drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB01268 | DB08827 | 1,151 | 990 | [
"DDInter1731",
"DDInter1085"
] | Sunitinib | Lomitapide | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Major | 2 | [
[
[
1151,
25,
990
]
],
[
[
1151,
63,
1080
],
[
1080,
1,
990
]
],
[
[
1151,
6,
8374
],
[
8374,
45,
990
]
],
[
[
1151,
21,
28903
],
[
28903,... | [
[
[
"Sunitinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lomitapide"
]
],
[
[
"Sunitinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Conivaptan"
],
[
"Conivaptan",... | Sunitinib may cause a moderate interaction that could exacerbate diseases when taken with Conivaptan and Conivaptan (Compound) resembles Lomitapide (Compound)
Sunitinib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lomitapide (Compound)
Sunitinib (Compound) causes Dry skin (Side Effect) and Dry skin (Sid... |
DB00081 | DB00465 | 273 | 886 | [
"DDInter1838",
"DDInter1011"
] | Tositumomab | Ketorolac (ophthalmic) | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Ketorolac is a racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used... | Moderate | 1 | [
[
[
273,
37,
886
]
],
[
[
273,
24,
282
],
[
282,
40,
886
]
],
[
[
273,
25,
24
],
[
24,
40,
886
]
],
[
[
273,
64,
20
],
[
20,
24,
... | [
[
[
"Tositumomab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v} and {u} may lead to a major life threatening interaction when taken with {v}",
"Ketorolac"
]
],
[
[
"Tositumomab",
"{u} may cause a moderate interaction that coul... | Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Ketorolac and Tositumomab may lead to a major life threatening interaction when taken with Ketorolac
Tositumomab may cause a moderate interaction that could exacerbate diseases when taken with Nepafenac and Nepafenac (Compound) ... |
DB09082 | DB14754 | 659 | 1,663 | [
"DDInter1934",
"DDInter1697"
] | Vilanterol | Solriamfetol | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apnea[FDA Label]. Solriamfetol was given FDA approval in 2019[FDA Label]. | Moderate | 1 | [
[
[
659,
24,
1663
]
],
[
[
659,
63,
1674
],
[
1674,
24,
1663
]
],
[
[
659,
63,
1053
],
[
1053,
25,
1663
]
],
[
[
659,
24,
1629
],
[
1629,
... | [
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Solriamfetol"
]
],
[
[
"Vilanterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
],
... | Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Orciprenaline and Orciprenaline may cause a moderate interaction that could exacerbate diseases when taken with Solriamfetol
Vilanterol may cause a moderate interaction that could exacerbate diseases when taken with Procarbazine ... |
DB00022 | DB00911 | 268 | 458 | [
"DDInter1408",
"DDInter1811"
] | Peginterferon alfa-2b | Tinidazole | Peginterferon alfa-2b is a form of recombinant interferon used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most co... | A nitroimidazole antitrichomonal agent effective against _Trichomonas vaginalis_, _Entamoeba histolytica_, and _Giardia lamblia_ infections. | Moderate | 1 | [
[
[
268,
24,
458
]
],
[
[
268,
24,
112
],
[
112,
1,
458
]
],
[
[
268,
24,
238
],
[
238,
24,
458
]
],
[
[
268,
24,
310
],
[
310,
63,
... | [
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tinidazole"
]
],
[
[
"Peginterferon alfa-2b",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metro... | Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole (Compound) resembles Tinidazole (Compound)
Peginterferon alfa-2b may cause a moderate interaction that could exacerbate diseases when taken with Ethambutol and Ethambutol may cause a mod... |
DB04946 | DB13928 | 924 | 1,385 | [
"DDInter907",
"DDInter1660"
] | Iloperidone | Semaglutide | Iloperidone is an atypical antipsychotic for the treatment of schizophrenia symptoms. Hoechst Marion Roussel Inc. researched the drug until May 1996. In June 1997 they gave the research rights to Titan Pharmaceuticals, who gave the worldwide development, manufacturing, and marketing rights to Novartis in August 1998. O... | Semaglutide is a glucagon-like peptide 1 (GLP-1) analog used to manage type 2 diabetes along with lifestyle changes, such as dietary restrictions and increased physical activity.[A31421,L8681] Other members of this drug class include [Exenatide] and [Liraglutide]. Semaglutide was developed by Novo Nordisk and approved ... | Moderate | 1 | [
[
[
924,
24,
1385
]
],
[
[
924,
25,
1154
],
[
1154,
24,
1385
]
],
[
[
924,
63,
1144
],
[
1144,
24,
1385
]
],
[
[
924,
64,
1148
],
[
1148,
... | [
[
[
"Iloperidone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Semaglutide"
]
],
[
[
"Iloperidone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pasireotide"
],
[
"Pasire... | Iloperidone may lead to a major life threatening interaction when taken with Pasireotide and Pasireotide may cause a moderate interaction that could exacerbate diseases when taken with Semaglutide
Iloperidone may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and Nateglinide may... |
DB01042 | DB09498 | 1,307 | 810 | [
"DDInter1144",
"DDInter1715"
] | Melphalan | Strontium chloride Sr-89 | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
1307,
24,
810
]
],
[
[
1307,
63,
552
],
[
552,
24,
810
]
],
[
[
1307,
24,
60
],
[
60,
24,
810
]
],
[
[
1307,
24,
385
],
[
385,
6... | [
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
... | Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Capecitab... |
DB00681 | DB00877 | 1,287 | 629 | [
"DDInter85",
"DDInter1678"
] | Amphotericin B | Sirolimus | Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphot... | Sirolimus, also known as rapamycin, is a macrocyclic lactone antibiotic produced by bacteria _Streptomyces hygroscopicus_, which was isolated from the soil of the Vai Atari region of Rapa Nui (Easter Island). It was first isolated and identified as an antifungal agent with potent anticandida activity; however, after it... | Major | 2 | [
[
[
1287,
25,
629
]
],
[
[
1287,
21,
29203
],
[
29203,
60,
629
]
],
[
[
1287,
63,
1215
],
[
1215,
24,
629
]
],
[
[
1287,
25,
1301
],
[
130... | [
[
[
"Amphotericin B",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sirolimus"
]
],
[
[
"Amphotericin B",
"{u} (Compound) causes {v} (Side Effect)",
"Aspartate aminotransferase increased"
],
[
"Aspartate aminotransferas... | Amphotericin B (Compound) causes Aspartate aminotransferase increased (Side Effect) and Aspartate aminotransferase increased (Side Effect) is caused by Sirolimus (Compound)
Amphotericin B may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole may cause a moderate i... |
DB00436 | DB00804 | 323 | 1,507 | [
"DDInter179",
"DDInter543"
] | Bendroflumethiazide | Dicyclomine | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Dicyclomine is a muscarinic M1, M3, and M2 receptor antagonist as well as a non-competitive inhibitor of histamine and bradykinin used to treat spasms of the intestines seen in functional bowel disorder and irritable bowel syndrome.[A6556,A182555,A234659,L7967] Though it is commonly prescribed, its recommendation may h... | Minor | 0 | [
[
[
323,
23,
1507
]
],
[
[
323,
21,
29209
],
[
29209,
60,
1507
]
],
[
[
323,
40,
674
],
[
674,
62,
1507
]
],
[
[
323,
40,
1014
],
[
1014,
... | [
[
[
"Bendroflumethiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Dicyclomine"
]
],
[
[
"Bendroflumethiazide",
"{u} (Compound) causes {v} (Side Effect)",
"Anorexia"
],
[
"Anorexia",
"{u} (Side ... | Bendroflumethiazide (Compound) causes Anorexia (Side Effect) and Anorexia (Side Effect) is caused by Dicyclomine (Compound)
Bendroflumethiazide (Compound) resembles Trichlormethiazide (Compound) and Trichlormethiazide may cause a minor interaction that can limit clinical effects when taken with Dicyclomine
Bendroflumet... |
DB00295 | DB00934 | 475 | 413 | [
"DDInter1244",
"DDInter1124"
] | Morphine | Maprotiline | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Moderate | 1 | [
[
[
475,
24,
413
]
],
[
[
475,
24,
1302
],
[
1302,
40,
413
]
],
[
[
475,
6,
4973
],
[
4973,
45,
413
]
],
[
[
475,
21,
28880
],
[
28880,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Maprotiline"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protriptyline"
],
[
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Protriptyline and Protriptyline (Compound) resembles Maprotiline (Compound)
Morphine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Maprotiline (Compound)
Morphine (Compound) causes Angiopathy (Side Effect) and Angiopat... |
DB00254 | DB00713 | 964 | 1,138 | [
"DDInter598",
"DDInter1354"
] | Doxycycline | Oxacillin | Doxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline]. It is a second-generation tetracycline that was first discovered in 1967. Second-generation tetracyclines exhibit lesser toxicity than first-generation tetracyclines. Doxycycline is used to treat a wide variety of gram-positive and... | An antibiotic similar to [flucloxacillin] used in resistant staphylococci infections. | Moderate | 1 | [
[
[
964,
24,
1138
]
],
[
[
964,
24,
916
],
[
916,
1,
1138
]
],
[
[
964,
24,
1249
],
[
1249,
40,
1138
]
],
[
[
964,
1,
1545
],
[
1545,
... | [
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxacillin"
]
],
[
[
"Doxycycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dicloxacillin"
],
... | Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Dicloxacillin and Dicloxacillin (Compound) resembles Oxacillin (Compound)
Doxycycline may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin (Compound) resembles Oxacillin (Compou... |
DB01410 | DB06448 | 423 | 171 | [
"DDInter375",
"DDInter1087"
] | Ciclesonide | Lonafarnib | Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco. | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Moderate | 1 | [
[
[
423,
24,
171
]
],
[
[
423,
1,
1351
],
[
1351,
24,
171
]
],
[
[
423,
40,
891
],
[
891,
24,
171
]
],
[
[
423,
64,
1064
],
[
1064,
... | [
[
[
"Ciclesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lonafarnib"
]
],
[
[
"Ciclesonide",
"{u} (Compound) resembles {v} (Compound)",
"Flunisolide"
],
[
"Flunisolide",
"{u} may cause a mod... | Ciclesonide (Compound) resembles Flunisolide (Compound) and Flunisolide may cause a moderate interaction that could exacerbate diseases when taken with Lonafarnib
Ciclesonide (Compound) resembles Prednisolone (Compound) and Prednisolone may cause a moderate interaction that could exacerbate diseases when taken with Lon... |
DB00280 | DB12267 | 494 | 1,476 | [
"DDInter575",
"DDInter233"
] | Disopyramide | Brigatinib | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Moderate | 1 | [
[
[
494,
24,
1476
]
],
[
[
494,
24,
629
],
[
629,
24,
1476
]
],
[
[
494,
63,
1184
],
[
1184,
24,
1476
]
],
[
[
494,
25,
918
],
[
918,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brigatinib"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sirolimus"
],
[... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Sirolimus and Sirolimus may cause a moderate interaction that could exacerbate diseases when taken with Brigatinib
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakin... |
DB00844 | DB11817 | 314 | 1,259 | [
"DDInter1257",
"DDInter165"
] | Nalbuphine | Baricitinib | A narcotic used as a pain medication. It appears to be an agonist at kappa opioid receptors and an antagonist or partial agonist at mu opioid receptors. Nalbuphine is the only opioid analgesic that is not a controlled substance in the United States. | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Moderate | 1 | [
[
[
314,
24,
1259
]
],
[
[
314,
40,
421
],
[
421,
24,
1259
]
],
[
[
314,
1,
828
],
[
828,
24,
1259
]
],
[
[
314,
25,
407
],
[
407,
2... | [
[
[
"Nalbuphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Baricitinib"
]
],
[
[
"Nalbuphine",
"{u} (Compound) resembles {v} (Compound)",
"Hydromorphone"
],
[
"Hydromorphone",
"{u} may cause a ... | Nalbuphine (Compound) resembles Hydromorphone (Compound) and Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Baricitinib
