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31400 | Could CRISPR cure HIV someday?
Scientists have been experimenting with how to use CRISPR to treat and potentially cure HIV since the gene-editing tool was developed.
In an ongoing clinical trial , researchers are testing whether just one dose of a new gene therapy that might effectively cure human immunodeficiency virus ( HIV ) infections is safe in humans.
The therapy, named EBT-101, involves using CRISPR-Cas9 gene editing to treat HIV. This potential treatment strategy has been studied in animal models since the development of CRISPR-Cas9 in 2012. However, this is the first time such a gene-editing treatment for HIV has been tried in humans. The latest data from the trial suggest that EBT-101 is safe at the doses tested, but we don't yet know if it cures HIV.
According to the United Nations Programme on HIV/AIDS (UNAIDS) , approximately 39 million people globally were living with HIV in 2022, and there were about 630,000 AIDS-related deaths that year, making HIV a continued public health burden. |
31401 | Could CRISPR cure HIV someday?
In an ongoing clinical trial , researchers are testing whether just one dose of a new gene therapy that might effectively cure human immunodeficiency virus ( HIV ) infections is safe in humans.
The therapy, named EBT-101, involves using CRISPR-Cas9 gene editing to treat HIV. This potential treatment strategy has been studied in animal models since the development of CRISPR-Cas9 in 2012. However, this is the first time such a gene-editing treatment for HIV has been tried in humans. The latest data from the trial suggest that EBT-101 is safe at the doses tested, but we don't yet know if it cures HIV.
According to the United Nations Programme on HIV/AIDS (UNAIDS) , approximately 39 million people globally were living with HIV in 2022, and there were about 630,000 AIDS-related deaths that year, making HIV a continued public health burden. There is no vaccine or easily accessible cure for HIV, although a handful of people have been effectively cured through intensive stem-cell transplants. |
31402 | Could CRISPR cure HIV someday?
The therapy, named EBT-101, involves using CRISPR-Cas9 gene editing to treat HIV. This potential treatment strategy has been studied in animal models since the development of CRISPR-Cas9 in 2012. However, this is the first time such a gene-editing treatment for HIV has been tried in humans. The latest data from the trial suggest that EBT-101 is safe at the doses tested, but we don't yet know if it cures HIV.
According to the United Nations Programme on HIV/AIDS (UNAIDS) , approximately 39 million people globally were living with HIV in 2022, and there were about 630,000 AIDS-related deaths that year, making HIV a continued public health burden. There is no vaccine or easily accessible cure for HIV, although a handful of people have been effectively cured through intensive stem-cell transplants.
The EBT-101 trial "is an important step forward in the development of this technology to treat human disease and infection, including HIV," Thomas Hope , a professor of cell and developmental biology at Northwestern University who was not involved in the work, told Live Science in an email. |
31403 | Could CRISPR cure HIV someday?
However, this is the first time such a gene-editing treatment for HIV has been tried in humans. The latest data from the trial suggest that EBT-101 is safe at the doses tested, but we don't yet know if it cures HIV.
According to the United Nations Programme on HIV/AIDS (UNAIDS) , approximately 39 million people globally were living with HIV in 2022, and there were about 630,000 AIDS-related deaths that year, making HIV a continued public health burden. There is no vaccine or easily accessible cure for HIV, although a handful of people have been effectively cured through intensive stem-cell transplants.
The EBT-101 trial "is an important step forward in the development of this technology to treat human disease and infection, including HIV," Thomas Hope , a professor of cell and developmental biology at Northwestern University who was not involved in the work, told Live Science in an email.
But how likely is it, really, that we could use CRISPR to cure HIV someday? |
31404 | Could CRISPR cure HIV someday?
The latest data from the trial suggest that EBT-101 is safe at the doses tested, but we don't yet know if it cures HIV.
According to the United Nations Programme on HIV/AIDS (UNAIDS) , approximately 39 million people globally were living with HIV in 2022, and there were about 630,000 AIDS-related deaths that year, making HIV a continued public health burden. There is no vaccine or easily accessible cure for HIV, although a handful of people have been effectively cured through intensive stem-cell transplants.
The EBT-101 trial "is an important step forward in the development of this technology to treat human disease and infection, including HIV," Thomas Hope , a professor of cell and developmental biology at Northwestern University who was not involved in the work, told Live Science in an email.
But how likely is it, really, that we could use CRISPR to cure HIV someday?
Related: We could end the AIDS epidemic in less than a decade. Here's how. |
31405 | Could CRISPR cure HIV someday?
According to the United Nations Programme on HIV/AIDS (UNAIDS) , approximately 39 million people globally were living with HIV in 2022, and there were about 630,000 AIDS-related deaths that year, making HIV a continued public health burden. There is no vaccine or easily accessible cure for HIV, although a handful of people have been effectively cured through intensive stem-cell transplants.
The EBT-101 trial "is an important step forward in the development of this technology to treat human disease and infection, including HIV," Thomas Hope , a professor of cell and developmental biology at Northwestern University who was not involved in the work, told Live Science in an email.
But how likely is it, really, that we could use CRISPR to cure HIV someday?
Related: We could end the AIDS epidemic in less than a decade. Here's how.
How CRISPR could (theoretically) cure HIV
HIV infects immune cells that are normally used to fight infection in the virus's host. |
31406 | Could CRISPR cure HIV someday?
There is no vaccine or easily accessible cure for HIV, although a handful of people have been effectively cured through intensive stem-cell transplants.
The EBT-101 trial "is an important step forward in the development of this technology to treat human disease and infection, including HIV," Thomas Hope , a professor of cell and developmental biology at Northwestern University who was not involved in the work, told Live Science in an email.
But how likely is it, really, that we could use CRISPR to cure HIV someday?
Related: We could end the AIDS epidemic in less than a decade. Here's how.
How CRISPR could (theoretically) cure HIV
HIV infects immune cells that are normally used to fight infection in the virus's host. The virus uses an immune cell's machinery to insert its own DNA into the host's genome, allowing the virus to replicate. |
31407 | Could CRISPR cure HIV someday?
There is no vaccine or easily accessible cure for HIV, although a handful of people have been effectively cured through intensive stem-cell transplants.
The EBT-101 trial "is an important step forward in the development of this technology to treat human disease and infection, including HIV," Thomas Hope , a professor of cell and developmental biology at Northwestern University who was not involved in the work, told Live Science in an email.
But how likely is it, really, that we could use CRISPR to cure HIV someday?
Related: We could end the AIDS epidemic in less than a decade. Here's how.
How CRISPR could (theoretically) cure HIV
HIV infects immune cells that are normally used to fight infection in the virus's host. The virus uses an immune cell's machinery to insert its own DNA into the host's genome, allowing the virus to replicate. If an HIV infection is not treated, it can lead to acquired immunodeficiency syndrome (AIDS), which results in a severely weakened immune system and leaves the infected person highly vulnerable to other infections, cancers and early death. |
31408 | Could CRISPR cure HIV someday?
The EBT-101 trial "is an important step forward in the development of this technology to treat human disease and infection, including HIV," Thomas Hope , a professor of cell and developmental biology at Northwestern University who was not involved in the work, told Live Science in an email.
But how likely is it, really, that we could use CRISPR to cure HIV someday?
Related: We could end the AIDS epidemic in less than a decade. Here's how.
How CRISPR could (theoretically) cure HIV
HIV infects immune cells that are normally used to fight infection in the virus's host. The virus uses an immune cell's machinery to insert its own DNA into the host's genome, allowing the virus to replicate. If an HIV infection is not treated, it can lead to acquired immunodeficiency syndrome (AIDS), which results in a severely weakened immune system and leaves the infected person highly vulnerable to other infections, cancers and early death.
Combination antiretroviral therapies (cARTs) are the mainstay in HIV treatment and limit the virus' replication, thus extending people's lives to near-normal lengths and cutting their chance of spreading HIV . |
31409 | Could CRISPR cure HIV someday?
But how likely is it, really, that we could use CRISPR to cure HIV someday?
Related: We could end the AIDS epidemic in less than a decade. Here's how.
How CRISPR could (theoretically) cure HIV
HIV infects immune cells that are normally used to fight infection in the virus's host. The virus uses an immune cell's machinery to insert its own DNA into the host's genome, allowing the virus to replicate. If an HIV infection is not treated, it can lead to acquired immunodeficiency syndrome (AIDS), which results in a severely weakened immune system and leaves the infected person highly vulnerable to other infections, cancers and early death.
Combination antiretroviral therapies (cARTs) are the mainstay in HIV treatment and limit the virus' replication, thus extending people's lives to near-normal lengths and cutting their chance of spreading HIV . However, these therapies must be taken for a lifetime and fall short of being a cure . |
31410 | Could CRISPR cure HIV someday?
Related: We could end the AIDS epidemic in less than a decade. Here's how.
How CRISPR could (theoretically) cure HIV
HIV infects immune cells that are normally used to fight infection in the virus's host. The virus uses an immune cell's machinery to insert its own DNA into the host's genome, allowing the virus to replicate. If an HIV infection is not treated, it can lead to acquired immunodeficiency syndrome (AIDS), which results in a severely weakened immune system and leaves the infected person highly vulnerable to other infections, cancers and early death.
