drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00831 | DB04837 | 1,178 | 649 | [
"DDInter1866",
"DDInter407"
] | Trifluoperazine | Clofedanol | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1178,
24,
649
]
],
[
[
1178,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1178,
63,
832
],
[
832,
40,
649
]
],
[
[
1178,
63,
701
],
[
701,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB00307 | DB11932 | 1,101 | 327 | [
"DDInter202",
"DDInter3"
] | Bexarotene | Abametapir (topical) | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Abametapir is a member of bipyridines. | Moderate | 1 | [
[
[
1101,
24,
327
]
],
[
[
1101,
24,
124
],
[
124,
63,
327
]
],
[
[
1101,
62,
168
],
[
168,
24,
327
]
],
[
[
1101,
24,
613
],
[
613,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abametapir"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Abametapir
Bexarotene m... |
DB00999 | DB11093 | 504 | 636 | [
"DDInter883",
"DDInter273"
] | Hydrochlorothiazide | Calcium citrate | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
504,
24,
636
]
],
[
[
504,
62,
1572
],
[
1572,
24,
636
]
],
[
[
504,
1,
1014
],
[
1014,
24,
636
]
],
[
[
504,
23,
1669
],
[
1669,
... | [
[
[
"Hydrochlorothiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Hydrochlorothiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Demecl... | Hydrochlorothiazide may cause a minor interaction that can limit clinical effects when taken with Demeclocycline and Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Hydrochlorothiazide (Compound) resembles Benzthiazide (Compound) and Benzthiazide may cause ... |
DB00673 | DB00877 | 723 | 629 | [
"DDInter112",
"DDInter1678"
] | Aprepitant | Sirolimus | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Moderate | 1 | [
[
[
723,
24,
629
]
],
[
[
723,
6,
21998
],
[
21998,
45,
629
]
],
[
[
723,
21,
29203
],
[
29203,
60,
629
]
],
[
[
723,
23,
907
],
[
907,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A7-CYP3A51P"
],
[
"CYP3A7-CYP3A51P",
"{u} (Gene) is bound by... | Aprepitant (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Sirolimus (Compound)
Aprepitant (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Sirolimus (Compound)
Aprepitant may cause a minor interaction... |
DB00421 | DB06605 | 443 | 1,409 | [
"DDInter1707",
"DDInter108"
] | Spironolactone | Apixaban | Spironolactone is a potassium-sparing diuretic. It binds to mineralocorticoid receptors and functions as aldosterone antagonists. It promotes sodium and water excretion and potassium retention. Spironolactone was originally developed purely for this ability before other pharmacodynamic properties of the drug were disco... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
443,
24,
1409
]
],
[
[
443,
6,
3486
],
[
3486,
45,
1409
]
],
[
[
443,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
443,
24,
1374
],
[
1374,... | [
[
[
"Spironolactone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Spironolactone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compo... | Spironolactone (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Apixaban (Compound)
Spironolactone (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Spironolactone may cause a moderate interaction that could exacerbate diseases when taken with Abiratero... |
DB00284 | DB06663 | 1,647 | 1,154 | [
"DDInter11",
"DDInter1398"
] | Acarbose | Pasireotide | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Moderate | 1 | [
[
[
1647,
24,
1154
]
],
[
[
1647,
63,
966
],
[
966,
40,
1154
]
],
[
[
1647,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
1647,
24,
663
],
[
663... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pasireotide"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Octreotide"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Octreotide and Octreotide (Compound) resembles Pasireotide (Compound)
Acarbose (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Acarbose may cause a moderate intera... |
DB00397 | DB00731 | 1,466 | 1,144 | [
"DDInter1458",
"DDInter1269"
] | Phenylpropanolamine | Nateglinide | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Moderate | 1 | [
[
[
1466,
24,
1144
]
],
[
[
1466,
63,
80
],
[
80,
40,
1144
]
],
[
[
1466,
1,
11215
],
[
11215,
40,
1144
]
],
[
[
1466,
35,
93
],
[
93,
... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nateglinide"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphetam... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Amphetamine and Amphetamine (Compound) resembles Nateglinide (Compound)
Phenylpropanolamine (Compound) resembles L-Phenylalanine (Compound) and L-Phenylalanine (Compound) resembles Nateglinide (Compound)
Phenylpropanolam... |
DB00283 | DB00424 | 701 | 19 | [
"DDInter395",
"DDInter896"
] | Clemastine | Hyoscyamine | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Hyoscyamine is a tropane alkaloid and the levo-isomer of [atropine]. It is commonly extracted from plants in the _Solanaceae_ or nightshade family. Research into the action of hyoscyamine in published literature dates back to 1826. Hyoscyamine is used for a wide variety of treatments and therapeutics due to its antimus... | Moderate | 1 | [
[
[
701,
24,
19
]
],
[
[
701,
24,
85
],
[
85,
63,
19
]
],
[
[
701,
18,
4930
],
[
4930,
57,
19
]
],
[
[
701,
21,
29093
],
[
29093,
60... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]
],
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
],
[
... | Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine
Clemastine (Compound) downregulates DLD (Gene) and DLD (Gene) is downregulated by Hyoscyamine (Compound)
Clemastine... |
DB00781 | DB00795 | 1,481 | 50 | [
"DDInter1489",
"DDInter1725"
] | Polymyxin B | Sulfasalazine | Polymyxin B was discovered in the 1940s. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic[A176426,FDA Label]. All gram-positive bacteria, fungi, and the gram... | Sulfasalazine is an anti-inflammatory drug structurally related to salicylates and other non-steroidal anti-inflammatory drugs. It is indicated for managing inflammatory diseases such as ulcerative colitis and rheumatoid arthritis (RA).[L39065, A255582] Metabolized by intestinal bacteria, sulfasalazine is broken down i... | Moderate | 1 | [
[
[
1481,
24,
50
]
],
[
[
1481,
24,
712
],
[
712,
1,
50
]
],
[
[
1481,
24,
890
],
[
890,
63,
50
]
],
[
[
1481,
63,
91
],
[
91,
24,
... | [
[
[
"Polymyxin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazine"
]
],
[
[
"Polymyxin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olsalazine"
],
... | Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine (Compound) resembles Sulfasalazine (Compound)
Polymyxin B may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol may cause a moderate interaction that co... |
DB00342 | DB01236 | 1,181 | 679 | [
"DDInter1770",
"DDInter1664"
] | Terfenadine | Sevoflurane | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 199... | Moderate | 1 | [
[
[
1181,
24,
679
]
],
[
[
1181,
24,
1262
],
[
1262,
40,
679
]
],
[
[
1181,
23,
112
],
[
112,
23,
679
]
],
[
[
1181,
24,
484
],
[
484,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sevoflurane"
]
],
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perflutren"
],
[... | Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Perflutren and Perflutren (Compound) resembles Sevoflurane (Compound)
Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that c... |
DB00163 | DB06176 | 1,461 | 1,342 | [
"DDInter1943",
"DDInter1616"
] | Vitamin E | Romidepsin | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
1461,
24,
1342
]
],
[
[
1461,
24,
51
],
[
51,
24,
1342
]
],
[
[
1461,
62,
66
],
[
66,
24,
1342
]
],
[
[
1461,
23,
259
],
[
259,
... | [
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Vitamin E",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
[
... | Vitamin E may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Romidepsin
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Efalizumab and Efaliz... |
DB00738 | DB11986 | 485 | 484 | [
"DDInter1420",
"DDInter648"
] | Pentamidine | Entrectinib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
485,
24,
484
]
],
[
[
485,
23,
1247
],
[
1247,
23,
484
]
],
[
[
485,
24,
1539
],
[
1539,
24,
484
]
],
[
[
485,
63,
322
],
[
322,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin ... |
DB00275 | DB01222 | 217 | 617 | [
"DDInter1330",
"DDInter246"
] | Olmesartan | Budesonide | Olmesartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes [telmisartan], [candesartan], [losartan], [valsartan], and [irbesartan]. ARBs selectively bind to angiotensin receptor 1 (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, w... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
217,
24,
617
]
],
[
[
217,
24,
251
],
[
251,
1,
617
]
],
[
[
217,
21,
28719
],
[
28719,
60,
617
]
],
[
[
217,
24,
484
],
[
484,
... | [
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Olmesartan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
