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Sufentanil NanoTab(registered trademark) PCA system: Phase 3 active-comparator data versus IV PCA morphine for post-operative pain
Surgical Management of Osteoarthritis of the Knee CPG
Introduction: Intravenous patient-controlled analgesia (IV PCA) is commonly used to manage postoperative pain. However, it is associated with limitations, including programming errors and reduced patient mobility. Sufentanil is an opioid approved as IV and epidural formulations. While it possesses a high therapeutic in...
0
Recent progress in the treatment and prevention of cancer-related lymphedema
Panniculectomy & Abdominoplasty CPG
Answer questions and earn CME/CNE This article provides an overview of the recent developments in the diagnosis, treatment, and prevention of cancer-related lymphedema. Lymphedema incidence by tumor site is evaluated. Measurement techniques and trends in patient education and treatment are also summarized to include cu...
0
Fatal Complications of Aesthetic Techniques: The Gluteal Region
Panniculectomy & Abdominoplasty CPG
Cosmetic procedures are common and utilize many techniques to obtain aesthetically good outcomes for patient satisfaction with acceptable safety standards. Cosmetic procedures that involve the gluteal region are becoming increasingly popular as various procedures can target the gluteal region such as liposuction, tumes...
0
Effect of osteoprotegerin and osteoprotegerin ligand on osteoclast formation by arthroplasty membrane derived macrophages
AAHKS (2) Corticosteroids
OBJECTIVE: Osteoprotegerin ligand (OPGL) is a newly discovered molecule, which is expressed by osteoblasts/bone stromal cells. This ligand and M-CSF are now known to be essential for osteoclast differentiation from marrow and circulating precursors. This study examined whether OPGL and its soluble receptor osteoprotege...
0
The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture
Management of Hip Fractures in the Elderly
OBJECTIVES: To evaluate the effects of MK-0677, an orally active growth hormone (GH) secretagogue, on functional recovery from hip fracture in previously mobile older individuals. DESIGN: Placebo-controlled, randomized, double-blind trial. SETTING: Thirteen medical centers in England, Sweden, Denmark, Belgium, Switzerl...
0
Limb trauma with arterial injury: long-term performance of venous interposition grafts
DOD - Acute Comp Syndrome CPG
BACKGROUND: In contrast to arterial occlusive disease, data on long-term outcomes after vein grafts in limb trauma with arterial injury are sparse. PATIENTS: From 1991 through 2001, 22 trauma victims received 23 interposition vein grafts performed by an interdisciplinary team of trauma and vascular surgeons. Indication...
0
Recent advances in breast cancer (the Twenty-fourth San Antonio Breast Cancer Symposium, December, 2001)
MSTS 2018 - Femur Mets and MM
This paper reviews the Twenty-fourth Annual San Antonio Breast Cancer Symposium. The preliminary results of the ATAC study have shown that Arimidex is superior to tamoxifen in postmenopausal women with ER-positive early breast cancer in terms of DFS, adverse effects and prevention of contralateral breast cancer. Howeve...
1
Dual-Sampling Attention Network for Diagnosis of COVID-19 From Community Acquired Pneumonia
Coronavirus Disease 2019 (COVID-19)
The coronavirus disease (COVID-19) is rapidly spreading all over the world, and has infected more than 1,436,000 people in more than 200 countries and territories as of April 9, 2020. Detecting COVID-19 at early stage is essential to deliver proper healthcare to the patients and also to protect the uninfected populatio...
0
Real-time knee adduction moment feedback training using an elliptical trainer
OAK 3 - Non-arthroplasty tx of OAK
The external knee adduction moment (EKAM) is associated with knee osteoarthritis (OA) in many aspects including presence, progression, and severity of knee OA. Despite of its importance, there is a lack of EKAM estimation methods that can provide patients with knee OA real-time EKAM biofeedback for training and clinica...
