatin | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
62,
24,
1555
]
],
[
[
62,
24,
79
],
[
79,
24,
1555
]
],
[
[
62,
24,
1213
],
[
1213,
63,
1555
]
],
[
[
62,
63,
305
],
[
305,
24,
... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
"S... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may ... |
DB00418 | DB01156 | 536 | 593 | [
"DDInter1650",
"DDInter252"
] | Secobarbital | Bupropion | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
536,
24,
593
]
],
[
[
536,
6,
3486
],
[
3486,
45,
593
]
],
[
[
536,
21,
28952
],
[
28952,
60,
593
]
],
[
[
536,
23,
752
],
[
752,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Secobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Secobarbital (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Bupropion (Compound)
Secobarbital (Compound) causes Nightmare (Side Effect) and Nightmare (Side Effect) is caused by Bupropion (Compound)
Secobarbital may cause a minor interaction that can limit clinical effects when taken with Cimetidine and Ci... |
DB09268 | DB11853 | 1,662 | 230 | [
"DDInter1464",
"DDInter1577"
] | Picosulfuric acid | Relugolix | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
1662,
24,
230
]
],
[
[
1662,
63,
129
],
[
129,
23,
230
]
],
[
[
1662,
63,
79
],
[
79,
24,
230
]
],
[
[
1662,
24,
1297
],
[
1297,
... | [
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Picosulfuric acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
... | Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Picosulfuric acid may cause a moderate interaction that could exacerbate diseases when taken with Sorafe... |
DB00552 | DB09054 | 1,238 | 384 | [
"DDInter1425",
"DDInter905"
] | Pentostatin | Idelalisib | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1238,
24,
384
]
],
[
[
1238,
24,
328
],
[
328,
24,
384
]
],
[
[
1238,
63,
58
],
[
58,
24,
384
]
],
[
[
1238,
24,
287
],
[
287,
6... | [
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Pentostatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mercaptopurine"
],
... | Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Mercaptopurine and Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Pentostatin may cause a moderate interaction that could exacerbate diseases when taken with Alefacept a... |
DB00570 | DB09065 | 147 | 760 | [
"DDInter1936",
"DDInter424"
] | Vinblastine | Cobicistat | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
147,
25,
760
]
],
[
[
147,
63,
1101
],
[
1101,
23,
760
]
],
[
[
147,
24,
555
],
[
555,
23,
760
]
],
[
[
147,
24,
938
],
[
938,
6... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarote... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Netupitant and Netupi... |
DB01169 | DB01324 | 57 | 178 | [
"DDInter120",
"DDInter1490"
] | Arsenic trioxide | Polythiazide | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Major | 2 | [
[
[
57,
25,
178
]
],
[
[
57,
64,
674
],
[
674,
40,
178
]
],
[
[
57,
64,
1264
],
[
1264,
24,
178
]
],
[
[
57,
24,
286
],
[
286,
63,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Polythiazide"
]
],
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trichlormethiazide"
],
[
"Tri... | Arsenic trioxide may lead to a major life threatening interaction when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Arsenic trioxide may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exace... |
DB01261 | DB04946 | 170 | 924 | [
"DDInter1679",
"DDInter907"
] | Sitagliptin | Iloperidone | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
170,
24,
924
]
],
[
[
170,
63,
1664
],
[
1664,
1,
924
]
],
[
[
170,
24,
519
],
[
519,
40,
924
]
],
[
[
170,
6,
8374
],
[
8374,
4... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperidone (... |
DB00889 | DB11642 | 1,133 | 938 | [
"DDInter840",
"DDInter1480"
] | Granisetron | Pitolisant | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
1133,
24,
938
]
],
[
[
1133,
23,
112
],
[
112,
23,
938
]
],
[
[
1133,
24,
28
],
[
28,
24,
938
]
],
[
[
1133,
63,
600
],
[
600,
2... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Granisetron",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Granisetron may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Pitolisant
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Bisacodyl and Bis... |
DB00741 | DB08880 | 167 | 1,510 | [
"DDInter885",
"DDInter1771"
] | Hydrocortisone | Teriflunomide | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
167,
25,
1510
]
],
[
[
167,
62,
1461
],
[
1461,
23,
1510
]
],
[
[
167,
23,
1193
],
[
1193,
62,
1510
]
],
[
[
167,
24,
129
],
[
129,
... | [
[
[
"Hydrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Hydrocortisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vi... | Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and... |
