drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01242 | DB09039 | 1,237 | 1,670 | [
"DDInter410",
"DDInter629"
] | Clomipramine | Eliglustat | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Eliglustat is a glucosylceramide synthase inhibitor used for the long-term treatment of type 1 Gaucher disease.[A3752,L41404] Gaucher disease is a rare genetic disorder characterized by the deficiency of acid β-glucosidase, an enzyme that converts glucosylceramide into glucose and ceramide. In patients with Gaucher dis... | Moderate | 1 | [
[
[
1237,
24,
1670
]
],
[
[
1237,
63,
121
],
[
121,
24,
1670
]
],
[
[
1237,
24,
1409
],
[
1409,
24,
1670
]
],
[
[
1237,
40,
1164
],
[
1164... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eliglustat"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
],
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine and Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Apixaban and ... |
DB00978 | DB09330 | 739 | 985 | [
"DDInter1084",
"DDInter1352"
] | Lomefloxacin | Osimertinib | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Major | 2 | [
[
[
739,
25,
985
]
],
[
[
739,
62,
112
],
[
112,
23,
985
]
],
[
[
739,
62,
134
],
[
134,
24,
985
]
],
[
[
739,
24,
480
],
[
480,
24,... | [
[
[
"Lomefloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Osimertinib"
]
],
[
[
"Lomefloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osimertinib
Lomefloxacin may cause a minor interaction that can limit clinical effects when taken with Vinorelbine and ... |
DB00477 | DB00501 | 216 | 752 | [
"DDInter363",
"DDInter380"
] | Chlorpromazine | Cimetidine | The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the tr... | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Minor | 0 | [
[
[
216,
23,
752
]
],
[
[
216,
6,
4973
],
[
4973,
45,
752
]
],
[
[
216,
18,
8954
],
[
8954,
57,
752
]
],
[
[
216,
21,
28778
],
[
28778,
... | [
[
[
"Chlorpromazine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Cimetidine"
]
],
[
[
"Chlorpromazine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Chlorpromazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Cimetidine (Compound)
Chlorpromazine (Compound) downregulates HACD3 (Gene) and HACD3 (Gene) is downregulated by Cimetidine (Compound)
Chlorpromazine (Compound) causes Anaphylactic shock (Side Effect) and Anaphylactic shock (Side Effect) is caused... |
DB00108 | DB00262 | 1,066 | 552 | [
"DDInter1268",
"DDInter302"
] | Natalizumab | Carmustine | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogen... | Major | 2 | [
[
[
1066,
25,
552
]
],
[
[
1066,
25,
377
],
[
377,
63,
552
]
],
[
[
1066,
64,
305
],
[
305,
24,
552
]
],
[
[
1066,
24,
1136
],
[
1136,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Carmustine"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mitomycin"
],
[
"Mitomycin",
"{u} m... | Natalizumab may lead to a major life threatening interaction when taken with Mitomycin and Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Carmustine
Natalizumab may lead to a major life threatening interaction when taken with Asparaginase Escherichia coli and Asparaginase Esch... |
DB04896 | DB05578 | 901 | 330 | [
"DDInter1220",
"DDInter1566"
] | Milnacipran | Ramucirumab | Milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and like many agents in this category was originally developed for and continues to be approved and indicated for the treatment of depression [F3928, F3934, A175786, A175951]. Furthermore, in 2009 the US FDA approved milnacipran for the a... | Ramucirumab is a human monoclonal antibody (IgG1) against vascular endothelial growth factor receptor 2 (VEGFR2), a type II trans-membrane tyrosine kinase receptor expressed on endothelial cells. By binding to VEGFR2, ramucirumab prevents binding of its ligands (VEGF-A, VEGF-C, and VEGF-D), thereby preventing VEGF-stim... | Moderate | 1 | [
[
[
901,
24,
330
]
],
[
[
901,
40,
41
],
[
41,
63,
330
]
],
[
[
901,
24,
384
],
[
384,
63,
330
]
],
[
[
901,
64,
222
],
[
222,
24,
... | [
[
[
"Milnacipran",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ramucirumab"
]
],
[
[
"Milnacipran",
"{u} (Compound) resembles {v} (Compound)",
"Levomilnacipran"
],
[
"Levomilnacipran",
"{u} may ca... | Milnacipran (Compound) resembles Levomilnacipran (Compound) and Levo
Milnacipran may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Ramucirumab
Milnacipran may lead to a major life thre... |
DB06718 | DB09564 | 1,687 | 1,296 | [
"DDInter1709",
"DDInter930"
] | Stanozolol | Insulin degludec | Stanozolol is a synthetic anabolic steroid with therapeutic uses in treating hereditary angioedema. Stanozolol is derived from testosterone, and has been abused by several high profile professional athletes. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
1687,
24,
1296
]
],
[
[
1687,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
1687,
40,
155
],
[
155,
24,
1296
]
],
[
[
1687,
1,
1026
],
[
1026,... | [
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Stanozolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],
... | Stanozolol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Stanozolol (Compound) resembles Fluoxymesterone (Compound) and Fluoxymesterone may cause a moderate inte... |
DB00215 | DB09078 | 1,230 | 1,228 | [
"DDInter388",
"DDInter1036"
] | Citalopram | Lenvatinib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
1230,
25,
1228
]
],
[
[
1230,
23,
112
],
[
112,
23,
1228
]
],
[
[
1230,
25,
609
],
[
609,
24,
1228
]
],
[
[
1230,
24,
770
],
[
770,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronida... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Citalopram may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin ... |
DB00731 | DB00978 | 1,144 | 739 | [
"DDInter1269",
"DDInter1084"
] | Nateglinide | Lomefloxacin | Nateglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Nateglinide is an amino acid derivative that ... | Lomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well. | Major | 2 | [
[
[
1144,
25,
739
]
],
[
[
1144,
25,
945
],
[
945,
40,
739
]
],
[
[
1144,
64,
1176
],
[
1176,
1,
739
]
],
[
[
1144,
64,
1467
],
[
1467,
... | [
[
[
"Nateglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomefloxacin"
]
],
[
[
"Nateglinide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sparfloxacin"
],
[
"Sparfloxacin",
... | Nateglinide may lead to a major life threatening interaction when taken with Sparfloxacin and Sparfloxacin (Compound) resembles Lomefloxacin (Compound)
Nateglinide may lead to a major life threatening interaction when taken with Moxifloxacin and Moxifloxacin (Compound) resembles Lomefloxacin (Compound)
Nateglinide may ... |
DB08897 | DB09076 | 1,429 | 1,116 | [
"DDInter22",
"DDInter1899"
] | Aclidinium | Umeclidinium | Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD). It has a much higher propensity to bind to muscarinic receptors than nicotinic receptors. FDA approved on July 24, 2012. | Umeclidinium is a long-acting muscarinic antagonist (LAMA) used as a maintenance treatment for symptoms of chronic obstructive pulmonary disease (COPD). COPD is a progressive obstructive lung disease characterized by shortness of breath, cough, sputum production, and chronically poor airflow with a forced expiratory vo... | Moderate | 1 | [
[
[
1429,
24,
1116
]
],
[
[
1429,
63,
849
],
[
849,
24,
1116
]
],
[
[
1429,
74,
1415
],
[
1415,
24,
1116
]
],
[
[
1429,
24,
337
],
[
337,
... | [
[
[
"Aclidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Umeclidinium"
]
],
[
[
"Aclidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Aclidinium may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Umeclidinium
Aclidinium (Compound) resembles Tiotropium (Compound) and Aclidinium may cause a moderate interaction that cou... |
DB00341 | DB00434 | 1,242 | 13 | [
"DDInter343",
"DDInter459"
] | Cetirizine | Cyproheptadine | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms,. One of the most common uses for this drug is for a condition called _allerg... | Cyproheptadine is a potent competitive antagonist of both serotonin and histamine receptors. It is used primarily to treat allergic symptoms, though it is perhaps more notable for its use in appetite stimulation and its off-label use in the treatment of serotonin syndrome. | Moderate | 1 | [
[
[
1242,
24,
13
]
],
[
[
1242,
24,
104
],
[
104,
63,
13
]
],
[
[
1242,
24,
1302
],
[
1302,
24,
13
]
],
[
[
1242,
40,
465
],
[
465,
... | [
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyproheptadine"
]
],
[
[
"Cetirizine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Cyproheptadine
Cetirizine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline... |
DB00682 | DB14730 | 126 | 1,412 | [
"DDInter1951",
"DDInter264"
] | Warfarin | Calaspargase pegol | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Asparaginase is an important agent used to treat acute lymphoblastic leukemia (ALL) . Asparagine is incorporated into most proteins, and the synthesis of proteins is stopped when asparagine is absent, which inhibits RNA and DNA synthesis, resulting in a halt in cellular proliferation. This forms the basis of asparagina... | Moderate | 1 | [
[
[
126,
24,
1412
]
],
[
[
126,
25,
792
],
[
792,
24,
1412
]
],
[
[
126,
24,
250
],
[
250,
24,
1412
]
],
[
[
126,
63,
883
],
[
883,
... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calaspargase pegol"
]
],
[
[
"Warfarin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rivaroxaban"
],
[
"Rivar... | Warfarin may lead to a major life threatening interaction when taken with Rivaroxaban and Rivaroxaban may cause a moderate interaction that could exacerbate diseases when taken with Calaspargase pegol
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Blinatumomab and Blinatumomab ... |
DB00682 | DB01242 | 126 | 1,237 | [
"DDInter1951",
"DDInter410"
] | Warfarin | Clomipramine | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Moderate | 1 | [
[
[
126,
24,
1237
]
],
[
[
126,
24,
1164
],
[
1164,
1,
1237
]
],
[
[
126,
63,
21
],
[
21,
1,
1237
]
],
[
[
126,
6,
7950
],
[
7950,
4... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clomipramine"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trimipramine"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Clomipramine (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Amitriptyline and Amitriptyline (Compound) resembles Clomipramine (... |
DB01142 | DB06788 | 1,264 | 1,616 | [
"DDInter593",
"DDInter864"
] | Doxepin | Histrelin | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Moderate | 1 | [
[
[
1264,
24,
1616
]
],
[
[
1264,
62,
112
],
[
112,
23,
1616
]
],
[
[
1264,
63,
1664
],
[
1664,
24,
1616
]
],
[
[
1264,
24,
623
],
[
623,
... | [
