drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00188 | DB01319 | 168 | 34 | [
"DDInter222",
"DDInter777"
] | Bortezomib | Fosamprenavir | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Moderate | 1 | [
[
[
168,
24,
34
]
],
[
[
168,
24,
1091
],
[
1091,
40,
34
]
],
[
[
168,
6,
8374
],
[
8374,
45,
34
]
],
[
[
168,
21,
29062
],
[
29062,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosamprenavir"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amprenavir"
],
[... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Amprenavir and Amprenavir (Compound) resembles Fosamprenavir (Compound)
Bortezomib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Fosamprenavir (Compound)
Bortezomib (Compound) causes Neutropenia (Side Effect) and N... |
DB01010 | DB01019 | 61 | 427 | [
"DDInter622",
"DDInter199"
] | Edrophonium | Bethanechol | A rapid-onset, short-acting cholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. It has also been used as an antidote to curare principles. | Bethanechol is a synthetic ester that was initially synthesized in 1935.[A232905,L32539] As a cholinergic agent, bethanechol is similar in structure and pharmacological function to acetylcholine and is used in specific cases when stimulation of the parasympathetic nervous system is necessary.[A232905,L32539] For exampl... | Moderate | 1 | [
[
[
61,
24,
427
]
],
[
[
61,
21,
29668
],
[
29668,
60,
427
]
],
[
[
61,
63,
1442
],
[
1442,
24,
427
]
],
[
[
61,
24,
1511
],
[
1511,
... | [
[
[
"Edrophonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bethanechol"
]
],
[
[
"Edrophonium",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal cramps"
],
[
"Abdominal cramps",
"{u} (Sid... | Edrophonium (Compound) causes Abdominal cramps (Side Effect) and Abdominal cramps (Side Effect) is caused by Bethanechol (Compound)
Edrophonium may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and Scopolamine may cause a moderate interaction that could exacerbate diseases when... |
DB00687 | DB12010 | 870 | 214 | [
"DDInter747",
"DDInter785"
] | Fludrocortisone | Fostamatinib | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
870,
24,
214
]
],
[
[
870,
25,
976
],
[
976,
24,
214
]
],
[
[
870,
63,
1428
],
[
1428,
24,
214
]
],
[
[
870,
1,
1573
],
[
1573,
... | [
[
[
"Fludrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Fludrocortisone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tofacitinib"
],
[
... | Fludrocortisone may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isradip... |
DB00848 | DB01610 | 281 | 248 | [
"DDInter1044",
"DDInter1912"
] | Levamisole | Valganciclovir | Levamisole is an antihelminthic drug that was commonly used for the treatment of parasitic, viral, and bacterial infections. It was manufactured by _Janssen_ and first used in 1969 as an agent to treat worm infestations Levamisole was approved by the FDA in 1990 as an adjuvant treatment for colon cancer. Prior to this,... | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Moderate | 1 | [
[
[
281,
24,
248
]
],
[
[
281,
24,
563
],
[
563,
1,
248
]
],
[
[
281,
25,
507
],
[
507,
63,
248
]
],
[
[
281,
24,
738
],
[
738,
63,
... | [
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valganciclovir"
]
],
[
[
"Levamisole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ganciclovir"
],
... | Levamisole may cause a moderate interaction that could exacerbate diseases when taken with Ganciclovir and Ganciclovir (Compound) resembles Valganciclovir (Compound)
Levamisole may lead to a major life threatening interaction when taken with Samarium (153Sm) lexidronam and Samarium (153Sm) lexidronam may cause a modera... |
DB00254 | DB01060 | 964 | 319 | [
"DDInter598",
"DDInter83"
] | Doxycycline | Amoxicillin | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin. Amoxicillin was granted FDA approval on 18 January 1974. | Moderate | 1 | [
[
[
964,
24,
319
]
],
[
[
964,
24,
1249
],
[
1249,
40,
319
]
],
[
[
964,
24,
950
],
[
950,
1,
319
]
],
[
[
964,
6,
10612
],
[
10612,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amoxicillin"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
[
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Amoxicillin (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Cloxacillin and Cloxacillin (Compound) resembles Amoxicillin (Compou... |
DB00307 | DB09054 | 1,101 | 384 | [
"DDInter202",
"DDInter905"
] | Bexarotene | Idelalisib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
1101,
24,
384
]
],
[
[
1101,
24,
1627
],
[
1627,
62,
384
]
],
[
[
1101,
25,
464
],
[
464,
62,
384
]
],
[
[
1101,
23,
555
],
[
555,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
],
[
... | Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Bexarotene may lead to a major life threatening interaction when taken with Eravacycline and Eravacycline may ca... |
DB00774 | DB01276 | 1,577 | 123 | [
"DDInter889",
"DDInter706"
] | Hydroflumethiazide | Exenatide | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822) | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
1577,
24,
123
]
],
[
[
1577,
24,
708
],
[
708,
63,
123
]
],
[
[
1577,
63,
1573
],
[
1573,
24,
123
]
],
[
[
1577,
1,
323
],
[
323,
... | [
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Hydroflumethiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropi... | Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Hydroflumethiazide may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00988 | DB09082 | 817 | 659 | [
"DDInter584",
"DDInter1934"
] | Dopamine | Vilanterol | One of the catecholamine neurotransmitters in the brain. It is derived from tyrosine and is the precursor to norepinephrine and epinephrine. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (receptors, dopamine) mediate its action. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
817,
24,
659
]
],
[
[
817,
24,
1296
],
[
1296,
63,
659
]
],
[
[
817,
24,
1450
],
[
1450,
24,
659
]
],
[
[
817,
25,
1264
],
[
1264,
... | [
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Dopamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
],
[
... | Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol
Dopamine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin... |
DB01165 | DB08865 | 1,539 | 1,593 | [
"DDInter1325",
"DDInter448"
] | Ofloxacin | Crizotinib | A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Major | 2 | [
[
[
1539,
25,
1593
]
],
[
[
1539,
18,
4718
],
[
4718,
46,
1593
]
],
[
[
1539,
6,
3199
],
[
3199,
57,
1593
]
],
[
[
1539,
21,
28771
],
[
28... | [
[
[
"Ofloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
]
],
[
[
"Ofloxacin",
"{u} (Compound) downregulates {v} (Gene)",
"KIAA0196"
],
[
"KIAA0196",
"{u} (Gene) is upregulated by {v} (Compound)"... | Ofloxacin (Compound) downregulates KIAA0196 (Gene) and KIAA0196 (Gene) is upregulated by Crizotinib (Compound)
Ofloxacin (Compound) binds TOP2A (Gene) and TOP2A (Gene) is downregulated by Crizotinib (Compound)
Ofloxacin (Compound) causes Respiratory failure (Side Effect) and Respiratory failure (Side Effect) is caused ... |
DB00497 | DB01183 | 828 | 173 | [
"DDInter1366",
"DDInter1262"
] | Oxycodone | Naloxone | Oxycodone is a semisynthetic opioid analgesic derived from thebaine in Germany in 1917. It is currently indicated as an immediate release product for moderate to severe pain and as an extended release product for chronic moderate to severe pain requiring continuous opioid analgesics for an extended period.[Label] The f... | Naloxone is an opioid antagonist medication used to block or reverse the effects of opioid drugs, particularly within the setting of drug overdoses which are rapidly becoming a leading cause of death worldwide. More specifically, naloxone has a high affinity for μ-opioid receptors, where it acts as an inverse agonist, ... | Moderate | 1 | [
[
[
828,
24,
173
]
],
[
[
828,
40,
314
],
[
314,
24,
173
]
],
[
[
828,
1,
1235
],
[
1235,
40,
173
]
],
[
[
828,
64,
475
],
[
475,
24... | [
[
[
"Oxycodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxone"
]
],
[
[
"Oxycodone",
"{u} (Compound) resembles {v} (Compound)",
"Nalbuphine"
],
[
"Nalbuphine",
"{u} may cause a moderate in... | Oxycodone (Compound) resembles Nalbuphine (Compound) and Nalbuphine may cause a moderate interaction that could exacerbate diseases when taken with Naloxone
Oxycodone (Compound) resembles Hydrocodone (Compound) and Hydrocodone (Compound) resembles Naloxone (Compound)
Oxycodone may lead to a major life threatening inter... |
DB01233 | DB01246 | 1,311 | 820 | [
"DDInter1197",
"DDInter45"
] | Metoclopramide | Alimemazine | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | A phenothiazine derivative that is used as an antipruritic. | Major | 2 | [
[
[
1311,
25,
820
]
],
[
[
1311,
63,
358
],
[
358,
24,
820
]
],
[
[
1311,
64,
104
],
[
104,
40,
820
]
],
[
[
1311,
64,
401
],
[
401,
... | [
[
[
"Metoclopramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
]
],
[
[
"Metoclopramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
],
[
... | Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Orphenadrine and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Metoclopramide may lead to a major life threatening interaction when taken with Methdilazine and Methdi... |
DB00056 | DB10795 | 816 | 221 | [
"DDInter814",
"DDInter1486"
] | Gemtuzumab ozogamicin | Poliovirus type 1 antigen (formaldehyde inactivated) | Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheami... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
816,
24,
221
]
],
[
[
816,
25,
581
],
[
581,
24,
221
]
],
[
[
816,
24,
599
],
[
599,
24,
221
]
],
[
[
816,
63,
305
],
[
305,
24,... | [
[
[
"Gemtuzumab ozogamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Gemtuzumab ozogamicin",
