drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00704 | DB09061 | 267 | 1,627 | [
"DDInter1263",
"DDInter284"
] | Naltrexone | Cannabidiol | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
267,
24,
1627
]
],
[
[
267,
24,
609
],
[
609,
23,
1627
]
],
[
[
267,
63,
600
],
[
600,
23,
1627
]
],
[
[
267,
24,
351
],
[
351,
... | [
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole an... |
DB00599 | DB09293 | 682 | 116 | [
"DDInter1795",
"DDInter954"
] | Thiopental | Iodide I-131 | A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does no... | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
682,
24,
116
]
],
[
[
682,
63,
701
],
[
701,
24,
116
]
],
[
[
682,
24,
516
],
[
516,
24,
116
]
],
[
[
682,
25,
126
],
[
126,
24,... | [
[
[
"Thiopental",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Thiopental",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Thiopental may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine and ... |
DB00388 | DB01577 | 1,636 | 1,529 | [
"DDInter1453",
"DDInter1161"
] | Phenylephrine | Metamfetamine | Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s. Phenylephrine was granted FDA approval in 1939. | Metamfetamine (methamphetamine) is a psychostimulant and sympathomimetic drug, and a member of the amphetamine group of sympathomimetic amines. Methamphetamine can induce effects such as euphoria, increased alertness and energy, and enhanced self-esteem. It is a scheduled drug in most countries due to its high potentia... | Moderate | 1 | [
[
[
1636,
24,
1529
]
],
[
[
1636,
24,
939
],
[
939,
40,
1529
]
],
[
[
1636,
25,
1161
],
[
1161,
40,
1529
]
],
[
[
1636,
63,
80
],
[
80,
... | [
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metamfetamine"
]
],
[
[
"Phenylephrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzphetamine"
... | Phenylephrine may cause a moderate interaction that could exacerbate diseases when taken with Benzphetamine and Benzphetamine (Compound) resembles Metamfetamine (Compound)
Phenylephrine may lead to a major life threatening interaction when taken with Selegiline and Selegiline (Compound) resembles Metamfetamine (Compoun... |
DB00352 | DB11817 | 482 | 1,259 | [
"DDInter1814",
"DDInter165"
] | Tioguanine | Baricitinib | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
482,
25,
1259
]
],
[
[
482,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
482,
24,
1274
],
[
1274,
24,
1259
]
],
[
[
482,
63,
831
],
[
831,
... | [
[
[
"Tioguanine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin E"... | Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbip... |
DB00562 | DB01285 | 1,014 | 708 | [
"DDInter188",
"DDInter445"
] | Benzthiazide | Corticotropin | Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used... | Corticotropin (ACTH or adrenocorticotropic hormone) is a polypeptide hormone produced and secreted by the pituitary gland. It is an important player in the hypothalamic-pituitary-adrenal axis. | Moderate | 1 | [
[
[
1014,
24,
708
]
],
[
[
1014,
24,
455
],
[
455,
23,
708
]
],
[
[
1014,
24,
659
],
[
659,
62,
708
]
],
[
[
1014,
63,
245
],
[
245,
... | [
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
]
],
[
[
"Benzthiazide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
],
... | Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol and Salmeterol may cause a minor interaction that can limit clinical effects when taken with Corticotropin
Benzthiazide may cause a moderate interaction that could exacerbate diseases when taken with Vilanterol and V... |
DB01390 | DB14006 | 1,117 | 972 | [
"DDInter1683",
"DDInter370"
] | Sodium bicarbonate | Choline salicylate | Sodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions. | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1117,
24,
972
]
],
[
[
1117,
62,
1573
],
[
1573,
24,
972
]
],
[
[
1117,
63,
1411
],
[
1411,
24,
972
]
],
[
[
1117,
62,
663
],
[
663,
... | [
[
[
"Sodium bicarbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Sodium bicarbonate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Predn... | Sodium bicarbonate may cause a minor interaction that can limit clinical effects when taken with Prednisone and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Sodium bicarbonate may cause a moderate interaction that could exacerbate diseases when taken with... |
DB06688 | DB15091 | 1,430 | 676 | [
"DDInter1677",
"DDInter1901"
] | Sipuleucel-T | Upadacitinib | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
1430,
24,
676
]
],
[
[
1430,
63,
1184
],
[
1184,
25,
676
]
],
[
[
1430,
24,
503
],
[
503,
25,
676
]
],
[
[
1430,
24,
899
],
[
899,
... | [
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Sipuleucel-T",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
],
... | Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may lead to a major life threatening interaction when taken with Upadacitinib
Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib and Zanubrutinib may ... |
DB00477 | DB00889 | 216 | 1,133 | [
"DDInter363",
"DDInter840"
] | Chlorpromazine | Granisetron | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Moderate | 1 | [
[
[
216,
24,
1133
]
],
[
[
216,
63,
19
],
[
19,
40,
1133
]
],
[
[
216,
24,
85
],
[
85,
1,
1133
]
],
[
[
216,
6,
8374
],
[
8374,
45,
... | [
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Granisetron"
]
],
[
[
"Chlorpromazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
]... | Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine (Compound) resembles Granisetron (Compound)
Chlorpromazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine (Compound) resembles Granisetron (Co... |
DB00831 | DB00835 | 1,178 | 100 | [
"DDInter1866",
"DDInter245"
] | Trifluoperazine | Brompheniramine | A phenothiazine with actions similar to chlorpromazine. It is used as an antipsychotic and an antiemetic. | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
1178,
24,
100
]
],
[
[
1178,
63,
832
],
[
832,
24,
100
]
],
[
[
1178,
1,
508
],
[
508,
24,
100
]
],
[
[
1178,
24,
28
],
[
28,
40... | [
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Trifluoperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennami... | Trifluoperazine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Trifluoperazine (Compound) resembles Promazine (Compound) and Promazine may cause a moderate i... |
DB00252 | DB01132 | 362 | 1,130 | [
"DDInter1460",
"DDInter1472"
] | Phenytoin | Pioglitazone | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.[L11416,L11419,L11422,L11425] It is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert _in ... | Moderate | 1 | [
[
[
362,
24,
1130
]
],
[
[
362,
6,
6017
],
[
6017,
45,
1130
]
],
[
[
362,
21,
28778
],
[
28778,
60,
1130
]
],
[
[
362,
24,
303
],
[
303,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pioglitazone"
]
],
[
[
"Phenytoin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",... | Phenytoin (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Pioglitazone (Compound)
Phenytoin (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused by Pioglitazone (Compound)
Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00047 | DB06016 | 176 | 1,508 | [
"DDInter932",
"DDInter300"
] | Insulin glargine | Cariprazine | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary. It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT<sub>1A</sub> receptors and as an antagonist at serotonin 5-HT<sub>2A</sub> receptors. Cariprazine has been investigated in... | Moderate | 1 | [
[
[
176,
24,
1508
]
],
[
[
176,
24,
1450
],
[
1450,
63,
1508
]
],
[
[
176,
24,
245
],
[
245,
24,
1508
]
],
[
[
176,
23,
274
],
[
274,
... | [
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cariprazine"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Cariprazine
Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Gl... |
DB00405 | DB00780 | 128 | 551 | [
"DDInter517",
"DDInter1440"
] | Dexbrompheniramine | Phenelzine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Moderate | 1 | [
[
[
128,
24,
551
]
],
[
[
128,
24,
94
],
[
94,
40,
551
]
],
[
[
128,
24,
1442
],
[
1442,
23,
551
]
],
[
[
128,
24,
1192
],
[
1192,
6... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenelzine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenacemide... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Phenacemide and Phenacemide (Compound) resembles Phenelzine (Compound)
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine and Scopolamine may cause a minor inter... |
DB00333 | DB08899 | 576 | 129 | [
"DDInter1166",
"DDInter649"
] | Methadone | Enzalutamide | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Major | 2 | [
[
[
576,
25,
129
]
],
[
[
576,
25,
918
],
[
918,
1,
129
]
],
[
[
576,
6,
8374
],
[
8374,
45,
129
]
],
[
[
576,
21,
28703
],
[
28703,
... | [
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
]
],
[
[
"Methadone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
],
[
"Bicalutamide",
"{... | Methadone may lead to a major life threatening interaction when taken with Bicalutamide and Bicalutamide (Compound) resembles Enzalutamide (Compound)
Methadone (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Methadone (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effec... |
DB00106 | DB09472 | 618 | 1,383 | [
"DDInter4",
"DDInter1693"