[... | Olmesartan may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Olmesartan (Compound) causes Pain (Side Effect) and Pain (Side Effect) is caused by Budesonide (Compound)
Olmesartan may cause a moderate interaction that... |
DB06589 | DB11901 | 1,250 | 913 | [
"DDInter1400",
"DDInter107"
] | Pazopanib | Apalutamide | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Moderate | 1 | [
[
[
1250,
24,
913
]
],
[
[
1250,
62,
112
],
[
112,
23,
913
]
],
[
[
1250,
24,
110
],
[
110,
62,
913
]
],
[
[
1250,
63,
1322
],
[
1322,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apalutamide"
]
],
[
[
"Pazopanib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Pazopanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Apalutamide
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Polatuzumab vedotin ... |
DB00252 | DB09122 | 362 | 1,613 | [
"DDInter1460",
"DDInter1409"
] | Phenytoin | Peginterferon beta-1a | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
362,
24,
1613
]
],
[
[
362,
64,
600
],
[
600,
24,
1613
]
],
[
[
362,
1,
651
],
[
651,
24,
1613
]
],
[
[
362,
24,
267
],
[
267,
2... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Phenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"... | Phenytoin may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Phenytoin (Compound) resembles Fosphenytoin (Compound) and Fos
Phenytoin may cause a moderate interaction that coul... |
DB00196 | DB09472 | 600 | 1,383 | [
"DDInter743",
"DDInter1693"
] | Fluconazole | Sodium sulfate | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
600,
24,
1383
]
],
[
[
600,
23,
609
],
[
609,
24,
1383
]
],
[
[
600,
63,
521
],
[
521,
24,
1383
]
],
[
[
600,
24,
1454
],
[
1454,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clarithromycin"
],
... | Fluconazole may cause a minor interaction that can limit clinical effects when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Goserelin... |
DB00404 | DB00902 | 523 | 104 | [
"DDInter54",
"DDInter1168"
] | Alprazolam | Methdilazine | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
523,
24,
104
]
],
[
[
523,
24,
13
],
[
13,
24,
104
]
],
[
[
523,
24,
820
],
[
820,
1,
104
]
],
[
[
523,
1,
11332
],
[
11332,
40,... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine... |
DB11248 | DB15091 | 1,193 | 676 | [
"DDInter1965",
"DDInter1901"
] | Zinc gluconate | Upadacitinib | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wit... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Minor | 0 | [
[
[
1193,
23,
676
]
],
[
[
1193,
62,
1184
],
[
1184,
25,
676
]
],
[
[
1193,
23,
76
],
[
76,
25,
676
]
],
[
[
1193,
23,
725
],
[
725,
... | [
[
[
"Zinc gluconate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Upadacitinib"
]
],
[
[
"Zinc gluconate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Anakinra"
],
... | Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Anakinra and Anakinra may lead to a major life threatening interaction when taken with Upadacitinib
Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Mogamulizumab and Mogamulizumab ma... |
DB00197 | DB04946 | 1,324 | 924 | [
"DDInter1881",
"DDInter907"
] | Troglitazone | Iloperidone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
1324,
24,
924
]
],
[
[
1324,
24,
883
],
[
883,
1,
924
]
],
[
[
1324,
24,
519
],
[
519,
40,
924
]
],
[
[
1324,
24,
741
],
[
741,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gefitinib"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Gefitinib and Gefitinib (Compound) resembles Iloperidone (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperidone (Co... |
DB00491 | DB00951 | 127 | 1,072 | [
"DDInter1217",
"DDInter986"
] | Miglitol | Isoniazid | Miglitol inhibits the breakdown complex carbohydrates into glucose. It is primarily used in diabetes mellitus type 2 for establishing greater glycemic control by preventing the digestion of carbohydrates (such as disaccharides, oligosaccharides, and polysaccharides) into monosaccharides which can be absorbed by the bod... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
127,
24,
1072
]
],
[
[
127,
21,
28722
],
[
28722,
60,
1072
]
],
[
[
127,
24,
1486
],
[
1486,
62,
1072
]
],
[
[
127,
24,
870
],
[
870,
... | [
[
[
"Miglitol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Miglitol",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {v} (... | Miglitol (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Isoniazid (Compound)
Miglitol may cause a moderate interaction that could exacerbate diseases when taken with Methylprednisolone and Methylprednisolone may cause a minor interaction that can limit clinical effects when taken with Ison... |
DB00877 | DB01039 | 629 | 535 | [
"DDInter1678",
"DDInter718"
] | Sirolimus | Fenofibrate | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Fenofibrate is a fibric acid derivative like [clofibrate] and [gemfibrozil]. Fenofibrate is used to treat primary hypercholesterolemia, mixed dyslipidemia, severe hypertriglyceridemia.[L8588,L8591] Fenofibrate was granted FDA approval on 31 December 1993. | Moderate | 1 | [
[
[
629,
24,
535
]
],
[
[
629,
64,
831
],
[
831,
1,
535
]
],
[
[
629,
63,
429
],
[
429,
1,
535
]
],
[
[
629,
6,
8374
],
[
8374,
45,
... | [
[
[
"Sirolimus",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenofibrate"
]
],
[
[
"Sirolimus",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Indomethacin"
],
[
"Indometha... | Sirolimus may lead to a major life threatening interaction when taken with Indomethacin and Indomethacin (Compound) resembles Fenofibrate (Compound)
Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Clofibrate and Clofibrate (Compound) resembles Fenofibrate (Compound)
Sirolimus (... |
DB04865 | DB12364 | 4 | 1,421 | [
"DDInter1335",
"DDInter200"
] | Omacetaxine mepesuccinate | Betrixaban | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Major | 2 | [
[
[
4,
25,
1421
]
],
[
[
4,
24,
637
],
[
637,
24,
1421
]
],
[
[
4,
63,
305
],
[
305,
24,
1421
]
],
[
[
4,
25,
927
],
[
927,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betrixaban"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi and Asparaginase Erwinia chrysanthemi may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Omacetaxine mepesuccinate may cause a moderate inte... |
DB00019 | DB00526 | 1,257 | 1,555 | [
"DDInter1405",
"DDInter1355"
] | Pegfilgrastim | Oxaliplatin | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Moderate | 1 | [
[
[
1257,
24,
1555
]
],
[
[
1257,
24,
141
],
[
141,
24,
1555
]
],
[
[
1257,
24,
1213
],
[
1213,
63,
1555
]
],
[
[
1257,
63,
1451
],
[
1451... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Floxuridine"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Floxuridine and Floxuridine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib an... |
DB01068 | DB09481 | 1,565 | 460 | [
"DDInter411",
"DDInter1113"
] | Clonazepam | Magnesium carbonate | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
1565,
23,
460
]
],
[
[
1565,
24,
401
],
[
401,
23,
460
]
],
[
[
1565,
40,
1382
],
[
1382,
23,
460
]
],
[
[
1565,
63,
999
],
[
999,
... | [
[
[
"Clonazepam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Clonazepam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Clonazepam may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Clonazepam (Compound) resembles Midazolam (Compound) and Midazolam may cause a minor interaction that... |
DB01149 | DB11691 | 851 | 1,499 | [
"DDInter1274",
"DDInter1258"
] | Nefazodone | Naldemedine | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Moderate | 1 | [
[
[
851,
24,
1499
]
],
[
[
851,
63,
723
],
[
723,
24,
1499
]
],
[
[
851,
25,
1670
],
[
1670,
24,
1499
]
],
[
[
851,
25,
1406
],
[
1406,
... | [
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naldemedine"
]
],
[
[
"Nefazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Naldemedine
Nefazodone may lead to a major life threatening interaction when taken with Eliglustat and Eliglustat may cause... |
DB00046 | DB01261 | 1,179 | 170 | [
"DDInter940",
"DDInter1679"
] | Insulin lispro | Sitagliptin | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Moderate | 1 | [
[
[
1179,
24,
170
]
],
[
[
1179,
23,
1103
],
[
1103,
23,
170
]
],
[
[
1179,
24,
52
],
[
52,
62,
170
]
],
[
[
1179,
24,
623
],
[
623,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
]
],
[
[
"Insulin lispro",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Insulin lispro may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Sitagliptin
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Dulaglutide and ... |
DB00679 | DB09330 | 684 | 985 | [
"DDInter1796",
"DDInter1352"
] | Thioridazine | Osimertinib | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
684,
25,
985
]
],
[
[
684,
23,
112
],
[
112,
23,
985
]
],
[
[
684,
24,
480
],
[
480,
24,
985
]
],
[
[
684,
24,
657
],
[
657,
63,... | [
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Thioridazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Thioridazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and... |