0
Arthroscopic pullout repair of a complete radial tear of the tibial attachment site of the medial meniscus posterior horn
AMP (Acute Meniscal Pathology)
We developed an effective arthroscopic pullout technique for repairing complete radial tears of the tibial attachment site of the medial meniscus posterior horn (MMPH). In our technique, the torn meniscus is reattached to the tibial plateau immediately medial or anteromedial to the posterior cruciate ligament (PCL) usi...
1
Short Versus Long Cephalomedullary Nails for Pertrochanteric Hip Fracture
Hip Fx in the Elderly 2019
This study compared patients who underwent treatment with short or long cephalomedullary nails with integrated cephalocervical screws and linear compression. Patients with AO/OTA 31-A2 or A3 pertrochanteric fractures treated with either short (n=72) or long (n=97) InterTAN (Smith & Nephew, Memphis, Tennessee) cephalome...
0
Multivariate analysis of factors related to radiographic knee osteoarthritis based on the comparison between football players and matched nonsportsmen
OAK 3 - Non-arthroplasty tx of OAK
PURPOSE: Knee osteoarthritis (KOA) is the most common joint pathology worldwide and a major cause of later disability. It is unknown if the bone mass density (BMD) is correlated with KOA. This study aimed to investigate the prevalence of radiographic KOA among retired professional football players by comparing with mat...
1
Microbiological evaluation of osteomyelitis with a special reference to antibiotic sensitivity pattern of isolates from a tertiary care hospital
DoD SSI (Surgical Site Infections)
Epidemiological change in osteomyelitis had been observed for the past few years with a significant rise of chronic osteomyelitis by multidrug-resistant organisms (MDROs). It complicates antibiotic selection, and if not managed adequately, it results in amputation, sepsis, or death. This study was conducted for one yea...
0
Does clinical rehabilitation impose sufficient cardiorespiratory strain to improve aerobic fitness?
DoD LSA (Limb Salvage vs Amputation)
OBJECTIVE: To investigate the cardiorespiratory strain experienced by patients over a day and during different types of rehabilitation therapies during a clinical rehabilitation programme. In addition, to investigate the use of the Borg scale as an instrument to monitor exercise intensity. DESIGN: An observational, cro...
0
Risk factors for second hip fractures among elderly patients
Management of Hip Fractures in the Elderly
BACKGROUND: Hip fractures following falls by the elderly, which increase with age, are increasing in number annually. The incidence of refracture (second hip fractures) has been reported to be 5%-10% in Japan and is expected to increase with the aging of the population in the future. Therefore, through a retrospective ...
0
Adaptation six months after multiple trauma: a pilot study
DoD PRF (Psychosocial RF)
This pilot study investigated the functional and psychosocial adaptation of 18 survivors of multiple trauma who were in the home setting 6 months after discharge from a tertiary trauma center. Seventeen subjects reported complete functional independence and one reported the need for assistance with self-care activities...
0
Nitric oxide pathway genes (NOS1AP and NOS1) are involved in PTSD severity, depression, anxiety, stress and resilience
DoD PRF (Psychosocial RF)
The nitric oxide pathway in the hippocampus is involved in the biological stress response with detrimental consequences to cells and HPA axis feedback. Hippocampal atrophy and HPA axis feedback dysfunction are associated with posttraumatic stress disorder (PTSD). This study systematically investigates two genes of the ...
0
Regenerative biomaterials: a review
Acellular Dermal Matrix
The authors present a review of biomaterials, substances traditionally derived from human or animal tissue or, more recently, biodegradable synthetics modeled after naturally occurring resources. These constructs differ from purely synthetic materials in that they are degraded or incorporated into a host's tissue. Thes...
0
Augmentation of the atrophic mandible with interposed bone grafts and particulate hydroxylapatite
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
The use of hydroxylapatite mixed with autogenous bone to augment the area posterior to the mental foramen is described. This method is combined with an interposed bone graft technique in the symphyseal area. The clinical implications are discussed in relation to potential nerve damage, height to be gained, and effects ...
1
Spaghetti wrist trauma: functional recovery, return to work, and psychological effects
DoD PRF (Psychosocial RF)
BACKGROUND: Few studies on spaghetti wrist trauma have been published. The study populations have all consisted of small numbers of patients, and most studies have focused on functional recovery. In addition, different definitions of this injury have been used. The objective of this study was to assess outcome for a la...