[
[
"Doxepin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Histrelin"
]
],
[
[
"Doxepin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Doxepin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Doxepin may cause a moderate interaction that could exacerbate diseases when taken with Risperidone and Risperidon... |
DB00791 | DB14711 | 132 | 779 | [
"DDInter1902",
"DDInter1680"
] | Uracil mustard | Smallpox (Vaccinia) Vaccine, Live | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | The New York City Board of Health strain of _Vaccinia_ is a viral strain used as a component of some smallpox vaccinations. ACAM2000, a percutaneously administered smallpox vaccine that was approved by the FDA in 2007, contains live antigens of this strain. | Major | 2 | [
[
[
132,
25,
779
]
],
[
[
132,
64,
1064
],
[
1064,
25,
779
]
],
[
[
132,
25,
1377
],
[
1377,
25,
779
]
],
[
[
132,
24,
270
],
[
270,
... | [
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Smallpox (Vaccinia) Vaccine, Live"
]
],
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cladribine"
],
[
... | Uracil mustard may lead to a major life threatening interaction when taken with Cladribine and Cladribine may lead to a major life threatening interaction when taken with Smallpox (Vaccinia) Vaccine, Live
Uracil mustard may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may lea... |
DB00363 | DB09104 | 695 | 286 | [
"DDInter419",
"DDInter1118"
] | Clozapine | Magnesium hydroxide | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
695,
24,
286
]
],
[
[
695,
25,
820
],
[
820,
23,
286
]
],
[
[
695,
40,
1119
],
[
1119,
23,
286
]
],
[
[
695,
24,
401
],
[
401,
2... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Clozapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
],
[
"Al... | Clozapine may lead to a major life threatening interaction when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Clozapine (Compound) resembles Chlordiazepoxide (Compound) and Chlordiazepoxide may cause a minor interaction that can ... |
DB00804 | DB01359 | 1,507 | 729 | [
"DDInter543",
"DDInter1417"
] | Dicyclomine | Penbutolol | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Moderate | 1 | [
[
[
1507,
24,
729
]
],
[
[
1507,
63,
461
],
[
461,
1,
729
]
],
[
[
1507,
24,
699
],
[
699,
40,
729
]
],
[
[
1507,
21,
28698
],
[
28698,
... | [
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Penbutolol"
]
],
[
[
"Dicyclomine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Timolol"
],
[
... | Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Timolol and Timolol (Compound) resembles Penbutolol (Compound)
Dicyclomine may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol (Compound) resembles Penbutolol (Compound)
Dicyclomin... |
DB01105 | DB12010 | 222 | 214 | [
"DDInter1665",
"DDInter785"
] | Sibutramine | Fostamatinib | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
222,
24,
214
]
],
[
[
222,
62,
723
],
[
723,
24,
214
]
],
[
[
222,
24,
879
],
[
879,
24,
214
]
],
[
[
222,
64,
1373
],
[
1373,
2... | [
[
[
"Sibutramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Sibutramine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Aprepitant"
],
[
... | Sibutramine may cause a minor interaction that can limit clinical effects when taken with Aprepitant and Aprepitant may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Sibutramine may cause a moderate interaction that could exacerbate diseases when taken with Lumateperone and Lu... |
DB00399 | DB09078 | 963 | 1,228 | [
"DDInter1968",
"DDInter1036"
] | Zoledronic acid | Lenvatinib | Zoledronic acid, or CGP 42'446, is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors,... | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Moderate | 1 | [
[
[
963,
24,
1228
]
],
[
[
963,
24,
770
],
[
770,
24,
1228
]
],
[
[
963,
40,
641
],
[
641,
24,
1228
]
],
[
[
963,
1,
1199
],
[
1199,
... | [
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lenvatinib"
]
],
[
[
"Zoledronic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thalidomide"
... | Zoledronic acid may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide and Thalidomide may cause a moderate interaction that could exacerbate diseases when taken with Lenvatinib
Zoledronic acid (Compound) resembles Pamidronic acid (Compound) and Pamidronic acid may cause a moderate ... |
DB00836 | DB01244 | 543 | 762 | [
"DDInter1088",
"DDInter192"
] | Loperamide | Bepridil | Loperamide is an anti-diarrheal agent that is available as various over-the-counter products for treating diarrhea. The drug was first synthesized in 1969 and used medically in 1976. It is a highly lipophilic synthetic phenylpiperidine opioid that is structurally similar to opiate receptor agonists such as [diphenoxyla... | A long-acting, non selective, calcium channel blocker with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. It is no longer marketed in the United St... | Major | 2 | [
[
[
543,
25,
762
]
],
[
[
543,
1,
11264
],
[
11264,
40,
762
]
],
[
[
543,
24,
1376
],
[
1376,
24,
762
]
],
[
[
543,
1,
704
],
[
704,
... | [
[
[
"Loperamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bepridil"
]
],
[
[
"Loperamide",
"{u} (Compound) resembles {v} (Compound)",
"Diphenidol"
],
[
"Diphenidol",
"{u} (Compound) resembles {v} (Compound)"... | Loperamide (Compound) resembles Diphenidol (Compound) and Diphenidol (Compound) resembles Bepridil (Compound)
Loperamide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Bep... |
DB00475 | DB00682 | 1,119 | 126 | [
"DDInter355",
"DDInter1951"
] | Chlordiazepoxide | Warfarin | An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal. | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Minor | 0 | [
[
[
1119,
23,
126
]
],
[
[
1119,
24,
1376
],
[
1376,
40,
126
]
],
[
[
1119,
6,
8374
],
[
8374,
45,
126
]
],
[
[
1119,
24,
1074
],
[
1074,
... | [
[
[
"Chlordiazepoxide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Warfarin"
]
],
[
[
"Chlordiazepoxide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Chlordiazepoxide may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine (Compound) resembles Warfarin (Compound)
Chlordiazepoxide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Warfarin (Compound)
Chlordiazepoxide may cause a moderate interactio... |
DB00963 | DB09133 | 1,263 | 1,527 | [
"DDInter241",
"DDInter965"
] | Bromfenac | Iothalamic acid | Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool f... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
1263,
25,
1527
]
],
[
[
1263,
63,
91
],
[
91,
25,
1527
]
],
[
[
1263,
24,
848
],
[
848,
25,
1527
]
],
[
[
1263,
1,
24
],
[
24,
2... | [
[
[
"Bromfenac",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Bromfenac",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
"Vancomy... | Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may lead to a major life threatening interaction when taken with Iothalamic acid
Bromfenac may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen and Ibuprofen may lead ... |
DB00553 | DB09118 | 92 | 1,580 | [
"DDInter1177",
"DDInter1711"
] | Methoxsalen | Stiripentol | A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. | Stiripentol is an antiepileptic agent that is an aromatic allylic alcohol drug, which makes it structurally unique from other antiepileptic drugs.[A19740, A250825] The clinical development and marketing of stiripentol were first delayed due to the drug's potent inhibitory effects on hepatic cytochrome P450 (CYP) enzyme... | Moderate | 1 | [
[
[
92,
24,
1580
]
],
[
[
92,
63,
1195
],
[
1195,
24,
1580
]
],
[
[
92,
24,
820
],
[
820,
24,
1580
]
],
[
[
92,
24,
866
],
[
866,
25... | [
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Stiripentol"
]
],
[
[
"Methoxsalen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erlotinib"
],
[
... | Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Erlotinib and Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Stiripentol
Methoxsalen may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alim... |
DB09570 | DB12240 | 1,480 | 110 | [
"DDInter1002",
"DDInter1485"
] | Ixazomib | Polatuzumab vedotin | Ixazomib a second generation proteasome inhibitor (PI) and the first oral PI approved by the FDA in November 2015 for multiple myeloma treatment in combination with 2 other therapies (lenalidomide and dexamethasone) for patients who have received at least 1 prior therapy. It was found to have similar efficacy to bortez... | Polatuzumab vedotin is a CD79b-directed antibody-drug conjugate that delivers monomethyl auristatin E (MMAE), an anti-mitotic agent, to cancer cells. The drug consists of three components - a humanized immunoglobulin G1 (IgG1) monoclonal antibody specific for human CD79b (polatuzumab), MMAE, and protease-cleavable link... | Moderate | 1 | [
[
[
1480,
24,
110
]
],
[
[
1480,
64,
129
],
[
129,
23,
110
]
],
[
[
1480,
25,
913
],
[
913,
23,
110
]
],
[
[
1480,
63,
467
],
[
467,
... | [
[
[
"Ixazomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polatuzumab vedotin"
]
],
[
[
"Ixazomib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enz... | Ixazomib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Polatuzumab vedotin
Ixazomib may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause a mino... |
DB00067 | DB01169 | 317 | 57 | [
"DDInter1921",
"DDInter120"
] | Vasopressin | Arsenic trioxide | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | Arsenic trioxide is a chemotherapeutic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. In general, arsenic is known to be a naturally toxic substance capable of eliciting a variety of danger... | Major | 2 | [
[
[
317,
25,
57
]
],
[
[
317,
23,
112
],
[
112,
23,
57
]
],
[
[
317,
24,
480
],
[
480,
24,
57
]
],
[
[
317,
24,
144
],
[
144,
63,
... | [
[
[
"Vasopressin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Arsenic trioxide"
]
],
[
[
"Vasopressin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"M... | Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Arsenic trioxide
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Formoterol ... |
DB00627 | DB09054 | 265 | 384 | [
"DDInter1286",
"DDInter905"
] | Niacin | Idelalisib | Niacin is a B vitamin used to treat vitamin deficiencies as well as hyperlipidemia, dyslipidemia, hypertriglyceridemia, and to reduce the risk of myocardial infarctions.[L7550,L7553,L7556,L7559,L7562,L7565] | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
265,
24,
384
]
],
[
[
265,
63,
305
],
[
305,
24,
384
]
],
[
[
265,
24,
761
],
[
761,
24,
384
]
],
[
[
265,
25,
14
],
[
14,
24,
... | [
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Niacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Escherichia coli"