Nalbuphine (Compound) resembles Oxycodone (Compound) and Oxycodone may cause a moderate interaction that could exacerbate diseases when taken with Barici... |
DB00526 | DB08860 | 1,555 | 788 | [
"DDInter1355",
"DDInter1479"
] | Oxaliplatin | Pitavastatin | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Pitavastatin, also known as the brand name product Livalo, is a lipid-lowering drug belonging to the statin class of medications. By inhibiting the endogenous production of cholesterol within the liver, statins lower abnormal cholesterol and lipid levels and ultimately reduce the risk of cardiovascular disease. More sp... | Moderate | 1 | [
[
[
1555,
24,
788
]
],
[
[
1555,
24,
671
],
[
671,
1,
788
]
],
[
[
1555,
24,
700
],
[
700,
40,
788
]
],
[
[
1555,
6,
17404
],
[
17404,
... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitavastatin"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
],
... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin (Compound) resembles Pitavastatin (Compound)
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Atorvastatin and Atorvastatin (Compound) resembles Pitavastatin... |
DB00674 | DB00986 | 1,516 | 1,192 | [
"DDInter802",
"DDInter834"
] | Galantamine | Glycopyrronium | Galantamine is a tertiary alkaloid and reversible, competitive inhibitor of the acetylcholinesterase (AChE) enzyme, which is a widely studied therapeutic target used in the treatment of Alzheimer's disease. First characterized in the early 1950s, galantamine is a tertiary alkaloid that was extracted from botanical sour... | Glycopyrronium, also known as NVA237 or glycopyrrolate, is a racemic mixture of two enantiomers. They are both quaternary ammonium compounds and long acting muscarinic antagonists. It is one of the most commonly prescribed anticholinergic medications.[A233535,A233540] Early research into glycopyrronium use was for its ... | Moderate | 1 | [
[
[
1516,
24,
1192
]
],
[
[
1516,
24,
1511
],
[
1511,
63,
1192
]
],
[
[
1516,
24,
262
],
[
262,
24,
1192
]
],
[
[
1516,
21,
29231
],
[
292... | [
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
]
],
[
[
"Galantamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
],
... | Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate and Mepenzolate may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium
Galantamine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and... |
DB00055 | DB01191 | 834 | 1,039 | [
"DDInter605",
"DDInter518"
] | Drotrecogin alfa | Dexfenfluramine | Drotrecogin alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin alfa was withdrawn from the market after a major study indicated th... | Dexfenfluramine, also marketed under the name Redux, is a serotoninergic anorectic drug. For a fairly limited time during the middle of the nineties, the US FDA had approved it for use in managing weight loss. However, following multiple concerns about the cardiovascular side-effects of the drug, such approval was with... | Moderate | 1 | [
[
[
834,
24,
1039
]
],
[
[
834,
25,
1046
],
[
1046,
63,
1039
]
],
[
[
834,
25,
935
],
[
935,
24,
1039
]
],
[
[
834,
64,
1432
],
[
1432,
... | [
[
[
"Drotrecogin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexfenfluramine"
]
],
[
[
"Drotrecogin alfa",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Caplacizumab"
],
... | Drotrecogin alfa may lead to a major life threatening interaction when taken with Caplacizumab and Caplacizumab may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine
Drotrecogin alfa may lead to a major life threatening interaction when taken with Ketoprofen and Ketoprofen may ... |
DB00557 | DB00692 | 252 | 274 | [
"DDInter895",
"DDInter1448"
] | Hydroxyzine | Phentolamine | Hydroxyzine is a first-generation histamine H<sub>1</sub>-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.[A1257,A187589] It was first developed in 1955, and has since remained a relatively common treatment for allergic conditions such as p... | Phentolamine is a reversible, non-selective alpha-adrenergic blocker that induces vasodilation. While initially introduced to the market for the treatment of hypertension, this clinical use was halted due to cardiovascular and gastrointestinal adverse effects with the prolonged use of large oral doses of phentolamine.[... | Moderate | 1 | [
[
[
252,
24,
274
]
],
[
[
252,
21,
28766
],
[
28766,
60,
274
]
],
[
[
252,
63,
530
],
[
530,
24,
274
]
],
[
[
252,
24,
104
],
[
104,
... | [
[
[
"Hydroxyzine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phentolamine"
]
],
[
[
"Hydroxyzine",
"{u} (Compound) causes {v} (Side Effect)",
"Hypotension"
],
[
"Hypotension",
"{u} (Side Effect)... | Hydroxyzine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Phentolamine (Compound)
Hydroxyzine may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with... |
DB00679 | DB04837 | 684 | 649 | [
"DDInter1796",
"DDInter407"
] | Thioridazine | Clofedanol | A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than chlorpromazi... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
684,
24,
649
]
],
[
[
684,
25,
1376
],
[
1376,
24,
649
]
],
[
[
684,
24,
832
],
[
832,
40,
649
]
],
[
[
684,
63,
701
],
[
701,
2... | [
[
[
"Thioridazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Thioridazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diphenhydramine"
],
[
"D... | Thioridazine may lead to a major life threatening interaction when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Thioridazine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tri... |
DB01110 | DB08901 | 86 | 1,468 | [
"DDInter1209",
"DDInter1492"
] | Miconazole | Ponatinib | Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well. It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-ba... | Ponatinib is a novel Bcr-Abl tyrosine kinase inhibitor that is especially effective against the T315I mutation for the treatment of chronic myeloid leukemia. FDA approved on December 14, 2012. | Moderate | 1 | [
[
[
86,
24,
1468
]
],
[
[
86,
24,
478
],
[
478,
24,
1468
]
],
[
[
86,
6,
12523
],
[
12523,
45,
1468
]
],
[
[
86,
7,
5415
],
[
5415,
... | [
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ponatinib"
]
],
[
[
"Miconazole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[
... | Miconazole may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ponatinib
Miconazole (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Ponatinib (Compound)
Miconazole (Compound) ... |
DB00443 | DB11124 | 251 | 209 | [
"DDInter195",
"DDInter1560"
] | Betamethasone | Racepinephrine | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Racepinephrine is a racemic mixture consisting of d- and l- enantiomers. Epinephrine is a non-selective α- and β-adrenergic receptor agonist. It is a bronchodilator used in the temporary relief of mild symptoms of intermittent asthma including wheezing, tightness of chest and shortness of breath. It is an active ingred... | Minor | 0 | [
[
[
251,
23,
209
]
],
[
[
251,
1,
1573
],
[
1573,
23,
209
]
],
[
[
251,
40,
218
],
[
218,
23,
209
]
],
[
[
251,
23,
688
],
[
688,
24... | [
[
[
"Betamethasone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Racepinephrine"
]
],
[
[
"Betamethasone",
"{u} (Compound) resembles {v} (Compound)",
"Prednisone"
],
[
"Prednisone",
"{u} may cause a... | Betamethasone (Compound) resembles Prednisone (Compound) and Prednisone may cause a minor interaction that can limit clinical effects when taken with Racepinephrine
Betamethasone (Compound) resembles Beclomethasone dipropionate (Compound) and Beclomethasone dipropionate may cause a minor interaction that can limit clin... |
DB00990 | DB04575 | 1,547 | 35 | [
"DDInter705",
"DDInter1555"
] | Exemestane | Quinestrol | Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition. | The 3-cyclopentyl ether of ethinyl estradiol. | Moderate | 1 | [
[
[
1547,
24,
35
]
],
[
[
1547,
24,
890
],
[
890,
1,
35
]
],
[
[
1547,
63,
559
],
[
559,
1,
35
]
],
[
[
1547,
35,
177
],
[
177,
40,
... | [
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinestrol"
]
],
[
[
"Exemestane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mestranol"
],
[
... | Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Mestranol and Mestranol (Compound) resembles Quinestrol (Compound)
Exemestane may cause a moderate interaction that could exacerbate diseases when taken with Estrone and Estrone (Compound) resembles Quinestrol (Compound)
Exemesta... |
DB00544 | DB06688 | 970 | 1,430 | [
"DDInter757",
"DDInter1677"
] | Fluorouracil | Sipuleucel-T | A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid. | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
970,
24,
1430
]
],
[
[
970,
24,
51
],
[
51,
24,
1430
]
],
[
[
970,
25,
676
],
[
676,
63,
1430
]
],
[
[
970,
40,
132
],
[
132,
24... | [
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Fluorouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
... | Fluorouracil may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Fluorouracil may lead to a major life threatening interaction when taken with Upadacitinib and Upadaciti... |
DB00295 | DB00436 | 475 | 323 | [
"DDInter1244",
"DDInter179"
] | Morphine | Bendroflumethiazide | Morphine, the main alkaloid of opium, was first obtained from poppy seeds in 1805. It is a potent analgesic, though its use is limited due to tolerance, withdrawal, and the risk of abuse. Morphine is still routinely used today, though there are a number of semi-synthetic opioids of varying strength such as [codeine], [... | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. It has been used in the treatment of familial hyperkalemia, hypertension, edema, and urinary tract disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p810) | Moderate | 1 | [
[
[
475,
24,
323
]
],
[
[
475,
24,
1014
],
[
1014,
1,
323
]
],
[
[
475,
21,
28766
],
[
28766,
60,
323
]
],
[
[
475,
24,
262
],
[
262,
... | [
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bendroflumethiazide"
]
],
[
[
"Morphine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Benzthiazide"
],
... | Morphine may cause a moderate interaction that could exacerbate diseases when taken with Benzthiazide and Benzthiazide (Compound) resembles Bendroflumethiazide (Compound)
Morphine (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is caused by Bendroflumethiazide (Compound)
Morphine may cause a m... |
DB00092 | DB14881 | 58 | 180 | [
"DDInter40",
"DDInter1329"
] | Alefacept | Oliceridine | Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD. | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
58,
24,
180
]
],
[
[
58,
63,
1184
],
[
1184,
24,
180
]
],
[
[
58,
24,
36
],
[
36,
24,
180
]
],
[
[
58,
25,
976
],
[
976,
24,
... | [
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Alefacept",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anakinra"
],
[
... | Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin may ... |
DB00065 | DB06372 | 581 | 259 | [
"DDInter923",
"DDInter1594"
] | Infliximab | Rilonacept | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Major | 2 | [
[
[
581,
25,
259
]
],
[
[
581,
23,
1114
],
[
1114,
62,
259
]
],
[
[
581,
23,
1461
],
[
1461,
23,
259
]
],
[
[
581,
25,
0
],
[
0,
24,... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
]
],
[
[
"Infliximab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zinc sulfate"
],
[
"Zinc sulfa... | Infliximab may cause a minor interaction that can limit clinical effects when taken with Zinc sulfate and Zinc sulfate may cause a minor interaction that can limit clinical effects when taken with Rilonacept
Infliximab may cause a minor interaction that can limit clinical effects when taken with Vitamin E and Vitamin E... |
DB00515 | DB00741 | 589 | 167 | [
"DDInter387",
"DDInter885"
] | Cisplatin | Hydrocortisone | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions.[L10529,L10532,L10535,L10538,L7772,L7321] It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone. Hydrocortisone wa... | Moderate | 1 | [