] | Abarelix | Sodium sulfate | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
618,
24,
1383
]
],
[
[
618,
24,
609
],
[
609,
24,
1383
]
],
[
[
618,
24,
1612
],
[
1612,
63,
1383
]
],
[
[
618,
25,
607
],
[
607,
... | [
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Abarelix",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
],
... | Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Fostemsavir a... |
DB04865 | DB09331 | 4 | 745 | [
"DDInter1335",
"DDInter478"
] | Omacetaxine mepesuccinate | Daratumumab | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Daratumumab is an immunoglobulin G1 kappa monoclonal antibody developed by Janssen and Genmab. It was first described in the literature in 2010 as a monoclonal antibody that targets CD38+ multiple myeloma cells; the first of its kind. Daratumumab was granted FDA approval on 16 November 2015. It is approved for the trea... | Moderate | 1 | [
[
[
4,
24,
745
]
],
[
[
4,
63,
139
],
[
139,
24,
745
]
],
[
[
4,
24,
287
],
[
287,
63,
745
]
],
[
[
4,
24,
1362
],
[
1362,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daratumumab"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Daratumumab
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when t... |
DB08820 | DB09237 | 1,478 | 1,586 | [
"DDInter997",
"DDInter1045"
] | Ivacaftor | Levamlodipine | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Levamlodipine, also known as S-amlodipine, is a pharmacologically active enantiomer of [amlodipine], an antihypertensive medication. Levamlodipine belongs to the dihydropyridine group of calcium channel blockers. This medication was first marketed in Russia and India before being granted FDA approval. The names S-amlod... | Moderate | 1 | [
[
[
1478,
24,
1586
]
],
[
[
1478,
63,
578
],
[
578,
23,
1586
]
],
[
[
1478,
63,
870
],
[
870,
24,
1586
]
],
[
[
1478,
24,
1297
],
[
1297,
... | [
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levamlodipine"
]
],
[
[
"Ivacaftor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ticagrelor"
],
[
... | Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Levamlodipine
Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fl... |
DB05015 | DB05528 | 1,077 | 1,070 | [
"DDInter174",
"DDInter1228"
] | Belinostat | Mipomersen | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
1077,
25,
1070
]
],
[
[
1077,
24,
292
],
[
292,
64,
1070
]
],
[
[
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],
[
581,
25,
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]
],
[
[
1077,
25,
1510
],
[
1510,
... | [
[
[
"Belinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
],
[
"Regorafen... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib and Regorafenib may lead to a major life threatening interaction when taken with Mipomersen
Belinostat may lead to a major life threatening interaction when taken with Infliximab and Infliximab may lead to a major lif... |
DB00220 | DB09074 | 798 | 1,362 | [
"DDInter1276",
"DDInter1327"
] | Nelfinavir | Olaparib | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
798,
25,
1362
]
],
[
[
798,
24,
896
],
[
896,
24,
1362
]
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[
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798,
25,
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],
[
1478,
24,
1362
]
],
[
[
798,
63,
168
],
[
168,
... | [
[
[
"Nelfinavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Etoposide",
... | Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Nelfinavir may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a mode... |
DB00446 | DB00682 | 597 | 126 | [
"DDInter351",
"DDInter1951"
] | Chloramphenicol | Warfarin | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
597,
24,
126
]
],
[
[
597,
63,
362
],
[
362,
24,
126
]
],
[
[
597,
6,
3486
],
[
3486,
45,
126
]
],
[
[
597,
63,
168
],
[
168,
23... | [
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenytoin"
],
... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Chloramphenicol (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Warfarin (Compound)
Chloramphenico... |
DB00307 | DB00641 | 1,101 | 467 | [
"DDInter202",
"DDInter1675"
] | Bexarotene | Simvastatin | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
1101,
24,
467
]
],
[
[
1101,
6,
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],
[
8374,
45,
467
]
],
[
[
1101,
21,
29404
],
[
29404,
60,
467
]
],
[
[
1101,
63,
1428
],
[
1428... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Simvastatin (Compound)
Bexarotene (Compound) causes Cataract (Side Effect) and Cataract (Side Effect) is caused by Simvastatin (Compound)
Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Isradipine and Isra... |
DB00530 | DB00582 | 1,195 | 1,622 | [
"DDInter667",
"DDInter1946"
] | Erlotinib | Voriconazole | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections. It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increase... | Moderate | 1 | [
[
[
1195,
24,
1622
]
],
[
[
1195,
6,
8374
],
[
8374,
45,
1622
]
],
[
[
1195,
21,
28957
],
[
28957,
60,
1622
]
],
[
[
1195,
63,
752
],
[
75... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",... | Erlotinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Voriconazole (Compound)
Erlotinib (Compound) causes Arthralgia (Side Effect) and Arthralgia (Side Effect) is caused by Voriconazole (Compound)
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and C... |
DB00776 | DB08901 | 1,335 | 1,468 | [
"DDInter1360",
"DDInter1492"
] | Oxcarbazepine | Ponatinib | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
1335,
24,
1468
]
],
[
[
1335,
24,
478
],
[
478,
24,
1468
]
],
[
[
1335,
6,
7524
],
[
7524,
45,
1468
]
],
[
[
1335,
21,
29271
],
[
2927... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Oxcarbazepine (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ponatinib (Compound)
Oxcarbazepine (C... |
DB11901 | DB14881 | 913 | 180 | [
"DDInter107",
"DDInter1329"
] | Apalutamide | Oliceridine | Apalutamide is a potent androgen receptor (AR) antagonist that selectively binds to the ligand-binding domain of AR and blocks AR nuclear translocation or binding to androgen response elements. It has been used in trials studying the treatment of Prostate Cancer, Hepatic Impairment, Prostatic Neoplasms, Castration-Resi... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Major | 2 | [
[
[
913,
25,
180
]
],
[
[
913,
62,
112
],
[
112,
23,
180
]
],
[
[
913,
63,
401
],
[
401,
24,
180
]
],
[
[
913,
25,
124
],
[
124,
24,... | [
[
[
"Apalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Oliceridine"
]
],
[
[
"Apalutamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Apalutamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and... |
DB00220 | DB01181 | 798 | 1,532 | [
"DDInter1276",
"DDInter906"
] | Nelfinavir | Ifosfamide | Nelfinavir is a potent HIV-1 protease inhibitor. It is used in combination with other antiviral drugs in the treatment of HIV in both adults and children. Nelfinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Moderate | 1 | [
[
[
798,
24,
1532
]
],
[
[
798,
6,
7524
],
[
7524,
45,
1532
]
],
[
[
798,
21,
29209
],
[
29209,
60,
1532
]
],
[
[
798,
63,
1648
],
[
1648,... | [
[
[
"Nelfinavir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
]
],
[
[
"Nelfinavir",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compound)",... | Nelfinavir (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Ifosfamide (Compound)
Nelfinavir (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Ifosfamide (Compound)
Nelfinavir may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldes... |
DB00777 | DB01364 | 146 | 22 | [
"DDInter1537",
"DDInter650"
] | Propiomazine | Ephedrine | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Ephedrine was first described in western literature in 1888, as a naturally occurring component of the ephedra plant, along with [pseudoephedrine]. Ephedrine acts as both a direct and indirect sympathomimetic. It is an alpha- and beta-adrenergic receptor agonist; however, it also causes the indirect release of norepine... | Moderate | 1 | [
[
[
146,
24,
22
]
],
[
[
146,
6,
5214
],
[
5214,
45,
22
]
],
[
[
146,
64,
475
],
[
475,
23,
22
]
],
[
[
146,
24,
959
],
[
959,
24,
... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ephedrine"
]
],
[
[
"Propiomazine",
"{u} (Compound) binds {v} (Gene)",
"ADRA1A"
],
[
"ADRA1A",
"{u} (Gene) is bound by {v} (Compound... | Propiomazine (Compound) binds ADRA1A (Gene) and ADRA1A (Gene) is bound by Ephedrine (Compound)
Propiomazine may lead to a major life threatening interaction when taken with Morphine and Morphine may cause a minor interaction that can limit clinical effects when taken with Ephedrine
Propiomazine may cause a moderate int... |
DB08912 | DB14975 | 1,040 | 988 | [
"DDInter462",
"DDInter1949"
] | Dabrafenib | Voxelotor | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Major | 2 | [
[
[
1040,
25,
988
]
],
[
[
1040,
63,
222
],
[
222,
23,
988
]
],
[
[
1040,
24,
466
],
[
466,
23,
988
]
],
[
[
1040,
63,
251
],
[
251,
... | [
[
[
"Dabrafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voxelotor"
]
],
[
[
"Dabrafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutramin... | Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Voxelotor
Dabrafenib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darol... |
DB08899 | DB09128 | 129 | 1,241 | [
