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wikidoc
ABHD6
ABHD6 alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene. # Function ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied ...
ABHD6 alpha/beta-Hydrolase domain containing 6 (ABHD6), also known as monoacylglycerol lipase ABHD6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 gene. # Function ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied...
https://www.wikidoc.org/index.php/ABHD6
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wikidoc
ACAA2
ACAA2 3-Ketoacyl-CoA thiolase, mitochondrial also known as acetyl-Coenzyme A acyltransferase 2 is an enzyme that in humans is encoded by the ACAA2 gene. Acetyl-Coenzyme A acyltransferase 2 is an acetyl-CoA C-acyltransferase enzyme. # Structure The ACAA2 gene encodes a 41.9 kDa protein that is composed of 397 amino aci...
ACAA2 3-Ketoacyl-CoA thiolase, mitochondrial also known as acetyl-Coenzyme A acyltransferase 2 is an enzyme that in humans is encoded by the ACAA2 gene.[1][2] Acetyl-Coenzyme A acyltransferase 2 is an acetyl-CoA C-acyltransferase enzyme. # Structure The ACAA2 gene encodes a 41.9 kDa protein that is composed of 397 am...
https://www.wikidoc.org/index.php/ACAA2
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wikidoc
ACACB
ACACB Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene. # Function Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting...
ACACB Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene.[1][2] # Function Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-l...
https://www.wikidoc.org/index.php/ACACB
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wikidoc
ACAD8
ACAD8 Isobutyryl-CoA dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ACAD8 gene on chromosome 11. The protein encoded by ACAD8 is a mitochondrial protein belongs to the acyl-CoA dehydrogenase family of enzymes, which function to catalyze the dehydrogenation of acyl-CoA derivatives in the meta...
ACAD8 Isobutyryl-CoA dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ACAD8 gene on chromosome 11.[1][2] The protein encoded by ACAD8 is a mitochondrial protein belongs to the acyl-CoA dehydrogenase family of enzymes, which function to catalyze the dehydrogenation of acyl-CoA derivatives in t...
https://www.wikidoc.org/index.php/ACAD8
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wikidoc
ACAD9
ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial is an enzyme that in humans is encoded by the ACAD9 gene. Mitochondrial Complex I Deficiency with varying clinical manifestations has been associated with mutations in ACAD9. # Structure The ACAD9 gene contains an open reading frame of 1866 base pairs; this g...
ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial is an enzyme that in humans is encoded by the ACAD9 gene.[1][2] Mitochondrial Complex I Deficiency with varying clinical manifestations has been associated with mutations in ACAD9.[3] # Structure The ACAD9 gene contains an open reading frame of 1866 base pai...
https://www.wikidoc.org/index.php/ACAD9
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wikidoc
ACADL
ACADL Acyl-CoA dehydrogenase, long chain is a protein that in humans is encoded by the ACADL gene. ACADL is a gene that encodes LCAD - acyl-CoA dehydrogenase, long chain - which is a member of the acyl-CoA dehydrogenase family. The acyl-CoA dehydrogenase family is primarily responsible for beta-oxidation of fatty acids...
ACADL Acyl-CoA dehydrogenase, long chain is a protein that in humans is encoded by the ACADL gene.[1] ACADL is a gene that encodes LCAD - acyl-CoA dehydrogenase, long chain - which is a member of the acyl-CoA dehydrogenase family. The acyl-CoA dehydrogenase family is primarily responsible for beta-oxidation of fatty a...
https://www.wikidoc.org/index.php/ACADL
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wikidoc
ACADM
ACADM ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as mil...
ACADM ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as mi...
https://www.wikidoc.org/index.php/ACADM
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wikidoc
ACADS
ACADS Acyl-CoA dehydrogenase, C-2 to C-3 short chain is an enzyme that in humans is encoded by the ACADS gene. This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway...
ACADS Acyl-CoA dehydrogenase, C-2 to C-3 short chain is an enzyme that in humans is encoded by the ACADS gene.[1] This gene encodes a tetrameric mitochondrial flavoprotein, which is a member of the acyl-CoA dehydrogenase family. This enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pat...
https://www.wikidoc.org/index.php/ACADS
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wikidoc
ACAT1
ACAT1 Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT1 (Acetyl-Coenzyme A acetyltransferase 1) gene. Acetyl-Coenzyme A acetyltransferase 1 is an acetyl-CoA C-acetyltransferase enzyme. # Structure The gene spans approx. 27 kb and co...
ACAT1 Acetyl-CoA acetyltransferase, mitochondrial, also known as acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT1 (Acetyl-Coenzyme A acetyltransferase 1) gene.[1] Acetyl-Coenzyme A acetyltransferase 1 is an acetyl-CoA C-acetyltransferase enzyme. # Structure The gene spans approx. 27 kb an...
https://www.wikidoc.org/index.php/ACAT1
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wikidoc
ACER1
ACER1 Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene. # Function ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P). # Model organisms Model organisms have been used in the study of...
ACER1 Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.[1] # Function ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).[1] # Model organisms Model organisms have been used in the s...
https://www.wikidoc.org/index.php/ACER1
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wikidoc
ACKR3
ACKR3 Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene. This gene encodes a member of the G protein-coupled receptor family. This protein was earlier thought to be a receptor for vaso...
ACKR3 Atypical chemokine receptor 3 also known as C-X-C chemokine receptor type 7 (CXCR-7) and G-protein coupled receptor 159 (GPR159) is a protein that in humans is encoded by the ACKR3 gene.[1][2] This gene encodes a member of the G protein-coupled receptor family. This protein was earlier thought to be a receptor f...
https://www.wikidoc.org/index.php/ACKR3
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wikidoc
ACOT1
ACOT1 Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene. # Structure The ACOT1 gene is located on the 14th chromosome, with its specific localization being 14q24.3. It contains 7 exons. The protein encoded by this gene contains 410 amino acids, and forms a homodimer with another chain. T...
