drug1_db stringlengths 7 7 | drug2_db stringlengths 7 7 | drug1_id int64 0 1.69k | drug2_id int64 0 1.69k | drug_pair listlengths 2 2 | drug1_name stringlengths 4 85 | drug2_name stringlengths 4 85 | drug1_desc stringlengths 27 1.09k | drug2_desc stringlengths 27 6.14k | label stringclasses 3
values | label_idx int64 0 2 | all_paths listlengths 1 10 | all_paths_str listlengths 1 10 | path_str stringlengths 0 3.57k |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB00445 | DB00766 | 322 | 1,675 | [
"DDInter655",
"DDInter394"
] | Epirubicin | Clavulanic acid | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with [Amoxicillin] or [Ticarcillin] to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections. Clavulanic acid is derived from the organism Streptomyces... | Moderate | 1 | [
[
[
322,
24,
1675
]
],
[
[
322,
21,
28931
],
[
28931,
60,
1675
]
],
[
[
322,
24,
850
],
[
850,
63,
1675
]
],
[
[
322,
63,
482
],
[
482,
... | [
[
[
"Epirubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clavulanic acid"
]
],
[
[
"Epirubicin",
"{u} (Compound) causes {v} (Side Effect)",
"Haemorrhage"
],
[
"Haemorrhage",
"{u} (Side Effect... | Epirubicin (Compound) causes Haemorrhage (Side Effect) and Haemorrhage (Side Effect) is caused by Clavulanic acid (Compound)
Epirubicin may cause a moderate interaction that could exacerbate diseases when taken with Brentuximab vedotin and Brentuximab vedotin may cause a moderate interaction that could exacerbate disea... |
DB00215 | DB11986 | 1,230 | 484 | [
"DDInter388",
"DDInter648"
] | Citalopram | Entrectinib | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positi... | Major | 2 | [
[
[
1230,
25,
484
]
],
[
[
1230,
23,
112
],
[
112,
23,
484
]
],
[
[
1230,
25,
222
],
[
222,
23,
484
]
],
[
[
1230,
25,
774
],
[
774,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Entrectinib"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metronid... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Entrectinib
Citalopram may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may c... |
DB00704 | DB05528 | 267 | 1,070 | [
"DDInter1263",
"DDInter1228"
] | Naltrexone | Mipomersen | Derivative of noroxymorphone that is the N-cyclopropylmethyl congener of naloxone. It is a narcotic antagonist that is effective orally, longer lasting and more potent than naloxone, and has been proposed for the treatment of heroin addiction. The FDA has approved naltrexone for the treatment of alcohol dependence. | Mipomersen sodium, which was known as the investigational drug, isis-301012, is the salt form of a synthetic phosphorothioate oligonucleotide. Mipomersen sodium prevents the formation of apo B-100, resulting in a decrease in the levels of apolipoprotein B (apo B), low density lipoprotein (LDL), and total cholesterol. M... | Major | 2 | [
[
[
267,
25,
1070
]
],
[
[
267,
24,
292
],
[
292,
64,
1070
]
],
[
[
267,
63,
1512
],
[
1512,
25,
1070
]
],
[
[
267,
24,
14
],
[
14,
... | [
[
[
"Naltrexone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Mipomersen"
]
],
[
[
"Naltrexone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Regorafenib"
],
[
"Regorafen... | Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Regorafenib and Regorafenib may lead to a major life threatening interaction when taken with Mipomersen
Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Diclofenac and Diclofenac may lead... |
DB01097 | DB01219 | 1,377 | 716 | [
"DDInter1033",
"DDInter473"
] | Leflunomide | Dantrolene | Leflunomide is a pyrimidine synthesis inhibitor belonging to the DMARD (disease-modifying antirheumatic drug) class of drugs, which are chemically and pharmacologically very heterogeneous. Leflunomide was approved by FDA and in many other countries (e.g., Canada, Europe) in 1999. | Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin. | Major | 2 | [
[
[
1377,
25,
716
]
],
[
[
1377,
21,
28698
],
[
28698,
60,
716
]
],
[
[
1377,
64,
267
],
[
267,
24,
716
]
],
[
[
1377,
25,
1613
],
[
1613,... | [
[
[
"Leflunomide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dantrolene"
]
],
[
[
"Leflunomide",
"{u} (Compound) causes {v} (Side Effect)",
"Insomnia"
],
[
"Insomnia",
"{u} (Side Effect) is caused by {v} (Comp... | Leflunomide (Compound) causes Insomnia (Side Effect) and Insomnia (Side Effect) is caused by Dantrolene (Compound)
Leflunomide may lead to a major life threatening interaction when taken with Naltrexone and Naltrexone may cause a moderate interaction that could exacerbate diseases when taken with Dantrolene
Leflunomide... |
DB00374 | DB14006 | 1,061 | 972 | [
"DDInter1852",
"DDInter370"
] | Treprostinil | Choline salicylate | Treprostinil is a stable tricyclic analogue of prostacyclin that promotes the vasodilation of pulmonary and systemic arterial vascular beds and the inhibition of platelet aggregation.[L41855,L41860,L41865] It reduces symptoms in patients with pulmonary arterial hypertension (PAH) and pulmonary hypertension associated w... | Choline salicylate is an anti-inflammatory pain reliever agent that is related to aspirin. It is used to decrease swelling and to treat mild-moderate pain. It is used to treat arthritis in both children and adults. This medicine can also be used for fever . Choline Salicylate is the choline salt of salicylic acid, used... | Moderate | 1 | [
[
[
1061,
24,
972
]
],
[
[
1061,
25,
553
],
[
553,
24,
972
]
],
[
[
1061,
63,
291
],
[
291,
24,
972
]
],
[
[
1061,
1,
885
],
[
885,
... | [
[
[
"Treprostinil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Choline salicylate"
]
],
[
[
"Treprostinil",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Fondaparinux"
],
[
... | Treprostinil may lead to a major life threatening interaction when taken with Fondaparinux and Fondaparinux may cause a moderate interaction that could exacerbate diseases when taken with Choline salicylate
Treprostinil may cause a moderate interaction that could exacerbate diseases when taken with Argatroban and Argat... |
DB00046 | DB00263 | 1,179 | 1,029 | [
"DDInter940",
"DDInter1727"
] | Insulin lispro | Sulfisoxazole | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. | Moderate | 1 | [
[
[
1179,
24,
1029
]
],
[
[
1179,
24,
1247
],
[
1247,
40,
1029
]
],
[
[
1179,
24,
161
],
[
161,
1,
1029
]
],
[
[
1179,
24,
245
],
[
245,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfisoxazole"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sulfamethoxazole... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sulfamethoxazole and Sulfamethoxazole (Compound) resembles Sulfisoxazole (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Sulfadiazine and Sulfadiazine (Compound) resem... |
DB00883 | DB06292 | 426 | 549 | [
"DDInter989",
"DDInter474"
] | Isosorbide dinitrate | Dapagliflozin | A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. | Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor, and it was the first SLGT2 inhibitor to be approved. indicated for managing diabetes mellitus type 2. When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose reabsorption in the proximal tu... | Moderate | 1 | [
[
[
426,
24,
549
]
],
[
[
426,
24,
1344
],
[
1344,
40,
549
]
],
[
[
426,
6,
8374
],
[
8374,
45,
549
]
],
[
[
426,
21,
28787
],
[
28787,
... | [
[
[
"Isosorbide dinitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dapagliflozin"
]
],
[
[
"Isosorbide dinitrate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cana... | Isosorbide dinitrate may cause a moderate interaction that could exacerbate diseases when taken with Canagliflozin and Canagliflozin (Compound) resembles Dapagliflozin (Compound)
Isosorbide dinitrate (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Dapagliflozin (Compound)
Isosorbide dinitrate (Compound) ca... |
DB00647 | DB00747 | 675 | 1,442 | [
"DDInter528",
"DDInter1647"
] | Dextropropoxyphene | Scopolamine | Dextropropoxyphene is an opioid analgesic manufactured by Eli Lilly and Company. It is used in the symptomatic treatment of mild pain. It displays antitussive and local anaesthetic actions. Due to the risk of cardiac arrhythmias and overdose, possibly leading to death, dextropropoxyphene has been withdrawn from the mar... | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Major | 2 | [
[
[
675,
25,
1442
]
],
[
[
675,
63,
19
],
[
19,
24,
1442
]
],
[
[
675,
21,
28766
],
[
28766,
60,
1442
]
],
[
[
675,
24,
543
],
[
543,
... | [
[
[
"Dextropropoxyphene",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Scopolamine"
]
],
[
[
"Dextropropoxyphene",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hyoscyamine"
],
[... | Dextropropoxyphene may cause a moderate interaction that could exacerbate diseases when taken with Hyoscyamine and Hyoscyamine may cause a moderate interaction that could exacerbate diseases when taken with Scopolamine
Dextropropoxyphene (Compound) causes Hypotension (Side Effect) and Hypotension (Side Effect) is cause... |
DB00372 | DB01324 | 999 | 178 | [
"DDInter1793",
"DDInter1490"
] | Thiethylperazine | Polythiazide | A dopamine antagonist that is particularly useful in treating the nausea and vomiting associated with anesthesia, mildly emetic cancer chemotherapy agents, radiation therapy, and toxins. This piperazine phenothiazine does not prevent vertigo or motion sickness. (From AMA Drug Evaluations Annual, 1994, p457) | A thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p826) | Moderate | 1 | [
[
[
999,
24,
178
]
],
[
[
999,
24,
504
],
[
504,
40,
178
]
],
[
[
999,
24,
85
],
[
85,
23,
178
]
],
[
[
999,
63,
352
],
[
352,
23,
... | [
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Polythiazide"
]
],
[
[
"Thiethylperazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydrochloroth... | Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Hydrochlorothiazide and Hydrochlorothiazide (Compound) resembles Polythiazide (Compound)
Thiethylperazine may cause a moderate interaction that could exacerbate diseases when taken with Atropine and Atropine may cause a min... |
DB01101 | DB06674 | 60 | 908 | [
"DDInter285",
"DDInter837"
] | Capecitabine | Golimumab | Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. | Golimumab is a human IgG1қ monoclonal antibody derived from immunizing genetically engineered mice with human TNFα. Golimumab binds and inhibits soluble and transmembrane human TNFα. Increased TNFα is associated with chronic inflammation. Thus golimumab is indicated for use in adults (i) as an adjunct to methotrexate t... | Major | 2 | [
[
[
60,
25,
908
]
],
[
[
60,
63,
1461
],
[
1461,
23,
908
]
],
[
[
60,
24,
651
],
[
651,
24,
908
]
],
[
[
60,
63,
208
],
[
208,
24,
... | [
[
[
"Capecitabine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Golimumab"
]
],
[
[
"Capecitabine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Golimumab
Capecitabine may cause a moderate interaction that could exacerbate diseases when taken with Fosphenytoin and Fosph... |
DB01118 | DB01344 | 33 | 1,231 | [
"DDInter76",
"DDInter1830"
] | Amiodarone | Tolevamer | Amiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation. Because of its ability to cause serious toxic... | Sodium polystyrene sulfonate is a medication used to treat abnormally high potassium levels. It may be taken orally or by rectum, as an enema, and functions as a potassium-binding resin in the intestines. It is also an effective topical microbicide and spermicide, inhibiting the genital transfection of, among others, H... | Major | 2 | [
[
[
33,
25,
1231
]
],
[
[
33,
63,
1152
],
[
1152,
24,
1231
]
],
[
[
33,
64,
870
],
[
870,
24,
1231
]
],
[
[
33,
25,
708
],
[
708,
24... | [
[
[
"Amiodarone",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Tolevamer"
]
],
[
[
"Amiodarone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Liothyronine"
],
[
"Liothyron... | Amiodarone may cause a moderate interaction that could exacerbate diseases when taken with Liothyronine and Liothyronine may cause a moderate interaction that could exacerbate diseases when taken with Tolevamer
Amiodarone may lead to a major life threatening interaction when taken with Fludrocortisone and Fludrocortiso... |
DB00501 | DB08820 | 752 | 1,478 | [
"DDInter380",
"DDInter997"
] | Cimetidine | Ivacaftor | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012, and by Health Canada in late 2012. Ivacaftor is administered as a monotherapy and... | Moderate | 1 | [
[
[
752,
24,
1478
]
],
[
[
752,
6,
8374
],
[
8374,
45,
1478
]
],
[
[
752,
21,
28762
],
[
28762,
60,
1478
]
],
[
[
752,
23,
907
],
[
907,
... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ivacaftor"
]
],
[
[
"Cimetidine",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
... | Cimetidine (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Ivacaftor (Compound)
Cimetidine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Ivacaftor (Compound)
Cimetidine may cause a minor interaction that can limit clinical effects when taken with Doravirine and Doravirine... |
DB00398 | DB01175 | 79 | 318 | [
"DDInter1702",
"DDInter672"
] | Sorafenib | Escitalopram | Sorafenib is a bi-aryl urea and an oral multikinase inhibitor. It targets cell surface tyrosine kinase receptors and downstream intracellular kinases that are implicated in tumour cell proliferation and tumour angiogenesis. First approved by the FDA and European Commission in 2007 for the treatment of hepatocellular ca... | Escitalopram is a selective serotonin re-uptake inhibitor (SSRI) and the S-enantiomer of racemic [citalopram]. It is used to restore serotonergic function in the treatment of depression and anxiety.[L8513,L8516,L8522] Escitalopram is approximately 150 times more potent than citalopram’s R-enantiomer and is responsible ... | Major | 2 | [
[
[
79,
25,
318
]
],
[
[
79,
64,
1230
],
[
1230,
1,
318
]
],
[
[
79,
6,
8374
],
[
8374,
45,
318
]
],
[
[
79,
21,
29276
],
[
29276,
6... | [
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
]
],
[
[
"Sorafenib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Citalopram"
],
[
"Citalopram",