DB00526 | DB08880 | 1,555 | 1,510 | [
"DDInter1355",
"DDInter1771"
] | Oxaliplatin | Teriflunomide | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
1555,
25,
1510
]
],
[
[
1555,
63,
1461
],
[
1461,
23,
1510
]
],
[
[
1555,
24,
129
],
[
129,
63,
1510
]
],
[
[
1555,
24,
1136
],
[
1136... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitami... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Teriflunomide
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enz... |
DB00349 | DB11834 | 902 | 1,303 | [
"DDInter401",
"DDInter849"
] | Clobazam | Guselkumab | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
902,
24,
1303
]
],
[
[
902,
63,
58
],
[
58,
24,
1303
]
],
[
[
902,
40,
523
],
[
523,
24,
1303
]
],
[
[
902,
24,
259
],
[
259,
24... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
],
[
"... | Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Clobazam (Compound) resembles Alprazolam (Compound) and Alprazolam may cause a moderate interaction that could exace... |
DB00095 | DB09570 | 66 | 1,480 | [
"DDInter623",
"DDInter1002"
] | Efalizumab | Ixazomib | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Moderate | 1 | [
[
[
66,
24,
1480
]
],
[
[
66,
24,
496
],
[
496,
63,
1480
]
],
[
[
66,
24,
453
],
[
453,
24,
1480
]
],
[
[
66,
63,
1184
],
[
1184,
24... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixazomib"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hepatitis A Vaccine"
],
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Linez... |
DB00559 | DB00682 | 152 | 126 | [
"DDInter223",
"DDInter1951"
] | Bosentan | Warfarin | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
152,
24,
126
]
],
[
[
152,
6,
6017
],
[
6017,
45,
126
]
],
[
[
152,
62,
168
],
[
168,
23,
126
]
],
[
[
152,
24,
663
],
[
663,
23... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Bosentan",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Bosentan (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Warfarin (Compound)
Bosentan may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Warfarin
Bosentan may cause a moderate ... |
DB00206 | DB01069 | 1,245 | 401 | [
"DDInter1582",
"DDInter1533"
] | Reserpine | Promethazine | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a rese... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
1245,
24,
401
]
],
[
[
1245,
24,
1264
],
[
1264,
63,
401
]
],
[
[
1245,
24,
104
],
[
104,
24,
401
]
],
[
[
1245,
6,
4973
],
[
4973,
... | [
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Reserpine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
],
[
... | Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Reserpine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazi... |
DB00694 | DB14568 | 51 | 982 | [
"DDInter485",
"DDInter1000"
] | Daunorubicin | Ivosidenib | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
51,
25,
982
]
],
[
[
51,
23,
112
],
[
112,
23,
982
]
],
[
[
51,
25,
976
],
[
976,
24,
982
]
],
[
[
51,
24,
700
],
[
700,
24,
... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Daunorubicin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Daunorubicin may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib ma... |
DB00427 | DB04946 | 1,233 | 924 | [
"DDInter1879",
"DDInter907"
] | Triprolidine | Iloperidone | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Moderate | 1 | [
[
[
1233,
24,
924
]
],
[
[
1233,
24,
1664
],
[
1664,
1,
924
]
],
[
[
1233,
24,
519
],
[
519,
40,
924
]
],
[
[
1233,
6,
10104
],
[
10104,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iloperidone"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Risperidone"
],
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidone (Compound) resembles Iloperidone (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Paliperidone and Paliperidone (Compound) resembles Iloperidone... |
DB00418 | DB00619 | 536 | 1,419 | [
"DDInter1650",
"DDInter909"
] | Secobarbital | Imatinib | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
536,
24,
1419
]
],
[
[
536,
6,
6017
],
[
6017,
45,
1419
]
],
[
[
536,
21,
28762
],
[
28762,
60,
1419
]
],
[
[
536,
24,
222
],
[
222,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Secobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Secobarbital (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Imatinib (Compound)
Secobarbital (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Imatinib (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sib... |
DB00559 | DB00762 | 152 | 613 | [
"DDInter223",
"DDInter973"
] | Bosentan | Irinotecan | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. It is a derivative of camptothecin that inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cel... | Moderate | 1 | [
[
[
152,
24,
613
]
],
[
[
152,
6,
8374
],
[
8374,
45,
613
]
],
[
[
152,
18,
5795
],
[
5795,
46,
613
]
],
[
[
152,
21,
28645
],
[
28645,
... | [
[
[
"Bosentan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Irinotecan"
]
],
[
[
"Bosentan",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Bosentan (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Irinotecan (Compound)
Bosentan (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is upregulated by Irinotecan (Compound)
Bosentan (Compound) causes Cough (Side Effect) and Cough (Side Effect) is caused by Irinotecan (Compound)
Bosentan may cause... |
DB01320 | DB11691 | 651 | 1,499 | [
"DDInter783",
"DDInter1258"
] | Fosphenytoin | Naldemedine | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Naldemedine is an opioid receptor antagonist [FDA Label]. It is a modified form of to which a side chain has been added to increase molecular weight and polar surface area resulting in restricted transport across the blood brain barrier. Naldemedine was approved in 2017 in both the US and Japan for the treatment of Opi... | Major | 2 | [
[
[
651,
25,
1499
]
],
[
[
651,
40,
307
],
[
307,
23,
1499
]
],
[
[
651,
63,
723
],
[
723,
24,
1499
]
],
[
[
651,
64,
1419
],
[
1419,
... | [
[
[
"Fosphenytoin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naldemedine"
]
],
[
[
"Fosphenytoin",
"{u} (Compound) resembles {v} (Compound)",
"Modafinil"
],
[
"Modafinil",
"{u} may cause a minor interaction t... | Fosphenytoin (Compound) resembles Modafinil (Compound) and Modafinil may cause a minor interaction that can limit clinical effects when taken with Naldemedine
Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a moderate interaction that coul... |
DB00514 | DB00662 | 506 | 717 | [
"DDInter527",
"DDInter1873"
] | Dextromethorphan | Trimethobenzamide | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Trimethobenzamide is a novel antiemetic which prevents nausea and vomiting in humans. Its actions are unclear but most likely involves the chemoreceptor trigger zone (CTZ). In dogs pretreated with trimethobenzamide HCl, the emetic response to apomorphine is inhibited, while little or no protection is afforded against e... | Moderate | 1 | [
[
[
506,
24,
717
]
],
[
[
506,
21,
28921
],
[
28921,
60,
717
]
],
[
[
506,
24,
1382
],
[
1382,
63,
717
]
],
[
[
506,
64,
109
],
[
109,
... | [
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimethobenzamide"
]
],
[
[
"Dextromethorphan",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (S... | Dextromethorphan (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Trimethobenzamide (Compound)
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam may cause a moderate interaction that could exacerbate diseases when t... |
DB01006 | DB04855 | 300 | 540 | [
"DDInter1040",
"DDInter602"
] | Letrozole | Dronedarone | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Moderate | 1 | [
[
[
300,
24,
540
]
],
[
[
300,
6,
8374
],
[
8374,
45,
540
]
],
[
[
300,
21,
28883
],
[
28883,
60,
540
]
],
[
[
300,
24,
187
],
[
187,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
]
],
[
[
"Letrozole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Letrozole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound)
Letrozole (Compound) causes Skin disorder (Side Effect) and Skin disorder (Side Effect) is caused by Dronedarone (Compound)
Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone ... |
DB00529 | DB12245 | 789 | 823 | [
"DDInter779",
"DDInter1863"
] | Foscarnet | Triclabendazole | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Moderate | 1 | [
[
[
789,
24,
823
]
],
[
[
789,
23,
112
],
[
112,
23,
823
]
],
[
[
789,
63,
1010
],
[
1010,
24,
823
]
],
[
[
789,
24,
28
],
[
28,
24,... | [
[
[
"Foscarnet",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triclabendazole"
]
],
[
[
"Foscarnet",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Foscarnet may cause a moderate interaction that could exacerbate diseases when taken with Mefloquine and M... |
DB00501 | DB00630 | 752 | 1,485 | [
"DDInter380",
"DDInter42"
] | Cimetidine | Alendronic acid | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111]. It functions by preventing resorption of bone[FDA Label]. | Minor | 0 | [
