drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00224 | DB00451 | 215 | 542 | [
"DDInter917",
"DDInter1064"
] | Indinavir | Levothyroxine | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
215,
24,
542
]
],
[
[
215,
6,
15333
],
[
15333,
45,
542
]
],
[
[
215,
18,
10375
],
[
10375,
57,
542
]
],
[
[
215,
21,
29291
],
[
29291... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Indinavir",
"{u} (Compound) binds {v} (Gene)",
"SLCO1B1"
],
[
"SLCO1B1",
"{u} (Gene) is bound by {v} (Compound... | Indinavir (Compound) binds SLCO1B1 (Gene) and SLCO1B1 (Gene) is bound by Levothyroxine (Compound)
Indinavir (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Levothyroxine (Compound)
Indinavir (Compound) causes Muscular weakness (Side Effect) and Muscular weakness (Side Effect) is caused by L... |
DB00883 | DB00907 | 426 | 290 | [
"DDInter989",
"DDInter427"
] | Isosorbide dinitrate | Cocaine (topical) | A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
426,
24,
290
]
],
[
[
426,
6,
8374
],
[
8374,
45,
290
]
],
[
[
426,
21,
28658
],
[
28658,
60,
290
]
],
[
[
426,
40,
1107
],
[
1107,
... | [
[
[
"Isosorbide dinitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Isosorbide dinitrate",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by... | Isosorbide dinitrate may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Isosorbide dinitrate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Cocaine (Compound)
Isosorbide dinitrate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Cocaine ... |
DB00375 | DB01070 | 1,037 | 1,098 | [
"DDInter433",
"DDInter558"
] | Colestipol | Dihydrotachysterol | Bile acid sequestrants like colestipol have been in use since the 1970s.[FDA Label, F4555, F4567, L6262] And even though such an agent may very well be useful in reducing elevated cholesterol levels and decreasing the risk for atherosclerotic vascular disease due to hypercholesterolemia, colestipol is still generally o... | A vitamin D that can be regarded as a reduction product of vitamin D2. | Moderate | 1 | [
[
[
1037,
24,
1098
]
],
[
[
1037,
63,
386
],
[
386,
25,
1098
]
],
[
[
1037,
24,
1041
],
[
1041,
25,
1098
]
],
[
[
1037,
24,
1196
],
[
1196... | [
[
[
"Colestipol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dihydrotachysterol"
]
],
[
[
"Colestipol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cholecalciferol"
... | Colestipol may cause a moderate interaction that could exacerbate diseases when taken with Cholecalciferol and Cholecalciferol may lead to a major life threatening interaction when taken with Dihydrotachysterol
Colestipol may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol and P... |
DB00549 | DB00909 | 522 | 306 | [
"DDInter1955",
"DDInter1971"
] | Zafirlukast | Zonisamide | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Moderate | 1 | [
[
[
522,
24,
306
]
],
[
[
522,
6,
8374
],
[
8374,
45,
306
]
],
[
[
522,
21,
28698
],
[
28698,
60,
306
]
],
[
[
522,
24,
159
],
[
159,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zonisamide"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Zonisamide (Compound)
Zafirlukast (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Zonisamide (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and ... |
DB04899 | DB08907 | 1,549 | 1,344 | [
"DDInter1282",
"DDInter280"
] | Nesiritide | Canagliflozin | Nesiritide is a medication used to treat acutely decompensated congestive heart failure with dyspnea at rest or with minimal exertion (such as talk, eating or bathing). Nesiritide is a 32 amino acid recombinant human B-type natriuretic peptide. | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1549,
24,
1344
]
],
[
[
1549,
24,
549
],
[
549,
1,
1344
]
],
[
[
1549,
63,
714
],
[
714,
24,
1344
]
],
[
[
1549,
24,
1455
],
[
1455,
... | [
[
[
"Nesiritide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Nesiritide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
... | Nesiritide may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Nesiritide may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may cause a moderate interaction that ... |
DB00443 | DB00615 | 251 | 690 | [
"DDInter195",
"DDInter1589"
] | Betamethasone | Rifabutin | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Moderate | 1 | [
[
[
251,
24,
690
]
],
[
[
251,
24,
463
],
[
463,
1,
690
]
],
[
[
251,
6,
8374
],
[
8374,
45,
690
]
],
[
[
251,
7,
3727
],
[
3727,
46... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
]
],
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
],
... | Betamethasone may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampicin (Compound) resembles Rifabutin (Compound)
Betamethasone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rifabutin (Compound)
Betamethasone (Compound) upregulates MAL (Gene) and MAL (Gene)... |
DB01381 | DB08899 | 958 | 129 | [
"DDInter819",
"DDInter649"
] | Ginkgo biloba | Enzalutamide | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
958,
24,
129
]
],
[
[
958,
63,
608
],
[
608,
23,
129
]
],
[
[
958,
63,
1010
],
[
1010,
24,
129
]
],
[
[
958,
24,
498
],
[
498,
6... | [
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Ginkgo biloba",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
... | Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Enzalutamide
Ginkgo biloba may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and Me... |
DB00188 | DB15091 | 168 | 676 | [
"DDInter222",
"DDInter1901"
] | Bortezomib | Upadacitinib | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
168,
25,
676
]
],
[
[
168,
63,
1461
],
[
1461,
23,
676
]
],
[
[
168,
24,
1430
],
[
1430,
24,
676
]
],
[
[
168,
23,
1249
],
[
1249,
... | [
[
[
"Bortezomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Upadacitinib
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipule... |
DB00773 | DB09118 | 896 | 1,580 | [
"DDInter702",
"DDInter1711"
] | Etoposide | Stiripentol | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
896,
24,
1580
]
],
[
[
896,
24,
283
],
[
283,
63,
1580
]
],
[
[
896,
63,
168
],
[
168,
24,
1580
]
],
[
[
896,
24,
1532
],
[
1532,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezo... |
DB00095 | DB08904 | 66 | 375 | [
"DDInter623",
"DDInter342"
] | Efalizumab | Certolizumab pegol | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Moderate | 1 | [
[
[
66,
24,
375
]
],
[
[
66,
23,
1461
],
[
1461,
23,
375
]
],
[
[
66,
23,
1193
],
[
1193,
62,
375
]
],
[
[
66,
24,
1367
],
[
1367,
6... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Certolizumab pegol"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
... | Efalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Certolizumab pegol
Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zi... |
DB00761 | DB00939 | 1,621 | 1,338 | [
"DDInter1497",
"DDInter1135"
] | Potassium chloride | Meclofenamic acid | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Moderate | 1 | [
[
[
1621,
24,
1338
]
],
[
[
1621,
21,
28900
],
[
28900,
60,
1338
]
],
[
[
1621,
63,
1274
],
[
1274,
24,
1338
]
],
[
[
1621,
24,
848
],
[
8... | [
[
[
"Potassium chloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meclofenamic acid"
]
],
[
[
"Potassium chloride",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",... | Potassium chloride (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Meclofenamic acid (Compound)
Potassium chloride may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacer... |
DB09074 | DB12010 | 1,362 | 214 | [
"DDInter1327",
"DDInter785"
] | Olaparib | Fostamatinib | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1362,
24,
214
]
],
[
[
1362,
64,
976
],
[
976,
24,
214
]
],
[
[
1362,
24,
861
],
[
861,
63,
214
]
],
[
[
1362,
63,
866
],
[
866,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
"Tofacitinib... | Olaparib may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib and Ripretinib may cause ... |
DB00350 | DB00831 | 1,214 | 1,178 | [
"DDInter1226",
"DDInter1866"
] | Minoxidil | Trifluoperazine | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Moderate | 1 | [
[
[
1214,
24,
1178
]
],
[
[
1214,
24,
695
],
[
695,
40,
1178
]
],
[
[
1214,
24,
9
],
[
9,
1,
1178
]
],
[
[
1214,
24,
1376
],
[
1376,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Trifluoperazine (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine (Compound) resembles Trifluo... |
DB00347 | DB01069 | 917 | 401 | [
"DDInter1871",
"DDInter1533"
] | Trimethadione | Promethazine | An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378) | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
917,
24,
401
]
],
[
[
917,
24,
1264
],
[
1264,
63,
401
]
],
[
[
917,
6,
6017
],
[
6017,
45,
401
]
],
[
[
917,
21,
28709
],
[
28709,
... | [