"{u} (... | Sorafenib may lead to a major life threatening interaction when taken with Citalopram and Citalopram (Compound) resembles Escitalopram (Compound)
Sorafenib (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Escitalopram (Compound)
Sorafenib (Compound) causes Haemoglobin (Side Effect) and Haemoglobin (Side Eff... |
DB08899 | DB15091 | 129 | 676 | [
"DDInter649",
"DDInter1901"
] | Enzalutamide | Upadacitinib | Enzalutamide is an androgen receptor (AR) inhibitor for the treatment of castration-resistant prostate cancer (CRPC), both metastatic and non-metastatic. It is a second-generation antiandrogen agent that the FDA approved on August 31, 2012.[L40639, A252667] Although androgen deprivation therapy (ADT) is the first-line ... | Upadacitinib is an oral Janus kinase (JAK)1-selective inhibitor and a disease-modifying antirheumatic drug (DMARD) used in the treatment of rheumatoid arthritis to slow down disease progression. Rheumatoid arthritis is a chronic autoimmune inflammatory disease affecting the peripheral joints. It is characterized by syn... | Major | 2 | [
[
[
129,
25,
676
]
],
[
[
129,
63,
1249
],
[
1249,
24,
676
]
],
[
[
129,
25,
283
],
[
283,
24,
676
]
],
[
[
129,
64,
1593
],
[
1593,
... | [
[
[
"Enzalutamide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
]
],
[
[
"Enzalutamide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nafcillin"
],
[
"Nafci... | Enzalutamide may cause a moderate interaction that could exacerbate diseases when taken with Nafcillin and Nafcillin may cause a moderate interaction that could exacerbate diseases when taken with Upadacitinib
Enzalutamide may lead to a major life threatening interaction when taken with Fedratinib and Fedratinib may ca... |
DB00512 | DB01249 | 91 | 258 | [
"DDInter1916",
"DDInter958"
] | Vancomycin | Iodixanol | Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to ristocetin that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear. As of January 29 2018, CutisPharma's Firvanq is the only FDA approved vancomycin oral liquid treatment option available for the the treatm... | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Major | 2 | [
[
[
91,
25,
258
]
],
[
[
91,
25,
497
],
[
497,
1,
258
]
],
[
[
91,
21,
28748
],
[
28748,
60,
258
]
],
[
[
91,
24,
1680
],
[
1680,
24... | [
[
[
"Vancomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iodixanol"
]
],
[
[
"Vancomycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
],
[
"Iohexol",
"{u} (Compoun... | Vancomycin may lead to a major life threatening interaction when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Vancomycin (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Vancomycin may cause a moderate interaction that could exacerbate disea... |
DB00889 | DB15982 | 1,133 | 1,339 | [
"DDInter840",
"DDInter193"
] | Granisetron | Berotralstat | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Berotralstat is a selective inhibitor of plasma kallikrein used in the prophylaxis of attacks of hereditary angioedema (HAE). It works by blocking the enzymatic activity of plasma kallikrein in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE. Berotralstat ... | Moderate | 1 | [
[
[
1133,
24,
1339
]
],
[
[
1133,
63,
1101
],
[
1101,
23,
1339
]
],
[
[
1133,
25,
222
],
[
222,
23,
1339
]
],
[
[
1133,
24,
283
],
[
283,
... | [
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Berotralstat"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Berotralstat
Granisetron may lead to a major life threatening interaction when taken with Sibutramine and Sibutramine may ca... |
DB00950 | DB13874 | 1,413 | 1,501 | [
"DDInter732",
"DDInter639"
] | Fexofenadine | Enasidenib | Fexofenadine is an over-the-counter second-generation antihistamine used in the treatment of various allergic symptoms. It is selective for the H<sub>1</sub> receptor, carries little-to-no activity at off-targets, and does not cross the blood-brain barrier - this is in contrast to previous first-generation antihistamin... | Enasidenib is an orally available treatment for the treatment of adult patients with relapsed or refractory acute myeloid leukemia (AML) with specific mutations in the isocitrate dehydrogenase 2 (IDH2) gene, which is a recurrent mutation detected in 12-20% of adult patients with AML [A20344, A20345]. Patients eligible ... | Moderate | 1 | [
[
[
1413,
24,
1501
]
],
[
[
1413,
24,
72
],
[
72,
24,
1501
]
],
[
[
1413,
24,
1339
],
[
1339,
64,
1501
]
],
[
[
1413,
24,
72
],
[
72,
... | [
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Enasidenib"
]
],
[
[
"Fexofenadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eltrombopag"
],
... | Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Eltrombopag and Eltrombopag may cause a moderate interaction that could exacerbate diseases when taken with Enasidenib
Fexofenadine may cause a moderate interaction that could exacerbate diseases when taken with Berotralstat an... |
DB01122 | DB01284 | 158 | 1,042 | [
"DDInter61",
"DDInter1782"
] | Ambenonium | Tetracosactide | Ambenonium is a cholinesterase inhibitor. It is used in the management of myasthenia gravis. | Tetracosactide (also known as Cosyntropin) is a synthetic peptide that is identical to the 24-amino acid segment (sequence: SYSMEHFRWGKPVGKKRRPVKVYP) at the N-terminal of adrenocorticotropic hormone. ACTH (1-24), a segment similar in all species, contains the biological activity that stimulates production of corticoste... | Moderate | 1 | [
[
[
158,
24,
1042
]
],
[
[
158,
24,
1011
],
[
1011,
64,
1042
]
],
[
[
158,
6,
10558
],
[
10558,
45,
61
],
[
61,
24,
1042
]
],
[
[
158,
... | [
[
[
"Ambenonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tetracosactide"
]
],
[
[
"Ambenonium",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fingolimod"
],
... | Ambenonium may cause a moderate interaction that could exacerbate diseases when taken with Fingolimod and Fingolimod may lead to a major life threatening interaction when taken with Tetracosactide
Ambenonium (Compound) binds BCHE (Gene) and BCHE (Gene) is bound by Edrophonium (Compound) and Edrophonium may cause a mode... |
DB00238 | DB00348 | 188 | 254 | [
"DDInter1285",
"DDInter1300"
] | Nevirapine | Nitisinone | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. | Moderate | 1 | [
[
[
188,
24,
254
]
],
[
[
188,
21,
29224
],
[
29224,
60,
254
]
],
[
[
188,
24,
392
],
[
392,
63,
254
]
],
[
[
188,
25,
1476
],
[
1476,
... | [
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nitisinone"
]
],
[
[
"Nevirapine",
"{u} (Compound) causes {v} (Side Effect)",
"Rash erythematous"
],
[
"Rash erythematous",
"{u} (Side... | Nevirapine (Compound) causes Rash erythematous (Side Effect) and Rash erythematous (Side Effect) is caused by Nitisinone (Compound)
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Lapatinib and Lapatinib may cause a moderate interaction that could exacerbate diseases when take... |
DB00570 | DB11817 | 147 | 1,259 | [
"DDInter1936",
"DDInter165"
] | Vinblastine | Baricitinib | Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) | Baricitinib is a Janus kinase (JAK) inhibitor. JAKs are tyrosine protein kinases that play an important role in pro-inflammatory signaling pathways. Overactive JAKs have been implicated in autoimmune disorders, such as rheumatoid arthritis. By inhibiting the actions of JAK1 and JAK2, baricitinib attenuates JAK-mediated... | Major | 2 | [
[
[
147,
25,
1259
]
],
[
[
147,
63,
1461
],
[
1461,
23,
1259
]
],
[
[
147,
24,
949
],
[
949,
24,
1259
]
],
[
[
147,
24,
1129
],
[
1129,
... | [
[
[
"Vinblastine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Baricitinib"
]
],
[
[
"Vinblastine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vitamin E"
],
[
"Vitamin ... | Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Vitamin E and Vitamin E may cause a minor interaction that can limit clinical effects when taken with Baricitinib
Vinblastine may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani tox... |
DB09074 | DB11853 | 1,362 | 230 | [
"DDInter1327",
"DDInter1577"
] | Olaparib | Relugolix | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2.[L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Ol... | Relugolix is a gonadotropin-releasing hormone (GnRH) receptor antagonist used in the treatment of several hormone-responsive conditions. It was first approved in Japan in 2019, under the brand name Relumina, for the symptomatic treatment of uterine fibroids, and more recently by the United States' FDA in 2020, under th... | Moderate | 1 | [
[
[
1362,
24,
230
]
],
[
[
1362,
64,
129
],
[
129,
23,
230
]
],
[
[
1362,
63,
1094
],
[
1094,
23,
230
]
],
[
[
1362,
24,
1456
],
[
1456,
... | [
[
[
"Olaparib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Relugolix"
]
],
[
[
"Olaparib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Enzalutamide"
],
[
"Enzalutamide"... | Olaparib may lead to a major life threatening interaction when taken with Enzalutamide and Enzalutamide may cause a minor interaction that can limit clinical effects when taken with Relugolix
Olaparib may cause a moderate interaction that could exacerbate diseases when taken with Metreleptin and Metreleptin may cause a... |
DB01250 | DB05260 | 712 | 1,329 | [
"DDInter1334",
"DDInter804"
] | Olsalazine | Gallium nitrate | Olsalazine is an aminosalicylate and a prodrug of [mesalamine] (5-aminosalicylic acid, 5-ASA). It was first developed for delivering mesalamine to the colon without the use of [sulfapyridine]. Olsalazine comprises two mesalamine molecules joined by an azo bridge, which is cleaved in the colon. Olsalazine is an anti-inf... | Gallium nitrate is a nitrate salt of , a heavy metal that has been used as a diagnostic agent. Gallium nitrate is reported to possess antiresorptive and hypocalcemic effects on bone. GANITE, a product of gallium nitrate previously used to treat cancer-related hypercalcemia, was discontinued from marketing in the US for... | Moderate | 1 | [
[
[
712,
24,
1329
]
],
[
[
712,
63,
1555
],
[
1555,
24,
1329
]
],
[
[
712,
24,
123
],
[
123,
24,
1329
]
],
[
[
712,
1,
50
],
[
50,
2... | [
[
[
"Olsalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Gallium nitrate"
]
],
[
[
"Olsalazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oxaliplatin"
],
... | Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Oxaliplatin and Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Gallium nitrate
Olsalazine may cause a moderate interaction that could exacerbate diseases when taken with Exenatide and ... |
DB00009 | DB01166 | 1,271 | 477 | [
"DDInter56",
"DDInter379"
] | Alteplase | Cilostazol | Alteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It cleaves plasminogen to form plasmin, an enzyme involved in the degradation of fibrin clots. In the absence of fibrin, the alteplase-mediated conversion of plasminogen is limited, thanks to the high affinity between alteplas... | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by inhibiting both prim... | Moderate | 1 | [
[
[
1271,
24,
477
]
],
[
[
1271,
23,
297
],
[
297,
62,
477
]
],
[
[
1271,
25,
126
],
[
126,
23,
477
]
],
[
[
1271,
24,
109
],
[
109,
... | [
[
[
"Alteplase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
]
],
[
[
"Alteplase",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Clove"
],
[
"Clov... | Alteplase may cause a minor interaction that can limit clinical effects when taken with Clove and Clove may cause a minor interaction that can limit clinical effects when taken with Cilostazol
Alteplase may lead to a major life threatening interaction when taken with Warfarin and Warfarin may cause a minor interaction ... |
DB01069 | DB11632 | 401 | 580 | [
"DDInter1533",
"DDInter1343"
] | Promethazine | Opicapone | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Opicapone is a potent, reversible, and peripherally-acting third-generation inhibitor of catechol-o-methyltransferase (COMT), an enzyme involved in the breakdown of various catecholamines including dopamine.[A36938, A203048] Many patients with Parkinson’s disease treated with levodopa plus a dopa decarboxylase (DDC) in... | Moderate | 1 | [
[
[
401,
24,
580
]
],
[
[
401,
63,
104
],
[
104,
24,
580
]
],
[
[
401,
24,
830
],
[
830,
24,
580
]
],
[
[
401,
25,
1311
],
[
1311,
2... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opicapone"
]
],
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Opicapone
Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Phenindamine a... |
DB08870 | DB11601 | 850 | 1,270 | [
"DDInter228",
"DDInter1889"
] | Brentuximab vedotin | Tuberculin purified protein derivative | Brentuximab vedotin, also known as Adcetris®, is an antibody-drug conjugate that combines an anti-CD30 antibody with the drug monomethyl auristatin E (MMAE). It is an anti-neoplastic agent used in the treatment of Hodgkin's lymphoma and systemic anaplastic large-cell lymphoma. Brentuximab vedotin was initially approved... | Tuberculin Purified Protein Derivative (PPD) is a sterile aqueous solution of a purified protein fraction for intradermal administration as an aid in the diagnosis of tuberculosis. The diagnostic test is commonly referred to as the Mantoux test which serves to minimize the risk of transmission of infection with *Mycoba... | Moderate | 1 | [
[
[
850,
24,
1270
]
],
[
[
850,
24,
350
],
[
350,
24,
1270
]
],
[
[
850,
63,
1531
],
[
1531,
24,
1270
]
],
[
[
850,
64,
1064
],
[
1064,
... | [
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tuberculin purified protein derivative"
]
],
[
[
"Brentuximab vedotin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken... | Brentuximab vedotin may cause a moderate interaction that could exacerbate diseases when taken with Carfilzomib and Carfilzomib may cause a moderate interaction that could exacerbate diseases when taken with Tuberculin purified protein derivative
Brentuximab vedotin may cause a moderate interaction that could exacerbat... |
DB00046 | DB00902 | 1,179 | 104 | [
"DDInter940",
"DDInter1168"