[
[
752,
23,
1485
]
],
[
[
752,
21,
28921
],
[
28921,
60,
1485
]
],
[
[
752,
23,
428
],
[
428,
63,
1485
]
],
[
[
752,
23,
1512
],
[
1512,
... | [
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Alendronic acid"
]
],
[
[
"Cimetidine",
"{u} (Compound) causes {v} (Side Effect)",
"Dizziness"
],
[
"Dizziness",
"{u} (Side Effect) is c... | Cimetidine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Alendronic acid (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Ferrous fumarate and Ferrous fumarate may cause a moderate interaction that could exacerbate diseases when tak... |
DB01224 | DB14568 | 623 | 982 | [
"DDInter1553",
"DDInter1000"
] | Quetiapine | Ivosidenib | Initially approved by the FDA in 1997, quetiapine is a second-generation atypical antipsychotic used in schizophrenia, major depression, and bipolar disorder. Quetiapine demonstrates a high level of therapeutic efficacy and low risk of adverse effects during long-term treatment. It is well-tolerated and a suitable opti... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
623,
25,
982
]
],
[
[
623,
62,
112
],
[
112,
23,
982
]
],
[
[
623,
64,
1101
],
[
1101,
23,
982
]
],
[
[
623,
63,
543
],
[
543,
2... | [
[
[
"Quetiapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Quetiapine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Quetiapine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Quetiapine may lead to a major life threatening interaction when taken with Bexarotene and Bexarotene may caus... |
DB00705 | DB01410 | 441 | 423 | [
"DDInter496",
"DDInter375"
] | Delavirdine | Ciclesonide | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Moderate | 1 | [
[
[
441,
24,
423
]
],
[
[
441,
63,
1573
],
[
1573,
1,
423
]
],
[
[
441,
63,
1351
],
[
1351,
40,
423
]
],
[
[
441,
25,
1486
],
[
1486,
... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ciclesonide"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
[... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Ciclesonide (Compound)
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Flunisolide and Flunisolide (Compound) resembles Ciclesonide (Comp... |
DB00242 | DB01177 | 1,064 | 77 | [
"DDInter392",
"DDInter904"
] | Cladribine | Idarubicin | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Major | 2 | [
[
[
1064,
25,
77
]
],
[
[
1064,
5,
11555
],
[
11555,
44,
77
]
],
[
[
1064,
7,
1898
],
[
1898,
46,
77
]
],
[
[
1064,
18,
8358
],
[
8358,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idarubicin"
]
],
[
[
"Cladribine",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated b... | Cladribine (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Idarubicin (Compound)
Cladribine (Compound) upregulates GADD45A (Gene) and GADD45A (Gene) is upregulated by Idarubicin (Compound)
Cladribine (Compound) downregulates TSEN2 (Gene) and TSEN2 (Gene) is downregulated by... |
DB00373 | DB00945 | 461 | 1,479 | [
"DDInter1809",
"DDInter20"
] | Timolol | Acetylsalicylic acid | Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes. It is also used in tablet form as a drug to treat hypertension. Timolol was first approved by the FDA in 1978. This drug is marketed by several manufacturers and is an effective ag... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Minor | 0 | [
[
[
461,
23,
1479
]
],
[
[
461,
5,
11576
],
[
11576,
44,
1479
]
],
[
[
461,
6,
10215
],
[
10215,
45,
1479
]
],
[
[
461,
5,
11610
],
[
1161... | [
[
[
"Timolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Timolol",
"{u} (Compound) treats {v} (Disease)",
"coronary artery disease"
],
[
"coronary artery disease",
... | Timolol (Compound) treats coronary artery disease (Disease) and coronary artery disease (Disease) is treated by Acetylsalicylic acid (Compound)
Timolol (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Acetylsalicylic acid (Compound)
Timolol (Compound) treats migraine (Disease) and migraine (Disease) is pa... |
DB05239 | DB11901 | 866 | 913 | [
"DDInter425",
"DDInter107"
] | Cobimetinib | Apalutamide | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements . It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Res... | Major | 2 | [
[
[
866,
25,
913
]
],
[
[
866,
64,
600
],
[
600,
24,
913
]
],
[
[
866,
24,
1320
],
[
1320,
63,
913
]
],
[
[
866,
63,
495
],
[
495,
2... | [
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
]
],
[
[
"Cobimetinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fluconazole"
],
[
"Fluconazole",
"... | Cobimetinib may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Apalutamide
Cobimetinib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause... |
DB00294 | DB04868 | 1,336 | 478 | [
"DDInter701",
"DDInter1293"
] | Etonogestrel | Nilotinib | Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001. | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Moderate | 1 | [
[
[
1336,
24,
478
]
],
[
[
1336,
6,
8374
],
[
8374,
45,
478
]
],
[
[
1336,
21,
28963
],
[
28963,
60,
478
]
],
[
[
1336,
25,
1040
],
[
1040... | [
[
[
"Etonogestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
]
],
[
[
"Etonogestrel",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Etonogestrel (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Nilotinib (Compound)
Etonogestrel (Compound) causes Anxiety (Side Effect) and Anxiety (Side Effect) is caused by Nilotinib (Compound)
Etonogestrel may lead to a major life threatening interaction when taken with Dabrafenib and Dabrafenib may caus... |
DB00950 | DB08827 | 1,413 | 990 | [
"DDInter732",
"DDInter1085"
] | Fexofenadine | Lomitapide | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Moderate | 1 | [
[
[
1413,
35,
990
]
],
[
[
1413,
6,
4973
],
[
4973,
45,
990
]
],
[
[
1413,
21,
28658
],
[
28658,
60,
990
]
],
[
[
1413,
24,
1476
],
[
1476... | [
[
[
"Fexofenadine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomitapide"
]
],
[
[
"Fexofenadine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
... | Fexofenadine (Compound) resembles Lomitapide (Compound) and
Fexofenadine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Lomitapide (Compound)
Fexofenadine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Lomitapide (Compound)
Fexofenadine may cause a moderate interaction that... |
DB00467 | DB00635 | 1,467 | 1,573 | [
"DDInter644",
"DDInter1515"
] | Enoxacin | Prednisone | A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid. | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Major | 2 | [
[
[
1467,
25,
1573
]
],
[
[
1467,
25,
175
],
[
175,
40,
1573
]
],
[
[
1467,
64,
251
],
[
251,
1,
1573
]
],
[
[
1467,
25,
167
],
[
167,
... | [
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
]
],
[
[
"Enoxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone",
"{u}... | Enoxacin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Enoxacin may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone (Compound) resembles Prednisone (Compound)
Enoxacin may lead to a... |
DB00189 | DB01156 | 459 | 593 | [
"DDInter691",
"DDInter252"
] | Ethchlorvynol | Bupropion | Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. | Bupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective Disorder (SAD), and as an aid for smoking cessation. Bupropion exerts its pharmacological effects by weakly inh... | Moderate | 1 | [
[
[
459,
24,
593
]
],
[
[
459,
24,
1532
],
[
1532,
63,
593
]
],
[
[
459,
23,
126
],
[
126,
24,
593
]
],
[
[
459,
24,
506
],
[
506,
2... | [
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bupropion"
]
],
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
... | Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Bupropion
Ethchlorvynol may cause a minor interaction that can limit clinical effects when taken with Warfarin and Warfa... |
DB00059 | DB00500 | 1,560 | 24 | [
"DDInter1404",
"DDInter1831"
] | Pegaspargase | Tolmetin | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. | Moderate | 1 | [
[
[
1560,
24,
24
]
],
[
[
1560,
24,
886
],
[
886,
1,
24
]
],
[
[
1560,
24,
1062
],
[
1062,
40,
24
]
],
[
[
1560,
24,
477
],
[
477,
6... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolmetin"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ketorolac"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Ketorolac (Compound) resembles Tolmetin (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Tolcapone and Tolcapone (Compound) resembles Tolmetin (Compound)
Pega... |
DB00804 | DB00999 | 1,507 | 504 | [
"DDInter543",
"DDInter883"
] | Dicyclomine | Hydrochlorothiazide | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Hydrochlorothiazide is the most commonly prescribed thiazide diuretic. It is indicated to treat edema and hypertension.[A185138,L8447,L8450] Hydrochlorothiazide use is common but declining in favour of angiotensin converting enzyme inhibitors. Many combination products are available containing hydrochlorothiazide and a... | Minor | 0 | [
[