ACOT1 Acyl-CoA thioesterase 1 is a protein that in humans is encoded by the ACOT1 gene.[1] # Structure The ACOT1 gene is located on the 14th chromosome, with its specific localization being 14q24.3. It contains 7 exons.[1] The protein encoded by this gene contains 410 amino acids, and forms a homodimer with another c...
https://www.wikidoc.org/index.php/ACOT1
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wikidoc
ACOT2
ACOT2 Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene. Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze Coenzyme A (CoA) esters, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid and CoA. ACO...
ACOT2 Acyl-CoA thioesterase 2, also known as ACOT2, is an enzyme which in humans is encoded by the ACOT2 gene.[1][2][3] Acyl-CoA thioesterases, such as ACOT2, are a group of enzymes that hydrolyze Coenzyme A (CoA) esters, such as acyl-CoAs, bile CoAs, and CoA esters of prostaglandins, to the corresponding free acid an...
https://www.wikidoc.org/index.php/ACOT2
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wikidoc
ACOT4
ACOT4 Acyl-coenzyme A thioesterase 4 is an enzyme that in humans is encoded by the ACOT4 gene. # Function The protein encoded by the ACOT4 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme A esters of various molecules to the free acid plus CoA. These enzymes have al...
ACOT4 Acyl-coenzyme A thioesterase 4 is an enzyme that in humans is encoded by the ACOT4 gene.[1][2][3] # Function The protein encoded by the ACOT4 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme A esters of various molecules to the free acid plus CoA. These enzym...
https://www.wikidoc.org/index.php/ACOT4
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wikidoc
ACOT6
ACOT6 Acyl-CoA thioesterase 6 is a protein that in humans is encoded by the ACOT6 gene. The protein, also known as C14orf42, is an enzyme with thioesterase activity. # Function The protein encoded by the ACOT1 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme A ester...
ACOT6 Acyl-CoA thioesterase 6 is a protein that in humans is encoded by the ACOT6 gene.[1] The protein, also known as C14orf42, is an enzyme with thioesterase activity.[1] # Function The protein encoded by the ACOT1 gene is part of a family of Acyl-CoA thioesterases, which catalyze the hydrolysis of various Coenzyme ...
https://www.wikidoc.org/index.php/ACOT6
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wikidoc
ACRRM
ACRRM ACRRM is the Australian College of Rural and Remote Medicine. It has a current membership of around 2,500 including fellows, registrars, practitioners and students. # History ACRRM was established in 1997 ACRRM received initial accreditation from the Australian Medical Council (AMC) in February 2007, and was in...
ACRRM Template:Primarysources ACRRM is the Australian College of Rural and Remote Medicine. It has a current membership of around 2,500 including fellows, registrars, practitioners and students.[1] # History ACRRM was established in 1997 ACRRM received initial accreditation from the Australian Medical Council (AMC) ...
https://www.wikidoc.org/index.php/ACRRM
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wikidoc
ACSF3
ACSF3 Acyl-CoA synthetase family member 3 is an enzyme that in humans is encoded by the ACSF3 gene. # Structure The ACSF3 gene is located on the 16th chromosome, with its specific location being 16q24.3. The gene contains 17 exons. ASCL4 encodes a 64.1 kDa protein that is composed of 576 amino acids; 20 peptides have ...
ACSF3 Acyl-CoA synthetase family member 3 is an enzyme that in humans is encoded by the ACSF3 gene.[1] # Structure The ACSF3 gene is located on the 16th chromosome, with its specific location being 16q24.3. The gene contains 17 exons.[1] ASCL4 encodes a 64.1 kDa protein that is composed of 576 amino acids; 20 peptide...
https://www.wikidoc.org/index.php/ACSF3
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wikidoc
ACSL1
ACSL1 Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene. # Structure ## Gene The ACSL4 gene is located on the 4th chromosome, with its specific location being 4q35.1. The gene contains 28 exons. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenz...
ACSL1 Long-chain-fatty-acid—CoA ligase 1 is an enzyme that in humans is encoded by the ACSL1 gene.[1][2][3] # Structure ## Gene The ACSL4 gene is located on the 4th chromosome, with its specific location being 4q35.1. The gene contains 28 exons.[3] The protein encoded by this gene is an isozyme of the long-chain fat...
https://www.wikidoc.org/index.php/ACSL1
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wikidoc
ACSL4
ACSL4 Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this fa...
ACSL4 Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene.[1][2][3] The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes ...
https://www.wikidoc.org/index.php/ACSL4
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wikidoc
ACSS2
ACSS2 Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene. # Function This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA from ac...
ACSS2 Acyl-coenzyme A synthetase short-chain family member 2 is an enzyme that in humans is encoded by the ACSS2 gene.[1][2] # Function This gene encodes a cytosolic enzyme that catalyzes the activation of acetate for use in lipid synthesis and energy generation. The protein acts as a monomer and produces acetyl-CoA ...
https://www.wikidoc.org/index.php/ACSS2
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wikidoc
ACTA2
ACTA2 Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24. Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which have bee...
ACTA2 Alpha-actin-2 also known as actin, aortic smooth muscle or alpha smooth muscle actin (α-SMA, SMactin, alpha-SM-actin, ASMA) is a protein that in humans is encoded by the ACTA2 gene located on 10q22-q24.[1][2] Actin alpha 2, the human aortic smooth muscle actin gene, is one of six different actin isoforms which h...
https://www.wikidoc.org/index.php/ACTA2
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wikidoc
ACTC1
ACTC1 ACTC1 encodes cardiac muscle alpha actin. This isoform differs from the alpha actin that is expressed in skeletal muscle, ACTA1. Alpha cardiac actin is the major protein of the thin filament in cardiac sarcomeres, which are responsible for muscle contraction and generation of force to support the pump function of...
