drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00700 | DB00860 | 312 | 891 | [
"DDInter656",
"DDInter1513"
] | Eplerenone | Prednisolone | Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone c... | Prednisolone is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects. Prednisolone was granted FDA approval on 21 June 1955. | Moderate | 1 | [
[
[
312,
24,
891
]
],
[
[
312,
1,
11347
],
[
11347,
40,
891
]
],
[
[
312,
40,
989
],
[
989,
1,
891
]
],
[
[
312,
63,
175
],
[
175,
4... | [
[
[
"Eplerenone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisolone"
]
],
[
[
"Eplerenone",
"{u} (Compound) resembles {v} (Compound)",
"Hydrocortamate"
],
[
"Hydrocortamate",
"{u} (Compound... | Eplerenone (Compound) resembles Hydrocortamate (Compound) and Hydrocortamate (Compound) resembles Prednisolone (Compound)
Eplerenone (Compound) resembles Progesterone (Compound) and Progesterone (Compound) resembles Prednisolone (Compound)
Eplerenone may cause a moderate interaction that could exacerbate diseases when ... |
DB00671 | DB00798 | 778 | 1,132 | [
"DDInter319",
"DDInter815"
] | Cefixime | Gentamicin | Bacteria possess a cell wall comprising a glycopeptide polymer commonly known as peptidoglycan, which is synthesized and remodelled through the action of a family of enzymes known as "penicillin-binding proteins" (PBPs). β-lactam antibiotics, including cephalosporins, are PBP inhibitors that, through inhibition of esse... | Gentamicin is a bactericidal aminoglycoside that was discovered and isolated from _Micromonospora purpurea_ in 1963. It is one of the most frequently prescribed aminoglycosides due to its spectrum of activity, low cost, and availability.[A234339,A234354] Gentamicin is effective against both gram-positive and gram-negat... | Moderate | 1 | [
[
[
778,
24,
1132
]
],
[
[
778,
18,
10375
],
[
10375,
57,
1132
]
],
[
[
778,
21,
28703
],
[
28703,
60,
1132
]
],
[
[
778,
24,
361
],
[
361... | [
[
[
"Cefixime",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gentamicin"
]
],
[
[
"Cefixime",
"{u} (Compound) downregulates {v} (Gene)",
"RPS4Y1"
],
[
"RPS4Y1",
"{u} (Gene) is downregulated by {v} ... | Cefixime (Compound) downregulates RPS4Y1 (Gene) and RPS4Y1 (Gene) is downregulated by Gentamicin (Compound)
Cefixime (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Gentamicin (Compound)
Cefixime may cause a moderate interaction that could exacerbate diseases when taken with Neomycin an... |
DB00218 | DB06176 | 1,176 | 1,342 | [
"DDInter1247",
"DDInter1616"
] | Moxifloxacin | Romidepsin | Moxifloxacin is a synthetic fluoroquinolone antibiotic agent. Bayer AG developed the drug (initially called BAY 12-8039) and it is marketed worldwide (as the hydrochloride) under the brand name Avelox (in some countries also Avalox) for oral treatment. | Romidepsin is a selective inhibitor of histone deacetylase, approved in the US in 2009 for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have received at least one prior systemic therapy. | Major | 2 | [
[
[
1176,
25,
1342
]
],
[
[
1176,
23,
112
],
[
112,
23,
1342
]
],
[
[
1176,
1,
956
],
[
956,
24,
1342
]
],
[
[
1176,
25,
485
],
[
485,
... | [
[
[
"Moxifloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Romidepsin"
]
],
[
[
"Moxifloxacin",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metro... | Moxifloxacin may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Romidepsin
Moxifloxacin (Compound) resembles Norfloxacin (Compound) and Norfloxacin may cause a moderate interaction th... |
DB00367 | DB11986 | 566 | 484 | [
"DDInter1061",
"DDInter648"
] | Levonorgestrel | Entrectinib | Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of ... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Moderate | 1 | [
[
[
566,
24,
484
]
],
[
[
566,
40,
1197
],
[
1197,
24,
484
]
],
[
[
566,
24,
1320
],
[
1320,
24,
484
]
],
[
[
566,
25,
927
],
[
927,
... | [
[
[
"Levonorgestrel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Entrectinib"
]
],
[
[
"Levonorgestrel",
"{u} (Compound) resembles {v} (Compound)",
"Norethisterone"
],
[
"Norethisterone",
"{u} ma... | Levonorgestrel (Compound) resembles Norethisterone (Compound) and Norethisterone may cause a moderate interaction that could exacerbate diseases when taken with Entrectinib
Levonorgestrel may cause a moderate interaction that could exacerbate diseases when taken with Elagolix and Elagolix may cause a moderate interacti... |
DB00924 | DB09472 | 1,405 | 1,383 | [
"DDInter454",
"DDInter1693"
] | Cyclobenzaprine | Sodium sulfate | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1405,
24,
1383
]
],
[
[
1405,
24,
1311
],
[
1311,
24,
1383
]
],
[
[
1405,
63,
104
],
[
104,
24,
1383
]
],
[
[
1405,
25,
1264
],
[
1264... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metoclopramid... | Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Metoclopramide and Metoclopramide may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with... |
DB01076 | DB14568 | 700 | 982 | [
"DDInter133",
"DDInter1000"
] | Atorvastatin | Ivosidenib | Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competi... | Ivosidenib is a first-in-class isocitrate dehydrogenase-1 (IDH1) inhibitor. IDH1 is an enzyme that is often mutated and overexpressed in some cancers, leading to aberrant cell growth and proliferation. Ivosidenib inhibits mutated IDH1, blocking the enzymatic activity and further differentiation of cancer cells. Ivoside... | Moderate | 1 | [
[
[
700,
24,
982
]
],
[
[
700,
63,
112
],
[
112,
23,
982
]
],
[
[
700,
63,
770
],
[
770,
24,
982
]
],
[
[
700,
24,
1478
],
[
1478,
2... | [
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivosidenib"
]
],
[
[
"Atorvastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
... | Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Ivosidenib
Atorvastatin may cause a moderate interaction that could exacerbate diseases when taken with Thalidomide a... |
DB01115 | DB06674 | 336 | 908 | [
"DDInter1291",
"DDInter837"
] | Nifedipine | Golimumab | Nifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine].[A190210,A190273,A175390,L11383] Nifedipine was developed by Bayer and first described in the literature, along with other dihydropyridines, in 1972.[A175390,A190276] Since nifedipine's development,... | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Moderate | 1 | [
[
[
336,
24,
908
]
],
[
[
336,
40,
84
],
[
84,
24,
908
]
],
[
[
336,
63,
467
],
[
467,
24,
908
]
],
[
[
336,
62,
1031
],
[
1031,
24,... | [
[
[
"Nifedipine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Golimumab"
]
],
[
[
"Nifedipine",
"{u} (Compound) resembles {v} (Compound)",
"Nisoldipine"
],
[
"Nisoldipine",
"{u} may cause a modera... | Nifedipine (Compound) resembles Nisoldipine (Compound) and Nisoldipine may cause a moderate interaction that could exacerbate diseases when taken with Golimumab
Nifedipine may cause a moderate interaction that could exacerbate diseases when taken with Simvastatin and Simvastatin may cause a moderate interaction that co... |
DB09065 | DB11642 | 760 | 938 | [
"DDInter424",
"DDInter1480"
] | Cobicistat | Pitolisant | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Pitolisant is a selective antagonist or inverse agonist of the histamine H3 receptor used to treat type 1 or 2 narcolepsy. Narcolepsy is a chronic neurological disorder that affects 1 in 2,000 individuals and is characterized by excessive daytime sleepiness, abnormal REM sleep manifestations, sleep paralysis and hypnag... | Moderate | 1 | [
[
[
760,
24,
938
]
],
[
[
760,
63,
600
],
[
600,
24,
938
]
],
[
[
760,
25,
927
],
[
927,
63,
938
]
],
[
[
760,
64,
617
],
[
617,
24,... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pitolisant"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluconazole"
],
[
... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Fluconazole and Fluconazole may cause a moderate interaction that could exacerbate diseases when taken with Pitolisant
Cobicistat may lead to a major life threatening interaction when taken with Encorafenib and Encorafenib may ca... |
DB00095 | DB00307 | 66 | 1,101 | [
"DDInter623",
"DDInter202"
] | Efalizumab | Bexarotene | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma. | Moderate | 1 | [
[
[
66,
24,
1101
]
],
[
[
66,
24,
1419
],
[
1419,
62,
1101
]
],
[
[
66,
24,
168
],
[
168,
23,
1101
]
],
[
[
66,
24,
287
],
[
287,
63... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a minor interaction that can limit clinical effects when taken with Bexarotene
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib m... |
DB00189 | DB01142 | 459 | 1,264 | [
"DDInter691",
"DDInter593"
] | Ethchlorvynol | Doxepin | Ethchlorvynol is a sedative and hypnotic drug. It has been used to treat insomnia, but has been largely superseded and is only offered where an intolerance or allergy to other drugs exists. | Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. In a strict sense, doxepin is not a tricyclic antidepr... | Moderate | 1 | [
[
[
459,
24,
1264
]
],
[
[
459,
24,
1594
],
[
1594,
24,
1264
]
],
[
[
459,
24,
649
],
[
649,
63,
1264
]
],
[
[
459,
63,
1648
],
[
1648,
... | [
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxepin"
]
],
[
[
"Ethchlorvynol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
],
[... | Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Doxepin
Ethchlorvynol may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol and Clo... |
DB01017 | DB01309 | 1,669 | 1,254 | [
"DDInter1224",
"DDInter933"
] | Minocycline | Insulin glulisine | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Insulin glulisine is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is typically prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas... | Moderate | 1 | [
[
[
1669,
24,
1254
]
],
[
[
1669,
1,
1545
],
[
1545,
24,
1254
]
],
[
[
1669,
40,
964
],
[
964,
24,
1254
]
],
[
[
1669,
24,
266
],
[
266,
... | [
[
[
"Minocycline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Insulin glulisine"
]
],
[
[
"Minocycline",
"{u} (Compound) resembles {v} (Compound)",
"Oxytetracycline"
],
[
"Oxytetracycline",
"{u} ... | Minocycline (Compound) resembles Oxytetracycline (Compound) and Oxytetracycline may cause a moderate interaction that could exacerbate diseases when taken with Insulin glulisine
Minocycline (Compound) resembles Doxycycline (Compound) and Doxycycline may cause a moderate interaction that could exacerbate diseases when t... |
DB00227 | DB08871 | 1,463 | 36 | [
"DDInter1098",
"DDInter666"
] | Lovastatin | Eribulin | Lovastatin, also known as the brand name product Mevacor, is a lipid-lowering drug and fungal metabolite derived synthetically from a fermentation product of _Aspergillus terreus_. Originally named Mevinolin, lovastatin belongs to the statin class of medications, which are used to lower the risk of cardiovascular disea... | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1463,
24,
36
]
],
[
[
1463,
24,
1488
],
[
1488,
24,
36
]
],
[
[
1463,
63,
168
],
[
168,
24,
36
]
],
[
[
1463,
25,
609
],
[
609,
... | [
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Lovastatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Lovastatin may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortez... |
DB00495 | DB09498 | 139 | 810 | [
"DDInter1961",
"DDInter1715"
] | Zidovudine | Strontium chloride Sr-89 | A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain... | Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer. Bone metastases is a common and severe complication presented in advanced stag... | Moderate | 1 | [
[
[
139,
24,
810
]
],
[
[
139,
63,
552
],
[
552,
24,
810
]
],
[
[
139,
24,
1555
],
[
1555,
24,
810
]
],
[
[
139,
74,
141
],
[
141,
2... | [
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Strontium chloride Sr-89"
]
],
[
[
"Zidovudine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carmustine"
... | Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Carmustine and Carmustine may cause a moderate interaction that could exacerbate diseases when taken with Strontium chloride Sr-89
Zidovudine may cause a moderate interaction that could exacerbate diseases when taken with Oxalipl... |
DB06077 | DB11979 | 879 | 1,320 | [
"DDInter1102",
"DDInter625"