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Trimethadione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
... | Trimethadione may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Trimethadione (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Promethazine (Compound)
Trimethadione ... |
DB09075 | DB11689 | 498 | 321 | [
"DDInter621",
"DDInter1659"
] | Edoxaban | Selumetinib | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Moderate | 1 | [
[
[
498,
24,
321
]
],
[
[
498,
24,
298
],
[
298,
24,
321
]
],
[
[
498,
64,
291
],
[
291,
24,
321
]
],
[
[
498,
25,
1421
],
[
1421,
6... | [
[
[
"Edoxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
]
],
[
[
"Edoxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
],
[
... | Edoxaban may cause a moderate interaction that could exacerbate diseases when taken with Protein C and Protein C may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Edoxaban may lead to a major life threatening interaction when taken with Argatroban and Argatroban may cause a mod... |
DB00916 | DB06589 | 112 | 1,250 | [
"DDInter1202",
"DDInter1400"
] | Metronidazole | Pazopanib | Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics. It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A181039] Metronidazole has been used as an antibiotic for several ... | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Minor | 0 | [
[
[
112,
23,
1250
]
],
[
[
112,
6,
3486
],
[
3486,
45,
1250
]
],
[
[
112,
21,
28868
],
[
28868,
60,
1250
]
],
[
[
112,
23,
1247
],
[
1247,... | [
[
[
"Metronidazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Pazopanib"
]
],
[
[
"Metronidazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Metronidazole (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Pazopanib (Compound)
Metronidazole (Compound) causes Stomatitis (Side Effect) and Stomatitis (Side Effect) is caused by Pazopanib (Compound)
Metronidazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxa... |
DB01168 | DB01452 | 1,053 | 993 | [
"DDInter1526",
"DDInter532"
] | Procarbazine | Diamorphine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Diamorphine (heroin) is a narcotic analgesic that may be habit-forming. It is a controlled substance (opium derivative) listed in the U.S. Code of Federal Regulations, Title 21 Parts 329.1, 1308.11 (1987). Sale is forbidden in the United States by Federal statute. (Merck Index, 11th ed) Internationally, diamorphine is ... | Major | 2 | [
[
[
1053,
25,
993
]
],
[
[
1053,
64,
421
],
[
421,
40,
993
]
],
[
[
1053,
64,
475
],
[
475,
25,
993
]
],
[
[
1053,
25,
22
],
[
22,
2... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diamorphine"
]
],
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydromorphone"
],
[
"Hydromorphone",
... | Procarbazine may lead to a major life threatening interaction when taken with Hydromorphone and Hydromorphone (Compound) resembles Diamorphine (Compound)
Procarbazine may lead to a major life threatening interaction when taken with Morphine and Morphine may lead to a major life threatening interaction when taken with D... |
DB00909 | DB11901 | 306 | 913 | [
"DDInter1971",
"DDInter107"
] | Zonisamide | Apalutamide | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
306,
24,
913
]
],
[
[
306,
63,
600
],
[
600,
24,
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]
],
[
[
306,
24,
609
],
[
609,
24,
913
]
],
[
[
306,
24,
1619
],
[
1619,
6... | [
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Zonisamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Zonisamide may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and... |
DB00023 | DB00624 | 305 | 1,561 | [
"DDInter127",
"DDInter1775"
] | Asparaginase Escherichia coli | Testosterone | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
305,
24,
1561
]
],
[
[
305,
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155
],
[
155,
1,
1561
]
],
[
[
305,
24,
1026
],
[
1026,
40,
1561
]
],
[
[
305,
24,
891
],
[
891,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Fluoxymesterone and Fluoxymesterone (Compound) resembles Testosterone (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Oxandrolone and Oxa... |
DB00039 | DB00570 | 1,253 | 147 | [
"DDInter1380",
"DDInter1936"
] | Palifermin | Vinblastine | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
1253,
24,
147
]
],
[
[
1253,
24,
134
],
[
134,
24,
147
]
],
[
[
1253,
24,
970
],
[
970,
23,
147
]
],
[
[
1253,
24,
37
],
[
37,
6... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Fluorouracil and F... |
DB08882 | DB12147 | 1,281 | 241 | [
"DDInter1070",
"DDInter661"
] | Linagliptin | Erdafitinib | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes. Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin w... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
1281,
24,
241
]
],
[
[
1281,
24,
982
],
[
982,
63,
241
]
],
[
[
1281,
63,
850
],
[
850,
24,
241
]
],
[
[
1281,
63,
1220
],
[
1220,
... | [
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Linagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
],
[... | Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Linagliptin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedoti... |
DB00704 | DB06210 | 267 | 72 | [
"DDInter1263",
"DDInter631"
] | Naltrexone | Eltrombopag | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Eltrombopag is used to treat low blood platelet counts in adults with chronic immune (idiopathic) thrombocytopenia (ITP), when certain other medicines, or surgery to remove the spleen, have not worked well enough. ITP is a condition that may cause unusual bruising or bleeding due to an abnormally low number of platelet... | Moderate | 1 | [
[
[
267,
24,
72
]
],
[
[
267,
6,
15705
],
[
15705,
45,
72
]
],
[
[
267,
24,
384
],
[
384,
63,
72
]
],
[
[
267,
63,
467
],
[
467,
24,... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
]
],
[
[
"Naltrexone",
"{u} (Compound) binds {v} (Gene)",
"UGT1A1"
],
[
"UGT1A1",
"{u} (Gene) is bound by {v} (Compound)"... | Naltrexone (Compound) binds UGT1A1 (Gene) and UGT1A1 (Gene) is bound by Eltrombopag (Compound)
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag
Naltrexone may c... |
DB00372 | DB01114 | 999 | 272 | [
"DDInter1793",
"DDInter362"
] | Thiethylperazine | Chlorpheniramine | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
999,
24,
272
]
],
[
[
999,
24,
358
],
[
358,
63,
272
]
],
[
[
999,
24,
128
],
[
128,
24,
272
]
],
[
[
999,
63,
1242
],
[
1242,
2... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadr... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00939 | DB00959 | 1,338 | 1,486 | [
"DDInter1135",
"DDInter1191"
] | Meclofenamic acid | Methylprednisolone | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
1338,
24,
1486
]
],
[
[
1338,
63,
175
],
[
175,
40,
1486
]
],
[
[
1338,
63,
167
],
[
167,
1,
1486
]
],
[
[
1338,
24,
1220
],
[
1220,
... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triam... | Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compou... |
DB00795 | DB09420 | 50 | 1,074 | [
"DDInter1725",
"DDInter953"
] | Sulfasalazine | Iodide I-123 | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
50,
24,
1074
]
],
[
[
50,
40,
161
],
[
161,
24,
1074
]
],
[
[
50,
64,
126
],
[
126,
24,
1074
]
],
[
[
50,
25,
777
],
[
777,
24,
... | [
[
[
"Sulfasalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Sulfasalazine",
"{u} (Compound) resembles {v} (Compound)",
"Sulfadiazine"
],
[
"Sulfadiazine",
"{u} may cau... | Sulfasalazine (Compound) resembles Sulfadiazine (Compound) and Sulfadiazine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Sulfasalazine may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could exacer... |
DB06650 | DB10316 | 1,500 | 334 | [
"DDInter1324",
"DDInter1248"
] | Ofatumumab | Mumps virus strain B level jeryl lynn live antigen | Ofatumumab is a novel anti-CD20 monoclonal antibody that targets B-cells. It is an IgG1κ human monoclonal antibody produced from a recombinant murine cell line (NS0) via transgenic mouse and hybridoma technology. Ofatumumab works by recognizing antigens that are expressed on the tumour cells in certain cancers; however... | Mumps virus strain B level jeryl lynn live antigen is a live attenuated virus vaccine for subcutenous injection. It is an active immunization against mumps, which is a common childhood disease. | Major | 2 | [
[
[
1500,
25,
334
]
],
[
[
1500,
64,
1057
],
[
1057,
25,
334
]
],
[
[
1500,
25,
908
],
[
908,
25,
334
]
],
[
[
1500,
63,
599
],
[
599,
... | [
[
[
"Ofatumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mumps virus strain B level jeryl lynn live antigen"
]
],
[
[
"Ofatumumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"