... | Niacin may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escherichia coli and Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib
Niacin may cause a moderate interaction that could exacerbate diseases when ta... |
DB00067 | DB00342 | 317 | 1,181 | [
"DDInter1921",
"DDInter1770"
] | Vasopressin | Terfenadine | Vasopressin (arginine-vasopressin or antidiuretic hormone) is a nonapeptide primarily produced in the hypothalamus that exhibits diverse physiological functions related to diuresis, hemodynamic modulation, and behaviour.[A110, A111, A112, A113, A228008] Vasopressin is very similar to oxytocin, differing in the third an... | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Moderate | 1 | [
[
[
317,
24,
1181
]
],
[
[
317,
23,
112
],
[
112,
62,
1181
]
],
[
[
317,
24,
1520
],
[
1520,
63,
1181
]
],
[
[
317,
25,
985
],
[
985,
... | [
[
[
"Vasopressin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terfenadine"
]
],
[
[
"Vasopressin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
... | Vasopressin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Terfenadine
Vasopressin may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and P... |
DB00734 | DB11827 | 1,664 | 433 | [
"DDInter1605",
"DDInter669"
] | Risperidone | Ertugliflozin | Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder. It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. ... | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
1664,
24,
433
]
],
[
[
1664,
24,
959
],
[
959,
24,
433
]
],
[
[
1664,
63,
521
],
[
521,
24,
433
]
],
[
[
1664,
1,
924
],
[
924,
... | [
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Risperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
... | Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Risperidone may cause a moderate interaction that could exacerbate diseases when taken with Goserelin and Gose... |
DB00308 | DB09078 | 347 | 1,228 | [
"DDInter901",
"DDInter1036"
] | Ibutilide | Lenvatinib | Ibutilide is a Class III antiarrhythmic agent available in intravenous formulations. It is indicated for the conversion of acute atrial flutter and recent onset atrial fibrillation to normal sinus rhythm (NSR). | Lenvatinib is a receptor tyrosine kinase (RTK) inhibitor that inhibits the kinase activities of vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4). Lenvatinib also inhibits other RTKs that have been implicated in pathogenic angiogenesis, tumor growth, and cancer progressi... | Major | 2 | [
[
[
347,
25,
1228
]
],
[
[
347,
23,
112
],
[
112,
23,
1228
]
],
[
[
347,
25,
609
],
[
609,
24,
1228
]
],
[
[
347,
24,
770
],
[
770,
... | [
[
[
"Ibutilide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lenvatinib"
]
],
[
[
"Ibutilide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronidazo... | Ibutilide may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lenvatinib
Ibutilide may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin ma... |
DB00647 | DB01218 | 675 | 1,493 | [
"DDInter528",
"DDInter852"
] | Dextropropoxyphene | Halofantrine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferen... | Major | 2 | [
[
[
675,
25,
1493
]
],
[
[
675,
6,
3486
],
[
3486,
45,
1493
]
],
[
[
675,
18,
2183
],
[
2183,
57,
1493
]
],
[
[
675,
21,
28810
],
[
28810,... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Halofantrine"
]
],
[
[
"Dextropropoxyphene",
"{u} (Compound) binds {v} (Gene)",
"CYP2C8"
],
[
"CYP2C8",
"{u} (Gene) is bound by {v} (Compound... | Dextropropoxyphene (Compound) binds CYP2C8 (Gene) and CYP2C8 (Gene) is bound by Halofantrine (Compound)
Dextropropoxyphene (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Halofantrine (Compound)
Dextropropoxyphene (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain... |
DB00365 | DB00907 | 839 | 290 | [
"DDInter842",
"DDInter427"
] | Grepafloxacin | Cocaine (topical) | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
839,
24,
290
]
],
[
[
839,
24,
629
],
[
629,
24,
290
]
],
[
[
839,
24,
1478
],
[
1478,
63,
290
]
],
[
[
839,
24,
455
],
[
455,
6... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cocaine"
]
],
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[
... | Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Cocaine
Grepafloxaci... |
DB08904 | DB14762 | 375 | 994 | [
"DDInter342",
"DDInter1602"
] | Certolizumab pegol | Risankizumab | Certolizumab pegol is a pegylated monoclonal antibody against the tumor necrosis factor-alpha (TNF-alpha). It is formed with a humanized Fab fragment of 50 kDa, from an IgG 1 isotype, fused to a 40 kDa polyethylene glycol moiety replacing the Fc antibody region. The absence of the Fc region was ideated to prevent compl... | Risankizumab is a fully humanized IgG1 monoclonal antibody (mAb) directed against interleukin 23 (IL-23). It gained its first global approval in Japan in March 2019, followed by approval in Canada, the US, and Europe in April 2019. Risankizumab is used to treat plaque psoriasis, psoriatic arthritis, and Crohn's disease... | Major | 2 | [
[
[
375,
25,
994
]
],
[
[
375,
23,
1114
],
[
1114,
23,
994
]
],
[
[
375,
62,
1461
],
[
1461,
23,
994
]
],
[
[
375,
64,
4
],
[
4,
24,... | [
[
[
"Certolizumab pegol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Risankizumab"
]
],
[
[
"Certolizumab pegol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[... | Certolizumab pegol may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Risankizumab
Certolizumab pegol may cause a minor interaction that can limit clinical effects when taken with Vitam... |
DB00631 | DB00987 | 372 | 1,224 | [
"DDInter405",
"DDInter460"
] | Clofarabine | Cytarabine | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant p... | Moderate | 1 | [
[
[
372,
35,
1224
]
],
[
[
372,
40,
1049
],
[
1049,
1,
1224
]
],
[
[
372,
1,
325
],
[
325,
40,
1224
]
],
[
[
372,
1,
1585
],
[
1585,
... | [
[
[
"Clofarabine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Clofarabine",
"{u} (Compound) resembles {v} (Compound)",
"Regadenoson"
],
[
... | Clofarabine (Compound) resembles Cytarabine (Compound) and
Clofarabine (Compound) resembles Regadenoson (Compound) and Regadenoson (Compound) resembles Cytarabine (Compound)
Clofarabine (Compound) resembles Nelarabine (Compound) and Nelarabine (Compound) resembles Cytarabine (Compound)
Clofarabine (Compound) resembles ... |
DB00344 | DB11730 | 1,302 | 351 | [
"DDInter1543",
"DDInter1588"
] | Protriptyline | Ribociclib | Protriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, protriptyline does not affect mood or arousal, but may ... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
1302,
25,
351
]
],
[
[
1302,
23,
112
],
[
112,
23,
351
]
],
[
[
1302,
25,
222
],
[
222,
23,
351
]
],
[
[
1302,
24,
283
],
[
283,
... | [
[
[
"Protriptyline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Protriptyline",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Met... | Protriptyline may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Protriptyline may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine ... |
DB06441 | DB08901 | 936 | 1,468 | [
"DDInter283",
"DDInter1492"
] | Cangrelor | Ponatinib | Cangrelor is an intravenous, direct-acting, reversible P2Y12 inhibitor for patients undergoing percutaneous coronary intervention (PCI) who have not been yet treated by oral P2Y12 inhibitors. An advantage Cangrelor provides over oral P2Y12 inhibitors (such as prasugrel, ticagrelor, and clopidogrel) is that it is an act... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Major | 2 | [
[
[
936,
25,
1468
]
],
[
[
936,
63,
1230
],
[
1230,
24,
1468
]
],
[
[
936,
64,
932
],
[
932,
24,
1468
]
],
[
[
936,
24,
637
],
[
637,
... | [
[
[
"Cangrelor",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ponatinib"
]
],
[
[
"Cangrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Citalopram"
],
[
"Citalopram",
... | Cangrelor may cause a moderate interaction that could exacerbate diseases when taken with Citalopram and Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Cangrelor may lead to a major life threatening interaction when taken with Mifepristone and Mifepristone may cause... |
DB00814 | DB00945 | 1,171 | 1,479 | [
"DDInter1143",
"DDInter20"
] | Meloxicam | Acetylsalicylic acid | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Also known as _Aspirin_, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial... | Moderate | 1 | [
[
[
1171,
24,
1479
]
],
[
[
1171,
1,
316
],
[
316,
40,
1479
]
],
[
[
1171,
6,
6017
],
[
6017,
45,
1479
]
],
[
[
1171,
10,
11666
],
[
11666... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
]
],
[
[
"Meloxicam",
"{u} (Compound) resembles {v} (Compound)",
"Nitazoxanide"
],
[
"Nitazoxanide",
"{u} (Compou... | Meloxicam (Compound) resembles Nitazoxanide (Compound) and Nitazoxanide (Compound) resembles Acetylsalicylic acid (Compound)
Meloxicam (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Acetylsalicylic acid (Compound)
Meloxicam (Compound) palliates osteoarthritis (Disease) and osteoarthritis (Disease) is pall... |
DB00501 | DB00708 | 752 | 1,454 | [
"DDInter380",
"DDInter1718"
] | Cimetidine | Sufentanil | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Sufentanil is an opioid analgesic that is used as an adjunct in anesthesia, in balanced anesthesia, and as a primary anesthetic agent. It is administered by the intravenous, epidural and sublingual routes. Also known as _Dsuvia_, the sublingual form is used for the management of acute pain in adults that is severe to w... | Moderate | 1 | [
[
[
752,
24,
1454
]
],
[
[
752,
24,
704
],
[
704,
40,
1454
]
],
[
[
752,
6,
8374
],
[
8374,
45,
1454
]
],
[
[
752,
21,
28658
],
[
28658,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sufentanil"
]
],
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fentanyl"
],
[
... | Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Fentanyl and Fentanyl (Compound) resembles Sufentanil (Compound)
Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Sufentanil (Compound)
Cimetidine (Compound) causes Vomiting (Side Effect) and Vomiting (Side... |
DB00476 | DB06209 | 109 | 256 | [
"DDInter608",
"DDInter1508"
] | Duloxetine | Prasugrel | Duloxetine is a dual serotonin and norepinephrine reuptake inhibitor.[label] It was originally discovered in 1993 and developed by Eli Lilly and Company as LY248686. Duloxetine first received approval from the FDA in August, 2004 as Cymbalta for the treatment of Major Depressive Disorder. It has since received approval... | Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversib... | Moderate | 1 | [
[
[
109,
24,
256
]
],
[
[
109,
21,
28681
],
[
28681,
60,
256
]
],
[
[
109,
23,
101
],
[
101,
23,
256
]
],
[
[
109,
24,
752
],
[
752,