] | Lumateperone | Elagolix | Schizophrenia is a complex mental illness and impacts approximately 1% of the population. Although there are several antipsychotics including [aripiprazole], [paliperidone] and [clozapine] available for clinical use, they are generally accompanied by significant metabolic and/or neurological adverse effects. Lumatepero... | Elagolix has been used in trials studying the basic science and treatment of Endometriosis, Folliculogenesis, Uterine Fibroids, Heavy Uterine Bleeding, and Heavy Menstrual Bleeding. As of 24 July 2018, however, the U.S. Food and Drug Administration (FDA) approved AbbVie's elagolix under the brand name Orilissa as the f... | Major | 2 | [
[
[
879,
25,
1320
]
],
[
[
879,
63,
79
],
[
79,
24,
1320
]
],
[
[
879,
25,
129
],
[
129,
24,
1320
]
],
[
[
879,
24,
1281
],
[
1281,
... | [
[
[
"Lumateperone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Elagolix"
]
],
[
[
"Lumateperone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sorafenib"
],
[
"Sorafenib... | Lumateperone may cause a moderate interaction that could exacerbate diseases when taken with Sorafenib and Sorafenib may cause a moderate interaction that could exacerbate diseases when taken with Elagolix
Lumateperone may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may ca... |
DB00448 | DB05541 | 1,215 | 801 | [
"DDInter1022",
"DDInter239"
] | Lansoprazole | Brivaracetam | Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole. It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux ... | Brivaracetam is a racetam derivative of levetiracetam used in the treatment of partial-onset seizures. Brivaracetam binds SV2A with 20 times higher affinity than levetiracetam . It is available under the brand name Briviact made by UCB. Briviact received FDA approval on February 19, 2016 . | Minor | 0 | [
[
[
1215,
23,
801
]
],
[
[
1215,
25,
477
],
[
477,
23,
801
]
],
[
[
1215,
40,
660
],
[
660,
23,
801
]
],
[
[
1215,
24,
126
],
[
126,
... | [
[
[
"Lansoprazole",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Brivaracetam"
]
],
[
[
"Lansoprazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cilostazol"
],
[
"Cilost... | Lansoprazole may lead to a major life threatening interaction when taken with Cilostazol and Cilostazol may cause a minor interaction that can limit clinical effects when taken with Brivaracetam
Lansoprazole (Compound) resembles Esomeprazole (Compound) and Esomeprazole may cause a minor interaction that can limit clini... |
DB00909 | DB01246 | 306 | 820 | [
"DDInter1971",
"DDInter45"
] | Zonisamide | Alimemazine | Zonisamide is a sulfonamide anticonvulsant used as an adjunctive therapy in adults with partial-onset seizures.[L42530,L42535] Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels, leading to a reduction of T-type calcium channel currents or by binding allosterically to GABA receptors. This... | A phenothiazine derivative that is used as an antipruritic. | Major | 2 | [
[
[
306,
25,
820
]
],
[
[
306,
64,
104
],
[
104,
40,
820
]
],
[
[
306,
25,
401
],
[
401,
24,
820
]
],
[
[
306,
24,
649
],
[
649,
1,
... | [
[
[
"Zonisamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Alimemazine"
]
],
[
[
"Zonisamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methdilazine"
],
[
"Methdilazine",
"... | Zonisamide may lead to a major life threatening interaction when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (Compound)
Zonisamide may lead to a major life threatening interaction when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases ... |
DB10583 | DB11834 | 949 | 1,303 | [
"DDInter415",
"DDInter849"
] | Clostridium tetani toxoid antigen (formaldehyde inactivated) | Guselkumab | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation . In clinical trials, guselkumab demonstra... | Moderate | 1 | [
[
[
949,
24,
1303
]
],
[
[
949,
63,
713
],
[
713,
24,
1303
]
],
[
[
949,
24,
270
],
[
270,
63,
1303
]
],
[
[
949,
24,
1456
],
[
1456,
... | [
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Guselkumab"
]
],
[
[
"Clostridium tetani toxoid antigen (formaldehyde inactivated)",
"{u} may cause a moderate... | Clostridium tetani toxoid antigen (formaldehyde inactivated) may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumarate and Dimethyl fumarate may cause a moderate interaction that could exacerbate diseases when taken with Guselkumab
Clostridium tetani toxoid antigen (formaldehyde ... |
DB00352 | DB08820 | 482 | 1,478 | [
"DDInter1814",
"DDInter997"
] | Tioguanine | Ivacaftor | An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia. | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
482,
24,
1478
]
],
[
[
482,
21,
28722
],
[
28722,
60,
1478
]
],
[
[
482,
24,
1398
],
[
1398,
63,
1478
]
],
[
[
482,
24,
866
],
[
866,
... | [
[
[
"Tioguanine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Tioguanine",
"{u} (Compound) causes {v} (Side Effect)",
"Nausea"
],
[
"Nausea",
"{u} (Side Effect) is caused by {... | Tioguanine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Ivacaftor (Compound)
Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Macitentan and Macitentan may cause a moderate interaction that could exacerbate diseases when taken with Ivacaftor
Tiog... |
DB00108 | DB15699 | 1,066 | 652 | [
"DDInter1268",
"DDInter232"
] | Natalizumab | Brexucabtagene autoleucel | Natalizumab is a recombinant humanized IgG4κ monoclonal antibody that binds to α4-integrin. While natalizumab was originally approved by the FDA to treat multiple sclerosis in 2004, it was withdrawn from the market following multiple reports of fatal progressive multifocal leukoencephalopathy (PML). In 2006, the FDA re... | Mantle cell lymphoma is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. Despite the introduction of Bruton's tyrosine kinase (BTK) inhibitors such as [ibrutinib] and [acalabrutinib], the prognosis for MCL patients rem... | Major | 2 | [
[
[
1066,
25,
652
]
],
[
[
1066,
25,
259
],
[
259,
24,
652
]
],
[
[
1066,
24,
1430
],
[
1430,
24,
652
]
],
[
[
1066,
64,
1184
],
[
1184,
... | [
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brexucabtagene autoleucel"
]
],
[
[
"Natalizumab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Rilonacept"
],
[
"Rilonace... | Natalizumab may lead to a major life threatening interaction when taken with Rilonacept and Rilonacept may cause a moderate interaction that could exacerbate diseases when taken with Brexucabtagene autoleucel
Natalizumab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Si... |
DB00431 | DB00981 | 1,503 | 1,528 | [
"DDInter1072",
"DDInter1462"
] | Lindane | Physostigmine | An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due ... | A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity. | Moderate | 1 | [
[
[
1503,
24,
1528
]
],
[
[
1503,
21,
28751
],
[
28751,
60,
1528
]
],
[
[
1503,
63,
508
],
[
508,
24,
1528
]
],
[
[
1503,
24,
87
],
[
87,
... | [
[
[
"Lindane",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Physostigmine"
]
],
[
[
"Lindane",
"{u} (Compound) causes {v} (Side Effect)",
"Convulsion"
],
[
"Convulsion",
"{u} (Side Effect) is cause... | Lindane (Compound) causes Convulsion (Side Effect) and Convulsion (Side Effect) is caused by Physostigmine (Compound)
Lindane may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine may cause a moderate interaction that could exacerbate diseases when taken with Physostigm... |
DB00486 | DB00519 | 1,614 | 1,638 | [
"DDInter1253",
"DDInter1843"
] | Nabilone | Trandolapril | Nabilone (marketed as Cesamet) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). Although structurally distinct from THC, nabilone mimics THC's structure and pharmacological activity through weak partial agonist activity at Cannabinoid-1 (CB1R) and... | Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiote... | Moderate | 1 | [
[
[
1614,
24,
1638
]
],
[
[
1614,
24,
954
],
[
954,
40,
1638
]
],
[
[
1614,
21,
28762
],
[
28762,
60,
1638
]
],
[
[
1614,
24,
1264
],
[
12... | [
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trandolapril"
]
],
[
[
"Nabilone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Quinapril"
],
[
... | Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Quinapril and Quinapril (Compound) resembles Trandolapril (Compound)
Nabilone (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Trandolapril (Compound)
Nabilone may cause a moderate interaction that c... |
DB00350 | DB08815 | 1,214 | 154 | [
"DDInter1226",
"DDInter1104"
] | Minoxidil | Lurasidone | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Lurasidone is an atypical antipsychotic developed by Dainippon Sumitomo Pharma. It was approved by the U.S. Food and Drug Administration (FDA) for treatment of schizophrenia on October 29, 2010 and is currently pending approval for the treatment of bipolar disorder in the United States. | Moderate | 1 | [
[
[
1214,
24,
154
]
],
[
[
1214,
24,
401
],
[
401,
24,
154
]
],
[
[
1214,
24,
1450
],
[
1450,
63,
154
]
],
[
[
1214,
63,
475
],
[
475,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lurasidone"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Lurasidone
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Empagliflozin and E... |
DB00927 | DB01155 | 1,559 | 872 | [
"DDInter712",
"DDInter813"
] | Famotidine | Gemifloxacin | Famotidine is a competitive histamine-2 (H<sub>2</sub>) receptor antagonist that works to inhibit gastric acid secretion. It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Compared to other H<sub>2</su... | Gemifloxacin is a quinolone antibacterial agent with a broad-spectrum activity that is used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is available in oral formulations. Gemifloxacin acts by inhibiting DNA synthesis through the inhibition of both DNA gyrase... | Moderate | 1 | [
[
[
1559,
24,
872
]
],
[
[
1559,
24,
739
],
[
739,
1,
872
]
],
[
[
1559,
62,
1467
],
[
1467,
1,
872
]
],
[
[
1559,
24,
945
],
[
945,
... | [
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gemifloxacin"
]
],
[
[
"Famotidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lomefloxacin"
],
... | Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lomefloxacin (Compound) resembles Gemifloxacin (Compound)
Famotidine may cause a minor interaction that can limit clinical effects when taken with Enoxacin and Enoxacin (Compound) resembles Gemifloxacin (Compound... |
DB01229 | DB09074 | 973 | 1,362 | [
"DDInter1378",
"DDInter1327"
] | Paclitaxel (protein-bound) | Olaparib | Paclitaxel can cause developmental toxicity, female reproductive toxicity and male reproductive toxicity according to state or federal government labeling requirements. | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Moderate | 1 | [
[
[
973,
24,
1362
]
],
[
[
973,
63,
896
],
[
896,
24,
1362
]
],
[
[
973,
24,
1683
],
[
1683,
24,
1362
]
],
[
[
973,
24,
1619
],
[
1619,
... | [
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Olaparib"
]
],
[
[
"Paclitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etoposide"
],
[
... | Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Paclitaxel may cause a moderate interaction that could exacerbate diseases when taken with Etoposide and Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Olaparib
Paclitaxel may c... |
DB00427 | DB00572 | 1,233 | 85 | [
"DDInter1879",
"DDInter136"
] | Triprolidine | Atropine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosse... | Moderate | 1 | [
[
[
1233,
24,
85
]
],
[
[
1233,
63,
19
],
[
19,
24,
85
]
],
[
[
1233,
24,
551
],
[
551,
62,
85
]
],
[
[
1233,
24,
211
],
[
211,
63,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Atropine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Atropine
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Phenelzine and Ph... |
DB09481 | DB11799 | 460 | 627 | [
"DDInter1113",
"DDInter205"
] | Magnesium carbonate | Bictegravir | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Bictegravir is a recently approved investigational drug that has been used in trials studying the treatment of HIV-1 and HIV-2 infection. It has been approved for HIV-1 monotherapy combined with 2 other antiretrovirals in a single tablet. | Major | 2 | [
[
[
460,
25,
627
]
],
[
[
460,
63,
478
],
[
478,
24,
627
]
],
[
[
460,
24,
1406
],
[
1406,
63,
627
]
],
[
[
460,
62,
1468
],
[
1468,
... | [
[
[
"Magnesium carbonate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bictegravir"
]
],
[
[
"Magnesium carbonate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nilotinib"
],
[... | Magnesium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Nilotinib and Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Bictegravir
Magnesium carbonate may cause a moderate interaction that could exacerbate diseases when taken with Nera... |
DB00350 | DB01367 | 1,214 | 1,163 | [