]... | Ofatumumab may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Mumps virus strain B level jeryl lynn live antigen
Ofatumumab may lead to a major life threatening interaction when taken with Golimumab and Golimumab ma... |
DB00734 | DB01218 | 1,664 | 1,493 | [
"DDInter1605",
"DDInter852"
] | Risperidone | Halofantrine | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
1664,
25,
1493
]
],
[
[
1664,
6,
12523
],
[
12523,
45,
1493
]
],
[
[
1664,
21,
28810
],
[
28810,
60,
1493
]
],
[
[
1664,
23,
112
],
[
... | [
[
[
"Risperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Risperidone",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Hal... | Risperidone (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Halofantrine (Compound)
Risperidone (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Halofantrine (Compound)
Risperidone may cause a minor interaction that can limit clinical effects when t... |
DB01166 | DB01254 | 477 | 1,213 | [
"DDInter379",
"DDInter484"
] | Cilostazol | Dasatinib | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
477,
25,
1213
]
],
[
[
477,
6,
8374
],
[
8374,
45,
1213
]
],
[
[
477,
7,
3422
],
[
3422,
46,
1213
]
],
[
[
477,
18,
4303
],
[
4303,
... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Cilostazol",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Dasatini... | Cilostazol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dasatinib (Compound)
Cilostazol (Compound) upregulates SATB1 (Gene) and SATB1 (Gene) is upregulated by Dasatinib (Compound)
Cilostazol (Compound) downregulates CLTB (Gene) and CLTB (Gene) is downregulated by Dasatinib (Compound)
Cilostazol (Compoun... |
DB01169 | DB01177 | 57 | 77 | [
"DDInter120",
"DDInter904"
] | Arsenic trioxide | Idarubicin | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
57,
25,
77
]
],
[
[
57,
6,
2067
],
[
2067,
46,
77
]
],
[
[
57,
6,
3517
],
[
3517,
57,
77
]
],
[
[
57,
64,
739
],
[
739,
23,
... | [
[
[
"Arsenic trioxide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Arsenic trioxide",
"{u} (Compound) binds {v} (Gene)",
"IKBKB"
],
[
"IKBKB",
"{u} (Gene) is upregulated by {v} (Compound)"... | Arsenic trioxide (Compound) binds IKBKB (Gene) and IKBKB (Gene) is upregulated by Idarubicin (Compound)
Arsenic trioxide (Compound) binds TXNRD1 (Gene) and TXNRD1 (Gene) is downregulated by Idarubicin (Compound)
Arsenic trioxide may lead to a major life threatening interaction when taken with Lomefloxacin and Lomefloxa... |
DB00855 | DB05239 | 213 | 866 | [
"DDInter72",
"DDInter425"
] | Aminolevulinic acid | Cobimetinib | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
213,
25,
866
]
],
[
[
213,
25,
33
],
[
33,
24,
866
]
],
[
[
213,
25,
785
],
[
785,
63,
866
]
],
[
[
213,
36,
842
],
[
842,
24,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amiodarone"
],
[
"Amioda... | Aminolevulinic acid may lead to a major life threatening interaction when taken with Amiodarone and Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Aminolevulinic acid may lead to a major life threatening interaction when taken with Capmatinib and Capmatinib may ca... |
DB01115 | DB08865 | 336 | 1,593 | [
"DDInter1291",
"DDInter448"
] | Nifedipine | Crizotinib | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Moderate | 1 | [
[
[
336,
24,
1593
]
],
[
[
336,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
336,
18,
8992
],
[
8992,
46,
1593
]
],
[
[
336,
7,
8386
],
[
8386,
... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]
],
[
[
"Nifedipine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Nifedipine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Nifedipine (Compound) downregulates GLRX (Gene) and GLRX (Gene) is upregulated by Crizotinib (Compound)
Nifedipine (Compound) upregulates MTHFD2 (Gene) and MTHFD2 (Gene) is downregulated by Crizotinib (Compound)
Nifedipine (Co... |
DB00387 | DB00405 | 1,386 | 128 | [
"DDInter1528",
"DDInter517"
] | Procyclidine | Dexbrompheniramine | A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism. | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Moderate | 1 | [
[
[
1386,
24,
128
]
],
[
[
1386,
24,
662
],
[
662,
63,
128
]
],
[
[
1386,
63,
1089
],
[
1089,
24,
128
]
],
[
[
1386,
40,
456
],
[
456,
... | [
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexbrompheniramine"
]
],
[
[
"Procyclidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
... | Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniramine
Procyclidine may cause a moderate interaction that could exacerbate diseases when taken with Ipr... |
DB00563 | DB00675 | 663 | 888 | [
"DDInter1174",
"DDInter1744"
] | Methotrexate | Tamoxifen | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
663,
24,
888
]
],
[
[
663,
5,
11579
],
[
11579,
44,
888
]
],
[
[
663,
6,
4973
],
[
4973,
45,
888
]
],
[
[
663,
7,
10248
],
[
10248,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Methotrexate",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is t... | Methotrexate (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Tamoxifen (Compound)
Methotrexate (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Tamoxifen (Compound)
Methotrexate (Compound) upregulates FAM63A (Gene) and FAM63A (Gene) is upregulated by Tamoxifen (Compound)
Me... |
DB00526 | DB01229 | 1,555 | 973 | [
"DDInter1355",
"DDInter1378"
] | Oxaliplatin | Paclitaxel (protein-bound) | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
1555,
24,
973
]
],
[
[
1555,
24,
310
],
[
310,
63,
973
]
],
[
[
1555,
6,
5912
],
[
5912,
45,
973
]
],
[
[
1555,
25,
945
],
[
945,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Oxalip... |
DB01377 | DB09104 | 1,283 | 286 | [
"DDInter1119",
"DDInter1118"
] | Magnesium oxide | Magnesium hydroxide | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1283,
24,
286
]
],
[
[
1283,
23,
481
],
[
481,
23,
286
]
],
[
[
1283,
62,
820
],
[
820,
23,
286
]
],
[
[
1283,
63,
633
],
[
633,
... | [
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Magnesium oxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Quazepam"
... | Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Quazepam and Quazepam may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Magnesium oxide may cause a minor interaction that can limit clinical effects when taken with Alimemazine ... |
DB00006 | DB06186 | 942 | 1,439 | [
"DDInter217",
"DDInter969"
] | Bivalirudin | Ipilimumab | Bivalirudin is a synthetic 20 residue peptide (thrombin inhibitor) which reversibly inhibits thrombin. Once bound to the active site, thrombin cannot activate fibrinogen into fibrin, the crucial step in the formation of thrombus. It is administered intravenously. Because it can cause blood stagnation, it is important t... | Ipilimumab is a fully humanized IgG1 monoclonal antibody that blocks cytotoxic T lymphocyte antigen-4 (CTLA-4). Blocking CTLA-4 removes an inhibitory signal from reducing the activity of T lymphocytes.[A35065,A35080,L12126] Ipilimumab was developed by Bristol-Myers Squibb and Medarex. Ipilimumab was granted FDA approva... | Major | 2 | [
[
[
942,
25,
1439
]
],
[
[
942,
25,
1468
],
[
1468,
63,
1439
]
],
[
[
942,
25,
4
],
[
4,
24,
1439
]
],
[
[
942,
25,
1409
],
[
1409,
... | [
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ipilimumab"
]
],
[
[
"Bivalirudin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
],
[
"Ponatinib",
"{u} m... | Bivalirudin may lead to a major life threatening interaction when taken with Ponatinib and Ponatinib may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab
Bivalirudin may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesucci... |
DB00539 | DB06448 | 11 | 171 | [
"DDInter1837",
"DDInter1087"
] | Toremifene | Lonafarnib | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Major | 2 | [
[
[
11,
25,
171
]
],
[
[
11,
36,
888
],
[
888,
24,
171
]
],
[
[
11,
23,
112
],
[
112,
24,
171
]
],
[
[
11,
64,
1424
],
[
1424,
24,
... | [
[
[
"Toremifene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lonafarnib"
]
],
[
[
"Toremifene",
"{u} (Compound) resembles {v} (Compound) and {u} may lead to a major life threatening interaction when taken with {v}",
"Tamoxifen"
... | Toremifene (Compound) resembles Tamoxifen (Compound) and Toremifene may lead to a major life threatening interaction when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Toremifene may cause a minor interaction that can limit clinical effects... |
DB00810 | DB11130 | 456 | 407 | [
"DDInter211",
"DDInter1344"
] | Biperiden | Opium | A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine. | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
456,
24,
407
]
],
[
[
456,
63,
662
],
[
662,
24,
407
]
],
[
[
456,
24,
104
],
[
104,
24,
407
]
],
[
[
456,
1,
1386
],
[
1386,
24... | [