[
1507,
23,
504
]
],
[
[
1507,
23,
178
],
[
178,
1,
504
]
],
[
[
1507,
62,
323
],
[
323,
40,
504
]
],
[
[
1507,
23,
359
],
[
359,
... | [
[
[
"Dicyclomine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Hydrochlorothiazide"
]
],
[
[
"Dicyclomine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Polythiazide"
],... | Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Polythiazide and Polythiazide (Compound) resembles Hydrochlorothiazide (Compound)
Dicyclomine may cause a minor interaction that can limit clinical effects when taken with Bendroflumethiazide and Bendroflumethiazide (Compound) res... |
DB01225 | DB10672 | 500 | 297 | [
"DDInter645",
"DDInter417"
] | Enoxaparin | Clove | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Clove allergenic extract is used in allergenic testing. | Minor | 0 | [
[
[
500,
23,
297
]
],
[
[
500,
25,
235
],
[
235,
62,
297
]
],
[
[
500,
25,
578
],
[
578,
23,
297
]
],
[
[
500,
64,
366
],
[
366,
23,... | [
[
[
"Enoxaparin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
]
],
[
[
"Enoxaparin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Desirudin"
],
[
"Desirudin",
... | Enoxaparin may lead to a major life threatening interaction when taken with Desirudin and Desirudin may cause a minor interaction that can limit clinical effects when taken with Clove
Enoxaparin may lead to a major life threatening interaction when taken with Ticagrelor and Ticagrelor may cause a minor interaction that... |
DB04948 | DB08868 | 1,084 | 1,011 | [
"DDInter1083",
"DDInter737"
] | Lofexidine | Fingolimod | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1084,
25,
1011
]
],
[
[
1084,
62,
112
],
[
112,
23,
1011
]
],
[
[
1084,
24,
144
],
[
144,
63,
1011
]
],
[
[
1084,
63,
267
],
[
267,
... | [
[
[
"Lofexidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Lofexidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Lofexidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol and Olod... |
DB00771 | DB00844 | 262 | 314 | [
"DDInter397",
"DDInter1257"
] | Clidinium | Nalbuphine | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Moderate | 1 | [
[
[
262,
24,
314
]
],
[
[
262,
63,
828
],
[
828,
40,
314
]
],
[
[
262,
63,
421
],
[
421,
1,
314
]
],
[
[
262,
63,
475
],
[
475,
25,
... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nalbuphine"
]
],
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxycodone"
],
[
... | Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Oxycodone and Oxycodone (Compound) resembles Nalbuphine (Compound)
Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Hydromorphone and Hydromorphone (Compound) resembles Nalbuphine (Compound... |
DB00030 | DB04861 | 1,685 | 1,592 | [
"DDInter934",
"DDInter1271"
] | Insulin human | Nebivolol | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mel... | Nebivolol is a racemic mixture of 2 enantiomers where one is a beta adrenergic antagonist and the other acts as a cardiac stimulant without beta adrenergic activity. Treatment with nebivolol leads to a greater decrease in systolic and diastolic blood pressure than [atenolol], [propranolol], or [pindolol]. Nebivolol and... | Moderate | 1 | [
[
[
1685,
24,
1592
]
],
[
[
1685,
24,
1479
],
[
1479,
23,
1592
]
],
[
[
1685,
24,
1450
],
[
1450,
63,
1592
]
],
[
[
1685,
24,
1445
],
[
14... | [
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nebivolol"
]
],
[
[
"Insulin human",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
... | Insulin human may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a minor interaction that can limit clinical effects when taken with Nebivolol
Insulin human may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB12301 | DB12500 | 907 | 283 | [
"DDInter585",
"DDInter714"
] | Doravirine | Fedratinib | Doravirine is an HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) intended to be administered in combination with other antiretroviral medicines.[L12729,L4562] Doravirine is available by itself or as a combination product of doravirine (100 mg), lamivudine (300 mg), and tenofovir disoproxil fumarate (300 mg... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Minor | 0 | [
[
[
907,
23,
283
]
],
[
[
907,
24,
466
],
[
466,
62,
283
]
],
[
[
907,
62,
351
],
[
351,
23,
283
]
],
[
[
907,
62,
1419
],
[
1419,
2... | [
[
[
"Doravirine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fedratinib"
]
],
[
[
"Doravirine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
... | Doravirine may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Doravirine may cause a minor interaction that can limit clinical effects when taken with Ribociclib and Riboci... |
DB11003 | DB15091 | 748 | 676 | [
"DDInter100",
"DDInter1901"
] | Anthrax vaccine | Upadacitinib | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
748,
24,
676
]
],
[
[
748,
63,
1184
],
[
1184,
25,
676
]
],
[
[
748,
24,
76
],
[
76,
25,
676
]
],
[
[
748,
63,
1184
],
[
1184,
2... | [
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Anthrax vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
]... | Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may lead to a major life threatening interaction when taken with Upadacitinib
Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Mogamulizumab and Mogamulizu... |
DB09154 | DB11828 | 1,475 | 1,406 | [
"DDInter1686",
"DDInter1281"
] | Sodium citrate | Neratinib | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Neratinib was approved in July 2017 for use as an extended adjuvant therapy in Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer. Approval was granted to Puma Biotechnology Inc. for the tradename Nerlynx. Neratinib is currently under investigation for use in many other forms of cancer. | Moderate | 1 | [
[
[
1475,
24,
1406
]
],
[
[
1475,
62,
1252
],
[
1252,
24,
1406
]
],
[
[
1475,
63,
1195
],
[
1195,
24,
1406
]
],
[
[
1475,
64,
115
],
[
115... | [
[
[
"Sodium citrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Neratinib"
]
],
[
[
"Sodium citrate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Digoxin"
],
[
... | Sodium citrate may cause a minor interaction that can limit clinical effects when taken with Digoxin and Digoxin may cause a moderate interaction that could exacerbate diseases when taken with Neratinib
Sodium citrate may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotini... |
DB04938 | DB06404 | 1,423 | 1,514 | [
"DDInter1353",
"DDInter869"
] | Ospemifene | Human C1-esterase inhibitor | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | C1 Esterase Inhibitor (Human) is composed of purified endogenous complement component-1 esterase inhibitor (hC1INH) isolated from human plasma. The primary function of endogenous C1INH is to regulate the activation of the complement and contact system pathways.[L16586, L16606] This drug is indicated for prophylaxis and... | Moderate | 1 | [
[
[
1423,
24,
1514
]
],
[
[
1423,
74,
888
],
[
888,
24,
1514
]
],
[
[
1423,
25,
350
],
[
350,
64,
1514
]
],
[
[
1423,
64,
770
],
[
770,
... | [
[
[
"Ospemifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human C1-esterase inhibitor"
]
],
[
[
"Ospemifene",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate dise... | Ospemifene (Compound) resembles Tamoxifen (Compound) and Ospemifene may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Human C1-esterase inhibitor
Ospemifene may lead to a major life thre... |
DB00327 | DB06209 | 421 | 256 | [
"DDInter890",
"DDInter1508"
] | Hydromorphone | Prasugrel | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
[
421,
24,
256
]
],
[
[
421,
6,
8374
],
[
8374,
45,
256
]
],
[
[
421,
21,
28681
],
[
28681,
60,
256
]
],
[
[
421,
24,
752
],
[
752,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Hydromorphone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compou... | Hydromorphone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Prasugrel (Compound)
Hydromorphone (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Prasugrel (Compound)
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00284 | DB09061 | 1,647 | 1,627 | [
"DDInter11",
"DDInter284"
] | Acarbose | Cannabidiol | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
1647,
24,
1627
]
],
[
[
1647,
24,
609
],
[
609,
23,
1627
]
],
[
[
1647,
24,
1613
],
[
1613,
63,
1627
]
],
[
[
1647,
24,
267
],
[
267,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta... |
DB00497 | DB08865 | 828 | 1,593 | [
"DDInter1366",
"DDInter448"
] | Oxycodone | Crizotinib | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
828,
25,
1593
]
],
[
[
828,
6,
8374
],
[
8374,
45,
1593
]
],
[
[
828,
21,
28771
],
[
28771,
60,
1593
]
],
[
[
828,
25,
283
],
[
283,
... | [
[
[
"Oxycodone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Oxycodone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Crizotini... | Oxycodone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Crizotinib (Compound)
Oxycodone (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused by Crizotinib (Compound)