"DDInter649",
"DDInter231"
] | Enzalutamide | Brexpiprazole | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Brexpiprazole is an atypical antipsychotic and a novel D2 dopamine and serotonin 1A partial agonist called serotonin-dopamine activity modulator (SDAM). It has a high affinity for serotonin, dopamine and alpha (α)-adrenergic receptors. Although it is structurally similar to [aripiprazole], brexpiprazole has different b... | Moderate | 1 | [
[
[
129,
24,
1241
]
],
[
[
129,
63,
761
],
[
761,
24,
1241
]
],
[
[
129,
25,
741
],
[
741,
63,
1241
]
],
[
[
129,
24,
1662
],
[
1662,
... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brexpiprazole"
]
],
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
],
... | Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Saxagliptin and Saxagliptin may cause a moderate interaction that could exacerbate diseases when taken with Brexpiprazole
Enzalutamide may lead to a major life threatening interaction when taken with Rolapitant and Rolapitant m... |
DB00454 | DB00692 | 1,349 | 274 | [
"DDInter1150",
"DDInter1448"
] | Meperidine | Phentolamine | A narcotic analgesic that can be used for the relief of most types of moderate to severe pain, including postoperative pain and the pain of labor. Prolonged use may lead to dependence of the morphine type; withdrawal symptoms appear more rapidly than with morphine and are of shorter duration. | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
1349,
24,
274
]
],
[
[
1349,
21,
29118
],
[
29118,
60,
274
]
],
[
[
1349,
24,
530
],
[
530,
24,
274
]
],
[
[
1349,
24,
104
],
[
104,
... | [
[
[
"Meperidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Meperidine",
"{u} (Compound) causes {v} (Side Effect)",
"Tachycardia"
],
[
"Tachycardia",
"{u} (Side Effect) i... | Meperidine (Compound) causes Tachycardia (Side Effect) and Tachycardia (Side Effect) is caused by Phentolamine (Compound)
Meperidine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with P... |
DB06616 | DB13139 | 594 | 1,032 | [
"DDInter224",
"DDInter1063"
] | Bosutinib | Levosalbutamol | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). [Salbutamol] has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective ... | Moderate | 1 | [
[
[
594,
24,
1032
]
],
[
[
594,
64,
1220
],
[
1220,
23,
1032
]
],
[
[
594,
25,
1618
],
[
1618,
24,
1032
]
],
[
[
594,
24,
124
],
[
124,
... | [
[
[
"Bosutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
]
],
[
[
"Bosutinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"Dexam... | Bosutinib may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Levosalbutamol
Bosutinib may lead to a major life threatening interaction when taken with Cabozantinib and Cabozantinib may cause a mod... |
DB08881 | DB09104 | 868 | 286 | [
"DDInter1925",
"DDInter1118"
] | Vemurafenib | Magnesium hydroxide | Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann L... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
868,
24,
286
]
],
[
[
868,
64,
820
],
[
820,
23,
286
]
],
[
[
868,
63,
109
],
[
109,
23,
286
]
],
[
[
868,
62,
1382
],
[
1382,
2... | [
[
[
"Vemurafenib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Vemurafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
... | Vemurafenib may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Duloxetine and Duloxetine... |
DB00182 | DB00451 | 80 | 542 | [
"DDInter84",
"DDInter1064"
] | Amphetamine | Levothyroxine | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quant... | Moderate | 1 | [
[
[
80,
24,
542
]
],
[
[
80,
24,
1152
],
[
1152,
1,
542
]
],
[
[
80,
21,
28722
],
[
28722,
60,
542
]
],
[
[
80,
40,
1144
],
[
1144,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
]
],
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
... | Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine (Compound) resembles Levothyroxine (Compound)
Amphetamine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Levothyroxine (Compound)
Amphetamine (Compound) resembles Nateg... |
DB00626 | DB01135 | 1,441 | 648 | [
"DDInter161",
"DDInter590"
] | Bacitracin | Doxacurium | Bacitracin is a combination of at least 9 bacitracins.[A955,A181952] 60-80% of commercially prepared bacitracin is bacitracin A. The bacillus that produces bacitracin was first isolated from a knee scrape in 1945 from the knee wound of a child named Margaret Tracy. Bacitracin was granted FDA approval on 29 July 1948.[A... | Doxacurium chloride is a long-acting, nondepolarizing skeletal muscle relaxant for intravenous administration. | Moderate | 1 | [
[
[
1441,
24,
648
]
],
[
[
1441,
24,
1319
],
[
1319,
40,
648
]
],
[
[
1441,
63,
91
],
[
91,
24,
648
]
],
[
[
1441,
25,
361
],
[
361,
... | [
[
[
"Bacitracin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxacurium"
]
],
[
[
"Bacitracin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mivacurium"
],
[
... | Bacitracin may cause a moderate interaction that could exacerbate diseases when taken with Mivacurium and Mivacurium (Compound) resembles Doxacurium (Compound)
Bacitracin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may cause a moderate interaction that could... |
DB00075 | DB11248 | 541 | 1,193 | [
"DDInter1250",
"DDInter1965"
] | Muromonab | Zinc gluconate | Murine monoclonal antibody specific to CD3 T-cell lymphocyte antigens. More specifically it is a purified murine (mouse) monoclonal antibody, directed against the CD3 (T3) receptor on the surface of human T-cells (T-lymphocytes) cultured using the murine ascites method. Muromonab is 93% monomeric immune globulin G type... | Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA . It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and wi... | Minor | 0 | [
[
[
541,
23,
1193
]
],
[
[
541,
24,
1531
],
[
1531,
23,
1193
]
],
[
[
541,
24,
270
],
[
270,
62,
1193
]
],
[
[
541,
25,
1259
],
[
1259,
... | [
[
[
"Muromonab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc gluconate"
]
],
[
[
"Muromonab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Canakinumab"
],
[
... | Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate
Muromonab may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocr... |
DB08899 | DB08912 | 129 | 1,040 | [
"DDInter649",
"DDInter462"
] | Enzalutamide | Dabrafenib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Dabrafenib mesylate (Tafinlar) is a reversible ATP-competitive kinase inhibitor and targets the MAPK pathway. It was approved on May 29, 2013, for the treatment of melanoma with V600E or V6000K mutation. It was also used for metastatic non-small cell lung cancer with the same mutation. In May 2018, Tafinlar (dabrafenib... | Moderate | 1 | [
[
[
129,
24,
1040
]
],
[
[
129,
6,
4973
],
[
4973,
45,
1040
]
],
[
[
129,
54,
19201
],
[
19201,
15,
1040
]
],
[
[
129,
21,
29062
],
[
2906... | [
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dabrafenib"
]
],
[
[
"Enzalutamide",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)... | Enzalutamide (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dabrafenib (Compound)
Enzalutamide (Compound) is included by Cytochrome P450 2C19 Inducers (Pharmacologic Class) and Cytochrome P450 2C19 Inducers (Pharmacologic Class) includes Dabrafenib (Compound)
Enzalutamide (Compound) causes Neutropenia (Side... |
DB00850 | DB11837 | 1,630 | 1,297 | [
"DDInter1432",
"DDInter1351"
] | Perphenazine | Osilodrostat | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1630,
24,
1297
]
],
[
[
1630,
23,
112
],
[
112,
23,
1297
]
],
[
[
1630,
24,
222
],
[
222,
23,
1297
]
],
[
[
1630,
1,
623
],
[
623,
... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Perphenazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Perphenazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine a... |
DB00903 | DB01240 | 1,680 | 885 | [
"DDInter686",
"DDInter657"
] | Etacrynic acid | Epoprostenol | A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as ... | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Moderate | 1 | [
[
[
1680,
24,
885
]
],
[
[
1680,
63,
1061
],
[
1061,
1,
885
]
],
[
[
1680,
21,
28714
],
[
28714,
60,
885
]
],
[
[
1680,
63,
1512
],
[
1512... | [
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]
],
[
[
"Etacrynic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
... | Etacrynic acid may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil (Compound) resembles Epoprostenol (Compound)
Etacrynic acid (Compound) causes Asthenia (Side Effect) and Asthenia (Side Effect) is caused by Epoprostenol (Compound)
Etacrynic acid may cause a mod... |
DB00601 | DB09241 | 453 | 1,629 | [
"DDInter1073",
"DDInter1186"
] | Linezolid | Methylene blue | Linezolid is a synthetic antibiotic which is used for the treatment of infections caused by aerobic Gram-positive bacteria. Its effects are bacteriostatic against both enterococci and staphylococci and bactericidal against most isolates of streptococci. Linezolid exerts its antibacterial activity by inhibiting the init... | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
453,
25,
1629
]
],
[
[
453,
24,
1148
],
[
1148,
24,
1629
]
],
[
[
453,
25,
874
],
[
874,
24,
1629
]
],
[
[
453,
64,
73
],
[
73,
... | [
[
[
"Linezolid",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Linezolid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