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Biperiden",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Biperiden may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methd... |
DB01133 | DB06792 | 1,104 | 1,606 | [
"DDInter1808",
"DDInter1023"
] | Tiludronic acid | Lanthanum carbonate | Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to [etidronic acid] and [clodronic acid].[A1923,A203111] These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. Tiludronic acid was first described ... | Lanthanum carbonate is a phosphate binder commonly used in clinical practice. It is marketed under the trade name _Fosrenol_ by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led... | Moderate | 1 | [
[
[
1104,
24,
1606
]
],
[
[
1104,
24,
428
],
[
428,
63,
1606
]
],
[
[
1104,
24,
1596
],
[
1596,
24,
1606
]
],
[
[
1104,
24,
428
],
[
428,
... | [
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lanthanum carbonate"
]
],
[
[
"Tiludronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ferrous ... | Tiludronic acid may cause a moderate interaction that could exacerbate diseases when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when taken with Lanthanum carbonate
Tiludronic acid may cause a moderate interaction that could exacerbate diseases when t... |
DB00023 | DB01261 | 305 | 170 | [
"DDInter127",
"DDInter1679"
] | Asparaginase Escherichia coli | Sitagliptin | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
305,
24,
170
]
],
[
[
305,
24,
52
],
[
52,
62,
170
]
],
[
[
305,
24,
1638
],
[
1638,
24,
170
]
],
[
[
305,
24,
1154
],
[
1154,
6... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and Dulaglutide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate disease... |
DB01211 | DB01319 | 609 | 34 | [
"DDInter393",
"DDInter777"
] | Clarithromycin | Fosamprenavir | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Minor | 0 | [
[
[
609,
23,
34
]
],
[
[
609,
62,
1091
],
[
1091,
40,
34
]
],
[
[
609,
6,
8374
],
[
8374,
45,
34
]
],
[
[
609,
21,
29062
],
[
29062,
... | [
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Clarithromycin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amprenavir"
],
... | Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Clarithromycin (Compound) causes Neutropenia (Side Eff... |
DB00959 | DB04868 | 1,486 | 478 | [
"DDInter1191",
"DDInter1293"
] | Methylprednisolone | Nilotinib | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1486,
24,
478
]
],
[
[
1486,
10,
11555
],
[
11555,
44,
478
]
],
[
[
1486,
6,
4973
],
[
4973,
45,
478
]
],
[
[
1486,
18,
5057
],
[
5057... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) palliates {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
... | Methylprednisolone (Compound) palliates hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Nilotinib (Compound)
Methylprednisolone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Methylprednisolone (Compound) downregulates IL1B (Gene) and IL1B (Gene) is upregulat... |
DB01030 | DB01101 | 869 | 60 | [
"DDInter1835",
"DDInter285"
] | Topotecan | Capecitabine | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
869,
24,
60
]
],
[
[
869,
7,
5182
],
[
5182,
45,
60
]
],
[
[
869,
7,
6952
],
[
6952,
46,
60
]
],
[
[
869,
21,
28701
],
[
28701,
... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Topotecan",
"{u} (Compound) upregulates {v} (Gene)",
"CES1"
],
[
"CES1",
"{u} (Gene) is bound by {v} (Compound)... | Topotecan (Compound) upregulates CES1 (Gene) and CES1 (Gene) is bound by Capecitabine (Compound)
Topotecan (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Capecitabine (Compound)
Topotecan (Compound) causes Discomfort (Side Effect) and Discomfort (Side Effect) is caused by Capecitabine (Compoun... |
DB00490 | DB06691 | 946 | 849 | [
"DDInter254",
"DDInter1155"
] | Buspirone | Mepyramine | Buspirone is a novel anxiolytic agent with a unique structure and a pharmacological profile. Belonging to the azaspirodecanedione drug class, buspirone is a serotonin 5-HT<sub>1A</sub> receptor agonist that is not chemically or pharmacologically related to benzodiazepines, barbiturates, and other sedative/anxiolytic dr... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
946,
24,
849
]
],
[
[
946,
63,
1594
],
[
1594,
24,
849
]
],
[
[
946,
24,
272
],
[
272,
24,
849
]
],
[
[
946,
6,
12523
],
[
12523,
... | [
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Buspirone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Buspirone may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine and Ch... |
DB00621 | DB01125 | 1,026 | 279 | [
"DDInter1357",
"DDInter98"
] | Oxandrolone | Anisindione | A synthetic hormone with anabolic and androgenic properties. | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Major | 2 | [
[
[
1026,
25,
279
]
],
[
[
1026,
63,
175
],
[
175,
24,
279
]
],
[
[
1026,
24,
1220
],
[
1220,
63,
279
]
],
[
[
1026,
24,
1411
],
[
1411,
... | [
[
[
"Oxandrolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Anisindione"
]
],
[
[
"Oxandrolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
[
"Tria... | Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Anisindione
Oxandrolone may cause a moderate interaction that could exacerbate diseases when taken with Dexamethason... |
DB01191 | DB04932 | 1,039 | 1,564 | [
"DDInter518",
"DDInter491"
] | Dexfenfluramine | Defibrotide | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
1039,
24,
1564
]
],
[
[
1039,
63,
914
],
[
914,
24,
1564
]
],
[
[
1039,
64,
1100
],
[
1100,
24,
1564
]
],
[
[
1039,
25,
41
],
[
41,
... | [
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Dexfenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diflunisal"
... | Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisal may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Dexfenfluramine may lead to a major life threatening interaction when taken with Venlafaxine and Venlafaxi... |
DB00262 | DB06674 | 552 | 908 | [
"DDInter302",
"DDInter837"
] | Carmustine | Golimumab | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
552,
25,
908
]
],
[
[
552,
63,
1461
],
[
1461,
23,
908
]
],
[
[
552,
24,
697
],
[
697,
24,
908
]
],
[
[
552,
24,
200
],
[
200,
6... | [
[
[
"Carmustine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Carmustine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Golimumab
Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobar... |
DB00862 | DB01001 | 1,005 | 688 | [
"DDInter1918",
"DDInter1632"
] | Vardenafil | Salbutamol | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. It is 29 times more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart. Salbutamol is formu... | Moderate | 1 | [
[
[
1005,
24,
688
]
],
[
[
1005,
24,
455
],
[
455,
24,
688
]
],
[
[
1005,
24,
1148
],
[
1148,
63,
688
]
],
[
[
1005,
6,
8374
],
[
8374,
... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
]
],
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
... | Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isop... |
DB00736 | DB00745 | 660 | 307 | [
"DDInter676",
"DDInter1236"
] | Esomeprazole | Modafinil | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron ac... | Moderate | 1 | [
[
[
660,
24,
307
]
],
[
[
660,
63,
362
],
[
362,
40,
307
]
],
[
[
660,
24,
1335
],
[
1335,
40,
307
]
],
[
[
660,
6,
10215
],
[
10215,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
[
... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Modafinil (Compound)
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Oxcarbazepine and Oxcarbazepine (Compound) resembles Modafinil (Comp... |
DB00400 | DB00990 | 353 | 1,547 | [
"DDInter843",
"DDInter705"
] | Griseofulvin | Exemestane | An antifungal antibiotic. Griseofulvin may be given by mouth in the treatment of tinea infections. | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Moderate | 1 | [
[
[
353,
24,
1547
]
],
[
[
353,
63,
380
],
[
380,
24,
1547
]
],
[
[
353,
24,
559
],
[
559,
24,
1547
]
],
[
[
353,
6,
8374
],
[
8374,
... | [
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exemestane"
]
],
[
[
"Griseofulvin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conjugated estrogens"
... | Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken with Conjugated estrogens and Conjugated estrogens may cause a moderate interaction that could exacerbate diseases when taken with Exemestane
Griseofulvin may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00860 | DB00881 | 891 | 954 | [
"DDInter1513",
"DDInter1554"
] | Prednisolone | Quinapril | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Moderate | 1 | [
[
[
891,
24,
954
]
],
[
[
891,
63,
1638
],
[
1638,
1,
954
]
],
[
[
891,
63,
1523
],
[
1523,
40,
954
]
],
[
[
891,
21,
28644
],
[
28644,
... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