] | Insulin lispro | Methdilazine | Insulin lispro is a rapid-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Insulin is prescribed for the management of diabetes mellitus to mimic the activity of endogenously produced human insulin, a peptide hormone produced by beta cells of the pancreas that promote... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
1179,
24,
104
]
],
[
[
1179,
24,
820
],
[
820,
1,
104
]
],
[
[
1179,
24,
401
],
[
401,
63,
104
]
],
[
[
1179,
24,
417
],
[
417,
... | [
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Insulin lispro",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
... | Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Insulin lispro may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate intera... |
DB01610 | DB11760 | 248 | 119 | [
"DDInter1912",
"DDInter1742"
] | Valganciclovir | Talazoparib | Valganciclovir hydrochloride (Valcyte, manufactured by Roche) is an antiviral medication used to treat cytomegalovirus infections. As the L-valyl ester of ganciclovir, it is actually a prodrug for ganciclovir. After oral administration, it is rapidly converted to ganciclovir by intestinal and hepatic esterases. | Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair. Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 and by the EMA in June 2019. It was app... | Moderate | 1 | [
[
[
248,
24,
119
]
],
[
[
248,
63,
599
],
[
599,
24,
119
]
],
[
[
248,
24,
985
],
[
985,
24,
119
]
],
[
[
248,
24,
1619
],
[
1619,
6... | [
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Talazoparib"
]
],
[
[
"Valganciclovir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alemtuzumab"
]... | Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Alemtuzumab and Alemtuzumab may cause a moderate interaction that could exacerbate diseases when taken with Talazoparib
Valganciclovir may cause a moderate interaction that could exacerbate diseases when taken with Osimertini... |
DB00915 | DB01114 | 1,170 | 272 | [
"DDInter60",
"DDInter362"
] | Amantadine | Chlorpheniramine | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. | Moderate | 1 | [
[
[
1170,
24,
272
]
],
[
[
1170,
24,
849
],
[
849,
63,
272
]
],
[
[
1170,
63,
128
],
[
128,
24,
272
]
],
[
[
1170,
6,
10715
],
[
10715,
... | [
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Chlorpheniramine"
]
],
[
[
"Amantadine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Mepyramine"
],
... | Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Mepyramine and Mepyramine may cause a moderate interaction that could exacerbate diseases when taken with Chlorpheniramine
Amantadine may cause a moderate interaction that could exacerbate diseases when taken with Dexbrompheniram... |
DB00261 | DB06605 | 702 | 1,409 | [
"DDInter93",
"DDInter108"
] | Anagrelide | Apixaban | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FD... | Major | 2 | [
[
[
702,
25,
1409
]
],
[
[
702,
6,
7950
],
[
7950,
45,
1409
]
],
[
[
702,
21,
29666
],
[
29666,
60,
1409
]
],
[
[
702,
23,
539
],
[
539,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Apixaban"
]
],
[
[
"Anagrelide",
"{u} (Compound) binds {v} (Gene)",
"CYP1A2"
],
[
"CYP1A2",
"{u} (Gene) is bound by {v} (Compound)",
"Apixaban"... | Anagrelide (Compound) binds CYP1A2 (Gene) and CYP1A2 (Gene) is bound by Apixaban (Compound)
Anagrelide (Compound) causes Melaena (Side Effect) and Melaena (Side Effect) is caused by Apixaban (Compound)
Anagrelide may cause a minor interaction that can limit clinical effects when taken with Capsicum and Capsicum may cau... |
DB00902 | DB09293 | 104 | 116 | [
"DDInter1168",
"DDInter954"
] | Methdilazine | Iodide I-131 | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Iodide I-131 (as Sodium iodide I-131) is a radioisotopic drug used for the treatment and palliation of thyroid malignancy. Iodine-131 is notable for causing mutation and death in cells that it penetrates, which is due to its mode of beta decay. As a result of beta decay, approximately 10% of its energy and radiation do... | Moderate | 1 | [
[
[
104,
24,
116
]
],
[
[
104,
63,
701
],
[
701,
24,
116
]
],
[
[
104,
24,
516
],
[
516,
24,
116
]
],
[
[
104,
40,
820
],
[
820,
24,... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodide I-131"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clemastine"
],
... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Clemastine and Clemastine may cause a moderate interaction that could exacerbate diseases when taken with Iodide I-131
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Levocetirizine ... |
DB00782 | DB01619 | 1,123 | 830 | [
"DDInter1535",
"DDInter1441"
] | Propantheline | Phenindamine | A muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. | Phenindamine is an antihistamine. Phenindamine blocks the effects of the naturally occurring chemical histamine in your body. Antihistamines such as phenindamine appear to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine ... | Moderate | 1 | [
[
[
1123,
24,
830
]
],
[
[
1123,
24,
537
],
[
537,
40,
830
]
],
[
[
1123,
63,
1219
],
[
1219,
40,
830
]
],
[
[
1123,
63,
357
],
[
357,
... | [
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Phenindamine"
]
],
[
[
"Propantheline",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cyclizine"
],
... | Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Cyclizine and Cyclizine (Compound) resembles Phenindamine (Compound)
Propantheline may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine (Compound) resembles Phenindamine (Comp... |
DB00556 | DB11837 | 1,262 | 1,297 | [
"DDInter1429",
"DDInter1351"
] | Perflutren | Osilodrostat | Perflutren, a diagnostic drug that is intended to be used for contrast enhancement during the indicated echocardiographic procedures, is comprised of lipid-coated microspheres filled with octafluoropropane(OFP) gas. When exposed to ultrasound waves, the microspheres resonate and "echo" strong signals back to the ultras... | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Moderate | 1 | [
[
[
1262,
24,
1297
]
],
[
[
1262,
23,
112
],
[
112,
23,
1297
]
],
[
[
1262,
24,
401
],
[
401,
24,
1297
]
],
[
[
1262,
63,
1555
],
[
1555,
... | [
[
[
"Perflutren",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Osilodrostat"
]
],
[
[
"Perflutren",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[... | Perflutren may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Osilodrostat
Perflutren may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and ... |
DB04868 | DB12893 | 478 | 586 | [
"DDInter1293",
"DDInter1629"
] | Nilotinib | Sacituzumab govitecan | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Metastatic triple-negative breast cancer (mTNBC) is an aggressive form of breast cancer with limited treatment options involving cytotoxic chemotherapy agents. Targeted chemotherapy through the application of antibody-conjugated agents (ADCs) is a recent advance in cancer treatment. One such ADC is sacituzumab goviteca... | Major | 2 | [
[
[
478,
25,
586
]
],
[
[
478,
24,
270
],
[
270,
24,
586
]
],
[
[
478,
63,
58
],
[
58,
24,
586
]
],
[
[
478,
25,
384
],
[
384,
24,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Sacituzumab govitecan"
]
],
[
[
"Nilotinib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
],
[
"... | Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab and Ocrelizumab may cause a moderate interaction that could exacerbate diseases when taken with Sacituzumab govitecan
Nilotinib may cause a moderate interaction that could exacerbate diseases when taken with Alefacept ... |
DB01242 | DB01254 | 1,237 | 1,213 | [
"DDInter410",
"DDInter484"
] | Clomipramine | Dasatinib | Clomipramine, the 3-chloro analog of imipramine, is a dibenzazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, clomipramine does not affect mood or aro... | Dasatinib is an orally available multikinase inhibitor indicated for the treatment of Philadelphia chromosome (Ph)-positive leukemias.[A2224,L45171] Ph is a chromosomal abnormality found in patients with chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL), where the ABL tyrosine kinase and the break... | Moderate | 1 | [
[
[
1237,
24,
1213
]
],
[
[
1237,
6,
4973
],
[
4973,
45,
1213
]
],
[
[
1237,
21,
28882
],
[
28882,
60,
1213
]
],
[
[
1237,
62,
112
],
[
11... | [
[
[
"Clomipramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dasatinib"
]
],
[
[
"Clomipramine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)"... | Clomipramine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Dasatinib (Compound)
Clomipramine (Compound) causes Body temperature increased (Side Effect) and Body temperature increased (Side Effect) is caused by Dasatinib (Compound)
Clomipramine may cause a minor interaction that can limit clinical effects w... |
DB08871 | DB09054 | 36 | 384 | [
"DDInter666",
"DDInter905"
] | Eribulin | Idelalisib | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Idelalisib is a phosphoinositide 3-kinase inhibitor indicated in the treatment of chronic lymphocytic leukemia (CLL), relapsed follicular B-cell non-Hodgkin lymphoma (FL), and relapsed small lymphocytic lymphoma (SLL). For the treatment of relapsed CLL, it is currently indicated as a second-line agent in combination wi... | Moderate | 1 | [
[
[
36,
24,
384
]
],
[
[
36,
64,
318
],
[
318,
23,
384
]
],
[
[
36,
63,
479
],
[
479,
23,
384
]
],
[
[
36,
25,
1618
],
[
1618,
24,
... | [
[
[
"Eribulin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Idelalisib"
]
],
[
[
"Eribulin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Escitalopram"
],
[
"Escitalopram... | Eribulin may lead to a major life threatening interaction when taken with Escitalopram and Escitalopram may cause a minor interaction that can limit clinical effects when taken with Idelalisib
Eribulin may cause a moderate interaction that could exacerbate diseases when taken with Donepezil and Donepezil may cause a mi... |
DB00902 | DB09061 | 104 | 1,627 | [
"DDInter1168",
"DDInter284"
] | Methdilazine | Cannabidiol | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Cannabidiol, or CBD, is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical i... | Moderate | 1 | [
[
[
104,
24,
1627
]
],
[
[
104,
63,
1419
],
[
1419,
23,
1627
]
],
[
[
104,
63,
1594
],
[
1594,
24,
1627
]
],
[
[
104,
24,
516
],
[
516,
... | [
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cannabidiol"
]
],
[
[
"Methdilazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Imatinib"
],
[... | Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Imatinib and Imatinib may cause a minor interaction that can limit clinical effects when taken with Cannabidiol
Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylam... |
DB00095 | DB09312 | 66 | 967 | [
"DDInter623",
"DDInter106"
] | Efalizumab | Antithymocyte immunoglobulin (rabbit) | Humanized IgG1 kappa isotype monoclonal antibody that binds to human CD11a. Efalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. The FDA approved efalizumab in 2003. It wa... | Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin i... | Moderate | 1 | [
[
[
66,
24,
967
]
],
[
[
66,
23,
1193
],
[
1193,
62,
967
]
],
[
[
66,
24,
1683
],
[
1683,
24,
967
]
],
[
[
66,
24,
1531
],
[
1531,
6... | [
[
[
"Efalizumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Antilymphocyte immunoglobulin (horse)"
]
],
[
[
"Efalizumab",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Zi... | Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Antilymphocyte immunoglobulin (horse)
Efalizumab may cause a minor interaction that can limit clinical effects when taken with Zinc gluconate and Zinc gluconate may cause a minor interaction that can limit clinical effects when t... |
DB00264 | DB01222 | 88 | 617 | [
"DDInter1200",
"DDInter246"
] | Metoprolol | Budesonide | Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succi... | Budesonide is a glucocorticoid that is a mix of the 22R and 22S epimer used to treat inflammatory conditions of the lungs and intestines such as asthma, COPD, Crohn's disease, and ulcerative colitis.[A188529,A188532] Budesonide was granted FDA approval on 14 February 1994. It is also available in a combination product ... | Moderate | 1 | [
[
[
88,
24,
617
]
],
[
[
88,
24,
251
],
[
251,
1,
617
]
],
[
[
88,
18,
3877
],
[
3877,
57,
617
]
],
[
[
88,
21,
28719
],
[
28719,
60... | [
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Budesonide"
]
],
[
[
"Metoprolol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Betamethasone"
],
[... | Metoprolol may cause a moderate interaction that could exacerbate diseases when taken with Betamethasone and Betamethasone (Compound) resembles Budesonide (Compound)
Metoprolol (Compound) downregulates CAST (Gene) and CAST (Gene) is downregulated by Budesonide (Compound)
Metoprolol (Compound) causes Pain (Side Effect) ... |
DB00197 | DB01238 | 1,324 | 673 | [
"DDInter1881",
"DDInter118"
] | Troglitazone | Aripiprazole | Troglitazone was withdrawn in 2000 due to risk of hepatotoxicity. It was superseded by [pioglitazone] and [rosiglitazone]. | Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's. It is also indicated as an injection for agitation associated with schizophrenia or bipolar mania. Aripiprazole exerts its effects thr... | Moderate | 1 | [
[
[
1324,
24,
673
]
],
[
[
1324,
24,
851
],
[
851,
1,
673
]
],
[
[
1324,
24,
1424
],
[
1424,
24,
673
]
],
[
[
1324,
24,
761
],
[
761,
... | [
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Aripiprazole"
]
],
[
[
"Troglitazone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nefazodone"
],
... | Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Nefazodone and Nefazodone (Compound) resembles Aripiprazole (Compound)
Troglitazone may cause a moderate interaction that could exacerbate diseases when taken with Quinine and Quinine may cause a moderate interaction that could... |
DB00889 | DB09068 | 1,133 | 1,427 | [
"DDInter840",
"DDInter1948"