ACTC1 ACTC1 encodes cardiac muscle alpha actin.[1][2] This isoform differs from the alpha actin that is expressed in skeletal muscle, ACTA1. Alpha cardiac actin is the major protein of the thin filament in cardiac sarcomeres, which are responsible for muscle contraction and generation of force to support the pump func...
https://www.wikidoc.org/index.php/ACTC1
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wikidoc
ACTG1
ACTG1 Gamma-actin is a protein that in humans is encoded by the ACTG1 gene. Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle cel...
ACTG1 Gamma-actin is a protein that in humans is encoded by the ACTG1 gene.[1] Gamma-actin is widely expressed in cellular cytoskeletons of many tissues; in adult striated muscle cells, gamma-actin is localized to Z-discs and costamere structures, which are responsible for force transduction and transmission in muscle...
https://www.wikidoc.org/index.php/ACTG1
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wikidoc
ACVR1
ACVR1 Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin receptor-like kinase-2). ACVR1 has been linked to the 2q23-24 region of the genome. This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for the devel...
ACVR1 Activin A receptor, type I (ACVR1) is a protein which in humans is encoded by the ACVR1 gene; also known as ALK-2 (activin receptor-like kinase-2).[1] ACVR1 has been linked to the 2q23-24 region of the genome.[2] This protein is important in the bone morphogenic protein (BMP) pathway which is responsible for th...
https://www.wikidoc.org/index.php/ACVR1
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wikidoc
AD-36
AD-36 AD-36 is one of 51 types of adenoviruses known to infect humans. It was first shown to be associated with obesity in chickens by Dr. Nikhil Dhurandhar. There has been a positive correlation between body fat and the presence of AD-36 antibodies in the blood. Previous research showed that chicken or mice injected w...
AD-36 Template:Taxobox begin Template:Taxobox begin placement virus Template:Taxobox group i entry Template:Taxobox familia entry Template:Taxobox genus entry Template:Taxobox species entry Template:Taxobox serotype entry Template:Taxobox end placement Template:Taxobox end AD-36 is one of 51 types of adenoviruses know...
https://www.wikidoc.org/index.php/AD-36
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wikidoc
PSEN2
PSEN2 Lua error in Module:Redirect at line 65: could not parse redirect on page "AD4". Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. # Function Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precu...
PSEN2 Lua error in Module:Redirect at line 65: could not parse redirect on page "AD4". Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene.[1] # Function Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid p...
https://www.wikidoc.org/index.php/AD4
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wikidoc
ADAM7
ADAM7 Disintegrin and metalloproteinase domain-containing protein 7 is a protein that in humans is encoded by the ADAM7 gene. ADAM7 is an 85-kDa enzyme that is a member of the transmembrane ADAM (A Disintegrin and Metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally relat...
ADAM7 Disintegrin and metalloproteinase domain-containing protein 7 is a protein that in humans is encoded by the ADAM7 gene.[1] ADAM7 is an 85-kDa enzyme that is a member of the transmembrane ADAM (A Disintegrin and Metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally r...
https://www.wikidoc.org/index.php/ADAM7
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wikidoc
ADCK3
ADCK3 Lua error in Module:About-distinguish at line 61: attempt to index field 'wikibase' (a nil value). aarF domain containing kinase 3 is a protein that in humans is encoded by the ADCK3 gene. This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein...
ADCK3 Lua error in Module:About-distinguish at line 61: attempt to index field 'wikibase' (a nil value). aarF domain containing kinase 3 is a protein that in humans is encoded by the ADCK3 gene.[1] This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane pro...
https://www.wikidoc.org/index.php/ADCK3
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wikidoc
ADCY1
ADCY1 Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene. This gene encodes a form of adenylyl cyclase expressed in brain. A similar protein in mice is involved in pattern formation of the brain. # Function ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be ...
ADCY1 Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.[1][2] This gene encodes a form of adenylyl cyclase expressed in brain. A similar protein in mice is involved in pattern formation of the brain.[2] # Function ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, ...
https://www.wikidoc.org/index.php/ADCY1
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wikidoc
ADCY2
ADCY2 Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene. It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains. ADCY2 is one of ten different mammalian isoforms of adenylyl cyclases. ADCY2 ...
ADCY2 Adenylyl cyclase type 2 is an enzyme typically expressed in the brain of humans, that is encoded by the ADCY2 gene.[1][2] It belongs to the adenylyl cyclase class-3 or guanylyl cyclase family because it contains two guanylate cyclase domains.[3] ADCY2 is one of ten different mammalian isoforms of adenylyl cyclas...
https://www.wikidoc.org/index.php/ADCY2
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wikidoc
ADCY3
ADCY3 Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene. # Function This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The ADCY3 subtype likely mediates odorant detectio...
ADCY3 Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.[1][2] # Function This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP).[2] The ADCY3 subtype likely mediates odoran...
https://www.wikidoc.org/index.php/ADCY3
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wikidoc
ADH1B
ADH1B Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene. The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols, hydro...
ADH1B Alcohol dehydrogenase 1B is an enzyme that in humans is encoded by the ADH1B gene.[1][2] The protein encoded by this gene is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol (beverage alcohol), retinol, other aliphatic alcohols...
https://www.wikidoc.org/index.php/ADH1B
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wikidoc
ADRM1
ADRM1 Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene. Recent evidences on proteasome complex structure confirmed that the protein encoded by gene ADRM1, also known as 26S Proteasome regulatory subunit Rpn13 (systematic nomenclature for proteasome subunits), is a subunit of...
ADRM1 Proteasomal ubiquitin receptor ADRM1 is a protein that in humans is encoded by the ADRM1 gene.[1][2] Recent evidences on proteasome complex structure confirmed that the protein encoded by gene ADRM1, also known as 26S Proteasome regulatory subunit Rpn13 (systematic nomenclature for proteasome subunits), is a sub...
https://www.wikidoc.org/index.php/ADRM1
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wikidoc
AEBP2
AEBP2 Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potent...