DB01406 | DB08889 | 984 | 350 | [
"DDInter472",
"DDInter299"
] | Danazol | Carfilzomib | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Major | 2 | [
[
[
984,
25,
350
]
],
[
[
984,
21,
28762
],
[
28762,
60,
350
]
],
[
[
984,
63,
482
],
[
482,
24,
350
]
],
[
[
984,
24,
1362
],
[
1362,
... | [
[
[
"Danazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carfilzomib"
]
],
[
[
"Danazol",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Effect) is caused by {v} (Compound)",... | Danazol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Carfilzomib (Compound)
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib
Da... |
DB00536 | DB04843 | 1,225 | 1,511 | [
"DDInter848",
"DDInter1149"
] | Guanidine | Mepenzolate | A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatmen... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
1225,
24,
1511
]
],
[
[
1225,
24,
1192
],
[
1192,
24,
1511
]
],
[
[
1225,
63,
352
],
[
352,
24,
1511
]
],
[
[
1225,
21,
28975
],
[
289... | [
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Guanidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
],
[... | Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Guanidine may cause a moderate interaction that could exacerbate diseases when taken with Trospium and T... |
DB01406 | DB05239 | 984 | 866 | [
"DDInter472",
"DDInter425"
] | Danazol | Cobimetinib | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Moderate | 1 | [
[
[
984,
24,
866
]
],
[
[
984,
24,
1478
],
[
1478,
63,
866
]
],
[
[
984,
63,
482
],
[
482,
24,
866
]
],
[
[
984,
24,
478
],
[
478,
2... | [
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobimetinib"
]
],
[
[
"Danazol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
"I... | Danazol may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Danazol may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine ma... |
DB00258 | DB00279 | 666 | 1,152 | [
"DDInter270",
"DDInter1074"
] | Calcium acetate | Liothyronine | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Moderate | 1 | [
[
[
666,
24,
1152
]
],
[
[
666,
24,
624
],
[
624,
40,
1152
]
],
[
[
666,
21,
29282
],
[
29282,
60,
1152
]
],
[
[
666,
24,
1523
],
[
1523,
... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
]
],
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liotrix"
],... | Calcium acetate may cause a moderate interaction that could exacerbate diseases when taken with Liotrix and Liotrix (Compound) resembles Liothyronine (Compound)
Calcium acetate (Compound) causes Arrhythmia (Side Effect) and Arrhythmia (Side Effect) is caused by Liothyronine (Compound)
Calcium acetate may cause a modera... |
DB00543 | DB00692 | 87 | 274 | [
"DDInter82",
"DDInter1448"
] | Amoxapine | Phentolamine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
87,
24,
274
]
],
[
[
87,
6,
5372
],
[
5372,
45,
274
]
],
[
[
87,
21,
29118
],
[
29118,
60,
274
]
],
[
[
87,
1,
695
],
[
695,
24,... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Amoxapine",
"{u} (Compound) binds {v} (Gene)",
"ADRA2A"
],
[
"ADRA2A",
"{u} (Gene) is bound by {v} (Compound)",... | Amoxapine (Compound) binds ADRA2A (Gene) and ADRA2A (Gene) is bound by Phentolamine (Compound)
Amoxapine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Amoxapine (Compound) resembles Clozapine (Compound) and Clozapine may cause a moderate interaction that ... |
DB00563 | DB08827 | 663 | 990 | [
"DDInter1174",
"DDInter1085"
] | Methotrexate | Lomitapide | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
663,
25,
990
]
],
[
[
663,
6,
4973
],
[
4973,
45,
990
]
],
[
[
663,
21,
28701
],
[
28701,
60,
990
]
],
[
[
663,
24,
1362
],
[
1362,
... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Methotrexate",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Lomit... | Methotrexate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lomitapide (Compound)
Methotrexate (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Lomitapide (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Olaparib and ... |
DB00207 | DB08865 | 1,570 | 1,593 | [
"DDInter157",
"DDInter448"
] | Azithromycin | Crizotinib | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
1570,
25,
1593
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
1570,
7,
9242
],
[
9242,
46,
1593
]
],
[
[
1570,
18,
3627
],
[
3627... | [
[
[
"Azithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Cri... | Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Azithromycin (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Crizotinib (Compound)
Azithromycin (Compound) downregulates BLMH (Gene) and BLMH (Gene) is downregulated by Crizotinib (Compound)
Azithromycin... |
DB00889 | DB01087 | 1,133 | 1,520 | [
"DDInter840",
"DDInter1520"
] | Granisetron | Primaquine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1133,