"Isopre... | Linezolid may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Linezolid may lead to a major life threatening interaction when taken with Epinephrine and Epinephrine ma... |
DB00014 | DB01611 | 521 | 1,487 | [
"DDInter839",
"DDInter893"
] | Goserelin | Hydroxychloroquine | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
521,
24,
1487
]
],
[
[
521,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
521,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
521,
23,
1247
],
[
1247... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
... | Goserelin may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Goserelin (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)... |
DB00159 | DB09075 | 940 | 498 | [
"DDInter903",
"DDInter621"
] | Icosapent | Edoxaban | Important polyunsaturated fatty acid found in fish oils. It serves as the precursor for the prostaglandin-3 and thromboxane-3 families. A diet rich in eicosapentaenoic acid lowers serum lipid concentration, reduces incidence of cardiovascular disorders, prevents platelet aggregation, and inhibits arachidonic acid conve... | Edoxaban is a member of the Novel Oral Anti-Coagulants (NOACs) class of drugs, and is a rapidly acting, oral, selective factor Xa inhibitor. By inhibiting factor Xa, a key protein in the coagulation cascade, edoxaban prevents the stepwise amplification of protein factors needed to form blood clots. It is indicated to r... | Moderate | 1 | [
[
[
940,
24,
498
]
],
[
[
940,
63,
582
],
[
582,
25,
498
]
],
[
[
940,
24,
714
],
[
714,
25,
498
]
],
[
[
940,
24,
283
],
[
283,
64,... | [
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Edoxaban"
]
],
[
[
"Icosapent",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reteplase"
],
[
"... | Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Reteplase and Reteplase may lead to a major life threatening interaction when taken with Edoxaban
Icosapent may cause a moderate interaction that could exacerbate diseases when taken with Iloprost and Iloprost may lead to a major ... |
DB00277 | DB00418 | 1,031 | 536 | [
"DDInter1791",
"DDInter1650"
] | Theophylline | Secobarbital | A methylxanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Mechanistically, theophylline acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Theophylline is marketed under seve... | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Moderate | 1 | [
[
[
1031,
24,
536
]
],
[
[
1031,
24,
1023
],
[
1023,
1,
536
]
],
[
[
1031,
63,
288
],
[
288,
1,
536
]
],
[
[
1031,
24,
682
],
[
682,
... | [
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
]
],
[
[
"Theophylline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentobarbital"
],... | Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Pentobarbital and Pentobarbital (Compound) resembles Secobarbital (Compound)
Theophylline may cause a moderate interaction that could exacerbate diseases when taken with Butalbital and Butalbital (Compound) resembles Secobarbit... |
DB01319 | DB12267 | 34 | 1,476 | [
"DDInter777",
"DDInter233"
] | Fosamprenavir | Brigatinib | Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
34,
25,
1476
]
],
[
[
34,
25,
1135
],
[
1135,
23,
1476
]
],
[
[
34,
63,
168
],
[
168,
23,
1476
]
],
[
[
34,
64,
629
],
[
629,
24... | [
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Fosamprenavir",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{... | Fosamprenavir may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Fosamprenavir may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may caus... |
DB00615 | DB09073 | 690 | 951 | [
"DDInter1589",
"DDInter1379"
] | Rifabutin | Palbociclib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Palbociclib is a piperazine pyridopyrimidine that acts in the cell cycle machinery. It is a second generation cyclin-dependent kinase inhibitor selected from a group of pyridopyrimidine compounds due to its favorable physical and pharmaceutical properties. Palbociclib was developed by Pfizer Inc after the discovery tha... | Major | 2 | [
[
[
690,
25,
951
]
],
[
[
690,
25,
1476
],
[
1476,
63,
951
]
],
[
[
690,
63,
134
],
[
134,
24,
951
]
],
[
[
690,
24,
405
],
[
405,
6... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Palbociclib"
]
],
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
],
[
"Brigatinib",
"{u} ma... | Rifabutin may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Palbociclib
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause... |
DB09054 | DB10795 | 384 | 221 | [
"DDInter905",
"DDInter1486"
] | Idelalisib | Poliovirus type 1 antigen (formaldehyde inactivated) | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
384,
24,
221
]
],
[
[
384,
63,
36
],
[
36,
24,
221
]
],
[
[
384,
64,
581
],
[
581,
24,
221
]
],
[
[
384,
25,
351
],
[
351,
63,
... | [
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Idelalisib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Idelalisib may lead to a major life threatening interaction when taken wit... |
DB01233 | DB08815 | 1,311 | 154 | [
"DDInter1197",
"DDInter1104"
] | Metoclopramide | Lurasidone | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Major | 2 | [
[
[
1311,
25,
154
]
],
[
[
1311,
6,
2250
],
[
2250,
45,
154
]
],
[
[
1311,
21,
29175
],
[
29175,
60,
154
]
],
[
[
1311,
63,
1532
],
[
1532... | [
[
[
"Metoclopramide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurasidone"
]
],
[
[
"Metoclopramide",
"{u} (Compound) binds {v} (Gene)",
"DRD2"
],
[
"DRD2",
"{u} (Gene) is bound by {v} (Compound)",
"Lur... | Metoclopramide (Compound) binds DRD2 (Gene) and DRD2 (Gene) is bound by Lurasidone (Compound)
Metoclopramide (Compound) causes Galactorrhoea (Side Effect) and Galactorrhoea (Side Effect) is caused by Lurasidone (Compound)
Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Ifo... |
DB06176 | DB08820 | 1,342 | 1,478 | [
"DDInter1616",
"DDInter997"
] | Romidepsin | Ivacaftor | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1342,
24,
1478
]
],
[
[
1342,
64,
318
],
[
318,
23,
1478
]
],
[
[
1342,
63,
479
],
[
479,
23,
1478
]
],
[
[
1342,
63,
543
],
[
543,
... | [
[
[
"Romidepsin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escitalop... | Romidepsin may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Ivacaftor
Romidepsin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a... |
DB00694 | DB04953 | 51 | 495 | [
"DDInter485",
"DDInter708"
] | Daunorubicin | Ezogabine | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
51,
24,
495
]
],
[
[
51,
21,
28997
],
[
28997,
60,
495
]
],
[
[
51,
23,
112
],
[
112,
23,
495
]
],
[
[
51,
63,
1494
],
[
1494,
2... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Daunorubicin",
"{u} (Compound) causes {v} (Side Effect)",
"Ill-defined disorder"
],
[
"Ill-defined disorder",
"... | Daunorubicin (Compound) causes Ill-defined disorder (Side Effect) and Ill-defined disorder (Side Effect) is caused by Ezogabine (Compound)
Daunorubicin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effe... |
DB00675 | DB04938 | 888 | 1,423 | [
"DDInter1744",
"DDInter1353"
] | Tamoxifen | Ospemifene | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Ospemifene is a new selective non-hormonal estrogen receptor modulator (SERM) that is used for the treatment of moderate to severe dyspareunia, a symptom of vulvar and vaginal atrophy, due to menopause. FDA approved on February 26, 2013. | Moderate | 1 | [
[
[
888,
35,
1423
]
],
[
[
888,
24,
485
],
[
485,
40,
1423
]
],
[
[
888,
40,
11234
],
[
11234,
1,
1423
]
],
[
[
888,
1,
596
],
[
596,
... | [
[
[
"Tamoxifen",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ospemifene"
]
],
[
[
"Tamoxifen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken wit... | Tamoxifen (Compound) resembles Ospemifene (Compound) and
Tamoxifen may cause a moderate interaction that could exacerbate diseases when taken with Pentamidine and Pentamidine (Compound) resembles Ospemifene (Compound)
Tamoxifen (Compound) resembles Benzyl Benzoate (Compound) and Benzyl Benzoate (Compound) resembles Osp... |
DB00495 | DB01611 | 139 | 1,487 | [
"DDInter1961",
"DDInter893"
] | Zidovudine | Hydroxychloroquine | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Moderate | 1 | [
[
[
139,
24,
1487
]
],
[
[
139,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
139,
24,
663
],
[
663,
23,
1487
]
],
[
[
139,
63,
168
],
[
168,
... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Zidovudine",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) i... | Zidovudine (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with... |
DB00741 | DB01045 | 167 | 463 | [
"DDInter885",
"DDInter1590"
] | Hydrocortisone | Rifampicin | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
167,
24,
463
]
],
[
[
167,
63,
690
],
[
690,
40,
463
]
],
[
[
167,
6,
21998
],
[
21998,
45,
463
]
],
[
[
167,
63,
1101
],
[
1101,
... | [
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Hydrocortisone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
... | Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Hydrocortisone (Compound) binds CYP3A7-CYP3A51P (Gene) and CYP3A7-CYP3A51P (Gene) is bound by Rifampicin (Compound)
Hydrocortisone may cause a moderate intera... |
DB01128 | DB06663 | 918 | 1,154 | [
"DDInter204",
"DDInter1398"
] | Bicalutamide | Pasireotide | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease. | Major | 2 | [