Oxycodone may lead to a major life threatening interaction when taken with Fedratinib and Fe... |
DB00307 | DB08901 | 1,101 | 1,468 | [
"DDInter202",
"DDInter1492"
] | Bexarotene | Ponatinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
1101,
25,
1468
]
],
[
[
1101,
25,
478
],
[
478,
24,
1468
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
1468
]
],
[
[
1101,
21,
29271
],
[
2927... | [
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Bexarotene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
"{u} may ... | Bexarotene may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ponatinib (Compound)
Bexarotene (Compound) causes Migraine... |
DB00736 | DB01344 | 660 | 1,231 | [
"DDInter676",
"DDInter1830"
] | Esomeprazole | Tolevamer | Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Moderate | 1 | [
[
[
660,
24,
1231
]
],
[
[
660,
24,
1596
],
[
1596,
63,
1231
]
],
[
[
660,
63,
1152
],
[
1152,
24,
1231
]
],
[
[
660,
1,
379
],
[
379,
... | [
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolevamer"
]
],
[
[
"Esomeprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iron"
],
[
... | Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Iron and Iron may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Esomeprazole may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine ... |
DB00377 | DB00543 | 1,494 | 87 | [
"DDInter1382",
"DDInter82"
] | Palonosetron | Amoxapine | Palonosetron (INN, trade name Aloxi) is an antagonist of 5-HT3 receptors that is indicated for the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first... | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Major | 2 | [
[
[
1494,
25,
87
]
],
[
[
1494,
24,
623
],
[
623,
40,
87
]
],
[
[
1494,
64,
695
],
[
695,
40,
87
]
],
[
[
1494,
63,
867
],
[
867,
1,... | [
[
[
"Palonosetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amoxapine"
]
],
[
[
"Palonosetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quetiapine"
],
[
"Quetiap... | Palonosetron may cause a moderate interaction that could exacerbate diseases when taken with Quetiapine and Quetiapine (Compound) resembles Amoxapine (Compound)
Palonosetron may lead to a major life threatening interaction when taken with Clozapine and Clozapine (Compound) resembles Amoxapine (Compound)
Palonosetron ma... |
DB00072 | DB14444 | 550 | 151 | [
"DDInter1846",
"DDInter924"
] | Trastuzumab | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2). It is used as a treatment of human epidermal growth ... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
550,
24,
151
]
],
[
[
550,
24,
66
],
[
66,
24,
151
]
],
[
[
550,
25,
375
],
[
375,
24,
151
]
],
[
[
550,
64,
1057
],
[
1057,
24,... | [
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Trastuzumab",
"{u} may cause a moderate interaction that could... | Trastuzumab may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Trastuzumab may lead to a major life... |
DB00413 | DB01142 | 1,346 | 1,264 | [
"DDInter1505",
"DDInter593"
] | Pramipexole | Doxepin | Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement). It was first approved by the FDA in 1997. Parkinson's Disease is one of the mos... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
1346,
24,
1264
]
],
[
[
1346,
24,
401
],
[
401,
24,
1264
]
],
[
[
1346,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
1346,
24,
649
],
[
649,
... | [
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Pramipexole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Pramipexole may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Dox... |
DB00238 | DB05294 | 188 | 1,069 | [
"DDInter1285",
"DDInter1917"
] | Nevirapine | Vandetanib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Moderate | 1 | [
[
[
188,
24,
1069
]
],
[
[
188,
24,
1195
],
[
1195,
40,
1069
]
],
[
[
188,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
188,
21,
28719
],
[
28719,... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vandetanib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib (Compound) resembles Vandetanib (Compound)
Nevirapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Nevirapine (Compound) causes Pain (Side Effect) and Pain (Side Effec... |
DB01015 | DB01309 | 1,247 | 1,254 | [
"DDInter1724",
"DDInter933"
] | Sulfamethoxazole | Insulin glulisine | Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that interferes with folic acid synthesis in susceptible bacteria. It is generally given in combination with [trimethoprim], which inhibits a sequential step in bacterial folic acid synthesis - these agents work synergistically to block two consecutive steps i... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1247,
24,
1254
]
],
[
[
1247,
24,
1033
],
[
1033,
63,
1254
]
],
[
[
1247,
62,
1424
],
[
1424,
24,
1254
]
],
[
[
1247,
63,
305
],
[
305... | [
[
[
"Sulfamethoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Sulfamethoxazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisi... | Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpelisib may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Quinin... |
DB01377 | DB01602 | 1,283 | 339 | [
"DDInter1119",
"DDInter159"
] | Magnesium oxide | Bacampicillin | Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses. | Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal ac... | Moderate | 1 | [
[
[
1283,
24,
339
]
],
[
[
1283,
63,
1096
],
[
1096,
24,
339
]
],
[
[
1283,
62,
752
],
[
752,
24,
339
]
],
[
[
1283,
24,
286
],
[
286,
... | [
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacampicillin"
]
],
[
[
"Magnesium oxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolic a... | Magnesium oxide may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Bacampicillin
Magnesium oxide may cause a minor interaction that can limit clinical effects when taken w... |
DB00065 | DB00717 | 581 | 1,197 | [
"DDInter923",
"DDInter1312"
] | Infliximab | Norethisterone | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Norethisterone, also known as norethindrone, is a synthetic progestational hormone belonging to the 19-nortestosterone-derived class of progestins. It is further classified as a second-generation progestin, along with [levonorgestrel] and its derivatives, and is the active form of several other progestins including [no... | Moderate | 1 | [
[
[
581,
24,
1197
]
],
[
[
581,
25,
167
],
[
167,
1,
1197
]
],
[
[
581,
24,
566
],
[
566,
40,
1197
]
],
[
[
581,
24,
1657
],
[
1657,
... | [
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Norethisterone"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydrocortisone"
],
[
"Hy... | Infliximab may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Norethisterone (Compound)
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Levonorgestrel and Levonorgestrel (Compound) resembles Norethisterone (C... |
DB00382 | DB00563 | 62 | 663 | [
"DDInter1734",
"DDInter1174"
] | Tacrine | Methotrexate | A centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimer's disease and other central nervous system disorders. Tacrine has been discontinued for the United States market. | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Moderate | 1 | [
[
[
62,
24,
663
]
],
[
[
62,
24,
1487
],
[
1487,
62,
663
]
],
[
[
62,
24,
1154
],
[
1154,
63,
663
]
],
[
[
62,
63,
1560
],
[
1560,
2... | [
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrexate"
]
],
[
[
"Tacrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
],
... | Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroquine and Hydroxychloroquine may cause a minor interaction that can limit clinical effects when taken with Methotrexate
Tacrine may cause a moderate interaction that could exacerbate diseases when taken with Pasireotide... |
DB00543 | DB00747 | 87 | 1,442 | [
"DDInter82",
"DDInter1647"
] | Amoxapine | Scopolamine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Moderate | 1 | [
[
[
87,
24,
1442
]
],
[
[
87,
63,
19
],
[
19,
24,
1442
]
],
[
[
87,
6,
7992
],
[
7992,
45,
1442
]
],
[
[
87,
21,
28766
],
[
28766,
6... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Scopolamine"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Amoxapine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Scopolamine (Compound)
Amoxapine (Compoun... |
DB00719 | DB11632 | 1,219 | 580 | [
"DDInter149",
"DDInter1343"
] | Azatadine | Opicapone | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
1219,
24,
580
]
],
[
[
1219,
40,
830
],
[
830,
24,
580
]
],
[
[
1219,
24,
401
],
[
401,
24,
580
]
],
[
[
1219,
63,
1233
],
[
1233,
... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Azatadine",
"{u} (Compound) resembles {v} (Compound)",
"Phenindamine"
],
[
"Phenindamine",
"{u} may cause a modera... | Azatadine (Compound) resembles Phenindamine (Compound) and Phenindamine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that ... |
DB00701 | DB05239 | 1,091 | 866 | [
"DDInter90",
"DDInter425"