]
],
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
],
... | Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Trandolapril and Trandolapril (Compound) resembles Quinapril (Compound)
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Labetalol and Labetalol (Compound) resembles Quinapril (Compou... |
DB01041 | DB01073 | 770 | 1,488 | [
"DDInter1789",
"DDInter745"
] | Thalidomide | Fludarabine | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Major | 2 | [
[
[
770,
25,
1488
]
],
[
[
770,
64,
1426
],
[
1426,
1,
1488
]
],
[
[
770,
5,
11555
],
[
11555,
44,
1488
]
],
[
[
770,
21,
28701
],
[
28701... | [
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fludarabine"
]
],
[
[
"Thalidomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Azacitidine"
],
[
"Azacitidine",
"... | Thalidomide may lead to a major life threatening interaction when taken with Azacitidine and Azacitidine (Compound) resembles Fludarabine (Compound)
Thalidomide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Fludarabine (Compound)
Thalidomide (Compound) causes Discomfort (... |
DB00641 | DB12015 | 467 | 1,033 | [
"DDInter1675",
"DDInter53"
] | Simvastatin | Alpelisib | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
467,
24,
1033
]
],
[
[
467,
24,
951
],
[
951,
24,
1033
]
],
[
[
467,
63,
10
],
[
10,
24,
1033
]
],
[
[
467,
25,
1510
],
[
1510,
... | [
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Simvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Palbociclib"
],
[
... | Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib and Palbociclib may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib
Simvastatin may cause a moderate interaction that could exacerbate diseases when taken with Dapsone and Dapson... |
DB00379 | DB05812 | 143 | 1,374 | [
"DDInter1206",
"DDInter8"
] | Mexiletine | Abiraterone | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Moderate | 1 | [
[
[
143,
24,
1374
]
],
[
[
143,
6,
12523
],
[
12523,
45,
1374
]
],
[
[
143,
21,
28809
],
[
28809,
60,
1374
]
],
[
[
143,
24,
760
],
[
760,... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
]
],
[
[
"Mexiletine",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)"... | Mexiletine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Abiraterone (Compound)
Mexiletine (Compound) causes Diarrhoea (Side Effect) and Diarrhoea (Side Effect) is caused by Abiraterone (Compound)
Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Co... |
DB00019 | DB01101 | 1,257 | 60 | [
"DDInter1405",
"DDInter285"
] | Pegfilgrastim | Capecitabine | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Moderate | 1 | [
[
[
1257,
24,
60
]
],
[
[
1257,
24,
309
],
[
309,
62,
60
]
],
[
[
1257,
24,
147
],
[
147,
23,
60
]
],
[
[
1257,
24,
599
],
[
599,
24... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Capecitabine"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
],... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabepilone may cause a minor interaction that can limit clinical effects when taken with Capecitabine
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine a... |
DB00843 | DB09073 | 479 | 951 | [
"DDInter583",
"DDInter1379"
] | Donepezil | Palbociclib | In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990. Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and i... | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Minor | 0 | [
[
[
479,
23,
951
]
],
[
[
479,
24,
1476
],
[
1476,
63,
951
]
],
[
[
479,
23,
159
],
[
159,
63,
951
]
],
[
[
479,
62,
600
],
[
600,
2... | [
[
[
"Donepezil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Palbociclib"
]
],
[
[
"Donepezil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
],
[
... | Donepezil may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Donepezil may cause a minor interaction that can limit clinical effects when taken with Larotrectinib and Larotr... |
DB00331 | DB01224 | 1,645 | 623 | [
"DDInter1164",
"DDInter1553"
] | Metformin | Quetiapine | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Moderate | 1 | [
[
[
1645,
24,
623
]
],
[
[
1645,
24,
695
],
[
695,
1,
623
]
],
[
[
1645,
18,
4729
],
[
4729,
57,
623
]
],
[
[
1645,
21,
29272
],
[
29272,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clozapine"
],
[
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Clozapine and Clozapine (Compound) resembles Quetiapine (Compound)
Metformin (Compound) downregulates EBNA1BP2 (Gene) and EBNA1BP2 (Gene) is downregulated by Quetiapine (Compound)
Metformin (Compound) causes Accidental injury (Sid... |
DB00911 | DB05773 | 458 | 1,047 | [
"DDInter1811",
"DDInter1848"
] | Tinidazole | Trastuzumab emtansine | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Trastuzumab emtansine, formerly called Trastuzumab-DM1 (T-DM1) is a first-in-class HER2 antibody drug conjugate (ADC) comprised of Genentech's trastuzumab antibody linked to ImmunoGen's cell-killing agent, DM1. T-DM1 combines two strategies-- anti-HER2 activity and targeted intracellular delivery of the potent anti-mic... | Moderate | 1 | [
[
[
458,
24,
1047
]
],
[
[
458,
64,
1091
],
[
1091,
24,
1047
]
],
[
[
458,
24,
375
],
[
375,
63,
1047
]
],
[
[
458,
24,
1112
],
[
1112,
... | [
[
[
"Tinidazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trastuzumab emtansine"
]
],
[
[
"Tinidazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amprenavir"
],
[
... | Tinidazole may lead to a major life threatening interaction when taken with Amprenavir and Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Trastuzumab emtansine
Tinidazole may cause a moderate interaction that could exacerbate diseases when taken with Certolizumab pegol and Ce... |
DB09065 | DB12267 | 760 | 1,476 | [
"DDInter424",
"DDInter233"
] | Cobicistat | Brigatinib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
760,
25,
1476
]
],
[
[
760,
24,
1612
],
[
1612,
23,
1476
]
],
[
[
760,
64,
1135
],
[
1135,
23,
1476
]
],
[
[
760,
63,
168
],
[
168,
... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostemsavir"
],
[
"Fostemsav... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Fostemsavir may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Cobicistat may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a ... |
DB06772 | DB09498 | 310 | 810 | [
"DDInter259",
"DDInter1715"
] | Cabazitaxel | Strontium chloride Sr-89 | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
310,
24,
810
]
],
[
[
310,
63,
1555
],
[
1555,
24,
810
]
],
[
[
310,
24,
1060
],
[
1060,
63,
810
]
],
[
[
310,
24,
350
],
[
350,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Enf... |
DB00281 | DB08912 | 608 | 1,040 | [
"DDInter1066",
"DDInter462"
] | Lidocaine | Dabrafenib | Ever since its discovery and availability for sale and use in the late 1940s, lidocaine has become an exceptionally commonly used medication. In particular, lidocaine's principal mode of action in acting as a local anesthetic that numbs the sensations of tissues means the agent is indicated for facilitating local anest... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Minor | 0 | [
[
[
608,
23,
1040
]
],
[
[
608,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
608,
18,
15501
],
[
15501,
57,
1040
]
],
[
[
608,
21,
28658
],
[
2865... | [
[
[
"Lidocaine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dabrafenib"
]
],
[
[
"Lidocaine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Lidocaine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Lidocaine (Compound) downregulates CCDC86 (Gene) and CCDC86 (Gene) is downregulated by Dabrafenib (Compound)
Lidocaine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Dabrafenib (Compound)
Lidocai... |
DB00501 | DB04908 | 752 | 1,671 | [
"DDInter380",
"DDInter741"
] | Cimetidine | Flibanserin | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder... | Moderate | 1 | [
[
[
752,
24,
1671
]
],
[
[
752,
23,
1135
],
[
1135,
62,
1671
]
],
[
[
752,
24,
1478
],
[
1478,
63,
1671
]
],
[
[
752,
24,
506
],
[
506,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flibanserin"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Naloxegol"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Flibanserin
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor ma... |
DB08865 | DB09083 | 1,593 | 880 | [
"DDInter448",
"DDInter996"
] | Crizotinib | Ivabradine | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Ivabradine is a novel heart rate lowering medicine for the symptomatic management of stable angina pectoralis and symptomatic chronic heart failure. Ivabradine, brand name Corlanor, was approved by the FDA in April 2015 for the treatment of chronic heart failure in patients with an ejection fraction of ≤35%, in sinus r... | Major | 2 | [
[
[