0
Embolization of pelvic arterial injury is a risk factor for deep infection after acetabular fracture surgery
DoD SSI (Surgical Site Infections)
OBJECTIVE: To determine whether embolization of pelvic arterial injuries before open reduction and internal fixation (ORIF) of acetabular fractures is associated with an increased rate of deep surgical site infection. METHODS: Retrospective review of patients who underwent ORIF of acetabular fractures at our institutio...
1
Continuous infiltration of local anaesthetic following total knee arthroplasty
Surgical Management of Osteoarthritis of the Knee CPG
PURPOSE: To determine whether continuous infiltration of local anaesthetic can reduce the pain score and morphine use over 48 hours after total knee arthroplasty (TKA). METHODS: 11 men and 43 women aged 50 to 82 years who underwent unilateral TKA for osteoarthritis were recruited. They were randomised into 3 groups. In...
0
The spherocentric knee: biomechanical testing and clinical trial
Surgical Management of Osteoarthritis of the Knee CPG
The spherocentric knee is a non-hinged, intrinsically stable knee-joint prosthesis which allows controlled triaxial rotation and was designed specifically for use in severely deformed or grossly unstable knees. Biomechanical evaluation of the prosthesis implanted in fresh human cadaver limbs demonstrated highly favorab...
0
Risk of falls increases with additional symptomatic osteoarthritic joints: The Johnston county osteoarthritis project
Surgical Management of Osteoarthritis of the Knee CPG
Background/Purpose: Falls, a growing problem among older adults, often lead to hospitalizations, surgeries, and death. Knee and hip osteoarthritis (OA) are known risk factors for falls, but whether they together additionally contribute to falls risk is unknown. This study utilizes a cohort of African American and Cauca...
0
Lumbar spondylosis, lumbar spinal stenosis, knee pain, back muscle strength are associated with the locomotive syndrome: Rural population study in Japan
OAK 3 - Non-arthroplasty tx of OAK
OBJECTIVES: To comprehensively investigate the clinical and physical factors associating with locomotive syndrome (Loc-S); the locomotorium-disability for daily life. METHODS: 647 volunteers participated (247 males, 400 females, Age: 58.4 +/- 11.0, BMI: 22.5 +/- 3.3). Three self-assessment questionnaires were administe...
0
Quadriceps muscle function after exercise in men and women with a history of anterior cruciate ligament reconstruction
OAK 3 - Non-arthroplasty tx of OAK
CONTEXT: Sex differences in lower extremity neuromuscular function have been reported after anterior cruciate ligament reconstruction (ACLR). Research evidence supports different levels of fatigability in men and women and between patients with ACLR and healthy controls. The influence of sex on the response to continuo...
1
Outcome Analysis of Lateral Pinning for Displaced Supracondylar Fractures in Children Using Three Kirschner Wires in Parallel and Divergent Configuration
Pediatric Supracondylar Humerus Fracture 2020 Review
BACKGROUND: Supracondylar humerus fracture is the most common fracture around elbow in children. Closed reduction and percutaneous Kirschner wire (pin) fixation is the standard method of managing displaced extension type (Gartland Type II and Type III) supracondylar humerus fractures. The configuration of wires is deba...
0
Infection in total joint replacements. Why we screen MRSA when MRSE is the problem?
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
A retrospective review of MRSA screening showed that of a total of 8911 patients screened pre-operatively between May 1996 and February 2001, 83 (0.9%) had MRSA isolated from one source or another. During the same period, 115 (13.6%) of 844 positive tissue samples taken during surgery grew Staphylococcus aureus. Of the...
0
The apparent incidence of hip fracture in Europe: a study of national register sources. MEDOS Study Group
Management of Hip Fractures in the Elderly
The objective of this study was to examine the apparent incidence of hip fracture from discharge rates in European countries. A request was sent to the Ministries of Health in all European countries, asking for the number of hip fracture patients by age and sex, between the years 1983 and 1985. Seventeen countries resp...