] | Granisetron | Vortioxetine | A serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients. | Vortioxetine is an antidepressant medication indicated for the treatment of major depressive disorder (MDD). It is classified as a serotonin modulator and stimulator (SMS) as it has a multimodal mechanism of action towards the serotonin neurotransmitter system whereby it simultaneously modulates one or more serotonin r... | Major | 2 | [
[
[
1133,
25,
1427
]
],
[
[
1133,
24,
477
],
[
477,
24,
1427
]
],
[
[
1133,
24,
1017
],
[
1017,
63,
1427
]
],
[
[
1133,
63,
1101
],
[
1101... | [
[
[
"Granisetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vortioxetine"
]
],
[
[
"Granisetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cilostazol"
],
[
"Cilost... | Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Cilostazol and Cilostazol may cause a moderate interaction that could exacerbate diseases when taken with Vortioxetine
Granisetron may cause a moderate interaction that could exacerbate diseases when taken with Lorlatinib and Lo... |
DB00041 | DB00425 | 1,648 | 558 | [
"DDInter38",
"DDInter1970"
] | Aldesleukin | Zolpidem | Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This... | Zolpidem, also known as _Ambien_, is a hypnotic drug that was initially approved by the FDA in 1992 [FDA label]. Zolpidem improves sleep in patients with insomnia. It is aimed for use in patients with difficulties initiating sleep. This drug decreases the time to fall asleep (sleep latency), increases the duration of s... | Moderate | 1 | [
[
[
1648,
24,
558
]
],
[
[
1648,
24,
407
],
[
407,
63,
558
]
],
[
[
1648,
24,
1594
],
[
1594,
24,
558
]
],
[
[
1648,
25,
770
],
[
770,
... | [
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Zolpidem"
]
],
[
[
"Aldesleukin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Opium"
],
[
"... | Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Opium and Opium may cause a moderate interaction that could exacerbate diseases when taken with Zolpidem
Aldesleukin may cause a moderate interaction that could exacerbate diseases when taken with Doxylamine and Doxylamine may c... |
DB00261 | DB00445 | 702 | 322 | [
"DDInter93",
"DDInter655"
] | Anagrelide | Epirubicin | Anagrelide is a platelet-reducing agent used to lower dangerously elevated platelet levels (i.e. to treat thrombocythemia) in patients with myeloproliferative neoplasms. It is an oral imidazoquinazoline that was first approved for use in the US in 1997. It appears to carry a better response rate than other thrombocythe... | An anthracycline which is the 4'-epi-isomer of doxorubicin. The compound exerts its antitumor effects by interference with the synthesis and function of DNA. | Major | 2 | [
[
[
702,
25,
322
]
],
[
[
702,
5,
11555
],
[
11555,
44,
322
]
],
[
[
702,
7,
2507
],
[
2507,
46,
322
]
],
[
[
702,
18,
7933
],
[
7933,
... | [
[
[
"Anagrelide",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Epirubicin"
]
],
[
[
"Anagrelide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease) is treated b... | Anagrelide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Epirubicin (Compound)
Anagrelide (Compound) upregulates NR1H2 (Gene) and NR1H2 (Gene) is upregulated by Epirubicin (Compound)
Anagrelide (Compound) downregulates DDX42 (Gene) and DDX42 (Gene) is downregulated by Epi... |
DB11095 | DB11689 | 235 | 321 | [
"DDInter505",
"DDInter1659"
] | Desirudin | Selumetinib | Desirudin is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three dis... | Activation of the Raf-MEK-ERK signalling pathway is known to be implemented in several types of malignancies; thus, mitogen-activated protein kinase kinase (MEK) inhibitors such as selumetinib are important tools that can target the problematic overactivity of this pathway. Results from clinical trials investigating ea... | Moderate | 1 | [
[
[
235,
24,
321
]
],
[
[
235,
24,
298
],
[
298,
24,
321
]
],
[
[
235,
64,
291
],
[
291,
24,
321
]
],
[
[
235,
25,
1421
],
[
1421,
6... | [
[
[
"Desirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Selumetinib"
]
],
[
[
"Desirudin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Protein C"
],
[
... | Desirudin may cause a moderate interaction that could exacerbate diseases when taken with Protein C and Protein C may cause a moderate interaction that could exacerbate diseases when taken with Selumetinib
Desirudin may lead to a major life threatening interaction when taken with Argatroban and Argatroban may cause a m... |
DB00023 | DB00814 | 305 | 1,171 | [
"DDInter127",
"DDInter1143"
] | Asparaginase Escherichia coli | Meloxicam | Asparaginase derived from _Escherichia coli_ (L-asparagine amidohydrolase, EC 3.5.1.1) is an enzyme responsible for the metabolism of L-asparagine, by catalyzing L-asparagine into L-aspartic acid and ammonia. It also facilitates the production of oxaloacetate which is needed for general cellular metabolism. Asparaginas... | Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve various types of pain, including pain caused by musculoskeletal conditions, osteoarthritis, and rheumatoid arthritis. With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is ... | Moderate | 1 | [
[
[
305,
24,
1171
]
],
[
[
305,
24,
1027
],
[
1027,
40,
1171
]
],
[
[
305,
24,
936
],
[
936,
63,
1171
]
],
[
[
305,
24,
912
],
[
912,
... | [
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Meloxicam"
]
],
[
[
"Asparaginase Escherichia coli",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}... | Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Piroxicam and Piroxicam (Compound) resembles Meloxicam (Compound)
Asparaginase Escherichia coli may cause a moderate interaction that could exacerbate diseases when taken with Cangrelor and Cangrelor may cause ... |
DB00461 | DB00959 | 598 | 1,486 | [
"DDInter1254",
"DDInter1191"
] | Nabumetone | Methylprednisolone | Nabumetone was originally developed as a non-acidic non-steroidal anti-inflammatory drug (NSAID).[label] It was thought to avoid trapping of the drug in the stomach by making it unable to dissociate into ions which was believed to reduce GI toxicity by limiting local action. While slightly reduced, possibly due to a de... | Methylprednisolone is a [prednisolone] derivative glucocorticoid with higher potency than [prednisone]. It was first described in the literature in the late 1950s.[A188811,A188814] Methylprednisolone was granted FDA approval on 24 October 1957. In the outbreak of COVID-19, low dose methylprednisolone-based therapy was ... | Moderate | 1 | [
[
[
598,
24,
1486
]
],
[
[
598,
24,
175
],
[
175,
40,
1486
]
],
[
[
598,
24,
167
],
[
167,
1,
1486
]
],
[
[
598,
63,
251
],
[
251,
1... | [
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methylprednisolone"
]
],
[
[
"Nabumetone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Triamcinolone"
... | Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Triamcinolone and Triamcinolone (Compound) resembles Methylprednisolone (Compound)
Nabumetone may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone (Compound) resembles ... |
DB00404 | DB11186 | 523 | 1,609 | [
"DDInter54",
"DDInter1427"
] | Alprazolam | Pentoxyverine | Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders.[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole.[L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down ... | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant , and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists . Pentoxyverine acts on sigma... | Moderate | 1 | [
[
[
523,
24,
1609
]
],
[
[
523,
24,
104
],
[
104,
24,
1609
]
],
[
[
523,
63,
999
],
[
999,
24,
1609
]
],
[
[
523,
1,
902
],
[
902,
2... | [
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentoxyverine"
]
],
[
[
"Alprazolam",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
],
... | Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine may cause a moderate interaction that could exacerbate diseases when taken with Pentoxyverine
Alprazolam may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazi... |
DB00791 | DB11003 | 132 | 748 | [
"DDInter1902",
"DDInter100"
] | Uracil mustard | Anthrax vaccine | Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage. | Anthrax vaccine is a vaccine used for the pre- or post-exposure prophylaxis of disease in those at high risk of, suspected or confirmed exposure to *Bacillus anthracis*. It is subcutaneously or intramuscularly administered. It is derived from cell-free filtrates of microaerophilic cultures of an avirulent, nonencapsula... | Moderate | 1 | [
[
[
132,
24,
748
]
],
[
[
132,
25,
676
],
[
676,
63,
748
]
],
[
[
132,
24,
1683
],
[
1683,
24,
748
]
],
[
[
132,
1,
970
],
[
970,
24... | [
[
[
"Uracil mustard",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Anthrax vaccine"
]
],
[
[
"Uracil mustard",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Upadacitinib"
],
[
... | Uracil mustard may lead to a major life threatening interaction when taken with Upadacitinib and Upadacitinib may cause a moderate interaction that could exacerbate diseases when taken with Anthrax vaccine
Uracil mustard may cause a moderate interaction that could exacerbate diseases when taken with Ustekinumab and Ust... |
DB00550 | DB01136 | 99 | 772 | [
"DDInter1541",
"DDInter305"
] | Propylthiouracil | Carvedilol | A thiourea antithyroid agent. Propythiouracil inhibits the synthesis of thyroxine and inhibits the peripheral conversion of throxine to tri-iodothyronine. It is used in the treatment of hyperthyroidism. (From Martindale, The Extra Pharmacopeoia, 30th ed, p534) | Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.[L7889,L7892] It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.[L7889,L7892] The dual action of carvedilol is a... | Moderate | 1 | [
[
[
99,
24,
772
]
],
[
[
99,
18,
2183
],
[
2183,
57,
772
]
],
[
[
99,
21,
28722
],
[
28722,
60,
772
]
],
[
[
99,
63,
542
],
[
542,
2... | [
[
[
"Propylthiouracil",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carvedilol"
]
],
[
[
"Propylthiouracil",
"{u} (Compound) downregulates {v} (Gene)",
"CDC20"
],
[
"CDC20",
"{u} (Gene) is downreg... | Propylthiouracil (Compound) downregulates CDC20 (Gene) and CDC20 (Gene) is downregulated by Carvedilol (Compound)
Propylthiouracil (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Carvedilol (Compound)
Propylthiouracil may cause a moderate interaction that could exacerbate diseases when take... |
DB00331 | DB08886 | 1,645 | 637 | [
"DDInter1164",
"DDInter126"
] | Metformin | Asparaginase Erwinia chrysanthemi | Metformin is a biguanide antihyperglycemic agent and first-line pharmacotherapy used in the management of type II diabetes.[L12207,A176173] Metformin is considered an antihyperglycemic drug because it lowers blood glucose concentrations in type II diabetes without causing hypoglycemia. It is commonly described as an "i... | Asparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. It works by depleting the stores of an important amino acid called asparagine, which is involved in DNA synthesis and cell survival of malignant cells, leading to cell death. L-aspar... | Moderate | 1 | [
[
[
1645,
24,
637
]
],
[
[
1645,
24,
167
],
[
167,
24,
637
]
],
[
[
1645,
62,
1647
],
[
1647,
24,
637
]
],
[
[
1645,
63,
245
],
[
245,
... | [
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Asparaginase Erwinia chrysanthemi"
]
],
[
[
"Metformin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Hydroc... | Metformin may cause a moderate interaction that could exacerbate diseases when taken with Hydrocortisone and Hydrocortisone may cause a moderate interaction that could exacerbate diseases when taken with Asparaginase Erwinia chrysanthemi
Metformin may cause a minor interaction that can limit clinical effects when taken... |
DB00777 | DB09045 | 146 | 52 | [
"DDInter1537",
"DDInter607"
] | Propiomazine | Dulaglutide | Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Struct... | Dulaglutide, marketed by Eli Lilly as Trulicity, is a once-weekly subcutaneous glucagon-like peptide-1 (GLP-1) receptor agonist designed using recombinant DNA technology; it has been approved as an adjunct therapy to diet and exercise in the management of 2 diabetes (T2DM). Dulaglutide was initially approved by the FDA... | Moderate | 1 | [
[
[
146,
24,
52
]
],
[
[
146,
24,
170
],
[
170,
23,
52
]
],
[
[
146,
63,
73
],
[
73,
24,
52
]
],
[
[
146,
40,
508
],
[
508,
24,
... | [
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dulaglutide"
]
],
[
[
"Propiomazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sitagliptin"
],
... | Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Sitagliptin and Sitagliptin may cause a minor interaction that can limit clinical effects when taken with Dulaglutide
Propiomazine may cause a moderate interaction that could exacerbate diseases when taken with Phentermine and ... |
DB00549 | DB00641 | 522 | 467 | [
"DDInter1955",
"DDInter1675"
] | Zafirlukast | Simvastatin | Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the maintenance treatment of asthma, often used in conjunction with an inhaled steroid and/or long-acting bronchodilator. It is available as a tablet and is usually dosed twice daily. Another leukotriene receptor antagonist is montelukast (Singulair), wh... | Simvastatin, also known as the brand name product Zocor, is a lipid-lowering drug derived synthetically from a fermentation product of _Aspergillus terreus_. It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endog... | Moderate | 1 | [
[
[
522,
24,
467
]
],
[
[
522,
6,
8374
],
[
8374,
45,
467
]
],
[
[
522,
21,
28810
],
[
28810,
60,
467
]
],
[
[
522,
24,
279
],
[
279,
... | [
[
[
"Zafirlukast",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Simvastatin"
]
],
[
[
"Zafirlukast",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound... | Zafirlukast (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Simvastatin (Compound)
Zafirlukast (Compound) causes Gastrointestinal pain (Side Effect) and Gastrointestinal pain (Side Effect) is caused by Simvastatin (Compound)
Zafirlukast may cause a moderate interaction that could exacerbate diseases when t... |
DB01240 | DB11827 | 885 | 433 | [
"DDInter657",
"DDInter669"