1593,
25,
880
]
],
[
[
1593,
63,
480
],
[
480,
24,
880
]
],
[
[
1593,
64,
1478
],
[
1478,
24,
880
]
],
[
[
1593,
24,
159
],
[
159,
... | [
[
[
"Crizotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivabradine"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
[
"Formoterol... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Ivabradine
Crizotinib may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a ... |
DB01211 | DB12147 | 609 | 241 | [
"DDInter393",
"DDInter661"
] | Clarithromycin | Erdafitinib | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Major | 2 | [
[
[
609,
25,
241
]
],
[
[
609,
24,
170
],
[
170,
24,
241
]
],
[
[
609,
25,
1456
],
[
1456,
24,
241
]
],
[
[
609,
25,
982
],
[
982,
6... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Erdafitinib"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
"... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Clarithromycin may lead to a major life threatening interaction when taken with Venetoclax and Venetoclax... |
DB01599 | DB13074 | 1,232 | 877 | [
"DDInter1523",
"DDInter1110"
] | Probucol | Macimorelin | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1232,
25,
877
]
],
[
[
1232,
62,
112
],
[
112,
23,
877
]
],
[
[
1232,
24,
913
],
[
913,
24,
877
]
],
[
[
1232,
63,
770
],
[
770,
... | [
[
[
"Probucol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Probucol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Probucol may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Probucol may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide and Apalut... |
DB09036 | DB10276 | 812 | 1,624 | [
"DDInter1668",
"DDInter1623"
] | Siltuximab | Rotavirus vaccine | Siltuximab is a chimeric (human-mouse) monoclonal immunoglobulin G1-kappa antibody produced in a Chinese hamster ovary (CHO) cell line by recombinant DNA technology. Siltuximab prevents the binding of IL-6 to soluble and membrane-bound IL-6 receptors by forming high affinity complexes with human interleukin-6 (IL-6). I... | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
812,
25,
1624
]
],
[
[
812,
64,
375
],
[
375,
25,
1624
]
],
[
[
812,
63,
58
],
[
58,
25,
1624
]
],
[
[
812,
24,
270
],
[
270,
64... | [
[
[
"Siltuximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Siltuximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Certolizumab pegol"
],
[
"Certolizum... | Siltuximab may lead to a major life threatening interaction when taken with Certolizumab pegol and Certolizumab pegol may lead to a major life threatening interaction when taken with Rotavirus vaccine
Siltuximab may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may ... |
DB01021 | DB11110 | 674 | 603 | [
"DDInter1861",
"DDInter1115"
] | Trichlormethiazide | Magnesium citrate | A thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830) | Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used. Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the ... | Moderate | 1 | [
[
[
674,
24,
603
]
],
[
[
674,
25,
57
],
[
57,
24,
603
]
],
[
[
674,
63,
870
],
[
870,
24,
603
]
],
[
[
674,
40,
1326
],
[
1326,
24,... | [
[
[
"Trichlormethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium citrate"
]
],
[
[
"Trichlormethiazide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
... | Trichlormethiazide may lead to a major life threatening interaction when taken with Arsenic trioxide and Arsenic trioxide may cause a moderate interaction that could exacerbate diseases when taken with Magnesium citrate
Trichlormethiazide may cause a moderate interaction that could exacerbate diseases when taken with F... |
DB00056 | DB01030 | 816 | 869 | [
"DDInter814",
"DDInter1835"
] | Gemtuzumab ozogamicin | Topotecan | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Moderate | 1 | [
[
[
816,
24,
869
]
],
[
[
816,
23,
872
],
[
872,
62,
869
]
],
[
[
816,
23,
1467
],
[
1467,
23,
869
]
],
[
[
816,
24,
1270
],
[
1270,
... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Topotecan"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemiflox... | Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin may cause a minor interaction that can limit clinical effects when taken with Topotecan
Gemtuzumab ozogamicin may cause a minor interaction that can limit clinical effects when taken with En... |
DB01156 | DB01577 | 593 | 1,529 | [
"DDInter252",
"DDInter1161"
] | Bupropion | Metamfetamine | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Major | 2 | [
[
[
593,
25,
1529
]
],
[
[
593,
64,
939
],
[
939,
40,
1529
]
],
[
[
593,
25,
93
],
[
93,
1,
1529
]
],
[
[
593,
25,
22
],
[
22,
24,
... | [
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metamfetamine"
]
],
[
[
"Bupropion",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Benzphetamine"
],
[
"Benzphetamine",
... | Bupropion may lead to a major life threatening interaction when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Bupropion may lead to a major life threatening interaction when taken with Dextroamphetamine and Dextroamphetamine (Compound) resembles Metamfetamine (Compound)
Buprop... |
DB00405 | DB11601 | 128 | 1,270 | [
"DDInter517",
"DDInter1889"
] | Dexbrompheniramine | Tuberculin purified protein derivative | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
128,
24,
1270
]
],
[
[
128,
24,
13
],
[
13,
24,
1270
]
],
[
[
128,
63,
1242
],
[
1242,
24,
1270
]
],
[
[
128,
24,
13
],
[
13,
63... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken w... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Dexbrompheniramine may cause a moderate interaction that could exace... |
DB00015 | DB00749 | 582 | 59 | [
"DDInter1585",
"DDInter699"
] | Reteplase | Etodolac | Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids p... | Etodolac is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic properties. Its therapeutic effects are due to its ability to inhibit prostaglandin synthesis. It is indicated for relief of signs and symptoms of rheumatoid arthritis and osteoarthritis. | Moderate | 1 | [
[
[
582,
24,
59
]
],
[
[
582,
24,
1018
],
[
1018,
24,
59
]
],
[
[
582,
24,
1039
],
[
1039,
63,
59
]
],
[
[
582,
64,
1578
],
[
1578,
... | [
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etodolac"
]
],
[
[
"Reteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticlopidine"
],
[
... | Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Ticlopidine and Ticlopidine may cause a moderate interaction that could exacerbate diseases when taken with Etodolac
Reteplase may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dex... |
DB01045 | DB12500 | 463 | 283 | [
"DDInter1590",
"DDInter714"
] | Rifampicin | Fedratinib | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Major | 2 | [
[
[
463,
25,
283
]
],
[
[
463,
25,
466
],
[
466,
62,
283
]
],
[
[
463,
25,
351
],
[
351,
23,
283
]
],
[
[
463,
64,
1419
],
[
1419,
2... | [
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fedratinib"
]
],
[
[
"Rifampicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Darolutamide"
],
[
"Darolutamide",
"{... | Rifampicin may lead to a major life threatening interaction when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Rifampicin may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor inter... |
DB00443 | DB10795 | 251 | 221 | [
"DDInter195",
"DDInter1486"
] | Betamethasone | Poliovirus type 1 antigen (formaldehyde inactivated) | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
251,
24,
221
]
],
[
[
251,
64,
581
],
[
581,
24,
221
]
],
[
[
251,
63,
599
],
[
599,
24,
221
]
],
[
[
251,
1,
1486
],
[
1486,
24... | [
[
[
"Betamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Betamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Betamethasone may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Betamethasone may cause a moderate interaction that could exacerbate diseases when... |
DB01110 | DB09389 | 86 | 517 | [
"DDInter1209",
"DDInter1315"
] | Miconazole | Norgestrel | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Norgestrel is synthetic steroidal progestin that is used in combination with ethinyl estradiol for oral contraception. Norgestrel is composed of a racemic mixture of two stereoisomers, dextronorgestrel and levonorgestrel. However, only the levorotary enantiomer ([levonorgestrel]) is biologically active. | Moderate | 1 | [
[
[
86,
24,
517
]
],
[
[
86,
24,
159
],
[
159,
63,
517
]
],
[
[
86,
24,
129
],
[
129,
24,
517
]
],
[
[
86,
63,
600
],
[
600,
24,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norgestrel"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Larotrectinib"
],
[... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Norgestrel
Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide an... |
DB00312 | DB00341 | 1,023 | 1,242 | [