AEBP2 Adipocyte Enhancer-Binding Protein is a zinc finger protein that in humans is encoded by the evolutionarily well-conserved gene AEBP2. It was initially identified due to its binding capability to the promoter[1] of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a po...
https://www.wikidoc.org/index.php/AEBP2
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wikidoc
AGG01
AGG01 AGG01 is the tentative name of a new Penicillin-class antibiotic, recently discovered in the breast milk of the Tammar Wallaby, reportedly one hundred times more powerful than penicillin. This compound was found to be effective against MRSA, E. coli, Streptococci, Salmonella, Bacillus subtilis, Pseudomonas spp.,...
AGG01 AGG01 is the tentative name of a new Penicillin-class antibiotic, recently discovered in the breast milk[1] of the Tammar Wallaby, reportedly one hundred times more powerful than penicillin. This compound was found to be effective against MRSA, E. coli, Streptococci, Salmonella, Bacillus subtilis, Pseudomonas s...
https://www.wikidoc.org/index.php/AGG01
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wikidoc
AGGF1
AGGF1 Angiogenic factor with G patch and FHA domains 1 is a protein that in humans is encoded by the AGGF1 gene. AGGF1 is a human gene that functions as an angiogenic factor with a G-patch and forkhead-associated domain. This gene is predominantly expressed in activated, plump endothelial cells and acts to regulate ang...
AGGF1 Angiogenic factor with G patch and FHA domains 1 is a protein that in humans is encoded by the AGGF1 gene.[1][2][3] AGGF1 is a human gene that functions as an angiogenic factor with a G-patch and forkhead-associated domain.[4] This gene is predominantly expressed in activated, plump endothelial cells and acts to...
https://www.wikidoc.org/index.php/AGGF1
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wikidoc
AIFM1
AIFM1 Apoptosis-inducing factor 1, mitochondrial is a protein that in humans is encoded by the AIFM1 gene on the X chromosome. This protein localizes to the mitochondria, as well as the nucleus, where it carries out nuclear fragmentation as part of caspase-independent apoptosis. # Structure AIFM1 is expressed as a 613...
AIFM1 Apoptosis-inducing factor 1, mitochondrial is a protein that in humans is encoded by the AIFM1 gene on the X chromosome.[1][2] This protein localizes to the mitochondria, as well as the nucleus, where it carries out nuclear fragmentation as part of caspase-independent apoptosis.[3] # Structure AIFM1 is expresse...
https://www.wikidoc.org/index.php/AIFM1
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wikidoc
AIFM2
AIFM2 Apoptosis-inducing factor 2 (AIFM2), also known as apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10. This gene encodes a flavoprotein oxidoreductase that bin...
AIFM2 Apoptosis-inducing factor 2 (AIFM2), also known as apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10.[1][2][3][4] This gene encodes a flavoprotein oxidoreduc...
https://www.wikidoc.org/index.php/AIFM2
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wikidoc
AKAP4
AKAP4 A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene. It involves in the intracellular signalling of protein kinase -A. AKAP4 is called as cancer /testis antigen (CTA), it belongs to a class of tumour linked antigens categories by high expression in germ cells and cancer tha...
AKAP4 A-kinase anchor protein 4 is a scaffold protein that in humans is encoded by the AKAP4 gene.[1][2][3] It involves in the intracellular signalling of protein kinase -A.[4] AKAP4 is called as cancer /testis antigen (CTA), it belongs to a class of tumour linked antigens categories by high expression in germ cells a...
https://www.wikidoc.org/index.php/AKAP4
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wikidoc
AKAP6
AKAP6 A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene. The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations wi...
AKAP6 A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.[1][2][3] The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete lo...
https://www.wikidoc.org/index.php/AKAP6
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wikidoc
AKAP9
AKAP9 A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450 # Function The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have th...
AKAP9 A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene.[1][2][3] AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450 [4] # Function The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins ...
https://www.wikidoc.org/index.php/AKAP9
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wikidoc
AKTIP
AKTIP AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene. The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities ...
AKTIP AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.[1][2][3] The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abno...
https://www.wikidoc.org/index.php/AKTIP
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wikidoc
ALARA
ALARA See also: radiation protection # Overview ALARA is an acronym for an important principle in radiation protection and stands for "As Low As Reasonably Achievable". The aim is to minimize the risk of radioactive exposure or amount of dose while keeping in mind that some exposure may be acceptable in order to furth...
ALARA See also: radiation protection # Overview ALARA is an acronym for an important principle in radiation protection and stands for "As Low As Reasonably Achievable". The aim is to minimize the risk of radioactive exposure or amount of dose while keeping in mind that some exposure may be acceptable in order to furt...
https://www.wikidoc.org/index.php/ALARA
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wikidoc
ALAS2
ALAS2 Delta-aminolevulinate synthase 2 also known as ALAS2 is a protein that in humans is encoded by the ALAS2 gene. ALAS2 is an aminolevulinic acid synthase. The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosynthetic pa...
ALAS2 Delta-aminolevulinate synthase 2 also known as ALAS2 is a protein that in humans is encoded by the ALAS2 gene.[1][2][3] ALAS2 is an aminolevulinic acid synthase. The product of this gene specifies an erythroid-specific mitochondrially located enzyme. The encoded protein catalyzes the first step in the heme biosy...
https://www.wikidoc.org/index.php/ALAS2
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wikidoc
ALCAM
ALCAM CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene. It is also called CD166 (cluster of differentiation 166), MEMD, SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. Some literature sources...
ALCAM CD166 antigen is a 100-105 kD typeI transmembrane glycoprotein that is a member of the immunoglobulin superfamily of proteins. In humans it is encoded by the ALCAM gene.[1][2] It is also called CD166 (cluster of differentiation 166), MEMD,[3] SC-1/DM-GRASP/BEN in the chicken, and KG-CAM in the rat. Some literatu...
https://www.wikidoc.org/index.php/ALCAM
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wikidoc
ALDH2
ALDH2 Aldehyde dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ALDH2 gene located on chromosome 12. This protein belongs to the aldehyde dehydrogenase family of enzymes. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms...