"{u} may lead to a major life threatening interaction when ta... | Gemtuzumab ozogamicin may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Gemtuzumab ozogamicin may cause a moderate interaction that could exacerba... |
DB01263 | DB08820 | 859 | 1,478 | [
"DDInter1494",
"DDInter997"
] | Posaconazole | Ivacaftor | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Major | 2 | [
[
[
859,
25,
1478
]
],
[
[
859,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
859,
21,
30495
],
[
30495,
60,
1478
]
],
[
[
859,
25,
1135
],
[
1135,... | [
[
[
"Posaconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivacaftor"
]
],
[
[
"Posaconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Ivac... | Posaconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Posaconazole (Compound) causes Pleuritic pain (Side Effect) and Pleuritic pain (Side Effect) is caused by Ivacaftor (Compound)
Posaconazole may lead to a major life threatening interaction when taken with Naloxegol and Naloxe... |
DB06595 | DB14840 | 1,491 | 861 | [
"DDInter1214",
"DDInter1601"
] | Midostaurin | Ripretinib | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Ripretinib is a kinase inhibitor used for the treatment of advanced gastrointestinal stromal tumor (GIST) that has not adequately responded to other kinase inhibitors such as [sunitinib] and [imatinib]. Ripretinib, also known as Qinlock, is manufactured by Deciphera Pharmaceuticals and was initially approved by the FDA... | Moderate | 1 | [
[
[
1491,
24,
861
]
],
[
[
1491,
24,
351
],
[
351,
24,
861
]
],
[
[
1491,
63,
353
],
[
353,
24,
861
]
],
[
[
1491,
25,
1456
],
[
1456,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ripretinib"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a moderate interaction that could exacerbate diseases when taken with Ripretinib
Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Griseofulvin and Gr... |
DB01005 | DB01177 | 995 | 77 | [
"DDInter894",
"DDInter904"
] | Hydroxyurea | Idarubicin | Hydroxyurea is a non-alkylating antineoplastic agent that was first synthesized in 1869 but was not characterized biologically until 1928. It was first approved by the FDA in 1998 for the treatment of sickle cell anemia in adults. Although clinical evidence on the efficacy of hydroxyurea in certain conditions exists, h... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
995,
24,
77
]
],
[
[
995,
5,
11555
],
[
11555,
44,
77
]
],
[
[
995,
6,
12523
],
[
12523,
45,
77
]
],
[
[
995,
21,
28931
],
[
28931,
... | [
[
[
"Hydroxyurea",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Hydroxyurea",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Dise... | Hydroxyurea (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Idarubicin (Compound)
Hydroxyurea (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Idarubicin (Compound)
Hydroxyurea (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused b... |
DB00734 | DB00741 | 1,664 | 167 | [
"DDInter1605",
"DDInter885"
] | Risperidone | Hydrocortisone | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
1664,
24,
167
]
],
[
[
1664,
63,
870
],
[
870,
1,
167
]
],
[
[
1664,
6,
8374
],
[
8374,
45,
167
]
],
[
[
1664,
21,
28642
],
[
28642,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydrocortisone (Compound)
Risperidone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Hydrocortisone (Compound)
Risperidone (Compound) causes Shock (Side Effe... |
DB01064 | DB14754 | 1,148 | 1,663 | [
"DDInter987",
"DDInter1697"
] | Isoprenaline | Solriamfetol | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label]. | Moderate | 1 | [
[
[
1148,
24,
1663
]
],
[
[
1148,
74,
1674
],
[
1674,
24,
1663
]
],
[
[
1148,
24,
659
],
[
659,
24,
1663
]
],
[
[
1148,
63,
455
],
[
455,
... | [
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solriamfetol"
]
],
[
[
"Isoprenaline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when t... | Isoprenaline (Compound) resembles Orciprenaline (Compound) and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Solriamfetol
Isoprenaline may cause a moderate inter... |
DB00349 | DB00358 | 902 | 1,010 | [
"DDInter401",
"DDInter1140"
] | Clobazam | Mefloquine | Clobazam belongs to the 1,5-benzodiazepine class of drugs and is marketed under different names, Onfi, Frisium, Urbanyl, and others.. Clobazam was first synthesized in 1966 and first published in 1969, following the incidental synthesis and discovery of the first benzodiazepine chlordiazepoxide in the 1950s. Unlike old... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
902,
24,
1010
]
],
[
[
902,
6,
8374
],
[
8374,
45,
1010
]
],
[
[
902,
21,
28817
],
[
28817,
60,
1010
]
],
[
[
902,
24,
1311
],
[
1311,... | [
[
[
"Clobazam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Clobazam",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Clobazam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mefloquine (Compound)
Clobazam (Compound) causes Vision blurred (Side Effect) and Vision blurred (Side Effect) is caused by Mefloquine (Compound)
Clobazam may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide ... |
DB00831 | DB09472 | 1,178 | 1,383 | [
"DDInter1866",
"DDInter1693"
] | Trifluoperazine | Sodium sulfate | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1178,
24,
1383
]
],
[
[
1178,
24,
609
],
[
609,
24,
1383
]
],
[
[
1178,
1,
146
],
[
146,
24,
1383
]
],
[
[
1178,
25,
1311
],
[
1311,
... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromyci... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Trifluoperazine (Compound) resembles Propiomazine (Compound) and Propiomazine may cause a moder... |
DB00214 | DB00994 | 1,028 | 361 | [
"DDInter1836",
"DDInter1277"
] | Torasemide | Neomycin | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Major | 2 | [
[
[
1028,
25,
361
]
],
[
[
1028,
24,
1647
],
[
1647,
24,
361
]
],
[
[
1028,
21,
28722
],
[
28722,
60,
361
]
],
[
[
1028,
24,
355
],
[
355,... | [
[
[
"Torasemide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Neomycin"
]
],
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
"Acarbose",
... | Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Neomycin
Torasemide (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Neomycin (Compound)
Torasemide... |
DB09020 | DB14881 | 28 | 180 | [
"DDInter212",
"DDInter1329"
] | Bisacodyl | Oliceridine | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
28,
24,
180
]
],
[
[
28,
24,
124
],
[
124,
24,
180
]
],
[
[
28,
63,
618
],
[
618,
24,
180
]
],
[
[
28,
40,
100
],
[
100,
24,
... | [
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Bisacodyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glasdegib"
],
[
... | Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glasdegib may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Bisacodyl may cause a moderate interaction that could exacerbate diseases when taken with Abarelix and Abarelix ma... |
DB09330 | DB11601 | 985 | 1,270 | [
"DDInter1352",
"DDInter1889"
] | Osimertinib | Tuberculin purified protein derivative | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
985,
24,
1270
]
],
[
[
985,
63,
1531
],
[
1531,
24,
1270
]
],
[
[
985,
64,
1064
],
[
1064,
24,
1270
]
],
[
[
985,
24,
119
],
[
119,
... | [
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Osimertinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Osimertinib may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Osimertinib may lead to a major life threatening interaction when taken with Clad... |
DB00798 | DB01212 | 1,132 | 1,453 | [
"DDInter815",
"DDInter334"
] | Gentamicin | Ceftriaxone | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse ac... | Moderate | 1 | [
[
[
1132,
24,
1453
]
],
[
[
1132,
24,
1024
],
[
1024,
40,
1453
]
],
[
[
1132,
63,
149
],
[
149,
40,
1453
]
],
[
[
1132,
24,
1227
],
[
1227... | [
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ceftriaxone"
]
],
[
[
"Gentamicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
],
[
... | Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Cefpodoxime and Cefpodoxime (Compound) resembles Ceftriaxone (Compound)
Gentamicin may cause a moderate interaction that could exacerbate diseases when taken with Ceftazidime and Ceftazidime (Compound) resembles Ceftriaxone (Comp... |
DB01285 | DB08880 | 708 | 1,510 | [
"DDInter445",
"DDInter1771"
] | Corticotropin | Teriflunomide | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Major | 2 | [
[
[
708,
25,
1510
]
],
[
[
708,
24,
221
],
[
221,
63,
1510
]
],
[
[
708,
24,
1136
],
[
1136,
24,
1510
]
],
[
[
708,
63,
1144
],
[
1144,
... | [
[
[
"Corticotropin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Teriflunomide"
]
],
[
[
"Corticotropin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formal... | Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated) and Poliovirus type 1 antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Teriflunomide
Corticotropin may caus... |
DB00599 | DB01142 | 682 | 1,264 | [
"DDInter1795",
"DDInter593"
] | Thiopental | Doxepin | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
682,
24,
1264
]
],
[
[
682,
23,
401
],
[
401,
24,
1264
]
],
[
[
682,
63,
1594
],
[
1594,
24,
1264
]
],
[
[
682,
24,
649
],
[
649,
... | [
[
[
"Thiopental",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Thiopental",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Promethazine"
],
[
... | Thiopental may cause a minor interaction that can limit clinical effects when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylam... |
DB00867 | DB00907 | 1,052 | 290 | [
"DDInter1606",
"DDInter427"
] | Ritodrine | Cocaine (topical) | Adrenergic beta-agonist used to control premature labor. | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Major | 2 | [