[
[
918,
25,
1154
]
],
[
[
918,
21,
28900
],
[
28900,
60,
1154
]
],
[
[
918,
62,
112
],
[
112,
23,
1154
]
],
[
[
918,
23,
907
],
[
907,
... | [
[
[
"Bicalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
]
],
[
[
"Bicalutamide",
"{u} (Compound) causes {v} (Side Effect)",
"Abdominal pain"
],
[
"Abdominal pain",
"{u} (Side Effect) is caus... | Bicalutamide (Compound) causes Abdominal pain (Side Effect) and Abdominal pain (Side Effect) is caused by Pasireotide (Compound)
Bicalutamide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when t... |
DB00445 | DB00637 | 322 | 1,557 | [
"DDInter655",
"DDInter128"
] | Epirubicin | Astemizole | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Moderate | 1 | [
[
[
322,
24,
1557
]
],
[
[
322,
25,
1568
],
[
1568,
64,
1557
]
],
[
[
322,
7,
2692
],
[
2692,
46,
1557
]
],
[
[
322,
18,
7669
],
[
7669,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Astemizole"
]
],
[
[
"Epirubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pimozide"
],
[
"Pimozide",
... | Epirubicin may lead to a major life threatening interaction when taken with Pimozide and Pimozide may lead to a major life threatening interaction when taken with Astemizole
Epirubicin (Compound) upregulates KIT (Gene) and KIT (Gene) is upregulated by Astemizole (Compound)
Epirubicin (Compound) downregulates DDIT4 (Gen... |
DB01168 | DB09068 | 1,053 | 1,427 | [
"DDInter1526",
"DDInter1948"
] | Procarbazine | Vortioxetine | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Major | 2 | [
[
[
1053,
25,
1427
]
],
[
[
1053,
63,
1061
],
[
1061,
24,
1427
]
],
[
[
1053,
24,
1311
],
[
1311,
24,
1427
]
],
[
[
1053,
64,
475
],
[
475... | [
[
[
"Procarbazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vortioxetine"
]
],
[
[
"Procarbazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
],
[
"Tr... | Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Treprostinil and Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Procarbazine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopram... |
DB01076 | DB12141 | 700 | 971 | [
"DDInter133",
"DDInter817"
] | Atorvastatin | Gilteritinib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
700,
24,
971
]
],
[
[
700,
24,
466
],
[
466,
62,
971
]
],
[
[
700,
63,
112
],
[
112,
23,
971
]
],
[
[
700,
24,
72
],
[
72,
24,
... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole... |
DB00780 | DB01067 | 551 | 959 | [
"DDInter1440",
"DDInter826"
] | Phenelzine | Glipizide | Phenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved under prescription by the name o... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
551,
24,
959
]
],
[
[
551,
63,
245
],
[
245,
40,
959
]
],
[
[
551,
24,
1411
],
[
1411,
1,
959
]
],
[
[
551,
6,
8374
],
[
8374,
4... | [
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Phenelzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Phenelzine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound... |
DB06176 | DB14568 | 1,342 | 982 | [
"DDInter1616",
"DDInter1000"
] | Romidepsin | Ivosidenib | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1342,
25,
982
]
],
[
[
1342,
62,
112
],
[
112,
23,
982
]
],
[
[
1342,
25,
976
],
[
976,
24,
982
]
],
[
[
1342,
63,
543
],
[
543,
... | [
[
[
"Romidepsin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Romidepsin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Romidepsin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Romidepsin may lead to a major life threatening interaction when taken with Tofacitinib and Tofacitinib may ca... |
DB00262 | DB00685 | 552 | 1,299 | [
"DDInter302",
"DDInter1887"
] | Carmustine | Trovafloxacin | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Trovafloxacin is a broad spectrum antibiotic that has been commonly marketed under the brand name Trovan by Pfizer. It exerts its antibacterial activity by inhibiting the uncoiling of supercoiled DNA in various bacteria by blocking the activity of DNA gyrase and topoisomerase IV. It was shown to be more effective again... | Minor | 0 | [
[
[
552,
23,
1299
]
],
[
[
552,
23,
872
],
[
872,
40,
1299
]
],
[
[
552,
21,
29028
],
[
29028,
60,
1299
]
],
[
[
552,
24,
995
],
[
995,
... | [
[
[
"Carmustine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Trovafloxacin"
]
],
[
[
"Carmustine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Gemifloxacin"
],
[
... | Carmustine may cause a minor interaction that can limit clinical effects when taken with Gemifloxacin and Gemifloxacin (Compound) resembles Trovafloxacin (Compound)
Carmustine (Compound) causes Encephalopathy (Side Effect) and Encephalopathy (Side Effect) is caused by Trovafloxacin (Compound)
Carmustine may cause a mod... |
DB00209 | DB00489 | 352 | 17 | [
"DDInter1886",
"DDInter1704"
] | Trospium | Sotalol | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | Sotalol is a methanesulfonanilide developed in 1960. It was the first of the class III anti arrhythmic drugs. Sotalol was first approved as an oral tablet on 30 October 1992. A racemic mixture of sotalol is currently formulated as a tablet, oral solution, and intravenous injection indicated for life threatening ventric... | Moderate | 1 | [
[
[
352,
24,
17
]
],
[
[
352,
24,
88
],
[
88,
40,
17
]
],
[
[
352,
21,
28880
],
[
28880,
60,
17
]
],
[
[
352,
24,
999
],
[
999,
24,
... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sotalol"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoprolol"
],
[
"Me... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Metoprolol and Metoprolol (Compound) resembles Sotalol (Compound)
Trospium (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Sotalol (Compound)
Trospium may cause a moderate interaction that could... |
DB00867 | DB06655 | 1,052 | 5 | [
"DDInter1606",
"DDInter1077"
] | Ritodrine | Liraglutide | Adrenergic beta-agonist used to control premature labor. | Victoza contains liraglutide, a synthetic analog of human glucagon-like peptide-1(GLP-1) and acts as a GLP-1 receptor agonist.[Label,A6932] Liraglutide is 97% similar to native human GLP-1, differing primarily by substituting arginine for lysine at position 34. Liraglutide is made by attaching a C-16 fatty acid (palmit... | Moderate | 1 | [
[
[
1052,
24,
5
]
],
[
[
1052,
62,
870
],
[
870,
24,
5
]
],
[
[
1052,
63,
245
],
[
245,
24,
5
]
],
[
[
1052,
35,
480
],
[
480,
24,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liraglutide"
]
],
[
[
"Ritodrine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Fludrocortisone"
],
[
... | Ritodrine may cause a minor interaction that can limit clinical effects when taken with Fludrocortisone and Fludrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Liraglutide
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride an... |
DB00207 | DB01229 | 1,570 | 973 | [
"DDInter157",
"DDInter1378"
] | Azithromycin | Paclitaxel (protein-bound) | Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It was initially approved by the FDA in 1991. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually tra... | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Moderate | 1 | [
[
[
1570,
24,
973
]
],
[
[
1570,
6,
8374
],
[
8374,
45,
973
]
],
[
[
1570,
18,
7380
],
[
7380,
46,
973
]
],
[
[
1570,
18,
4677
],
[
4677,
... | [
[
[
"Azithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Azithromycin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compoun... | Azithromycin may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Azithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Azithromycin (Compound) downregulates AKAP8L (Gene) and AKAP8L (Gene) is upregulated by Paclitaxel (Compound)
Azithromyc... |
DB05294 | DB06402 | 1,069 | 1,079 | [
"DDInter1917",
"DDInter1756"
] | Vandetanib | Telavancin | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Telavancin is a semi-synthetic derivative of vanocymycin that has bactericidal activity against Methicillin-resistant Staphylococcus aureus (MRSA) and other gram-positive bacteria. MRSA is an important pathogen capable of causing hospital-acquired pneumonia (HAP), ventilator-associated pneumonia (VAP), and skin and sub... | Major | 2 | [
[
[
1069,
25,
1079
]
],
[
[
1069,
21,
28680
],
[
28680,
60,
1079
]
],
[
[
1069,
62,
112
],
[
112,
23,
1079
]
],
[
[
1069,
24,
657
],
[
657... | [
[
[
"Vandetanib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Telavancin"
]
],
[
[
"Vandetanib",
"{u} (Compound) causes {v} (Side Effect)",
"Rash"
],
[
"Rash",
"{u} (Side Effect) is caused by {v} (Compound)",
... | Vandetanib (Compound) causes Rash (Side Effect) and Rash (Side Effect) is caused by Telavancin (Compound)
Vandetanib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Telavancin
Vand... |
DB08865 | DB15091 | 1,593 | 676 | [
"DDInter448",
"DDInter1901"
] | Crizotinib | Upadacitinib | Crizotinib is a tyrosine kinase receptor inhibitor used for the treatment of anaplastic lymphoma kinase (ALK) or ROS1-positive non-small cell lung cancer (NSCLC) tumors, as well as ALK-positive anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumor (IMT). By targeting the echinoderm microtubule-as... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Moderate | 1 | [
[
[
1593,
24,
676
]
],
[
[
1593,
63,
1249
],
[
1249,
24,
676
]
],
[
[
1593,
23,
283
],
[
283,
24,
676
]
],
[
[
1593,
24,
214
],
[
214,
... | [