[
[
589,
24,
167
]
],
[
[
589,
24,
1220
],
[
1220,
40,
167
]
],
[
[
589,
24,
870
],
[
870,
1,
167
]
],
[
[
589,
63,
251
],
[
251,
40... | [
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrocortisone"
]
],
[
[
"Cisplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
],
... | Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Hydrocortisone (Compound)
Cisplatin may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone (Compound) resembles Hydr... |
DB00776 | DB12001 | 1,335 | 564 | [
"DDInter1360",
"DDInter7"
] | Oxcarbazepine | Abemaciclib | Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L8633] It is a structural derivative of [carbamazepine] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exis... | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
1335,
24,
564
]
],
[
[
1335,
24,
868
],
[
868,
24,
564
]
],
[
[
1335,
63,
723
],
[
723,
24,
564
]
],
[
[
1335,
62,
1101
],
[
1101,
... | [
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Oxcarbazepine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vemurafenib"
],
... | Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemurafenib may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Oxcarbazepine may cause a moderate interaction that could exacerbate diseases when taken with Aprepitant a... |
DB01234 | DB06414 | 1,220 | 655 | [
"DDInter513",
"DDInter703"
] | Dexamethasone | Etravirine | Dexamethasone, or MK-125, is a corticosteroid fluorinated at position 9 used to treat endocrine, rheumatic, collagen, dermatologic, allergic, ophthalmic, gastrointestinal, respiratory, hematologic, neoplastic, edematous, and other conditions. Developed in 1957, it is structurally similar to other corticosteroids like [... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
1220,
24,
655
]
],
[
[
1220,
25,
786
],
[
786,
40,
655
]
],
[
[
1220,
6,
4973
],
[
4973,
45,
655
]
],
[
[
1220,
21,
28680
],
[
28680,
... | [
[
[
"Dexamethasone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Dexamethasone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilpivirine"
],
[
"Ril... | Dexamethasone may lead to a major life threatening interaction when taken with Rilpivirine and Rilpivirine (Compound) resembles Etravirine (Compound)
Dexamethasone (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Dexamethasone (Compound) causes Rash (Side Effect) and Rash (Side Effect) i... |
DB00653 | DB01339 | 544 | 728 | [
"DDInter1120",
"DDInter1922"
] | Magnesium sulfate | Vecuronium | A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions... | Monoquaternary homolog of pancuronium. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide ad... | Moderate | 1 | [
[
[
544,
24,
728
]
],
[
[
544,
24,
1610
],
[
1610,
1,
728
]
],
[
[
544,
24,
1579
],
[
1579,
40,
728
]
],
[
[
544,
21,
28642
],
[
28642,
... | [
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vecuronium"
]
],
[
[
"Magnesium sulfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rocuronium"
... | Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Rocuronium and Rocuronium (Compound) resembles Vecuronium (Compound)
Magnesium sulfate may cause a moderate interaction that could exacerbate diseases when taken with Pancuronium and Pancuronium (Compound) resembles Vecuro... |
DB00169 | DB00390 | 386 | 1,252 | [
"DDInter367",
"DDInter554"
] | Cholecalciferol | Digoxin | Vitamin D, in general, is a secosteroid generated in the skin when 7-dehydrocholesterol located there interacts with ultraviolet irradiation - like that commonly found in sunlight. Both the endogenous form of vitamin D (that results from 7-dehydrocholesterol transformation), vitamin D3 (cholecalciferol), and the plant-... | Digoxin is one of the oldest cardiovascular medications used today. It is a common agent used to manage atrial fibrillation and the symptoms of heart failure. Digoxin is classified as a cardiac glycoside and was initially approved by the FDA in 1954. This drug originates from the foxglove plant, also known as the _Digi... | Moderate | 1 | [
[
[
386,
24,
1252
]
],
[
[
386,
24,
1482
],
[
1482,
40,
1252
]
],
[
[
386,
6,
6276
],
[
6276,
45,
1252
]
],
[
[
386,
6,
2710
],
[
2710,
... | [
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digoxin"
]
],
[
[
"Cholecalciferol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Digitoxin"
],
... | Cholecalciferol may cause a moderate interaction that could exacerbate diseases when taken with Digitoxin and Digitoxin (Compound) resembles Digoxin (Compound)
Cholecalciferol (Compound) binds CYP11A1 (Gene) and CYP11A1 (Gene) is bound by Digoxin (Compound)
Cholecalciferol (Compound) binds CDC25A (Gene) and CDC25A (Gen... |
DB00726 | DB00927 | 1,164 | 1,559 | [
"DDInter1876",
"DDInter712"
] | Trimipramine | Famotidine | Tricyclic antidepressant similar to imipramine, but with more antihistaminic and sedative properties. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
1164,
24,
1559
]
],
[
[
1164,
6,
10215
],
[
10215,
45,
1559
]
],
[
[
1164,
21,
28826
],
[
28826,
60,
1559
]
],
[
[
1164,
23,
112
],
[
... | [
[
[
"Trimipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Trimipramine",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compo... | Trimipramine (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Famotidine (Compound)
Trimipramine (Compound) causes Jaundice (Side Effect) and Jaundice (Side Effect) is caused by Famotidine (Compound)
Trimipramine may cause a minor interaction that can limit clinical effects when taken with Metronidazole a... |
DB05679 | DB14443 | 1,683 | 987 | [
"DDInter1907",
"DDInter1931"
] | Ustekinumab | Vibrio cholerae CVD 103-HgR strain live antigen | Ustekinumab is a human immunoglobulin (Ig) G1 kappa monoclonal antibody directed against interleukin(IL)-12 and IL-23, which are cytokines that are involved in immune and inflammatory responses. It was generated via recombinant human IL-12 immunization of human Ig (hu-Ig) transgenic mice. It is a targeted biologic dise... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
1683,
24,
987
]
],
[
[
1683,
24,
1480
],
[
1480,
24,
987
]
],
[
[
1683,
63,
141
],
[
141,
24,
987
]
],
[
[
1683,
25,
1583
],
[
1583,
... | [
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Ustekinumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Ustekinumab may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Ustekinumab may cause a moderate interaction that could exacerbate diseases wh... |
DB06273 | DB13007 | 980 | 1,060 | [
"DDInter1824",
"DDInter642"
] | Tocilizumab | Enfortumab vedotin | Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. It was first described in the literature in 2003 when Chugai, a subsidiary of Roche began developing IL-6 inhibiting monoclonal antibodies. Tocilizumab was granted FDA approval on 8 J... | Enfortumab vedotin is an antibody-drug conjugate used in the treatment of patients with advanced, treatment-resistant urothelial cancers. It is comprised of a fully human monoclonal antibody targeted against Nectin-4 and a microtubule-disrupting chemotherapeutic agent, monomethyl auristatin E (MMAE), joined by a protea... | Moderate | 1 | [
[
[
980,
24,
1060
]
],
[
[
980,
24,
1593
],
[
1593,
24,
1060
]
],
[
[
980,
63,
1439
],
[
1439,
24,
1060
]
],
[
[
980,
64,
1531
],
[
1531,
... | [
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enfortumab vedotin"
]
],
[
[
"Tocilizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Crizotinib"
]... | Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Crizotinib and Crizotinib may cause a moderate interaction that could exacerbate diseases when taken with Enfortumab vedotin
Tocilizumab may cause a moderate interaction that could exacerbate diseases when taken with Ipilimumab ... |
DB00526 | DB13985 | 1,555 | 546 | [
"DDInter1355",
"DDInter1108"
] | Oxaliplatin | Lutetium Lu 177 dotatate | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | A 177Lu-labeled somatostatin analog peptide, Lutetium Lu 177 dotatate belongs to an emerging form of treatments called Peptide Receptor Radionuclide Therapy (PRRT), which involves targeting tumours with molecules carrying radioactive particles that bind to specific receptors expressed by the tumour. Lutetium Lu 177 dot... | Moderate | 1 | [
[
[
1555,
24,
546
]
],
[
[
1555,
24,
50
],
[
50,
24,
546
]
],
[
[
1555,
63,
66
],
[
66,
24,
546
]
],
[
[
1555,
25,
869
],
[
869,
24,... | [
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lutetium Lu 177 dotatate"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfasalazi... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Sulfasalazine and Sulfasalazine may cause a moderate interaction that could exacerbate diseases when taken with Lutetium Lu 177 dotatate
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01097 | DB04951 | 1,377 | 187 | [
"DDInter1033",
"DDInter1477"
] | Leflunomide | Pirfenidone | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Major | 2 | [
[
[
1377,
25,
187
]
],
[
[
1377,
64,
168
],
[
168,
23,
187
]
],
[
[
1377,
25,
637
],
[
637,
63,
187
]
],
[
[
1377,
64,
463
],
[
463,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Pirfenidone"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
"{u... | Leflunomide may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pirfenidone
Leflunomide may lead to a major life threatening interaction when taken with Asparaginase Erwinia chrysanthemi and Asparaginase... |
DB00312 | DB00675 | 1,023 | 888 | [
"DDInter1423",
"DDInter1744"
] | Pentobarbital | Tamoxifen | A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Dr... | Tamoxifen is a non-steroidal antiestrogen used to treat estrogen receptor positive breast cancers as well as prevent the incidence of breast cancer in high risk populations.[A1025,L7799,L7802] Tamoxifen is used alone or as an adjuvant in these treatments.[L7799,L7802] Tamoxifen may no longer be the preferred treatment ... | Moderate | 1 | [
[
[
1023,
24,
888
]
],
[
[
1023,
24,
832
],
[
832,
40,
888
]
],
[
[
1023,
24,
649
],
[
649,
1,
888
]
],
[
[
1023,
24,
1376
],
[
1376,
... | [
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tamoxifen"
]
],
[
[
"Pentobarbital",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],... | Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine (Compound) resembles Tamoxifen (Compound)
Pentobarbital may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofedanol (Compound) resembles Tamoxifen... |
DB04948 | DB11130 | 1,084 | 407 | [
"DDInter1083",
"DDInter1344"
] | Lofexidine | Opium | Lofexidine is a non-opioid centrally acting alpha2-adrenergic receptor agonist that was first approved for the treatment of opioid withdrawal in the United Kingdom in 1992. It was first studied for use as an antihypertensive in 1980, but its researched was stopped as it was found less effective for the treatment of hyp... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1084,
24,
407
]
],
[
[
1084,
63,
662
],
[
662,
24,
407
]
],
[
[
1084,
24,
976
],
[
976,
24,
407
]
],
[
[
1084,
40,
1020
],
[
1020,
... | [
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Lofexidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
[
... | Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Lofexidine may cause a moderate interaction that could exacerbate diseases when taken with Tofacitinib and Tofa... |
DB00205 | DB09293 | 929 | 116 | [
"DDInter1550",
"DDInter954"
] | Pyrimethamine | Iodide I-131 | One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
929,
24,
116
]
],
[
[
929,
24,
1247
],
[
1247,
24,
116
]
],
[
[
929,
24,
1247
],
[
1247,
23,
1487
],
[
1487,
24,
116
]
],
[
[
929,
... | [
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Pyrimethamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole"
... | Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Pyrimethamine may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB00327 | DB00486 | 421 | 1,614 | [
"DDInter890",
"DDInter1253"