[
[
1052,
25,
290
]
],
[
[
1052,
24,
455
],
[
455,
64,
290
]
],
[
[
1052,
1,
532
],
[
532,
25,
290
]
],
[
[
1052,
35,
480
],
[
480,
... | [
[
[
"Ritodrine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cocaine"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
[
"Salmeterol",
... | Ritodrine may lead to a major life threatening interaction when taken with Cocaine
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may lead to a major life threatening interaction when taken with Cocaine
Ritodrine (Compound) resembles Dobutamine (Compo... |
DB00224 | DB08896 | 215 | 292 | [
"DDInter917",
"DDInter1576"
] | Indinavir | Regorafenib | A potent and specific HIV protease inhibitor that appears to have good oral bioavailability. [PubChem] | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
215,
24,
292
]
],
[
[
215,
6,
6017
],
[
6017,
45,
292
]
],
[
[
215,
21,
28890
],
[
28890,
60,
292
]
],
[
[
215,
24,
549
],
[
549,
... | [
[
[
"Indinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Indinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Indinavir (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Regorafenib (Compound)
Indinavir (Compound) causes Myocardial infarction (Side Effect) and Myocardial infarction (Side Effect) is caused by Regorafenib (Compound)
Indinavir may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00549 | DB01098 | 522 | 14 | [
"DDInter1955",
"DDInter1622"
] | Zafirlukast | Rosuvastatin | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Rosuvastatin, also known as the brand name product Crestor, is a lipid-lowering drug that belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage elevated lipid levels by inhibiting the endogenous production of cholesterol in the liver. More specifically, statin... | Moderate | 1 | [
[
[
522,
24,
14
]
],
[
[
522,
24,
671
],
[
671,
24,
14
]
],
[
[
522,
6,
8374
],
[
8374,
45,
14
]
],
[
[
522,
21,
28698
],
[
28698,
6... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rosuvastatin"
]
],
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Zafirlukast may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Rosuvastatin
Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rosuvastatin (Compound)
Zafirlukas... |
DB00264 | DB08938 | 88 | 1,384 | [
"DDInter1200",
"DDInter1112"
] | Metoprolol | Magaldrate | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
88,
23,
1384
]
],
[
[
88,
24,
167
],
[
167,
23,
1384
]
],
[
[
88,
40,
887
],
[
887,
23,
1384
]
],
[
[
88,
1,
819
],
[
819,
23,
... | [
[
[
"Metoprolol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
],
[
... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Metoprolol (Compound) resembles Pindolol (Compound) and Pindolol may cause a minor interaction that can li... |
DB00031 | DB00775 | 20 | 1,226 | [
"DDInter1764",
"DDInter1818"
] | Tenecteplase | Tirofiban | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Tirofiban prevents the blood from clotting during episodes of chest pain or a heart attack, or while the patient is undergoing a procedure to treat a blocked coronary artery. It is a non-peptide reversible antagonist of the platelet glycoprotein (GP) IIb/IIIa receptor, and inhibits platelet aggregation. | Major | 2 | [
[
[
20,
25,
1226
]
],
[
[
20,
23,
539
],
[
539,
62,
1226
]
],
[
[
20,
24,
714
],
[
714,
63,
1226
]
],
[
[
20,
24,
940
],
[
940,
24,
... | [
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tirofiban"
]
],
[
[
"Tenecteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsicum",
... | Tenecteplase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Tirofiban
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may ... |
DB00374 | DB00770 | 1,061 | 642 | [
"DDInter1852",
"DDInter55"
] | Treprostinil | Alprostadil | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Alprostadil is a chemically-identical synthetic form of prostaglandin E1 (PGE1), a potent vasodilator produced endogenously. In 1996, the FDA approved the use of alprostadil, administered either with an intracavernosal injection or an intraurethral suppository, for the treatment of erectile dysfunction, and it is used ... | Moderate | 1 | [
[
[
1061,
24,
642
]
],
[
[
1061,
1,
885
],
[
885,
63,
642
]
],
[
[
1061,
6,
1946
],
[
1946,
45,
642
]
],
[
[
1061,
21,
28766
],
[
28766,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alprostadil"
]
],
[
[
"Treprostinil",
"{u} (Compound) resembles {v} (Compound)",
"Epoprostenol"
],
[
"Epoprostenol",
"{u} may cause ... | Treprostinil (Compound) resembles Epoprostenol (Compound) and Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Alprostadil
Treprostinil (Compound) binds PTGIR (Gene) and PTGIR (Gene) is bound by Alprostadil (Compound)
Treprostinil (Compound) causes Hypotension (Side Effect) a... |
DB00476 | DB00945 | 109 | 1,479 | [
"DDInter608",
"DDInter20"
] | Duloxetine | Acetylsalicylic acid | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
109,
24,
1479
]
],
[
[
109,
21,
28931
],
[
28931,
60,
1479
]
],
[
[
109,
62,
837
],
[
837,
23,
1479
]
],
[
[
109,
23,
101
],
[
101,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Duloxetine",
"{u} (Compound) causes {v} (Side Effect)",
"Haemorrhage"
],
[
"Haemorrhage",
"{u} (Side E... | Duloxetine (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Acetylsalicylic acid (Compound)
Duloxetine may cause a minor interaction that can limit clinical effects when taken with Pantoprazole and Pantoprazole may cause a minor interaction that can limit clinical effects when take... |
DB08870 | DB08886 | 850 | 637 | [
"DDInter228",
"DDInter126"
] | Brentuximab vedotin | Asparaginase Erwinia chrysanthemi | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
850,
24,
637
]
],
[
[
850,
63,
640
],
[
640,
24,
637
]
],
[
[
850,
24,
250
],
[
250,
63,
637
]
],
[
[
850,
64,
581
],
[
581,
24,... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Acitretin and Acitretin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Brentuximab vedotin may cause a moderate interaction that could exacerbate disease... |
DB01073 | DB09498 | 1,488 | 810 | [
"DDInter745",
"DDInter1715"
] | Fludarabine | Strontium chloride Sr-89 | Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1488,
24,
810
]
],
[
[
1488,
63,
1555
],
[
1555,
24,
810
]
],
[
[
1488,
74,
1224
],
[
1224,
24,
810
]
],
[
[
1488,
24,
1060
],
[
1060,... | [
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Fludarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin... | Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Fludarabine (Compound) resembles Cytarabine (Compound) and Fludarabine may cause a moderate int... |
DB00927 | DB01599 | 1,559 | 1,232 | [
"DDInter712",
"DDInter1523"
] | Famotidine | Probucol | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993). | Moderate | 1 | [
[
[
1559,
24,
1232
]
],
[
[
1559,
62,
112
],
[
112,
23,
1232
]
],
[
[
1559,
63,
1555
],
[
1555,
24,
1232
]
],
[
[
1559,
24,
927
],
[
927,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Probucol"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Probucol
Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxali... |
DB01044 | DB14520 | 246 | 1,229 | [
"DDInter809",
"DDInter1785"
] | Gatifloxacin | Tetraferric tricitrate decahydrate | Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatiflox... | Tetraferric tricitrate decahydrate is an iron containing phosphate binder used to treat hyperphosphatemia and iron deficiency anemia in adults with chronic kidney disease. Tetraferric tricitrate decahydrate was granted FDA approval on 5 September 2014. | Moderate | 1 | [
[
[
246,
24,
1229
]
],
[
[
246,
63,
1096
],
[
1096,
23,
1229
]
],
[
[
246,
1,
1467
],
[
1467,
24,
1229
]
],
[
[
246,
40,
739
],
[
739,
... | [
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetraferric tricitrate decahydrate"
]
],
[
[
"Gatifloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Gatifloxacin may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid may cause a minor interaction that can limit clinical effects when taken with Tetraferric tricitrate decahydrate
Gatifloxacin (Compound) resembles Enoxacin (Compound) and Enoxacin may cau... |
DB00524 | DB00992 | 811 | 842 | [
"DDInter1199",
"DDInter1182"
] | Metolazone | Methyl aminolevulinate (topical) | A quinazoline-sulfonamide that is considered a thiazide-like diuretic which is long-acting so useful in chronic renal failure. It also tends to lower blood pressure and increase potassium loss. | Methyl 5-aminolevulinate is the methyl ester of 5-aminolevulinic acid. A prodrug, it is metabolised to protoporphyrin IX, a photosensitizer, and is used in the photodynamic treatment of non-melanoma skin cancer (including basal cell carcinoma). Topical application (often as the hydrochloride salt) results in an accumul... | Moderate | 1 | [
[
[
811,
24,
842
]
],
[
[
811,
21,
28974
],
[
28974,
60,
842
]
],
[
[
811,
24,
1274
],
[
1274,
24,
842
]
],
[
[
811,
24,
820
],
[
820,
... | [
[
[
"Metolazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methyl aminolevulinate"
]
],
[
[
"Metolazone",
"{u} (Compound) causes {v} (Side Effect)",
"Swelling"
],
[
"Swelling",
"{u} (Side Effec... | Metolazone may cause a moderate interaction that could exacerbate diseases when taken with Methyl aminolevulinate
Metolazone (Compound) causes Swelling (Side Effect) and Swelling (Side Effect) is caused by Methyl aminolevulinate (Compound)
Metolazone may cause a moderate interaction that could exacerbate diseases when ... |
DB01080 | DB06282 | 855 | 516 | [
"DDInter1933",
"DDInter1053"
] | Vigabatrin | Levocetirizine | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
855,
24,
516
]
],
[