24,
1520
]
],
[
[
1133,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
1133,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
1133,
21,
28722
],
[
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"... | Granisetron may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Granisetron (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Granisetron (Compound) causes ... |
DB00348 | DB08899 | 254 | 129 | [
"DDInter1300",
"DDInter649"
] | Nitisinone | Enzalutamide | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
254,
24,
129
]
],
[
[
254,
1,
295
],
[
295,
40,
129
]
],
[
[
254,
24,
918
],
[
918,
1,
129
]
],
[
[
254,
21,
28703
],
[
28703,
6... | [
[
[
"Nitisinone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Nitisinone",
"{u} (Compound) resembles {v} (Compound)",
"Nilutamide"
],
[
"Nilutamide",
"{u} (Compound) resemb... | Nitisinone (Compound) resembles Nilutamide (Compound) and Nilutamide (Compound) resembles Enzalutamide (Compound)
Nitisinone may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Nitisinone (Compound) causes Pruritus (S... |
DB00344 | DB00668 | 1,302 | 874 | [
"DDInter1543",
"DDInter652"
] | Protriptyline | Epinephrine | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Epinephrine, also known as _adrenaline_, is a hormone and neurotransmitter and produced by the adrenal glands that can also be used as a drug due to its various important functions. Though it has long been used in the treatment of hypersensitivity reactions, epinephrine in the auto-injector form (EpiPen) has been avail... | Major | 2 | [
[
[
1302,
25,
874
]
],
[
[
1302,
25,
1636
],
[
1636,
1,
874
]
],
[
[
1302,
24,
688
],
[
688,
63,
874
]
],
[
[
1302,
18,
4046
],
[
4046,
... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epinephrine"
]
],
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylephrine"
],
[
"Phenylephrine",... | Protriptyline may lead to a major life threatening interaction when taken with Phenylephrine and Phenylephrine (Compound) resembles Epinephrine (Compound)
Protriptyline may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could e... |
DB09073 | DB11967 | 951 | 710 | [
"DDInter1379",
"DDInter210"
] | Palbociclib | Binimetinib | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Binimetinib, also known as _Mektovi_, is a potent and selective oral mitogen-activated protein kinase 1/2 (MEK 1/2) inhibitor which is combined with [Encorafenib].[A34275,L3335] On June 27, 2018, the Food and Drug Administration approved the combination of [Encorafenib] and binimetinib (BRAFTOVI and MEKTOVI, from Array... | Moderate | 1 | [
[
[
951,
24,
710
]
],
[
[
951,
64,
441
],
[
441,
24,
710
]
],
[
[
951,
63,
1593
],
[
1593,
24,
710
]
],
[
[
951,
25,
68
],
[
68,
63,... | [
[
[
"Palbociclib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Binimetinib"
]
],
[
[
"Palbociclib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delavirdine"
],
[
"Delavi... | Palbociclib may lead to a major life threatening interaction when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Binimetinib
Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may c... |
DB00529 | DB00620 | 789 | 175 | [
"DDInter779",
"DDInter1855"
] | Foscarnet | Triamcinolone | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
789,
24,
175
]
],
[
[
789,
24,
1573
],
[
1573,
1,
175
]
],
[
[
789,
63,
251
],
[
251,
1,
175
]
],
[
[
789,
21,
28762
],
[
28762,
... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[
... | Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Triamcinolone (... |
DB00637 | DB14740 | 1,557 | 771 | [
"DDInter128",
"DDInter881"
] | Astemizole | Hyaluronidase | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permea... | Minor | 0 | [
[
[
1557,
23,
771
]
],
[
[
1557,
63,
252
],
[
252,
23,
771
]
],
[
[
1557,
24,
401
],
[
401,
23,
771
]
],
[
[
1557,
63,
252
],
[
252,
... | [
[
[
"Astemizole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hyaluronidase"
]
],
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[
... | Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine may cause a minor interaction that can limit clinical effects when taken with Hyaluronidase
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and P... |
DB00323 | DB00902 | 1,062 | 104 | [
"DDInter1829",
"DDInter1168"
] | Tolcapone | Methdilazine | Tolcapone is a drug that inhibits the enzyme catechol-O-methyl transferase (COMT). It is used in the treatment of Parkinson's disease as an adjunct to levodopa/carbidopa medication. It is a yellow, odorless, non-hygroscopic, crystalline compound. Tolcapone is associated with a risk of hepatotoxicity. | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1062,
24,
104
]
],
[
[
1062,
24,
13
],
[
13,
24,
104