Combination antiretroviral therapies (cARTs) are the mainstay in HIV treatment and limit the virus' replication, thus extending people's lives to near-normal lengths and cutting their chance of spreading HIV . However, these therapies must be taken for a lifetime and fall short of being a cure .
"The existing challenge in HIV treatment lies in the virus creating resilient genetic reservoirs within human cells," Elena Herrera-Carrillo , an associate professor of infectious disease at Amsterdam University Medical Centers, told Live Science. |
31411 | Could CRISPR cure HIV someday?
The virus uses an immune cell's machinery to insert its own DNA into the host's genome, allowing the virus to replicate. If an HIV infection is not treated, it can lead to acquired immunodeficiency syndrome (AIDS), which results in a severely weakened immune system and leaves the infected person highly vulnerable to other infections, cancers and early death.
Combination antiretroviral therapies (cARTs) are the mainstay in HIV treatment and limit the virus' replication, thus extending people's lives to near-normal lengths and cutting their chance of spreading HIV . However, these therapies must be taken for a lifetime and fall short of being a cure .
"The existing challenge in HIV treatment lies in the virus creating resilient genetic reservoirs within human cells," Elena Herrera-Carrillo , an associate professor of infectious disease at Amsterdam University Medical Centers, told Live Science. Herrera-Carrillo's lab focuses on using CRISPR to edit cells that harbor HIV reservoirs, despite ongoing cART therapy. |
31412 | Could CRISPR cure HIV someday?
If an HIV infection is not treated, it can lead to acquired immunodeficiency syndrome (AIDS), which results in a severely weakened immune system and leaves the infected person highly vulnerable to other infections, cancers and early death.
Combination antiretroviral therapies (cARTs) are the mainstay in HIV treatment and limit the virus' replication, thus extending people's lives to near-normal lengths and cutting their chance of spreading HIV . However, these therapies must be taken for a lifetime and fall short of being a cure .
"The existing challenge in HIV treatment lies in the virus creating resilient genetic reservoirs within human cells," Elena Herrera-Carrillo , an associate professor of infectious disease at Amsterdam University Medical Centers, told Live Science. Herrera-Carrillo's lab focuses on using CRISPR to edit cells that harbor HIV reservoirs, despite ongoing cART therapy. This phenomenon is known as "latent HIV" and occurs when the virus infects a type of immune cell called CD4+ memory T cells, which can persist for decades . |
31413 | Could CRISPR cure HIV someday?
Combination antiretroviral therapies (cARTs) are the mainstay in HIV treatment and limit the virus' replication, thus extending people's lives to near-normal lengths and cutting their chance of spreading HIV . However, these therapies must be taken for a lifetime and fall short of being a cure .
"The existing challenge in HIV treatment lies in the virus creating resilient genetic reservoirs within human cells," Elena Herrera-Carrillo , an associate professor of infectious disease at Amsterdam University Medical Centers, told Live Science. Herrera-Carrillo's lab focuses on using CRISPR to edit cells that harbor HIV reservoirs, despite ongoing cART therapy. This phenomenon is known as "latent HIV" and occurs when the virus infects a type of immune cell called CD4+ memory T cells, which can persist for decades .
cART therapies can suppress viral replication, but if the treatment is interrupted, "the dormant proviruses can reactivate, making a cure elusive," Herrera-Carrillo told Live Science. |
31414 | Could CRISPR cure HIV someday?
However, these therapies must be taken for a lifetime and fall short of being a cure .
"The existing challenge in HIV treatment lies in the virus creating resilient genetic reservoirs within human cells," Elena Herrera-Carrillo , an associate professor of infectious disease at Amsterdam University Medical Centers, told Live Science. Herrera-Carrillo's lab focuses on using CRISPR to edit cells that harbor HIV reservoirs, despite ongoing cART therapy. This phenomenon is known as "latent HIV" and occurs when the virus infects a type of immune cell called CD4+ memory T cells, which can persist for decades .
cART therapies can suppress viral replication, but if the treatment is interrupted, "the dormant proviruses can reactivate, making a cure elusive," Herrera-Carrillo told Live Science.
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. |
31415 | Could CRISPR cure HIV someday?
"The existing challenge in HIV treatment lies in the virus creating resilient genetic reservoirs within human cells," Elena Herrera-Carrillo , an associate professor of infectious disease at Amsterdam University Medical Centers, told Live Science. Herrera-Carrillo's lab focuses on using CRISPR to edit cells that harbor HIV reservoirs, despite ongoing cART therapy. This phenomenon is known as "latent HIV" and occurs when the virus infects a type of immune cell called CD4+ memory T cells, which can persist for decades .
cART therapies can suppress viral replication, but if the treatment is interrupted, "the dormant proviruses can reactivate, making a cure elusive," Herrera-Carrillo told Live Science.
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. This either deactivates the gene or allows it to be removed and swapped for different DNA. |
31416 | Could CRISPR cure HIV someday?
Herrera-Carrillo's lab focuses on using CRISPR to edit cells that harbor HIV reservoirs, despite ongoing cART therapy. This phenomenon is known as "latent HIV" and occurs when the virus infects a type of immune cell called CD4+ memory T cells, which can persist for decades .
cART therapies can suppress viral replication, but if the treatment is interrupted, "the dormant proviruses can reactivate, making a cure elusive," Herrera-Carrillo told Live Science.
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. This either deactivates the gene or allows it to be removed and swapped for different DNA. Research groups believe this strategy could be effective in removing latent HIV infections, because it can target the viral DNA embedded in the genome, rather than only stopping replication. |
31417 | Could CRISPR cure HIV someday?
Herrera-Carrillo's lab focuses on using CRISPR to edit cells that harbor HIV reservoirs, despite ongoing cART therapy. This phenomenon is known as "latent HIV" and occurs when the virus infects a type of immune cell called CD4+ memory T cells, which can persist for decades .
cART therapies can suppress viral replication, but if the treatment is interrupted, "the dormant proviruses can reactivate, making a cure elusive," Herrera-Carrillo told Live Science.
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. This either deactivates the gene or allows it to be removed and swapped for different DNA. Research groups believe this strategy could be effective in removing latent HIV infections, because it can target the viral DNA embedded in the genome, rather than only stopping replication.
Using CRISPR for HIV gene therapy has shown promise in several test-tube studies, a 2020 review in The Journal of Clinical Investigation notes. |
31418 | Could CRISPR cure HIV someday?
This phenomenon is known as "latent HIV" and occurs when the virus infects a type of immune cell called CD4+ memory T cells, which can persist for decades .
cART therapies can suppress viral replication, but if the treatment is interrupted, "the dormant proviruses can reactivate, making a cure elusive," Herrera-Carrillo told Live Science.
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. This either deactivates the gene or allows it to be removed and swapped for different DNA. Research groups believe this strategy could be effective in removing latent HIV infections, because it can target the viral DNA embedded in the genome, rather than only stopping replication.
Using CRISPR for HIV gene therapy has shown promise in several test-tube studies, a 2020 review in The Journal of Clinical Investigation notes. Various groups have been working to bring the therapies from test tubes to human patients — and that brings us to EBT-101. |
31419 | Could CRISPR cure HIV someday?
cART therapies can suppress viral replication, but if the treatment is interrupted, "the dormant proviruses can reactivate, making a cure elusive," Herrera-Carrillo told Live Science.
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. This either deactivates the gene or allows it to be removed and swapped for different DNA. Research groups believe this strategy could be effective in removing latent HIV infections, because it can target the viral DNA embedded in the genome, rather than only stopping replication.
Using CRISPR for HIV gene therapy has shown promise in several test-tube studies, a 2020 review in The Journal of Clinical Investigation notes. Various groups have been working to bring the therapies from test tubes to human patients — and that brings us to EBT-101.
Related: The world's 1st CRISPR therapy has just been approved. |
31420 | Could CRISPR cure HIV someday?
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. This either deactivates the gene or allows it to be removed and swapped for different DNA. Research groups believe this strategy could be effective in removing latent HIV infections, because it can target the viral DNA embedded in the genome, rather than only stopping replication.
Using CRISPR for HIV gene therapy has shown promise in several test-tube studies, a 2020 review in The Journal of Clinical Investigation notes. Various groups have been working to bring the therapies from test tubes to human patients — and that brings us to EBT-101.
Related: The world's 1st CRISPR therapy has just been approved. Here's everything you need to know
HIV infects immune cells in the body. |
31421 | Could CRISPR cure HIV someday?
CRISPR works by targeting and cleaving specific sequences of DNA from the genome; a "guide" leads CRISPR's famous "molecular scissors" to the targeted gene. This either deactivates the gene or allows it to be removed and swapped for different DNA. Research groups believe this strategy could be effective in removing latent HIV infections, because it can target the viral DNA embedded in the genome, rather than only stopping replication.
Using CRISPR for HIV gene therapy has shown promise in several test-tube studies, a 2020 review in The Journal of Clinical Investigation notes. Various groups have been working to bring the therapies from test tubes to human patients — and that brings us to EBT-101.