"DDInter1226",
"DDInter1572"
] | Minoxidil | Rasagiline | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Rasagiline is an irreversible inhibitor of monoamine oxidase and is used as a monotherapy in early Parkinson's disease or as an adjunct therapy in more advanced cases. | Moderate | 1 | [
[
[
1214,
24,
1163
]
],
[
[
1214,
24,
401
],
[
401,
24,
1163
]
],
[
[
1214,
24,
849
],
[
849,
63,
1163
]
],
[
[
1214,
63,
1648
],
[
1648,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rasagiline"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Rasagiline
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepy... |
DB01097 | DB01320 | 1,377 | 651 | [
"DDInter1033",
"DDInter783"
] | Leflunomide | Fosphenytoin | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repe... | Major | 2 | [
[
[
1377,
25,
651
]
],
[
[
1377,
64,
362
],
[
362,
1,
651
]
],
[
[
1377,
6,
6017
],
[
6017,
45,
651
]
],
[
[
1377,
21,
28660
],
[
28660,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fosphenytoin"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenytoin"
],
[
"Phenytoin",
"{u}... | Leflunomide may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin (Compound) resembles Fosphenytoin (Compound)
Leflunomide (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Fosphenytoin (Compound)
Leflunomide (Compound) causes Pelvic pain (Side Effect) and Pelvic pain (Side... |
DB00327 | DB00372 | 421 | 999 | [
"DDInter890",
"DDInter1793"
] | Hydromorphone | Thiethylperazine | Hydromorphone is a pure opioid, a semi-synthetic hydrogenated ketone derivative of [morphine] that has been available clinically since 1920. Structurally, hydromorphone derived from [morphine] in the modification of the hydroxyl group in the carbon 6 to a carbonyl and the absence of a double bond between the carbon 7 a... | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Moderate | 1 | [
[
[
421,
24,
999
]
],
[
[
421,
24,
1614
],
[
1614,
63,
999
]
],
[
[
421,
63,
352
],
[
352,
24,
999
]
],
[
[
421,
24,
1242
],
[
1242,
... | [
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thiethylperazine"
]
],
[
[
"Hydromorphone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nabilone"
]... | Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Nabilone and Nabilone may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine
Hydromorphone may cause a moderate interaction that could exacerbate diseases when taken with Trospium and ... |
DB00802 | DB01128 | 1,322 | 918 | [
"DDInter43",
"DDInter204"
] | Alfentanil | Bicalutamide | A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Moderate | 1 | [
[
[
1322,
24,
918
]
],
[
[
1322,
24,
129
],
[
129,
40,
918
]
],
[
[
1322,
6,
8374
],
[
8374,
45,
918
]
],
[
[
1322,
21,
29232
],
[
29232,
... | [
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bicalutamide"
]
],
[
[
"Alfentanil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
],
... | Alfentanil may cause a moderate interaction that could exacerbate diseases when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Alfentanil (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Alfentanil (Compound) causes Urticaria (Side Effect) and U... |
DB01042 | DB11601 | 1,307 | 1,270 | [
"DDInter1144",
"DDInter1889"
] | Melphalan | Tuberculin purified protein derivative | Melphalan is a nitrogen mustard or bischloroethylamine type alkylating agent. It was first synthesized in the early 1950s by substituting L-phenylalanine for the methyl group on nitrogen mustard.[A261150, A261155] Melphalan is used in the treatment of multiple myeloma and ovarian carcinoma. It is also used for high-con... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
1307,
24,
1270
]
],
[
[
1307,
24,
1531
],
[
1531,
24,
1270
]
],
[
[
1307,
63,
869
],
[
869,
24,
1270
]
],
[
[
1307,
64,
1064
],
[
1064... | [
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Melphalan",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"C... | Melphalan may cause a moderate interaction that could exacerbate diseases when taken with Canakinumab and Canakinumab may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Melphalan may cause a moderate interaction that could exacerbate diseases when take... |
DB00570 | DB12147 | 147 | 241 | [
"DDInter1936",
"DDInter661"
] | Vinblastine | Erdafitinib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | In early April of 2019, the US FDA approved Janssen Pharmaceutical Companies' brand name Balversa (erdafitinib) as the first-ever fibroblast growth factor receptor (FGFR) kinase inhibitor indicated for patients with locally advanced or metastatic urothelial carcinoma, with susceptible FGFR3 or FGFR2 genetic alterations... | Moderate | 1 | [
[
[
147,
24,
241
]
],
[
[
147,
25,
384
],
[
384,
24,
241
]
],
[
[
147,
24,
982
],
[
982,
63,
241
]
],
[
[
147,
24,
467
],
[
467,
24,... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Erdafitinib"
]
],
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Idelalisib"
],
[
"Idelali... | Vinblastine may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Erdafitinib
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Ivosidenib and Ivosidenib may cau... |
DB00603 | DB01045 | 303 | 463 | [
"DDInter1137",
"DDInter1590"
] | Medroxyprogesterone acetate | Rifampicin | Medroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. MPA can be use to treat secondary amenorrhea, endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prev... | A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation ... | Moderate | 1 | [
[
[
303,
24,
463
]
],
[
[
303,
24,
690
],
[
690,
40,
463
]
],
[
[
303,
6,
6017
],
[
6017,
45,
463
]
],
[
[
303,
64,
1101
],
[
1101,
... | [
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rifampicin"
]
],
[
[
"Medroxyprogesterone acetate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
... | Medroxyprogesterone acetate may cause a moderate interaction that could exacerbate diseases when taken with Rifabutin and Rifabutin (Compound) resembles Rifampicin (Compound)
Medroxyprogesterone acetate (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Rifampicin (Compound)
Medroxyprogesterone acetate may le... |
DB00673 | DB01211 | 723 | 609 | [
"DDInter112",
"DDInter393"
] | Aprepitant | Clarithromycin | Aprepitant, an antiemetic, is a substance P/neurokinin 1 (NK1) receptor antagonist which, in combination with other antiemetic agents, is indicated for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy. Aprepitant is a selective h... | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Moderate | 1 | [
[
[
723,
24,
609
]
],
[
[
723,
6,
7524
],
[
7524,
45,
609
]
],
[
[
723,
54,
19146
],
[
19146,
15,
609
]
],
[
[
723,
21,
28759
],
[
28759,
... | [
[
[
"Aprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clarithromycin"
]
],
[
[
"Aprepitant",
"{u} (Compound) binds {v} (Gene)",
"CYP3A5"
],
[
"CYP3A5",
"{u} (Gene) is bound by {v} (Compoun... | Aprepitant (Compound) binds CYP3A5 (Gene) and CYP3A5 (Gene) is bound by Clarithromycin (Compound)
Aprepitant (Compound) is included by Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) and Cytochrome P450 3A4 Inhibitors (Pharmacologic Class) includes Clarithromycin (Compound)
Aprepitant (Compound) causes Connective ... |
DB00222 | DB00687 | 245 | 870 | [
"DDInter825",
"DDInter747"
] | Glimepiride | Fludrocortisone | First introduced in 1995, glimepiride is a member of the second-generation sulfonylurea (SU) drug class used for the management of type 2 diabetes mellitus (T2DM) to improve glycemic control. Type 2 diabetes is a metabolic disorder with increasing prevalences worldwide; it is characterized by insulin resistance in acco... | Fludrocortisone is a synthetic mineralocorticoid used in conjunction with [hydrocortisone] to replace missing endogenous corticosteroids in patients with adrenal insufficiency.[A187169,A187187] It is functionally similar to [aldosterone], the body's primary endogenous mineralocorticoid, and is structurally analogous to... | Moderate | 1 | [
[
[
245,
24,
870
]
],
[
[
245,
24,
1220
],
[
1220,
40,
870
]
],
[
[
245,
24,
1561
],
[
1561,
24,
870
]
],
[
[
245,
23,
1103
],
[
1103,
... | [
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludrocortisone"
]
],
[
[
"Glimepiride",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dexamethasone"
]... | Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Dexamethasone and Dexamethasone (Compound) resembles Fludrocortisone (Compound)
Glimepiride may cause a moderate interaction that could exacerbate diseases when taken with Testosterone and Testosterone may cause a moderate inter... |
DB01359 | DB11363 | 729 | 1,276 | [
"DDInter1417",
"DDInter39"
] | Penbutolol | Alectinib | Penbutolol is a drug in the beta-blocker class used to treat hypertension. Penbutolol binds both beta-1 and beta-2 adrenergic receptors, rendering it a non-selective beta-blocker. Penbutolol can act as a partial agonist at beta adrenergic receptors, since it is a sympathomimetric drug. Penbutolol also demonstrates high... | Alectinib is a second generation oral drug that selectively inhibits the activity of anaplastic lymphoma kinase (ALK) tyrosine kinase. It is specifically used in the treatment of non-small cell lung cancer (NSCLC) expressing the ALK-EML4 (echinoderm microtubule-associated protein-like 4) fusion protein that causes prol... | Moderate | 1 | [
[
[
729,
24,
1276
]
],
[
[
729,
25,
1011
],
[
1011,
24,
1276
]
],
[
[
729,
1,
699
],
[
699,
24,
1276
]
],
[
[
729,
63,
1528
],
[
1528,
... | [
[
[
"Penbutolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alectinib"
]
],
[
[
"Penbutolol",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fingolimod"
],
[
"Fingolimod"... | Penbutolol may lead to a major life threatening interaction when taken with Fingolimod and Fingolimod may cause a moderate interaction that could exacerbate diseases when taken with Alectinib
Penbutolol (Compound) resembles Nadolol (Compound) and Nadolol may cause a moderate interaction that could exacerbate diseases w... |
DB00619 | DB09381 | 1,419 | 192 | [
"DDInter909",
"DDInter678"
] | Imatinib | Esterified estrogens | Imatinib is a small molecule kinase inhibitor that revolutionized the treatment of cancer, particularly chronic myeloid leukemia, in 2001. It was deemed a "miracle drug" due to its clinical success, as oncologist Dr. Brian noted that "complete hematologic responses were observed in 53 of 54 patients with CML treated wi... | Esterified estrogens contain a mixture of estrogenic substances; the principle component is estrone. Preparations contain 75% to 85% sodium estrone sulfate and 6% to 15% sodium equilin sulfate such that the total is not <90%. Esterified estrogens are a man-made mixture of estrogens that are used to treat symptoms of me... | Moderate | 1 | [
[
[
1419,
24,
192
]
],
[
[
1419,
63,
752
],
[
752,
23,
192
]
],
[
[
1419,
24,
1264
],
[
1264,
23,
192
]
],
[
[
1419,
25,
1019
],
[
1019,
... | [
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Esterified estrogens"
]
],
[
[
"Imatinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cimetidine"
],
... | Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Cimetidine and Cimetidine may cause a minor interaction that can limit clinical effects when taken with Esterified estrogens
Imatinib may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Doxep... |
DB06589 | DB09122 | 1,250 | 1,613 | [
"DDInter1400",
"DDInter1409"
] | Pazopanib | Peginterferon beta-1a | Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009. | Multiple Sclerosis (MS) is a chronic and inflammatory autoimmune disease of the central nervous system, disrupting communication between the brain and other parts of the body. Most patients diagnosed with this illness experience their initial disease symptoms between the age of 20 to 40, often the most productive years... | Moderate | 1 | [
[
[
1250,
24,
1613
]
],
[
[
1250,
63,
671
],
[
671,
24,
1613
]
],
[
[
1250,
24,
1627
],
[
1627,
24,
1613
]
],
[
[
1250,
24,
975
],
[
975,
... | [
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Peginterferon beta-1a"
]
],
[
[
"Pazopanib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fluvastatin"
]... | Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Fluvastatin and Fluvastatin may cause a moderate interaction that could exacerbate diseases when taken with Peginterferon beta-1a
Pazopanib may cause a moderate interaction that could exacerbate diseases when taken with Cannabidio... |
DB00682 | DB01150 | 126 | 315 | [
"DDInter1951",
"DDInter327"