] | Epoprostenol | Ertugliflozin | A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension. | Ertugliflozin is a sodium-dependent glucose cotransporter-2 (SGLT2) inhibitor used to treat type II diabetes mellitus. It works to block glucose reabsorption from the glomerulus. Ertugliflozin was first approved by the FDA in December 2017.[A261951, L1132] It was also approved by the European Commission in March 2018. | Moderate | 1 | [
[
[
885,
24,
433
]
],
[
[
885,
63,
1020
],
[
1020,
24,
433
]
],
[
[
885,
24,
762
],
[
762,
24,
433
]
],
[
[
885,
40,
1061
],
[
1061,
... | [
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ertugliflozin"
]
],
[
[
"Epoprostenol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clonidine"
],
... | Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Clonidine and Clonidine may cause a moderate interaction that could exacerbate diseases when taken with Ertugliflozin
Epoprostenol may cause a moderate interaction that could exacerbate diseases when taken with Bepridil and Bep... |
DB00460 | DB00902 | 612 | 104 | [
"DDInter1929",
"DDInter1168"
] | Verteporfin | Methdilazine | Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative. It is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when stimulated by nonthermal red light with a wavelength of 693 n... | Methdilazine is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus. | Moderate | 1 | [
[
[
612,
24,
104
]
],
[
[
612,
24,
820
],
[
820,
1,
104
]
],
[
[
612,
24,
401
],
[
401,
63,
104
]
],
[
[
612,
24,
274
],
[
274,
24,
... | [
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Methdilazine"
]
],
[
[
"Verteporfin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
],
... | Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine and Alimemazine (Compound) resembles Methdilazine (Compound)
Verteporfin may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction ... |
DB00405 | DB00915 | 128 | 1,170 | [
"DDInter517",
"DDInter60"
] | Dexbrompheniramine | Amantadine | Dexbrompheniramine maleate is an antihistamine agent that is used for the treatment of allergic conditions, such as hay fever or urticaria. | An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesi... | Moderate | 1 | [
[
[
128,
24,
1170
]
],
[
[
128,
24,
1219
],
[
1219,
24,
1170
]
],
[
[
128,
24,
1532
],
[
1532,
63,
1170
]
],
[
[
128,
63,
999
],
[
999,
... | [
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Amantadine"
]
],
[
[
"Dexbrompheniramine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Azatadine"
... | Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Azatadine and Azatadine may cause a moderate interaction that could exacerbate diseases when taken with Amantadine
Dexbrompheniramine may cause a moderate interaction that could exacerbate diseases when taken with Ifosfam... |
DB00501 | DB00682 | 752 | 126 | [
"DDInter380",
"DDInter1951"
] | Cimetidine | Warfarin | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Warfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America. Warfarin has several properties that should be not... | Moderate | 1 | [
[
[
752,
24,
126
]
],
[
[
752,
64,
362
],
[
362,
24,
126
]
],
[
[
752,
63,
847
],
[
847,
40,
126
]
],
[
[
752,
6,
3486
],
[
3486,
45... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Warfarin"
]
],
[
[
"Cimetidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Phenytoin"
],
[
"Phenytoin",
... | Cimetidine may lead to a major life threatening interaction when taken with Phenytoin and Phenytoin may cause a moderate interaction that could exacerbate diseases when taken with Warfarin
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Atomoxetine and Atomoxetine (Compound) r... |
DB00994 | DB01333 | 361 | 207 | [
"DDInter1277",
"DDInter328"
] | Neomycin | Cefradine | Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of _Streptomyces fradiae_. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as [framycetin], is the most active component of the complex and neomycin C is the isomer o... | A semi-synthetic cephalosporin antibiotic. | Moderate | 1 | [
[
[
361,
24,
207
]
],
[
[
361,
24,
315
],
[
315,
40,
207
]
],
[
[
361,
63,
778
],
[
778,
1,
207
]
],
[
[
361,
24,
1227
],
[
1227,
1,... | [
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefradine"
]
],
[
[
"Neomycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cefprozil"
],
[
"C... | Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefprozil and Cefprozil (Compound) resembles Cefradine (Compound)
Neomycin may cause a moderate interaction that could exacerbate diseases when taken with Cefixime and Cefixime (Compound) resembles Cefradine (Compound)
Neomycin may... |
DB04868 | DB06288 | 478 | 607 | [
"DDInter1293",
"DDInter77"
] | Nilotinib | Amisulpride | Nilotinib, also known as AMN107, is a tyrosine kinase inhibitor under investigation as a possible treatment for chronic myelogenous leukemia (CML). A Phase I clinical trial in 2006 showed that this drug was relatively safe and offered significant therapeutic benefits in cases of CML which were found to be resistant to ... | Amisulpride is a benzamide derivative and a dopamine receptor antagonist that selectively works on dopamine D2 and D3 receptors. As an antipsychotic agent, amisulpride alleviates both positive and negative symptoms of schizophrenia, and it exhibits antidepressant properties in patients with psychiatric disorders, dysth... | Major | 2 | [
[
[
478,
25,
607
]
],
[
[
478,
21,
29232
],
[
29232,
60,
607
]
],
[
[
478,
62,
112
],
[
112,
23,
607
]
],
[
[
478,
63,
1559
],
[
1559,
... | [
[
[
"Nilotinib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Amisulpride"
]
],
[
[
"Nilotinib",
"{u} (Compound) causes {v} (Side Effect)",
"Urticaria"
],
[
"Urticaria",
"{u} (Side Effect) is caused by {v} (Compo... | Nilotinib (Compound) causes Urticaria (Side Effect) and Urticaria (Side Effect) is caused by Amisulpride (Compound)
Nilotinib may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Amisul... |
DB00163 | DB08879 | 1,461 | 632 | [
"DDInter1943",
"DDInter173"
] | Vitamin E | Belimumab | In 1922, vitamin E was demonstrated to be an essential nutrient. Vitamin E is a term used to describe 8 different fat soluble tocopherols and tocotrienols, alpha-tocopherol being the most biologically active. Vitamin E acts as an antioxidant, protecting cell membranes from oxidative damage. The antioxidant effects are ... | Belimumab is a fully human recombinant IgG1λ monoclonal antibody that inhibits soluble human B lymphocyte stimulator protein (BLyS, also referred to as BAFF and TNFSF13B), a B cell survival factor. BLyS levels are often elevated in immunodeficient and autoimmune disorders, such as systemic lupus erythematosus (SLE).[A2... | Minor | 0 | [
[
[
1461,
23,
632
]
],
[
[
1461,
62,
1184
],
[
1184,
24,
632
]
],
[
[
1461,
23,
1683
],
[
1683,
24,
632
]
],
[
[
1461,
23,
270
],
[
270,
... | [
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Belimumab"
]
],
[
[
"Vitamin E",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Anakinra"
],
[
"Anak... | Vitamin E may cause a minor interaction that can limit clinical effects when taken with Anakinra and Anakinra may cause a moderate interaction that could exacerbate diseases when taken with Belimumab
Vitamin E may cause a minor interaction that can limit clinical effects when taken with Ustekinumab and Ustekinumab may ... |
DB06448 | DB09065 | 171 | 760 | [
"DDInter1087",
"DDInter424"
] | Lonafarnib | Cobicistat | Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant disorder estimated to affect approximately one in 20 million individuals resulting in adverse symptoms associated with premature ageing: skeletal dysplasia, joint contractures, atherosclerosis, myocardial fibrosis/dysfunction, scleroderma-like cut... | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Major | 2 | [
[
[
171,
25,
760
]
],
[
[
171,
63,
1101
],
[
1101,
23,
760
]
],
[
[
171,
63,
1041
],
[
1041,
24,
760
]
],
[
[
171,
64,
723
],
[
723,
... | [
[
[
"Lonafarnib",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobicistat"
]
],
[
[
"Lonafarnib",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
[
"Bexarotene... | Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Cobicistat
Lonafarnib may cause a moderate interaction that could exacerbate diseases when taken with Paricalcitol and Parica... |
DB00238 | DB05239 | 188 | 866 | [
"DDInter1285",
"DDInter425"
] | Nevirapine | Cobimetinib | A potent, non-nucleoside reverse transcriptase inhibitor (NNRTI) used in combination with nucleoside analogues for treatment of Human Immunodeficiency Virus Type 1 (HIV-1) infection and AIDS. Structurally, nevirapine belongs to the dipyridodiazepinone chemical class. | Cobimetinib is an orally active, potent and highly selective small molecule inhibiting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), and central components of the RAS/RAF/MEK/ERK signal transduction pathway. It has been approved in Switzerland and the US, in combination with vemurafenib for the treatment ... | Major | 2 | [
[
[
188,
25,
866
]
],
[
[
188,
24,
214
],
[
214,
63,
866
]
],
[
[
188,
24,
888
],
[
888,
24,
866
]
],
[
[
188,
25,
484
],
[
484,
63,... | [
[
[
"Nevirapine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Cobimetinib"
]
],
[
[
"Nevirapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
],
[
"Fostama... | Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib and Fostamatinib may cause a moderate interaction that could exacerbate diseases when taken with Cobimetinib
Nevirapine may cause a moderate interaction that could exacerbate diseases when taken with Tamoxifen and Ta... |
DB09065 | DB12941 | 760 | 466 | [
"DDInter424",
"DDInter481"
] | Cobicistat | Darolutamide | Cobicistat, marketed under the name Tybost (formerly GS-9350), indicated for treating infection with human immunodeficiency virus (HIV). Although it does not have any anti-HIV activity, cobicistat acts as a pharmacokinetic enhancer by inhibiting cytochrome P450 3A isoforms (CYP3A) and therefore increases the systemic e... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
760,
24,
466
]
],
[
[
760,
63,
1622
],
[
1622,
23,
466
]
],
[
[
760,
64,
1623
],
[
1623,
23,
466
]
],
[
[
760,
62,
1374
],
[
1374,
... | [
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Cobicistat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Voriconazole"
],
... | Cobicistat may cause a moderate interaction that could exacerbate diseases when taken with Voriconazole and Voriconazole may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Cobicistat may lead to a major life threatening interaction when taken with Isavuconazonium and Isavuconazon... |
DB00938 | DB01067 | 455 | 959 | [
"DDInter1635",
"DDInter826"
] | Salmeterol | Glipizide | Salmeterol is a long-acting beta-2 adrenergic receptor agonist drug that is currently prescribed for the treatment of asthma and chronic obstructive pulmonary disease COPD.[L11545,L11548,L11551,L11554,L11557] It has a longer duration of action than the short-acting beta-2 adrenergic receptor agonist, [salbutamol]. Salm... | Glipizide is an oral hypoglycemic agent in the second-generation sulfonylurea drug class that is used to control blood sugar levels in patients with type 2 diabetes mellitus. It was first introduced in 1984 and is available in various countries including Canada and the U.S. According to the 2018 Clinical Practice Guide... | Moderate | 1 | [
[
[
455,
24,
959
]
],
[
[
455,
63,
245
],
[
245,
40,
959
]
],
[
[
455,
24,
1411
],
[
1411,
1,
959
]
],
[
[
455,
6,
8374
],
[
8374,
4... | [
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glipizide"
]
],
[
[
"Salmeterol",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Glimepiride"
],
[
... | Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Glimepiride and Glimepiride (Compound) resembles Glipizide (Compound)
Salmeterol may cause a moderate interaction that could exacerbate diseases when taken with Tolbutamide and Tolbutamide (Compound) resembles Glipizide (Compound... |
DB00472 | DB01246 | 758 | 820 | [
"DDInter758",
"DDInter45"
] | Fluoxetine | Alimemazine | Fluoxetine is a 2nd generation antidepressant categorized as a selective serotonin reuptake inhibitor (SSRI). It gained FDA approval in 1987 and although it was initially intended for the treatment of depression, today it is commonly prescribed to manage depression in addition to various other pathologies. | A phenothiazine derivative that is used as an antipruritic. | Moderate | 1 | [
[
[
758,
24,
820
]
],
[
[
758,
40,
358
],
[
358,
24,
820
]
],
[
[
758,
24,
104
],
[
104,
40,
820
]
],
[
[
758,
24,
401
],
[
401,
24,... | [
[
[
"Fluoxetine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Alimemazine"
]
],
[
[
"Fluoxetine",
"{u} (Compound) resembles {v} (Compound)",
"Orphenadrine"
],
[
"Orphenadrine",
"{u} may cause a mo... | Fluoxetine (Compound) resembles Orphenadrine (Compound) and Orphenadrine may cause a moderate interaction that could exacerbate diseases when taken with Alimemazine
Fluoxetine may cause a moderate interaction that could exacerbate diseases when taken with Methdilazine and Methdilazine (Compound) resembles Alimemazine (... |
DB00444 | DB00515 | 63 | 589 | [
"DDInter1765",
"DDInter387"
] | Teniposide | Cisplatin | Teniposide is a semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Teniposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent cells ... | Cisplatin, cisplatinum or cis-diamminedichloroplatinum(II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also incl... | Moderate | 1 | [
[
[
63,
24,
589
]
],
[
[
63,
5,
11555
],
[
11555,
44,
589
]
],
[
[
63,
7,
5566
],
[
5566,
45,
589
]
],
[
[
63,
6,
17404
],
[
17404,
... | [
[
[
"Teniposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
]
],
[
[
"Teniposide",
"{u} (Compound) treats {v} (Disease)",
"hematologic cancer"
],
[
"hematologic cancer",
"{u} (Disease... | Teniposide (Compound) treats hematologic cancer (Disease) and hematologic cancer (Disease) is treated by Cisplatin (Compound)