Related: The world's 1st CRISPR therapy has just been approved. Here's everything you need to know
HIV infects immune cells in the body. (Image credit: KATERYNA KON/SCIENCE PHOTO LIBRARY via Getty Images)
All about EBT-101
According to a recent presentation at the annual meeting of the European Society for Gene and Cell Therapy in Brussels, EBT-101 uses multiple guides to target multiple sites in the genome and snip out large sections of latently integrated HIV DNA. |
31422 | Could CRISPR cure HIV someday?
Using CRISPR for HIV gene therapy has shown promise in several test-tube studies, a 2020 review in The Journal of Clinical Investigation notes. Various groups have been working to bring the therapies from test tubes to human patients — and that brings us to EBT-101.
Related: The world's 1st CRISPR therapy has just been approved. Here's everything you need to know
HIV infects immune cells in the body. (Image credit: KATERYNA KON/SCIENCE PHOTO LIBRARY via Getty Images)
All about EBT-101
According to a recent presentation at the annual meeting of the European Society for Gene and Cell Therapy in Brussels, EBT-101 uses multiple guides to target multiple sites in the genome and snip out large sections of latently integrated HIV DNA. This stops HIV from replicating. |
31423 | Could CRISPR cure HIV someday?
Using CRISPR for HIV gene therapy has shown promise in several test-tube studies, a 2020 review in The Journal of Clinical Investigation notes. Various groups have been working to bring the therapies from test tubes to human patients — and that brings us to EBT-101.
Related: The world's 1st CRISPR therapy has just been approved. Here's everything you need to know
HIV infects immune cells in the body. (Image credit: KATERYNA KON/SCIENCE PHOTO LIBRARY via Getty Images)
All about EBT-101
According to a recent presentation at the annual meeting of the European Society for Gene and Cell Therapy in Brussels, EBT-101 uses multiple guides to target multiple sites in the genome and snip out large sections of latently integrated HIV DNA. This stops HIV from replicating.
Kamel Kahlili , a professor of neurovirology and gene editing at Temple University and co-founder of Excision BioTherapeutics , has been working with the company to develop EBT-101 for a decade. |
31424 | Could CRISPR cure HIV someday?
Various groups have been working to bring the therapies from test tubes to human patients — and that brings us to EBT-101.
Related: The world's 1st CRISPR therapy has just been approved. Here's everything you need to know
HIV infects immune cells in the body. (Image credit: KATERYNA KON/SCIENCE PHOTO LIBRARY via Getty Images)
All about EBT-101
According to a recent presentation at the annual meeting of the European Society for Gene and Cell Therapy in Brussels, EBT-101 uses multiple guides to target multiple sites in the genome and snip out large sections of latently integrated HIV DNA. This stops HIV from replicating.
Kamel Kahlili , a professor of neurovirology and gene editing at Temple University and co-founder of Excision BioTherapeutics , has been working with the company to develop EBT-101 for a decade. In 2020 and 2023 , Khalili and his team published reports that showed that EBT-100, a precursor to EBT-101, safely targeted and removed HIV DNA in infected primates. |
31425 | Could CRISPR cure HIV someday?
Here's everything you need to know
HIV infects immune cells in the body. (Image credit: KATERYNA KON/SCIENCE PHOTO LIBRARY via Getty Images)
All about EBT-101
According to a recent presentation at the annual meeting of the European Society for Gene and Cell Therapy in Brussels, EBT-101 uses multiple guides to target multiple sites in the genome and snip out large sections of latently integrated HIV DNA. This stops HIV from replicating.
Kamel Kahlili , a professor of neurovirology and gene editing at Temple University and co-founder of Excision BioTherapeutics , has been working with the company to develop EBT-101 for a decade. In 2020 and 2023 , Khalili and his team published reports that showed that EBT-100, a precursor to EBT-101, safely targeted and removed HIV DNA in infected primates.
Now, they're testing their EBT-101 targeting strategy in humans in an early-stage clinical trial that primarily focuses on the safety of the treatment. |
31426 | Could CRISPR cure HIV someday?
This stops HIV from replicating.
Kamel Kahlili , a professor of neurovirology and gene editing at Temple University and co-founder of Excision BioTherapeutics , has been working with the company to develop EBT-101 for a decade. In 2020 and 2023 , Khalili and his team published reports that showed that EBT-100, a precursor to EBT-101, safely targeted and removed HIV DNA in infected primates.
Now, they're testing their EBT-101 targeting strategy in humans in an early-stage clinical trial that primarily focuses on the safety of the treatment. Initial results from three treated patients showed no toxic effects or serious adverse events. All of the patients' HIV is currently suppressed with cART.
"The initial safety results are promising because no adverse outcomes have been observed to date," said Hope, whose lab studies the mechanisms behind HIV infections. "But more time is needed to be sure because of the way genetic off-target mutations can take years to manifest into complications," he added. |
31427 | Could CRISPR cure HIV someday?
In 2020 and 2023 , Khalili and his team published reports that showed that EBT-100, a precursor to EBT-101, safely targeted and removed HIV DNA in infected primates.
Now, they're testing their EBT-101 targeting strategy in humans in an early-stage clinical trial that primarily focuses on the safety of the treatment. Initial results from three treated patients showed no toxic effects or serious adverse events. All of the patients' HIV is currently suppressed with cART.
"The initial safety results are promising because no adverse outcomes have been observed to date," said Hope, whose lab studies the mechanisms behind HIV infections. "But more time is needed to be sure because of the way genetic off-target mutations can take years to manifest into complications," he added.
Off-target effects of CRISPR refer to when the CRISPR molecule alters DNA at sites other than those targeted. |
31428 | Could CRISPR cure HIV someday?
In 2020 and 2023 , Khalili and his team published reports that showed that EBT-100, a precursor to EBT-101, safely targeted and removed HIV DNA in infected primates.
Now, they're testing their EBT-101 targeting strategy in humans in an early-stage clinical trial that primarily focuses on the safety of the treatment. Initial results from three treated patients showed no toxic effects or serious adverse events. All of the patients' HIV is currently suppressed with cART.
"The initial safety results are promising because no adverse outcomes have been observed to date," said Hope, whose lab studies the mechanisms behind HIV infections. "But more time is needed to be sure because of the way genetic off-target mutations can take years to manifest into complications," he added.
Off-target effects of CRISPR refer to when the CRISPR molecule alters DNA at sites other than those targeted. These unintended snips have long been a worry for researchers designing CRISPR treatments, so they'll be something to watch for with EBT-101, especially since the treatment targets multiple sites in the genome . |
31429 | Could CRISPR cure HIV someday?
Now, they're testing their EBT-101 targeting strategy in humans in an early-stage clinical trial that primarily focuses on the safety of the treatment. Initial results from three treated patients showed no toxic effects or serious adverse events. All of the patients' HIV is currently suppressed with cART.
"The initial safety results are promising because no adverse outcomes have been observed to date," said Hope, whose lab studies the mechanisms behind HIV infections. "But more time is needed to be sure because of the way genetic off-target mutations can take years to manifest into complications," he added.
Off-target effects of CRISPR refer to when the CRISPR molecule alters DNA at sites other than those targeted. These unintended snips have long been a worry for researchers designing CRISPR treatments, so they'll be something to watch for with EBT-101, especially since the treatment targets multiple sites in the genome .
Additionally, experts told Live Science that even though the ongoing trial hints that the therapy has a positive safety profile, we still don't know whether one dose can effectively target latent HIV cells and whether it can control HIV in humans. |
31430 | Could CRISPR cure HIV someday?
Initial results from three treated patients showed no toxic effects or serious adverse events. All of the patients' HIV is currently suppressed with cART.
"The initial safety results are promising because no adverse outcomes have been observed to date," said Hope, whose lab studies the mechanisms behind HIV infections. "But more time is needed to be sure because of the way genetic off-target mutations can take years to manifest into complications," he added.
Off-target effects of CRISPR refer to when the CRISPR molecule alters DNA at sites other than those targeted. These unintended snips have long been a worry for researchers designing CRISPR treatments, so they'll be something to watch for with EBT-101, especially since the treatment targets multiple sites in the genome .
Additionally, experts told Live Science that even though the ongoing trial hints that the therapy has a positive safety profile, we still don't know whether one dose can effectively target latent HIV cells and whether it can control HIV in humans.
"It is crucial to approach this with caution," Herrera-Carrillo said. |
31431 | Could CRISPR cure HIV someday?
All of the patients' HIV is currently suppressed with cART.
"The initial safety results are promising because no adverse outcomes have been observed to date," said Hope, whose lab studies the mechanisms behind HIV infections. "But more time is needed to be sure because of the way genetic off-target mutations can take years to manifest into complications," he added.
Off-target effects of CRISPR refer to when the CRISPR molecule alters DNA at sites other than those targeted. These unintended snips have long been a worry for researchers designing CRISPR treatments, so they'll be something to watch for with EBT-101, especially since the treatment targets multiple sites in the genome .
Additionally, experts told Live Science that even though the ongoing trial hints that the therapy has a positive safety profile, we still don't know whether one dose can effectively target latent HIV cells and whether it can control HIV in humans.
"It is crucial to approach this with caution," Herrera-Carrillo said. "While optimism about being on the right track is justified, it's important to recognize the substantial work that still needs to be done." |
31432 | Could CRISPR cure HIV someday?