0
Phosphorylation of the SRC epithelial substrate Trask is tightly regulated in normal epithelia but widespread in many human epithelial cancers
MSTS 2018 - Femur Mets and MM
PURPOSE: The frequently elevated activities of the c-src and c-yes products in human epithelial tumors suggest that these activated tyrosine kinases have tumorigenic functions analogous to the v-src and v-yes oncogene products. Studies of v-src-transformed fibroblasts have identified many of the effectors of this poten...
1
Diabetic Control Predicts Surgical Site Infection Risk in Orthopaedic Trauma Patients
DoD SSI (Surgical Site Infections)
Objectives:(1) To determine the incidence of surgical site infections (SSIs) in diabetic orthopaedic trauma patients and (2) to establish a protocol for managing diabetes mellitus (DM) in orthopaedic trauma patients.Design:Retrospective cohort study.Setting:Level 1 Trauma Center.Patients:All diabetic orthopaedic trauma...
0
Metastatic tumours of bone
MSTS 2018 - Femur Mets and MM
Metastatic tumours of the bone are the most common types of bone cancer. Autopsy studies have shown that 70% of patients with breast and prostate carcinoma develop skeletal metastases. The most commonly involved bone sites are those with persistent red marrow, such as the vertebrae, proximal femur, ribs, sternum, pelvi...
0
Do Stemmed Tibial Components in Total Knee Arthroplasty Improve Outcomes in Patients With Obesity?
OAK 3 - Non-arthroplasty tx of OAK
Background: Recent clinical studies have reported that patients with higher body mass index (BMI) are more likely to experience premature failure of total knee arthroplasty (TKA), lower knee scores, and perhaps more pain in the prosthetic joint. However, it is not known whether certain implant design features such as t...
0
Complications following an amputation
OAK 3 - Non-arthroplasty tx of OAK
In 2005 there were an estimated 1.6 million individuals in the United States living with limb loss. This number has been projected to more than double by 2050 to 3.6 million, making an understanding of management of the individual with amputation essential for the physiatrist. This article highlights common complicatio...
0
Role of magnetic resonance imaging in entrapment and compressive neuropathy--what, where, and how to see the peripheral nerves on the musculoskeletal magnetic resonance image: part 2. Upper extremity
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
The diagnosis of nerve entrapment and compressive neuropathy has been traditionally based on the clinical and electrodiagnostic examinations. As a result of improvements in the magnetic resonance (MR) imaging modality, it plays not only a fundamental role in the detection of space-occupying lesions, but also a compensa...
0
Serum Concentrations and Pharmacokinetics of Tranexamic Acid after Two Means of Topical Administration in Massive Weight Loss Skin-Reducing Surgery
Copy of Panniculectomy & Abdominoplasty CPG
BACKGROUND: Topical administration of tranexamic acid to reduce bleeding is receiving increasing attention, as it is inexpensive, simple, and possibly beneficial in most surgery. Concerns regarding potential systemic adverse effects such as thromboembolic events and seizures may prevent general use of tranexamic acid. ...
0
Clinical study on effect of dexamethasone in preventing fat embolism syndrome after cemented hip arthroplasty
AAHKS (2) Corticosteroids
METHODS: Forty patients scheduled for unilateral cemented hip arthroplasty between January 2008 and December 2009 were randomly divided into trial group (n = 20) and control group (n = 20). In trial group, there were 6 males and 14 females with an average age of 73.2 years (range, 54�95 years), including 4 cases of o...
0
Factors related to outcome of early and delayed prosthetic joint infections
PJI DX Updated Search
In this prospective study, we evaluate the impact of adherence to a diagnostic and therapeutic protocol on prosthetic joint infections (PJI) diagnostic accuracy and outcome. Patients and methods: Patients with early or delayed PJI referred over a 5-year period were included. Diagnosis was based on characteristic clinic...
0
Electrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis
SR for PM on OA of All Extremities
OBJECTIVE: To investigate the efficacy of different electrical stimulation (ES) therapies in pain relief of patients with knee osteoarthritis (OA). METHOD: Electronic databases including MEDLINE, Embase and Cochrane Library were searched through for randomized controlled trials (RCTs) comparing any ES therapies with co...