... | [
[
[
"Duloxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prasugrel"
]
],
[
[
"Duloxetine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypersensitivity"
],
[
"Hypersensitivity",
"{u} (Side Ef... | Duloxetine (Compound) causes Hypersensitivity (Side Effect) and Hypersensitivity (Side Effect) is caused by Prasugrel (Compound)
Duloxetine may cause a minor interaction that can limit clinical effects when taken with Dexlansoprazole and Dexlansoprazole may cause a minor interaction that can limit clinical effects when... |
DB01064 | DB01235 | 1,148 | 1,191 | [
"DDInter987",
"DDInter1054"
] | Isoprenaline | Levodopa | Isoprenaline is a non-selective beta adrenergic receptor agonist indicated to treat heart block, Adams-Stokes attacks, bronchospasm in anesthesia, cadiac arrest, hypovolemic shocks, septic shock, hypoperfusion, congestive hear failure, and cardiogenic shock.[A15638,L33160] Isoprenaline research in the 1940s found that ... | Levodopa is a prodrug of dopamine that is administered to patients with Parkinson's due to its ability to cross the blood-brain barrier[Label]. Levodopa can be metabolised to dopamine on either side of the blood-brain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prev... | Moderate | 1 | [
[
[
1148,
35,
1191
]
],
[
[
1148,
24,
584
],
[
584,
1,
1191
]
],
[
[
1148,
1,
693
],
[
693,
40,
1191
]
],
[
[
1148,
40,
11434
],
[
11434,
... | [
[
[
"Isoprenaline",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levodopa"
]
],
[
[
"Isoprenaline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Isoprenaline (Compound) resembles Levodopa (Compound) and
Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Levonordefrin and Levonordefrin (Compound) resembles Levodopa (Compound)
Isoprenaline (Compound) resembles Isoetharine (Compound) and Isoetharine (Compound) resembles Le... |
DB12267 | DB14975 | 1,476 | 988 | [
"DDInter233",
"DDInter1949"
] | Brigatinib | Voxelotor | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Voxelotor is a novel hemoglobin S polymerization inhibitor for the treatment of sickle cell disease. This is a genetically inherited condition most prevalent in the Middle East, Africa, and certain parts of India. Sickle cell disease can lead to excruciating pain, stroke, infection, and various other complications aris... | Major | 2 | [
[
[
1476,
25,
988
]
],
[
[
1476,
24,
466
],
[
466,
23,
988
]
],
[
[
1476,
63,
629
],
[
629,
24,
988
]
],
[
[
1476,
25,
676
],
[
676,
... | [
[
[
"Brigatinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Voxelotor"
]
],
[
[
"Brigatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolutam... | Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Voxelotor
Brigatinib may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Siroli... |
DB00850 | DB08882 | 1,630 | 1,281 | [
"DDInter1432",
"DDInter1070"
] | Perphenazine | Linagliptin | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
1630,
24,
1281
]
],
[
[
1630,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
1630,
6,
8374
],
[
8374,
45,
1281
]
],
[
[
1630,
21,
29081
],
[
290... | [
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Perphenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
],
... | Perphenazine may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Perphenazine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Linagliptin (Compound)
Perphenazine (Compound) causes Angioedema (Side Effect) and ... |
DB01611 | DB06273 | 1,487 | 980 | [
"DDInter893",
"DDInter1824"
] | Hydroxychloroquine | Tocilizumab | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Moderate | 1 | [
[
[
1487,
24,
980
]
],
[
[
1487,
64,
494
],
[
494,
24,
980
]
],
[
[
1487,
63,
139
],
[
139,
24,
980
]
],
[
[
1487,
24,
309
],
[
309,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tocilizumab"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Disopyramide"
],
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Disopyramide and Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Tocilizumab
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and ... |
DB00845 | DB00938 | 1,490 | 455 | [
"DDInter406",
"DDInter1635"
] | Clofazimine | Salmeterol | Clofazimine is a highly lipophilic antimicrobial riminophenazine dye used in combination with other agents, such as [dapsone], for the treatment of leprosy. It was originally described in 1957 and was the prototypical riminophenazine dye - a bright-red dye that, in its clinical use, results in long-lasting discoloratio... | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Moderate | 1 | [
[
[
1490,
24,
455
]
],
[
[
1490,
24,
688
],
[
688,
63,
455
]
],
[
[
1490,
6,
8374
],
[
8374,
45,
455
]
],
[
[
1490,
21,
28722
],
[
28722,
... | [
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salmeterol"
]
],
[
[
"Clofazimine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Salbutamol"
],
[
... | Clofazimine may cause a moderate interaction that could exacerbate diseases when taken with Salbutamol and Salbutamol may cause a moderate interaction that could exacerbate diseases when taken with Salmeterol
Clofazimine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Salmeterol (Compound)
Clofazimine (Com... |
DB00872 | DB11978 | 1,080 | 124 | [
"DDInter438",
"DDInter822"
] | Conivaptan | Glasdegib | Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both isotypes of the vasopressin receptor (V1a and V2). | Glasdegib, also known as PF-04449913, is a small-molecule hedgehog signaling inhibitor selected under the group of benzimidazoles. In early research, benzimidazoles attracted large interest as they represented a class of inhibitors with low molecular weight, potent inhibitory activity, and lacking unstable functionalit... | Major | 2 | [
[
[
1080,
25,
124
]
],
[
[
1080,
25,
1135
],
[
1135,
23,
124
]
],
[
[
1080,
24,
466
],
[
466,
62,
124
]
],
[
[
1080,
24,
26
],
[
26,
... | [
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Glasdegib"
]
],
[
[
"Conivaptan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} may ... | Conivaptan may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Glasdegib
Conivaptan may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a... |
DB00333 | DB00619 | 576 | 1,419 | [
"DDInter1166",
"DDInter909"
] | Methadone | Imatinib | Methadone is a potent synthetic analgesic that works as a full µ-opioid receptor (MOR) agonist and N-methyl-d-aspartate (NMDA) receptor antagonist. As a full MOR agonist, methadone mimics the natural effects of the body's opioids, endorphins, and enkephalins through the release of neurotransmitters involved in pain tra... | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Moderate | 1 | [
[
[
576,
24,
1419
]
],
[
[
576,
6,
4973
],
[
4973,
45,
1419
]
],
[
[
576,
21,
28762
],
[
28762,
60,
1419
]
],
[
[
576,
24,
222
],
[
222,
... | [
[
[
"Methadone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
]
],
[
[
"Methadone",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
... | Methadone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Imatinib (Compound)
Methadone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Imatinib (Compound)
Methadone may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine ma... |
DB01033 | DB10276 | 328 | 1,624 | [
"DDInter1156",
"DDInter1623"
] | Mercaptopurine | Rotavirus vaccine | An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia. | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Major | 2 | [
[
[
328,
25,
1624
]
],
[
[
328,
63,
552
],
[
552,
25,
1624
]
],
[
[
328,
24,
1307
],
[
1307,
25,
1624
]
],
[
[
328,
25,
770
],
[
770,
... | [
[
[
"Mercaptopurine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rotavirus vaccine"
]
],
[
[
"Mercaptopurine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
],
[
... | Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may lead to a major life threatening interaction when taken with Rotavirus vaccine
Mercaptopurine may cause a moderate interaction that could exacerbate diseases when taken with Melphalan and Melphal... |
DB00191 | DB09564 | 73 | 1,296 | [
"DDInter1447",
"DDInter930"
] | Phentermine | Insulin degludec | Phentermine is a sympathomimetic amine anorectic agent and it was introduced in 1959 as part of an anti-obesity combination drug.[A174361, A174364] It is chemically related to amphetamine and it is commonly referred to as an atypical amphetamine. Phentermine has not been reported an addictive potential which allows thi... | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
73,
24,
1296
]
],
[
[
73,
24,
1411
],
[
1411,
24,
1296
]
],
[
[
73,
35,
280
],
[
280,
24,
1296
]
],
[
[
73,
25,
1230
],
[
1230,
... | [
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Phentermine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
],... | Phentermine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Phentermine (Compound) resembles Mephentermine (Compound) and Phentermine may cause a moderate interact... |
DB01166 | DB08868 | 477 | 1,011 | [
"DDInter379",
"DDInter737"
] | Cilostazol | Fingolimod | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
477,
25,
1011
]
],
[
[
477,
6,
12523
],
[
12523,
45,
1011
]
],
[
[
477,
21,
28892
],
[
28892,
60,
1011
]
],
[
[
477,
62,
1247
],
[
124... | [
[
[
"Cilostazol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Cilostazol",
"{u} (Compound) binds {v} (Gene)",
"CYP2D6"
],
[
"CYP2D6",
"{u} (Gene) is bound by {v} (Compound)",
"Fingoli... | Cilostazol (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Fingolimod (Compound)
Cilostazol (Compound) causes Cardiac arrest (Side Effect) and Cardiac arrest (Side Effect) is caused by Fingolimod (Compound)
Cilostazol may cause a minor interaction that can limit clinical effects when taken with Sulfamethox... |
DB01216 | DB12010 | 284 | 214 | [
"DDInter736",
"DDInter785"
] | Finasteride | Fostamatinib | Finasteride is a synthetic 4-azasteroid compound and specific inhibitor of steroid Type II 5α-reductase, which is an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). It works in a similar fashion as [dutasteride], which is another 5-alpha-reductase inhibitor, by exerting a... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
284,
24,
214
]
],
[
[
284,
63,
600
],
[
600,
24,
214
]
],
[
[
284,
24,
1654
],
[
1654,
63,
214
]
],
[
[
284,
1,
1561
],
[
1561,
... | [
[
[
"Finasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Finasteride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
... | Finasteride may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Finasteride may cause a moderate interaction that could exacerbate diseases when taken with Somapacitan and... |
DB01320 | DB06691 | 651 | 849 | [
"DDInter783",
"DDInter1155"