] | Warfarin | Cefprozil | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Cefprozil is a cephalosporin antibiotic that is commonly employed to treat a variety of bacterial infections, including those of the ear and skin, bronchitis, and others. | Moderate | 1 | [
[
[
126,
24,
315
]
],
[
[
126,
24,
1024
],
[
1024,
40,
315
]
],
[
[
126,
24,
207
],
[
207,
1,
315
]
],
[
[
126,
63,
778
],
[
778,
1,... | [
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefprozil"
]
],
[
[
"Warfarin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefpodoxime"
],
[
... | Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cefpodoxime and Cefpodoxime (Compound) resembles Cefprozil (Compound)
Warfarin may cause a moderate interaction that could exacerbate diseases when taken with Cefradine and Cefradine (Compound) resembles Cefprozil (Compound)
Warfar... |
DB00182 | DB09481 | 80 | 460 | [
"DDInter84",
"DDInter1113"
] | Amphetamine | Magnesium carbonate | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Magnesium carbonate, also known as magnesite, is a common over the counter remedy for heartburn and upset stomach caused by overproduction of acid in the stomach [FDA Label]. | Moderate | 1 | [
[
[
80,
24,
460
]
],
[
[
80,
24,
401
],
[
401,
23,
460
]
],
[
[
80,
40,
633
],
[
633,
24,
460
]
],
[
[
80,
24,
542
],
[
542,
24,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Magnesium carbonate"
]
],
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
... | Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a minor interaction that can limit clinical effects when taken with Magnesium carbonate
Amphetamine (Compound) resembles Lisdexamfetamine (Compound) and Lisdexamfetamine may cause a modera... |
DB00980 | DB09330 | 969 | 985 | [
"DDInter1564",
"DDInter1352"
] | Ramelteon | Osimertinib | Ramelteon is the first in a new class of sleep agents that selectively binds to the melatonin receptors in the suprachiasmatic nucleus (SCN). It is used for insomnia, particularly delayed sleep onset. Ramelteon has not been shown to produce dependence and has shown no potential for abuse. | Osimertinib is an oral, third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) drug developed by AstraZeneca Pharmaceuticals.[A7926,L43453] Its use is indicated for the treatment of metastatic non-small cell lung cancer (NSCLC) in cases where tumour EGFR expression is positive for the ... | Moderate | 1 | [
[
[
969,
24,
985
]
],
[
[
969,
63,
1684
],
[
1684,
24,
985
]
],
[
[
969,
24,
1040
],
[
1040,
24,
985
]
],
[
[
969,
24,
1033
],
[
1033,
... | [
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osimertinib"
]
],
[
[
"Ramelteon",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Caffeine"
],
[
... | Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Caffeine and Caffeine may cause a moderate interaction that could exacerbate diseases when taken with Osimertinib
Ramelteon may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib ... |
DB00694 | DB10343 | 51 | 962 | [
"DDInter485",
"DDInter160"
] | Daunorubicin | Bacillus calmette-guerin substrain tice live antigen | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | Bacillus calmette-guerin substrain tice live antigen is a vaccine containing attenuated live culture preparation of the Bacillus of Calmette and Guerin (BCG) strain of *Mycobacterium bovis* for percutaneous use. It is administered to prevent the development of tuberculosis. | Major | 2 | [
[
[
51,
25,
962
]
],
[
[
51,
64,
1057
],
[
1057,
25,
962
]
],
[
[
51,
24,
1342
],
[
1342,
25,
962
]
],
[
[
51,
24,
270
],
[
270,
64,... | [
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bacillus calmette-guerin substrain tice live antigen"
]
],
[
[
"Daunorubicin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Etanercept"... | Daunorubicin may lead to a major life threatening interaction when taken with Etanercept and Etanercept may lead to a major life threatening interaction when taken with Bacillus calmette-guerin substrain tice live antigen
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Romid... |
DB01222 | DB09035 | 617 | 410 | [
"DDInter246",
"DDInter1308"
] | Budesonide | Nivolumab | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Nivolumab is a fully human IgG4 antibody targeting the immune checkpoint programmed death receptor-1 (PD-1). This antibody was produced entirely in mice and grafted onto human kappa and IgG4 Fc region with the mutation _S228P_ for additional stability and reduced variability. It was developed by Bristol Myers Squibb. N... | Moderate | 1 | [
[
[
617,
24,
410
]
],
[
[
617,
40,
1573
],
[
1573,
24,
410
]
],
[
[
617,
25,
384
],
[
384,
63,
410
]
],
[
[
617,
40,
1573
],
[
1573,
... | [
[
[
"Budesonide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nivolumab"
]
],
[
[
"Budesonide",
"{u} (Compound) resembles {v} (Compound)",
"Prednisone"
],
[
"Prednisone",
"{u} may cause a moderate... | Budesonide (Compound) resembles Prednisone (Compound) and Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Nivolumab
Budesonide may lead to a major life threatening interaction when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate dise... |
DB00912 | DB01149 | 473 | 851 | [
"DDInter1581",
"DDInter1274"
] | Repaglinide | Nefazodone | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or ev... | Moderate | 1 | [
[
[
473,
24,
851
]
],
[
[
473,
63,
1178
],
[
1178,
1,
851
]
],
[
[
473,
24,
673
],
[
673,
40,
851
]
],
[
[
473,
6,
8374
],
[
8374,
4... | [
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
]
],
[
[
"Repaglinide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
],
... | Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Nefazodone (Compound)
Repaglinide may cause a moderate interaction that could exacerbate diseases when taken with Aripiprazole and Aripiprazole (Compound) resembles Nefazo... |
DB01006 | DB11730 | 300 | 351 | [
"DDInter1040",
"DDInter1588"
] | Letrozole | Ribociclib | Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. Letrozole... | Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced p... | Moderate | 1 | [
[
[
300,
24,
351
]
],
[
[
300,
24,
283
],
[
283,
62,
351
]
],
[
[
300,
23,
1627
],
[
1627,
23,
351
]
],
[
[
300,
24,
1654
],
[
1654,
... | [
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
]
],
[
[
"Letrozole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
],
[
... | Letrozole may cause a moderate interaction that could exacerbate diseases when taken with Fedratinib and Fedratinib may cause a minor interaction that can limit clinical effects when taken with Ribociclib
Letrozole may cause a minor interaction that can limit clinical effects when taken with Cannabidiol and Cannabidiol... |
DB00637 | DB09272 | 1,557 | 412 | [
"DDInter128",
"DDInter632"
] | Astemizole | Eluxadoline | Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice. | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
1557,
24,
412
]
],
[
[
1557,
25,
441
],
[
441,
24,
412
]
],
[
[
1557,
24,
543
],
[
543,
24,
412
]
],
[
[
1557,
63,
252
],
[
252,
... | [
[
[
"Astemizole",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Astemizole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Delavirdine"
],
[
"Delavird... | Astemizole may lead to a major life threatening interaction when taken with Delavirdine and Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Astemizole may cause a moderate interaction that could exacerbate diseases when taken with Loperamide and Loperamide may cau... |
DB00570 | DB06414 | 147 | 655 | [
"DDInter1936",
"DDInter703"
] | Vinblastine | Etravirine | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
147,
24,
655
]
],
[
[
147,
6,
4973
],
[
4973,
45,
655
]
],
[
[
147,
21,
28722
],
[
28722,
60,
655
]
],
[
[
147,
63,
1101
],
[
1101,
... | [
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Vinblastine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",... | Vinblastine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Etravirine (Compound)
Vinblastine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Etravirine (Compound)
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexaroten... |
DB01138 | DB12141 | 804 | 971 | [
"DDInter1726",
"DDInter817"
] | Sulfinpyrazone | Gilteritinib | A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties. | Gilteritinib, also known as ASP2215, is a small molecule part of the FLT3 tyrosine kinase inhibitors that presented a greater selectivity and potency when compared with other agents from this group. It is a pyrazinecarboxamide derivative that showed high selectivity to FLT3 preventing the c-Kit -driven myelosuppression... | Moderate | 1 | [
[
[
804,
24,
971
]
],
[
[
804,
24,
1135
],
[
1135,
23,
971
]
],
[
[
804,
24,
466
],
[
466,
62,
971
]
],
[
[
804,
25,
1409
],
[
1409,
... | [
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gilteritinib"
]
],
[
[
"Sulfinpyrazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Naloxegol"
],... | Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Naloxegol and Naloxegol may cause a minor interaction that can limit clinical effects when taken with Gilteritinib
Sulfinpyrazone may cause a moderate interaction that could exacerbate diseases when taken with Darolutamide an... |
DB06717 | DB09098 | 875 | 98 | [
"DDInter778",
"DDInter1700"
] | Fosaprepitant | Somatrem | Fosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant. It aids in the prevention of acute and delayed nausea and vomiting associated with chemotherapy treatment. | Despite the ability of almost all contemporary recombinant growth hormones to cause definite and demonstrable increases in growth rate in patients who are administered the drug, the use of these agents continues to be mired in persistent bioethical debate . Such discussion revolves around whether patients' natural disp... | Moderate | 1 | [
[
[
875,
24,
98
]
],
[
[
875,
63,
608
],
[
608,
23,
98
]
],
[
[
875,
24,
159
],
[
159,
63,
98
]
],
[
[
875,
63,
11
],
[
11,
24,
... | [
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Somatrem"
]
],
[
[
"Fosaprepitant",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lidocaine"
],
[... | Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Lidocaine and Lidocaine may cause a minor interaction that can limit clinical effects when taken with Somatrem
Fosaprepitant may cause a moderate interaction that could exacerbate diseases when taken with Larotrectinib and Lar... |
DB00059 | DB01118 | 1,560 | 33 | [
"DDInter1404",
"DDInter76"
] | Pegaspargase | Amiodarone | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Moderate | 1 | [
[
[
1560,
24,
33
]
],
[
[
1560,
24,
540
],
[
540,
1,
33
]
],
[
[
1560,
24,
168
],
[
168,
24,
33
]
],
[
[
1560,
24,
1496
],
[
1496,
6... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amiodarone"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dronedarone"
],
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Dronedarone and Dronedarone (Compound) resembles Amiodarone (Compound)
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a moderate interaction that... |
DB00902 | DB14881 | 104 | 180 | [
"DDInter1168",
"DDInter1329"
] | Methdilazine | Oliceridine | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
104,
24,
180
]
],
[
[
104,
24,
401
],
[
401,
24,
180
]
],
[
[
104,
63,
85
],
[
85,
24,
180
]
],
[
[
104,
1,
830
],
[
830,
24,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Oliceridine
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and... |
DB09263 | DB11093 | 1,436 | 636 | [
"DDInter1399",
"DDInter273"
] | Patiromer | Calcium citrate | Patiromer is a powder for suspension in water for oral administration, approved in the U.S. as Veltassa in October, 2015. Patiromer is supplied as patiromer sorbitex calcium which consists of the active moiety, patiromer, a non-absorbed potassium-binding polymer, and a calcium-sorbitol counterion. Each gram of patirome... | Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements. | Moderate | 1 | [
[
[
1436,
24,
636
]
],
[
[
1436,
63,
542
],
[
542,
24,
636
]
],
[
[
1436,
64,
115
],
[
115,
25,
636
]
],
[
[
1436,
63,
542
],
[
542,
... | [
[
[
"Patiromer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Calcium citrate"
]
],
[
[
"Patiromer",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Levothyroxine"
],
... | Patiromer may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine may cause a moderate interaction that could exacerbate diseases when taken with Calcium citrate