] | Hydromorphone | Nabilone | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Moderate | 1 | [
[
[
421,
24,
1614
]
],
[
[
421,
24,
530
],
[
530,
1,
1614
]
],
[
[
421,
21,
28863
],
[
28863,
60,
1614
]
],
[
[
421,
24,
999
],
[
999,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronabinol"
],
... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Dronabinol and Dronabinol (Compound) resembles Nabilone (Compound)
Hydromorphone (Compound) causes Lightheadedness (Side Effect) and Lightheadedness (Side Effect) is caused by Nabilone (Compound)
Hydromorphone may cause a mode... |
DB00425 | DB01246 | 558 | 820 | [
"DDInter1970",
"DDInter45"
] | Zolpidem | Alimemazine | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
558,
24,
820
]
],
[
[
558,
24,
401
],
[
401,
24,
820
]
],
[
[
558,
24,
649
],
[
649,
1,
820
]
],
[
[
558,
6,
8374
],
[
8374,
45,... | [
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Zolpidem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Zolpidem may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clofe... |
DB00188 | DB14568 | 168 | 982 | [
"DDInter222",
"DDInter1000"
] | Bortezomib | Ivosidenib | Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest ... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Minor | 0 | [
[
[
168,
23,
982
]
],
[
[
168,
24,
112
],
[
112,
23,
982
]
],
[
[
168,
23,
1101
],
[
1101,
23,
982
]
],
[
[
168,
25,
976
],
[
976,
2... | [
[
[
"Bortezomib",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Ivosidenib"
]
],
[
[
"Bortezomib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
... | Bortezomib may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Bortezomib may cause a minor interaction that can limit clinical effects when taken with Bexarotene and Bexa... |
DB00176 | DB00431 | 529 | 1,503 | [
"DDInter770",
"DDInter1072"
] | Fluvoxamine | Lindane | Fluvoxamine is an antidepressant which functions pharmacologically as a selective serotonin reuptake inhibitor. Though it is in the same class as other SSRI drugs, it is most often used to treat obsessive-compulsive disorder. Fluvoxamine has been in use in clinical practice since 1983 and has a clinical trial database ... | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | Moderate | 1 | [
[
[
529,
24,
1503
]
],
[
[
529,
21,
28703
],
[
28703,
60,
1503
]
],
[
[
529,
24,
475
],
[
475,
24,
1503
]
],
[
[
529,
25,
222
],
[
222,
... | [
[
[
"Fluvoxamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lindane"
]
],
[
[
"Fluvoxamine",
"{u} (Compound) causes {v} (Side Effect)",
"Pruritus"
],
[
"Pruritus",
"{u} (Side Effect) is caused ... | Fluvoxamine (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Lindane (Compound)
Fluvoxamine may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction that could exacerbate diseases when taken with Lindane
Fluvox... |
DB06077 | DB08896 | 879 | 292 | [
"DDInter1102",
"DDInter1576"
] | Lumateperone | Regorafenib | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Regorafenib is an orally-administered inhibitor of multiple kinases. It is used for the treatment of metastatic colorectal cancer, advanced gastrointestinal stromal tumours, and hepatocellular carcinoma. FDA approved on September 27, 2012. Approved use of Regorafenib was expanded to treat Hepatocellular Carcinoma in Ap... | Moderate | 1 | [
[
[
879,
24,
292
]
],
[
[
879,
63,
79
],
[
79,
1,
292
]
],
[
[
879,
24,
549
],
[
549,
23,
292
]
],
[
[
879,
25,
1604
],
[
1604,
63,
... | [
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib (Compound) resembles Regorafenib (Compound)
Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a minor interaction that... |
DB00835 | DB00981 | 100 | 1,528 | [
"DDInter245",
"DDInter1463"
] | Brompheniramine | Physostigmine (ophthalmic) | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Physostigmine is a carbamate ester and an indole alkaloid. It has a role as a miotic, an EC 3.1.1.8 (cholinesterase) inhibitor and an antidote to curare poisoning. | Moderate | 1 | [
[
[
100,
24,
1528
]
],
[
[
100,
63,
508
],
[
508,
24,
1528
]
],
[
[
100,
24,
1511
],
[
1511,
63,
1528
]
],
[
[
100,
24,
543
],
[
543,
... | [
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Brompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promazine"
... | Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Physostigmine
Brompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Physostigm... |
DB00618 | DB00688 | 1,572 | 955 | [
"DDInter498",
"DDInter1251"
] | Demeclocycline | Mycophenolate mofetil | A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. | Mycophenolate mofetil, also known as MMF or CellCept, is a prodrug of mycophenolic acid, and classified as a reversible inhibitor of inosine monophosphate dehydrogenase (IMPDH). This drug is an immunosuppressant combined with drugs such as [Cyclosporine] and corticosteroids to prevent organ rejection after hepatic, ren... | Moderate | 1 | [
[
[
1572,
24,
955
]
],
[
[
1572,
24,
1096
],
[
1096,
40,
955
]
],
[
[
1572,
24,
1114
],
[
1114,
62,
955
]
],
[
[
1572,
63,
1031
],
[
1031,... | [
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophenolate mofetil"
]
],
[
[
"Demeclocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mycophen... | Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Mycophenolic acid and Mycophenolic acid (Compound) resembles Mycophenolate mofetil (Compound)
Demeclocycline may cause a moderate interaction that could exacerbate diseases when taken with Zinc sulfate and Zinc sulfate may ca... |
DB00307 | DB01259 | 1,101 | 392 | [
"DDInter202",
"DDInter1024"
] | Bexarotene | Lapatinib | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Lapatinib is an anti-cancer drug developed by GlaxoSmithKline (GSK) as a treatment for solid tumours such as breast and lung cancer. It was approved by the FDA on March 13, 2007, for use in patients with advanced metastatic breast cancer in conjunction with the chemotherapy drug capecitabine. Lapatinib is a human epide... | Moderate | 1 | [
[
[
1101,
24,
392
]
],
[
[
1101,
6,
8374
],
[
8374,
45,
392
]
],
[
[
1101,
21,
28688
],
[
28688,
60,
392
]
],
[
[
1101,
23,
271
],
[
271,
... | [
[
[
"Bexarotene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lapatinib"
]
],
[
[
"Bexarotene",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Bexarotene (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Lapatinib (Compound)
Bexarotene (Compound) causes Epistaxis (Side Effect) and Epistaxis (Side Effect) is caused by Lapatinib (Compound)
Bexarotene may cause a minor interaction that can limit clinical effects when taken with Mirabegron and Mirabegr... |
DB00813 | DB09065 | 704 | 760 | [
"DDInter722",
"DDInter424"
] | Fentanyl | Cobicistat | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
704,
25,
760
]
],
[
[
704,
63,
1101
],
[
1101,
23,
760
]
],
[
[
704,
64,
723
],
[
723,
24,
760
]
],
[
[
704,
24,
868
],
[
868,
2... | [
[
[
"Fentanyl",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene",
... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Fentanyl may lead to a major life threatening interaction when taken with Aprepitant and Aprepitant may cause a mode... |
DB08868 | DB09122 | 1,011 | 1,613 | [
"DDInter737",
"DDInter1409"
] | Fingolimod | Peginterferon beta-1a | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1011,
24,
1613
]
],
[
[
1011,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
1011,
25,
975
],
[
975,
63,
1613
]
],
[
[
1011,
64,
600
],
[
600,
... | [
[
[
"Fingolimod",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Fingolimod",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
... | Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Cannabidiol and Cannabidiol may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Fingolimod may lead to a major life threatening interaction when taken with Lurbinectedin and Lurbi... |
DB00014 | DB01177 | 521 | 77 | [
"DDInter839",
"DDInter904"
] | Goserelin | Idarubicin | Goserelin is a synthetic hormone. In men, it stops the production of the hormone testosterone, which may stimulate the growth of cancer cells. In women, goserelin decreases the production of the hormone estradiol (which may stimulate the growth of cancer cells) to levels similar to a postmenopausal state. When the medi... | An orally administered anthracycline antineoplastic. The compound has shown activity against breast cancer, lymphomas and leukemias, together with the potential for reduced cardiac toxicity. | Moderate | 1 | [
[
[
521,
24,
77
]
],
[
[
521,
5,
11579
],
[
11579,
44,
77
]
],
[
[
521,
21,
28931
],
[
28931,
60,
77
]
],
[
[
521,
24,
739
],
[
739,
... | [
[
[
"Goserelin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idarubicin"
]
],
[
[
"Goserelin",
"{u} (Compound) treats {v} (Disease)",
"breast cancer"
],
[
"breast cancer",
"{u} (Disease) is treate... | Goserelin (Compound) treats breast cancer (Disease) and breast cancer (Disease) is treated by Idarubicin (Compound)
Goserelin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Idarubicin (Compound)
Goserelin may cause a moderate interaction that could exacerbate diseases when taken ... |
DB00013 | DB00078 | 1,255 | 1,172 | [
"DDInter1905",
"DDInter898"
] | Urokinase | Ibritumomab tiuxetan | Urokinase is an endogenous peptide that is cleaved in the presence of plasmin between lysine 158 and isoleucine 159 to yield active urokinase. Urokinase remains connected between these 2 chains by a sulfhydryl bond. Urokinase was granted FDA approval on 16 January 1978. | Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light... | Major | 2 | [
[
[
1255,
25,
1172
]
],
[
[
1255,
23,
539
],
[
539,
62,
1172
]
],
[
[
1255,
24,
578
],
[
578,
63,
1172
]
],
[
[
1255,
24,
1338
],
[
1338,
... | [
[
[
"Urokinase",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibritumomab tiuxetan"
]
],
[
[
"Urokinase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
"Capsic... | Urokinase may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Ibritumomab tiuxetan
Urokinase may cause a moderate interaction that could exacerbate diseases when taken with Ticagrelor and Ticagr... |
DB01309 | DB09413 | 1,254 | 1,203 | [
"DDInter933",
"DDInter1241"
] | Insulin glulisine | Monopotassium phosphate | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Monopotassium phosphate, MKP, (also potassium dihydrogenphosphate, KDP, or monobasic potassium phosphate), KH2PO4, is a soluble salt of potassium and the dihydrogen phosphate ion. It is a source of phosphorus and potassium as well as a buffering agent. It can be used in fertilizer mixtures to reduce escape of ammonia b... | Minor | 0 | [
[
[
1254,
23,
1203
]
],
[
[
1254,
24,
22
],
[
22,
23,
1203
]
],
[
[
1254,
63,
1445
],
[
1445,
23,
1203
]
],
[
[
1254,
24,
22
],
[
22,
... | [
[
[
"Insulin glulisine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Monopotassium phosphate"
]
],
[
[
"Insulin glulisine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ep... | Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken with Ephedrine and Ephedrine may cause a minor interaction that can limit clinical effects when taken with Monopotassium phosphate
Insulin glulisine may cause a moderate interaction that could exacerbate diseases when taken wit... |
DB00881 | DB01124 | 954 | 1,411 | [
"DDInter1554",
"DDInter1828"
] | Quinapril | Tolbutamide | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Moderate | 1 | [
[
[
954,
24,
1411
]
],
[
[
954,
24,
959
],
[
959,
40,
1411
]
],
[
[
954,
63,
245
],
[
245,
40,
1411
]
],
[
[
954,
6,
4610
],
[
4610,
... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tolbutamide"
]
],
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
],
[
... | Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Glipizide and Glipizide (Compound) resembles Tolbutamide (Compound)
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Tolbutamide (Compound)
... |
DB00215 | DB01268 | 1,230 | 1,151 | [
"DDInter388",
"DDInter1731"