0
Treatment of vascular injuries associated with limb fractures
DoD LSA (Limb Salvage vs Amputation)
INTRODUCTION: The goal of therapy in all patients with combined orthopaedic and vascular injuries of the extremities is salvage of a functional limb. In this study, we have evaluated our experience with a subset of patients who had a combination of vascular injury and limb fracture. PATIENTS AND METHODS: The records of...
0
Adductor Canal Block and Recovery After Total Knee Replacement Surgery
AAHKS (9/10) Regional Nerve Blocks
The period after total knee replacement (TKR) surgery is known to be painful for the first 24 hours, lasting up to 3 days in many cases. Successful management of pain after TKR is regarded as necessary to early recovery, rehabilitation and timely discharge. Severe pain following major joint arthroplasty can hinder earl...
0
The aggregation of human platelets by Lactobacillus species
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
The ability to aggregate human platelets was examined for five Lactobacillus rhamnosus strains and five Lactobacillus paracasei subsp. paracasei strains isolated from patients with infective endocarditis (IE), 25 laboratory isolates from the same two species, and 14 strains from five other oral species, namely Lactobac...
0
Amyloid deposits in surgically removed articular and periarticular tissue
AMP (Acute Meniscal Pathology)
In tissue from 13 of 30 patients subjected to meniscectomy, amyloid degeneration was found to varying extent along the surface of the meniscus. Tissue from 30 synovectomies, 30 bursectomies and 30 ganglia showed amyloid deposits in four, six and eight cases, respectively. Amyloid was found significantly more frequently...
0
A model of osteoporosis impact in Switzerland 2000-2020
HipFx Supplemental Cost Analysis
The aim of our study was to develop a modeling framework suitable to quantify the incidence, absolute number and economic impact of osteoporosis-attributable hip, vertebral and distal forearm fractures, with a particular focus on change over time, and with application to the situation in Switzerland from 2000 to 2020. ...
0
Traumatic injuries of the distal femoral physis. Retrospective study on 151 cases
DOD - Acute Comp Syndrome CPG
This is a retrospective study on a series of 151 injuries involving the distal femoral physis. The average age at the time of injury was 12.3 years. Patients were followed for an average of 8.2 years. The complications encountered were not insignificant and the satisfactory results were relatively low (64.9%). The juve...
0
T1rho MRI of human musculoskeletal system
AMP (Acute Meniscal Pathology)
Magnetic resonance imaging (MRI) offers the direct visualization of the human musculoskeletal (MSK) system, especially all diarthrodial tissues including cartilage, bone, menisci, ligaments, tendon, hip, synovium, etc. Conventional MRI techniques based on T1 - and T2 -weighted, proton density (PD) contrast are inconclu...
0
Nitrous oxide does not impair hepatic function in young or old surgical patients
AAHKS (8) Anesthetic Infiltration
We investigated whether anesthesia including nitrous oxide (N2O) caused hepatic injury, and whether any adverse effect of N2O was affected by patient age. One hundred patients having total hip replacements were randomly assigned to a regimen that included or excluded N2O (50%-60%) during regional anesthesia supplemente...
0
Adipose Mesenchymal Stromal Cell-Based Therapy for Severe Osteoarthritis of the Knee: A Phase I Dose-Escalation Trial
PRP (Platelet-Rich Plasma)
: Osteoarthritis (OA) is the most widespread musculoskeletal disorder in adults. It leads to cartilage damage associated with subchondral bone changes and synovial inflammation, causing pain and disability. The present study aimed at evaluating the safety of a dose-escalation protocol of intra-articular injected adipos...
0
Reduced opioid prescribing following arthroscopic meniscectomy does not negatively impact patient satisfaction
AMP (Acute Meniscal Pathology)
BACKGROUND: Prior research has demonstrated that physician desire to optimize patient satisfaction is a cause of over-prescription of opioid medications in the healthcare setting. The purpose of this study was to investigate what effect, if any, decreased opioid prescribing following arthroscopic meniscectomy had on Pr...