] | Fosphenytoin | Mepyramine | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
651,
24,
849
]
],
[
[
651,
63,
1594
],
[
1594,
24,
849
]
],
[
[
651,
40,
362
],
[
362,
24,
849
]
],
[
[
651,
24,
407
],
[
407,
6... | [
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Fosphenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
... | Fosphenytoin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Fosphenytoin (Compound) resembles Phenytoin (Compound) and Phenytoin may cause a moderate interaction that cou... |
DB00927 | DB11986 | 1,559 | 484 | [
"DDInter712",
"DDInter648"
] | Famotidine | Entrectinib | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
1559,
24,
484
]
],
[
[
1559,
23,
1247
],
[
1247,
23,
484
]
],
[
[
1559,
62,
112
],
[
112,
23,
484
]
],
[
[
1559,
24,
1539
],
[
1539,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Famotidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
... | Famotidine may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Famotidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole ... |
DB00188 | DB14444 | 168 | 151 | [
"DDInter222",
"DDInter924"
] | Bortezomib | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
168,
24,
151
]
],
[
[
168,
63,
66
],
[
66,
24,
151
]
],
[
[
168,
24,
134
],
[
134,
24,
151
]
],
[
[
168,
25,
375
],
[
375,
24,
... | [
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could e... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Bortezomib may cause a moderate inter... |
DB00787 | DB01043 | 387 | 108 | [
"DDInter25",
"DDInter1146"
] | Acyclovir | Memantine | Acyclovir is a nucleotide analog antiviral used to treat herpes simplex, _Varicella zoster_, herpes zoster, herpes labialis, and acute herpetic keratitis[L7303,L7315,L7318,L7321,L7324,L7327]. Acyclovir is generally used first line in the treatment of these viruses and some products are indicated for patients as young a... | Initially approved by the FDA in 2013, memantine is an N-methyl-D-aspartate (NMDA) receptor antagonist used in the management of Alzheimer's Disease (AD). It is different from many other Alzheimer's Disease medications, as it works by a different mechanism than the cholinesterase enzyme inhibitors normally employed in ... | Minor | 0 | [
[
[
387,
23,
108
]
],
[
[
387,
21,
28852
],
[
28852,
60,
108
]
],
[
[
387,
63,
352
],
[
352,
24,
108
]
],
[
[
387,
21,
28852
],
[
28852,
... | [
[
[
"Acyclovir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Memantine"
]
],
[
[
"Acyclovir",
"{u} (Compound) causes {v} (Side Effect)",
"Leukopenia"
],
[
"Leukopenia",
"{u} (Side Effect) is caused ... | Acyclovir (Compound) causes Leukopenia (Side Effect) and Leukopenia (Side Effect) is caused by Memantine (Compound)
Acyclovir may cause a moderate interaction that could exacerbate diseases when taken with Trospium and Trospium may cause a moderate interaction that could exacerbate diseases when taken with Memantine
Ac... |
DB00078 | DB14444 | 1,172 | 151 | [
"DDInter898",
"DDInter924"
] | Ibritumomab tiuxetan | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1172,
24,
151
]
],
[
[
1172,
24,
66
],
[
66,
24,
151
]
],
[
[
1172,
25,
1468
],
[
1468,
24,
151
]
],
[
[
1172,
64,
1057
],
[
1057,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a moderate inte... | Ibritumomab tiuxetan may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Ibritumomab tiuxetan may le... |
DB10276 | DB11760 | 1,624 | 119 | [
"DDInter1623",
"DDInter1742"
] | Rotavirus vaccine | Talazoparib | Rotavirus commonly infects children and infants causing severe diarrhea and vomiting leading to potentially fatal dehydration. Two rotavirus vaccines are available for the prevention of rotavirus gastroenteritis, Rotateq and Rotarix. Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains. Rotar... | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Major | 2 | [
[
[
1624,
25,
119
]
],
[
[
1624,
64,
66
],
[
66,
24,
119
]
],
[
[
1624,
25,
351
],
[
351,
24,
119
]
],
[
[
1624,
25,
1619
],
[
1619,
... | [
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Talazoparib"
]
],
[
[
"Rotavirus vaccine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Efalizumab"
],
[
"Efalizumab... | Rotavirus vaccine may lead to a major life threatening interaction when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Rotavirus vaccine may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause ... |
DB00342 | DB00358 | 1,181 | 1,010 | [
"DDInter1770",
"DDInter1140"
] | Terfenadine | Mefloquine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
1181,
24,
1010
]
],
[
[
1181,
23,
112
],
[
112,
62,
1010
]
],
[
[
1181,
24,
823
],
[
823,
63,
1010
]
],
[
[
1181,
63,
521
],
[
521,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Mefloquine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Triclabendazole a... |
DB00994 | DB01125 | 361 | 279 | [
"DDInter1277",
"DDInter98"
] | Neomycin | Anisindione | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Moderate | 1 | [
[
[
361,
24,
279
]
],
[
[
361,
63,
1647
],
[
1647,
23,
279
]
],
[
[
361,
24,
712
],
[
712,
62,
279
]
],
[
[
361,
63,
660
],
[
660,
2... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anisindione"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acarbose"
],
[
"... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Acarbose and Acarbose may cause a minor interaction that can limit clinical effects when taken with Anisindione
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsalazine may ... |
DB01611 | DB08883 | 1,487 | 1,597 | [
"DDInter893",
"DDInter1428"
] | Hydroxychloroquine | Perampanel | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning ... | Moderate | 1 | [
[
[
1487,
24,
1597
]
],
[
[
1487,
64,
609
],
[
609,
23,
1597
]
],
[
[
1487,
25,
868
],
[
868,
24,
1597
]
],
[
[
1487,
64,
1264
],
[
1264,
... | [
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perampanel"
]
],
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Clarithromycin"
],
... | Hydroxychloroquine may lead to a major life threatening interaction when taken with Clarithromycin and Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Perampanel
Hydroxychloroquine may lead to a major life threatening interaction when taken with Vemurafenib and Vemurafenib m... |
DB01579 | DB09564 | 341 | 1,296 | [
"DDInter1439",
"DDInter930"
] | Phendimetrazine | Insulin degludec | Phendimetrazine is a weight loss medication. Phendimetrazine is chemically related to amphetamines and is a Schedule III drug under the Convention on Psychotropic Substances and in the US since 1970. | Insulin degludec is an ultra-long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes.[A18561,A18562,A18563,A18564,A174934] Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide horm... | Moderate | 1 | [
[
[
341,
24,
1296
]
],
[
[
341,
63,
1411
],
[
1411,
24,
1296
]
],
[
[
341,
24,
659
],
[
659,
24,
1296
]
],
[
[
341,
64,
73
],
[
73,
... | [
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin degludec"
]
],
[
[
"Phendimetrazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide... | Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec
Phendimetrazine may cause a moderate interaction that could exacerbate diseases when taken with Vil... |
DB00334 | DB00539 | 867 | 11 | [
"DDInter1326",
"DDInter1837"
] | Olanzapine | Toremifene | Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent. The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug inte... | Toremifene is a selective estrogen receptor modulator (SERM) and a nonsteroidal antiestrogen used to treat estrogen receptor positive breast cancer. Like [tamoxifen], toremifene is part of the first-generation triphenylethylene derivative chemical class of SERMs. Toremifene possesses tissue-specific actions: it has est... | Moderate | 1 | [
[
[
867,
24,
11
]
],
[
[
867,
24,
1594
],
[
1594,
40,
11
]
],
[
[
867,
6,
4973
],
[
4973,
45,
11
]
],
[
[
867,
7,
2756
],
[
2756,
46... | [
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Toremifene"
]
],
[
[
"Olanzapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[
... | Olanzapine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine (Compound) resembles Toremifene (Compound)
Olanzapine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Toremifene (Compound)
Olanzapine (Compound) upregulates GHR (Gene) and GHR (Gene) is upreg... |
DB09082 | DB11730 | 659 | 351 | [
"DDInter1934",
"DDInter1588"
] | Vilanterol | Ribociclib | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
659,
25,
351
]
],
[
[
659,
63,
222
],
[
222,
23,
351
]
],
[
[
659,
63,
867
],
[
867,
24,
351
]
],
[
[
659,
62,
1486
],
[
1486,
2... | [
[
[
"Vilanterol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
],
[
"Sibutrami... | Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Sibutramine and Sibutramine may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Olanzapine and Olanza... |
DB00563 | DB00570 | 663 | 147 | [
"DDInter1174",
"DDInter1936"
] | Methotrexate | Vinblastine | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Moderate | 1 | [
[
[
663,
24,
147
]
],
[
[
663,
63,
134
],
[
134,
24,
147
]
],
[
[
663,
5,
11555
],
[
11555,
44,
147
]
],
[
[
663,
6,
5912
],
[
5912,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinblastine"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelbine"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Vinblastine
Methotrexate (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by ... |
DB00047 | DB11943 | 176 | 255 | [
"DDInter932",
"DDInter495"
] | Insulin glargine | Delafloxacin | Insulin glargine is a long-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas t... | Delafloxacin is a fluoroquinolone antibiotic which has been used in trials studying the treatment and basic science of Gonorrhea, Hepatic Impairment, Bacterial Skin Diseases, Skin Structure Infections, and Community Acquired Pneumonia, among others. It was approved in June 2017 under the trade name Baxdela for use in t... | Major | 2 | [
[
[
176,
25,
255
]
],
[
[
176,
24,
1479
],
[
1479,
24,
255
]
],
[
[
176,
24,
1385
],
[
1385,
63,
255
]
],
[
[
176,
24,
1411
],
[
1411,
... | [
[
[
"Insulin glargine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delafloxacin"
]
],
[
[
"Insulin glargine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Acetylsalicylic acid"
],... | Insulin glargine may cause a moderate interaction that could exacerbate diseases when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Delafloxacin
Insulin glargine may cause a moderate interaction that could exacerbate diseases whe... |
DB04855 | DB06788 | 540 | 1,616 | [
"DDInter602",
"DDInter864"