ALDH2 Aldehyde dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the ALDH2 gene located on chromosome 12.[1][2] This protein belongs to the aldehyde dehydrogenase family of enzymes. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver i...
https://www.wikidoc.org/index.php/ALDH2
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wikidoc
ALMS1
ALMS1 Alstrom syndrome 1 also known as ALMS1 is a protein which in humans is encoded by the ALMS1 gene. # Molecular biology The gene is located on the short arm of chromosome 2 (2p13.2) on the plus (Watson) strand. It is 224,161 bases in length organised into 23 exons. The encoded protein has 4,167 amino acids and mol...
ALMS1 Alstrom syndrome 1 also known as ALMS1 is a protein which in humans is encoded by the ALMS1 gene.[1][2] # Molecular biology The gene is located on the short arm of chromosome 2 (2p13.2) on the plus (Watson) strand. It is 224,161 bases in length organised into 23 exons. The encoded protein has 4,167 amino acids ...
https://www.wikidoc.org/index.php/ALMS1
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wikidoc
AMELX
AMELX Amelogenin, X isoform is a protein that in humans is encoded by the AMELX (amelogenin, X isoform) gene. The protein Amelogenin, X isoform is an isoform of amelogenin that comes from the X chromosome. The protein Amelogenin is a type of extracellular matrix protein, and is involved in the process of amelogenesis, ...
AMELX Amelogenin, X isoform is a protein that in humans is encoded by the AMELX (amelogenin, X isoform) gene.[1] The protein Amelogenin, X isoform is an isoform of amelogenin that comes from the X chromosome.[2][3] The protein Amelogenin is a type of extracellular matrix protein, and is involved in the process of amel...
https://www.wikidoc.org/index.php/AMELX
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wikidoc
AMPD3
AMPD3 AMP deaminase 3 is an enzyme that in humans is encoded by the AMPD3 gene. This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenylate cat...
AMPD3 AMP deaminase 3 is an enzyme that in humans is encoded by the AMPD3 gene.[1][2] This gene encodes a member of the AMP deaminase gene family. The encoded protein is a highly regulated enzyme that catalyzes the hydrolytic deamination of adenosine monophosphate to inosine monophosphate, a branch point in the adenyl...
https://www.wikidoc.org/index.php/AMPD3
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wikidoc
ANKK1
ANKK1 Ankyrin repeat and kinase domain containing 1 (ANKK1) also known as protein kinase PKK2 or sugen kinase 288 (SgK288) is an enzyme that in humans is encoded by the ANKK1 gene. The ANKK1 is a member of an extensive family of the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal tran...
ANKK1 Ankyrin repeat and kinase domain containing 1 (ANKK1) also known as protein kinase PKK2 or sugen kinase 288 (SgK288) is an enzyme that in humans is encoded by the ANKK1 gene. The ANKK1 is a member of an extensive family of the Ser/Thr protein kinase family, and protein kinase superfamily involved in signal tra...
https://www.wikidoc.org/index.php/ANKK1
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wikidoc
Aorta
Aorta The aorta (generally pronounced eɪˈɔːtə or "ay-orta") is the largest artery in the human body, originating from the left ventricle of the heart and bringing oxygenated blood to all parts of the body in the systemic circulation. # The course of the aorta The aorta is usually divided into five segments/sections ...
Aorta Template:Infobox Artery Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2] The aorta (generally pronounced eɪˈɔːtə or "ay-orta") is the largest artery in the human body, originating from the left ventricle of the heart and bringing oxygenated blood to all ...
https://www.wikidoc.org/index.php/AO
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wikidoc
AP1S1
AP1S1 AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene. # Function The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as...
AP1S1 AP-1 complex subunit sigma-1A is a protein that in humans is encoded by the AP1S1 gene.[1][2][3] # Function The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This p...
https://www.wikidoc.org/index.php/AP1S1
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wikidoc
AP2M1
AP2M1 AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene. # Function This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATP...
AP2M1 AP-2 complex subunit mu is a protein that in humans is encoded by the AP2M1 gene.[1] # Function This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar...
https://www.wikidoc.org/index.php/AP2M1
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wikidoc
AP4B1
AP4B1 AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene. # Function The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) and epsil...
AP4B1 AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.[1][2] # Function The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1, this protein) an...
https://www.wikidoc.org/index.php/AP4B1
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wikidoc
AP4E1
AP4E1 AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene. # Function The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1...
AP4E1 AP-4 complex subunit epsilon-1 is a protein that in humans is encoded by the AP4E1 gene.[1] # Function The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (A...
https://www.wikidoc.org/index.php/AP4E1
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wikidoc
AP4M1
AP4M1 AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene. # Function This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo prote...
AP4M1 AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.[1][2][3] # Function This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of c...
https://www.wikidoc.org/index.php/AP4M1
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wikidoc
AP4S1
AP4S1 AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene. # Function The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1),...
AP4S1 AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene.[1] # Function The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4...
https://www.wikidoc.org/index.php/AP4S1
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wikidoc
APAF1
APAF1 Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. # Function This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein contains (from the N terminal) a caspase recruitment domain (CARD), an ...
APAF1 Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene.[1][2][3] # Function This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein contains (from the N terminal) a caspase recruitment domain (...
https://www.wikidoc.org/index.php/APAF1
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wikidoc
APBA1
APBA1 Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene. # Function The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It...
APBA1 Amyloid beta A4 precursor protein-binding family A member 1 is a protein that in humans is encoded by the APBA1 gene.[1][2][3] # Function The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein...
https://www.wikidoc.org/index.php/APBA1
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wikidoc
APBA2
APBA2 Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene. # Function The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It...