0
Surgical management of auricular defect depending on the size, location, and tissue involved
Reconstruction After Skin Cancer
PURPOSE: Auricular reconstruction is a challenging surgical intervention that requires perfect surgical skills, exact planning, and esthetic knowledge. It is necessary to use a suitable method of reconstruction for each patient. From 10 years of experience, the authors have developed a general concept for auricular rec...
0
All-terrain vehicle injuries in children: injury patterns and prognostic implications
DoD LSA (Limb Salvage vs Amputation)
BACKGROUND: All-terrain vehicle (ATV) accidents are common in children. Our purpose was to identify imaging patterns associated with ATV injuries in children. PATIENTS AND METHODS: The study group comprised 141 consecutive children admitted to a tertiary pediatric hospital following ATV accidents. Medical records were ...
0
Tuberculosis presenting as carpal tunnel syndrome
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
A 44-year-old man presented with typical symptoms, signs, and laboratory findings of carpal tunnel syndrome. Mycobacterium tuberculosis was cultured from the flexor tenosynovium excised at surgery. Tuberculosis should be considered in the differential diagnosis of carpal tunnel syndrome with unexplained chronic synovit...
0
Costs and quality of life associated with osteoporosis-related fractures in Sweden
Management of Hip Fractures in the Elderly
This prospective observational data collection study assessed the cost and quality of life related to hip, vertebral and wrist fracture 1 year after the fracture, based on a patient sample consisting of 635 male and female patients surviving a year after fracture. Data regarding resource use and quality of life related...
1
Treatment of open proximal femoral fractures sustained in combat
DoD LSA (Limb Salvage vs Amputation)
Background: Open proximal femoral fractures are rare injuries that often result from wartime high-energy causes. Limited data exist regarding the treatment and complications of these injuries. Methods: We retrospectively reviewed the records of combat casualties treated at two institutions between March 2003 and March ...
0
Anterolateral Approach for Distal Third Humeral Shaft Fractures: A Surgical Approach Using 3 Soft-tissue Windows
Pediatric Supracondylar Humerus Fracture 2020 Review
An anterolateral approach is described for the treatment of distal third humeral shaft fractures. The approach using 3 soft-tissue windows combines an anterior brachialis muscle splitting approach, a muscle interval exposure of the radial nerve between the brachialis and brachioradialis muscles, and a lateral exposure ...
0
Prospective outcome study of 106 cases of vertical mastopexy, augmentation/mastopexy, and breast reduction
Reduction Mammoplasty for Female Breast Hypertrophy
BACKGROUND: Patient-reported data, including effects on patient satisfaction and quality of life, have not been rigorously studied in women treated with mastopexy and augmentation/mastopexy. This prospective outcome study evaluates and compares mastopexy (n=36), augmentation/mastopexy (n=47), and reduction (n=20) from ...
0
Hip fracture in a patient affected by transient osteoporosis of the femoral head during the last trimester of pregnancy
PJI DX Updated Search
Few cases of hip fracture in pregnant women affected by transient osteoporosis of the femoral head have been reported in the literature, but its real incidence seems to be underestimated. During pregnancy, osteoporosis manifests itself with an insidious onset of hip pain and limp without any trauma or infective episode...
0
Continuous spinal anaesthesia or continuous epidural anaesthesia for post-operative pain control after hip replacement?
AAHKS (8) Anesthetic Infiltration
Both continuous spinal anaesthesia and continuous epidural anaesthesia are supposed to provide adequate post-operative pain relief. The purpose of this randomized, prospective study was to compare the quality of analgesia, occurrence of side effects and patient satisfaction between spinal and epidural administration of...
0
The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D
MSTS 2018 - Femur Mets and MM
The hormonal form of vitamin D, 1 alpha,25-dihydroxyvitamin D [1 alpha,25(OH)(2)D] promotes the differentiation and inhibits the proliferation, invasiveness and metastasis of prostate cells. However, 1 alpha,25(OH)(2)D is not suitable as a chemopreventive agent because its administration can cause hypercalcemia. Serum ...