] | Dronedarone | Histrelin | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Histrelin is a gonadotropin-releasing hormone (GnRH) agonist that acts as a potent inhibitor of gonadotropin when administered as an implant delivering continuous therapeutic doses. This drug is a synthetic analog of naturally occurring GnRH with a higher potency. Histrelin implants are non-biodegradable, diffusion-con... | Major | 2 | [
[
[
540,
25,
1616
]
],
[
[
540,
62,
112
],
[
112,
23,
1616
]
],
[
[
540,
25,
1342
],
[
1342,
24,
1616
]
],
[
[
540,
64,
77
],
[
77,
... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Histrelin"
]
],
[
[
"Dronedarone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Dronedarone may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Histrelin
Dronedarone may lead to a major life threatening interaction when taken with Romidepsin and Romidepsin may cau... |
DB00414 | DB00738 | 590 | 485 | [
"DDInter16",
"DDInter1420"
] | Acetohexamide | Pentamidine | A sulfonylurea hypoglycemic agent that is metabolized in the liver to 1-hydrohexamide. Acetohexamide has been discontinued in the US market. | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Moderate | 1 | [
[
[
590,
24,
485
]
],
[
[
590,
24,
1247
],
[
1247,
62,
485
]
],
[
[
590,
24,
1450
],
[
1450,
63,
485
]
],
[
[
590,
63,
867
],
[
867,
... | [
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentamidine"
]
],
[
[
"Acetohexamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
... | Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Pentamidine
Acetohexamide may cause a moderate interaction that could exacerbate diseases when taken with Empa... |
DB00574 | DB09080 | 121 | 144 | [
"DDInter717",
"DDInter1331"
] | Fenfluramine | Olodaterol | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Olodaterol is a novel, long-acting beta2-adrenergic agonist (LABA) that exerts its pharmacological effect by binding and activating beta2-adrenergic receptors located primarily in the lungs. Beta2-adrenergic receptors are membrane-bound receptors that are normally activated by endogenous epinephrine whose signalling, v... | Moderate | 1 | [
[
[
121,
24,
144
]
],
[
[
121,
24,
1301
],
[
1301,
24,
144
]
],
[
[
121,
64,
534
],
[
534,
24,
144
]
],
[
[
121,
25,
1399
],
[
1399,
... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olodaterol"
]
],
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levacetylmethadol"
... | Fenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Levacetylmethadol and Levacetylmethadol may cause a moderate interaction that could exacerbate diseases when taken with Olodaterol
Fenfluramine may lead to a major life threatening interaction when taken with Tramadol and Trama... |
DB00620 | DB14409 | 175 | 1,129 | [
"DDInter1855",
"DDInter867"
] | Triamcinolone | Human adenovirus e serotype 4 strain cl-68578 antigen | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Human adenovirus e serotype 4 strain cl-68578 antigen is a vaccine. | Moderate | 1 | [
[
[
175,
24,
1129
]
],
[
[
175,
64,
1057
],
[
1057,
24,
1129
]
],
[
[
175,
24,
1683
],
[
1683,
24,
1129
]
],
[
[
175,
40,
251
],
[
251,
... | [
[
[
"Triamcinolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Human adenovirus e serotype 4 strain cl-68578 antigen"
]
],
[
[
"Triamcinolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Triamcinolone may lead to a major life threatening interaction when taken with Etanercept and Etanercept may cause a moderate interaction that could exacerbate diseases when taken with Human adenovirus e serotype 4 strain cl-68578 antigen
Triamcinolone may cause a moderate interaction that could exacerbate diseases whe... |
DB00358 | DB01138 | 1,010 | 804 | [
"DDInter1140",
"DDInter1726"
] | Mefloquine | Sulfinpyrazone | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Moderate | 1 | [
[
[
1010,
24,
804
]
],
[
[
1010,
24,
998
],
[
998,
1,
804
]
],
[
[
1010,
6,
4973
],
[
4973,
45,
804
]
],
[
[
1010,
63,
608
],
[
608,
... | [
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfinpyrazone"
]
],
[
[
"Mefloquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenylbutazone"
],
... | Mefloquine may cause a moderate interaction that could exacerbate diseases when taken with Phenylbutazone and Phenylbutazone (Compound) resembles Sulfinpyrazone (Compound)
Mefloquine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sulfinpyrazone (Compound)
Mefloquine may cause a moderate interaction that cou... |
DB09065 | DB15035 | 760 | 503 | [
"DDInter424",
"DDInter1959"
] | Cobicistat | Zanubrutinib | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
760,
25,
503
]
],
[
[
760,
25,
982
],
[
982,
24,
503
]
],
[
[
760,
63,
868
],
[
868,
24,
503
]
],
[
[
760,
24,
98
],
[
98,
24,
... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ivosidenib"
],
[
"Ivosidenib",
"{u}... | Cobicistat may lead to a major life threatening interaction when taken with Ivosidenib and Ivosidenib may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may ca... |
DB00574 | DB01238 | 121 | 673 | [
"DDInter717",
"DDInter118"
] | Fenfluramine | Aripiprazole | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
121,
24,
673
]
],
[
[
121,
25,
851
],
[
851,
1,
673
]
],
[
[
121,
25,
827
],
[
827,
40,
673
]
],
[
[
121,
25,
1039
],
[
1039,
24... | [
[
[
"Fenfluramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Fenfluramine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Nefazodone"
],
[
"Nefa... | Fenfluramine may lead to a major life threatening interaction when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Fenfluramine may lead to a major life threatening interaction when taken with Trazodone and Trazodone (Compound) resembles Aripiprazole (Compound)
Fenfluramine may lead to... |
DB00814 | DB04932 | 1,171 | 1,564 | [
"DDInter1143",
"DDInter491"
] | Meloxicam | Defibrotide | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
1171,
24,
1564
]
],
[
[
1171,
24,
1039
],
[
1039,
24,
1564
]
],
[
[
1171,
1,
1027
],
[
1027,
24,
1564
]
],
[
[
1171,
24,
738
],
[
738,... | [
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Meloxicam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
... | Meloxicam may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Defibrotide
Meloxicam (Compound) resembles Piroxicam (Compound) and Piroxicam may cause a moderate interaction tha... |
DB00397 | DB01089 | 1,466 | 1,340 | [
"DDInter1458",
"DDInter502"
] | Phenylpropanolamine | Deserpidine | Phenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes. | Deserpidine is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive properties that has been used for the control of high blood pressure and for the relief of psychotic behavior. | Moderate | 1 | [
[
[
1466,
24,
1340
]
],
[
[
1466,
63,
1245
],
[
1245,
40,
1340
]
],
[
[
1466,
35,
1445
],
[
1445,
24,
1340
]
],
[
[
1466,
24,
1411
],
[
14... | [
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deserpidine"
]
],
[
[
"Phenylpropanolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Reserpin... | Phenylpropanolamine may cause a moderate interaction that could exacerbate diseases when taken with Reserpine and Reserpine (Compound) resembles Deserpidine (Compound)
Phenylpropanolamine (Compound) resembles Pseudoephedrine (Compound) and Phenylpropanolamine may cause a moderate interaction that could exacerbate disea... |
DB00175 | DB12834 | 681 | 148 | [
"DDInter1509",
"DDInter1649"
] | Pravastatin | Secnidazole | Pravastatin is the 6-alpha-hydroxy acid form of [mevastatin]. Pravastatin was firstly approved in 1991 becoming the second available statin in the United States. It was the first statin administered as the active form and not as a prodrug. This drug was developed by Sankyo Co. Ltd.; however, the first approved pravasta... | Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent. It is structurally related to other 5-nitroimidazoles, including and , but displays improved oral absorption and a longer terminal elimination half-life than other drugs in this class. Secnidazole is selective against many anaerobic Gram-positive ... | Moderate | 1 | [
[
[
681,
24,
148
]
],
[
[
681,
24,
1593
],
[
1593,
24,
148
]
],
[
[
681,
63,
491
],
[
491,
24,
148
]
],
[
[
681,
35,
467
],
[
467,
2... | [
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secnidazole"
]
],
[
[
"Pravastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
],
[... | Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Secnidazole
Pravastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa... |
DB00530 | DB12010 | 1,195 | 214 | [
"DDInter667",
"DDInter785"
] | Erlotinib | Fostamatinib | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1195,
24,
214
]
],
[
[
1195,
24,
690
],
[
690,
24,
214
]
],
[
[
1195,
63,
322
],
[
322,
24,
214
]
],
[
[
1195,
23,
307
],
[
307,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifabutin"
],
[
... | Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Erlotinib may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubic... |
DB09065 | DB12674 | 760 | 975 | [
"DDInter424",
"DDInter1105"
] | Cobicistat | Lurbinectedin | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Lurbinectedin is a DNA alkylating agent that has been investigated in the treatment of a variety of cancers, including mesothelioma, chronic lymphocytic leukemia (CLL), breast cancer, and small-cell lung cancer (SCLC). It is a derivative of the marine-derived agent ecteinascidin ([trabectedin]), an anticancer agent fou... | Major | 2 | [
[
[
760,
25,
975
]
],
[
[
760,
25,
159
],
[
159,
63,
975
]
],
[
[
760,
24,
98
],
[
98,
24,
975
]
],
[
[
760,
64,
147
],
[
147,
24,
... | [
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lurbinectedin"
]
],
[
[
"Cobicistat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Larotrectinib"
],
[
"Larotrectinib",
... | Cobicistat may lead to a major life threatening interaction when taken with Larotrectinib and Larotrectinib may cause a moderate interaction that could exacerbate diseases when taken with Lurbinectedin
Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Somatrem and Somatrem may c... |
DB00215 | DB01067 | 1,230 | 959 | [
"DDInter388",
"DDInter826"
] | Citalopram | Glipizide | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
1230,
24,
959
]
],
[
[
1230,
24,
245
],
[
245,
40,
959
]
],
[
[
1230,
24,
1411
],
[
1411,
1,
959
]
],
[
[
1230,
6,
8374
],
[
8374,
... | [
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound... |
DB00959 | DB11640 | 1,486 | 1,267 | [
"DDInter1191",
"DDInter64"
] | Methylprednisolone | Amifampridine | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations . It was first discovered in Scotland in the 1970s and its clinical effectiveness for neuromuscul... | Moderate | 1 | [
[
[
1486,
24,
1267
]
],
[
[
1486,
40,