] | Citalopram | Sunitinib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Sunitinib is a small-molecule multi-targeted receptor tyrosine kinase (RTK) inhibitor. On January 26, 2006, the agent was formally approved by the US FDA for the indications of treating renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST). For these purposes, sunitinib is generally av... | Major | 2 | [
[
[
1230,
25,
1151
]
],
[
[
1230,
24,
1311
],
[
1311,
1,
1151
]
],
[
[
1230,
6,
4973
],
[
4973,
45,
1151
]
],
[
[
1230,
21,
29662
],
[
296... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sunitinib"
]
],
[
[
"Citalopram",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramide"
],
[
"Metoclo... | Citalopram may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide (Compound) resembles Sunitinib (Compound)
Citalopram (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Sunitinib (Compound)
Citalopram (Compound) causes Candida infection (Side Effect) a... |
DB06799 | DB09154 | 212 | 1,475 | [
"DDInter1169",
"DDInter1686"
] | Methenamine | Sodium citrate | Methenamine is a heterocyclic organic compound with a cage-like structure similar to adamantane. In salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine). | Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water, practically insoluble in alcohol. Like citric acid, it has a sour taste. From the medical point of view, it is used as alkalinizing agent. It works ... | Moderate | 1 | [
[
[
212,
24,
1475
]
],
[
[
212,
63,
115
],
[
115,
25,
1475
]
],
[
[
212,
63,
1283
],
[
1283,
62,
743
],
[
743,
23,
1475
]
],
[
[
212,
... | [
[
[
"Methenamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium citrate"
]
],
[
[
"Methenamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aluminum hydroxide"
... | Methenamine may cause a moderate interaction that could exacerbate diseases when taken with Aluminum hydroxide and Aluminum hydroxide may lead to a major life threatening interaction when taken with Sodium citrate
Methenamine may cause a moderate interaction that could exacerbate diseases when taken with Magnesium oxid... |
DB04855 | DB11581 | 540 | 1,456 | [
"DDInter602",
"DDInter1926"
] | Dronedarone | Venetoclax | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Venetoclax is a BCL-2 inhibitor that was initially approved by the FDA in April 2016 [FDA label]. Proteins in the B cell CLL/lymphoma 2 (BCL-2) family are important regulators of the apoptotic (programmed cell death) process , . Venetoclax is used to treat chronic lymphocytic leukemia (CLL) and certain types of small l... | Major | 2 | [
[
[
540,
25,
1456
]
],
[
[
540,
25,
1135
],
[
1135,
23,
1456
]
],
[
[
540,
25,
1476
],
[
1476,
63,
1456
]
],
[
[
540,
63,
86
],
[
86,
... | [
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Venetoclax"
]
],
[
[
"Dronedarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Naloxegol"
],
[
"Naloxegol",
"{u} m... | Dronedarone may lead to a major life threatening interaction when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Venetoclax
Dronedarone may lead to a major life threatening interaction when taken with Brigatinib and Brigatinib may cause a moderate intera... |
DB00530 | DB01118 | 1,195 | 33 | [
"DDInter667",
"DDInter76"
] | Erlotinib | Amiodarone | Erlotinib is an inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase that is used in the treatment of non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is typically marketed under the trade name Tarceva. Erlotinib binds to the epidermal growth factor receptor (EGFR)... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
1195,
24,
33
]
],
[
[
1195,
6,
7950
],
[
7950,
45,
33
]
],
[
[
1195,
18,
9650
],
[
9650,
46,
33
]
],
[
[
1195,
7,
9242
],
[
9242,
... | [
[
[
"Erlotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Erlotinib",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
... | Erlotinib (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Amiodarone (Compound)
Erlotinib (Compound) downregulates HMGCS1 (Gene) and HMGCS1 (Gene) is upregulated by Amiodarone (Compound)
Erlotinib (Compound) upregulates WDR7 (Gene) and WDR7 (Gene) is upregulated by Amiodarone (Compound)
Erlotinib (Compound... |
DB04865 | DB12159 | 4 | 12 | [
"DDInter1335",
"DDInter609"
] | Omacetaxine mepesuccinate | Dupilumab | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Dupilumab is a fully human monoclonal antibody of the immunoglobulin G4 subclass that binds to the interleukin-4 (IL-4) receptor, inhibiting the receptor signaling pathways. As an interleukin-4 receptor alpha antagonist, dupilumab inhibits the signaling of pro-inflammatory cytokines, called interleukins (IL), that indu... | Moderate | 1 | [
[
[
4,
24,
12
]
],
[
[
4,
63,
599
],
[
599,
24,
12
]
],
[
[
4,
24,
1136
],
[
1136,
24,
12
]
],
[
[
4,
24,
287
],
[
287,
63,
12... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dupilumab"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Dupilumab
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when t... |
DB01138 | DB01225 | 804 | 500 | [
"DDInter1726",
"DDInter645"
] | Sulfinpyrazone | Enoxaparin | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies. Enoxaparin markedly reduces the inc... | Major | 2 | [
[
[
804,
25,
500
]
],
[
[
804,
24,
557
],
[
557,
63,
500
]
],
[
[
804,
63,
222
],
[
222,
24,
500
]
],
[
[
804,
40,
998
],
[
998,
25,... | [
[
[
"Sulfinpyrazone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enoxaparin"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
],
[
... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid and Deoxycholic acid may cause a moderate interaction that could exacerbate diseases when taken with Enoxaparin
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with S... |
DB01242 | DB06282 | 1,237 | 516 | [
"DDInter410",
"DDInter1053"
] | Clomipramine | Levocetirizine | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Levocetirizine is a selective histamine H<sub>1</sub> antagonist used to treat a variety of allergic symptoms.[A181748,A181790,L7694] It is the R enantiomer of [cetirizine]. Levocetirizine has greater affinity for the histamine H<sub>1</sub> receptor than cetirizine. Levocetirizine was granted FDA approval in 1995. | Moderate | 1 | [
[
[
1237,
24,
516
]
],
[
[
1237,
63,
701
],
[
701,
24,
516
]
],
[
[
1237,
40,
1178
],
[
1178,
24,
516
]
],
[
[
1237,
24,
407
],
[
407,
... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levocetirizine"
]
],
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Clomipramine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine
Clomipramine (Compound) resembles Trifluoperazine (Compound) and Trifluoperazine may cause a moderate inte... |
DB00280 | DB00927 | 494 | 1,559 | [
"DDInter575",
"DDInter712"
] | Disopyramide | Famotidine | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Moderate | 1 | [
[
[
494,
24,
1559
]
],
[
[
494,
6,
8803
],
[
8803,
45,
1559
]
],
[
[
494,
21,
28747
],
[
28747,
60,
1559
]
],
[
[
494,
24,
286
],
[
286,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
]
],
[
[
"Disopyramide",
"{u} (Compound) binds {v} (Gene)",
"SLC22A2"
],
[
"SLC22A2",
"{u} (Gene) is bound by {v} (Compo... | Disopyramide (Compound) binds SLC22A2 (Gene) and SLC22A2 (Gene) is bound by Famotidine (Compound)
Disopyramide (Compound) causes Pollakiuria (Side Effect) and Pollakiuria (Side Effect) is caused by Famotidine (Compound)
Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Magnesi... |
DB00563 | DB09074 | 663 | 1,362 | [
"DDInter1174",
"DDInter1327"
] | Methotrexate | Olaparib | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
663,
24,
1362
]
],
[
[
663,
24,
725
],
[
725,
63,
1362
]
],
[
[
663,
24,
896
],
[
896,
24,
1362
]
],
[
[
663,
63,
139
],
[
139,
... | [
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Methotrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Satralizumab"
],
... | Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Satralizumab and Satralizumab may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and E... |
DB06674 | DB12267 | 908 | 1,476 | [
"DDInter837",
"DDInter233"
] | Golimumab | Brigatinib | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Brigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It also exhibits selectivity against 9 different Crizotinib-resistant mutants of the E... | Major | 2 | [
[
[
908,
25,
1476
]
],
[
[
908,
64,
168
],
[
168,
23,
1476
]
],
[
[
908,
64,
629
],
[
629,
24,
1476
]
],
[
[
908,
25,
951
],
[
951,
... | [
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brigatinib"
]
],
[
[
"Golimumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bortezomib"
],
[
"Bortezomib",
"{u} may... | Golimumab may lead to a major life threatening interaction when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Brigatinib
Golimumab may lead to a major life threatening interaction when taken with Sirolimus and Sirolimus may cause a moderate interactio... |
DB00011 | DB08868 | 1,451 | 1,011 | [
"DDInter944",
"DDInter737"
] | Interferon alfa-n1 | Fingolimod | Interferon alfa-n1 consists of purified, natural (n is for natural) alpha interferon subtypes, at least two of which are glycosylated. This differs from recombinant alpha interferons, which are individual non-glycosylated proteins produced from individual alpha interferon genes. | Multiple sclerosis, or MS, is a devastating inflammatory disease that often progresses and causes severe neurological, physical, and cognitive effects. Fingolimod is a sphingosine 1-phosphate receptor modulator for the treatment of relapsing-remitting multiple sclerosis. It was developed by Novartis and initially appro... | Major | 2 | [
[
[
1451,
25,
1011
]
],
[
[
1451,
24,
112
],
[
112,
23,
1011
]
],
[
[
1451,
24,
242
],
[
242,
63,
1011
]
],
[
[
1451,
24,
1136
],
[
1136,
... | [
[
[
"Interferon alfa-n1",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
]
],
[
[
"Interferon alfa-n1",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Fingolimod
Interferon alfa-n1 may cause a moderate interaction that could exacerbate diseases when taken with R... |
DB00364 | DB00372 | 417 | 999 | [
"DDInter1717",
"DDInter1793"
] | Sucralfate | Thiethylperazine | Sucralfate is a medication that is widely used to prevent and treat a number of diseases in the gastrointestinal tract such as duodenal ulcers [FDA label], gastro-esophageal reflux disease (GERD), gastritis, peptic ulcer disease, stress ulcer, in addition to dyspepsia. It is considered a _cytoprotective agent_, protect... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Minor | 0 | [
[
[
417,
23,
999
]
],
[
[
417,
24,
286
],
[
286,
62,
999
]
],
[
[
417,
23,
17
],
[
17,
63,
999
]
],
[
[
417,
24,
651
],
[
651,
63,
... | [
[
[
"Sucralfate",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Sucralfate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
... | Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Magnesium hydroxide and Magnesium hydroxide may cause a minor interaction that can limit clinical effects when taken with Thiethylperazine
Sucralfate may cause a minor interaction that can limit clinical effects when taken with S... |
DB01097 | DB01611 | 1,377 | 1,487 | [
"DDInter1033",
"DDInter893"
] | Leflunomide | Hydroxychloroquine | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
1377,
25,
1487
]
],
[
[
1377,
21,
28658
],
[
28658,
60,
1487
]
],
[
[
1377,
64,
663
],
[
663,
23,
1487
]
],
[
[
1377,
64,
168
],
[
168... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Vomiting"
],
[
"Vomiting",
"{u} (Side Effect) is caused by {... | Leflunomide (Compound) causes Vomiting (Side Effect) and Vomiting (Side Effect) is caused by Hydroxychloroquine (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Methotrexate and Methotrexate may cause a minor interaction that can limit clinical effects when taken with Hydroxychlor... |
DB00024 | DB08882 | 818 | 1,281 | [
"DDInter1800",
"DDInter1070"