APBA2 Amyloid beta A4 precursor protein-binding family A member 2 is a protein that in humans is encoded by the APBA2 gene.[1][2] # Function The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (A...
https://www.wikidoc.org/index.php/APBA2
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wikidoc
APBB1
APBB1 Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene. # Function The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor ...
APBB1 Amyloid beta A4 precursor protein-binding family B member 1 is a protein that in humans is encoded by the APBB1 gene.[1][2][3] # Function The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid ...
https://www.wikidoc.org/index.php/APBB1
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wikidoc
APEX1
APEX1 DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene. Apurinic/apyrimidinic (AP) sites (also called "abasic sites") occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites...
APEX1 DNA-(apurinic or apyrimidinic site) lyase is an enzyme that in humans is encoded by the APEX1 gene. Apurinic/apyrimidinic (AP) sites (also called "abasic sites") occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP site...
https://www.wikidoc.org/index.php/APEX1
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wikidoc
APLP1
APLP1 Amyloid-like protein 1, also known as APLP1, is a protein that in humans is encoded by the APLP1 gene. APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis. # Function This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a ...
APLP1 Amyloid-like protein 1, also known as APLP1, is a protein that in humans is encoded by the APLP1 gene.[1][2] APLP1 along with APLP2 are important modulators of glucose and insulin homeostasis.[3] # Function This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded pro...
https://www.wikidoc.org/index.php/APLP1
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wikidoc
APLP2
APLP2 Amyloid-like protein 2, also known as APLP2, is a protein that in humans is encoded by the APLP2 gene. APLP2 along with APLP1 are important modulators of glucose and insulin homeostasis. # Gene location The human APLP2 gene is located on the long (q) arm of chromosome 11 at region 2 band 4, from base pair 130, 0...
APLP2 Amyloid-like protein 2, also known as APLP2, is a protein that in humans is encoded by the APLP2 gene.[1][2] APLP2 along with APLP1 are important modulators of glucose and insulin homeostasis.[3] # Gene location The human APLP2 gene is located on the long (q) arm of chromosome 11 at region 2 band 4, from base p...
https://www.wikidoc.org/index.php/APLP2
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wikidoc
APOA2
APOA2 Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene. # Function This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D....
APOA2 Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[1] # Function This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotei...
https://www.wikidoc.org/index.php/APOA2
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wikidoc
APOA4
APOA4 Apolipoprotein A-IV (also known as apoA-IV, apoAIV, or apoA4) is plasma protein that is the product of the human gene APOA4. # Gene APOA4 resides on chromosome 11 in close linkage to APOA1 and APOC3. APOA4 contains 3 exons separated by two introns, and is polymorphic, although most of the reported sequence polym...
APOA4 Apolipoprotein A-IV (also known as apoA-IV, apoAIV, or apoA4) is plasma protein that is the product of the human gene APOA4.[1][2] # Gene APOA4 resides on chromosome 11 in close linkage to APOA1 and APOC3. APOA4 contains 3 exons separated by two introns, and is polymorphic, although most of the reported sequenc...
https://www.wikidoc.org/index.php/APOA4
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wikidoc
APOA5
APOA5 Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11. It is significantly expressed in liver. The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component...
APOA5 Apolipoprotein A-V is a protein that in humans is encoded by the APOA5 gene on chromosome 11.[1][2][3] It is significantly expressed in liver.[4] The protein encoded by this gene is an apolipoprotein and an important determinant of plasma triglyceride levels, a major risk factor for coronary artery disease. It i...
https://www.wikidoc.org/index.php/APOA5
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wikidoc
APOL2
APOL2 Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene. This gene is a member of the apolipoprotein L gene family and protein in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp. Localization of this protein is mainly found i...
APOL2 Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene.[1][2][3] This gene is a member of the apolipoprotein L gene family and protein in this family are lipid-binding proteins. This gene encodes a 37.1 kDa protein and The protein sequence contains 337bp. Localization of this protein is main...
https://www.wikidoc.org/index.php/APOL2
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wikidoc
APPL1
APPL1 Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1), or DCC-interacting protein 13-alpha (DIP13alpha), is a protein that in humans is encoded by the APPL1 gene. APPL1 contains several key interactory domains: pleckstrin homology (PH) domain, phosphotyrosine-binding (PTB) domai...
APPL1 Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 (APPL1), or DCC-interacting protein 13-alpha (DIP13alpha), is a protein that in humans is encoded by the APPL1 gene.[1][2][3] APPL1 contains several key interactory domains: pleckstrin homology (PH) domain, phosphotyrosine-binding (...
https://www.wikidoc.org/index.php/APPL1
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wikidoc
APPL2
APPL2 DCC-interacting protein 13-beta is a protein that in humans is encoded by the APPL2 gene. # Model organisms Model organisms have been used in the study of APPL2 function. A conditional knockout mouse line, called Appl2tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a...
APPL2 DCC-interacting protein 13-beta is a protein that in humans is encoded by the APPL2 gene.[1][2][3] # Model organisms Model organisms have been used in the study of APPL2 function. A conditional knockout mouse line, called Appl2tm1a(KOMP)Wtsi[8][9] was generated as part of the International Knockout Mouse Consor...
https://www.wikidoc.org/index.php/APPL2
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wikidoc
ARID2
ARID2 AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene. # Function ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors. # Structure The ARID2 protein contains tw...
ARID2 AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.[1] # Function ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.[1] # Structure The ARID2 protein cont...
https://www.wikidoc.org/index.php/ARID2
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wikidoc
ARL4D
ARL4D ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene. # Function ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an unusuall...
ARL4D ADP-ribosylation factor-like protein 4D is a protein that in humans is encoded by the ARL4D gene.[1][2] # Function ADP-ribosylation factor 4D is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL4D is closely similar to ARL4A and ARL4C and each has a nuclear localization signal and an u...
https://www.wikidoc.org/index.php/ARL4D
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wikidoc
ARMC6
ARMC6 The human gene ARMC6 encodes a protein called Armadillo repeat-containing protein 6. The function of this gene's protein product has not been determined. A related protein in mouse suggests that this protein has a conserved function. The protein is characterized by the presence of armadillo repeats in its amino a...