1220
],
[
1220,
24,
1267
]
],
[
[
1486,
24,
61
],
[
61,
24,
1267
]
],
[
[
1486,
63,
1648
],
[
1648,
... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amifampridine"
]
],
[
[
"Methylprednisolone",
"{u} (Compound) resembles {v} (Compound)",
"Dexamethasone"
],
[
"Dexamethasone",
... | Methylprednisolone (Compound) resembles Dexamethasone (Compound) and Dexamethasone may cause a moderate interaction that could exacerbate diseases when taken with Amifampridine
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Edrophonium and Edrophonium may cause a mode... |
DB00208 | DB01100 | 1,018 | 1,568 | [
"DDInter1804",
"DDInter1470"
] | Ticlopidine | Pimozide | Ticlopidine is an effective inhibitor of platelet aggregation. It is a prodrug that is metabolised to an active form, which blocks the ADP receptor that is involved in GPIIb/IIIa receptor activation leading to platelet aggregation. Ticlopidine is marketed under the brand name Ticlid and is indicated for patients who ca... | A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to haloperidol for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug ... | Moderate | 1 | [
[
[
1018,
24,
1568
]
],
[
[
1018,
6,
6365
],
[
6365,
45,
1568
]
],
[
[
1018,
21,
28921
],
[
28921,
60,
1568
]
],
[
[
1018,
23,
286
],
[
28... | [
[
[
"Ticlopidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pimozide"
]
],
[
[
"Ticlopidine",
"{u} (Compound) binds {v} (Gene)",
"CYP2E1"
],
[
"CYP2E1",
"{u} (Gene) is bound by {v} (Compound)",... | Ticlopidine (Compound) binds CYP2E1 (Gene) and CYP2E1 (Gene) is bound by Pimozide (Compound)
Ticlopidine (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Pimozide (Compound)
Ticlopidine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide an... |
DB01254 | DB04845 | 1,213 | 309 | [
"DDInter484",
"DDInter1001"
] | Dasatinib | Ixabepilone | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Ixabepilone is an epothilone B analog developed by Bristol-Myers Squibb as a cancer drug. It was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. Ixabepilone is administered through injection, and will be marketed under the trade name Ixempra. ... | Moderate | 1 | [
[
[
1213,
24,
309
]
],
[
[
1213,
18,
4161
],
[
4161,
45,
309
]
],
[
[
1213,
6,
8374
],
[
8374,
45,
309
]
],
[
[
1213,
21,
28987
],
[
28987... | [
[
[
"Dasatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ixabepilone"
]
],
[
[
"Dasatinib",
"{u} (Compound) downregulates {v} (Gene)",
"TUBB3"
],
[
"TUBB3",
"{u} (Gene) is bound by {v} (Compou... | Dasatinib (Compound) downregulates TUBB3 (Gene) and TUBB3 (Gene) is bound by Ixabepilone (Compound)
Dasatinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ixabepilone (Compound)
Dasatinib (Compound) causes Chills (Side Effect) and Chills (Side Effect) is caused by Ixabepilone (Compound)
Dasatinib may ca... |
DB08907 | DB14509 | 1,344 | 1,399 | [
"DDInter280",
"DDInter1081"
] | Canagliflozin | Lithium carbonate | Canagliflozin, also known as _Invokana_, is a sodium-glucose cotransporter 2 (SGLT2) inhibitor used in the management of type 2 diabetes mellitus along with lifestyle changes including diet and exercise [FDA label]. It was initially approved by the FDA in 2013 for the management of diabetes and later approved in 2018 f... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Moderate | 1 | [
[
[
1344,
24,
1399
]
],
[
[
1344,
63,
874
],
[
874,
23,
1399
]
],
[
[
1344,
63,
820
],
[
820,
24,
1399
]
],
[
[
1344,
24,
144
],
[
144,
... | [
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Canagliflozin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epinephrine"
... | Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Epinephrine and Epinephrine may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Canagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Alimemaz... |
DB00860 | DB10795 | 891 | 221 | [
"DDInter1513",
"DDInter1486"
] | Prednisolone | Poliovirus type 1 antigen (formaldehyde inactivated) | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Poliovirus type 1 antigen is a suspension of poliovirus Type 1 (Mahoney) used in the active immunization of infants (as young as 6 weeks of age), children, and adults for the prevention of poliomyelitis caused by poliovirus Type 1. The vaccine contains purified and inactivated poliovirus type 1 that were grown from a c... | Moderate | 1 | [
[
[
891,
24,
221
]
],
[
[
891,
64,
581
],
[
581,
24,
221
]
],
[
[
891,
63,
599
],
[
599,
24,
221
]
],
[
[
891,
1,
1486
],
[
1486,
24... | [
[
[
"Prednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Poliovirus type 1 antigen (formaldehyde inactivated)"
]
],
[
[
"Prednisolone",
"{u} may lead to a major life threatening interaction when taken with {v}",
... | Prednisolone may lead to a major life threatening interaction when taken with Infliximab and Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Poliovirus type 1 antigen (formaldehyde inactivated)
Prednisolone may cause a moderate interaction that could exacerbate diseases when t... |
DB00078 | DB00682 | 1,172 | 126 | [
"DDInter898",
"DDInter1951"
] | Ibritumomab tiuxetan | Warfarin | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Major | 2 | [
[
[
1172,
25,
126
]
],
[
[
1172,
23,
944
],
[
944,
62,
126
]
],
[
[
1172,
25,
477
],
[
477,
62,
126
]
],
[
[
1172,
24,
557
],
[
557,
... | [
[
[
"Ibritumomab tiuxetan",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Warfarin"
]
],
[
[
"Ibritumomab tiuxetan",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Chamomile"
],
[
... | Ibritumomab tiuxetan may cause a minor interaction that can limit clinical effects when taken with Chamomile and Chamomile may cause a minor interaction that can limit clinical effects when taken with Warfarin
Ibritumomab tiuxetan may lead to a major life threatening interaction when taken with Cilostazol and Cilostazo... |
DB00193 | DB01233 | 534 | 1,311 | [
"DDInter1841",
"DDInter1197"
] | Tramadol | Metoclopramide | Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to [codeine] and [morphine]. Due to its good tolerability profile and multimodal mechanism of action, tramadol is generally considered a lower-risk opioid option for the treatmen... | Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system. Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition... | Major | 2 | [
[
[
534,
25,
1311
]
],
[
[
534,
24,
1151
],
[
1151,
40,
1311
]
],
[
[
534,
25,
1425
],
[
1425,
40,
1311
]
],
[
[
534,
6,
12523
],
[
12523,... | [
[
[
"Tramadol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Metoclopramide"
]
],
[
[
"Tramadol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sunitinib"
],
[
"Sunitinib",... | Tramadol may cause a moderate interaction that could exacerbate diseases when taken with Sunitinib and Sunitinib (Compound) resembles Metoclopramide (Compound)
Tramadol may lead to a major life threatening interaction when taken with Cisapride and Cisapride (Compound) resembles Metoclopramide (Compound)
Tramadol (Compo... |
DB00031 | DB00574 | 20 | 121 | [
"DDInter1764",
"DDInter717"
] | Tenecteplase | Fenfluramine | Tenecteplase is a tissue plasminogen activator (tPA) developed from modifications of natural human tPA complementary DNA (cDNA). It is a 527 amino acid with a substitution of threonine 103 with asparagine and substitution of asparagine 117 with glutamine within the kringle 1 domain, and a tetra-alanine substitution at ... | Dravet syndrome is a pediatric encephalopathy that typically manifests within the first year of life following exposure to elevated temperatures. It is characterized by recurrent pharmacoresistant seizures, which increase in frequency and severity with disease progression. Concomitantly with these seizures, patients ty... | Moderate | 1 | [
[
[
20,
24,
121
]
],
[
[
20,
25,
366
],
[
366,
24,
121
]
],
[
[
20,
24,
24
],
[
24,
24,
121
]
],
[
[
20,
24,
958
],
[
958,
63,
... | [
[
[
"Tenecteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fenfluramine"
]
],
[
[
"Tenecteplase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eptifibatide"
],
[
"Ep... | Tenecteplase may lead to a major life threatening interaction when taken with Eptifibatide and Eptifibatide may cause a moderate interaction that could exacerbate diseases when taken with Fenfluramine
Tenecteplase may cause a moderate interaction that could exacerbate diseases when taken with Tolmetin and Tolmetin may ... |
DB00544 | DB00987 | 970 | 1,224 | [
"DDInter757",
"DDInter461"
] | Fluorouracil | Cytarabine (liposomal) | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Cytarabine can cause developmental toxicity according to an independent committee of scientific and health experts. | Moderate | 1 | [
[
[
970,
24,
1224
]
],
[
[
970,
6,
6882
],
[
6882,
45,
1224
]
],
[
[
970,
7,
15855
],
[
15855,
46,
1224
]
],
[
[
970,
54,
19218
],
[
19218... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cytarabine"
]
],
[
[
"Fluorouracil",
"{u} (Compound) binds {v} (Gene)",
"SLC29A1"
],
[
"SLC29A1",
"{u} (Gene) is bound by {v} (Compo... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Cytarabine
Fluorouracil (Compound) binds SLC29A1 (Gene) and SLC29A1 (Gene) is bound by Cytarabine (Compound)
Fluorouracil (Compound) upregulates SESN1 (Gene) and SESN1 (Gene) is upregulated by Cytarabine (Compound)
Fluorouracil... |
DB00371 | DB00486 | 1,050 | 1,614 | [
"DDInter1154",
"DDInter1253"
] | Meprobamate | Nabilone | A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (... | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
1050,
24,
1614
]
],
[
[
1050,
24,
530
],
[
530,
1,
1614
]
],
[
[
1050,
21,
28789
],
[
28789,
60,
1614
]
],
[
[
1050,
24,
999
],
[
999,... | [
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Meprobamate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
[
... | Meprobamate may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Meprobamate (Compound) causes Loss of consciousness (Side Effect) and Loss of consciousness (Side Effect) is caused by Nabilone (Compound)
Meprobamate may cause ... |
DB01075 | DB01105 | 1,376 | 222 | [
"DDInter569",
"DDInter1665"
] | Diphenhydramine | Sibutramine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | Sibutramine (trade name Meridia in the USA, Reductil in Europe and other countries), usually as sibutramide hydrochloride monohydrate, is an orally administered agent for the treatment of obesity. It is a centrally acting stimulant chemically related to amphetamines thus it is classified as a Schedule IV controlled sub... | Moderate | 1 | [
[
[
1376,
24,
222
]
],
[
[
1376,
21,
28698
],
[
28698,
60,
222
]
],
[
[
1376,
63,
847
],
[
847,
23,
222
]
],
[
[
1376,
24,
1339
],
[
1339,... | [