"But more time is needed to be sure because of the way genetic off-target mutations can take years to manifest into complications," he added.
Off-target effects of CRISPR refer to when the CRISPR molecule alters DNA at sites other than those targeted. These unintended snips have long been a worry for researchers designing CRISPR treatments, so they'll be something to watch for with EBT-101, especially since the treatment targets multiple sites in the genome .
Additionally, experts told Live Science that even though the ongoing trial hints that the therapy has a positive safety profile, we still don't know whether one dose can effectively target latent HIV cells and whether it can control HIV in humans.
"It is crucial to approach this with caution," Herrera-Carrillo said. "While optimism about being on the right track is justified, it's important to recognize the substantial work that still needs to be done."
The clinical trial will next test additional doses of EBT-101 for safety and then determine whether the virus stays suppressed when patients are taken off cART. |
31433 | Could CRISPR cure HIV someday?
Off-target effects of CRISPR refer to when the CRISPR molecule alters DNA at sites other than those targeted. These unintended snips have long been a worry for researchers designing CRISPR treatments, so they'll be something to watch for with EBT-101, especially since the treatment targets multiple sites in the genome .
Additionally, experts told Live Science that even though the ongoing trial hints that the therapy has a positive safety profile, we still don't know whether one dose can effectively target latent HIV cells and whether it can control HIV in humans.
"It is crucial to approach this with caution," Herrera-Carrillo said. "While optimism about being on the right track is justified, it's important to recognize the substantial work that still needs to be done."
The clinical trial will next test additional doses of EBT-101 for safety and then determine whether the virus stays suppressed when patients are taken off cART. cART therapies pump the brakes on HIV replication, so the only way to determine whether the latent cell reservoirs have been disabled is to temporarily lift those brakes. |
31434 | Could CRISPR cure HIV someday?
These unintended snips have long been a worry for researchers designing CRISPR treatments, so they'll be something to watch for with EBT-101, especially since the treatment targets multiple sites in the genome .
Additionally, experts told Live Science that even though the ongoing trial hints that the therapy has a positive safety profile, we still don't know whether one dose can effectively target latent HIV cells and whether it can control HIV in humans.
"It is crucial to approach this with caution," Herrera-Carrillo said. "While optimism about being on the right track is justified, it's important to recognize the substantial work that still needs to be done."
The clinical trial will next test additional doses of EBT-101 for safety and then determine whether the virus stays suppressed when patients are taken off cART. cART therapies pump the brakes on HIV replication, so the only way to determine whether the latent cell reservoirs have been disabled is to temporarily lift those brakes.
Interruptions to HIV treatment are necessary to determine whether a patient is in remission — as has occurred in the few people cured of HIV — but in general, purposeful treatment interruptions have been debated due to their inherent risks. |
31435 | Could CRISPR cure HIV someday?
Additionally, experts told Live Science that even though the ongoing trial hints that the therapy has a positive safety profile, we still don't know whether one dose can effectively target latent HIV cells and whether it can control HIV in humans.
"It is crucial to approach this with caution," Herrera-Carrillo said. "While optimism about being on the right track is justified, it's important to recognize the substantial work that still needs to be done."
The clinical trial will next test additional doses of EBT-101 for safety and then determine whether the virus stays suppressed when patients are taken off cART. cART therapies pump the brakes on HIV replication, so the only way to determine whether the latent cell reservoirs have been disabled is to temporarily lift those brakes.
Interruptions to HIV treatment are necessary to determine whether a patient is in remission — as has occurred in the few people cured of HIV — but in general, purposeful treatment interruptions have been debated due to their inherent risks.
Following these tests, EBT-101 trial participants will be enrolled in a long-term follow-up study for 15 years following their initial dose to check for long-term adverse effects. |
31436 | Could CRISPR cure HIV someday?
"It is crucial to approach this with caution," Herrera-Carrillo said. "While optimism about being on the right track is justified, it's important to recognize the substantial work that still needs to be done."
The clinical trial will next test additional doses of EBT-101 for safety and then determine whether the virus stays suppressed when patients are taken off cART. cART therapies pump the brakes on HIV replication, so the only way to determine whether the latent cell reservoirs have been disabled is to temporarily lift those brakes.
Interruptions to HIV treatment are necessary to determine whether a patient is in remission — as has occurred in the few people cured of HIV — but in general, purposeful treatment interruptions have been debated due to their inherent risks.
Following these tests, EBT-101 trial participants will be enrolled in a long-term follow-up study for 15 years following their initial dose to check for long-term adverse effects. So the data is on its way, but will take years to arrive. |
31437 | Here are the shipping deadlines to get your holiday gifts on time
The same thing happens year after year. Things get busy with work, school, and life in general until you’re suddenly up against the clock as you race your gifts to your local post office, FedEx store, or UPS location. We’ve all been there, but we’d like to be of some help as you plan your next move and begin sending out your holiday packages.
If you plan on sending your gifts via traditional mail, what follows are the upcoming domestic shipping deadlines for various retailers and shipment carriers so you can ensure that your packages arrive before Christmas, Kwanzaa, or whatever holiday it is you celebrate this time of year. Hopefully, it’ll help you avoid some holiday stress, if at all possible. |
31438 | Here are the shipping deadlines to get your holiday gifts on time
The same thing happens year after year. Things get busy with work, school, and life in general until you’re suddenly up against the clock as you race your gifts to your local post office, FedEx store, or UPS location. We’ve all been there, but we’d like to be of some help as you plan your next move and begin sending out your holiday packages.
If you plan on sending your gifts via traditional mail, what follows are the upcoming domestic shipping deadlines for various retailers and shipment carriers so you can ensure that your packages arrive before Christmas, Kwanzaa, or whatever holiday it is you celebrate this time of year. Hopefully, it’ll help you avoid some holiday stress, if at all possible.
UPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th UPS 3 Day Select December 20th UPS 2nd Day Air December 21st UPS Next Day Air
With UPS, you have until Thursday, December 21st, to ship via Next Day Air and have your package arrive by Friday, December 22nd. |
31439 | Here are the shipping deadlines to get your holiday gifts on time
We’ve all been there, but we’d like to be of some help as you plan your next move and begin sending out your holiday packages.
If you plan on sending your gifts via traditional mail, what follows are the upcoming domestic shipping deadlines for various retailers and shipment carriers so you can ensure that your packages arrive before Christmas, Kwanzaa, or whatever holiday it is you celebrate this time of year. Hopefully, it’ll help you avoid some holiday stress, if at all possible.
UPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th UPS 3 Day Select December 20th UPS 2nd Day Air December 21st UPS Next Day Air
With UPS, you have until Thursday, December 21st, to ship via Next Day Air and have your package arrive by Friday, December 22nd. Packages shipped via Next Day Air after Thursday won’t arrive until after Christmas. |
31440 | Here are the shipping deadlines to get your holiday gifts on time
We’ve all been there, but we’d like to be of some help as you plan your next move and begin sending out your holiday packages.
If you plan on sending your gifts via traditional mail, what follows are the upcoming domestic shipping deadlines for various retailers and shipment carriers so you can ensure that your packages arrive before Christmas, Kwanzaa, or whatever holiday it is you celebrate this time of year. Hopefully, it’ll help you avoid some holiday stress, if at all possible.
UPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th UPS 3 Day Select December 20th UPS 2nd Day Air December 21st UPS Next Day Air
With UPS, you have until Thursday, December 21st, to ship via Next Day Air and have your package arrive by Friday, December 22nd. Packages shipped via Next Day Air after Thursday won’t arrive until after Christmas. Wednesday, December 20th, is the last day to ship via 2nd Day Air if you want your package to arrive by Friday, December 22nd. |
31441 | Here are the shipping deadlines to get your holiday gifts on time
If you plan on sending your gifts via traditional mail, what follows are the upcoming domestic shipping deadlines for various retailers and shipment carriers so you can ensure that your packages arrive before Christmas, Kwanzaa, or whatever holiday it is you celebrate this time of year. Hopefully, it’ll help you avoid some holiday stress, if at all possible.
UPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th UPS 3 Day Select December 20th UPS 2nd Day Air December 21st UPS Next Day Air
With UPS, you have until Thursday, December 21st, to ship via Next Day Air and have your package arrive by Friday, December 22nd. Packages shipped via Next Day Air after Thursday won’t arrive until after Christmas. Wednesday, December 20th, is the last day to ship via 2nd Day Air if you want your package to arrive by Friday, December 22nd. You can opt for UPS’s 3 Day Select option until Tuesday, December 19th, to have it arrive by the 22nd. |
31442 | Here are the shipping deadlines to get your holiday gifts on time
Hopefully, it’ll help you avoid some holiday stress, if at all possible.
UPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th UPS 3 Day Select December 20th UPS 2nd Day Air December 21st UPS Next Day Air
With UPS, you have until Thursday, December 21st, to ship via Next Day Air and have your package arrive by Friday, December 22nd. Packages shipped via Next Day Air after Thursday won’t arrive until after Christmas. Wednesday, December 20th, is the last day to ship via 2nd Day Air if you want your package to arrive by Friday, December 22nd. You can opt for UPS’s 3 Day Select option until Tuesday, December 19th, to have it arrive by the 22nd. Before then, you can select the normal pickup and delivery service to get your packages where they need to be on time. |
31443 | Here are the shipping deadlines to get your holiday gifts on time
Hopefully, it’ll help you avoid some holiday stress, if at all possible.
UPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th UPS 3 Day Select December 20th UPS 2nd Day Air December 21st UPS Next Day Air
With UPS, you have until Thursday, December 21st, to ship via Next Day Air and have your package arrive by Friday, December 22nd. Packages shipped via Next Day Air after Thursday won’t arrive until after Christmas. Wednesday, December 20th, is the last day to ship via 2nd Day Air if you want your package to arrive by Friday, December 22nd. You can opt for UPS’s 3 Day Select option until Tuesday, December 19th, to have it arrive by the 22nd. Before then, you can select the normal pickup and delivery service to get your packages where they need to be on time.
FedEx 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th FedEx Express Saver December 20th FedEx 2Day and 2Day A.M. |
31444 | Here are the shipping deadlines to get your holiday gifts on time
Packages shipped via Next Day Air after Thursday won’t arrive until after Christmas. Wednesday, December 20th, is the last day to ship via 2nd Day Air if you want your package to arrive by Friday, December 22nd. You can opt for UPS’s 3 Day Select option until Tuesday, December 19th, to have it arrive by the 22nd. Before then, you can select the normal pickup and delivery service to get your packages where they need to be on time.
FedEx 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th FedEx Express Saver December 20th FedEx 2Day and 2Day A.M. December 22nd FedEx SameDay
FedEx’s same-day shipping can get your package where it needs to be by Friday, December 22nd. That’s the last day that FedEx can guarantee that your package will arrive by Christmas. |
31445 | Here are the shipping deadlines to get your holiday gifts on time
Packages shipped via Next Day Air after Thursday won’t arrive until after Christmas. Wednesday, December 20th, is the last day to ship via 2nd Day Air if you want your package to arrive by Friday, December 22nd. You can opt for UPS’s 3 Day Select option until Tuesday, December 19th, to have it arrive by the 22nd. Before then, you can select the normal pickup and delivery service to get your packages where they need to be on time.
FedEx 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th FedEx Express Saver December 20th FedEx 2Day and 2Day A.M. December 22nd FedEx SameDay
FedEx’s same-day shipping can get your package where it needs to be by Friday, December 22nd. That’s the last day that FedEx can guarantee that your package will arrive by Christmas. If you ship it by Wednesday, December 20th, you can opt for the two-day shipping method. |
31446 | Here are the shipping deadlines to get your holiday gifts on time
You can opt for UPS’s 3 Day Select option until Tuesday, December 19th, to have it arrive by the 22nd. Before then, you can select the normal pickup and delivery service to get your packages where they need to be on time.
FedEx 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th FedEx Express Saver December 20th FedEx 2Day and 2Day A.M. December 22nd FedEx SameDay
FedEx’s same-day shipping can get your package where it needs to be by Friday, December 22nd. That’s the last day that FedEx can guarantee that your package will arrive by Christmas. If you ship it by Wednesday, December 20th, you can opt for the two-day shipping method. If you manage to get it to FedEx by Tuesday, December 19th, you can go the Express Saver route and (hopefully) pay a reasonable fee for shipping. |
31447 | Here are the shipping deadlines to get your holiday gifts on time
Before then, you can select the normal pickup and delivery service to get your packages where they need to be on time.
FedEx 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 19th FedEx Express Saver December 20th FedEx 2Day and 2Day A.M. December 22nd FedEx SameDay
FedEx’s same-day shipping can get your package where it needs to be by Friday, December 22nd. That’s the last day that FedEx can guarantee that your package will arrive by Christmas. If you ship it by Wednesday, December 20th, you can opt for the two-day shipping method. If you manage to get it to FedEx by Tuesday, December 19th, you can go the Express Saver route and (hopefully) pay a reasonable fee for shipping.
USPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 20th First-Class Mail December 20th USPS Ground Advantage December 21st Priority Mail December 21st Priority Mail Express
Thursday, December 21st, is the final day to send packages (and have them arrive by Christmas Eve) through USPS via its Priority Mail Express service. |
31448 | Here are the shipping deadlines to get your holiday gifts on time
December 22nd FedEx SameDay
FedEx’s same-day shipping can get your package where it needs to be by Friday, December 22nd. That’s the last day that FedEx can guarantee that your package will arrive by Christmas. If you ship it by Wednesday, December 20th, you can opt for the two-day shipping method. If you manage to get it to FedEx by Tuesday, December 19th, you can go the Express Saver route and (hopefully) pay a reasonable fee for shipping.
USPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 20th First-Class Mail December 20th USPS Ground Advantage December 21st Priority Mail December 21st Priority Mail Express
Thursday, December 21st, is the final day to send packages (and have them arrive by Christmas Eve) through USPS via its Priority Mail Express service. You can also get packages delivered by December 23rd via Priority Mail. |
31449 | Here are the shipping deadlines to get your holiday gifts on time
That’s the last day that FedEx can guarantee that your package will arrive by Christmas. If you ship it by Wednesday, December 20th, you can opt for the two-day shipping method. If you manage to get it to FedEx by Tuesday, December 19th, you can go the Express Saver route and (hopefully) pay a reasonable fee for shipping.
USPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 20th First-Class Mail December 20th USPS Ground Advantage December 21st Priority Mail December 21st Priority Mail Express
Thursday, December 21st, is the final day to send packages (and have them arrive by Christmas Eve) through USPS via its Priority Mail Express service. You can also get packages delivered by December 23rd via Priority Mail. First-Class Mail packages and those you intend to send via USPS Ground Advantage, meanwhile, must be sent by Wednesday, December 20th, to arrive in time. |
31450 | Here are the shipping deadlines to get your holiday gifts on time
If you ship it by Wednesday, December 20th, you can opt for the two-day shipping method. If you manage to get it to FedEx by Tuesday, December 19th, you can go the Express Saver route and (hopefully) pay a reasonable fee for shipping.
USPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 20th First-Class Mail December 20th USPS Ground Advantage December 21st Priority Mail December 21st Priority Mail Express
Thursday, December 21st, is the final day to send packages (and have them arrive by Christmas Eve) through USPS via its Priority Mail Express service. You can also get packages delivered by December 23rd via Priority Mail. First-Class Mail packages and those you intend to send via USPS Ground Advantage, meanwhile, must be sent by Wednesday, December 20th, to arrive in time.
Illustration by Alex Castro / The Verge
If you subscribe to Amazon Prime and live in an eligible ZIP code in the US, you can get Same-Day Delivery on certain items through December 24th. |
31451 | Here are the shipping deadlines to get your holiday gifts on time
USPS 2023 Holiday Shipping Deadlines Final day to ship Ships via this service December 20th First-Class Mail December 20th USPS Ground Advantage December 21st Priority Mail December 21st Priority Mail Express
Thursday, December 21st, is the final day to send packages (and have them arrive by Christmas Eve) through USPS via its Priority Mail Express service. You can also get packages delivered by December 23rd via Priority Mail. First-Class Mail packages and those you intend to send via USPS Ground Advantage, meanwhile, must be sent by Wednesday, December 20th, to arrive in time.
Illustration by Alex Castro / The Verge
If you subscribe to Amazon Prime and live in an eligible ZIP code in the US, you can get Same-Day Delivery on certain items through December 24th. You’ll need to meet the “minimum threshold” of eligible items in your cart, however, which can vary by location (see here for more details). In LA, for example, the threshold is over $25. |
31452 | Here are the shipping deadlines to get your holiday gifts on time
You can also get packages delivered by December 23rd via Priority Mail. First-Class Mail packages and those you intend to send via USPS Ground Advantage, meanwhile, must be sent by Wednesday, December 20th, to arrive in time.
Illustration by Alex Castro / The Verge
If you subscribe to Amazon Prime and live in an eligible ZIP code in the US, you can get Same-Day Delivery on certain items through December 24th. You’ll need to meet the “minimum threshold” of eligible items in your cart, however, which can vary by location (see here for more details). In LA, for example, the threshold is over $25.
Prime members can get One-Day Delivery for eligible products through December 23rd with no minimum purchase amount or Two-Day Delivery through December 22nd.
If you’re a Prime member in select US cities, you can take advantage of two-hour grocery delivery through December 24th. |
31453 | Here are the shipping deadlines to get your holiday gifts on time
You can also get packages delivered by December 23rd via Priority Mail. First-Class Mail packages and those you intend to send via USPS Ground Advantage, meanwhile, must be sent by Wednesday, December 20th, to arrive in time.
Illustration by Alex Castro / The Verge
If you subscribe to Amazon Prime and live in an eligible ZIP code in the US, you can get Same-Day Delivery on certain items through December 24th. You’ll need to meet the “minimum threshold” of eligible items in your cart, however, which can vary by location (see here for more details). In LA, for example, the threshold is over $25.
Prime members can get One-Day Delivery for eligible products through December 23rd with no minimum purchase amount or Two-Day Delivery through December 22nd.
If you’re a Prime member in select US cities, you can take advantage of two-hour grocery delivery through December 24th.