] | Thyrotropin alfa | Linagliptin | Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cance... | Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes . Linagliptin differs from other DPP-4 inhibitors in that it has a non-linear pharmacokinetic profile, is not primarily eliminated by the renal system, and obeys concentration dependant protein binding. Linagliptin ... | Moderate | 1 | [
[
[
818,
24,
1281
]
],
[
[
818,
24,
1002
],
[
1002,
1,
1281
]
],
[
[
818,
24,
1685
],
[
1685,
24,
1281
]
],
[
[
818,
24,
1296
],
[
1296,
... | [
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Linagliptin"
]
],
[
[
"Thyrotropin alfa",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alogliptin"
... | Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Alogliptin and Alogliptin (Compound) resembles Linagliptin (Compound)
Thyrotropin alfa may cause a moderate interaction that could exacerbate diseases when taken with Insulin human and Insulin human may cause a moderate int... |
DB00631 | DB06626 | 372 | 263 | [
"DDInter405",
"DDInter147"
] | Clofarabine | Axitinib | Clofarabine is a purine nucleoside antimetabolite that is being studied in the treatment of cancer. It is marketed as Clolar in the U.S. and Canada, or Evoltra in Europe, Australia, and New Zealand. Clofarabine is used in paediatrics to treat a type of leukaemia called relapsed or refractory acute lymphoblastic leukaem... | Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3). Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit potency that is 50-450 times hi... | Moderate | 1 | [
[
[
372,
24,
263
]
],
[
[
372,
63,
322
],
[
322,
24,
263
]
],
[
[
372,
24,
392
],
[
392,
24,
263
]
],
[
[
372,
24,
1593
],
[
1593,
6... | [
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axitinib"
]
],
[
[
"Clofarabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Epirubicin"
],
[
... | Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Epirubicin and Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Axitinib
Clofarabine may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatin... |
DB01114 | DB11642 | 272 | 938 | [
"DDInter362",
"DDInter1480"
] | Chlorpheniramine | Pitolisant | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
272,
24,
938
]
],
[
[
272,
24,
760
],
[
760,
24,
938
]
],
[
[
272,
40,
28
],
[
28,
24,
938
]
],
[
[
272,
63,
1233
],
[
1233,
24,... | [
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Chlorpheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
... | Chlorpheniramine may cause a moderate interaction that could exacerbate diseases when taken with Cobicistat and Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Chlorpheniramine (Compound) resembles Bisacodyl (Compound) and Bisacodyl may cause a moderate interaction ... |
DB00404 | DB00443 | 523 | 251 | [
"DDInter54",
"DDInter195"
] | Alprazolam | Betamethasone | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties. It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders. Betamethasone has potent glucocorticoid activity and neg... | Minor | 0 | [
[
[
523,
23,
251
]
],
[
[
523,
23,
1486
],
[
1486,
40,
251
]
],
[
[
523,
6,
8374
],
[
8374,
45,
251
]
],
[
[
523,
7,
2969
],
[
2969,
... | [
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Betamethasone"
]
],
[
[
"Alprazolam",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Methylprednisolone"
],
... | Alprazolam may cause a minor interaction that can limit clinical effects when taken with Methylprednisolone and Methylprednisolone (Compound) resembles Betamethasone (Compound)
Alprazolam (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Betamethasone (Compound)
Alprazolam (Compound) upregulates CDKN1A (Gene... |
DB00907 | DB01365 | 290 | 280 | [
"DDInter427",
"DDInter1151"
] | Cocaine (topical) | Mephentermine | Cocaine can cause developmental toxicity and female reproductive toxicity according to an independent committee of scientific and health experts. | A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type depen... | Major | 2 | [
[
[
290,
25,
280
]
],
[
[
290,
64,
551
],
[
551,
1,
280
]
],
[
[
290,
64,
80
],
[
80,
40,
280
]
],
[
[
290,
25,
1161
],
[
1161,
1,
... | [
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mephentermine"
]
],
[
[
"Cocaine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenelzine"
],
[
"Phenelzine",
"{u} (Com... | Cocaine may lead to a major life threatening interaction when taken with Mephentermine
Cocaine may lead to a major life threatening interaction when taken with Phenelzine and Phenelzine (Compound) resembles Mephentermine (Compound)
Cocaine may lead to a major life threatening interaction when taken with Amphetamine and... |
DB04868 | DB15233 | 478 | 1,650 | [
"DDInter1293",
"DDInter142"
] | Nilotinib | Avapritinib | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Avapritinib, or BLU-285, is a selective tyrosine kinase inhibitor of KIT and platelet derived growth factor receptor alpha indicated for the treatment of unresectable, metastatic gastrointestinal stromal tumors and advanced systemic mastocytosis.[A189339,L40363] It is one of the first medications available for the trea... | Moderate | 1 | [
[
[
478,
24,
1650
]
],
[
[
478,
24,
1478
],
[
1478,
24,
1650
]
],
[
[
478,
25,
1374
],
[
1374,
24,
1650
]
],
[
[
478,
64,
1101
],
[
1101,
... | [
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avapritinib"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
],
[
... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor and Ivacaftor may cause a moderate interaction that could exacerbate diseases when taken with Avapritinib
Nilotinib may lead to a major life threatening interaction when taken with Abiraterone and Abiraterone may cause a... |
DB00485 | DB09268 | 916 | 1,662 | [
"DDInter541",
"DDInter1464"
] | Dicloxacillin | Picosulfuric acid | One of the penicillins which is resistant to penicillinase. | Picosulfuric acid is found in laxative products. Sodium picosulfate is a used to treat constipation or induce colon cleansing to prepare the large bowels before colonoscopy or surgery. The combination product containing sodium picosulfate and magnesium citrate was introduced to the Canadian market in 2005 and has been ... | Moderate | 1 | [
[
[
916,
24,
1662
]
],
[
[
916,
1,
319
],
[
319,
24,
1662
]
],
[
[
916,
63,
964
],
[
964,
24,
1662
]
],
[
[
916,
40,
339
],
[
339,
2... | [
[
[
"Dicloxacillin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Picosulfuric acid"
]
],
[
[
"Dicloxacillin",
"{u} (Compound) resembles {v} (Compound)",
"Amoxicillin"
],
[
"Amoxicillin",
"{u} may ... | Dicloxacillin (Compound) resembles Amoxicillin (Compound) and Amoxicillin may cause a moderate interaction that could exacerbate diseases when taken with Picosulfuric acid
Dicloxacillin may cause a moderate interaction that could exacerbate diseases when taken with Doxycycline and Doxycycline may cause a moderate inter... |
DB00959 | DB01336 | 1,486 | 545 | [
"DDInter1191",
"DDInter1198"
] | Methylprednisolone | Metocurine | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Dimethyltubocurarinium (INN) or metocurine (USAN), also known as dimethyltubocurarine, is a non-depolarizing muscle relaxant. Patients on chronic anticonvulsant drugs are relatively resistant to metocurine. | Moderate | 1 | [
[
[
1486,
24,
545
]
],
[
[
1486,
24,
1217
],
[
1217,
40,
545
]
],
[
[
1486,
63,
1031
],
[
1031,
24,
545
]
],
[
[
1486,
40,
1573
],
[
1573,... | [
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metocurine"
]
],
[
[
"Methylprednisolone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tubocurarin... | Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Tubocurarine and Tubocurarine (Compound) resembles Metocurine (Compound)
Methylprednisolone may cause a moderate interaction that could exacerbate diseases when taken with Theophylline and Theophylline may cause a moderat... |
DB00405 | DB04953 | 128 | 495 | [
"DDInter517",
"DDInter708"
] | Dexbrompheniramine | Ezogabine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | Ezogabine (D23129) is a close structural analog of the centrally acting analgesic flupitrine. It is a neuronal potassium channel opener being developed as a first-in-class antiepileptic drug (AED) and is currently being studied in Phase 3 trials as an adjunctive treatment for partial-onset seizures in adult patients wi... | Moderate | 1 | [
[
[
128,
24,
495
]
],
[
[
128,
24,
662
],
[
662,
24,
495
]
],
[
[
128,
24,
1609
],
[
1609,
63,
495
]
],
[
[
128,
74,
1594
],
[
1594,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ezogabine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamin... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Ezogabine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB00106 | DB06603 | 618 | 39 | [
"DDInter4",
"DDInter1387"
] | Abarelix | Panobinostat | Synthetic decapeptide antagonist to gonadotropin releasing hormone (GnRH). It is marketed by Praecis Pharmaceuticals as Plenaxis. Praecis announced in June 2006 that it was voluntarily withdrawing the drug from the market. | Panobinostat is an oral deacetylace (DAC) inhibitor approved on February 23, 2015 by the FDA for the treatment of multiple myeloma. The approval was accelerated based on progression-free survival, therefore confirmatory trials by the sponsor to demonstrate clinical efficacy in multiple myeloma treatment are in progress... | Major | 2 | [
[
[
618,
25,
39
]
],
[
[
618,
23,
1247
],
[
1247,
23,
39
]
],
[
[
618,
24,
479
],
[
479,
23,
39
]
],
[
[
618,
24,
867
],
[
867,
24,
... | [
[
[
"Abarelix",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Panobinostat"
]
],
[
[
"Abarelix",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sulfamethoxazole"
],
[
"Sulfamet... | Abarelix may cause a minor interaction that can limit clinical effects when taken with Sulfamethoxazole and Sulfamethoxazole may cause a minor interaction that can limit clinical effects when taken with Panobinostat
Abarelix may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and D... |
DB00376 | DB04837 | 1,105 | 649 | [
"DDInter1870",
"DDInter407"
] | Trihexyphenidyl | Clofedanol | Trihexyphenidyl is a centrally acting muscarinic antagonist used for treatment of parkinsonism and drug-induced extrapyramidal disorders.[L31773,L31778] Its discovery was published in 1949 in a study looking for drugs with antispasmodic activity. Trihexyphenidyl is rarely used in the treatment of parkinsonism, and is n... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1105,
24,
649
]
],
[
[
1105,
24,
1376
],
[
1376,
24,
649
]
],
[
[
1105,
24,
832
],
[
832,
40,
649
]
],
[
[
1105,
63,
701
],
[
701,
... | [
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Trihexyphenidyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
... | Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Trihexyphenidyl may cause a moderate interaction that could exacerbate diseases when taken with T... |
DB00881 | DB01276 | 954 | 123 | [
"DDInter1554",
"DDInter706"
] | Quinapril | Exenatide | Quinapril is the ethyl ester prodrug of the non-sulfhydryl angiotensin converting enzyme inhibitor quinaprilat.[L8420,L8423] It is used to treat hypertension and heart failure.[L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta b... | Exenatide is a glucagon-like peptide-1 (GLP-1) analog. It activates the GLP-1 receptor and increases insulin secretion, decreases glucagon secretion, and slows gastric emptying to improve glycemic control. Exenatide was given FDA approval on April 28, 2005. It is available as immediate- and extended-release formulation... | Moderate | 1 | [
[
[
954,
24,
123
]
],
[
[
954,
24,
708
],
[
708,
63,
123
]
],
[
[
954,
63,
1573
],
[
1573,
24,
123
]
],
[
[
954,
24,
820
],
[
820,
2... | [
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Exenatide"
]
],
[
[
"Quinapril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Corticotropin"
],
[
... | Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Corticotropin and Corticotropin may cause a moderate interaction that could exacerbate diseases when taken with Exenatide
Quinapril may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Pre... |
DB00615 | DB11730 | 690 | 351 | [
"DDInter1589",
"DDInter1588"
] | Rifabutin | Ribociclib | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Major | 2 | [
[
[
690,
25,
351
]
],
[
[
690,
24,
466
],
[
466,
62,
351
]
],
[
[
690,
24,
112
],
[
112,
23,
351
]
],
[
[
690,
25,
283
],
[
283,
62,... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
]
],
[
[
"Rifabutin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
],
[
"Darolutami... | Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide and Darolutamide may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Rifabutin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Met... |
DB01575 | DB12035 | 1,054 | 943 | [
"DDInter1005",
"DDInter1641"
] | Kaolin | Sarecycline | Kaolin is a layered silicate mineral. Kaolin is used in ceramics, medicine, coated paper, as a food additive, in toothpaste, as a light diffusing material in white incandescent light bulbs, and in cosmetics. Until the early 1990s it was the active substance of anti-diarrhoea medicine Kaopectate. | Sarecycline is a semi-synthetic derivative of tetracycline that was initially discovered by Paratek Pharmaceuticals from Boston, MA but then licensed to Warner Chilcott of Rockaway, NJ in July of 2007 . After completing various phase-II and phase-III trials demonstrating its effectiveness in treating moderate to severe... | Moderate | 1 | [
[
[
1054,
24,
943
]
],
[
[
1054,
62,
17
],
[
17,
62,
417
],
[
417,
24,
943
]
],
[
[
1054,
62,
772
],
[
772,
23,
1283
],
[
1283,
24,
... | [
[
[
"Kaolin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sarecycline"
]
],
[
[
"Kaolin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Sotalol"
],
[
"Sotalol... | Kaolin may cause a minor interaction that can limit clinical effects when taken with Sotalol and Sotalol may cause a minor interaction that can limit clinical effects when taken with Sucralfate and Sucralfate may cause a moderate interaction that could exacerbate diseases when taken with Sarecycline
Kaolin may cause a ... |
DB00813 | DB06372 | 704 | 259 | [
"DDInter722",
"DDInter1594"
] | Fentanyl | Rilonacept | Fentanyl, a potent opioid agonist, was developed in the 1950s to fill a need for strong and rapid analgesia. Because of these characteristics, fentanyl is commonly used to treat chronic cancer pain or in anesthesia.[Label,L6598,L6601,L6604,L6607,L922,L6610,L6613] Fentanyl is related to other opioids like [morphine] and... | Rilonacept is a dimeric fusion protein consisting of portions of IL-1R and the IL-1R accessory protein linked to the Fc portion of immunoglobulin G1. Rilonacept functions as an interleukin 1 inhibitor and is used in the treatment of CAPS, also known as cryopyrin-associated periodic syndromes, including familial cold au... | Moderate | 1 | [
[
[
704,
24,
259
]
],
[
[
704,
24,
1619
],
[
1619,
63,
259
]
],
[
[
704,
40,
1454
],
[
1454,
24,
259
]
],
[
[
704,
25,
478
],
[
478,
... | [
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rilonacept"
]
],
[
[
"Fentanyl",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rucaparib"
],
[
"... | Fentanyl may cause a moderate interaction that could exacerbate diseases when taken with Rucaparib and Rucaparib may cause a moderate interaction that could exacerbate diseases when taken with Rilonacept
Fentanyl (Compound) resembles Sufentanil (Compound) and Sufentanil may cause a moderate interaction that could exace... |
DB00342 | DB01255 | 1,181 | 633 | [
"DDInter1770",
"DDInter1078"
] | Terfenadine | Lisdexamfetamine | In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation. | Lisdexamfetamine is a prodrug of [dextroamphetamine], a central nervous system stimulant known as d-amphetamine, covalently attached to the naturally occurring amino acid L-lysine. Lisdexamfetamine is the first chemically formulated prodrug stimulant and was first approved by the FDA in April 2008. It was also approved... | Moderate | 1 | [
[
[
1181,
24,
633
]
],
[
[
1181,
23,
112
],
[
112,
23,
633
]
],
[
[
1181,
24,
1494
],
[
1494,
24,
633
]
],
[
[
1181,
24,
286
],
[
286,
... | [
[
[
"Terfenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lisdexamfetamine"
]
],
[
[
"Terfenadine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],... | Terfenadine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Lisdexamfetamine
Terfenadine may cause a moderate interaction that could exacerbate diseases when taken with Palonosetro... |
DB00747 | DB01085 | 1,442 | 562 | [
"DDInter1647",
"DDInter1465"
] | Scopolamine | Pilocarpine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | A naturally occurring alkaloid derived from the _Pilocarpus_ plants, pilocarpine is a muscarinic acetylcholine agonist.[A262016, A262036] Pilocarpine is associated with parasympathomimetic effects by selectively working on muscarinic receptors. Pilocarpine is used to treat dry mouth and various ophthalmic conditions, i... | Moderate | 1 | [
[
[
1442,
24,
562
]
],
[
[
1442,
6,
7992
],
[
7992,
45,
562
]
],
[
[
1442,
21,
28847
],
[
28847,
60,
562
]
],
[
[
1442,
24,
1507
],
[
1507... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pilocarpine"
]
],
[
[
"Scopolamine",
"{u} (Compound) binds {v} (Gene)",
"CHRM1"
],
[
"CHRM1",
"{u} (Gene) is bound by {v} (Compound)"... | Scopolamine (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Pilocarpine (Compound)
Scopolamine (Compound) causes Eye disorder (Side Effect) and Eye disorder (Side Effect) is caused by Pilocarpine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Dicyclomin... |
DB00099 | DB15965 | 440 | 1,330 | [
"DDInter735",
"DDInter1270"
] | Filgrastim | Naxitamab | Filgrastim is a short-acting recombinant, non-pegylated human granulocyte colony-stimulating factor (G-CSF) analog produced by recombinant DNA technology. It has an amino acid sequence identical to endogenous G-CSF, but it is non-glycosylated unlike the endogenous G-CSF and has an N-terminal methionine added in the seq... | Naxitamab (humanized 3F8, hu3F8) is an IgG1 monoclonal antibody directed against the oncofetal differentiation antigen GD2 disialoganglioside.[L24454,A224604] Normally expressed during fetal development and in mature neurons, pain fibers, and skin cells, GD2 constitutes a highly efficient target in the treatment of neu... | Moderate | 1 | [
[
[
440,
24,
1330
]
],
[
[
440,
24,
1532
],
[
1532,
24,
1330
]
],
[
[
440,
63,
268
],
[
268,
24,
1330
]
],
[
[
440,
25,
1064
],
[
1064,
... | [
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naxitamab"
]
],
[
[
"Filgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ifosfamide"
],
[
... | Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Ifosfamide and Ifosfamide may cause a moderate interaction that could exacerbate diseases when taken with Naxitamab
Filgrastim may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon alfa-2b ... |
DB00211 | DB09065 | 1,290 | 760 | [
"DDInter1213",
"DDInter424"
] | Midodrine | Cobicistat | An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Moderate | 1 | [
[
[
1290,
24,
760
]
],
[
[
1290,
24,
1374
],
[
1374,
23,
760
]
],
[
[
1290,
24,
868
],
[
868,
24,
760
]
],
[
[
1290,
24,
659
],
[
659,
... | [
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cobicistat"
]
],
[
[
"Midodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abiraterone"
],
[
... | Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Midodrine may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vemuraf... |
DB00580 | DB12364 | 311 | 1,421 | [
"DDInter1910",
"DDInter200"
] | Valdecoxib | Betrixaban | Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke. | Betrixaban is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa . It was selected among all lead compounds due to its low hERG channel affinity while sustaining its factor Xa inhibition capacity . Betrixaban, now developed by Portola Pharmaceuticals ... | Moderate | 1 | [
[
[
311,
24,
1421
]
],
[
[
311,
24,
1017
],
[
1017,
24,
1421
]
],
[
[
311,
63,
305
],
[
305,
24,
1421
]
],
[
[
311,
24,
714
],
[
714,
... | [
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betrixaban"
]
],
[
[
"Valdecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
... | Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Betrixaban
Valdecoxib may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Escheric... |
DB11703 | DB12887 | 405 | 1,598 | [
"DDInter9",
"DDInter1750"
] | Acalabrutinib | Tazemetostat | To date, acalabrutinib has been used in trials studying the treatment of B-All, myelofibrosis, ovarian cancer, multiple myeloma, and Hodgkin lymphoma, among others. As of October 31, 2017 the FDA approved Astra Zeneca's orally administered Calquence (acalabrutinib, capsules). This Bruton tyrosine kinase (BTK) inhibitor... | Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. Tazemetostat was first named in literature as EPZ-6438. Tazemetaostat was granted FDA approval on 23 January 2020. | Moderate | 1 | [
[
[
405,
24,
1598
]
],
[
[
405,
24,
738
],
[
738,
24,
1598
]
],
[
[
405,
63,
1039
],
[
1039,
24,
1598
]
],
[
[
405,
64,
578
],
[
578,
... | [
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tazemetostat"
]
],
[
[
"Acalabrutinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Niraparib"
],
... | Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Niraparib and Niraparib may cause a moderate interaction that could exacerbate diseases when taken with Tazemetostat
Acalabrutinib may cause a moderate interaction that could exacerbate diseases when taken with Dexfenfluramine... |
DB00533 | DB09133 | 1,416 | 1,527 | [
"DDInter1613",
"DDInter965"
] | Rofecoxib | Iothalamic acid | Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid. This compound belongs to the stilbenes. These are organic compounds containing a 1,2-diphenylethylene m... | Iothalamic acid is an iodine containing organic anion used as a diagnostic contrast agent. | Major | 2 | [
[
[
1416,
25,
1527
]
],
[
[
1416,
63,
91
],
[
91,
25,
1527
]
],
[
[
1416,
24,
1512
],
[
1512,
25,
1527
]
],
[
[
1416,
25,
629
],
[
629,
... | [
[
[
"Rofecoxib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iothalamic acid"
]
],
[
[
"Rofecoxib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vancomycin"
],
[
"Vancomy... | Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Vancomycin and Vancomycin may lead to a major life threatening interaction when taken with Iothalamic acid
Rofecoxib may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may lea... |
DB09272 | DB13913 | 412 | 1,536 | [
"DDInter632",
"DDInter175"
] | Eluxadoline | Belladonna | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Moderate | 1 | [
[
[
412,
24,
1536
]
],
[
[
412,
63,
849
],
[
849,
24,
1536
]
],
[
[
412,
24,
407
],
[
407,
24,
1536
]
],
[
[
412,
63,
849
],
[
849,
... | [
[
[
"Eluxadoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Belladonna"
]
],
[
[
"Eluxadoline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
[
... | Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Eluxadoline may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may... |
DB01142 | DB06204 | 1,264 | 768 | [
"DDInter593",
"DDInter1746"
] | Doxepin | Tapentadol | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Tapentadol is a centrally-acting synthetic analgesic with a dual mechanism of action. It is a mu-opioid receptor agonist that also inhibits norepinephrine reuptake.[A260721, A36596] Tapentadol was first approved by the FDA on November 20, 2008. The extended-release formulation of tapentadol was also approved by the FDA... | Major | 2 | [
[
[
1264,
25,
768
]
],
[
[
1264,
6,
10215
],
[
10215,
45,
768
]
],
[
[
1264,
21,
29332
],
[
29332,
60,
768
]
],
[
[
1264,
63,
1123
],
[
11... | [
[
[
"Doxepin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tapentadol"