"DDInter1423",
"DDInter343"
] | Pentobarbital | Cetirizine | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
1023,
24,
1242
]
],
[
[
1023,
24,
537
],
[
537,
63,
1242
]
],
[
[
1023,
21,
29027
],
[
29027,
60,
1242
]
],
[
[
1023,
63,
1031
],
[
10... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Pentobarbital (Compound) causes Ataxia (Side Effect) and Ataxia (Side Effect) is caused by Cetirizine (Compound... |
DB01097 | DB01157 | 1,377 | 304 | [
"DDInter1033",
"DDInter1875"
] | Leflunomide | Trimetrexate | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Major | 2 | [
[
[
1377,
25,
304
]
],
[
[
1377,
21,
28703
],
[
28703,
60,
304
]
],
[
[
1377,
64,
600
],
[
600,
23,
304
]
],
[
[
1377,
64,
58
],
[
58,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Trimetrexate"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused by {v} (Co... | Leflunomide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Trimetrexate (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a minor interaction that can limit clinical effects when taken with Trimetrexate
Lefluno... |
DB00675 | DB09075 | 888 | 498 | [
"DDInter1744",
"DDInter621"
] | Tamoxifen | Edoxaban | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Major | 2 | [
[
[
888,
25,
498
]
],
[
[
888,
64,
109
],
[
109,
24,
498
]
],
[
[
888,
24,
1237
],
[
1237,
24,
498
]
],
[
[
888,
24,
1017
],
[
1017,
... | [
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Edoxaban"
]
],
[
[
"Tamoxifen",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Duloxetine"
],
[
"Duloxetine",
"{u} may c... | Tamoxifen may lead to a major life threatening interaction when taken with Duloxetine and Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Edoxaban
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Clomipramine and Clomipramine may cause ... |
DB00307 | DB00776 | 1,101 | 1,335 | [
"DDInter202",
"DDInter1360"
] | Bexarotene | Oxcarbazepine | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Minor | 0 | [
[
[
1101,
23,
1335
]
],
[
[
1101,
23,
1236
],
[
1236,
1,
1335
]
],
[
[
1101,
24,
307
],
[
307,
1,
1335
]
],
[
[
1101,
6,
8374
],
[
8374,
... | [
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Bexarotene",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Carbamazepine"
],
[
... | Bexarotene may cause a minor interaction that can limit clinical effects when taken with Carbamazepine and Carbamazepine (Compound) resembles Oxcarbazepine (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil (Compound) resembles Oxcarbazepine (Co... |
DB00023 | DB00519 | 305 | 1,638 | [
"DDInter127",
"DDInter1843"
] | Asparaginase Escherichia coli | Trandolapril | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
305,
24,
1638
]
],
[
[
305,
24,
954
],
[
954,
40,
1638
]
],
[
[
305,
24,
170
],
[
170,
63,
1638
]
],
[
[
305,
24,
590
],
[
590,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may... |
DB00690 | DB09065 | 1,216 | 760 | [
"DDInter762",
"DDInter424"
] | Flurazepam | Cobicistat | A benzodiazepine derivative used mainly as a hypnotic. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1216,
24,
760
]
],
[
[
1216,
40,
523
],
[
523,
24,
760
]
],
[
[
1216,
24,
609
],
[
609,
24,
760
]
],
[
[
1216,
63,
1419
],
[
1419,
... | [
[
[
"Flurazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Flurazepam",
"{u} (Compound) resembles {v} (Compound)",
"Alprazolam"
],
[
"Alprazolam",
"{u} may cause a moderat... | Flurazepam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat
Flurazepam may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction th... |
DB01218 | DB11901 | 1,493 | 913 | [
"DDInter852",
"DDInter107"
] | Halofantrine | Apalutamide | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
1493,
25,
913
]
],
[
[
1493,
62,
112
],
[
112,
23,
913
]
],
[
[
1493,
64,
600
],
[
600,
24,
913
]
],
[
[
1493,
24,
28
],
[
28,
2... | [
[
[
"Halofantrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Halofantrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Halofantrine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Halofantrine may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole m... |
DB06209 | DB06822 | 256 | 802 | [
"DDInter1508",
"DDInter1812"
] | Prasugrel | Tinzaparin | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Tinzaparin is a low molecular weight heparin (LMWH), produced by enzymatic depolymerization of unfractionated heparin from porcine intestinal mucosa. It is a heterogeneous mixture of with an average molecular weight between 5500 and 7500 daltons. Tinzaparin is composed of molecules with and without a special site for h... | Major | 2 | [
[
[
256,
25,
802
]
],
[
[
256,
23,
944
],
[
944,
62,
802
]
],
[
[
256,
63,
222
],
[
222,
24,
802
]
],
[
[
256,
24,
1427
],
[
1427,
6... | [
[
[
"Prasugrel",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tinzaparin"
]
],
[
[
"Prasugrel",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
"Chamomile",
... | Prasugrel may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Tinzaparin
Prasugrel may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine m... |
DB00213 | DB00705 | 837 | 441 | [
"DDInter1388",
"DDInter496"
] | Pantoprazole | Delavirdine | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Moderate | 1 | [
[
[
837,
24,
441
]
],
[
[
837,
6,
10215
],
[
10215,
45,
441
]
],
[
[
837,
21,
28709
],
[
28709,
60,
441
]
],
[
[
837,
1,
379
],
[
379,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Delavirdine"
]
],
[
[
"Pantoprazole",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Comp... | Pantoprazole (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Delavirdine (Compound)
Pantoprazole (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Delavirdine (Compound)
Pantoprazole (Compound) resembles Rabeprazole (Compound) and Rabeprazole may cause a... |
DB00342 | DB00468 | 1,181 | 1,424 | [
"DDInter1770",
"DDInter1557"
] | Terfenadine | Quinine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | An alkaloid derived from the bark of the cinchona tree. It is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It... | Major | 2 | [
[
[
1181,
25,
1424
]
],
[
[
1181,
24,
307
],
[
307,
62,
1424
]
],
[
[
1181,
23,
1247
],
[
1247,
62,
1424
]
],
[
[
1181,
64,
529
],
[
529,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Modafinil"
],
[
"Modafinil",
... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modafinil may cause a minor interaction that can limit clinical effects when taken with Quinine
Terfenadine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfame... |
DB11691 | DB12035 | 1,499 | 943 | [
"DDInter1258",
"DDInter1641"
] | Naldemedine | Sarecycline | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1499,
24,
943
]
],
[
[
1499,
63,
1135
],
[
1135,
23,
943
]
],
[
[
1499,
63,
1456
],
[
1456,
24,
943
]
],
[
[
1499,
24,
1619
],
[
1619,... | [
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Naldemedine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],
[
... | Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Sarecycline
Naldemedine may cause a moderate interaction that could exacerbate diseases when taken with Venetoclax and Venetoc... |
DB00215 | DB00397 | 1,230 | 1,466 | [
"DDInter388",
"DDInter1458"
] | Citalopram | Phenylpropanolamine | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Major | 2 | [
[
[
1230,
25,
1466
]
],
[
[
1230,
64,
73
],
[
73,
25,
1466
]
],
[
[
1230,
6,
7390
],
[
7390,
45,
1466
]
],
[
[
1230,
21,
29027
],
[
29027,... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenylpropanolamine"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phentermine"
],
[
"Phentermine",
... | Citalopram may lead to a major life threatening interaction when taken with Phentermine and Phentermine may lead to a major life threatening interaction when taken with Phenylpropanolamine
Citalopram (Compound) binds SLC6A2 (Gene) and SLC6A2 (Gene) is bound by Phenylpropanolamine (Compound)
Citalopram (Compound) causes... |
DB00331 | DB11255 | 1,645 | 1,371 | [
"DDInter1164",
"DDInter374"
] | Metformin | Chromium picolinate | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Chromium picolinate has a chemical formula CrPic3 and reddish-pink color. It is a coordination complex consisting of chromium(III) and picolinic acid. Chromium picolinate is used as a nutritional supplement for optimal insulin function in patients with Type 2 diabetes or promotion of weight loss. Chromium ions are show... | Moderate | 1 | [
[
[
1645,
24,
1371
]
],
[
[
1645,
63,
245
],
[
245,
24,
1371
]
],
[
[
1645,
24,
473
],
[
473,
24,
1371
]
],
[
[
1645,
62,
1647
],
[
1647,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chromium picolinate"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Chromium picolinate