[
855,
63,
701
],
[
701,
24,
516
]
],
[
[
855,
24,
407
],
[
407,
63,
516
]
],
[
[
855,
24,
1688
],
[
1688,
2... | [
[
[
"Vigabatrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Vigabatrin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Vigabatrin may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium m... |
DB00981 | DB01381 | 1,528 | 958 | [
"DDInter1462",
"DDInter819"
] | Physostigmine | Ginkgo biloba | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | _Ginkgo biloba_ extract contains a group of terpene lactones (notably, ginkgolides and diterpenes) and ginkgo flavone glycosides (notably, ginkgetin, bilobetin, and sciadopitysin) that have antioxidant and vasoactive properties. Most of the studies that investigate the effect of _ginkgo biloba_ use the standardized ext... | Moderate | 1 | [
[
[
1528,
24,
958
]
],
[
[
1528,
25,
593
],
[
593,
24,
958
]
],
[
[
1528,
24,
401
],
[
401,
24,
958
]
],
[
[
1528,
63,
1503
],
[
1503,
... | [
[
[
"Physostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ginkgo biloba"
]
],
[
[
"Physostigmine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
],
[
"Bu... | Physostigmine may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Ginkgo biloba
Physostigmine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine... |
DB00405 | DB00434 | 128 | 13 | [
"DDInter517",
"DDInter459"
] | Dexbrompheniramine | Cyproheptadine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
128,
24,
13
]
],
[
[
128,
24,
104
],
[
104,
63,
13
]
],
[
[
128,
63,
1302
],
[
1302,
24,
13
]
],
[
[
128,
6,
10104
],
[
10104,
4... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdil... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00022 | DB08903 | 268 | 996 | [
"DDInter1408",
"DDInter170"
] | Peginterferon alfa-2b | Bedaquiline | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Moderate | 1 | [
[
[
268,
24,
996
]
],
[
[
268,
24,
112
],
[
112,
23,
996
]
],
[
[
268,
24,
713
],
[
713,
63,
996
]
],
[
[
268,
25,
593
],
[
593,
24,... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bedaquiline"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metr... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bedaquiline
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken... |
DB01268 | DB01403 | 1,151 | 9 | [
"DDInter1731",
"DDInter1175"
] | Sunitinib | Methotrimeprazine | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1151,
24,
9
]
],
[
[
1151,
63,
1178
],
[
1178,
40,
9
]
],
[
[
1151,
63,
1164
],
[
1164,
1,
9
]
],
[
[
1151,
64,
684
],
[
684,
40... | [
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Met... |
DB00924 | DB01362 | 1,405 | 497 | [
"DDInter454",
"DDInter960"
] | Cyclobenzaprine | Iohexol | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
1405,
25,
497
]
],
[
[
1405,
21,
28681
],
[
28681,
60,
497
]
],
[
[
1405,
63,
999
],
[
999,
25,
497
]
],
[
[
1405,
25,
1264
],
[
1264,... | [
[
[
"Cyclobenzaprine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Cyclobenzaprine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Effect) i... | Cyclobenzaprine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Iohexol (Compound)
Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when ... |
DB00307 | DB06228 | 1,101 | 792 | [
"DDInter202",
"DDInter1609"
] | Bexarotene | Rivaroxaban | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Moderate | 1 | [
[
[
1101,
24,
792
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
792
]
],
[
[
1101,
21,
28703
],
[
28703,
60,
792
]
],
[
[
1101,
24,
307
],
[
307,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rivaroxaban"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rivaroxaban (Compound)
Bexarotene (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Rivaroxaban (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Modafinil and Modaf... |
DB00777 | DB09481 | 146 | 460 | [
"DDInter1537",
"DDInter1113"
] | Propiomazine | Magnesium carbonate | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Minor | 0 | [
[
[
146,
23,
460
]
],
[
[
146,
24,
401
],
[
401,
23,
460
]
],
[
[
146,
40,
216
],
[
216,
23,
460
]
],
[
[
146,
1,
104
],
[
104,
23,
... | [
[
[
"Propiomazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Propiomazine (Compound) resembles Chlorpromazine (Compound) and Chlorpromazine may cause a minor in... |
DB01299 | DB09293 | 698 | 116 | [
"DDInter1722",
"DDInter954"
] | Sulfadoxine | Iodide I-131 | A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
698,
24,
116
]
],
[
[
698,
1,
1247
],
[
1247,
24,
116
]
],
[
[
698,
64,
126
],
[
126,
24,
116
]
],
[
[
698,
63,
929
],
[
929,
24... | [
[
[
"Sulfadoxine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Sulfadoxine",
"{u} (Compound) resembles {v} (Compound)",
"Sulfamethoxazole"
],
[
"Sulfamethoxazole",
"{u} may... | Sulfadoxine (Compound) resembles Sulfamethoxazole (Compound) and Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Sulfadoxine may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a moderate interaction that could ex... |
DB00978 | DB08899 | 739 | 129 | [
"DDInter1084",
"DDInter649"
] | Lomefloxacin | Enzalutamide | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
739,
24,
129
]
],
[
[
739,
24,
918
],
[
918,
1,
129
]
],
[
[
739,
21,
28703
],
[
28703,
60,
129
]
],
[
[
739,
62,
112
],
[
112,
... | [
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Lomefloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
... | Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Lomefloxacin (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Lomefloxacin may cause a minor int... |
DB00008 | DB00951 | 491 | 1,072 | [
"DDInter1407",
"DDInter986"
] | Peginterferon alfa-2a | Isoniazid | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Moderate | 1 | [
[
[
491,
24,
1072
]
],
[
[
491,
24,
1031
],
[
1031,
24,
1072
]
],
[
[
491,
24,
309
],
[
309,
63,
1072
]
],
[
[
491,
63,
1057
],
[
1057,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoniazid"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Theoph... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Isoniazid
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken w... |
DB00641 | DB01406 | 467 | 984 | [
"DDInter1675",
"DDInter472"
] | Simvastatin | Danazol | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders. | Major | 2 | [
[
[
467,
25,
984
]
],
[
[
467,
18,
7095
],
[
7095,
45,
984
]
],
[
[
467,
6,
8374
],
[
8374,
45,
984
]
],
[
[
467,
7,
5178
],
[
5178,
... | [
[
[
"Simvastatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Danazol"
]
],
[
[
"Simvastatin",
"{u} (Compound) downregulates {v} (Gene)",
"CCL2"
],
[
"CCL2",
"{u} (Gene) is bound by {v} (Compound)",
"Dana... | Simvastatin (Compound) downregulates CCL2 (Gene) and CCL2 (Gene) is bound by Danazol (Compound)
Simvastatin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Danazol (Compound)
Simvastatin (Compound) upregulates XBP1 (Gene) and XBP1 (Gene) is upregulated by Danazol (Compound)
Simvastatin (Compound) downregul... |
DB12161 | DB14568 | 730 | 982 | [
"DDInter512",
"DDInter1000"
] | Deutetrabenazine | Ivosidenib | Deutetrabenazine is a novel, highly selective vesicular monoamine transporter 2 (VMAT2) inhibitor indicated for the management of chorea associated with Huntington’s disease. It is a hexahydro-dimethoxybenzoquinolizine derivative and a deuterated. The presence of deuterium in deutetrabenazine increases the half-lives o... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
730,
25,
982
]
],
[
[
730,
62,
112
],
[
112,
23,
982
]
],
[
[
730,
63,
543
],
[
543,
24,
982
]
],
[
[
730,
64,
11
],
[
11,
25,
... | [
[
[
"Deutetrabenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Deutetrabenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Deutetrabenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Deutetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Loperam... |
DB00543 | DB00719 | 87 | 1,219 | [
"DDInter82",
"DDInter149"
] | Amoxapine | Azatadine | Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, am... | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
87,
24,
1219
]
],
[
[
87,
63,
13
],
[
13,
24,
1219
]
],
[
[
87,
24,
830
],
[
830,
1,
1219
]
],
[
[
87,
1,
695
],
[
695,
24,
... | [
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Amoxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
[
... | Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Amoxapine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine and... |
DB00812 | DB08881 | 998 | 868 | [
"DDInter1451",
"DDInter1925"
] | Phenylbutazone | Vemurafenib | A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit conside... | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Moderate | 1 | [
[
[
998,
24,
868
]
],
[
[
998,
6,
8374
],
[
8374,
45,
868
]
],
[
[
998,
7,
7273
],
[
7273,
46,
868
]
],
[
[
998,
62,
608
],
[
608,
2... | [
[
[
"Phenylbutazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
]
],
[
[
"Phenylbutazone",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Co... | Phenylbutazone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vemurafenib (Compound)
Phenylbutazone (Compound) upregulates GPATCH8 (Gene) and GPATCH8 (Gene) is upregulated by Vemurafenib (Compound)
Phenylbutazone may cause a minor interaction that can limit clinical effects when taken with Lidocaine and L... |
DB00361 | DB00559 | 134 | 152 | [
"DDInter1939",
"DDInter223"