Teniposide (Compound) upregulates SLC31A2 (Gene) and SLC31A2 (Gene) is bound by Cisplatin (Compound)
Teniposide (Compound) binds ABCG2 (Gene) and ABCG2 (Gene) is bound by Cisplatin (Compound)
Te... |
DB00760 | DB09472 | 1,584 | 1,383 | [
"DDInter1157",
"DDInter1693"
] | Meropenem | Sodium sulfate | Meropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. Meropenem exerts its action by penetrating bacterial cells readily and interfering with the synthesis of vital cell wall components, which leads to cell death. In August 2017, a combination antibacterial ... | Sodium Sulfate Anhydrous is the anhydrous, sodium salt form of sulfuric acid. Sodium sulfate anhydrous disassociates in water to provide sodium ions and sulfate ions. Sodium ion is the principal cation of the extracellular fluid and plays a large part in the therapy of fluid and electrolyte disturbances. Sodium sulfate... | Moderate | 1 | [
[
[
1584,
24,
1383
]
],
[
[
1584,
25,
593
],
[
593,
24,
1383
]
],
[
[
1584,
63,
1503
],
[
1503,
24,
1383
]
],
[
[
1584,
24,
927
],
[
927,
... | [
[
[
"Meropenem",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Sodium sulfate"
]
],
[
[
"Meropenem",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bupropion"
],
[
"Bupropion... | Meropenem may lead to a major life threatening interaction when taken with Bupropion and Bupropion may cause a moderate interaction that could exacerbate diseases when taken with Sodium sulfate
Meropenem may cause a moderate interaction that could exacerbate diseases when taken with Lindane and Lindane may cause a mode... |
DB00705 | DB01129 | 441 | 379 | [
"DDInter496",
"DDInter1559"
] | Delavirdine | Rabeprazole | A potent, non-nucleoside reverse transcriptase inhibitor with activity specific for HIV-1. | Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion. | Moderate | 1 | [
[
[
441,
24,
379
]
],
[
[
441,
63,
1215
],
[
1215,
40,
379
]
],
[
[
441,
24,
660
],
[
660,
1,
379
]
],
[
[
441,
63,
837
],
[
837,
1,... | [
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Rabeprazole"
]
],
[
[
"Delavirdine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Lansoprazole"
],
... | Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Lansoprazole and Lansoprazole (Compound) resembles Rabeprazole (Compound)
Delavirdine may cause a moderate interaction that could exacerbate diseases when taken with Esomeprazole and Esomeprazole (Compound) resembles Rabeprazole... |
DB10989 | DB11988 | 496 | 270 | [
"DDInter858",
"DDInter1321"
] | Hepatitis A Vaccine | Ocrelizumab | Hepatitis A viral infection can lead to significant morbidity and mortality, with signs and symptoms that include anorexia, nausea, vomiting, and liver failure. Known by several trade names, such as Havrix and Twinrix, the Hepatitis A vaccine has been formulated for immunization against hepatitis A virus (HAV) infectio... | Ocrelizumab is a CD20-directed cytolytic antibody indicated for the treatment of patients with primary progressive or relapsing forms of multiple sclerosis (MS). It is a second-generation recombinant humanized monoclonal IgG1 antibody that selectively targets B-cells that express the CD20 antigen. Compared to non-human... | Moderate | 1 | [
[
[
496,
24,
270
]
],
[
[
496,
63,
134
],
[
134,
24,
270
]
],
[
[
496,
24,
1019
],
[
1019,
24,
270
]
],
[
[
496,
24,
398
],
[
398,
6... | [
[
[
"Hepatitis A Vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Ocrelizumab"
]
],
[
[
"Hepatitis A Vaccine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vinorelb... | Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine and Vinorelbine may cause a moderate interaction that could exacerbate diseases when taken with Ocrelizumab
Hepatitis A Vaccine may cause a moderate interaction that could exacerbate diseases when taken with ... |
DB11186 | DB11915 | 1,609 | 1,293 | [
"DDInter1427",
"DDInter1909"
] | Pentoxyverine | Valbenazine | Pentoxyverine, also referred to as carbetapentane, is a non-opioid central acting antitussive with antimuscarinic, anticonvulsant, and local anesthetic properties. It is an active ingredient in over-the-counter cough suppressants in combination with guaifenesin and H1-receptor antagonists. Pentoxyverine acts on sigma-1... | Valbenazine is a modified metabolite of [tetrabenazine], and it is currently being approved for the treatment of various movement disorders, particularly tardive dyskinesia and chorea associated with Huntington's disease.[L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine recept... | Moderate | 1 | [
[
[
1609,
24,
1293
]
],
[
[
1609,
63,
401
],
[
401,
24,
1293
]
],
[
[
1609,
64,
1053
],
[
1053,
25,
1293
]
],
[
[
1609,
63,
401
],
[
401,
... | [
[
[
"Pentoxyverine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Valbenazine"
]
],
[
[
"Pentoxyverine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Promethazine"
],... | Pentoxyverine may cause a moderate interaction that could exacerbate diseases when taken with Promethazine and Promethazine may cause a moderate interaction that could exacerbate diseases when taken with Valbenazine
Pentoxyverine may lead to a major life threatening interaction when taken with Procarbazine and Procarba... |
DB00019 | DB01229 | 1,257 | 973 | [
"DDInter1405",
"DDInter1377"
] | Pegfilgrastim | Paclitaxel | Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor (G-CSF) analogue, [filgrastim]. The drug is approved for use to decrease the incidence of infection, as manifested by febrile neutropenia, in susceptible patients with with non-myeloid cancer receiving myelosuppressive anti... | Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others. Used as a treatment for various cancers, paclitaxel is a mitotic inhibitor that was first isolated in 1971 from the bark of the Pacific yew tree which contains endophytic fungi that synthesize paclitaxel. It is available as an intr... | Moderate | 1 | [
[
[
1257,
24,
973
]
],
[
[
1257,
24,
310
],
[
310,
63,
973
]
],
[
[
1257,
24,
134
],
[
134,
24,
973
]
],
[
[
1257,
63,
491
],
[
491,
... | [
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Paclitaxel"
]
],
[
[
"Pegfilgrastim",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cabazitaxel"
],
... | Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Cabazitaxel and Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Paclitaxel
Pegfilgrastim may cause a moderate interaction that could exacerbate diseases when taken with Vinorelbine a... |
DB01211 | DB01232 | 609 | 1,327 | [
"DDInter393",
"DDInter1640"
] | Clarithromycin | Saquinavir | Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarith... | Saquinavir is an HIV-1 protease inhibitor used in combination with [ritonavir] and other antiretrovirals for the treatment of human immunodeficiency virus-1 (HIV-1) infection. In 1995 it became the first protease inhibitor approved by the FDA, followed shortly by ritonavir in 1996, and remains in clinical use today due... | Major | 2 | [
[
[
609,
25,
1327
]
],
[
[
609,
63,
798
],
[
798,
40,
1327
]
],
[
[
609,
62,
215
],
[
215,
40,
1327
]
],
[
[
609,
6,
10215
],
[
10215,
... | [
[
[
"Clarithromycin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Saquinavir"
]
],
[
[
"Clarithromycin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Nelfinavir"
],
[
"Ne... | Clarithromycin may cause a moderate interaction that could exacerbate diseases when taken with Nelfinavir and Nelfinavir (Compound) resembles Saquinavir (Compound)
Clarithromycin may cause a minor interaction that can limit clinical effects when taken with Indinavir and Indinavir (Compound) resembles Saquinavir (Compou... |
DB00280 | DB01362 | 494 | 497 | [
"DDInter575",
"DDInter960"
] | Disopyramide | Iohexol | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Moderate | 1 | [
[
[
494,
24,
497
]
],
[
[
494,
24,
258
],
[
258,
40,
497
]
],
[
[
494,
21,
28787
],
[
28787,
60,
497
]
],
[
[
494,
24,
999
],
[
999,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
],
[
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Iodixanol and Iodixanol (Compound) resembles Iohexol (Compound)
Disopyramide (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iohexol (Compound)
Disopyramide may cause a moderate interaction ... |
DB00501 | DB14881 | 752 | 180 | [
"DDInter380",
"DDInter1329"
] | Cimetidine | Oliceridine | A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors. Cimetidine has a range of pharmacological actions. It inhibits gastric acid secretion, as well as pepsin and gastrins output. It also blocks the activity of cytochrome P-450 which might explain proposals for use in neoadjuvant ... | Severe acute pain occurs through nociceptive signalling involving both ascending and descending spinal pathways, in which nerve conductance is mediated in part by the action of opioid receptors.[A218041, A218046] Opioid receptors are seven-transmembrane G-protein-coupled receptors (GPCRs), of which the μ-opioid recepto... | Moderate | 1 | [
[
[
752,
24,
180
]
],
[
[
752,
23,
112
],
[
112,
23,
180
]
],
[
[
752,
24,
124
],
[
124,
24,
180
]
],
[
[
752,
25,
888
],
[
888,
24,... | [
[
[
"Cimetidine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Oliceridine"
]
],
[
[
"Cimetidine",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
... | Cimetidine may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Oliceridine
Cimetidine may cause a moderate interaction that could exacerbate diseases when taken with Glasdegib and Glas... |
DB01069 | DB01263 | 401 | 859 | [
"DDInter1533",
"DDInter1494"
] | Promethazine | Posaconazole | Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of [phenothiazine] that was developed in France in 1946. Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.[A189907,A1... | Posaconazole is a triazole antifungal drug that is used to treat invasive infections by Candida species and Aspergillus species in severely immunocompromised patients. | Moderate | 1 | [
[
[
401,
24,
859
]
],
[
[
401,
6,
4973
],
[
4973,
45,
859
]
],
[
[
401,
21,
28762
],
[
28762,
60,
859
]
],
[
[
401,
62,
112
],
[
112,
... | [
[
[
"Promethazine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Posaconazole"
]
],
[
[
"Promethazine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compoun... | Promethazine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Posaconazole (Compound)
Promethazine (Compound) causes Headache (Side Effect) and Headache (Side Effect) is caused by Posaconazole (Compound)
Promethazine may cause a minor interaction that can limit clinical effects when taken with Metronidazole a... |
DB00215 | DB12245 | 1,230 | 823 | [
"DDInter388",
"DDInter1863"
] | Citalopram | Triclabendazole | Citalopram is an antidepressant belonging to the class of selective _serotonin-reuptake inhibitors_ (SSRIs) widely used to treat the symptoms of depression. It is a racemic bicyclic phthalate derivate and is the only compound with a tertiary amine and 2 nitrogen-containing metabolites among all SSRIs.[A261316,A14720] C... | Triclabendazole, manufactured by Novartis pharmaceuticals, is an antihelminthic drug that was approved by the FDA in February 2019 for the treatment of fascioliasis in humans.[FDA label, L5452] Fascioliasis is a parasitic infection often caused by the helminth, _Fasciola hepatica_, which is also known as “the common li... | Major | 2 | [
[
[
1230,
25,
823
]
],
[
[
1230,
23,
112
],
[
112,
23,
823
]
],
[
[
1230,
25,
1010
],
[
1010,
24,
823
]
],
[
[
1230,
24,
28
],
[
28,
... | [
[
[
"Citalopram",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Triclabendazole"
]
],
[
[
"Citalopram",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Metronidazole"
],
[
"Metr... | Citalopram may cause a minor interaction that can limit clinical effects when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Triclabendazole
Citalopram may lead to a major life threatening interaction when taken with Mefloquine and Mefloquine may... |
DB00934 | DB01362 | 413 | 497 | [
"DDInter1124",
"DDInter960"
] | Maprotiline | Iohexol | Maprotiline is a tetracyclic antidepressant with similar pharmacological properties to tricyclic antidepressants (TCAs). Similar to TCAs, maprotiline inhibits neuronal norepinephrine reuptake, possesses some anticholinergic activity, and does not affect monoamine oxidase activity. It differs from TCAs in that it does n... | Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality. | Major | 2 | [
[
[
413,
25,
497
]
],
[
[
413,
21,
28787
],
[
28787,
60,
497
]
],
[
[
413,
63,
999
],
[
999,
25,
497
]
],
[
[
413,
24,
1264
],
[
1264,
... | [
[
[
"Maprotiline",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Iohexol"
]
],
[
[
"Maprotiline",
"{u} (Compound) causes {v} (Side Effect)",
"Dermatitis"
],
[
"Dermatitis",
"{u} (Side Effect) is caused by {v} (Com... | Maprotiline (Compound) causes Dermatitis (Side Effect) and Dermatitis (Side Effect) is caused by Iohexol (Compound)
Maprotiline may cause a moderate interaction that could exacerbate diseases when taken with Thiethylperazine and Thiethylperazine may lead to a major life threatening interaction when taken with Iohexol
M... |
DB01611 | DB14509 | 1,487 | 1,399 | [
"DDInter893",
"DDInter1081"
] | Hydroxychloroquine | Lithium carbonate | Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like [chloroquine]. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxyc... | Lithium has been used to treat manic episodes since the 19th century. Though it is widely used, its mechanism of action is still unknown[FDA Label][A14585,A176642,A176651,L5843]. Lithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label]. | Major | 2 | [
[
[
1487,
25,
1399
]
],
[
[
1487,
63,
589
],
[
589,
23,
1399
]
],
[
[
1487,
24,
1374
],
[
1374,
24,
1399
]
],
[
[
1487,
64,
820
],
[
820,
... | [
[
[
"Hydroxychloroquine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Lithium carbonate"
]
],
[
[
"Hydroxychloroquine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Cisplatin"
],
... | Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Cisplatin and Cisplatin may cause a minor interaction that can limit clinical effects when taken with Lithium carbonate