Patiromer may lead to a major life threatening interaction when taken with Aluminum hydroxide and Alum... |
DB00197 | DB00624 | 1,324 | 1,561 | [
"DDInter1881",
"DDInter1775"
] | Troglitazone | Testosterone | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual charact... | Moderate | 1 | [
[
[
1324,
24,
1561
]
],
[
[
1324,
24,
1438
],
[
1438,
1,
1561
]
],
[
[
1324,
24,
870
],
[
870,
63,
1561
]
],
[
[
1324,
24,
482
],
[
482,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Testosterone"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Estradiol"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Estradiol and Estradiol (Compound) resembles Testosterone (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Fludrocortisone and Fludrocortisone may cause a moderate interact... |
DB00023 | DB00857 | 305 | 1,387 | [
"DDInter127",
"DDInter1768"
] | Asparaginase Escherichia coli | Terbinafine | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Terbinafine hydrochloride (Lamisil) is a synthetic allylamine antifungal.[L9065,L9068] It is highly lipophilic in nature and tends to accumulate in skin, nails, and fatty tissues. Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting the fungal squalene monooxygenase (also called squalene epox... | Moderate | 1 | [
[
[
305,
24,
1387
]
],
[
[
305,
24,
168
],
[
168,
23,
1387
]
],
[
[
305,
24,
463
],
[
463,
62,
1387
]
],
[
[
305,
24,
109
],
[
109,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Terbinafine"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Terbinafine
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases ... |
DB00065 | DB15035 | 581 | 503 | [
"DDInter923",
"DDInter1959"
] | Infliximab | Zanubrutinib | Infliximab is a tumor necrosis factor (TNF-alpha or TNF-α) blocker and a chimeric monoclonal IgG1 antibody composed of human constant (75%) and murine variable (25%) regions. Infliximab is produced by a recombinant cell line cultured by continuous perfusion. Tumor necrosis factor-alpha (TNF-α) is a key proinflammatory ... | Zanubrutinib is a novel Bruton's tyrosine kinase (BTK) inhibitor used for the treatment of adult patients with mantle cell lymphoma (MCL) who have received at least one prior therapy. Mantle cell lymphoma is an aggressive mature B-cell non-Hodgkin lymphoma associated with early relapse, poor clinical outcomes, and long... | Major | 2 | [
[
[
581,
25,
503
]
],
[
[
581,
24,
1430
],
[
1430,
24,
503
]
],
[
[
581,
25,
1683
],
[
1683,
24,
503
]
],
[
[
581,
64,
1184
],
[
1184,
... | [
[
[
"Infliximab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Zanubrutinib"
]
],
[
[
"Infliximab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
],
[
"Sipule... | Infliximab may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T and Sipuleucel-T may cause a moderate interaction that could exacerbate diseases when taken with Zanubrutinib
Infliximab may lead to a major life threatening interaction when taken with Ustekinumab and Ustekinumab ma... |
DB00261 | DB04951 | 702 | 187 | [
"DDInter93",
"DDInter1477"
] | Anagrelide | Pirfenidone | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Pirfenidone is a synthetic pyridone drug. It is an antifibrotic agent with anti-inflammatory and antioxidant properties that is used to treat idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive form of interstitial pneumonia. While its mechanism of action is not yet fully understood, pirfenidone is pro... | Moderate | 1 | [
[
[
702,
24,
187
]
],
[
[
702,
63,
168
],
[
168,
23,
187
]
],
[
[
702,
24,
463
],
[
463,
24,
187
]
],
[
[
702,
25,
996
],
[
996,
63,... | [
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pirfenidone"
]
],
[
[
"Anagrelide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bortezomib"
],
[
... | Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may cause a minor interaction that can limit clinical effects when taken with Pirfenidone
Anagrelide may cause a moderate interaction that could exacerbate diseases when taken with Rifampicin and Rifampi... |
DB00209 | DB00850 | 352 | 1,630 | [
"DDInter1886",
"DDInter1432"
] | Trospium | Perphenazine | Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably. An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination. Trospium is manufactured by _Indevu... | An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. | Moderate | 1 | [
[
[
352,
24,
1630
]
],
[
[
352,
24,
252
],
[
252,
40,
1630
]
],
[
[
352,
6,
12523
],
[
12523,
45,
1630
]
],
[
[
352,
21,
29232
],
[
29232,... | [
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
]
],
[
[
"Trospium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroxyzine"
],
[
... | Trospium may cause a moderate interaction that could exacerbate diseases when taken with Hydroxyzine and Hydroxyzine (Compound) resembles Perphenazine (Compound)
Trospium (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Perphenazine (Compound)
Trospium (Compound) causes Urticaria (Side Effect) and Urticaria... |
DB00372 | DB09272 | 999 | 412 | [
"DDInter1793",
"DDInter632"
] | Thiethylperazine | Eluxadoline | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | Eluxadoline is a mixed mu-opioid receptor agonist, kappa-opioid receptor agonist, and a-delta opioid receptor antagonist indicated for use in diarrhea-predominant irritable bowel syndrome (IBS-D). The mu-, kappa-, and delta-opioid receptors mediate endogenous and exogenous opioid response in the central nervous system ... | Moderate | 1 | [
[
[
999,
24,
412
]
],
[
[
999,
63,
1594
],
[
1594,
24,
412
]
],
[
[
999,
24,
1105
],
[
1105,
24,
412
]
],
[
[
999,
24,
1536
],
[
1536,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eluxadoline"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Doxylamine"
... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may cause a moderate interaction that could exacerbate diseases when taken with Eluxadoline
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Trihexyp... |
DB01211 | DB04855 | 609 | 540 | [
"DDInter393",
"DDInter602"
] | Clarithromycin | Dronedarone | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Dronedarone is a Class III antiarrhythmic drug that works to restore the normal sinus rhythm in patients with paroxysmal or persistent atrial fibrillation. Atrial fibrillation is a common sustained arrhythmia where the treatment primarily focuses on stroke prevention and symptom management. It is managed by rate contro... | Major | 2 | [
[
[
609,
25,
540
]
],
[
[
609,
64,
347
],
[
347,
40,
540
]
],
[
[
609,
6,
8374
],
[
8374,
45,
540
]
],
[
[
609,
21,
28883
],
[
28883,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dronedarone"
]
],
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibutilide"
],
[
"Ibutilide",
... | Clarithromycin may lead to a major life threatening interaction when taken with Ibutilide and Ibutilide (Compound) resembles Dronedarone (Compound)
Clarithromycin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dronedarone (Compound)
Clarithromycin (Compound) causes Skin disorder (Side Effect) and Skin dis... |
DB06697 | DB11560 | 436 | 1,678 | [
"DDInter121",
"DDInter1038"
] | Artemether | Lesinurad | Artemether is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with lumefantrine for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of <i>Plasmodium spp.</i> and may be used to treat infections caused by <i>P. falciparum</... | Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter assoc... | Moderate | 1 | [
[
[
436,
24,
1678
]
],
[
[
436,
25,
913
],
[
913,
63,
1678
]
],
[
[
436,
24,
1040
],
[
1040,
24,
1678
]
],
[
[
436,
24,
1017
],
[
1017,
... | [
[
[
"Artemether",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lesinurad"
]
],
[
[
"Artemether",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apalutamide"
],
[
"Apalutamid... | Artemether may lead to a major life threatening interaction when taken with Apalutamide and Apalutamide may cause a moderate interaction that could exacerbate diseases when taken with Lesinurad
Artemether may cause a moderate interaction that could exacerbate diseases when taken with Dabrafenib and Dabrafenib may cause... |
DB01181 | DB08899 | 1,532 | 129 | [
"DDInter906",
"DDInter649"
] | Ifosfamide | Enzalutamide | Ifosfamide is a chemotherapeutic agent chemically related to the nitrogen mustards and a synthetic analog of cyclophosphamide. It is active as an alkylating agent and an immunosuppressive agent. | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Moderate | 1 | [
[
[
1532,
24,
129
]
],
[
[
1532,
6,
8374
],
[
8374,
45,
129
]
],
[
[
1532,
21,
28703
],
[
28703,
60,
129
]
],
[
[
1532,
25,
1510
],
[
1510... | [
[
[
"Ifosfamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enzalutamide"
]
],
[
[
"Ifosfamide",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)... | Ifosfamide (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Enzalutamide (Compound)
Ifosfamide (Compound) causes Pruritus (Side Effect) and Pruritus (Side Effect) is caused by Enzalutamide (Compound)
Ifosfamide may lead to a major life threatening interaction when taken with Teriflunomide and Teriflunomide ... |
DB00924 | DB11130 | 1,405 | 407 | [
"DDInter454",
"DDInter1344"
] | Cyclobenzaprine | Opium | Cyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961 and has been available for human use since 1977. It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.[A185039,A184... | Opium is the first substance of the diverse group of the opiates. It has been known for a long time, and the first evidence of a poppy culture dates from 5 thousand years by the Sumerians. During the years, opium was used as a sedative and hypnotic, but it was determined to be addictive. Opium is extracted from _Papave... | Moderate | 1 | [
[
[
1405,
24,
407
]
],
[
[
1405,
63,
662
],
[
662,
24,
407
]
],
[
[
1405,
24,
849
],
[
849,
24,
407
]
],
[
[
1405,
25,
1264
],
[
1264,
... | [
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
]
],
[
[
"Cyclobenzaprine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbinoxamine"
],
... | Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Carbinoxamine and Carbinoxamine may cause a moderate interaction that could exacerbate diseases when taken with Opium
Cyclobenzaprine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine... |
DB00350 | DB06237 | 1,214 | 438 | [
"DDInter1226",
"DDInter141"
] | Minoxidil | Avanafil | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | Avanafil is a phosphodiesterase-5 (PDE5) inhibitor used in the treatment of erectile dysfunction. In comparison with other drugs of the same class, it shows greater selectivity for PDE5 over PDE6 than both [sildenafil] and [vardenafil] but less selectivity than [tadalafil], suggesting a relatively lower risk of visual ... | Moderate | 1 | [
[
[
1214,
24,
438
]
],
[
[
1214,
24,
549
],
[
549,
63,
438
]
],
[
[
1214,
24,
885
],
[
885,
24,
438
]
],
[
[
1214,
24,
549
],
[
549,
... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Avanafil"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
],
[
... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Dapagliflozin and Dapagliflozin may cause a moderate interaction that could exacerbate diseases when taken with Avanafil
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Epoprostenol and Ep... |
DB09074 | DB12500 | 1,362 | 283 | [
"DDInter1327",
"DDInter714"
] | Olaparib | Fedratinib | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1362,
24,
283
]
],
[
[
1362,
25,
351
],
[
351,
23,
283
]
],
[
[
1362,
64,
1593
],
[
1593,
23,
283
]
],
[
[
1362,
25,
1339
],
[
1339,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ribociclib"
],
[
"Ribociclib",
... | Olaparib may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Olaparib may lead to a major life threatening interaction when taken with Crizotinib and Crizotinib may cause a minor interaction t... |
DB00470 | DB01069 | 530 | 401 | [
"DDInter601",
"DDInter1533"
] | Dronabinol | Promethazine | Dronabinol (marketed as Marinol) is a synthetic form of delta-9-tetrahydrocannabinol (Δ⁹-THC), the primary psychoactive component of cannabis (marijuana). THC demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors, which results in the well-known effect... | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Moderate | 1 | [
[
[
530,
24,
401
]
],
[
[
530,
24,
146
],
[
146,
24,
401
]
],
[
[
530,
24,
1264
],
[
1264,
63,
401
]
],
[
[
530,
6,
6017
],
[
6017,
... | [
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
]
],
[
[
"Dronabinol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propiomazine"