] | Vinorelbine | Bosentan | Vinorelbine is an anti-mitotic chemotherapy drug that is used in the treatment of several types of malignancies, including breast cancer and non-small cell lung cancer (NSCLC). It was initially approved in the USA in 1990's for the treatment of NSCLC. It is a third-generation vinca alkaloid. The introduction of third-g... | Bosentan is a dual endothelin receptor antagonist marketed under the trade name Tracleer by Actelion Pharmaceuticals. Bosentan is used to treat pulmonary hypertension by blocking the action of endothelin molecules that would otherwise promote narrowing of the blood vessels and lead to high blood pressure. | Moderate | 1 | [
[
[
134,
24,
152
]
],
[
[
134,
6,
8374
],
[
8374,
45,
152
]
],
[
[
134,
18,
5795
],
[
5795,
57,
152
]
],
[
[
134,
21,
29402
],
[
29402,
... | [
[
[
"Vinorelbine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosentan"
]
],
[
[
"Vinorelbine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Vinorelbine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosentan (Compound)
Vinorelbine (Compound) downregulates PSMB8 (Gene) and PSMB8 (Gene) is downregulated by Bosentan (Compound)
Vinorelbine (Compound) causes Hepatobiliary disease (Side Effect) and Hepatobiliary disease (Side Effect) is caused by B... |
DB09079 | DB12095 | 1,496 | 179 | [
"DDInter1296",
"DDInter1760"
] | Nintedanib | Telotristat ethyl | Nintedanib is a small molecule kinase inhibitor used in the treatment of pulmonary fibrosis, systemic sclerosis-associated interstitial lung disease, and non-small cell lung cancer (NSCLC).[L8453,L8459] It was first approved for use in the United States in 2014. Within the spectrum of idiopathic pulmonary fibrosis trea... | Telotristat ethyl is a prodrug of telotristat that was approved by the FDA in March 2017 as Xermelo. It was previously referred to as telotristat etiprate, the hippurate salt form; however, the FDA recommends the use of the name of the neutral form rather than that of the salt.[A252937, A252942] Currently, telotristat ... | Moderate | 1 | [
[
[
1496,
24,
179
]
],
[
[
1496,
24,
214
],
[
214,
24,
179
]
],
[
[
1496,
63,
1593
],
[
1593,
24,
179
]
],
[
[
1496,
24,
283
],
[
283,
... | [
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Telotristat ethyl"
]
],
[
[
"Nintedanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],... | Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Telotristat ethyl
Nintedanib may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib... |
DB06228 | DB09048 | 792 | 555 | [
"DDInter1609",
"DDInter1284"
] | Rivaroxaban | Netupitant | Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary. However there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be t... | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Moderate | 1 | [
[
[
792,
24,
555
]
],
[
[
792,
63,
1101
],
[
1101,
23,
555
]
],
[
[
792,
24,
466
],
[
466,
62,
555
]
],
[
[
792,
25,
283
],
[
283,
6... | [
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Netupitant"
]
],
[
[
"Rivaroxaban",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
... | Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Netupitant
Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Daro... |
DB00060 | DB01017 | 912 | 1,669 | [
"DDInter947",
"DDInter1224"
] | Interferon beta-1a | Minocycline | Human interferon beta (166 residues), glycosylated, MW=22.5kD. It is produced by mammalian cells (Chinese Hamster Ovary cells) into which the human interferon beta gene has been introduced. The amino acid sequence is identical to that of natural human interferon beta. | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Moderate | 1 | [
[
[
912,
24,
1669
]
],
[
[
912,
24,
45
],
[
45,
23,
1669
]
],
[
[
912,
24,
663
],
[
663,
24,
1669
]
],
[
[
912,
24,
279
],
[
279,
63... | [
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Minocycline"
]
],
[
[
"Interferon beta-1a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Didanosine... | Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Didanosine and Didanosine may cause a minor interaction that can limit clinical effects when taken with Minocycline
Interferon beta-1a may cause a moderate interaction that could exacerbate diseases when taken with Methot... |
DB08889 | DB11988 | 350 | 270 | [
"DDInter299",
"DDInter1321"
] | Carfilzomib | Ocrelizumab | Carfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combi... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
350,
24,
270
]
],
[
[
350,
63,
1461
],
[
1461,
23,
270
]
],
[
[
350,
24,
1060
],
[
1060,
63,
270
]
],
[
[
350,
63,
134
],
[
134,
... | [
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Carfilzomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin and... |
DB00087 | DB01168 | 599 | 1,053 | [
"DDInter41",
"DDInter1526"
] | Alemtuzumab | Procarbazine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
599,
24,
1053
]
],
[
[
599,
24,
848
],
[
848,
40,
1053
]
],
[
[
599,
24,
496
],
[
496,
63,
1053
]
],
[
[
599,
63,
1648
],
[
1648,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ibuprofen"
],
[... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen (Compound) resembles Procarbazine (Compound)
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Hepatitis A Vaccine and Hepatitis A Vaccine may cause a moderate in... |
DB08880 | DB08916 | 1,510 | 26 | [
"DDInter1771",
"DDInter32"
] | Teriflunomide | Afatinib | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Major | 2 | [
[
[
1510,
25,
26
]
],
[
[
1510,
64,
883
],
[
883,
40,
26
]
],
[
[
1510,
64,
651
],
[
651,
24,
26
]
],
[
[
1510,
25,
996
],
[
996,
24... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Afatinib"
]
],
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gefitinib"
],
[
"Gefitinib",
"{u}... | Teriflunomide may lead to a major life threatening interaction when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Teriflunomide may lead to a major life threatening interaction when taken with Fosphenytoin and Fosphenytoin may cause a moderate interaction that could exacerbate diseases whe... |
DB01174 | DB08882 | 697 | 1,281 | [
"DDInter1442",
"DDInter1070"
] | Phenobarbital | Linagliptin | A barbituric acid derivative that acts as a nonselective central nervous system depressant. It promotes binding to inhibitory gamma-aminobutyric acid subtype receptors, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
697,
24,
1281
]
],
[
[
697,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
697,
21,
29081
],
[
29081,
60,
1281
]
],
[
[
697,
63,
251
],
[
251,
... | [
[
[
"Phenobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Phenobarbital",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Comp... | Phenobarbital (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Phenobarbital (Compound) causes Angioedema (Side Effect) and Angioedema (Side Effect) is caused by Linagliptin (Compound)
Phenobarbital may cause a moderate interaction that could exacerbate diseases when taken with Betame... |
DB00912 | DB01118 | 473 | 33 | [
"DDInter1581",
"DDInter76"
] | Repaglinide | Amiodarone | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
473,
24,
33
]
],
[
[
473,
24,
540
],
[
540,
1,
33
]
],
[
[
473,
6,
3486
],
[
3486,
45,
33
]
],
[
[
473,
21,
28681
],
[
28681,
60... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
[... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Repaglinide (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Amiodarone (Compound)
Repaglinide (Compound) causes Hypersensitivity (Side Effect) a... |
DB00618 | DB01324 | 1,572 | 178 | [
"DDInter498",
"DDInter1490"
] | Demeclocycline | Polythiazide | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Minor | 0 | [
[
[
1572,
23,
178
]
],
[
[
1572,
23,
674
],
[
674,
40,
178
]
],
[
[
1572,
62,
1014
],
[
1014,
40,
178
]
],
[
[
1572,
40,
964
],
[
964,
... | [
[
[
"Demeclocycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Polythiazide"
]
],
[
[
"Demeclocycline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trichlormethiazide"
... | Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Trichlormethiazide and Trichlormethiazide (Compound) resembles Polythiazide (Compound)
Demeclocycline may cause a minor interaction that can limit clinical effects when taken with Benzthiazide and Benzthiazide (Compound) resemb... |
DB00647 | DB01087 | 675 | 1,520 | [
"DDInter528",
"DDInter1520"
] | Dextropropoxyphene | Primaquine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Moderate | 1 | [
[
[
675,
24,
1520
]
],
[
[
675,
25,
1487
],
[
1487,
64,
1520
]
],
[
[
675,
6,
12523
],
[
12523,
45,
1520
]
],
[
[
675,
21,
28722
],
[
2872... | [
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
]
],
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
],... | Dextropropoxyphene may lead to a major life threatening interaction when taken with Hydroxychloroquine and Hydroxychloroquine may lead to a major life threatening interaction when taken with Primaquine
Dextropropoxyphene (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Primaquine (Compound)
Dextropropoxyphe... |
DB01142 | DB01618 | 1,264 | 776 | [
"DDInter593",
"DDInter1239"
] | Doxepin | Molindone | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to mo... | Moderate | 1 | [
[
[
1264,
24,
776
]
],
[
[
1264,
6,
2250
],
[
2250,
45,
776
]
],
[
[
1264,
7,
6952
],
[
6952,
46,
776
]
],
[
[
1264,
21,
28800
],
[
28800,... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Molindone"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"DRD2"
],
[
"DRD2",
"{u} (Gene) is bound by {v} (Compound)",
"Mol... | Doxepin (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Molindone (Compound)
Doxepin (Compound) upregulates MCOLN1 (Gene) and MCOLN1 (Gene) is upregulated by Molindone (Compound)
Doxepin (Compound) causes Dyskinesia (Side Effect) and Dyskinesia (Side Effect) is caused by Molindone (Compound)
Doxepin may cause ... |
DB01268 | DB08899 | 1,151 | 129 | [
"DDInter1731",
"DDInter649"
] | Sunitinib | Enzalutamide | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