Shipping times and prices may vary depending on the product type, size, and whether it’s shipping directly from Amazon or a third-party seller, so make sure to check the expected arrival date at checkout, then choose accordingly. |
31454 | Here are the shipping deadlines to get your holiday gifts on time
Illustration by Alex Castro / The Verge
If you subscribe to Amazon Prime and live in an eligible ZIP code in the US, you can get Same-Day Delivery on certain items through December 24th. You’ll need to meet the “minimum threshold” of eligible items in your cart, however, which can vary by location (see here for more details). In LA, for example, the threshold is over $25.
Prime members can get One-Day Delivery for eligible products through December 23rd with no minimum purchase amount or Two-Day Delivery through December 22nd.
If you’re a Prime member in select US cities, you can take advantage of two-hour grocery delivery through December 24th.
Shipping times and prices may vary depending on the product type, size, and whether it’s shipping directly from Amazon or a third-party seller, so make sure to check the expected arrival date at checkout, then choose accordingly.
Illustration by Kristen Radtke
Best Buy 2023 deadlines
If you’re a My Best Buy Plus and My Best Buy Total subscriber, you can get free two-day shipping, and there’s no order minimum. |
31455 | Here are the shipping deadlines to get your holiday gifts on time
You’ll need to meet the “minimum threshold” of eligible items in your cart, however, which can vary by location (see here for more details). In LA, for example, the threshold is over $25.
Prime members can get One-Day Delivery for eligible products through December 23rd with no minimum purchase amount or Two-Day Delivery through December 22nd.
If you’re a Prime member in select US cities, you can take advantage of two-hour grocery delivery through December 24th.
Shipping times and prices may vary depending on the product type, size, and whether it’s shipping directly from Amazon or a third-party seller, so make sure to check the expected arrival date at checkout, then choose accordingly.
Illustration by Kristen Radtke
Best Buy 2023 deadlines
If you’re a My Best Buy Plus and My Best Buy Total subscriber, you can get free two-day shipping, and there’s no order minimum.
Other customers need to clear the $35 order threshold (before taxes but after coupons), and certain items are available for next-day and standard shipping. |
31456 | Here are the shipping deadlines to get your holiday gifts on time
In LA, for example, the threshold is over $25.
Prime members can get One-Day Delivery for eligible products through December 23rd with no minimum purchase amount or Two-Day Delivery through December 22nd.
If you’re a Prime member in select US cities, you can take advantage of two-hour grocery delivery through December 24th.
Shipping times and prices may vary depending on the product type, size, and whether it’s shipping directly from Amazon or a third-party seller, so make sure to check the expected arrival date at checkout, then choose accordingly.
Illustration by Kristen Radtke
Best Buy 2023 deadlines
If you’re a My Best Buy Plus and My Best Buy Total subscriber, you can get free two-day shipping, and there’s no order minimum.
Other customers need to clear the $35 order threshold (before taxes but after coupons), and certain items are available for next-day and standard shipping.
December 21st at 11:30AM ET is the cutoff date for free shipping if you want your package to arrive by December 23rd. |
31457 | Here are the shipping deadlines to get your holiday gifts on time
If you’re a Prime member in select US cities, you can take advantage of two-hour grocery delivery through December 24th.
Shipping times and prices may vary depending on the product type, size, and whether it’s shipping directly from Amazon or a third-party seller, so make sure to check the expected arrival date at checkout, then choose accordingly.
Illustration by Kristen Radtke
Best Buy 2023 deadlines
If you’re a My Best Buy Plus and My Best Buy Total subscriber, you can get free two-day shipping, and there’s no order minimum.
Other customers need to clear the $35 order threshold (before taxes but after coupons), and certain items are available for next-day and standard shipping.
December 21st at 11:30AM ET is the cutoff date for free shipping if you want your package to arrive by December 23rd.
Free next-day delivery is available on select items through December 23rd.
You can get free same-day delivery if you order your package on December 23rd or December 24th. |
31458 | Here are the shipping deadlines to get your holiday gifts on time
Shipping times and prices may vary depending on the product type, size, and whether it’s shipping directly from Amazon or a third-party seller, so make sure to check the expected arrival date at checkout, then choose accordingly.
Illustration by Kristen Radtke
Best Buy 2023 deadlines
If you’re a My Best Buy Plus and My Best Buy Total subscriber, you can get free two-day shipping, and there’s no order minimum.
Other customers need to clear the $35 order threshold (before taxes but after coupons), and certain items are available for next-day and standard shipping.
December 21st at 11:30AM ET is the cutoff date for free shipping if you want your package to arrive by December 23rd.
Free next-day delivery is available on select items through December 23rd.
You can get free same-day delivery if you order your package on December 23rd or December 24th. You must place your order by 12PM local time for free same-day delivery by 7PM. |
31459 | Here are the shipping deadlines to get your holiday gifts on time
Illustration by Kristen Radtke
Best Buy 2023 deadlines
If you’re a My Best Buy Plus and My Best Buy Total subscriber, you can get free two-day shipping, and there’s no order minimum.
Other customers need to clear the $35 order threshold (before taxes but after coupons), and certain items are available for next-day and standard shipping.
December 21st at 11:30AM ET is the cutoff date for free shipping if you want your package to arrive by December 23rd.
Free next-day delivery is available on select items through December 23rd.
You can get free same-day delivery if you order your package on December 23rd or December 24th. You must place your order by 12PM local time for free same-day delivery by 7PM.
You can also order online by 5PM local time on Christmas Eve for an in-store pickup at 7PM.
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. |
31460 | Here are the shipping deadlines to get your holiday gifts on time
Other customers need to clear the $35 order threshold (before taxes but after coupons), and certain items are available for next-day and standard shipping.
December 21st at 11:30AM ET is the cutoff date for free shipping if you want your package to arrive by December 23rd.
Free next-day delivery is available on select items through December 23rd.
You can get free same-day delivery if you order your package on December 23rd or December 24th. You must place your order by 12PM local time for free same-day delivery by 7PM.
You can also order online by 5PM local time on Christmas Eve for an in-store pickup at 7PM.
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. Major appliances may take longer to be delivered at this point.
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. |
31461 | Here are the shipping deadlines to get your holiday gifts on time
December 21st at 11:30AM ET is the cutoff date for free shipping if you want your package to arrive by December 23rd.
Free next-day delivery is available on select items through December 23rd.
You can get free same-day delivery if you order your package on December 23rd or December 24th. You must place your order by 12PM local time for free same-day delivery by 7PM.
You can also order online by 5PM local time on Christmas Eve for an in-store pickup at 7PM.
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. Major appliances may take longer to be delivered at this point.
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas. |
31462 | Here are the shipping deadlines to get your holiday gifts on time
Free next-day delivery is available on select items through December 23rd.
You can get free same-day delivery if you order your package on December 23rd or December 24th. You must place your order by 12PM local time for free same-day delivery by 7PM.
You can also order online by 5PM local time on Christmas Eve for an in-store pickup at 7PM.
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. Major appliances may take longer to be delivered at this point.
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. |
31463 | Here are the shipping deadlines to get your holiday gifts on time
You can get free same-day delivery if you order your package on December 23rd or December 24th. You must place your order by 12PM local time for free same-day delivery by 7PM.
You can also order online by 5PM local time on Christmas Eve for an in-store pickup at 7PM.
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. Major appliances may take longer to be delivered at this point.
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item. |
31464 | Here are the shipping deadlines to get your holiday gifts on time
You must place your order by 12PM local time for free same-day delivery by 7PM.
You can also order online by 5PM local time on Christmas Eve for an in-store pickup at 7PM.
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. Major appliances may take longer to be delivered at this point.
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item.
The retailer offers in-store pickup through December 24th, depending on availability, as well as same-day delivery on December 24th. |
31465 | Here are the shipping deadlines to get your holiday gifts on time
You can also order online by 5PM local time on Christmas Eve for an in-store pickup at 7PM.
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. Major appliances may take longer to be delivered at this point.
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item.
The retailer offers in-store pickup through December 24th, depending on availability, as well as same-day delivery on December 24th. Same-day pickup is available on orders made by 12PM local time. |
31466 | Here are the shipping deadlines to get your holiday gifts on time
Best Buy’s shipment arrival dates may vary depending on the kind of item that you’re getting. Major appliances may take longer to be delivered at this point.
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item.
The retailer offers in-store pickup through December 24th, depending on availability, as well as same-day delivery on December 24th. Same-day pickup is available on orders made by 12PM local time.
You can also have the package delivered to you in less than two hours on Christmas Eve if you order by 12PM local time and pay a $10 Express Delivery fee. |
31467 | Here are the shipping deadlines to get your holiday gifts on time
Illustration by Kristen Radtke
Walmart offers two-day shipping on items sold directly from Walmart, with orders over $35 shipping for free. You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item.
The retailer offers in-store pickup through December 24th, depending on availability, as well as same-day delivery on December 24th. Same-day pickup is available on orders made by 12PM local time.
You can also have the package delivered to you in less than two hours on Christmas Eve if you order by 12PM local time and pay a $10 Express Delivery fee. Note that Walmart Plus members also get one Express Delivery free during the month of December. |
31468 | Here are the shipping deadlines to get your holiday gifts on time
You must place orders by 2PM local time on December 21st to receive the package in time for Christmas, however. Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item.