],
... | Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Propiomazine and Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine
Dronabinol may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Dox... |
DB04865 | DB08875 | 4 | 1,618 | [
"DDInter1335",
"DDInter262"
] | Omacetaxine mepesuccinate | Cabozantinib | Omacetaxine mepesuccinate (formerly known as HHT or Homoharringtonine), is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Omacetaxine mepesuccinate is synthesized from cephalotaxine, which is an extract from the leaves of the pla... | Cabozantinib was first approved in 2012 and is a non-specific tyrosine kinase inhibitor. It was initially approved in the US under the brand name Cometriq, which is indicated for the treatment of metastatic medullary thyroid cancer. In 2016, a capsule formulation (Cabometyx) was approved for the treatment of advanced r... | Major | 2 | [
[
[
4,
25,
1618
]
],
[
[
4,
24,
384
],
[
384,
63,
1618
]
],
[
[
4,
63,
1668
],
[
1668,
24,
1618
]
],
[
[
4,
24,
850
],
[
850,
24,
... | [
[
[
"Omacetaxine mepesuccinate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cabozantinib"
]
],
[
[
"Omacetaxine mepesuccinate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib... | Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and Idelalisib may cause a moderate interaction that could exacerbate diseases when taken with Cabozantinib
Omacetaxine mepesuccinate may cause a moderate interaction that could exacerbate diseases when ... |
DB00691 | DB06691 | 1,058 | 849 | [
"DDInter1237",
"DDInter1155"
] | Moexipril | Mepyramine | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect. It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescrip... | Moderate | 1 | [
[
[
1058,
24,
849
]
],
[
[
1058,
63,
1648
],
[
1648,
24,
849
]
],
[
[
1058,
24,
407
],
[
407,
63,
849
]
],
[
[
1058,
24,
1376
],
[
1376,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aldesleukin"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Aldesleukin and Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine
Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may c... |
DB00880 | DB01017 | 359 | 1,669 | [
"DDInter360",
"DDInter1224"
] | Chlorothiazide | Minocycline | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812) | Minocycline was first described in the literacture in 1966. It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria. Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetr... | Minor | 0 | [
[
[
359,
23,
1669
]
],
[
[
359,
62,
1572
],
[
1572,
1,
1669
]
],
[
[
359,
62,
1545
],
[
1545,
40,
1669
]
],
[
[
359,
6,
10612
],
[
10612,
... | [
[
[
"Chlorothiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Minocycline"
]
],
[
[
"Chlorothiazide",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Demeclocycline"
],... | Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Demeclocycline and Demeclocycline (Compound) resembles Minocycline (Compound)
Chlorothiazide may cause a minor interaction that can limit clinical effects when taken with Oxytetracycline and Oxytetracycline (Compound) resembles... |
DB00252 | DB00341 | 362 | 1,242 | [
"DDInter1460",
"DDInter343"
] | Phenytoin | Cetirizine | Phenytoin is classified as a hydantoin derivative and despite its narrow therapeutic index, it is one of the most commonly used anticonvulsants.[A33595,A188832,A189219] Since it's introduction about 80 years ago, phenytoin has not only been established as an effective anti-epileptic, but has also been investigated for ... | Cetirizine, also commonly known as _Zyrtec_, is an orally active second-generation histamine H1 antagonist proven effective in the treatment of various allergic symptoms, such as sneezing, coughing, nasal congestion, hives, and other symptoms , . One of the most common uses for this drug is for a condition called _alle... | Moderate | 1 | [
[
[
362,
24,
1242
]
],
[
[
362,
24,
537
],
[
537,
63,
1242
]
],
[
[
362,
21,
29323
],
[
29323,
60,
1242
]
],
[
[
362,
24,
1031
],
[
1031,
... | [
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cetirizine"
]
],
[
[
"Phenytoin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
[
... | Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine may cause a moderate interaction that could exacerbate diseases when taken with Cetirizine
Phenytoin (Compound) causes Paralysis (Side Effect) and Paralysis (Side Effect) is caused by Cetirizine (Compound)
... |
DB00744 | DB12500 | 1,288 | 283 | [
"DDInter1962",
"DDInter714"
] | Zileuton | Fedratinib | Leukotrienes are substances that induce numerous biological effects including augmentation of neutrophil and eosinophil migration, neutrophil and monocyte aggregation, leukocyte adhesion, increased capillary permeability, and smooth muscle contraction. These effects contribute to inflammation, edema, mucus secretion, a... | Fedratinib, also known as SAR302503 and TG101348, is a tyrosine kinase inhibitor used to treat intermediate-2 and high risk primary and secondary myelofibrosis.[A183176,L8090] It is an anilinopyrimidine derivative. Fedratinib was granted FDA approval on August 16, 2019. | Moderate | 1 | [
[
[
1288,
24,
283
]
],
[
[
1288,
24,
351
],
[
351,
23,
283
]
],
[
[
1288,
63,
1419
],
[
1419,
24,
283
]
],
[
[
1288,
24,
985
],
[
985,
... | [
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fedratinib"
]
],
[
[
"Zileuton",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ribociclib"
],
[
... | Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib and Ribociclib may cause a minor interaction that can limit clinical effects when taken with Fedratinib
Zileuton may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may c... |
DB08827 | DB08870 | 990 | 850 | [
"DDInter1085",
"DDInter228"
] | Lomitapide | Brentuximab vedotin | Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid (R). | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Major | 2 | [
[
[
990,
25,
850
]
],
[
[
990,
64,
611
],
[
611,
24,
850
]
],
[
[
990,
25,
1583
],
[
1583,
63,
850
]
],
[
[
990,
63,
134
],
[
134,
2... | [
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Brentuximab vedotin"
]
],
[
[
"Lomitapide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dacarbazine"
],
[
"Dacarbazine",
... | Lomitapide may lead to a major life threatening interaction when taken with Dacarbazine and Dacarbazine may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin
Lomitapide may lead to a major life threatening interaction when taken with Sarilumab and Sarilumab may cause a mode... |
DB00861 | DB01254 | 914 | 1,213 | [
"DDInter551",
"DDInter484"
] | Diflunisal | Dasatinib | Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear ... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Major | 2 | [
[
[
914,
25,
1213
]
],
[
[
914,
7,
7483
],
[
7483,
46,
1213
]
],
[
[
914,
18,
1918
],
[
1918,
57,
1213
]
],
[
[
914,
21,
28882
],
[
28882,... | [
[
[
"Diflunisal",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dasatinib"
]
],
[
[
"Diflunisal",
"{u} (Compound) upregulates {v} (Gene)",
"HLA-DMA"
],
[
"HLA-DMA",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Diflunisal (Compound) upregulates HLA-DMA (Gene) and HLA-DMA (Gene) is upregulated by Dasatinib (Compound)
Diflunisal (Compound) downregulates PCNA (Gene) and PCNA (Gene) is downregulated by Dasatinib (Compound)
Diflunisal (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side E... |
DB00771 | DB01238 | 262 | 673 | [
"DDInter397",
"DDInter118"
] | Clidinium | Aripiprazole | Clidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the tr... | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
262,
24,
673
]
],
[
[
262,
24,
1630
],
[
1630,
1,
673
]
],
[
[
262,
6,
7992
],
[
7992,
45,
673
]
],
[
[
262,
24,
537
],
[
537,
2... | [
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Clidinium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Perphenazine"
],
[
... | Clidinium may cause a moderate interaction that could exacerbate diseases when taken with Perphenazine and Perphenazine (Compound) resembles Aripiprazole (Compound)
Clidinium (Compound) binds CHRM1 (Gene) and CHRM1 (Gene) is bound by Aripiprazole (Compound)
Clidinium may cause a moderate interaction that could exacerba... |
DB01097 | DB08916 | 1,377 | 26 | [
"DDInter1033",
"DDInter32"
] | Leflunomide | Afatinib | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor in the form of a dimaleate salt available as Boehringer Ingelheim's brand name Gilotrif [FDA Label]. For oral use, afatinib tablets are a first-line (initial) treatment for patients with metastatic non-small cell lung cancer (NSCLC) with common epidermal grow... | Major | 2 | [
[
[
1377,
25,
26
]
],
[
[
1377,
64,
883
],
[
883,
40,
26
]
],
[
[
1377,
6,
17404
],
[
17404,
45,
26
]
],
[
[
1377,
18,
8386
],
[
8386,
... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Afatinib"
]
],
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Gefitinib"
],
[
"Gefitinib",
"{u} (Co... | Leflunomide may lead to a major life threatening interaction when taken with Gefitinib and Gefitinib (Compound) resembles Afatinib (Compound)
Leflunomide (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Afatinib (Compound)
Leflunomide (Compound) downregulates MTHFD2 (Gene) and MTHFD2 (Gene) is upregulated by ... |
DB00691 | DB00912 | 1,058 | 473 | [
"DDInter1237",
"DDInter1581"
] | Moexipril | Repaglinide | Moexipril is a non-sulfhydryl containing precursor of the active angiotensin-converting enzyme (ACE) inhibitor moexiprilat. It is used to treat high blood pressure (hypertension). It works by relaxing blood vessels, causing them to widen. Lowering high blood pressure helps prevent strokes, heart attacks and kidney prob... | Repaglinide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). It belongs to the meglitinide class of short-acting insulin secretagogues, which act by binding to β cells of the pancreas to stimulate insulin release. Repaglinide induces an early insulin response... | Moderate | 1 | [
[
[
1058,
24,
473
]
],
[
[
1058,
63,
1512
],
[
1512,
24,
473
]
],
[
[
1058,
1,
664
],
[
664,
24,
473
]
],
[
[
1058,
24,
433
],
[
433,
... | [
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Repaglinide"
]
],
[
[
"Moexipril",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diclofenac"
],
[
... | Moexipril may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may cause a moderate interaction that could exacerbate diseases when taken with Repaglinide
Moexipril (Compound) resembles Perindopril (Compound) and Perindopril may cause a moderate interaction that coul... |
DB05015 | DB08826 | 1,077 | 1,292 | [
"DDInter174",
"DDInter489"
] | Belinostat | Deferiprone | Belinostat is a novel agent that inhibits the enzyme histone deacetylase (HDAC) with a sulfonamide-hydroxamide structure. It was developed as an orphan drug to target hematological malignancies and solid tumors by TopoTarget. The safety and efficacy of belinostat is currently being evaluated for use in combination with... | Deferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired. FDA ap... | Major | 2 | [
[
[
1077,
25,
1292
]
],
[
[
1077,
24,
1017
],
[
1017,
63,
1292
]
],
[
[
1077,
63,
482
],
[
482,
25,
1292
]
],
[
[
1077,
24,
1619
],
[
1619... | [
[
[
"Belinostat",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Deferiprone"
]
],
[
[
"Belinostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lorlatinib"
],
[
"Lorlatini... | Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lorlatinib may cause a moderate interaction that could exacerbate diseases when taken with Deferiprone
Belinostat may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tiogu... |
DB00738 | DB01611 | 485 | 1,487 | [
"DDInter1420",
"DDInter893"
] | Pentamidine | Hydroxychloroquine | Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of pneumocystis pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects. | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Major | 2 | [
[
[
485,
25,
1487
]
],
[
[
485,
24,
1520
],
[
1520,
25,
1487
]
],
[
[
485,
6,
12523
],
[
12523,
45,
1487
]
],
[
[
485,
21,
28658
],
[
2865... | [
[
[
"Pentamidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Hydroxychloroquine"
]
],
[
[
"Pentamidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Primaquine"
],
[
"... | Pentamidine may cause a moderate interaction that could exacerbate diseases when taken with Primaquine and Primaquine may lead to a major life threatening interaction when taken with Hydroxychloroquine