] | Amprenavir | Cobimetinib | Amprenavir is a protease inhibitor used to treat HIV infection. | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
1091,
25,
866
]
],
[
[
1091,
24,
214
],
[
214,
63,
866
]
],
[
[
1091,
63,
1051
],
[
1051,
24,
866
]
],
[
[
1091,
25,
1478
],
[
1478,
... | [
[
[
"Amprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Amprenavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fostama... | Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Amprenavir may cause a moderate interaction that could exacerbate diseases when taken with Aminoglutethimid... |
DB01222 | DB06168 | 617 | 1,531 | [
"DDInter246",
"DDInter281"
] | Budesonide | Canakinumab | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Canakinumab is a recombinant, human anti-human-IL-1β monoclonal antibody that belongs to the IgG1/κ isotype subclass. It is expressed in a murine Sp2/0-Ag14 cell line and comprised of two 447- (or 448-) residue heavy chains and two 214-residue light chains, with a molecular mass of 145157 Daltons when deglycosylated. B... | Moderate | 1 | [
[
[
617,
24,
1531
]
],
[
[
617,
23,
1193
],
[
1193,
62,
1531
]
],
[
[
617,
62,
1461
],
[
1461,
23,
1531
]
],
[
[
617,
24,
1270
],
[
1270,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
]
],
[
[
"Budesonide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[... | Budesonide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Canakinumab
Budesonide may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vita... |
DB00563 | DB11979 | 663 | 1,320 | [
"DDInter1174",
"DDInter625"
] | Methotrexate | Elagolix | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Moderate | 1 | [
[
[
663,
24,
1320
]
],
[
[
663,
63,
168
],
[
168,
23,
1320
]
],
[
[
663,
24,
1612
],
[
1612,
23,
1320
]
],
[
[
663,
63,
79
],
[
79,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Elagolix"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Elagolix
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir and Foste... |
DB00331 | DB00687 | 1,645 | 870 | [
"DDInter1164",
"DDInter747"
] | Metformin | Fludrocortisone | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
1645,
24,
870
]
],
[
[
1645,
24,
1220
],
[
1220,
40,
870
]
],
[
[
1645,
24,
443
],
[
443,
24,
870
]
],
[
[
1645,
62,
1103
],
[
1103,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Metformin may cause a moderate interaction that could exacerbate diseases when taken with Spironolactone and Spironolactone may cause a moderate inter... |
DB00321 | DB01041 | 21 | 770 | [
"DDInter78",
"DDInter1789"
] | Amitriptyline | Thalidomide | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, thalidomide was withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of inflammatory disorders and cancers. Thalidomide displays immunosuppressive and anti-angiogenic activity through modulating ... | Moderate | 1 | [
[
[
21,
24,
770
]
],
[
[
21,
6,
6365
],
[
6365,
45,
770
]
],
[
[
21,
21,
28789
],
[
28789,
60,
770
]
],
[
[
21,
24,
609
],
[
609,
63... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
]
],
[
[
"Amitriptyline",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Comp... | Amitriptyline (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Thalidomide (Compound)
Amitriptyline (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Thalidomide (Compound)
Amitriptyline may cause a moderate interaction that could exacerbate diseases ... |
DB00333 | DB06663 | 576 | 1,154 | [
"DDInter1166",
"DDInter1398"
] | Methadone | Pasireotide | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
576,
25,
1154
]
],
[
[
576,
63,
1314
],
[
1314,
40,
1154
]
],
[
[
576,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
576,
23,
112
],
[
112,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Desmopressin"
],
[
"Desmopres... | Methadone may cause a moderate interaction that could exacerbate diseases when taken with Desmopressin and Desmopressin (Compound) resembles Pasireotide (Compound)
Methadone (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Methadone may cause a minor in... |
DB00653 | DB09407 | 544 | 853 | [
"DDInter1120",
"DDInter1114"
] | Magnesium sulfate | Magnesium chloride | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Magnesium chloride salts are highly soluble in water and the hydrated form of magnesium chloride can be extracted from brine or sea water. | Moderate | 1 | [
[
[
544,
24,
853
]
],
[
[
544,
24,
1539
],
[
1539,
24,
853
]
],
[
[
544,
63,
964
],
[
964,
24,
853
]
],
[
[
544,
24,
460
],
[
460,
6... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium chloride"
]
],
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oflox... | Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Ofloxacin and Ofloxacin may cause a moderate interaction that could exacerbate diseases when taken with Magnesium chloride
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with D... |
DB00358 | DB00996 | 1,010 | 1,198 | [
"DDInter1140",
"DDInter791"
] | Mefloquine | Gabapentin | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993. It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to tr... | Moderate | 1 | [
[
[
1010,
24,
1198
]
],
[
[
1010,
6,
4349
],
[
4349,
45,
1198
]
],
[
[
1010,
21,
28942
],
[
28942,
60,
1198
]
],
[
[
1010,
24,
286
],
[
28... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gabapentin"
]
],
[
[
"Mefloquine",
"{u} (Compound) binds {v} (Gene)",
"ADORA1"
],
[
"ADORA1",
"{u} (Gene) is bound by {v} (Compound)",... | Mefloquine (Compound) binds ADORA1 (Gene) and ADORA1 (Gene) is bound by Gabapentin (Compound)
Mefloquine (Compound) causes Dermatitis bullous (Side Effect) and Dermatitis bullous (Side Effect) is caused by Gabapentin (Compound)
Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with M... |
DB00370 | DB01064 | 1,251 | 1,148 | [
"DDInter1230",
"DDInter987"
] | Mirtazapine | Isoprenaline | Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994. This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.[T595, L6... | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Moderate | 1 | [
[
[
1251,
24,
1148
]
],
[
[
1251,
24,
480
],
[
480,
24,
1148
]
],
[
[
1251,
6,
1704
],
[
1704,
45,
1148
]
],
[
[
1251,
21,
29316
],
[
2931... | [
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
]
],
[
[
"Mirtazapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Formoterol"
],
... | Mirtazapine may cause a moderate interaction that could exacerbate diseases when taken with Formoterol and Formoterol may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline
Mirtazapine (Compound) binds ADRB1 (Gene) and ADRB1 (Gene) is bound by Isoprenaline (Compound)
Mirtazapine (C... |
DB00041 | DB06691 | 1,648 | 849 | [
"DDInter38",
"DDInter1155"
] | Aldesleukin | Mepyramine | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1648,
24,
849
]
],
[
[
1648,
24,
1594
],
[
1594,
24,
849
]
],
[
[
1648,
25,
770
],
[
770,
24,
849
]
],
[
[
1648,
24,
407
],
[
407,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Aldesleukin may lead to a major life threatening interaction when taken with Thalidomide and Thalidomide may ca... |
DB00855 | DB08881 | 213 | 868 | [
"DDInter72",
"DDInter1925"
] | Aminolevulinic acid | Vemurafenib | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Major | 2 | [
[
[
213,
25,
868
]
],
[
[
213,
18,
2099
],
[
2099,
46,
868
]
],
[
[
213,
7,
8924
],
[
8924,
46,
868
]
],
[
[
213,
18,
17504
],
[
17504,
... | [
[
[
"Aminolevulinic acid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vemurafenib"
]
],
[
[
"Aminolevulinic acid",
"{u} (Compound) downregulates {v} (Gene)",
"TP53"
],
[
"TP53",
"{u} (Gene) is upregulated by {v... | Aminolevulinic acid (Compound) downregulates TP53 (Gene) and TP53 (Gene) is upregulated by Vemurafenib (Compound)
Aminolevulinic acid (Compound) upregulates SPAG4 (Gene) and SPAG4 (Gene) is upregulated by Vemurafenib (Compound)
Aminolevulinic acid (Compound) downregulates TMEM109 (Gene) and TMEM109 (Gene) is downregula... |
DB00422 | DB08824 | 895 | 591 | [
"DDInter1189",
"DDInter959"
] | Methylphenidate | Ioflupane I-123 | Methylphenidate is a central nervous system stimulant used most commonly in the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) and for narcolepsy. Also known as the marketed products Ritalin, Concerta, or Biphentin, methylphenidate is used with other treatment modalities (psychological, educational, cogni... | Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes. | Moderate | 1 | [
[
[
895,
24,
591
]
],
[
[
895,
6,
2437
],
[
2437,
45,
591
]
],
[
[
895,
21,
28734
],
[
28734,
60,
591
]
],
[
[
895,
1,
1177
],
[
1177,
... | [
[
[
"Methylphenidate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioflupane I-123"
]
],
[
[
"Methylphenidate",
"{u} (Compound) binds {v} (Gene)",
"SLC6A3"
],
[
"SLC6A3",
"{u} (Gene) is bound by {... | Methylphenidate (Compound) binds SLC6A3 (Gene) and SLC6A3 (Gene) is bound by Ioflupane I-123 (Compound)
Methylphenidate (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Ioflupane I-123 (Compound)