1151,
25,
129
]
],
[
[
1151,
63,
918
],
[
918,
1,
129
]
],
[
[
1151,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1151,
21,
29377
],
[
29377,
... | [
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
],
[
"Bicaluta... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Sunitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Sunitinib (Compound) causes Musculoskeletal pain (Side Effec... |
DB01261 | DB09100 | 170 | 320 | [
"DDInter1679",
"DDInter1799"
] | Sitagliptin | Thyroid, porcine | Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256]. The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improv... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
170,
24,
320
]
],
[
[
170,
63,
417
],
[
417,
23,
320
]
],
[
[
170,
63,
1144
],
[
1144,
24,
320
]
],
[
[
170,
24,
1296
],
[
1296,
... | [
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Sitagliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
],
... | Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Sitagliptin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and... |
DB00673 | DB00794 | 723 | 759 | [
"DDInter112",
"DDInter1521"
] | Aprepitant | Primidone | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Primidone is an anticonvulsant used to treat essential tremor as well as grand mal, psychomotor, and focal epileptic seizures. Primidone was developed by J Yule Bogue and H C Carrington in 1949. Primidone was granted FDA Approval on 8 March 1954. | Moderate | 1 | [
[
[
723,
24,
759
]
],
[
[
723,
24,
697
],
[
697,
40,
759
]
],
[
[
723,
63,
362
],
[
362,
1,
759
]
],
[
[
723,
6,
6017
],
[
6017,
45,... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primidone"
]
],
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenobarbital"
],
[
... | Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Phenobarbital and Phenobarbital (Compound) resembles Primidone (Compound)
Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin (Compound) resembles Primidone (Compound... |
DB00738 | DB12332 | 485 | 1,619 | [
"DDInter1420",
"DDInter1626"
] | Pentamidine | Rucaparib | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Rucaparib is an anticancer drug and poly (ADP-ribose) polymerase (PARP) inhibitor. PARP is an enzyme that plays an essential role in DNA repair. Rucaparib is proposed to work in several PARP-dependent and PARP-independent mechanisms of action; however, it causes a unique effect of synthetic lethality. By targeting the ... | Moderate | 1 | [
[
[
485,
24,
1619
]
],
[
[
485,
23,
112
],
[
112,
23,
1619
]
],
[
[
485,
63,
87
],
[
87,
24,
1619
]
],
[
[
485,
24,
1662
],
[
1662,
... | [
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
]
],
[
[
"Pentamidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Pentamidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Rucaparib
Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Amoxapine and Amox... |
DB01591 | DB09078 | 667 | 1,228 | [
"DDInter1696",
"DDInter1036"
] | Solifenacin | Lenvatinib | Solifenacin is a competitive muscarinic receptor antagonist indicated to treat an overactive bladder with urinary incontinence, urgency, and frequency. It has a long duration of action as it is usually taken once daily. Solifenacin was granted FDA approval on 19 November 2004. | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
667,
24,
1228
]
],
[
[
667,
62,
112
],
[
112,
23,
1228
]
],
[
[
667,
64,
609
],
[
609,
24,
1228
]
],
[
[
667,
63,
1264
],
[
1264,
... | [
[
[
"Solifenacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Solifenacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Solifenacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Solifenacin may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromyci... |
DB00495 | DB00552 | 139 | 1,238 | [
"DDInter1961",
"DDInter1425"
] | Zidovudine | Pentostatin | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
139,
24,
1238
]
],
[
[
139,
63,
1083
],
[
1083,
40,
1238
]
],
[
[
139,
24,
1426
],
[
1426,
1,
1238
]
],
[
[
139,
1,
1477
],
[
1477,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
],
[... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine (Compound) resembles Pentostatin (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Pentostatin (Co... |
DB00539 | DB00776 | 11 | 1,335 | [
"DDInter1837",
"DDInter1360"
] | Toremifene | Oxcarbazepine | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Moderate | 1 | [
[
[
11,
24,
1335
]
],
[
[
11,
24,
1605
],
[
1605,
1,
1335
]
],
[
[
11,
25,
1264
],
[
1264,
63,
1335
]
],
[
[
11,
25,
1236
],
[
1236,
... | [
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxcarbazepine"
]
],
[
[
"Toremifene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Indapamide"
],
[... | Toremifene may cause a moderate interaction that could exacerbate diseases when taken with Indapamide and Indapamide (Compound) resembles Oxcarbazepine (Compound)
Toremifene may lead to a major life threatening interaction when taken with Doxepin and Doxepin may cause a moderate interaction that could exacerbate diseas... |
DB00978 | DB11730 | 739 | 351 | [
"DDInter1084",
"DDInter1588"
] | Lomefloxacin | Ribociclib | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
739,
25,
351
]
],
[
[
739,
62,
112
],
[
112,
23,
351
]
],
[
[
739,
63,
355
],
[
355,
24,
351
]
],
[
[
739,
23,
1532
],
[
1532,
2... | [
[
[
"Lomefloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Lomefloxacin may cause a moderate interaction that could exacerbate diseases when taken with Lactulose and L... |
DB09293 | DB11166 | 116 | 18 | [
"DDInter954",
"DDInter104"
] | Iodide I-131 | Antithrombin Alfa | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations. | Moderate | 1 | [
[
[
116,
24,
18
]
],
[
[
116,
63,
1409
],
[
1409,
25,
18
]
],
[
[
116,
24,
1421
],
[
1421,
64,
18
]
],
[
[
116,
63,
1409
],
[
1409,
... | [
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Antithrombin Alfa"
]
],
[
[
"Iodide I-131",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
],... | Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and Apixaban may lead to a major life threatening interaction when taken with Antithrombin Alfa
Iodide I-131 may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban and Betrixaban may... |
DB08880 | DB11988 | 1,510 | 270 | [
"DDInter1771",
"DDInter1321"
] | Teriflunomide | Ocrelizumab | Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of h... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Major | 2 | [
[
[
1510,
25,
270
]
],
[
[
1510,
23,
1193
],
[
1193,
23,
270
]
],
[
[
1510,
62,
1461
],
[
1461,
23,
270
]
],
[
[
1510,
25,
1060
],
[
1060,... | [
[
[
"Teriflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Teriflunomide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
],
[
"Z... | Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when taken with Ocrelizumab
Teriflunomide may cause a minor interaction that can limit clinical effects when taken with Vitamin E an... |
DB00214 | DB08899 | 1,028 | 129 | [
"DDInter1836",
"DDInter649"
] | Torasemide | Enzalutamide | Torasemide is a high-ceiling loop diuretic. Structurally, it is a pyridine-sulfonylurea used as an antihypertensive agent. Torasemide was first approved for clinical use by the FDA in 1993. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1028,
24,
129
]
],
[
[
1028,
6,
6017
],
[
6017,
45,
129
]
],
[
[
1028,
21,
28921
],
[
28921,
60,
129
]
],
[
[
1028,
24,
112
],
[
112,
... | [
[
[
"Torasemide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Torasemide",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)... | Torasemide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Enzalutamide (Compound)
Torasemide (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Enzalutamide (Compound)
Torasemide may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole a... |
DB00652 | DB00719 | 234 | 1,219 | [
"DDInter1421",
"DDInter149"
] | Pentazocine | Azatadine | The first mixed agonist-antagonist analgesic to be marketed. It is an agonist at the kappa and sigma opioid receptors and has a weak antagonist action at the mu receptor. (From AMA Drug Evaluations Annual, 1991, p97) | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Moderate | 1 | [
[
[
234,
24,
1219
]
],
[
[
234,
63,
13
],
[
13,
24,
1219
]
],
[
[
234,
24,
830
],
[
830,
1,
1219
]
],
[
[
234,
24,
543
],
[
543,
63,... | [
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
]
],
[
[
"Pentazocine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
],
... | Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine and Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine
Pentazocine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine... |
DB00860 | DB10675 | 891 | 961 | [
"DDInter1513",
"DDInter1065"
] | Prednisolone | Licorice | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Licorice allergenic extract is used in allergenic testing. | Moderate | 1 | [
[
[
891,
24,
961
]
],
[
[
891,
40,
870
],
[
870,
24,
961
]
],
[
[
891,
24,
1231
],
[
1231,
24,
961
]
],
[
[
891,
1,
617
],
[
617,
24... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Licorice"
]
],
[
[
"Prednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Fludrocortisone"
],
[
"Fludrocortisone",
"{u} may cau... | Prednisolone (Compound) resembles Fludrocortisone (Compound) and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Licorice
Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer and Tolevamer may cause a moderate interaction ... |
DB00685 | DB08907 | 1,299 | 1,344 | [
"DDInter1887",
"DDInter280"
] | Trovafloxacin | Canagliflozin | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Moderate | 1 | [
[
[
1299,
24,
1344
]
],
[
[
1299,
24,
549
],
[
549,
1,
1344