ARMC6 The human gene ARMC6 encodes a protein called Armadillo repeat-containing protein 6.[1][2] The function of this gene's protein product has not been determined. A related protein in mouse suggests that this protein has a conserved function.[2] The protein is characterized by the presence of armadillo repeats in i...
https://www.wikidoc.org/index.php/ARMC6
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wikidoc
ARPC4
ARPC4 Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene. # Function This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved throu...
ARPC4 Actin-related protein 2/3 complex subunit 4 is a protein that in humans is encoded by the ARPC4 gene.[1][2][3] # Function This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conse...
https://www.wikidoc.org/index.php/ARPC4
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wikidoc
ARVD1
ARVD1 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 1; # Overview # Pathophysiology The pathogenesis of ARVD involves apoptosis with fatty and fibro-fatty infiltration of the right ventricular free wall leading to heart failure and ventricular arrhythmias. ## Genetics There is an autosomal d...
ARVD1 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 1; # Overview # Pathophysiology The pathogenesis of ARVD involves apoptosis with fatty and fibro-fatty infiltration of the right ventricular free wall leading to heart failure and ventricul...
https://www.wikidoc.org/index.php/ARVD1
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wikidoc
ARVD2
ARVD2 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 2; arrhythmogenic right ventricular cardiomyopathy 2; ARVC2 # Overview Arrhythmogenic right ventricular dysplasia type 2 is a "concealed form" of ARVD. There is no change in heart size. There are no EKG changes on the resting electrocardiogr...
ARVD2 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 2; arrhythmogenic right ventricular cardiomyopathy 2; ARVC2 # Overview Arrhythmogenic right ventricular dysplasia type 2 is a "concealed form" of ARVD. There is no change in heart size. The...
https://www.wikidoc.org/index.php/ARVD2
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wikidoc
ARVD3
ARVD3 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 3; arrhythmogenic right ventricular cardiomyopathy 3; ARVC3 # Overview # Pathophysiology The pathogenesis of ARVD involves apoptosis with fatty and fibro-fatty infiltration of the right ventricular free wall leading to heart failure and ven...
ARVD3 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 3; arrhythmogenic right ventricular cardiomyopathy 3; ARVC3 # Overview # Pathophysiology The pathogenesis of ARVD involves apoptosis with fatty and fibro-fatty infiltration of the right ve...
https://www.wikidoc.org/index.php/ARVD3
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wikidoc
ARVD4
ARVD4 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 4; arrhythmogenic right ventricular cardiomyopathy 4; ARVC4 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas ...
ARVD4 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 4; arrhythmogenic right ventricular cardiomyopathy 4; ARVC4 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right v...
https://www.wikidoc.org/index.php/ARVD4
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wikidoc
ARVD5
ARVD5 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 5; arrhythmogenic right ventricular cardiomyopathy 5; ARVC5 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas ...
ARVD5 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 5; arrhythmogenic right ventricular cardiomyopathy 5; ARVC5 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right v...
https://www.wikidoc.org/index.php/ARVD5
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wikidoc
ARVD6
ARVD6 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 6; arrhythmogenic right ventricular cardiomyopathy 6; ARVC6 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas ...
ARVD6 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 6; arrhythmogenic right ventricular cardiomyopathy 6; ARVC6 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right v...
https://www.wikidoc.org/index.php/ARVD6
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wikidoc
ARVD7
ARVD7 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 7; arrhythmogenic right ventricular cardiomyopathy 7; ARVC7 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas ...
ARVD7 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 7; arrhythmogenic right ventricular cardiomyopathy 7; ARVC7 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right v...
https://www.wikidoc.org/index.php/ARVD7
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wikidoc
ARVD8
ARVD8 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 8; arrhythmogenic right ventricular cardiomyopathy 8; ARVC8 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas ...
ARVD8 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 8; arrhythmogenic right ventricular cardiomyopathy 8; ARVC8 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right v...
https://www.wikidoc.org/index.php/ARVD8
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wikidoc
ARVD9
ARVD9 Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 9; arrhythmogenic right ventricular cardiomyopathy 9; ARVC9 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right ventricle. It is characterized by hypokinetic areas ...
ARVD9 Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Synonyms and keywords: Arrhythmogenic right ventricular dysplasia type 9; arrhythmogenic right ventricular cardiomyopathy 9; ARVC9 # Overview Arrhythmogenic right ventricular dysplasia is a type of nonischemic cardiomyopathy that involves primarily the right v...
https://www.wikidoc.org/index.php/ARVD9
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wikidoc
ASCL1
ASCL1 Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene. Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1. # Function This gene encodes a member of the basic helix...
ASCL1 Achaete-scute homolog 1 is a protein that in humans is encoded by the ASCL1 gene.[1][2] Because it was discovered subsequent to studies on its homolog in Drosophila, the Achaete-scute complex, it was originally named MASH-1 for mammalian achaete scute homolog-1.[3] # Function This gene encodes a member of the b...
https://www.wikidoc.org/index.php/ASCL1
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wikidoc
ASF1A
ASF1A Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene. # Function This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucl...
ASF1A Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene.[1][2][3] # Function This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functio...
https://www.wikidoc.org/index.php/ASF1A
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wikidoc
ASF1B
ASF1B Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene. # Function This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family of cell c...
ASF1B Histone chaperone ASF1B is a protein that in humans is encoded by the ASF1B gene.[1][2][3] # Function This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The encoded protein is the substrate of the tousled-like kinase family...
https://www.wikidoc.org/index.php/ASF1B
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wikidoc
ASH1L
ASH1L ASH1L (also called huASH1, ASH1, ASH1L1, ASH1-like, or KMT2H) is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. ASH1L is the human homolog of Drosophila Ash1 (absent, small, or homeotic-like). # Gene Ash1 was discovered as a gene causing an imaginal disc ...