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide ... |
DB00927 | DB00978 | 1,559 | 739 | [
"DDInter712",
"DDInter1084"
] | Famotidine | Lomefloxacin | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Moderate | 1 | [
[
[
1559,
24,
739
]
],
[
[
1559,
24,
945
],
[
945,
40,
739
]
],
[
[
1559,
63,
1176
],
[
1176,
1,
739
]
],
[
[
1559,
62,
1467
],
[
1467,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sparfloxacin"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin... |
DB06448 | DB09074 | 171 | 1,362 | [
"DDInter1087",
"DDInter1327"
] | Lonafarnib | Olaparib | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
171,
25,
1362
]
],
[
[
171,
63,
896
],
[
896,
24,
1362
]
],
[
[
171,
25,
1478
],
[
1478,
24,
1362
]
],
[
[
171,
64,
467
],
[
467,
... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Etoposide",
... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Lonafarnib may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a mode... |
DB00717 | DB14724 | 1,197 | 48 | [
"DDInter1312",
"DDInter634"
] | Norethisterone | Emapalumab | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Emapalumab, also known as NI-0501, is a fully human monoclonal antibody that targets interferon gamma. Emapalumab development was sponsored by NovImmune SA, further developed by Sobi and FDA approved on November 20, 2018.[A38676, L4840] The approval of emapalumab was followed by the designation of orphan drug, priority... | Moderate | 1 | [
[
[
1197,
24,
48
]
],
[
[
1197,
40,
890
],
[
890,
24,
48
]
],
[
[
1197,
1,
1336
],
[
1336,
24,
48
]
],
[
[
1197,
63,
1031
],
[
1031,
... | [
[
[
"Norethisterone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Emapalumab"
]
],
[
[
"Norethisterone",
"{u} (Compound) resembles {v} (Compound)",
"Mestranol"
],
[
"Mestranol",
"{u} may cause a m... | Norethisterone (Compound) resembles Mestranol (Compound) and Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Emapalumab
Norethisterone (Compound) resembles Etonogestrel (Compound) and Etonogestrel may cause a moderate interaction that could exacerbate diseases when taken with E... |
DB04845 | DB08873 | 309 | 74 | [
"DDInter1001",
"DDInter221"
] | Ixabepilone | Boceprevir | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Moderate | 1 | [
[
[
309,
24,
74
]
],
[
[
309,
6,
8374
],
[
8374,
45,
74
]
],
[
[
309,
21,
28821
],
[
28821,
60,
74
]
],
[
[
309,
24,
310
],
[
310,
2... | [
[
[
"Ixabepilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Boceprevir"
]
],
[
[
"Ixabepilone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Ixabepilone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Boceprevir (Compound)
Ixabepilone (Compound) causes Sepsis (Side Effect) and Sepsis (Side Effect) is caused by Boceprevir (Compound)
Ixabepilone may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazi... |
DB06595 | DB09082 | 1,491 | 659 | [
"DDInter1214",
"DDInter1934"
] | Midostaurin | Vilanterol | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
1491,
24,
659
]
],
[
[
1491,
63,
1220
],
[
1220,
23,
659
]
],
[
[
1491,
63,
1570
],
[
1570,
24,
659
]
],
[
[
1491,
24,
1296
],
[
1296,... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Azithromycin an... |
DB01177 | DB10583 | 77 | 949 | [
"DDInter904",
"DDInter415"
] | Idarubicin | Clostridium tetani toxoid antigen (formaldehyde inactivated) | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
77,
24,
949
]
],
[
[
77,
64,
550
],
[
550,
24,
949
]
],
[
[
77,
63,
589
],
[
589,
24,
949
]
],
[
[
77,
25,
1259
],
[
1259,
63,
... | [
[
[
"Idarubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Idarubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",... | Idarubicin may lead to a major life threatening interaction when taken with Trastuzumab and Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Idarubicin may cause a moderate interaction that could exacerbate diseases ... |
DB00191 | DB01309 | 73 | 1,254 | [
"DDInter1447",
"DDInter933"
] | Phentermine | Insulin glulisine | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
73,
24,
1254
]
],
[
[
73,
35,
280
],
[
280,
63,
1254
]
],
[
[
73,
24,
1645
],
[
1645,
24,
1254
]
],
[
[
73,
36,
1529
],
[
1529,
... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Phentermine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases whe... | Phentermine (Compound) resembles Mephentermine (Compound) and Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Mephentermine and Me
Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Metformin and Metformin may cause a moderate interact... |
DB00196 | DB09054 | 600 | 384 | [
"DDInter743",
"DDInter905"
] | Fluconazole | Idelalisib | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
600,
24,
384
]
],
[
[
600,
23,
222
],
[
222,
23,
384
]
],
[
[
600,
25,
318
],
[
318,
23,
384
]
],
[
[
600,
23,
1627
],
[
1627,
6... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sibutramine"
],
[
... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Fluconazole may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may ca... |
DB01242 | DB01246 | 1,237 | 820 | [
"DDInter410",
"DDInter45"
] | Clomipramine | Alimemazine | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1237,
24,
820
]
],
[
[
1237,
63,
104
],
[
104,
40,
820
]
],
[
[
1237,
1,
11275
],
[
11275,
40,
820
]
],
[
[
1237,
63,
401
],
[
401,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Clomipramine (Compound) resembles Chlorprothixene (Compound) and Chlorprothixene (Compound) resembles Alimemazine (Compound)
Clomipramine may cause a mod... |
DB00069 | DB00609 | 367 | 595 | [
"DDInter946",
"DDInter694"
] | Interferon alfacon-1 | Ethionamide | Interferon alfacon-1 is a recombinant non-naturally occurring type-I interferon. The 166-amino acid sequence of Interferon alfacon-1 was derived by scanning the sequences of several natural interferon alpha subtypes and assigning the most frequently observed amino acid in each corresponding position. Four additional am... | A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868) | Moderate | 1 | [
[
[
367,
24,
595
]
],
[
[
367,
24,
372
],
[
372,
63,
595
]
],
[
[
367,
63,
1057
],
[
1057,
24,
595
]
],
[
[
367,
24,
597
],
[
597,
2... | [
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ethionamide"
]
],
[
[
"Interferon alfacon-1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofar... | Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken with Clofarabine and Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Ethionamide
Interferon alfacon-1 may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00554 | DB01082 | 1,027 | 1,448 | [
"DDInter1478",
"DDInter1713"
] | Piroxicam | Streptomycin | A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
1027,
24,
1448
]
],
[
[
1027,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
1027,
24,
1272
],
[
1272,
63,
1448
]
],
[
[
1027,
63,
91
],
[
91,... | [
[
[
"Piroxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Piroxicam",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compound)... | Piroxicam (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Piroxicam may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine and Flucytosine may cause a moderate interaction that could exacerbate diseases when taken with Streptomycin
Piroxicam ma... |
DB00373 | DB08881 | 461 | 868 | [
"DDInter1809",
"DDInter1925"
] | Timolol | Vemurafenib | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
461,
24,
868
]
],
[
[
461,
6,
12523
],
[
12523,
45,
868
]
],
[
[
461,
7,
6952
],
[
6952,
46,
868
]
],
[
[
461,
21,
28847
],
[
28847,
... | [
[
[
"Timolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Timolol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
... | Timolol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Vemurafenib (Compound)
Timolol (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Vemurafenib (Compound)
Timolol (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Vemurafenib (Compound)
Timo... |
DB00250 | DB00526 | 10 | 1,555 | [
"DDInter475",
"DDInter1355"
] | Dapsone | Oxaliplatin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
10,
24,
1555
]
],
[
[
10,
6,
9375
],
[
9375,
45,
1555
]
],
[
[
10,
1,
1247
],
[
1247,
62,
1555
]
],
[
[
10,
24,
289
],
[
289,
24... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Dapsone",
"{u} (Compound) binds {v} (Gene)",
"MPO"
],
[
"MPO",
"{u} (Gene) is bound by {v} (Compound)",
"Oxa... | Dapsone (Compound) binds MPO (Gene) and MPO (Gene) is bound by Oxaliplatin (Compound)
Dapsone (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Oxaliplatin
Dapsone may cause a moderate interaction that could exacerbate dis... |
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