]
],
[
[
1299,
21,
28873
],
[
28873,
60,
1344
]
],
[
[
1299,
1,
739
],
[
739,
... | [
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canagliflozin"
]
],
[
[
"Trovafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
... | Trovafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin (Compound) resembles Canagliflozin (Compound)
Trovafloxacin (Compound) causes Pancreatitis (Side Effect) and Pancreatitis (Side Effect) is caused by Canagliflozin (Compound)
Trovafloxacin (Compo... |
DB00213 | DB01172 | 837 | 416 | [
"DDInter1388",
"DDInter1004"
] | Pantoprazole | Kanamycin | Pantoprazole is a first-generation proton pump inhibitor (PPI) used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zolling... | Kanamycin (also known as kanamycin A) is an aminoglycoside bacteriocidal antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections. Kanamycin is isolated from the bacterium Streptomyces kanamyceticus and its most commonly used form is kanamycin sulfate. | Moderate | 1 | [
[
[
837,
24,
416
]
],
[
[
837,
21,
29196
],
[
29196,
60,
416
]
],
[
[
837,
24,
1252
],
[
1252,
23,
416
]
],
[
[
837,
24,
1381
],
[
1381,
... | [
[
[
"Pantoprazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Kanamycin"
]
],
[
[
"Pantoprazole",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (Side Effect... | Pantoprazole (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Kanamycin (Compound)
Pantoprazole may cause a moderate interaction that could exacerbate diseases when taken with Digoxin and Digoxin may cause a minor interaction that can limit clinical effects when taken with Kanamy... |
DB00218 | DB00888 | 1,176 | 1,001 | [
"DDInter1247",
"DDInter1133"
] | Moxifloxacin | Mechlorethamine | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | A vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. The hydrochloride is used as an antineoplastic in Hodgkin's disease and lymphomas. It causes severe gastrointestinal and bone marrow damage. The FDA granted marketing approval f... | Minor | 0 | [
[
[
1176,
23,
1001
]
],
[
[
1176,
23,
450
],
[
450,
1,
1001
]
],
[
[
1176,
21,
28725
],
[
28725,
60,
1001
]
],
[
[
1176,
25,
126
],
[
126,... | [
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mechlorethamine"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cyclophosphamide"
... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Cyclophosphamide and Cyclophosphamide (Compound) resembles Mechlorethamine (Compound)
Moxifloxacin (Compound) causes Pancytopenia (Side Effect) and Pancytopenia (Side Effect) is caused by Mechlorethamine (Compound)
Moxifloxacin m... |
DB01234 | DB08931 | 1,220 | 947 | [
"DDInter513",
"DDInter1600"
] | Dexamethasone | Riociguat | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Riociguat is a soluble guanylate cyclase (sGC) agonist approved in the USA, Europe and several other regions for patients with group I PAH (pulmonary arterial hypertension) in WHO FC II or III; and for the treatment of patients with inoperable CTEPH (chronic thromboembolic pulmonary hypertension), or persistent/recurre... | Moderate | 1 | [
[
[
1220,
24,
947
]
],
[
[
1220,
24,
1478
],
[
1478,
24,
947
]
],
[
[
1220,
63,
609
],
[
609,
24,
947
]
],
[
[
1220,
25,
124
],
[
124,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riociguat"
]
],
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
... | Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Riociguat
Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and... |
DB00286 | DB06335 | 380 | 761 | [
"DDInter439",
"DDInter1646"
] | Conjugated estrogens | Saxagliptin | The conjugated estrogens are noncrystalline mixtures of purified female sex hormones obtained either by its isolation from the urine of pregnant mares or by synthetic generation from vegetal material. Both of these products are later conjugated to natrium sulfate by ester bonds in order to make them more water soluble.... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
380,
24,
761
]
],
[
[
380,
6,
16560
],
[
16560,
45,
761
]
],
[
[
380,
21,
28966
],
[
28966,
60,
761
]
],
[
[
380,
24,
1573
],
[
1573,
... | [
[
[
"Conjugated estrogens",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Conjugated estrogens",
"{u} (Compound) binds {v} (Gene)",
"SLC22A8"
],
[
"SLC22A8",
"{u} (Gene) is bo... | Conjugated estrogens (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Saxagliptin (Compound)
Conjugated estrogens (Compound) causes Upper respiratory tract infection (Side Effect) and Upper respiratory tract infection (Side Effect) is caused by Saxagliptin (Compound)
Conjugated estrogens may cause a moder... |
DB00836 | DB08864 | 543 | 786 | [
"DDInter1088",
"DDInter1595"
] | Loperamide | Rilpivirine | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | Rilpivirine is non-nucleoside reverse transcriptase inhibitor (NNRTI) which is used for the treatment of HIV-1 infections in treatment-naive patients. It is a diarylpyrimidine derivative. The internal conformational flexibility of rilpivirine and the plasticity of it interacting binding site gives it a very high potenc... | Moderate | 1 | [
[
[
543,
24,
786
]
],
[
[
543,
6,
8374
],
[
8374,
45,
786
]
],
[
[
543,
21,
28734
],
[
28734,
60,
786
]
],
[
[
543,
24,
112
],
[
112,
... | [
[
[
"Loperamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilpivirine"
]
],
[
[
"Loperamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Loperamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Rilpivirine (Compound)
Loperamide (Compound) causes Immune system disorder (Side Effect) and Immune system disorder (Side Effect) is caused by Rilpivirine (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when ta... |
DB00470 | DB01068 | 530 | 1,565 | [
"DDInter601",
"DDInter411"
] | Dronabinol | Clonazepam | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A benzodiazepine used to treat various seizures, including myotonic or atonic seizures, photosensitive epilepsy, and absence seizures, although tolerance may develop.[FDA Label][L5572,F3763,F3787,F3796] The agent has also been indicated for treating panic disorder.[FDA Label][A175438,L5572,F3763,F3787,F3796] The mechan... | Moderate | 1 | [
[
[
530,
24,
1565
]
],
[
[
530,
24,
1382
],
[
1382,
1,
1565
]
],
[
[
530,
24,
1216
],
[
1216,
40,
1565
]
],
[
[
530,
63,
695
],
[
695,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonazepam"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Midazolam"
],
[
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Midazolam and Midazolam (Compound) resembles Clonazepam (Compound)
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Flurazepam and Flurazepam (Compound) resembles Clonazepam (Compound)
Dr... |
DB01284 | DB06288 | 1,042 | 607 | [
"DDInter1782",
"DDInter77"
] | Tetracosactide | Amisulpride | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Moderate | 1 | [
[
[
1042,
24,
607
]
],
[
[
1042,
63,
1287
],
[
1287,
24,
607
]
],
[
[
1042,
24,
28
],
[
28,
63,
607
]
],
[
[
1042,
62,
480
],
[
480,
... | [
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amisulpride"
]
],
[
[
"Tetracosactide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amphotericin B"
... | Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Amphotericin B and Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Amisulpride
Tetracosactide may cause a moderate interaction that could exacerbate diseases when taken with Bisa... |
DB00434 | DB00934 | 13 | 413 | [
"DDInter459",
"DDInter1124"
] | Cyproheptadine | Maprotiline | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
13,
24,
413
]
],
[
[
13,
63,
1302
],
[
1302,
40,
413
]
],
[
[
13,
40,
114
],
[
114,
40,
413
]
],
[
[
13,
1,
11321
],
[
11321,
40... | [
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Cyproheptadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
... | Cyproheptadine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Cyproheptadine (Compound) resembles Nortriptyline (Compound) and Nortriptyline (Compound) resembles Maprotiline (Compound)
Cyproheptadine (Compound) ... |
DB04953 | DB11186 | 495 | 1,609 | [
"DDInter708",
"DDInter1427"
] | Ezogabine | Pentoxyverine | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
495,
24,
1609
]
],
[
[
495,
63,
649
],
[
649,
24,
1609
]
],
[
[
495,
24,
849
],
[
849,
24,
1609
]
],
[
[
495,
63,
649
],
[
649,
... | [
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Ezogabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
],
[
... | Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Ezogabine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyr... |
DB00619 | DB00690 | 1,419 | 1,216 | [
"DDInter909",
"DDInter762"
] | Imatinib | Flurazepam | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | A benzodiazepine derivative used mainly as a hypnotic. | Moderate | 1 | [
[
[
1419,
24,
1216
]
],
[
[
1419,
24,
1418
],
[
1418,
1,
1216
]
],
[
[
1419,
63,
216
],
[
216,
1,
1216
]
],
[
[
1419,
63,
902
],
[
902,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurazepam"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estazolam"
],
[
"... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Estazolam and Estazolam (Compound) resembles Flurazepam (Compound)
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Chlorpromazine and Chlorpromazine (Compound) resembles Flurazepam (Compound... |
DB00039 | DB11730 | 1,253 | 351 | [
"DDInter1380",
"DDInter1588"
] | Palifermin | Ribociclib | Palifermin is a recombinant human keratinocyte growth factor (KGF). It is 140 residues long, and is produced using E. coli. Palifermin was granted FDA approval on 15 December 2004. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
1253,
24,
351
]
],
[
[
1253,
24,
310
],
[
310,