Hydroxychloroquine may cause a moderate interaction that could exacerbate diseases when taken with Ab... |
DB11834 | DB14444 | 1,303 | 151 | [
"DDInter849",
"DDInter924"
] | Guselkumab | Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated) | Guselkumab is a human immunoglobulin G1 lambda (IgG1λ) monoclonal antibody that selectively blocks interleukin-23. IL-23 is an inflammatory cytokine that activates the CD4+ T-helper (Th17) cell pathway to mediate the inflammatory cascade that induces psoriatic plaque formation. In clinical trials, guselkumab demonstrat... | A seasonally-specific component of the influenza vaccine. The influenza vaccine, also known as the "flu shot", is a vaccine that protects against infection from the influenza viruses. Vaccines provide protection from influenza by exposing the immune system to the virus (or parts of the virus) which stimulates an immuno... | Moderate | 1 | [
[
[
1303,
24,
151
]
],
[
[
1303,
63,
66
],
[
66,
24,
151
]
],
[
[
1303,
64,
375
],
[
375,
24,
151
]
],
[
[
1303,
24,
270
],
[
270,
2... | [
[
[
"Guselkumab",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)"
]
],
[
[
"Guselkumab",
"{u} may cause a moderate interaction that could e... | Guselkumab may cause a moderate interaction that could exacerbate diseases when taken with Efalizumab and Efalizumab may cause a moderate interaction that could exacerbate diseases when taken with Influenza A virus A/California/7/2009 (H1N1)-like antigen (propiolactone inactivated)
Guselkumab may lead to a major life t... |
DB00526 | DB08903 | 1,555 | 996 | [
"DDInter1355",
"DDInter170"
] | Oxaliplatin | Bedaquiline | Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect. However, this leads to poorer water solubility, which was compensated by the addition of t... | Bedaquiline is a bactericidal antimycobacterial drug belonging to the class of diarylquinoline. The quinolinic central heterocyclic nucleus with alcohol and amine side chains is responsible for bedaquiline-mediated antimycobacterial activity. Although it is closely related to fluoroquinolones, bedaquiline does not affe... | Major | 2 | [
[
[
1555,
25,
996
]
],
[
[
1555,
24,
112
],
[
112,
23,
996
]
],
[
[
1555,
24,
713
],
[
713,
63,
996
]
],
[
[
1555,
24,
848
],
[
848,
... | [
[
[
"Oxaliplatin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Bedaquiline"
]
],
[
[
"Oxaliplatin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Metronidazole"
],
[
"Metr... | Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Metronidazole and Metronidazole may cause a minor interaction that can limit clinical effects when taken with Bedaquiline
Oxaliplatin may cause a moderate interaction that could exacerbate diseases when taken with Dimethyl fumar... |
DB00365 | DB09082 | 839 | 659 | [
"DDInter842",
"DDInter1934"
] | Grepafloxacin | Vilanterol | Grepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for cardiovascular adverse events, grepafloxacin was withdrawn in the United States. | Vilanterol is a selective long-acting β2-adrenergic agonist (LABA) with inherent 24-hour activity for the once-daily treatment of COPD and asthma. This is in response to the need for longer-acting β2-adrenergic agonists to overcome poor patient compliance (due to the frequency of dosing regimens or complexities of drug... | Moderate | 1 | [
[
[
839,
24,
659
]
],
[
[
839,
25,
1220
],
[
1220,
23,
659
]
],
[
[
839,
24,
617
],
[
617,
23,
659
]
],
[
[
839,
25,
1296
],
[
1296,
... | [
[
[
"Grepafloxacin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vilanterol"
]
],
[
[
"Grepafloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Dexamethasone"
],
[
"D... | Grepafloxacin may lead to a major life threatening interaction when taken with Dexamethasone and Dexamethasone may cause a minor interaction that can limit clinical effects when taken with Vilanterol
Grepafloxacin may cause a moderate interaction that could exacerbate diseases when taken with Budesonide and Budesonide ... |
DB00363 | DB04837 | 695 | 649 | [
"DDInter419",
"DDInter407"
] | Clozapine | Clofedanol | Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".. This low affinity to dopamine ... | Clofedanol is a centrally-acting cough suppressant available in Canada under the trade name Ulone. It is not available in the United States. | Moderate | 1 | [
[
[
695,
24,
649
]
],
[
[
695,
24,
1376
],
[
1376,
24,
649
]
],
[
[
695,
24,
832
],
[
832,
40,
649
]
],
[
[
695,
63,
701
],
[
701,
2... | [
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clofedanol"
]
],
[
[
"Clozapine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diphenhydramine"
],
[... | Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Diphenhydramine and Diphenhydramine may cause a moderate interaction that could exacerbate diseases when taken with Clofedanol
Clozapine may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamin... |
DB00280 | DB01249 | 494 | 258 | [
"DDInter575",
"DDInter958"
] | Disopyramide | Iodixanol | A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. | Iodixanol is a nonionic hydrophilic compound commonly used as a contrast agent during coronary angiography, particularly in individuals with renal dysfunction, as it is believed to be less toxic to the kidneys than most other intravascular contrast agents. | Moderate | 1 | [
[
[
494,
24,
258
]
],
[
[
494,
24,
497
],
[
497,
1,
258
]
],
[
[
494,
21,
28748
],
[
28748,
60,
258
]
],
[
[
494,
25,
485
],
[
485,
... | [
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iodixanol"
]
],
[
[
"Disopyramide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Iohexol"
],
[
... | Disopyramide may cause a moderate interaction that could exacerbate diseases when taken with Iohexol and Iohexol (Compound) resembles Iodixanol (Compound)
Disopyramide (Compound) causes Vertigo (Side Effect) and Vertigo (Side Effect) is caused by Iodixanol (Compound)
Disopyramide may lead to a major life threatening in... |
DB08873 | DB12941 | 74 | 466 | [
"DDInter221",
"DDInter481"
] | Boceprevir | Darolutamide | Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in... | Darolutamide is a nonsteroidal androgen receptor antagonist for the treatment of castrate-resistant, non-metastatic prostate cancer (nmCRPC). This condition occurs in the majority of patients with advanced prostate cancer who have been treated with androgen receptor antagonists. Though prior treatment for prostate canc... | Moderate | 1 | [
[
[
74,
24,
466
]
],
[
[
74,
62,
1374
],
[
1374,
23,
466
]
],
[
[
74,
25,
351
],
[
351,
23,
466
]
],
[
[
74,
63,
86
],
[
86,
23,
... | [
[
[
"Boceprevir",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Darolutamide"
]
],
[
[
"Boceprevir",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Abiraterone"
],
[
... | Boceprevir may cause a minor interaction that can limit clinical effects when taken with Abiraterone and Abiraterone may cause a minor interaction that can limit clinical effects when taken with Darolutamide
Boceprevir may lead to a major life threatening interaction when taken with Ribociclib and Ribociclib may cause ... |
DB01125 | DB03619 | 279 | 557 | [
"DDInter98",
"DDInter501"
] | Anisindione | Deoxycholic acid | Anisindione is a synthetic anticoagulant and an indanedione derivative. Its anticoagulant action is mediated through the inhibition of the vitamin K-mediated gamma-carboxylation of precursor proteins that are critical in forming the formation of active procoagulation factors II, VII, IX, and X, as well as the anticoagu... | Deoxycholic acid is a a bile acid which emulsifies and solubilizes dietary fats in the intestine, and when injected subcutaneously, it disrupts cell membranes in adipocytes and destroys fat cells in that tissue. In April 2015, deoxycholic acid was approved by the FDA for the treatment submental fat to improve aesthetic... | Moderate | 1 | [
[
[
279,
24,
557
]
],
[
[
279,
64,
1479
],
[
1479,
24,
557
]
],
[
[
279,
25,
405
],
[
405,
63,
557
]
],
[
[
279,
25,
500
],
[
500,
2... | [
[
[
"Anisindione",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Deoxycholic acid"
]
],
[
[
"Anisindione",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Acetylsalicylic acid"
],
[... | Anisindione may lead to a major life threatening interaction when taken with Acetylsalicylic acid and Acetylsalicylic acid may cause a moderate interaction that could exacerbate diseases when taken with Deoxycholic acid
Anisindione may lead to a major life threatening interaction when taken with Acalabrutinib and Acala... |
DB00250 | DB06414 | 10 | 655 | [
"DDInter475",
"DDInter703"
] | Dapsone | Etravirine | A sulfone active against a wide range of bacteria but mainly employed for its actions against mycobacterium leprae. Its mechanism of action is probably similar to that of the sulfonamides which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with pyrimethamine in the treatment of m... | Etravirine is an antiretroviral agent more specifically classified as a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI). Etraverine is used clinically for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. On January 18, 2007, the FDA granted accelerated approved for the use of etravirine 10... | Moderate | 1 | [
[
[
10,
24,
655
]
],
[
[
10,
6,
6017
],
[
6017,
45,
655
]
],
[
[
10,
21,
28722
],
[
28722,
60,
655
]
],
[
[
10,
63,
168
],
[
168,
23... | [
[
[
"Dapsone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Etravirine"
]
],
[
[
"Dapsone",
"{u} (Compound) binds {v} (Gene)",
"CYP2C9"
],
[
"CYP2C9",
"{u} (Gene) is bound by {v} (Compound)",
... | Dapsone (Compound) binds CYP2C9 (Gene) and CYP2C9 (Gene) is bound by Etravirine (Compound)
Dapsone (Compound) causes Nausea (Side Effect) and Nausea (Side Effect) is caused by Etravirine (Compound)
Dapsone may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezomib may caus... |
DB00081 | DB01050 | 273 | 848 | [
"DDInter1838",
"DDInter900"
] | Tositumomab | Ibuprofen | Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine). | Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) derived from propionic acid and it is considered the first of the propionics. The formula of ibuprofen is 2-(4-isobutylphenyl) propionic acid and its initial development was in 1960 while researching for a safer alternative for aspirin. Ibuprofen was finally p... | Major | 2 | [
[
[
273,
25,
848
]
],
[
[
273,
25,
831
],
[
831,
24,
848
]
],
[
[
273,
64,
20
],
[
20,
24,
848
]
],
[
[
273,
24,
643
],
[
643,
63,
... | [
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Ibuprofen"
]
],
[
[
"Tositumomab",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Indomethacin"
],
[
"Indomethacin",
"... | Tositumomab may lead to a major life threatening interaction when taken with Indomethacin and Indomethacin may cause a moderate interaction that could exacerbate diseases when taken with Ibuprofen
Tositumomab may lead to a major life threatening interaction when taken with Tenecteplase and Tenecteplase may cause a mode... |
DB11837 | DB14575 | 1,297 | 733 | [
"DDInter1351",
"DDInter674"
] | Osilodrostat | Eslicarbazepine | Osilodrostat is an inhibitor of 11β-hydroxylase (also referred to as CYP11B1), the enzyme that catalyzes the final step in the biosynthesis of endogenous cortisol. It is used to lower circulating cortisol levels in the treatment of Cushing's disease, a disorder in which cortisol levels are chronically and supraphysiolo... | Eslicarbazepine is an anti-epileptic medication available commercially as [eslicarbazepine acetate]. | Moderate | 1 | [
[
[
1297,
24,
733
]
],
[
[
1297,
63,
1101
],
[
1101,
23,
733
]
],
[
[
1297,
63,
1264
],
[
1264,
24,
733
]
],
[
[
1297,
62,
222
],
[
222,
... | [
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eslicarbazepine"
]
],
[
[
"Osilodrostat",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],... | Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a minor interaction that can limit clinical effects when taken with Eslicarbazepine
Osilodrostat may cause a moderate interaction that could exacerbate diseases when taken with Doxepin and Do... |
DB01024 | DB01602 | 1,096 | 339 | [
"DDInter1252",
"DDInter159"
] | Mycophenolic acid | Bacampicillin | Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis. It was derived from _Penicillium stoloniferum_, and has also shown antibacterial, antifungal and antiviral properties.. Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a c... | Bacampicillin is a prodrug of ampicillin and is microbiologically inactive. It is absorbed following oral administration. During absorption from the gastrointestinal tract, bacampicillin is hydrolyzed by esterases present in the intestinal wall. It is microbiologically active as ampicillin, and exerts a bactericidal ac... | Moderate | 1 | [
[
[
1096,
24,
339
]
],
[
[
1096,
63,
703
],
[
703,
1,
339
]
],
[
[
1096,
24,
950
],
[
950,
40,
339
]
],
[
[
1096,
63,
916
],
[
916,
... | [
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bacampicillin"
]
],
[
[
"Mycophenolic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Carbenicil... | Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Carbenicillin and Carbenicillin (Compound) resembles Bacampicillin (Compound)
Mycophenolic acid may cause a moderate interaction that could exacerbate diseases when taken with Cloxacillin and Cloxacillin (Compound) resembl... |
DB01059 | DB05294 | 956 | 1,069 | [
"DDInter1313",
"DDInter1917"
] | Norfloxacin | Vandetanib | A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase. | Vandetanib is an oral once-daily kinase inhibitor of tumour angiogenesis and tumour cell proliferation with the potential for use in a broad range of tumour types. On April 6 2011, vandetanib was approved by the FDA to treat nonresectable, locally advanced, or metastatic medullary thyroid cancer in adult patients. | Major | 2 | [
[
[
956,
25,
1069
]
],
[
[
956,
6,
8374
],
[
8374,
45,
1069
]
],
[
[
956,
21,
29343
],
[
29343,
60,
1069