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Upadacitinib"
]
],
[
[
"Crizotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
[
... | Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Crizotinib may cause a minor interaction that can limit clinical effects when taken with Fedratinib and Fedratin... |
DB08904 | DB15699 | 375 | 652 | [
"DDInter342",
"DDInter232"
] | Certolizumab pegol | Brexucabtagene autoleucel | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Major | 2 | [
[
[
375,
25,
652
]
],
[
[
375,
64,
259
],
[
259,
24,
652
]
],
[
[
375,
63,
1430
],
[
1430,
24,
652
]
],
[
[
375,
25,
270
],
[
270,
2... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
... | Certolizumab pegol may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Certolizumab pegol may cause a moderate interaction that could exacerbate diseases when taken with Sipul... |
DB00816 | DB14568 | 1,674 | 982 | [
"DDInter1346",
"DDInter1000"
] | Orciprenaline | Ivosidenib | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Major | 2 | [
[
[
1674,
25,
982
]
],
[
[
1674,
24,
1032
],
[
1032,
24,
982
]
],
[
[
1674,
63,
867
],
[
867,
24,
982
]
],
[
[
1674,
63,
472
],
[
472,
... | [
[
[
"Orciprenaline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
]
],
[
[
"Orciprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levosalbutamol"
],
[
"... | Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levosalbutamol and Levosalbutamol may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib
Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Olanzap... |
DB00065 | DB06810 | 581 | 397 | [
"DDInter923",
"DDInter1484"
] | Infliximab | Plicamycin | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Plicamycin is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Paget's disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. | Major | 2 | [
[
[
581,
25,
397
]
],
[
[
581,
24,
597
],
[
597,
24,
397
]
],
[
[
581,
24,
151
],
[
151,
63,
397
]
],
[
[
581,
25,
248
],
[
248,
24,... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Plicamycin"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chloramphenicol"
],
[
"Chlor... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Chloramphenicol and Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Plicamycin
Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A... |
DB00460 | DB00855 | 612 | 213 | [
"DDInter1929",
"DDInter72"
] | Verteporfin | Aminolevulinic acid | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis. [PubChem] | Major | 2 | [
[
[
612,
25,
213
]
],
[
[
612,
21,
28880
],
[
28880,
60,
213
]
],
[
[
612,
24,
1040
],
[
1040,
64,
213
]
],
[
[
612,
63,
10
],
[
10,
... | [
[
[
"Verteporfin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Aminolevulinic acid"
]
],
[
[
"Verteporfin",
"{u} (Compound) causes {v} (Side Effect)",
"Angiopathy"
],
[
"Angiopathy",
"{u} (Side Effect) is caused... | Verteporfin (Compound) causes Angiopathy (Side Effect) and Angiopathy (Side Effect) is caused by Aminolevulinic acid (Compound)
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may lead to a major life threatening interaction when taken with Aminolevu... |
DB00188 | DB06372 | 168 | 259 | [
"DDInter222",
"DDInter1594"
] | Bortezomib | Rilonacept | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
168,
24,
259
]
],
[
[
168,
63,
1461
],
[
1461,
23,
259
]
],
[
[
168,
24,
1330
],
[
1330,
63,
259
]
],
[
[
168,
23,
985
],
[
985,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab and Naxitamab m... |
DB01059 | DB06616 | 956 | 594 | [
"DDInter1313",
"DDInter224"
] | Norfloxacin | Bosutinib | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
956,
24,
594
]
],
[
[
956,
6,
8374
],
[
8374,
45,
594
]
],
[
[
956,
21,
28709
],
[
28709,
60,
594
]
],
[
[
956,
62,
112
],
[
112,
... | [
[
[
"Norfloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)"... | Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bosutinib (Compound)
Norfloxacin (Compound) causes Decreased appetite (Side Effect) and Decreased appetite (Side Effect) is caused by Bosutinib (Compound)
Norfloxacin may cause a minor interaction that can limit clinical effects when taken with Me... |
DB06674 | DB08879 | 908 | 632 | [
"DDInter837",
"DDInter173"
] | Golimumab | Belimumab | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Major | 2 | [
[
[
908,
25,
632
]
],
[
[
908,
62,
1461
],
[
1461,
23,
632
]
],
[
[
908,
23,
1114
],
[
1114,
62,
632
]
],
[
[
908,
25,
713
],
[
713,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belimumab"
]
],
[
[
"Golimumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Vitamin E"
],
[
"Vitamin E",
... | Golimumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Belimumab
Golimumab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate ma... |
DB00598 | DB00789 | 1,523 | 1,431 | [
"DDInter1013",
"DDInter796"
] | Labetalol | Gadopentetic acid | Labetalol is a racemic mixture of 2 diastereoisomers where dilevalol, the R,R' stereoisomer, makes up 25% of the mixture. Labetalol is formulated as an injection or tablets to treat hypertension.[L7727,L7730] Labetalol was granted FDA approval on 1 August 1984. | A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706) | Moderate | 1 | [
[
[
1523,
24,
1431
]
],
[
[
1523,
63,
457
],
[
457,
40,
1431
]
],
[
[
1523,
24,
808
],
[
808,
40,
1431
]
],
[
[
1523,
21,
28658
],
[
28658... | [
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadopentetic acid"
]
],
[
[
"Labetalol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gadodiamide"
],
... | Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Gadodiamide and Gadodiamide (Compound) resembles Gadopentetic acid (Compound)
Labetalol may cause a moderate interaction that could exacerbate diseases when taken with Gadobenic acid and Gadobenic acid (Compound) resembles Gadopen... |
DB06589 | DB06717 | 1,250 | 875 | [
"DDInter1400",
"DDInter778"
] | Pazopanib | Fosaprepitant | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Moderate | 1 | [
[
[
1250,
24,
875
]
],
[
[
1250,
63,
723
],
[
723,
1,
875
]
],
[
[
1250,
21,
29180
],
[
29180,
60,
875
]
],
[
[
1250,
24,
466
],
[
466,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fosaprepitant"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant (Compound) resembles Fosaprepitant (Compound)
Pazopanib (Compound) causes Abdominal distension (Side Effect) and Abdominal distension (Side Effect) is caused by Fosaprepitant (Compound)
Pazopanib may caus... |
DB01035 | DB15091 | 1,401 | 676 | [
"DDInter1524",
"DDInter1901"
] | Procainamide | Upadacitinib | A derivative of procaine with less CNS action. | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
1401,
25,
676
]
],
[
[
1401,
25,
1593
],
[
1593,
24,
676
]
],
[
[
1401,
64,
600
],
[
600,
24,
676
]
],
[
[
1401,
24,
1446
],
[
1446,
... | [
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Procainamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Crizotinib"
],
[
"Crizotinib",
... | Procainamide may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Procainamide may lead to a major life threatening interaction when taken with Fluconazole and Fluconazole may cause a moder... |
DB00342 | DB13074 | 1,181 | 877 | [
"DDInter1770",
"DDInter1110"
] | Terfenadine | Macimorelin | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Macimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts as an agonist of GH secretagogue receptor, or ghrelin receptor (GHS-R1a) to dose-dep... | Major | 2 | [
[
[
1181,
25,
877
]
],
[
[
1181,
23,
112
],
[
112,
23,
877
]
],
[
[
1181,
24,
673
],
[
673,
24,
877
]
],
[
[
1181,
25,
1662
],
[
1662,
... | [
[
[
"Terfenadine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Macimorelin"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metron... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Macimorelin
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and... |
DB00414 | DB06335 | 590 | 761 | [
"DDInter16",
"DDInter1646"
] | Acetohexamide | Saxagliptin | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
590,
24,
761
]
],
[
[
590,
62,
1103
],
[
1103,
23,
761
]
],
[
[
590,
24,
1491
],
[
1491,
63,
761
]
],
[
[
590,
24,
1577
],
[
1577,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Acetohexamide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Amcinonide"
],
... | Acetohexamide may cause a minor interaction that can limit clinical effects when taken with Amcinonide and Amcinonide may cause a minor interaction that can limit clinical effects when taken with Saxagliptin
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Midostaurin and Mi... |
DB01105 | DB11730 | 222 | 351 | [
"DDInter1665",
"DDInter1588"
] | Sibutramine | Ribociclib | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Minor | 0 | [
[
[
222,
23,
351
]
],
[
[
222,
24,
283
],
[
283,
62,
351
]
],
[
[
222,
24,
1627
],
[
1627,
23,
351
]
],
[
[
222,
63,
288
],
[
288,
2... | [
[
[
"Sibutramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ribociclib"
]
],
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Canna... |
DB00188 | DB14409 | 168 | 1,129 | [
"DDInter222",
"DDInter867"
] | Bortezomib | Human adenovirus e serotype 4 strain cl-68578 antigen | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
168,
24,
1129
]
],
[
[
168,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
168,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