]
],
[
[
"Doxepin",
"{u} (Compound) binds {v} (Gene)",
"CYP2C19"
],
[
"CYP2C19",
"{u} (Gene) is bound by {v} (Compound)",
"Tapentadol"... | Doxepin (Compound) binds CYP2C19 (Gene) and CYP2C19 (Gene) is bound by Tapentadol (Compound)
Doxepin (Compound) causes Drug withdrawal syndrome (Side Effect) and Drug withdrawal syndrome (Side Effect) is caused by Tapentadol (Compound)
Doxepin may cause a moderate interaction that could exacerbate diseases when taken w... |
DB08816 | DB11718 | 578 | 927 | [
"DDInter1802",
"DDInter640"
] | Ticagrelor | Encorafenib | Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism. Unlike [clopidogrel], ticagrelor is not a prodrug. It is marketed by Astra Zeneca as Brilinta in the US and Brilique or Possia in the EU,. Ticagre... | Encorafenib, also known as _BRAFTOVI_, is a kinase inhibitor. Encorafenib inhibits BRAF gene, which encodes for B-raf protein, which is a proto-oncogene involved in various genetic mutations. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which impacts cell division, differentiation, and ... | Moderate | 1 | [
[
[
578,
24,
927
]
],
[
[
578,
63,
536
],
[
536,
24,
927
]
],
[
[
578,
62,
84
],
[
84,
24,
927
]
],
[
[
578,
24,
484
],
[
484,
63,
... | [
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Encorafenib"
]
],
[
[
"Ticagrelor",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Secobarbital"
],
[... | Ticagrelor may cause a moderate interaction that could exacerbate diseases when taken with Secobarbital and Secobarbital may cause a moderate interaction that could exacerbate diseases when taken with Encorafenib
Ticagrelor may cause a minor interaction that can limit clinical effects when taken with Nisoldipine and Ni... |
DB00512 | DB01082 | 91 | 1,448 | [
"DDInter1916",
"DDInter1713"
] | Vancomycin | Streptomycin | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
91,
24,
1448
]
],
[
[
91,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
91,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
91,
24,
1332
],
[
1332,
... | [
[
[
"Vancomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Vancomycin",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound by {v} (Compoun... | Vancomycin (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Vancomycin (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Vancomycin may cause a moderate interaction that could exacerbate diseases when taken with Metho... |
DB00321 | DB01612 | 21 | 1,637 | [
"DDInter78",
"DDInter92"
] | Amitriptyline | Amyl Nitrite | Amitriptyline is a tricyclic antidepressant that has been used to treat depression for decades. ELAVIL, a previously approved branded product of amitriptyline, was first approved by the FDA in 1961. Amitriptyline has been investigated in the treatment of pain-related conditions, attributed to its analgesic properties. | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Its use as a prescription medicine comes from its ability to lower blood pressure. As an inhalant, it also has psychoactive effect which has led to illegal drug use. | Moderate | 1 | [
[
[
21,
24,
1637
]
],
[
[
21,
1,
358
],
[
358,
24,
1637
]
],
[
[
21,
63,
475
],
[
475,
24,
1637
]
],
[
[
21,
35,
401
],
[
401,
24,
... | [
[
[
"Amitriptyline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amyl Nitrite"
]
],
[
[
"Amitriptyline",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{u} may cau... | Amitriptyline (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Amyl Nitrite
Amitriptyline may cause a moderate interaction that could exacerbate diseases when taken with Morphine and Morphine may cause a moderate interaction th... |
DB01124 | DB09104 | 1,411 | 286 | [
"DDInter1828",
"DDInter1118"
] | Tolbutamide | Magnesium hydroxide | Tolbutamide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It is structurally similar to acetohexamide, chlorpropamide and tolazamide and belongs to the sulfonylurea class of insulin secretagogues, which act by stimulating β cells of the pancreas to release... | Magnesium hydroxide is an inorganic compound. It is naturally found as the mineral brucite. Magnesium hydroxide can be used as an antacid or a laxative in either an oral liquid suspension or chewable tablet form. Additionally, magnesium hydroxide has smoke suppressing and flame retardant properties and is thus used com... | Moderate | 1 | [
[
[
1411,
24,
286
]
],
[
[
1411,
24,
820
],
[
820,
23,
286
]
],
[
[
1411,
63,
401
],
[
401,
23,
286
]
],
[
[
1411,
62,
556
],
[
556,
... | [
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium hydroxide"
]
],
[
[
"Tolbutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine may cause a minor interaction that can limit clinical effects when taken with Magnesium hydroxide
Tolbutamide may cause a moderate interaction that could exacerbate diseases when taken with Promethazi... |
DB01215 | DB04837 | 1,418 | 649 | [
"DDInter677",
"DDInter407"
] | Estazolam | Clofedanol | A benzodiazepine with anticonvulsant, hypnotic, and muscle relaxant properties. It has been shown in some cases to be more potent than diazepam or nitrazepam. | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
1418,
24,
649
]
],
[
[
1418,
63,
1376
],
[
1376,
24,
649
]
],
[
[
1418,
63,
832
],
[
832,
40,
649
]
],
[
[
1418,
24,
820
],
[
820,
... | [
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Estazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Estazolam may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamin... |
DB00761 | DB13913 | 1,621 | 1,536 | [
"DDInter1497",
"DDInter175"
] | Potassium chloride | Belladonna | A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives. The FDA withdrew its approval for the use of all solid oral dosage form drug products containing potassium chloride that supply 100 mg or more of potassium p... | Belladonna, also known as atropa belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family _Solanaceae_. Its roots, leaves and fruits contain , , and mostly, . These alkaloids are naturally-occurring muscarinic antagonists. is a non-selective muscarinic antagonist that is mainly used as ... | Major | 2 | [
[
[
1621,
25,
1536
]
],
[
[
1621,
25,
849
],
[
849,
24,
1536
]
],
[
[
1621,
64,
128
],
[
128,
24,
1536
]
],
[
[
1621,
25,
849
],
[
849,
... | [
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Belladonna"
]
],
[
[
"Potassium chloride",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mepyramine"
],
[
"Mepyramin... | Potassium chloride may lead to a major life threatening interaction when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Belladonna
Potassium chloride may lead to a major life threatening interaction when taken with Dexbrompheniramine and Dexbrompheni... |
DB00719 | DB01202 | 1,219 | 1,435 | [
"DDInter149",
"DDInter1046"
] | Azatadine | Levetiracetam | Antihistamines such as azatadine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue inj... | Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs).[L8606,L8600,L8615] Levetiracetam poss... | Moderate | 1 | [
[
[
1219,
24,
1435
]
],
[
[
1219,
63,
701
],
[
701,
24,
1435
]
],
[
[
1219,
24,
1376
],
[
1376,
24,
1435
]
],
[
[
1219,
24,
1311
],
[
1311... | [
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levetiracetam"
]
],
[
[
"Azatadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
[
... | Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Levetiracetam
Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and ... |
DB00230 | DB00358 | 784 | 1,010 | [
"DDInter1516",
"DDInter1140"
] | Pregabalin | Mefloquine | Pregabalin is structurally similar to gamma-aminobutyric acid (GABA) - an inhibitory neurotransmitter. It may be used to manage neuropathic pain, postherpetic neuralgia, and fibromyalgia among other conditions. Although as per the FDA Label the mechanism of action has not been definitively characterized, there is evide... | Malaria is a protozoan disease that places an enormous burden on human health in endemic areas around the world. The 2020 World Health Organization malaria report indicates a 60% decrease in the global malaria fatality rate between 2000 to 2019. Despite this, malaria remains a significant cause of morbidity and mortali... | Moderate | 1 | [
[
[
784,
24,
1010
]
],
[
[
784,
21,
29362
],
[
29362,
60,
1010
]
],
[
[
784,
24,
1311
],
[
1311,
62,
1010
]
],
[
[
784,
24,
401
],
[
401,
... | [
[
[
"Pregabalin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mefloquine"
]
],
[
[
"Pregabalin",
"{u} (Compound) causes {v} (Side Effect)",
"Leukocytosis"
],
[
"Leukocytosis",
"{u} (Side Effect) i... | Pregabalin (Compound) causes Leukocytosis (Side Effect) and Leukocytosis (Side Effect) is caused by Mefloquine (Compound)
Pregabalin may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a minor interaction that can limit clinical effects when taken ... |
DB00545 | DB04843 | 751 | 1,511 | [
"DDInter1548",
"DDInter1149"
] | Pyridostigmine | Mepenzolate | Myasthenia gravis is an autoimmune disease involving dysfunction at the neuromuscular junction, most commonly due to autoantibodies directed against the acetylcholine receptor (AChR), which results in muscle tone loss, muscle weakness, and fatigue. Acetylcholinesterase inhibitors have been the symptomatic treatment of ... | Mepenzolate is a post-ganglionic parasympathetic inhibitor. It decreases gastric acid and pepsin secretion and suppresses spontaneous contractions of the colon. Mepenzolate diminishes gastric acid and pepsin secretion. Mepenzolate also suppresses spontaneous contractions of the colon. Pharmacologically, it is a post-ga... | Moderate | 1 | [
[
[
751,
24,
1511
]
],
[
[
751,
24,
1192
],
[
1192,
24,
1511
]
],
[
[
751,
63,
352
],
[
352,
24,
1511
]
],
[
[
751,
21,
28722
],
[
28722,
... | [
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepenzolate"
]
],
[
[
"Pyridostigmine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glycopyrronium"
... | Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Glycopyrronium and Glycopyrronium may cause a moderate interaction that could exacerbate diseases when taken with Mepenzolate
Pyridostigmine may cause a moderate interaction that could exacerbate diseases when taken with Tros... |
DB01162 | DB01284 | 195 | 1,042 | [
"DDInter1767",
"DDInter1782"
] | Terazosin | Tetracosactide | Terazosin is a quinazoline derivative alpha-1-selective adrenergic blocking agent indicated for benign prostatic hyperplasia and hypertension[FDA Label]. Terazosin blocks adrenaline's action on alpha-1 adrenergic receptors, causing relaxation of smooth muscle in blood vessels and the prostate. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
195,
24,
1042
]
],
[
[
195,
24,
1450
],
[
1450,
63,
1042
]
],
[
[
195,
63,
1648
],
[
1648,
24,
1042
]
],
[
[
195,
1,
1433
],
[
1433,
... | [
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Terazosin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Empagliflozin"
],
... | Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and Empagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Tetracosactide
Terazosin may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin a... |
DB00215 | DB08871 | 1,230 | 36 | [
"DDInter388",
"DDInter666"
] | Citalopram | Eribulin | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Major | 2 | [
[
[
1230,
25,
36
]
],
[
[
1230,
25,
1424
],
[
1424,
24,
36
]
],
[
[
1230,
62,
168
],
[
168,
24,
36
]
],
[
[
1230,
64,
600
],
[
600,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Eribulin"
]
],
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Quinine"
],
[
"Quinine",
"{u} may cause... | Citalopram may lead to a major life threatening interaction when taken with Quinine and Quinine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Citalopram may cause a minor interaction that can limit clinical effects when taken with Bortezomib and Bortezomib may cause a moderate... |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.