The retailer offers in-store pickup through December 24th, depending on availability, as well as same-day delivery on December 24th. Same-day pickup is available on orders made by 12PM local time.
You can also have the package delivered to you in less than two hours on Christmas Eve if you order by 12PM local time and pay a $10 Express Delivery fee. Note that Walmart Plus members also get one Express Delivery free during the month of December.
Illustration by Kristen Radtke
Both same-day delivery and in-store pickup are available to you if you place an order by 6PM local time on Christmas Eve. |
31469 | Here are the shipping deadlines to get your holiday gifts on time
Next-day shipping is also available in some areas.
Walmart also offers free next-day and two-day shipping to Walmart Plus subscribers with no order minimum. However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item.
The retailer offers in-store pickup through December 24th, depending on availability, as well as same-day delivery on December 24th. Same-day pickup is available on orders made by 12PM local time.
You can also have the package delivered to you in less than two hours on Christmas Eve if you order by 12PM local time and pay a $10 Express Delivery fee. Note that Walmart Plus members also get one Express Delivery free during the month of December.
Illustration by Kristen Radtke
Both same-day delivery and in-store pickup are available to you if you place an order by 6PM local time on Christmas Eve. It helps to choose your desired location as “My store” in the upper-left corner of Target’s website, which will prompt it to automatically indicate if the item you’re purchasing is available for pickup nearby. |
31470 | Here are the shipping deadlines to get your holiday gifts on time
However, the arrival date of your package may vary depending on whether Walmart or a third-party seller is shipping your item.
The retailer offers in-store pickup through December 24th, depending on availability, as well as same-day delivery on December 24th. Same-day pickup is available on orders made by 12PM local time.
You can also have the package delivered to you in less than two hours on Christmas Eve if you order by 12PM local time and pay a $10 Express Delivery fee. Note that Walmart Plus members also get one Express Delivery free during the month of December.
Illustration by Kristen Radtke
Both same-day delivery and in-store pickup are available to you if you place an order by 6PM local time on Christmas Eve. It helps to choose your desired location as “My store” in the upper-left corner of Target’s website, which will prompt it to automatically indicate if the item you’re purchasing is available for pickup nearby.
You can also get packages within an hour on Christmas Eve (if you order before 4PM local time) with a service called Shipt. |
31471 | Here are the shipping deadlines to get your holiday gifts on time
Same-day pickup is available on orders made by 12PM local time.
You can also have the package delivered to you in less than two hours on Christmas Eve if you order by 12PM local time and pay a $10 Express Delivery fee. Note that Walmart Plus members also get one Express Delivery free during the month of December.
Illustration by Kristen Radtke
Both same-day delivery and in-store pickup are available to you if you place an order by 6PM local time on Christmas Eve. It helps to choose your desired location as “My store” in the upper-left corner of Target’s website, which will prompt it to automatically indicate if the item you’re purchasing is available for pickup nearby.
You can also get packages within an hour on Christmas Eve (if you order before 4PM local time) with a service called Shipt. An annual Shipt subscription provides unlimited deliveries on orders above $35 for $99 a year, though an annual membership is currently going for half off. |
31472 | Here are the shipping deadlines to get your holiday gifts on time
You can also have the package delivered to you in less than two hours on Christmas Eve if you order by 12PM local time and pay a $10 Express Delivery fee. Note that Walmart Plus members also get one Express Delivery free during the month of December.
Illustration by Kristen Radtke
Both same-day delivery and in-store pickup are available to you if you place an order by 6PM local time on Christmas Eve. It helps to choose your desired location as “My store” in the upper-left corner of Target’s website, which will prompt it to automatically indicate if the item you’re purchasing is available for pickup nearby.
You can also get packages within an hour on Christmas Eve (if you order before 4PM local time) with a service called Shipt. An annual Shipt subscription provides unlimited deliveries on orders above $35 for $99 a year, though an annual membership is currently going for half off. Alternatively, you can pay for same-day shipping with Shipt on a per-order basis via Target’s website. |
31473 | Here are the shipping deadlines to get your holiday gifts on time
Note that Walmart Plus members also get one Express Delivery free during the month of December.
Illustration by Kristen Radtke
Both same-day delivery and in-store pickup are available to you if you place an order by 6PM local time on Christmas Eve. It helps to choose your desired location as “My store” in the upper-left corner of Target’s website, which will prompt it to automatically indicate if the item you’re purchasing is available for pickup nearby.
You can also get packages within an hour on Christmas Eve (if you order before 4PM local time) with a service called Shipt. An annual Shipt subscription provides unlimited deliveries on orders above $35 for $99 a year, though an annual membership is currently going for half off. Alternatively, you can pay for same-day shipping with Shipt on a per-order basis via Target’s website. Shipping fees may vary depending on your location and the contents of the order. Here are answers to some frequently asked questions that might help. |
31474 | Here are the shipping deadlines to get your holiday gifts on time
Illustration by Kristen Radtke
Both same-day delivery and in-store pickup are available to you if you place an order by 6PM local time on Christmas Eve. It helps to choose your desired location as “My store” in the upper-left corner of Target’s website, which will prompt it to automatically indicate if the item you’re purchasing is available for pickup nearby.
You can also get packages within an hour on Christmas Eve (if you order before 4PM local time) with a service called Shipt. An annual Shipt subscription provides unlimited deliveries on orders above $35 for $99 a year, though an annual membership is currently going for half off. Alternatively, you can pay for same-day shipping with Shipt on a per-order basis via Target’s website. Shipping fees may vary depending on your location and the contents of the order. Here are answers to some frequently asked questions that might help.
Target RedCard credit card holders receive free two-day shipping on many items from the retailer’s website. |
31475 | Here are the shipping deadlines to get your holiday gifts on time
It helps to choose your desired location as “My store” in the upper-left corner of Target’s website, which will prompt it to automatically indicate if the item you’re purchasing is available for pickup nearby.
You can also get packages within an hour on Christmas Eve (if you order before 4PM local time) with a service called Shipt. An annual Shipt subscription provides unlimited deliveries on orders above $35 for $99 a year, though an annual membership is currently going for half off. Alternatively, you can pay for same-day shipping with Shipt on a per-order basis via Target’s website. Shipping fees may vary depending on your location and the contents of the order. Here are answers to some frequently asked questions that might help.
Target RedCard credit card holders receive free two-day shipping on many items from the retailer’s website.
Many (but not all) orders over $35 are eligible for free two-day shipping, even if you don’t have a Target RedCard. |
31476 | Here are the shipping deadlines to get your holiday gifts on time
You can also get packages within an hour on Christmas Eve (if you order before 4PM local time) with a service called Shipt. An annual Shipt subscription provides unlimited deliveries on orders above $35 for $99 a year, though an annual membership is currently going for half off. Alternatively, you can pay for same-day shipping with Shipt on a per-order basis via Target’s website. Shipping fees may vary depending on your location and the contents of the order. Here are answers to some frequently asked questions that might help.
Target RedCard credit card holders receive free two-day shipping on many items from the retailer’s website.
Many (but not all) orders over $35 are eligible for free two-day shipping, even if you don’t have a Target RedCard. It’s determined by the item’s location and your ZIP code.
Target stores will be open on Christmas Eve, though it’s wise to get pickup orders and same-day shipping orders in by December 23rd to be on the safe side. |
31477 | Here are the shipping deadlines to get your holiday gifts on time
An annual Shipt subscription provides unlimited deliveries on orders above $35 for $99 a year, though an annual membership is currently going for half off. Alternatively, you can pay for same-day shipping with Shipt on a per-order basis via Target’s website. Shipping fees may vary depending on your location and the contents of the order. Here are answers to some frequently asked questions that might help.
Target RedCard credit card holders receive free two-day shipping on many items from the retailer’s website.
Many (but not all) orders over $35 are eligible for free two-day shipping, even if you don’t have a Target RedCard. It’s determined by the item’s location and your ZIP code.
Target stores will be open on Christmas Eve, though it’s wise to get pickup orders and same-day shipping orders in by December 23rd to be on the safe side.
Similar to Walmart and Amazon, be aware that items at Target shipped or sold by third-party retailers can result in longer lead times. |
31478 | Here are the shipping deadlines to get your holiday gifts on time
Alternatively, you can pay for same-day shipping with Shipt on a per-order basis via Target’s website. Shipping fees may vary depending on your location and the contents of the order. Here are answers to some frequently asked questions that might help.
Target RedCard credit card holders receive free two-day shipping on many items from the retailer’s website.
Many (but not all) orders over $35 are eligible for free two-day shipping, even if you don’t have a Target RedCard. It’s determined by the item’s location and your ZIP code.
Target stores will be open on Christmas Eve, though it’s wise to get pickup orders and same-day shipping orders in by December 23rd to be on the safe side.
Similar to Walmart and Amazon, be aware that items at Target shipped or sold by third-party retailers can result in longer lead times. Product listings usually spell out your options for pickup, same-day delivery, and standard shipping — complete with estimated availability times — before you add them to your cart. |
31479 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
The Panthers entered the 2023 NFL season shrouded in optimism. The team had moved on from Matt Rhule, who proved to be an ineffective NFL coach, and added a potential franchise quarterback to the fold in Bryce Young.