168,
63,
1184
],
[
1184,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Bortezomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Bortezomib may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Bortezomib may cause a moderate interaction that could exacerbate diseases when take... |
DB00328 | DB06605 | 831 | 1,409 | [
"DDInter921",
"DDInter108"
] | Indomethacin | Apixaban | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
831,
25,
1409
]
],
[
[
831,
6,
10215
],
[
10215,
45,
1409
]
],
[
[
831,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
831,
24,
1040
],
[
104... | [
[
[
"Indomethacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Indomethacin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
"Api... | Indomethacin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Apixaban (Compound)
Indomethacin (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib an... |
DB00705 | DB01229 | 441 | 973 | [
"DDInter496",
"DDInter1378"
] | Delavirdine | Paclitaxel (protein-bound) | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Major | 2 | [
[
[
441,
25,
973
]
],
[
[
441,
24,
310
],
[
310,
63,
973
]
],
[
[
441,
6,
7524
],
[
7524,
45,
973
]
],
[
[
441,
21,
28779
],
[
28779,
... | [
[
[
"Delavirdine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
[
"Cabazit... | Delavirdine may lead to a major life threatening interaction when taken with Paclitaxel
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Delavirdine (Compound... |
DB00284 | DB01246 | 1,647 | 820 | [
"DDInter11",
"DDInter45"
] | Acarbose | Alimemazine | Acarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. It inhibits both pancreatic alpha-amylase and membrane-bound alpha-glucosidases - including intestinal glucoamylase, sucrase, maltase, and isomaltase - which are r... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
1647,
24,
820
]
],
[
[
1647,
24,
104
],
[
104,
40,
820
]
],
[
[
1647,
24,
401
],
[
401,
24,
820
]
],
[
[
1647,
24,
508
],
[
508,
... | [
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Acarbose",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
[
... | Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Acarbose may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that ... |
DB00086 | DB00374 | 1,167 | 1,061 | [
"DDInter1712",
"DDInter1852"
] | Streptokinase | Treprostinil | Streptokinase, is a sterile, purified preparation of a bacterial protein elaborated by group C (beta) -hemolytic streptococci. | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Moderate | 1 | [
[
[
1167,
24,
1061
]
],
[
[
1167,
24,
885
],
[
885,
40,
1061
]
],
[
[
1167,
23,
539
],
[
539,
62,
1061
]
],
[
[
1167,
24,
914
],
[
914,
... | [
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Treprostinil"
]
],
[
[
"Streptokinase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epoprostenol"
]... | Streptokinase may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Epoprostenol (Compound) resembles Treprostinil (Compound)
Streptokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that ca... |
DB00470 | DB00880 | 530 | 359 | [
"DDInter601",
"DDInter360"
] | Dronabinol | Chlorothiazide | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Moderate | 1 | [
[
[
530,
24,
359
]
],
[
[
530,
24,
1577
],
[
1577,
1,
359
]
],
[
[
530,
21,
28762
],
[
28762,
60,
359
]
],
[
[
530,
24,
820
],
[
820,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorothiazide"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroflumethiazide"
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Hydroflumethiazide and Hydroflumethiazide (Compound) resembles Chlorothiazide (Compound)
Dronabinol (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Chlorothiazide (Compound)
Dronabinol may cause a... |
DB01611 | DB01764 | 1,487 | 805 | [
"DDInter893",
"DDInter469"
] | Hydroxychloroquine | Dalfopristin | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Dalfopristin is a combination of two antibiotics (Dalfopristin and quinupristin) used to treat infections by staphylococci and by vancomycin-resistant Enterococcus faecium. It is not effective against Enterococcus faecalis infections. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome ... | Moderate | 1 | [
[
[
1487,
24,
805
]
],
[
[
1487,
24,
283
],
[
283,
62,
805
]
],
[
[
1487,
25,
1618
],
[
1618,
63,
805
]
],
[
[
1487,
24,
384
],
[
384,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dalfopristin"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratini... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Dalfopristin
Hydroxychloroquine may lead to a major life threatening interaction when taken with Cabozantinib and Cab... |
DB00990 | DB15093 | 1,547 | 1,654 | [
"DDInter705",
"DDInter1698"
] | Exemestane | Somapacitan | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | Somapacitan, also known as NNC0195-0092, is a growth hormone analog indicated to treat adults with growth hormone deficiency.[A219126,L15661] This human growth hormone analog differs by the creation of an albumin binding site, and prolonging the effect so that it requires weekly dosing rather than daily. Somapacitan wa... | Moderate | 1 | [
[
[
1547,
24,
1654
]
],
[
[
1547,
24,
868
],
[
868,
24,
1654
]
],
[
[
1547,
1,
1573
],
[
1573,
24,
1654
]
],
[
[
1547,
63,
629
],
[
629,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somapacitan"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
[
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan
Exemestane (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that co... |
DB00022 | DB08908 | 268 | 713 | [
"DDInter1408",
"DDInter564"
] | Peginterferon alfa-2b | Dimethyl fumarate | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis.[A253942,L43752] The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MM... | Moderate | 1 | [
[
[
268,
24,
713
]
],
[
[
268,
24,
996
],
[
996,
24,
713
]
],
[
[
268,
24,
270
],
[
270,
63,
713
]
],
[
[
268,
63,
491
],
[
491,
24,... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dimethyl fumarate"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Bedaquiline and Bedaquiline may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when t... |
DB00196 | DB08871 | 600 | 36 | [
"DDInter743",
"DDInter666"
] | Fluconazole | Eribulin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
600,
24,
36
]
],
[
[
600,
24,
122
],
[
122,
23,
36
]
],
[
[
600,
23,
1247
],
[
1247,
23,
36
]
],
[
[
600,
24,
519
],
[
519,
24,
... | [
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Verapamil"
],
[
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Verapamil and Verapamil may cause a minor interaction that can limit clinical effects when taken with Eribulin
Fluconazole may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfam... |
DB00258 | DB09498 | 666 | 810 | [
"DDInter270",
"DDInter1715"
] | Calcium acetate | Strontium chloride Sr-89 | The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form. | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
666,
24,
810
]
],
[
[
666,
21,
28658
],
[
28658,
60,
134
],
[
134,
24,
810
]
],
[
[
666,
21,
28930
],
[
28930,
60,
1064
],
[
1064,
2... | [
[
[
"Calcium acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Calcium acetate",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u}... | Calcium acetate (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Vinorelbine (Compound) and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Calcium acetate (Compound) causes Depressed level of consciousness (Side Effect... |
DB00476 | DB09122 | 109 | 1,613 | [
"DDInter608",
"DDInter1409"
] | Duloxetine | Peginterferon beta-1a | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
109,
24,
1613
]
],
[
[
109,
24,
1274
],
[
1274,
24,
1613
]
],
[
[
109,
63,
1503
],
[
1503,
24,
1613
]
],
[
[
109,
24,
1383
],
[
1383,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Flurbiprofen"
... | Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Flurbiprofen and Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Duloxetine may cause a moderate interaction that could exacerbate diseases when taken with Lindan... |
DB00196 | DB09061 | 600 | 1,627 | [
"DDInter743",
"DDInter284"
] | Fluconazole | Cannabidiol | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Minor | 0 | [
[
[
600,
23,
1627
]
],
[
[
600,
24,
723
],
[
723,
23,
1627
]
],
[
[
600,
24,
760
],
[
760,
62,
1627
]
],
[
[
600,
23,
609
],
[
609,
... | [
[
[
"Fluconazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cannabidiol"
]
],
[
[
"Fluconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aprepitant"
],
[
... | Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant and Aprepitant may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobic... |
DB01080 | DB01234 | 855 | 1,220 | [
"DDInter1933",
"DDInter513"
] | Vigabatrin | Dexamethasone | Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms. It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although... | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Major | 2 | [
[
[
855,
25,
1220
]
],
[
[
855,
64,
175
],
[
175,
40,
1220
]
],
[
[
855,
64,
167
],
[
167,
1,
1220
]
],
[
[
855,
25,
617
],
[
617,
4... | [
[
[
"Vigabatrin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
]
],
[
[
"Vigabatrin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triamcinolone"