]
],
[
[
1062,
24,
820
],
[
820,
1,
104
]
],
[
[
1062,
24,
537
],
[
537,
40... | [
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Tolcapone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Tolcapone may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine a... |
DB00196 | DB00802 | 600 | 1,322 | [
"DDInter743",
"DDInter43"
] | Fluconazole | Alfentanil | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Major | 2 | [
[
[
600,
25,
1322
]
],
[
[
600,
25,
704
],
[
704,
1,
1322
]
],
[
[
600,
24,
1454
],
[
1454,
1,
1322
]
],
[
[
600,
6,
6799
],
[
6799,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alfentanil"
]
],
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fentanyl"
],
[
"Fentanyl",
"{u} (Co... | Fluconazole may lead to a major life threatening interaction when taken with Fentanyl and Fentanyl (Compound) resembles Alfentanil (Compound)
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Sufentanil and Sufentanil (Compound) resembles Alfentanil (Compound)
Fluconazole (Comp... |
DB01242 | DB01619 | 1,237 | 830 | [
"DDInter410",
"DDInter1441"
] | Clomipramine | Phenindamine | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1237,
24,
830
]
],
[
[
1237,
63,
537
],
[
537,
40,
830
]
],
[
[
1237,
1,
114
],
[
114,
1,
830
]
],
[
[
1237,
63,
13
],
[
13,
24,... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Clomipramine (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resembles Phenindamine (Compound)
Clomipramine may cause a moderate in... |
DB00468 | DB08875 | 1,424 | 1,618 | [
"DDInter1557",
"DDInter262"
] | Quinine | Cabozantinib | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
1424,
25,
1618
]
],
[
[
1424,
23,
1135
],
[
1135,
62,
1618
]
],
[
[
1424,
23,
112
],
[
112,
23,
1618
]
],
[
[
1424,
24,
723
],
[
723,
... | [
[
[
"Quinine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Quinine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
... | Quinine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Cabozantinib
Quinine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole m... |
DB00353 | DB11901 | 588 | 913 | [
"DDInter1187",
"DDInter107"
] | Methylergometrine | Apalutamide | A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed) | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
588,
24,
913
]
],
[
[
588,
63,
600
],
[
600,
24,
913
]
],
[
[
588,
25,
609
],
[
609,
24,
913
]
],
[
[
588,
24,
1320
],
[
1320,
6... | [
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Methylergometrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"... | Methylergometrine may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Methylergometrine may lead to a major life threatening interaction when taken with Clarithromycin and ... |
DB00582 | DB00912 | 1,622 | 473 | [
"DDInter1946",
"DDInter1581"
] | Voriconazole | Repaglinide | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1622,
24,
473
]
],
[
[
1622,
6,
8374
],
[
8374,
45,
473
]
],
[
[
1622,
21,
28873
],
[
28873,
60,
473
]
],
[
[
1622,
24,
609
],
[
609,
... | [
[
[
"Voriconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Voriconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Voriconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Repaglinide (Compound)
Voriconazole (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Repaglinide (Compound)
Voriconazole may cause a moderate interaction that could exacerbate diseases when taken with Clari... |
DB00342 | DB01087 | 1,181 | 1,520 | [
"DDInter1770",
"DDInter1520"
] | Terfenadine | Primaquine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
1181,
24,
1520
]
],
[
[
1181,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
1181,
23,
112
],
[
112,
23,
1520
]
],
[
[
1181,
24,
479
],
[
479,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],
[
"... | Terfenadine may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may... |
DB00563 | DB00976 | 663 | 1,056 | [
"DDInter1174",
"DDInter1758"
] | Methotrexate | Telithromycin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Telithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the macrolide antibiotics, telithromycin prevents bacterial growth by interfering with ... | Moderate | 1 | [
[
[
663,
24,
1056
]
],
[
[
663,
63,
1570
],
[
1570,
40,
1056
]
],
[
[
663,
21,
28681
],
[
28681,
60,
1056
]
],
[
[
663,
24,
1220
],
[
1220... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telithromycin"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azithromycin"
],... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin and Azithromycin (Compound) resembles Telithromycin (Compound)
Methotrexate (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Telithromycin (Compound)
Methotrexate may... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.