The hope was that those moves would turn Carolina into a contender in the wide-open NFC South.
Instead, they find themselves not only at the bottom of the division but also sporting one of the worst records in the NFL at 1-7.
Young hasn't yet looked comfortable in the Panthers' offense, and he is coming off one of his worst games as a starter against the Colts. He threw three interceptions in that contest, including two pick-sixes to Kenny Moore in a 27-13 defeat.
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. |
31480 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
The Panthers entered the 2023 NFL season shrouded in optimism. The team had moved on from Matt Rhule, who proved to be an ineffective NFL coach, and added a potential franchise quarterback to the fold in Bryce Young.
The hope was that those moves would turn Carolina into a contender in the wide-open NFC South.
Instead, they find themselves not only at the bottom of the division but also sporting one of the worst records in the NFL at 1-7.
Young hasn't yet looked comfortable in the Panthers' offense, and he is coming off one of his worst games as a starter against the Colts. He threw three interceptions in that contest, including two pick-sixes to Kenny Moore in a 27-13 defeat.
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. |
31481 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
The team had moved on from Matt Rhule, who proved to be an ineffective NFL coach, and added a potential franchise quarterback to the fold in Bryce Young.
The hope was that those moves would turn Carolina into a contender in the wide-open NFC South.
Instead, they find themselves not only at the bottom of the division but also sporting one of the worst records in the NFL at 1-7.
Young hasn't yet looked comfortable in the Panthers' offense, and he is coming off one of his worst games as a starter against the Colts. He threw three interceptions in that contest, including two pick-sixes to Kenny Moore in a 27-13 defeat.
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL. |
31482 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
The hope was that those moves would turn Carolina into a contender in the wide-open NFC South.
Instead, they find themselves not only at the bottom of the division but also sporting one of the worst records in the NFL at 1-7.
Young hasn't yet looked comfortable in the Panthers' offense, and he is coming off one of his worst games as a starter against the Colts. He threw three interceptions in that contest, including two pick-sixes to Kenny Moore in a 27-13 defeat.
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. |
31483 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Instead, they find themselves not only at the bottom of the division but also sporting one of the worst records in the NFL at 1-7.
Young hasn't yet looked comfortable in the Panthers' offense, and he is coming off one of his worst games as a starter against the Colts. He threw three interceptions in that contest, including two pick-sixes to Kenny Moore in a 27-13 defeat.
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. That's the main reason that coach Frank Reich finds himself under fire for the team's performance. |
31484 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Young hasn't yet looked comfortable in the Panthers' offense, and he is coming off one of his worst games as a starter against the Colts. He threw three interceptions in that contest, including two pick-sixes to Kenny Moore in a 27-13 defeat.
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. That's the main reason that coach Frank Reich finds himself under fire for the team's performance.
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. |
31485 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Young hasn't yet looked comfortable in the Panthers' offense, and he is coming off one of his worst games as a starter against the Colts. He threw three interceptions in that contest, including two pick-sixes to Kenny Moore in a 27-13 defeat.
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. That's the main reason that coach Frank Reich finds himself under fire for the team's performance.
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season. |
31486 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
MORE: Full list of rookie quarterbacks to start an NFL game in 2023
The rest of the Panthers' offense hasn't been much better. Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. That's the main reason that coach Frank Reich finds himself under fire for the team's performance.
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season.
Will the Panthers fire Frank Reich? |
31487 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. That's the main reason that coach Frank Reich finds himself under fire for the team's performance.
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season.
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. |
31488 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Adam Thielen has looked rejuvenated in his new home, but running back Miles Sanders has been a bust acquisition. And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. That's the main reason that coach Frank Reich finds himself under fire for the team's performance.
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season.
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week. |
31489 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
And the team's offensive line has allowed 74 pressures on the season, good for the 10th-most in the NFL.
Indeed, Carolina's offense has been less-than-impressive in 2023. That's the main reason that coach Frank Reich finds himself under fire for the team's performance.
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season.
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week.
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina. |
31490 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
That's the main reason that coach Frank Reich finds himself under fire for the team's performance.
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season.
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week.
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. |
31491 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Reich already gave up play-calling to offensive coordinator Thomas Brown after the team's early-season struggles. Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season.
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week.
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. However, he detailed that owner David Tepper wouldn't be afraid to move on from Reich if he deemed it necessary for the success of his team. |
31492 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Now, there are questions about whether the team's lackluster offense — which averages the fifth-fewest yards (283.4) and sixth-fewest points (17.5) per game this season — could ultimately cause owner David Tepper to move on from Reich after just one season.
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week.
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. However, he detailed that owner David Tepper wouldn't be afraid to move on from Reich if he deemed it necessary for the success of his team.
"One thing about David Tepper: he's not very patient," Schefter said. |
31493 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week.
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. However, he detailed that owner David Tepper wouldn't be afraid to move on from Reich if he deemed it necessary for the success of his team.
"One thing about David Tepper: he's not very patient," Schefter said. "He's as successful as he is because of the way he's operated his business. And it's worked for him, basically at every level. He does what he wants. |
31494 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
Will the Panthers fire Frank Reich?
The Panthers aren't guaranteed to fire Reich even amid their poor season. But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week.
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. However, he detailed that owner David Tepper wouldn't be afraid to move on from Reich if he deemed it necessary for the success of his team.
"One thing about David Tepper: he's not very patient," Schefter said. "He's as successful as he is because of the way he's operated his business. And it's worked for him, basically at every level. He does what he wants. And I don't think that people are thinking that there's trouble right now with those people. |
31495 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
But as ESPN's Adam Schefter implied on "The Pat McAfee Show," the retread coach's seat is growing hotter with each passing week.
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. However, he detailed that owner David Tepper wouldn't be afraid to move on from Reich if he deemed it necessary for the success of his team.
"One thing about David Tepper: he's not very patient," Schefter said. "He's as successful as he is because of the way he's operated his business. And it's worked for him, basically at every level. He does what he wants. And I don't think that people are thinking that there's trouble right now with those people. But would anybody be surprised with anything that happens in Carolina this year? |
31496 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. However, he detailed that owner David Tepper wouldn't be afraid to move on from Reich if he deemed it necessary for the success of his team.
"One thing about David Tepper: he's not very patient," Schefter said. "He's as successful as he is because of the way he's operated his business. And it's worked for him, basically at every level. He does what he wants. And I don't think that people are thinking that there's trouble right now with those people. But would anybody be surprised with anything that happens in Carolina this year? No."
"One thing about David Tepper is he's not very patient and he does whatever he wants.. |
31497 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
"I don't think anybody's got a long rope there just because of the type of season that they're having," Schefter said when asked about Reich's status in Carolina.
Schefter stopped short of saying that Reich was on the hot seat. However, he detailed that owner David Tepper wouldn't be afraid to move on from Reich if he deemed it necessary for the success of his team.
"One thing about David Tepper: he's not very patient," Schefter said. "He's as successful as he is because of the way he's operated his business. And it's worked for him, basically at every level. He does what he wants. And I don't think that people are thinking that there's trouble right now with those people. But would anybody be surprised with anything that happens in Carolina this year? No."
"One thing about David Tepper is he's not very patient and he does whatever he wants..
I don't think anybody would be surprised if anything happens in Carolina with the season that they're having" ~ @AdamSchefter #PMSLive pic.twitter.com/PV7bfVUtHp — Pat McAfee (@PatMcAfeeShow) November 6, 2023
Schefter pointed to Carolina's firing of Rhule as an example of Tepper's impatience. |
31498 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
"One thing about David Tepper: he's not very patient," Schefter said. "He's as successful as he is because of the way he's operated his business. And it's worked for him, basically at every level. He does what he wants. And I don't think that people are thinking that there's trouble right now with those people. But would anybody be surprised with anything that happens in Carolina this year? No."
"One thing about David Tepper is he's not very patient and he does whatever he wants..
I don't think anybody would be surprised if anything happens in Carolina with the season that they're having" ~ @AdamSchefter #PMSLive pic.twitter.com/PV7bfVUtHp — Pat McAfee (@PatMcAfeeShow) November 6, 2023
Schefter pointed to Carolina's firing of Rhule as an example of Tepper's impatience. There had been rumors that the owner was going to wait things out with Rhule in the weeks leading up to his in-season departure. |
31499 | Will the Panthers fire Frank Reich? Impatient David Tepper could turn up Carolina's hot seat with 'Thursday Night Football' loss
And it's worked for him, basically at every level. He does what he wants. And I don't think that people are thinking that there's trouble right now with those people. But would anybody be surprised with anything that happens in Carolina this year? No."
"One thing about David Tepper is he's not very patient and he does whatever he wants..
I don't think anybody would be surprised if anything happens in Carolina with the season that they're having" ~ @AdamSchefter #PMSLive pic.twitter.com/PV7bfVUtHp — Pat McAfee (@PatMcAfeeShow) November 6, 2023
Schefter pointed to Carolina's firing of Rhule as an example of Tepper's impatience. There had been rumors that the owner was going to wait things out with Rhule in the weeks leading up to his in-season departure. Instead, he decided to pull the trigger and part with him. |
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