Pentamidine (Compound) binds CYP2D6 (Gene) and CYP2D6 (Gene) is bound by Hydroxychloroquine (Compound)
Pentamidine (Co... |
DB00446 | DB08893 | 597 | 271 | [
"DDInter351",
"DDInter1229"
] | Chloramphenicol | Mirabegron | An antibiotic first isolated from cultures of _Streptomyces venezuelae_ in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The E... | Mirabegron is a sympathomimetic beta-3 adrenergic receptor agonist used to relax the smooth muscle of the bladder in the treatment of urinary frequency and incontinence. It is unique amongst overactive bladder treatment options in that, unlike other treatments such as [solifenacin] and [darifenacin], it lacks significa... | Minor | 0 | [
[
[
597,
23,
271
]
],
[
[
597,
24,
371
],
[
371,
40,
271
]
],
[
[
597,
6,
8374
],
[
8374,
45,
271
]
],
[
[
597,
21,
29232
],
[
29232,
... | [
[
[
"Chloramphenicol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Mirabegron"
]
],
[
[
"Chloramphenicol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Propafenone"
],... | Chloramphenicol may cause a moderate interaction that could exacerbate diseases when taken with Propafenone and Propafenone (Compound) resembles Mirabegron (Compound)
Chloramphenicol (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Mirabegron (Compound)
Chloramphenicol (Compound) causes Urticaria (Side Effe... |
DB00328 | DB00620 | 831 | 175 | [
"DDInter921",
"DDInter1855"
] | Indomethacin | Triamcinolone | Indometacin, or indomethacin, is a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic properties. NSAIDs consist of agents that are structurally unrelated; the NSAID chemical classification of indometacin is an indole-acetic acid derivative with the chemical name 1- (p-chlor... | Triamcinolone is a corticosteroid used to treat various inflammatory conditions in the body from allergic rhinitis to acute exacerbations of multiple sclerosis. Triamcinolone can be used as a one time adjunct treatment of osteoarthritic knee pain, or first line as a topical treatment of corticosteroid responsive dermat... | Moderate | 1 | [
[
[
831,
24,
175
]
],
[
[
831,
24,
1573
],
[
1573,
1,
175
]
],
[
[
831,
24,
617
],
[
617,
40,
175
]
],
[
[
831,
10,
11591
],
[
11591,
... | [
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
]
],
[
[
"Indomethacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Prednisone"
],
... | Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Prednisone and Prednisone (Compound) resembles Triamcinolone (Compound)
Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide (Compound) resembles Triamcinolone (... |
DB10429 | DB12001 | 200 | 564 | [
"DDInter282",
"DDInter7"
] | Candida albicans | Abemaciclib | Candida albicans is a fungus which can provoke allergic reactions. Candida albicans is used in allergenic testing. | Abemaciclib is an antitumor agent and dual inhibitor of cyclin-dependent kinases 4 (CDK4) and 6 (CDK6) that are involved in the cell cycle and promotion of cancer cell growth in case of unregulated activity. On September 28, 2017, FDA granted approval of abemaciclib treatment under the market name Verzenio for the trea... | Moderate | 1 | [
[
[
200,
24,
564
]
],
[
[
200,
63,
58
],
[
58,
24,
564
]
],
[
[
200,
24,
351
],
[
351,
24,
564
]
],
[
[
200,
24,
1476
],
[
1476,
63,... | [
[
[
"Candida albicans",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Abemaciclib"
]
],
[
[
"Candida albicans",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alefacept"
... | Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Alefacept and Alefacept may cause a moderate interaction that could exacerbate diseases when taken with Abemaciclib
Candida albicans may cause a moderate interaction that could exacerbate diseases when taken with Ribociclib... |
DB00196 | DB00641 | 600 | 467 | [
"DDInter743",
"DDInter1675"
] | Fluconazole | Simvastatin | Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itraconazole]. Fluconazole ... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Major | 2 | [
[
[
600,
25,
467
]
],
[
[
600,
6,
8374
],
[
8374,
45,
467
]
],
[
[
600,
18,
8368
],
[
8368,
57,
467
]
],
[
[
600,
21,
28810
],
[
28810,
... | [
[
[
"Fluconazole",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Simvastatin"
]
],
[
[
"Fluconazole",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Simv... | Fluconazole (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Simvastatin (Compound)
Fluconazole (Compound) downregulates DNTTIP2 (Gene) and DNTTIP2 (Gene) is downregulated by Simvastatin (Compound)
Fluconazole (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is c... |
DB00087 | DB00432 | 599 | 1,083 | [
"DDInter41",
"DDInter1868"
] | Alemtuzumab | Trifluridine | Alemtuzumab is a humanized monoclonal antibody specific to lymphocyte antigens. It is a recombinant DNA-derived humanized monoclonal antibody (Campath-1H) that is directed against the 21-28 kD cell surface glycoprotein, CD52. The Campath-1H antibody is an IgG1 kappa with the human variable framework and constant region... | Trifluridine is a fluorinated pyrimidine nucleoside that is structurally related to [idoxuridine] . It is an active antiviral agent in ophthalmic solutions used mainly in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis due to herpes simplex virus. It displays effective antiviral activit... | Moderate | 1 | [
[
[
599,
24,
1083
]
],
[
[
599,
24,
1238
],
[
1238,
1,
1083
]
],
[
[
599,
24,
139
],
[
139,
63,
1083
]
],
[
[
599,
63,
1257
],
[
1257,
... | [
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
]
],
[
[
"Alemtuzumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
],
... | Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Pentostatin and Pentostatin (Compound) resembles Trifluridine (Compound)
Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Zidovudine and Zidovudine may cause a moderate interaction that... |
DB00867 | DB06616 | 1,052 | 594 | [
"DDInter1606",
"DDInter224"
] | Ritodrine | Bosutinib | Adrenergic beta-agonist used to control premature labor. | Bosutinib is a 7-alkoxy-3-quinolinecarbonitrile that functions as a potent, dual SRC and ABL tyrosine kinase inhibitor indicated for chronic myelogenous leukemia (CML), specifically Philadelphia chromosome-positive (Ph+) CML. Philadelphia chromosome is a hallmark of CML due to the reciprocal translocation t(9;22)(q34;q... | Moderate | 1 | [
[
[
1052,
24,
594
]
],
[
[
1052,
24,
1559
],
[
1559,
24,
594
]
],
[
[
1052,
24,
774
],
[
774,
63,
594
]
],
[
[
1052,
63,
485
],
[
485,
... | [
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bosutinib"
]
],
[
[
"Ritodrine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Famotidine"
],
[
... | Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Famotidine and Famotidine may cause a moderate interaction that could exacerbate diseases when taken with Bosutinib
Ritodrine may cause a moderate interaction that could exacerbate diseases when taken with Degarelix and Degarelix ... |
DB00250 | DB00995 | 10 | 1,112 | [
"DDInter475",
"DDInter139"
] | Dapsone | Auranofin | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Auranofin is a gold salt that is capable of eliciting pharmacologic actions that suppress inflammation and stimulate cell-mediated immunity. It has subsequently been listed by the World Health Organization as a member of the antirheumatic agent category. Auranofin appears to induce heme oxygenase 1 (HO-1) mRNA. Heme ox... | Moderate | 1 | [
[
[
10,
24,
1112
]
],
[
[
10,
6,
7720
],
[
7720,
46,
1112
]
],
[
[
10,
21,
28694
],
[
28694,
60,
1112
]
],
[
[
10,
24,
36
],
[
36,
6... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Auranofin"
]
],
[
[
"Dapsone",
"{u} (Compound) binds {v} (Gene)",
"PTGS2"
],
[
"PTGS2",
"{u} (Gene) is upregulated by {v} (Compound)",
... | Dapsone (Compound) binds PTGS2 (Gene) and PTGS2 (Gene) is upregulated by Auranofin (Compound)
Dapsone (Compound) causes Proteinuria (Side Effect) and Proteinuria (Side Effect) is caused by Auranofin (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Eribulin and Eribulin ... |
DB01240 | DB04932 | 885 | 1,564 | [
"DDInter657",
"DDInter491"
] | Epoprostenol | Defibrotide | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Defibrotide is the sodium salt of a mixture of single-stranded oligodeoxyribonucleotides derived from porcine mucosal DNA. It has been shown to have antithrombotic, anti-inflammatory and anti-ischemic properties (but without associated significant systemic anticoagulant effects). It is marketed under the brand names Da... | Moderate | 1 | [
[
[
885,
24,
1564
]
],
[
[
885,
23,
539
],
[
539,
62,
1564
]
],
[
[
885,
63,
914
],
[
914,
24,
1564
]
],
[
[
885,
24,
41
],
[
41,
63... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Defibrotide"
]
],
[
[
"Epoprostenol",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Capsicum"
],
[
... | Epoprostenol may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cause a minor interaction that can limit clinical effects when taken with Defibrotide
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Diflunisal and Diflunisa... |
DB01087 | DB09020 | 1,520 | 28 | [
"DDInter1520",
"DDInter212"
] | Primaquine | Bisacodyl | An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Ad... | Bisacodyl, a diphenylmethane derivative, is a commonly used over the counter stimulant laxative for occasional constipation.[A233300,L13362] Both bisacodyl and [picosulfate] are metabolized to the same active metabolite bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM).[A233290,A233300,A207700] Bisacodyl was patented on 2... | Moderate | 1 | [
[
[
1520,
24,
28
]
],
[
[
1520,
6,
9842
],
[
9842,
46,
28
]
],
[
[
1520,
21,
28722
],
[
28722,
60,
28
]
],
[
[
1520,
63,
739
],
[
739,
... | [
[
[
"Primaquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bisacodyl"
]
],
[
[
"Primaquine",
"{u} (Compound) binds {v} (Gene)",
"CYP1A1"
],
[
"CYP1A1",
"{u} (Gene) is upregulated by {v} (Compou... | Primaquine (Compound) binds CYP1A1 (Gene) and CYP1A1 (Gene) is upregulated by Bisacodyl (Compound)
Primaquine (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Bisacodyl (Compound)
Primaquine may cause a moderate interaction that could exacerbate diseases when taken with Lomefloxacin and Lome... |
DB00182 | DB00279 | 80 | 1,152 | [
"DDInter84",
"DDInter1074"
] | Amphetamine | Liothyronine | Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 ... | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Moderate | 1 | [
[
[
80,
24,
1152
]
],
[
[
80,
40,
11215
],
[
11215,
40,
1152
]
],
[
[
80,
24,
542
],
[
542,
40,
1152
]
],
[
[
80,
21,
29118
],
[
29118,
... | [
[
[
"Amphetamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
]
],
[
[
"Amphetamine",
"{u} (Compound) resembles {v} (Compound)",
"L-Phenylalanine"
],
[
"L-Phenylalanine",
"{u} (Comp... | Amphetamine (Compound) resembles L-Phenylalanine (Compound) and L-Phenylalanine (Compound) resembles Liothyronine (Compound)
Amphetamine may cause a moderate interaction that could exacerbate diseases when taken with Levothyroxine and Levothyroxine (Compound) resembles Liothyronine (Compound)
Amphetamine (Compound) cau... |
DB00712 | DB03128 | 1,274 | 140 | [
"DDInter764",
"DDInter18"
] | Flurbiprofen (ophthalmic) | Acetylcholine | Flurbiprofen can cause developmental toxicity and female reproductive toxicity according to state or federal government labeling requirements. | A neurotransmitter. Acetylcholine in vertebrates is the major transmitter at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. It is generally not used as an administered drug because it is broken ... | Minor | 0 | [
[
[
1274,
23,
140
]
],
[
[
1274,
24,
762
],
[
762,
63,
1376
],
[
1376,
24,
140
]
],
[
[
1274,
24,
996
],
[
996,
40,
1376
],
[
1376,
24,
... | [
[
[
"Flurbiprofen",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Acetylcholine"
]
],
[
[
"Flurbiprofen",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bepridil"
],
[... | Flurbiprofen may cause a minor interaction that can limit clinical effects when taken with Acetylcholine
Flurbiprofen may cause a moderate interaction that could exacerbate diseases when taken with Bepridil and Bepridil may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and ... |
DB04844 | DB09241 | 843 | 1,629 | [
"DDInter1778",
"DDInter1186"
] | Tetrabenazine | Methylene blue | A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008. | Methylene blue is an oxidation-reduction agent. The intravenous form of methylene blue is approved by the FDA for the treatment of pediatric and adult patients with acquired methemoglobinemia. Historically, it has been widely used in Africa to treat malaria, but now it disappeared when chloroquine (CQ) and other drugs ... | Major | 2 | [