ASH1L ASH1L (also called huASH1, ASH1, ASH1L1, ASH1-like, or KMT2H) is a histone-lysine N-methyltransferase enzyme encoded by the ASH1L gene located at chromosomal band 1q22. ASH1L is the human homolog of Drosophila Ash1 (absent, small, or homeotic-like). # Gene Ash1 was discovered as a gene causing an imaginal disc...
https://www.wikidoc.org/index.php/ASH1L
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wikidoc
ASIC1
ASIC1 Acid-sensing ion channel 1 (ASIC1) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel 2 (BNaC2) is a protein that in humans is encoded by the ASIC1 gene. The ASIC1 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels ...
ASIC1 Acid-sensing ion channel 1 (ASIC1) also known as amiloride-sensitive cation channel 2, neuronal (ACCN2) or brain sodium channel 2 (BNaC2) is a protein that in humans is encoded by the ASIC1 gene. The ASIC1 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels...
https://www.wikidoc.org/index.php/ASIC1
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wikidoc
ASIC2
ASIC2 Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1) is a protein that in humans is encoded by the ASIC2 gene. The ASIC2 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels ...
ASIC2 Acid-sensing ion channel 2 (ASIC2) also known as amiloride-sensitive cation channel 1, neuronal (ACCN1) or brain sodium channel 1 (BNaC1) is a protein that in humans is encoded by the ASIC2 gene. The ASIC2 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels...
https://www.wikidoc.org/index.php/ASIC2
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wikidoc
ASIC3
ASIC3 Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in...
ASIC3 Acid-sensing ion channel 3 (ASIC3) also known as amiloride-sensitive cation channel 3 (ACCN3) or testis sodium channel 1 (TNaC1) is a protein that in humans is encoded by the ASIC3 gene. The ASIC3 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) i...
https://www.wikidoc.org/index.php/ASIC3
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wikidoc
ASIC4
ASIC4 Acid-sensing ion channel 4 (ASIC4) also known as amiloride-sensitive cation channel 4 (ACCN4) is a protein that in humans is encoded by the ASIC4 gene. The ASIC4 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals. The cDNA of this gene was...
ASIC4 Acid-sensing ion channel 4 (ASIC4) also known as amiloride-sensitive cation channel 4 (ACCN4) is a protein that in humans is encoded by the ASIC4 gene. The ASIC4 gene is one of the five paralogous genes that encode proteins that form trimeric acid-sensing ion channels (ASICs) in mammals.[1] The cDNA of this gene...
https://www.wikidoc.org/index.php/ASIC4
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wikidoc
ASK-1
ASK-1 Apoptosis signal-regulating kinase 1, ASK-1, is part of the mitogen-activated protein kinase (MAPK) cascade. In humans it is also known as "mitogen-activated protein kinase kinase kinase 5", abbreviated as "MAP3K5". Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-re...
ASK-1 Apoptosis signal-regulating kinase 1, ASK-1, is part of the mitogen-activated protein kinase (MAPK) cascade. In humans it is also known as "mitogen-activated protein kinase kinase kinase 5", abbreviated as "MAP3K5". Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-r...
https://www.wikidoc.org/index.php/ASK-1
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wikidoc
ASXL1
ASXL1 Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene. In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of pr...
ASXL1 Putative Polycomb group protein ASXL1 is a protein that in humans is encoded by the ASXL1 gene.[1][2] In Drosophila, the Additional sex combs (Asx) gene encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb grou...
https://www.wikidoc.org/index.php/ASXL1
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wikidoc
ATG12
ATG12 Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene. Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ...
ATG12 Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene.[1][2] Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degrad...
https://www.wikidoc.org/index.php/ATG12
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wikidoc
ATG4B
ATG4B Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene. # Function Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamor...
ATG4B Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene.[1][2] # Function Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, ...
https://www.wikidoc.org/index.php/ATG4B
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wikidoc
ATG4D
ATG4D The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase. # Function Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamo...
ATG4D The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[1] # Function Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, me...
https://www.wikidoc.org/index.php/ATG4D
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wikidoc
ATOX1
ATOX1 ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans. In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B. Homologous proteins are found in a wide variety of eukaryotes, including Saccharomyces cerevisiae...
ATOX1 ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans.[1][2] In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B.[3][4][5] Homologous proteins are found in a wide variety of eukaryotes, including Saccharo...
https://www.wikidoc.org/index.php/ATOX1
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wikidoc
ATP5D
ATP5D ATP synthase subunit delta, mitochondrial, also known as ATP synthase F1 subunit delta or F-ATPase delta subunit is an enzyme that in humans is encoded by the ATP5F1D (formerly ATP5D) gene. This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an ...
ATP5D ATP synthase subunit delta, mitochondrial, also known as ATP synthase F1 subunit delta or F-ATPase delta subunit is an enzyme that in humans is encoded by the ATP5F1D (formerly ATP5D) gene.[1][2][3] This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, uti...
https://www.wikidoc.org/index.php/ATP5D
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wikidoc
ATP5E
ATP5E ATP synthase F1 subunit epsilon, mitochondrial is an enzyme that in humans is encoded by the ATP5F1E gene. The protein encoded by ATP5F1E is a subunit of ATP synthase, also known as Complex V. Variations of this gene have been associated with mitochondrial complex V deficiency, nuclear 3 (MC5DN3) and Papillary Th...
ATP5E ATP synthase F1 subunit epsilon, mitochondrial is an enzyme that in humans is encoded by the ATP5F1E gene.[1][2] The protein encoded by ATP5F1E is a subunit of ATP synthase, also known as Complex V. Variations of this gene have been associated with mitochondrial complex V deficiency, nuclear 3 (MC5DN3) and Papil...
https://www.wikidoc.org/index.php/ATP5E
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wikidoc
ATP5H
ATP5H The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit...
ATP5H The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.[1][2] Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-...
https://www.wikidoc.org/index.php/ATP5H