]
],
[
[
956,
62,
112
],
[
112,
... | [
[
[
"Norfloxacin",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Vandetanib"
]
],
[
[
"Norfloxacin",
"{u} (Compound) binds {v} (Gene)",
"CYP3A4"
],
[
"CYP3A4",
"{u} (Gene) is bound by {v} (Compound)",
"Vande... | Norfloxacin (Compound) binds CYP3A4 (Gene) and CYP3A4 (Gene) is bound by Vandetanib (Compound)
Norfloxacin (Compound) causes Blood creatinine increased (Side Effect) and Blood creatinine increased (Side Effect) is caused by Vandetanib (Compound)
Norfloxacin may cause a minor interaction that can limit clinical effects ... |
DB00656 | DB00835 | 827 | 100 | [
"DDInter1851",
"DDInter245"
] | Trazodone | Brompheniramine | Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants. It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and se... | Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. | Moderate | 1 | [
[
[
827,
24,
100
]
],
[
[
827,
24,
832
],
[
832,
24,
100
]
],
[
[
827,
63,
128
],
[
128,
24,
100
]
],
[
[
827,
24,
28
],
[
28,
40,
... | [
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Brompheniramine"
]
],
[
[
"Trazodone",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tripelennamine"
],
... | Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Tripelennamine and Tripelennamine may cause a moderate interaction that could exacerbate diseases when taken with Brompheniramine
Trazodone may cause a moderate interaction that could exacerbate diseases when taken with Dexbromphe... |
DB00059 | DB00740 | 1,560 | 424 | [
"DDInter1404",
"DDInter1596"
] | Pegaspargase | Riluzole | Pegaspargase is a conjugate of monomethoxypolyethylene glycol (mPEG) and L-asparaginase (L-asparagine amidohydrolase), an asparagine-specific enzyme that converts L-asparagine into aspartic acid and ammonia. Asparagine is an amino acid that is vital for cell survival. In humans, most normal tissues can produce asparagi... | A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. Riluzole is marketed as Rilutek by Sanofi. | Moderate | 1 | [
[
[
1560,
24,
424
]
],
[
[
1560,
24,
482
],
[
482,
24,
424
]
],
[
[
1560,
24,
868
],
[
868,
63,
424
]
],
[
[
1560,
25,
1377
],
[
1377,
... | [
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Riluzole"
]
],
[
[
"Pegaspargase",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Tioguanine"
],
[
... | Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Tioguanine and Tioguanine may cause a moderate interaction that could exacerbate diseases when taken with Riluzole
Pegaspargase may cause a moderate interaction that could exacerbate diseases when taken with Vemurafenib and Vem... |
DB00635 | DB08938 | 1,573 | 1,384 | [
"DDInter1515",
"DDInter1112"
] | Prednisone | Magaldrate | A synthetic anti-inflammatory glucocorticoid derived from [cortisone]. It is biologically inert and converted to [prednisolone] in the liver. Prednisone was granted FDA approval on 21 February 1955. | Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market. | Minor | 0 | [
[
[
1573,
23,
1384
]
],
[
[
1573,
40,
167
],
[
167,
23,
1384
]
],
[
[
1573,
24,
699
],
[
699,
23,
1384
]
],
[
[
1573,
63,
461
],
[
461,
... | [
[
[
"Prednisone",
"{u} may cause a minor interaction that can limit clinical effects when taken with {v}",
"Magaldrate"
]
],
[
[
"Prednisone",
"{u} (Compound) resembles {v} (Compound)",
"Hydrocortisone"
],
[
"Hydrocortisone",
"{u} may cause a m... | Prednisone (Compound) resembles Hydrocortisone (Compound) and Hydrocortisone may cause a minor interaction that can limit clinical effects when taken with Magaldrate
Prednisone may cause a moderate interaction that could exacerbate diseases when taken with Nadolol and Nadolol may cause a minor interaction that can limi... |
DB06772 | DB14443 | 310 | 987 | [
"DDInter259",
"DDInter1931"
] | Cabazitaxel | Vibrio cholerae CVD 103-HgR strain live antigen | Cabazitaxel is a taxoid synthesized from 10-deacetylbaccatin III, a compound isolated from the yew tree. As a second-generation semisynthetic microtubule inhibitor, cabazitaxel stabilizes microtubules and induces tumour cell death. Due to its low affinity for the P-glycoprotein (P-gp) efflux pump, cabazitaxel can more ... | _Vibrio cholerae_ CVD 103-HgR strain live antigen is a component of Vaxchora, an oral vaccine for immunization against _Vibrio cholerae_ serogroup O1. Cholera is an acute bacterial disease of the small intestine caused by _Vibrio cholerae_, which is gram-negative bacteria. Two serogroups of _V. cholerae_, O1 and O139, ... | Moderate | 1 | [
[
[
310,
24,
987
]
],
[
[
310,
24,
1480
],
[
1480,
24,
987
]
],
[
[
310,
63,
1488
],
[
1488,
24,
987
]
],
[
[
310,
64,
581
],
[
581,
... | [
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Vibrio cholerae CVD 103-HgR strain live antigen"
]
],
[
[
"Cabazitaxel",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {... | Cabazitaxel may cause a moderate interaction that could exacerbate diseases when taken with Ixazomib and Ixazomib may cause a moderate interaction that could exacerbate diseases when taken with Vibrio cholerae CVD 103-HgR strain live antigen
Cabazitaxel may cause a moderate interaction that could exacerbate diseases wh... |
DB00773 | DB14783 | 896 | 287 | [
"DDInter702",
"DDInter574"
] | Etoposide | Diroximel fumarate | A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitoti... | Multiple Sclerosis (MS) is a chronic, debilitating neurological disease that can lead to profound cognitive and physical symptoms, severely affecting quality of life. It is the main cause of neurological disability not caused by trauma in the young adult population of both North America and Europe. Relapsing-remitting ... | Moderate | 1 | [
[
[
896,
24,
287
]
],
[
[
896,
63,
1101
],
[
1101,
24,
287
]
],
[
[
896,
24,
384
],
[
384,
24,
287
]
],
[
[
896,
62,
147
],
[
147,
2... | [
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Diroximel fumarate"
]
],
[
[
"Etoposide",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Bexarotene"
],
... | Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Bexarotene and Bexarotene may cause a moderate interaction that could exacerbate diseases when taken with Diroximel fumarate
Etoposide may cause a moderate interaction that could exacerbate diseases when taken with Idelalisib and ... |
DB01157 | DB10583 | 304 | 949 | [
"DDInter1875",
"DDInter415"
] | Trimetrexate | Clostridium tetani toxoid antigen (formaldehyde inactivated) | A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect. | Clostridium tetani toxoid antigen (formaldehyde inactivated) is a vaccine for intramuscular injection. It is used for active immunization of children 7 years of age or older, and adults, for prevention of tetanus. The toxoid in the Clostridium tetani culture is grown and detoxified followed by purification via ammonium... | Moderate | 1 | [
[
[
304,
24,
949
]
],
[
[
304,
64,
1377
],
[
1377,
24,
949
]
],
[
[
304,
63,
58
],
[
58,
24,
949
]
],
[
[
304,
25,
1259
],
[
1259,
6... | [
[
[
"Trimetrexate",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Clostridium tetani toxoid antigen (formaldehyde inactivated)"
]
],
[
[
"Trimetrexate",
"{u} may lead to a major life threatening interaction when taken with {... | Trimetrexate may lead to a major life threatening interaction when taken with Leflunomide and Leflunomide may cause a moderate interaction that could exacerbate diseases when taken with Clostridium tetani toxoid antigen (formaldehyde inactivated)
Trimetrexate may cause a moderate interaction that could exacerbate disea... |
DB00939 | DB01082 | 1,338 | 1,448 | [
"DDInter1135",
"DDInter1713"
] | Meclofenamic acid | Streptomycin | A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. | Streptomycin, an antibiotic derived from _Streptomyces griseus_, was the first aminoglycoside to be discovered and used in practice in the 1940s.[A233325,A233390] Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activi... | Moderate | 1 | [
[
[
1338,
24,
1448
]
],
[
[
1338,
6,
10612
],
[
10612,
45,
1448
]
],
[
[
1338,
21,
29327
],
[
29327,
60,
1448
]
],
[
[
1338,
24,
1272
],
[
... | [
[
[
"Meclofenamic acid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Streptomycin"
]
],
[
[
"Meclofenamic acid",
"{u} (Compound) binds {v} (Gene)",
"SLC22A6"
],
[
"SLC22A6",
"{u} (Gene) is bound b... | Meclofenamic acid (Compound) binds SLC22A6 (Gene) and SLC22A6 (Gene) is bound by Streptomycin (Compound)
Meclofenamic acid (Compound) causes Renal failure (Side Effect) and Renal failure (Side Effect) is caused by Streptomycin (Compound)
Meclofenamic acid may cause a moderate interaction that could exacerbate diseases ... |
DB00863 | DB01072 | 1,194 | 915 | [
"DDInter1568",
"DDInter129"
] | Ranitidine | Atazanavir | Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as [cimetidine] and [famotidine]. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.[A176759,L10818]... | Atazanavir (formerly known as BMS-232632) is an antiretroviral drug of the protease inhibitor (PI) class. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Atazanavir is distinguished from other PIs in that it can be given once daily (rather than requiring multiple doses p... | Major | 2 | [
[
[
1194,
25,
915
]
],
[
[
1194,
6,
4973
],
[
4973,
45,
915
]
],
[
[
1194,
21,
28678
],
[
28678,
60,
915
]
],
[
[
1194,
63,
1031
],
[
1031... | [
[
[
"Ranitidine",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Atazanavir"
]
],
[
[
"Ranitidine",
"{u} (Compound) binds {v} (Gene)",
"ABCB1"
],
[
"ABCB1",
"{u} (Gene) is bound by {v} (Compound)",
"Atazanavi... | Ranitidine (Compound) binds ABCB1 (Gene) and ABCB1 (Gene) is bound by Atazanavir (Compound)
Ranitidine (Compound) causes Hepatocellular injury (Side Effect) and Hepatocellular injury (Side Effect) is caused by Atazanavir (Compound)
Ranitidine may cause a moderate interaction that could exacerbate diseases when taken wi... |
DB00757 | DB12010 | 1,166 | 214 | [
"DDInter581",
"DDInter785"
] | Dolasetron | Fostamatinib | Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug is no... | Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP [L2644, FDA Label]. Fostamatinib has also been granted orphan drug status by the FDA . Recently, fost... | Moderate | 1 | [
[
[
1166,
24,
214
]
],
[
[
1166,
64,
1428
],
[
1428,
24,
214
]
],
[
[
1166,
62,
690
],
[
690,
24,
214
]
],
[
[
1166,
25,
1373
],
[
1373,
... | [
[
[
"Dolasetron",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fostamatinib"
]
],
[
[
"Dolasetron",
"{u} may lead to a major life threatening interaction when taken with {v}",
"Isradipine"
],
[
"Isradipi... | Dolasetron may lead to a major life threatening interaction when taken with Isradipine and Isradipine may cause a moderate interaction that could exacerbate diseases when taken with Fostamatinib
Dolasetron may cause a minor interaction that can limit clinical effects when taken with Rifabutin and Rifabutin may cause a ... |
DB00747 | DB01209 | 1,442 | 1,359 | [
"DDInter1647",
"DDInter531"
] | Scopolamine | Dezocine | Scopolamine is a tropane alkaloid isolated from members of the _Solanaceae_ family of plants, similar to [atropine] and [hyoscyamine], all of which structurally mimic the natural neurotransmitter [acetylcholine].[A228423, A228763] Scopolamine was first synthesized in 1959, but to date, synthesis remains less efficient ... | Dezocine is a partial opiate drug and is used for pain management. Dezocine is a very effective alternative to fentanyl when administered during outpatient laparoscopy, although is associated with an increased incidence of postoperative nausea. | Moderate | 1 | [
[
[
1442,
24,
1359
]
],
[
[
1442,
63,
234
],
[
234,
1,
1359
]
],
[
[
1442,
24,
262
],
[
262,
24,
1359
]
],
[
[
1442,
63,
1594
],
[
1594,
... | [
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Dezocine"
]
],
[
[
"Scopolamine",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Pentazocine"
],
[
... | Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Pentazocine and Pentazocine (Compound) resembles Dezocine (Compound)
Scopolamine may cause a moderate interaction that could exacerbate diseases when taken with Clidinium and Clidinium may cause a moderate interaction that could... |
DB00951 | DB08871 | 1,072 | 36 | [
"DDInter986",
"DDInter666"
] | Isoniazid | Eribulin | Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis. | Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for... | Moderate | 1 | [
[
[
1072,
24,
36
]
],
[
[
1072,
24,
1488
],
[
1488,
24,
36
]
],
[
[
1072,
63,
168
],
[
168,
24,
36
]
],
[
[
1072,
24,
384
],
[
384,
... | [
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Eribulin"
]
],
[
[
"Isoniazid",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Fludarabine"
],
[
... | Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Fludarabine and Fludarabine may cause a moderate interaction that could exacerbate diseases when taken with Eribulin
Isoniazid may cause a moderate interaction that could exacerbate diseases when taken with Bortezomib and Bortezom... |
DB00694 | DB00816 | 51 | 1,674 | [
"DDInter485",
"DDInter1346"
] | Daunorubicin | Orciprenaline | A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of leukemia and other neoplasms. | A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem] | Moderate | 1 | [
[
[
51,
24,
1674
]
],
[
[
51,
18,
6461
],
[
6461,
46,
1674
]
],
[
[
51,
21,
28921
],
[
28921,
60,
1674
]
],
[
[
51,
24,
1164
],
[
1164,
... | [
[
[
"Daunorubicin",
"{u} may cause a moderate interaction that could exacerbate diseases when taken with {v}",
"Orciprenaline"
]
],
[
[
"Daunorubicin",
"{u} (Compound) downregulates {v} (Gene)",
"DDX10"
],
[
"DDX10",
"{u} (Gene) is upregulated ... | Daunorubicin (Compound) downregulates DDX10 (Gene) and DDX10 (Gene) is upregulated by Orciprenaline (Compound)
Daunorubicin (Compound) causes Dizziness (Side Effect) and Dizziness (Side Effect) is caused by Orciprenaline (Compound)
Daunorubicin may cause a moderate interaction that could exacerbate diseases when taken ... |
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