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sibutramine"
]
],
[
[
"Diphenhydramine",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect... | Diphenhydramine (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Sibutramine (Compound)
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine may cause a minor interaction that can limit clinical effects when taken wit... |
DB00862 | DB08820 | 1,005 | 1,478 | [
"DDInter1918",
"DDInter997"
] | Vardenafil | Ivacaftor | Vardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction.[L45563,L45568] During sexual stimulation, nitric oxide (NO) is released from nerve endings and endothelial cells in the corpus cavernosum, ... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
1005,
24,
1478
]
],
[
[
1005,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
1005,
21,
29221
],
[
29221,
60,
1478
]
],
[
[
1005,
63,
543
],
[
54... | [
[
[
"Vardenafil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Vardenafil",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Vardenafil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Vardenafil (Compound) causes Infestation (Side Effect) and Infestation (Side Effect) is caused by Ivacaftor (Compound)
Vardenafil may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Lo... |
DB00305 | DB06688 | 377 | 1,430 | [
"DDInter1232",
"DDInter1677"
] | Mitomycin | Sipuleucel-T | Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of _Streptomyces caespitosus_.[L12867,A193419] It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of th... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
377,
24,
1430
]
],
[
[
377,
24,
51
],
[
51,
24,
1430
]
],
[
[
377,
25,
676
],
[
676,
63,
1430
]
],
[
[
377,
24,
713
],
[
713,
63... | [
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Mitomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
[
... | Mitomycin may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Mitomycin may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib ma... |
DB00242 | DB00250 | 1,064 | 10 | [
"DDInter392",
"DDInter475"
] | Cladribine | Dapsone | An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Major | 2 | [
[
[
1064,
25,
10
]
],
[
[
1064,
7,
7720
],
[
7720,
45,
10
]
],
[
[
1064,
21,
28746
],
[
28746,
60,
10
]
],
[
[
1064,
24,
463
],
[
463,
... | [
[
[
"Cladribine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dapsone"
]
],
[
[
"Cladribine",
"{u} (Compound) upregulates {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is bound by {v} (Compound)",
"Dapson... | Cladribine (Compound) upregulates PTGS2 (Gene) and PTGS2 (Gene) is bound by Dapsone (Compound)
Cladribine (Compound) causes Erythema (Side Effect) and Erythema (Side Effect) is caused by Dapsone (Compound)
Cladribine may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampic... |
DB01114 | DB01168 | 272 | 1,053 | [
"DDInter362",
"DDInter1526"
] | Chlorpheniramine | Procarbazine | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. | Moderate | 1 | [
[
[
272,
24,
1053
]
],
[
[
272,
21,
28762
],
[
28762,
60,
1053
]
],
[
[
272,
24,
9
],
[
9,
63,
1053
]
],
[
[
272,
74,
100
],
[
100,
... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Procarbazine"
]
],
[
[
"Chlorpheniramine",
"{u} (Compound) causes {v} (Side Effect)",
"Headache"
],
[
"Headache",
"{u} (Side Eff... | Chlorpheniramine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Procarbazine (Compound)
Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Methotrimeprazine and Methotrimeprazine may cause a moderate interaction that could exacerbate diseas... |
DB01276 | DB15066 | 123 | 445 | [
"DDInter706",
"DDInter821"
] | Exenatide | Givosiran | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Moderate | 1 | [
[
[
123,
24,
445
]
],
[
[
123,
63,
1039
],
[
1039,
24,
445
]
],
[
[
123,
24,
850
],
[
850,
24,
445
]
],
[
[
123,
63,
629
],
[
629,
2... | [
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Givosiran"
]
],
[
[
"Exenatide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
],
[
... | Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine and Dexfenfluramine may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Exenatide may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab ve... |
DB00681 | DB15066 | 1,287 | 445 | [
"DDInter85",
"DDInter821"
] | Amphotericin B | Givosiran | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Givosiran is a small interfering RNA (siRNA) directed towards 5-aminolevulinic acid synthase, a critical enzyme in the heme biosynthesis pathway. It is manufactured by Alnylam Pharmaceuticals and was first approved for use in the United States in November 2019 for the treatment of adults with acute hepatic porphyria, a... | Moderate | 1 | [
[
[
1287,
24,
445
]
],
[
[
1287,
63,
1555
],
[
1555,
24,
445
]
],
[
[
1287,
24,
1272
],
[
1272,
24,
445
]
],
[
[
1287,
25,
1211
],
[
1211,... | [
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Givosiran"
]
],
[
[
"Amphotericin B",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
... | Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Givosiran
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Flucytosine ... |
DB00379 | DB11963 | 143 | 1,045 | [
"DDInter1206",
"DDInter465"
] | Mexiletine | Dacomitinib | Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties. | Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was devel... | Moderate | 1 | [
[
[
143,
24,
1045
]
],
[
[
143,
24,
187
],
[
187,
24,
1045
]
],
[
[
143,
24,
1670
],
[
1670,
25,
1045
]
],
[
[
143,
24,
187
],
[
187,
... | [
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dacomitinib"
]
],
[
[
"Mexiletine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
],
[
... | Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Pirfenidone and Pirfenidone may cause a moderate interaction that could exacerbate diseases when taken with Dacomitinib
Mexiletine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat and Eli... |
DB00418 | DB01234 | 536 | 1,220 | [
"DDInter1650",
"DDInter513"
] | Secobarbital | Dexamethasone | Secobarbital (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom. | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Moderate | 1 | [
[
[
536,
24,
1220
]
],
[
[
536,
24,
870
],
[
870,
1,
1220
]
],
[
[
536,
24,
175
],
[
175,
40,
1220
]
],
[
[
536,
6,
6017
],
[
6017,
... | [
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]
],
[
[
"Secobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
... | Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Dexamethasone (Compound)
Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles... |
DB00773 | DB06636 | 896 | 1,623 | [
"DDInter702",
"DDInter980"
] | Etoposide | Isavuconazonium | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Isavuconazonium is a second-generation triazole antifungal approved on March 6, 2015 by the FDA and July 2015 by the EMA for the treatment of adults with invasive aspergillosis and invasive mucormycosis, marketed by Astellas under the brand Cresemba. It is the prodrug form of isavuconazole, the active moiety, and it is... | Moderate | 1 | [
[
[
896,
24,
1623
]
],
[
[
896,
63,
1419
],
[
1419,
24,
1623
]
],
[
[
896,
24,
309
],
[
309,
24,
1623
]
],
[
[
896,
24,
1593
],
[
1593,
... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isavuconazonium"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Isavuconazonium
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Ixabepilone and Ixabep... |
DB00250 | DB09420 | 10 | 1,074 | [
"DDInter475",
"DDInter953"
] | Dapsone | Iodide I-123 | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect t... | Moderate | 1 | [
[
[
10,
24,
1074
]
],
[
[
10,
35,
161
],
[
161,
24,
1074
]
],
[
[
10,
1,
1247
],
[
1247,
24,
1074
]
],
[
[
10,
24,
1487
],
[
1487,
2... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-123"
]
],
[
[
"Dapsone",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with ... | Dapsone (Compound) resembles Sulfadiazine (Compound) and Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-123
Dapsone (Compound) resembles Sulfamethoxazole (Compo... |
DB00420 | DB09045 | 508 | 52 | [
"DDInter1532",
"DDInter607"
] | Promazine | Dulaglutide | A phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic. It is currently not approved for use in the United States. | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
508,
24,
52
]
],
[
[
508,
24,
170
],
[
170,
23,
52
]
],
[
[
508,
24,
609
],
[
609,
24,
52
]
],
[
[
508,
63,
73
],
[
73,
24,
... | [
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Promazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
[
... | Promazine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Promazine may cause a moderate interaction that could exacerbate diseases when taken with Clarithromycin and Cla... |
DB00381 | DB00902 | 376 | 104 | [
"DDInter79",
"DDInter1168"
] | Amlodipine | Methdilazine | Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
376,
24,
104
]
],
[
[
376,
24,
820
],
[
820,
1,
104
]
],
[
[
376,
24,
401
],
[
401,
63,
104
]
],
[
[
376,
1,
1081
],
[
1081,
24,... | [
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Amlodipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
[... | Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Amlodipine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction th... |
DB00317 | DB01232 | 883 | 1,327 | [
"DDInter810",
"DDInter1640"
] | Gefitinib | Saquinavir | Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Moderate | 1 | [
[
[
883,
24,
1327
]
],
[
[
883,
63,
798
],
[
798,
40,
1327
]
],
[
[
883,
24,
915
],
[
915,
40,
1327
]
],
[
[
883,
6,
10215
],
[
10215,
... | [
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saquinavir"
]
],
[
[
"Gefitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
... | Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Gefitinib may cause a moderate interaction that could exacerbate diseases when taken with Atazanavir and Atazanavir (Compound) resembles Saquinavir (Compound)
Ge... |
DB01242 | DB06605 | 1,237 | 1,409 | [
"DDInter410",
"DDInter108"
] | Clomipramine | Apixaban | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Moderate | 1 | [
[
[
1237,
24,
1409
]
],
[
[
1237,
6,
10215
],
[
10215,
45,
1409
]
],
[
[
1237,
21,
28787
],
[
28787,
60,
1409
]
],
[
[
1237,
24,
1670
],
[
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Apixaban"
]
],
[
[
"Clomipramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compoun... | Clomipramine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Apixaban (Compound)
Clomipramine (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Apixaban (Compound)
Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Eliglustat an... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.