[
[
843,
25,
1629
]
],
[
[
843,
63,
1148
],
[
1148,
24,
1629
]
],
[
[
843,
24,
659
],
[
659,
24,
1629
]
],
[
[
843,
64,
1311
],
[
1311,
... | [
[
[
"Tetrabenazine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Methylene blue"
]
],
[
[
"Tetrabenazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Isoprenaline"
],
[
... | Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Isoprenaline and Isoprenaline may cause a moderate interaction that could exacerbate diseases when taken with Methylene blue
Tetrabenazine may cause a moderate interaction that could exacerbate diseases when taken with Vilante... |
DB01075 | DB01173 | 1,376 | 358 | [
"DDInter569",
"DDInter1349"
] | Diphenhydramine | Orphenadrine | Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies, insect bites and stings, and rashes [L5263, L5266, L5269, F3379]. However, it also has antiemetic, antitussive, hypnoti... | A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm. | Moderate | 1 | [
[
[
1376,
35,
358
]
],
[
[
1376,
63,
211
],
[
211,
1,
358
]
],
[
[
1376,
1,
11268
],
[
11268,
1,
358
]
],
[
[
1376,
35,
272
],
[
272,
... | [
[
[
"Diphenhydramine",
"{u} (Compound) resembles {v} (Compound) and {u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orphenadrine"
]
],
[
[
"Diphenhydramine",
"{u} may cause a moderate interaction that could exacerbate diseases ... | Diphenhydramine (Compound) resembles Orphenadrine (Compound) and
Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Tolterodine and Tolterodine (Compound) resembles Orphenadrine (Compound)
Diphenhydramine (Compound) resembles Cloperastine (Compound) and Cloperastine (Compoun... |
DB00350 | DB01403 | 1,214 | 9 | [
"DDInter1226",
"DDInter1175"
] | Minoxidil | Methotrimeprazine | A potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure. | A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604) | Moderate | 1 | [
[
[
1214,
24,
9
]
],
[
[
1214,
24,
1178
],
[
1178,
40,
9
]
],
[
[
1214,
24,
1164
],
[
1164,
1,
9
]
],
[
[
1214,
24,
401
],
[
401,
24... | [
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methotrimeprazine"
]
],
[
[
"Minoxidil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluoperazine"
]... | Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Trifluoperazine and Trifluoperazine (Compound) resembles Methotrimeprazine (Compound)
Minoxidil may cause a moderate interaction that could exacerbate diseases when taken with Trimipramine and Trimipramine (Compound) resembles Met... |
DB00615 | DB05812 | 690 | 1,374 | [
"DDInter1589",
"DDInter8"
] | Rifabutin | Abiraterone | A broad-spectrum antibiotic that is being used as prophylaxis against disseminated Mycobacterium avium complex infection in HIV-positive patients. | Abiraterone is a potent, irreversible, and selective inhibitor of 17 αhydroxylase/C17,20-lyase (CYP17), an enzyme expressed in testicular, adrenal, and prostatic tumour tissues, to regulate androgen biosynthesis.[A3811, A260880, L40968] Abiraterone was first approved by the FDA and EMA on April, July, and September 201... | Major | 2 | [
[
[
690,
25,
1374
]
],
[
[
690,
6,
8374
],
[
8374,
45,
1374
]
],
[
[
690,
21,
28940
],
[
28940,
60,
1374
]
],
[
[
690,
24,
466
],
[
466,
... | [
[
[
"Rifabutin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Abiraterone"
]
],
[
[
"Rifabutin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Abirater... | Rifabutin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Abiraterone (Compound)
Rifabutin (Compound) causes Blood alkaline phosphatase increased (Side Effect) and Blood alkaline phosphatase increased (Side Effect) is caused by Abiraterone (Compound)
Rifabutin may cause a moderate interaction that could ex... |
DB00757 | DB01128 | 1,166 | 918 | [
"DDInter581",
"DDInter204"
] | Dolasetron | Bicalutamide | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor. | Major | 2 | [
[
[
1166,
25,
918
]
],
[
[
1166,
25,
129
],
[
129,
40,
918
]
],
[
[
1166,
6,
8374
],
[
8374,
45,
918
]
],
[
[
1166,
21,
28642
],
[
28642,
... | [
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bicalutamide"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide",
... | Dolasetron may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide (Compound) resembles Bicalutamide (Compound)
Dolasetron (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Bicalutamide (Compound)
Dolasetron (Compound) causes Shock (Side Effect) and Shock (Side Effect) ... |
DB00563 | DB13886 | 663 | 125 | [
"DDInter1174",
"DDInter870"
] | Methotrexate | Human cytomegalovirus immune globulin | Methotrexate is a folate derivative that inhibits several enzymes responsible for nucleotide synthesis. This inhibition leads to suppression of inflammation as well as prevention of cell division. Because of these effects, methotrexate is often used to treat inflammation caused by arthritis or to control cell division ... | Cytomegalovirus immunoglobulin is obtained from pooled adult human plasma selected for high titers of antibody for cytomegalovirus (CMV). It contains purified immunoglobulin G (IgG) antibodies targeting cytomegalovirus (CMV)[FDA label]. Cytomegalovirus, a member of the herpes virus family, is ubiquitous the human popul... | Major | 2 | [
[
[
663,
25,
125
]
],
[
[
663,
25,
1512
],
[
1512,
25,
125
]
],
[
[
663,
24,
712
],
[
712,
25,
125
]
],
[
[
663,
63,
589
],
[
589,
2... | [
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Human cytomegalovirus immune globulin"
]
],
[
[
"Methotrexate",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Diclofenac"
],
[
... | Methotrexate may lead to a major life threatening interaction when taken with Diclofenac and Diclofenac may lead to a major life threatening interaction when taken with Human cytomegalovirus immune globulin
Methotrexate may cause a moderate interaction that could exacerbate diseases when taken with Olsalazine and Olsal... |
DB00095 | DB13915 | 66 | 689 | [
"DDInter623",
"DDInter146"
] | Efalizumab | Axicabtagene ciloleucel | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Axicabtagene ciloleucel is an anti-CD19 chimeric antigen receptor (CAR) T-cell therapy. The drug has a unique mechanism of action, as it utilizes the patient's own T cells, which play a central role in immune response to cancer. Once T-cells are collected from the patient, they are genetically engineered to express ant... | Moderate | 1 | [
[
[
66,
24,
689
]
],
[
[
66,
63,
599
],
[
599,
24,
689
]
],
[
[
66,
24,
270
],
[
270,
24,
689
]
],
[
[
66,
25,
976
],
[
976,
25,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Axicabtagene ciloleucel"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Axicabtagene ciloleucel
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Ocreli... |
DB00279 | DB06335 | 1,152 | 761 | [
"DDInter1074",
"DDInter1646"
] | Liothyronine | Saxagliptin | Liothyronine is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Liothyronine is the active form of thyroxine which is composed in a basic chemical structure by a tyrosine with bound iodine. The exogenous liothyronine product was developed by King Pharmace... | Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009. | Moderate | 1 | [
[
[
1152,
24,
761
]
],
[
[
1152,
6,
16560
],
[
16560,
45,
761
]
],
[
[
1152,
24,
1296
],
[
1296,
63,
761
]
],
[
[
1152,
24,
1445
],
[
1445... | [
[
[
"Liothyronine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Saxagliptin"
]
],
[
[
"Liothyronine",
"{u} (Compound) binds {v} (Gene)",
"SLC22A8"
],
[
"SLC22A8",
"{u} (Gene) is bound by {v} (Comp... | Liothyronine (Compound) binds SLC22A8 (Gene) and SLC22A8 (Gene) is bound by Saxagliptin (Compound)
Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Insulin degludec and Insulin degludec may cause a moderate interaction that could exacerbate diseases when taken with Saxaglipti... |
DB00095 | DB00552 | 66 | 1,238 | [
"DDInter623",
"DDInter1425"
] | Efalizumab | Pentostatin | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | A potent inhibitor of adenosine deaminase. The drug is effective in the treatment of many lymphoproliferative malignancies, particularly hairy-cell leukemia. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity. | Moderate | 1 | [
[
[
66,
24,
1238
]
],
[
[
66,
24,
1083
],
[
1083,
40,
1238
]
],
[
[
66,
24,
1426
],
[
1426,
1,
1238
]
],
[
[
66,
63,
1648
],
[
1648,
... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentostatin"
]
],
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Trifluridine"
],
[... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Trifluridine and Trifluridine (Compound) resembles Pentostatin (Compound)
Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Azacitidine and Azacitidine (Compound) resembles Pentostatin (Co... |
DB06203 | DB09100 | 1,002 | 320 | [
"DDInter51",
"DDInter1799"
] | Alogliptin | Thyroid, porcine | Alogliptin is a selective, orally-bioavailable inhibitor of enzymatic activity of dipeptidyl peptidase-4 (DPP-4). Chemically, alogliptin is prepared as a benzoate salt and exists predominantly as the R-enantiomer (>99%). It undergoes little or no chiral conversion in vivo to the (S)-enantiomer. FDA approved January 25,... | Thyroid extract is dried and powdered thyroid glands from pigs containing tiiodothyronine (T3) and thyroxine (T4) used to supplement low or absent thyroid activity.[A190831,L11755] Thyroid extract has been described in literature to treat hypothyroidism since 1891 but its use dates back as far as the 6th century. Thyro... | Moderate | 1 | [
[
[
1002,
24,
320
]
],
[
[
1002,
63,
417
],
[
417,
23,
320
]
],
[
[
1002,
63,
1144
],
[
1144,
24,
320
]
],
[
[
1002,
24,
1296
],
[
1296,
... | [
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Thyroid, porcine"
]
],
[
[
"Alogliptin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sucralfate"
],
... | Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Sucralfate and Sucralfate may cause a minor interaction that can limit clinical effects when taken with Thyroid, porcine
Alogliptin may cause a moderate interaction that could exacerbate diseases when taken with Nateglinide and N... |
DB00427 | DB00564 | 1,233 | 1,236 | [
"DDInter1879",
"DDInter293"
] | Triprolidine | Carbamazepine | First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness. | Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbam... | Moderate | 1 | [
[
[
1233,
24,
1236
]
],
[
[
1233,
24,
1405
],
[
1405,
40,
1236
]
],
[
[
1233,
63,
508
],
[
508,
1,
1236
]
],
[
[
1233,
24,
104
],
[
104,
... | [
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbamazepine"
]
],
[
[
"Triprolidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclobenzaprine"
... | Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Cyclobenzaprine and Cyclobenzaprine (Compound) resembles Carbamazepine (Compound)
Triprolidine may cause a moderate interaction that could exacerbate diseases when taken with Promazine and Promazine (Compound) resembles Carbama... |
DB06595 | DB06688 | 1,491 | 1,430 | [
"DDInter1214",
"DDInter1677"
] | Midostaurin | Sipuleucel-T | Midostaurin (as Rydapt) is a multitarget kinase inhibitor for the treatment for adult patients with newly diagnosed acute myeloid leukemia (AML) who have a specific genetic mutation called FLT3. It was initially characterized as a potential broad-spectrum antineoplastic agent, with activity toward diverse solid and hem... | Sipuleucel-T is a personalized, autologous, cellular immunotherapy. Sipuleucel-T is a therapeutic cancer vaccine for prostate cancer. Sipuleucel-T selectively targets the prostate-specific antigen (PSA) known as prostatic acid phosphatase (PAP) that is expressed in around 95% of prostate cancers. It must be prepared sp... | Moderate | 1 | [
[
[
1491,
24,
1430
]
],
[
[
1491,
63,
51
],
[
51,
24,
1430
]
],
[
[
1491,
25,
676
],
[
676,
63,
1430
]
],
[
[
1491,
24,
310
],
[
310,
... | [
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sipuleucel-T"
]
],
[
[
"Midostaurin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Daunorubicin"
],
... | Midostaurin may cause a moderate interaction that could exacerbate diseases when taken with Daunorubicin and Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken with Sipuleucel-T
Midostaurin may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitini... |
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