24,
351
]
],
[
[
1253,
24,
738
],
[
738,
63,
351
]
],
[
[
1253,
24,
975
],
[
975,
... | [
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Palifermin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
... | Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib
Palifermin may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Nirap... |
DB01023 | DB01164 | 409 | 803 | [
"DDInter716",
"DDInter272"
] | Felodipine | Calcium chloride | Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte... | Calcium chloride is an ionic compound of calcium and chlorine. It is highly soluble in water and it is deliquescent. It is a salt that is solid at room temperature, and it behaves as a typical ionic halide. It has several common applications such as brine for refrigeration plants, ice and dust control on roads, and in ... | Moderate | 1 | [
[
[
409,
24,
803
]
],
[
[
409,
21,
29196
],
[
29196,
60,
803
]
],
[
[
409,
40,
84
],
[
84,
24,
803
]
],
[
[
409,
1,
1081
],
[
1081,
... | [
[
[
"Felodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium chloride"
]
],
[
[
"Felodipine",
"{u} (Compound) causes {v} (Side Effect)",
"Paraesthesia"
],
[
"Paraesthesia",
"{u} (Side Eff... | Felodipine (Compound) causes Paraesthesia (Side Effect) and Paraesthesia (Side Effect) is caused by Calcium chloride (Compound)
Felodipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Calcium chloride
Felodipine (Compound) re... |
DB01097 | DB06718 | 1,377 | 1,687 | [
"DDInter1033",
"DDInter1709"
] | Leflunomide | Stanozolol | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Major | 2 | [
[
[
1377,
25,
1687
]
],
[
[
1377,
25,
1546
],
[
1546,
1,
1687
]
],
[
[
1377,
64,
1561
],
[
1561,
40,
1687
]
],
[
[
1377,
25,
984
],
[
984,... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Stanozolol"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methyltestosterone"
],
[
"Methyltestoster... | Leflunomide may lead to a major life threatening interaction when taken with Methyltestosterone and Methyltestosterone (Compound) resembles Stanozolol (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Testosterone and Testosterone (Compound) resembles Stanozolol (Compound)
Leflunom... |
DB01324 | DB11057 | 178 | 720 | [
"DDInter1490",
"DDInter1223"
] | Polythiazide | Mineral oil | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Mineral oil, or paraffin oil, is a mixture of higher alkanes from a mineral source, such as petroleum. Petroleum mineral oil is manufactured from crude oils by vacuum distillation to produce several distillates and a residual oil that are then further refined. During the modern refining process, aromatics are reduced b... | Moderate | 1 | [
[
[
178,
24,
720
]
],
[
[
178,
63,
175
],
[
175,
24,
720
]
],
[
[
178,
1,
323
],
[
323,
24,
720
]
],
[
[
178,
64,
1425
],
[
1425,
24... | [
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mineral oil"
]
],
[
[
"Polythiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
],
... | Polythiazide may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone may cause a moderate interaction that could exacerbate diseases when taken with Mineral oil
Polythiazide (Compound) resembles Bendroflumethiazide (Compound) and Bendroflumethiazide may cause a mo... |
DB00283 | DB00771 | 701 | 262 | [
"DDInter395",
"DDInter397"
] | Clemastine | Clidinium | An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness. | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Moderate | 1 | [
[
[
701,
24,
262
]
],
[
[
701,
35,
1511
],
[
1511,
63,
262
]
],
[
[
701,
24,
543
],
[
543,
63,
262
]
],
[
[
701,
24,
19
],
[
19,
24,... | [
[
[
"Clemastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clidinium"
]
],
[
[
"Clemastine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken wi... | Clemastine (Compound) resembles Mepenzolate (Compound) and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Clidinium
Clemastine may cause a moderate interaction that cou... |
DB00501 | DB01192 | 752 | 560 | [
"DDInter380",
"DDInter1372"
] | Cimetidine | Oxymorphone | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | An opioid analgesic with actions and uses similar to those of morphine, apart from an absence of cough suppressant activity. It is used in the treatment of moderate to severe pain, including pain in obstetrics. It may also be used as an adjunct to anesthesia (From Martindale, The Extra Pharmacopoeia, 30th ed, p1092). O... | Moderate | 1 | [
[
[
752,
24,
560
]
],
[
[
752,
64,
828
],
[
828,
1,
560
]
],
[
[
752,
24,
314
],
[
314,
1,
560
]
],
[
[
752,
63,
421
],
[
421,
1,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxymorphone"
]
],
[
[
"Cimetidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oxycodone"
],
[
"Oxycodone"... | Cimetidine may lead to a major life threatening interaction when taken with Oxycodone and Oxycodone (Compound) resembles Oxymorphone (Compound)
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Nalbuphine and Nalbuphine (Compound) resembles Oxymorphone (Compound)
Cimetidine may ... |
DB00455 | DB05381 | 1,601 | 172 | [
"DDInter1091",
"DDInter863"
] | Loratadine | Histamine | Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. A lack of sedative and CNS adverse effects make loratadine, along with other second generation antihistamines, preferable over their 1st generation counterparts in many clinical situations. | A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. | Moderate | 1 | [
[
[
1601,
24,
172
]
],
[
[
1601,
24,
851
],
[
851,
24,
172
]
],
[
[
1601,
40,
1219
],
[
1219,
24,
172
]
],
[
[
1601,
24,
851
],
[
851,
... | [
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histamine"
]
],
[
[
"Loratadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],
[
... | Loratadine may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone may cause a moderate interaction that could exacerbate diseases when taken with Histamine
Loratadine (Compound) resembles Azatadine (Compound) and Azatadine may cause a moderate interaction that could ex... |
DB04868 | DB06788 | 478 | 1,616 | [
"DDInter1293",
"DDInter864"
] | Nilotinib | Histrelin | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
478,
25,
1616
]
],
[
[
478,
62,
112
],
[
112,
23,
1616
]
],
[
[
478,
64,
1664
],
[
1664,
24,
1616
]
],
[
[
478,
25,
1342
],
[
1342,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Nilotinib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazol... | Nilotinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Nilotinib may lead to a major life threatening interaction when taken with Risperidone and Risperidone may cause... |
DB00529 | DB00539 | 789 | 11 | [
"DDInter779",
"DDInter1837"
] | Foscarnet | Toremifene | An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpes viruses and HIV. | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Major | 2 | [
[
[
789,
25,
11
]
],
[
[
789,
21,
28936
],
[
28936,
60,
11
]
],
[
[
789,
23,
112
],
[
112,
62,
11
]
],
[
[
789,
24,
144
],
[
144,
63... | [
[
[
"Foscarnet",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Toremifene"
]
],
[
[
"Foscarnet",
"{u} (Compound) causes {v} (Side Effect)",
"Hyperhidrosis"
],
[
"Hyperhidrosis",
"{u} (Side Effect) is caused by {v}... | Foscarnet (Compound) causes Hyperhidrosis (Side Effect) and Hyperhidrosis (Side Effect) is caused by Toremifene (Compound)
Foscarnet may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with... |
DB01357 | DB06176 | 890 | 1,342 | [
"DDInter1160",
"DDInter1616"
] | Mestranol | Romidepsin | The 3-methyl ether of ethinyl estradiol. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL contraceptives. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Moderate | 1 | [
[
[
890,
24,
1342
]
],
[
[
890,
63,
112
],
[
112,
23,
1342
]
],
[
[
890,
24,
1033
],
[
1033,
63,
1342
]
],
[
[
890,
63,
58
],
[
58,
... | [
[
[
"Mestranol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Romidepsin"
]
],
[
[
"Mestranol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Mestranol may cause a moderate interaction that could exacerbate diseases when taken with Alpelisib and Alpel... |
DB00820 | DB11718 | 402 | 927 | [
"DDInter1736",
"DDInter640"
] | Tadalafil | Encorafenib | Tadalafil is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy.[L39100, L39105] It was first approved in 2003 by the FDA for use in ED and later in 2009 for PAH. In contrast to other PDE5 inhibito... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
402,
24,
927
]
],
[
[
402,
63,
1324
],
[
1324,
24,
927
]
],
[
[
402,
24,
1478
],
[
1478,
24,
927
]
],
[
[
402,
24,
1320
],
[
1320,
... | [
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Tadalafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Troglitazone"
],
[
... | Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Troglitazone and Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Tadalafil may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivac... |
DB01050 | DB08899 | 848 | 129 | [
"DDInter900",
"DDInter649"
] | Ibuprofen | Enzalutamide | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
848,
24,
129
]
],
[
[
848,
6,
1829
],
[
1829,
45,
129
]
],
[
[
848,
21,
28703
],
[
28703,
60,
129
]
],
[
[
848,
63,
312
],
[
312,
... | [
[
[
"Ibuprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Ibuprofen",
"{u} (Compound) binds {v} (Gene)",
"ALB"
],
[
"ALB",
"{u} (Gene) is bound by {v} (Compound)",
... | Ibuprofen (Compound) binds ALB (Gene) and ALB (Gene) is bound by Enzalutamide (Compound)
Ibuprofen (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Ibuprofen may cause a moderate interaction that could exacerbate diseases when taken with Eplerenone and Eplerenone ... |
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