],
[
"Triamcinolone",
... | Vigabatrin may lead to a major life threatening interaction when taken with Triamcinolone and Triamcinolone (Compound) resembles Dexamethasone (Compound)
Vigabatrin may lead to a major life threatening interaction when taken with Hydrocortisone and Hydrocortisone (Compound) resembles Dexamethasone (Compound)
Vigabatrin... |
DB00619 | DB12941 | 1,419 | 466 | [
"DDInter909",
"DDInter481"
] | Imatinib | Darolutamide | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
1419,
24,
466
]
],
[
[
1419,
63,
1622
],
[
1622,
23,
466
]
],
[
[
1419,
24,
1623
],
[
1623,
23,
466
]
],
[
[
1419,
25,
484
],
[
484,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
],
[
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium and I... |
DB00594 | DB09134 | 863 | 1,552 | [
"DDInter68",
"DDInter966"
] | Amiloride | Ioversol | A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions... | Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues. Iodine has a high atomic density, which gives it the ability to attenuate X-rays. The intravascular administration of iodine compounds, such as ioversol,... | Moderate | 1 | [
[
[
863,
24,
1552
]
],
[
[
863,
63,
1648
],
[
1648,
24,
1552
]
],
[
[
863,
24,
848
],
[
848,
25,
1552
]
],
[
[
863,
63,
1645
],
[
1645,
... | [
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ioversol"
]
],
[
[
"Amiloride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Ioversol
Amiloride may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen... |
DB00564 | DB09143 | 1,236 | 313 | [
"DDInter293",
"DDInter1701"
] | Carbamazepine | Sonidegib | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Sonidegib is a Hedgehog signaling pathway inhibitor (via smoothened antagonism) developed as an anticancer agent by Novartis. It was FDA approved in 2015 for the treatment of basal cell carcinoma. | Major | 2 | [
[
[
1236,
25,
313
]
],
[
[
1236,
25,
478
],
[
478,
24,
313
]
],
[
[
1236,
25,
484
],
[
484,
63,
313
]
],
[
[
1236,
24,
1320
],
[
1320,
... | [
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sonidegib"
]
],
[
[
"Carbamazepine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nilotinib"
],
[
"Nilotinib",
"{u... | Carbamazepine may lead to a major life threatening interaction when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Sonidegib
Carbamazepine may lead to a major life threatening interaction when taken with Entrectinib and Entrectinib may cause a moderate... |
DB09048 | DB09074 | 555 | 1,362 | [
"DDInter1284",
"DDInter1327"
] | Netupitant | Olaparib | Netupitant is an antiemitic drug approved by the FDA in October 2014 for use in combination with palonosetron for the prevention of acute and delayed vomiting and nausea associated with cancer chemotherapy including highly emetogenic chemotherapy. Netupitant is a neurokinin 1 receptor antagonist. The combination drug i... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Major | 2 | [
[
[
555,
25,
1362
]
],
[
[
555,
63,
896
],
[
896,
24,
1362
]
],
[
[
555,
64,
1478
],
[
1478,
24,
1362
]
],
[
[
555,
24,
214
],
[
214,
... | [
[
[
"Netupitant",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Olaparib"
]
],
[
[
"Netupitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
"Etoposide",
... | Netupitant may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Netupitant may lead to a major life threatening interaction when taken with Ivacaftor and Ivacaftor may cause a mode... |
DB00108 | DB01222 | 1,066 | 617 | [
"DDInter1268",
"DDInter246"
] | Natalizumab | Budesonide | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Major | 2 | [
[
[
1066,
25,
617
]
],
[
[
1066,
25,
251
],
[
251,
1,
617
]
],
[
[
1066,
23,
1461
],
[
1461,
23,
617
]
],
[
[
1066,
23,
1193
],
[
1193,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Budesonide"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Betamethasone"
],
[
"Betamethasone",
... | Natalizumab may lead to a major life threatening interaction when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Natalizumab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical ... |
DB00408 | DB01176 | 1,408 | 537 | [
"DDInter1099",
"DDInter453"
] | Loxapine | Cyclizine | An antipsychotic agent used in schizophrenia. [PubChem] | A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935) | Moderate | 1 | [
[
[
1408,
35,
537
]
],
[
[
1408,
24,
1511
],
[
1511,
63,
537
]
],
[
[
1408,
63,
1242
],
[
1242,
24,
537
]
],
[
[
1408,
24,
104
],
[
104,
... | [
[
[
"Loxapine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
]
],
[
[
"Loxapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Loxapine (Compound) resembles Cyclizine (Compound) and
Loxapine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine
Loxapine may cause a moderate interaction that could exace... |
DB00553 | DB04571 | 92 | 226 | [
"DDInter1177",
"DDInter1877"
] | Methoxsalen | Trioxsalen | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia. Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction with UV-A (the least damaging for... | Moderate | 1 | [
[
[
92,
24,
226
]
],
[
[
92,
7,
13128
],
[
13128,
46,
226
]
],
[
[
92,
54,
19236
],
[
19236,
15,
226
]
],
[
[
92,
18,
10375
],
[
10375,
... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trioxsalen"
]
],
[
[
"Methoxsalen",
"{u} (Compound) upregulates {v} (Gene)",
"NARFL"
],
[
"NARFL",
"{u} (Gene) is upregulated by {v} ... | Methoxsalen (Compound) upregulates NARFL (Gene) and NARFL (Gene) is upregulated by Trioxsalen (Compound)
Methoxsalen (Compound) is included by Psoralens (Pharmacologic Class) and Psoralens (Pharmacologic Class) includes Trioxsalen (Compound)
Methoxsalen (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downre... |
DB00694 | DB15982 | 51 | 1,339 | [
"DDInter485",
"DDInter193"
] | Daunorubicin | Berotralstat | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
51,
24,
1339
]
],
[
[
51,
24,
1213
],
[
1213,
24,
1339
]
],
[
[
51,
25,
351
],
[
351,
24,
1339
]
],
[
[
51,
64,
11
],
[
11,
24,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
],
... | Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Dasatinib and Dasatinib may cause a moderate interaction that could exacerbate diseases when taken with Berotralstat
Daunorubicin may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may ca... |
DB00008 | DB00995 | 491 | 1,112 | [
"DDInter1407",
"DDInter139"
] | Peginterferon alfa-2a | Auranofin | Peginterferon alfa-2a is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Moderate | 1 | [
[
[
491,
24,
1112
]
],
[
[
491,
24,
36
],
[
36,
63,
1112
]
],
[
[
491,
24,
134
],
[
134,
24,
1112
]
],
[
[
491,
63,
1057
],
[
1057,
... | [
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Auranofin"
]
],
[
[
"Peginterferon alfa-2a",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribul... | Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Auranofin
Peginterferon alfa-2a may cause a moderate interaction that could exacerbate diseases when taken with Vino... |
DB00065 | DB01030 | 581 | 869 | [
"DDInter923",
"DDInter1835"
] | Infliximab | Topotecan | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I. | Major | 2 | [
[
[
581,
25,
869
]
],
[
[
581,
25,
613
],
[
613,
24,
869
]
],
[
[
581,
25,
310
],
[
310,
63,
869
]
],
[
[
581,
24,
1270
],
[
1270,
6... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Topotecan"
]
],
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Irinotecan"
],
[
"Irinotecan",
"{u} ma... | Infliximab may lead to a major life threatening interaction when taken with Irinotecan and Irinotecan may cause a moderate interaction that could exacerbate diseases when taken with Topotecan
Infliximab may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate int... |
DB00991 | DB09133 | 97 | 1,527 | [
"DDInter1358",
"DDInter965"
] | Oxaprozin | Iothalamic acid | Oxaprozin is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID), used to relieve the inflammation, swelling, stiffness, and joint pain associated with osteoarthritis and rheumatoid arthritis. | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
97,
25,
1527
]
],
[
[
97,
63,
91
],
[
91,
25,
1527
]
],
[
[
97,
24,
848
],
[
848,
25,
1527
]
],
[
[
97,
40,
998
],
[
998,
25,
... | [
[
[
"Oxaprozin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Oxaprozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
"Vancomy... | Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may lead to a major life threatening interaction when taken with Iothalamic acid
Oxaprozin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may lead ... |
DB00363 | DB01229 | 695 | 973 | [
"DDInter419",
"DDInter1377"
] | Clozapine | Paclitaxel | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Major | 2 | [
[
[
695,
25,
973
]
],
[
[
695,
25,
310
],
[
310,
63,
973
]
],
[
[
695,
6,
8374
],
[
8374,
45,
973
]
],
[
[
695,
7,
16703
],
[
16703,
... | [
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Paclitaxel"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabazitaxel"
],
[
"Cabazitaxel",
"{u} m... | Clozapine may lead to a major life threatening interaction when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Clozapine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Paclitaxel (Compound)
Clozapine (Compound) upregulates ... |
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