Methylphenidate (Compound) resembles Dexmethylphenidate (Compoun... |
DB00108 | DB00635 | 1,066 | 1,573 | [
"DDInter1268",
"DDInter1515"
] | Natalizumab | Prednisone | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Major | 2 | [
[
[
1066,
25,
1573
]
],
[
[
1066,
25,
175
],
[
175,
40,
1573
]
],
[
[
1066,
25,
251
],
[
251,
1,
1573
]
],
[
[
1066,
23,
1461
],
[
1461,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Prednisone"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone",
... | Natalizumab may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Prednisone (Compound)
Natalizumab may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone (Compound) resembles Prednisone (Compound)
Natalizumab may ... |
DB00092 | DB12001 | 58 | 564 | [
"DDInter40",
"DDInter7"
] | Alefacept | Abemaciclib | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
58,
24,
564
]
],
[
[
58,
24,
748
],
[
748,
24,
564
]
],
[
[
58,
24,
151
],
[
151,
63,
564
]
],
[
[
58,
63,
599
],
[
599,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
],
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine and Anthrax vaccine may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Influenza A ... |
DB00176 | DB12364 | 529 | 1,421 | [
"DDInter770",
"DDInter200"
] | Fluvoxamine | Betrixaban | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
529,
24,
1421
]
],
[
[
529,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
529,
25,
1406
],
[
1406,
24,
1421
]
],
[
[
529,
24,
714
],
[
714,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Fluvoxamine may lead to a major life threatening interaction when taken with Neratinib and Neratinib may cause ... |
DB00514 | DB11732 | 506 | 1,097 | [
"DDInter527",
"DDInter1027"
] | Dextromethorphan | Lasmiditan | Dextromethorphan is a levorphanol derivative and codeine analog commonly used as a cough suppressant and also a drug of abuse. Although similar in structure to other opioids, it has minimal interaction with opioid receptors. Dextromethorphan was granted FDA approval before 3 December 1957.[A215412,L14997] | Lasmiditan is an oral medication used in the termination of migraine headaches that was first approved for use in the United States in October 2019.[L9338,L9356] It was also approved by the European Commission on August 17, 2022. Traditionally, the triptan class of anti-migraine medications (e.g. [sumatriptan]) have se... | Major | 2 | [
[
[
506,
25,
1097
]
],
[
[
506,
63,
701
],
[
701,
24,
1097
]
],
[
[
506,
24,
478
],
[
478,
24,
1097
]
],
[
[
506,
25,
1053
],
[
1053,
... | [
[
[
"Dextromethorphan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lasmiditan"
]
],
[
[
"Dextromethorphan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Lasmiditan
Dextromethorphan may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib... |
DB06176 | DB12332 | 1,342 | 1,619 | [
"DDInter1616",
"DDInter1626"
] | Romidepsin | Rucaparib | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
1342,
24,
1619
]
],
[
[
1342,
62,
112
],
[
112,
23,
1619
]
],
[
[
1342,
24,
259
],
[
259,
24,
1619
]
],
[
[
1342,
24,
151
],
[
151,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept and Rilon... |
DB01100 | DB04868 | 1,568 | 478 | [
"DDInter1470",
"DDInter1293"
] | Pimozide | Nilotinib | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Major | 2 | [
[
[
1568,
25,
478
]
],
[
[
1568,
6,
4973
],
[
4973,
45,
478
]
],
[
[
1568,
7,
6717
],
[
6717,
46,
478
]
],
[
[
1568,
18,
2183
],
[
2183,
... | [
[
[
"Pimozide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
]
],
[
[
"Pimozide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Nilotinib"
... | Pimozide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Nilotinib (Compound)
Pimozide (Compound) upregulates HERPUD1 (Gene) and HERPUD1 (Gene) is upregulated by Nilotinib (Compound)
Pimozide (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Nilotinib (Compound)
Pimozide (Compound) u... |
DB00836 | DB06636 | 543 | 1,623 | [
"DDInter1088",
"DDInter980"
] | Loperamide | Isavuconazonium | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
543,
24,
1623
]
],
[
[
543,
63,
1557
],
[
1557,
24,
1623
]
],
[
[
543,
24,
1487
],
[
1487,
24,
1623
]
],
[
[
543,
64,
1424
],
[
1424,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
],
... | Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Hydroxychloroqui... |
DB00563 | DB01017 | 663 | 1,669 | [
"DDInter1174",
"DDInter1224"
] | Methotrexate | Minocycline | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Moderate | 1 | [
[
[
663,
24,
1669
]
],
[
[
663,
24,
1572
],
[
1572,
1,
1669
]
],
[
[
663,
63,
964
],
[
964,
1,
1669
]
],
[
[
663,
24,
1545
],
[
1545,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Minocycline"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Demeclocycline"
],... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline (Compound) resembles Minocyc... |
DB00802 | DB12130 | 1,322 | 1,017 | [
"DDInter43",
"DDInter1094"
] | Alfentanil | Lorlatinib | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Lorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA in 2019 for the treatment of select patients with previously treated advanced ALK-... | Moderate | 1 | [
[
[
1322,
24,
1017
]
],
[
[
1322,
62,
608
],
[
608,
23,
1017
]
],
[
[
1322,
63,
1101
],
[
1101,
23,
1017
]
],
[
[
1322,
24,
976
],
[
976,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
]
],
[
[
"Alfentanil",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Lidocaine"
],
[
... | Alfentanil may cause a minor interaction that can limit clinical effects when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Lorlatinib
Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene m... |
DB06176 | DB06636 | 1,342 | 1,623 | [
"DDInter1616",
"DDInter980"
] | Romidepsin | Isavuconazonium | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
1342,
24,
1623
]
],
[
[
1342,
63,
1557
],
[
1557,
24,
1623
]
],
[
[
1342,
64,
1487
],
[
1487,
24,
1623
]
],
[
[
1342,
25,
1593
],
[
15... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
],
... | Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Astemizole and Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Romidepsin may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxyc... |
DB01030 | DB09052 | 869 | 250 | [
"DDInter1835",
"DDInter220"
] | Topotecan | Blinatumomab | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Blinatumomab is a BiTE-class (bi-specific T-cell engager) constructed monoclonal antibody formed by the recombinant fusion of an anti-CD3 single-chain variable fragment (scFV) and an anti-CD19 scFV through a short peptide linker.[A254836,L44311] CD3 is an antigen expressed on the surface of T-cells, while CD19 is mostl... | Moderate | 1 | [
[
[
869,
24,
250
]
],
[
[
869,
24,
949
],
[
949,
63,
250
]
],
[
[
869,
63,
599
],
[
599,
24,
250
]
],
[
[
869,
24,
850
],
[
850,
24,... | [
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Blinatumomab"
]
],
[
[
"Topotecan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid a... | Topotecan may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated) and Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab
Topotecan m... |
DB01263 | DB12015 | 859 | 1,033 | [
"DDInter1494",
"DDInter53"
] | Posaconazole | Alpelisib | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Alpelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor with potent antitumor activity. It works by selectively inhibiting class I PI3K p110α , which is the catalytic subunit of PI3K, a lipid kinase that plays a role in various biological processes, including proliferation, survival, differentiation, and metaboli... | Moderate | 1 | [
[
[
859,
24,
1033
]
],
[
[
859,
25,
1135
],
[
1135,
23,
1033
]
],
[
[
859,
25,
951
],
[
951,
24,
1033
]
],
[
[
859,
63,
322
],
[
322,
... | [
[
[
"Posaconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alpelisib"
]
],
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxego... | Posaconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Alpelisib
Posaconazole may lead to a major life threatening interaction when taken with Palbociclib and Palbociclib may cause a moderate int... |
DB08826 | DB15699 | 1,292 | 652 | [
"DDInter489",
"DDInter232"
] | Deferiprone | Brexucabtagene autoleucel | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Major | 2 | [
[
[
1292,
25,
652
]
],
[
[
1292,
64,
4
],
[
4,
24,
652
]
],
[
[
1292,
25,
738
],
[
738,
24,
652
]
],
[
[
1292,
25,
976
],
[
976,
25,... | [
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Deferiprone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Omacetaxine mepesuccinate"
],
[
... | Deferiprone may lead to a major life threatening interaction when taken with Omacetaxine mepesuccinate and Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Deferiprone may lead to a major life threatening interaction when taken with Nira... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.