0
Oropharyngeal candidiasis in patients with hematological immunosuppression. A pilot study
Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures
OBJECTIVE: The purpose of this study was to investigate the clinical forms of oral candidiasis (OC) in patients with hematological immunosuppression
1
External fixation is more suitable for intra-articular fractures of the distal radius in elderly patients
DoD SSI (Surgical Site Infections)
The purpose of this study was to compare the functional outcomes, psychological impact, and complication rates associated with external fixation and volar or dorsal plating in relation to the functional parameters following treatment of intra-articular fractures of the distal radius (IFDR) in patients older than 65 yea...
0
Drug assessment by a Pharmacy and Therapeutics committee: From drug selection criteria to use in clinical practice
MSTS 2018 - Femur Mets and MM
Background: In Spain, hospital medicines are assessed and selected by local Pharmacy and Therapeutics committees (PTCs). Of all the drugs assessed, cancer drugs are particularly important because of their budgetary impact and the sometimes arguable added value with respect to existing alternatives. This study analyzed ...
0
Cementless total hip arthroplasty in the treatment of severe hip dysplasia or dislocated hips
Management of Hip Fractures in the Elderly
We present our experience over 6 years with the use of uncemented total hip arthroplasty (THA) for developmental dysplasia of the hip (DDH) with a mean follow-up of 3 years. In a 6-year period, 26 THAs were performed in 19 patients with Hartofilakidis grades 2 and 3 dislocation of the hips. Out of 19 patients, seven ha...
0
Phase 1, Dose Escalation Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SM04690 in Moderate to Severe Knee Osteoarthritis (OA)
OAK 3 - Non-arthroplasty tx of OAK
The purpose of this study is to find the optimal dose of SM04690 that can be safely given by intra�articular injection into the target knee joint of subjects with moderate to severe osteoarthritis.
0
A 6 year old girl with bilateral foot drop
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
A 6 year old girl-the product of a 35 week twin delivery- had a 2.5 week stay in the NICU for respiratory and feeding difficulties, but then had a benign neonatal course. She reached her milestones on time and walked at 13 months. She did not toe walk, but had difficulty hopping. At 3.5 years, she tripped while climbin...
0
Reverse total shoulder replacement for nonunion of a fracture of the proximal humerus
Hip Fx in the Elderly 2019
Patients with pain and loss of shoulder function due to nonunion of a fracture of the proximal third of the humerus may benefit from reverse total shoulder replacement. This paper reports a prospective, multicentre study, involving three hospitals and three surgeons, of 35 patients (28 women, seven men) with a mean age...
1
Motor-sparing effect of iPACK (interspace between the popliteal artery and capsule of the posterior knee) block versus tibial nerve block after total knee arthroplasty: A randomized controlled trial
AAHKS (8) Anesthetic Infiltration
Background and objective: An ultrasound-guided anesthetic technique targeting the interspace between the popliteal artery and capsule of the posterior knee (iPACK) can provide posterior knee analgesia with preserved motor function after total knee arthroplasty (TKA). This study compared the peroneal nerve motor-sparing...
0
Endoscopic compartment release for chronic exertional compartment syndrome
DOD - Acute Comp Syndrome CPG
Exertional compartment syndrome of the leg is a condition that can cause chronic debilitating pain in active persons during a variety of aerobic activities. Nonoperative treatments using stretching protocols and activity modifications are often unsuccessful, and thus several operative strategies have been used to treat...
0
Colles' fracture treated with non-bridging external fixation: a 1-year follow-up
Distal Radius Fractures
The results in 75 of 105 patients with Older type II/III (AO type A2.2, A3.1, A3.2) Colles' fractures, treated with non-bridging external fixation are presented. The mean age was 67.8 years, and all patients were followed prospectively for 12 months with radiological and functional assessment. No statistically signific...
0
Distribution of cortical bone in the femoral neck and hip fracture: A prospective case-control analysis of 143 incident hip fractures; the
Management of Hip Fractures in the Elderly
In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in...
0
Percutaneous Acetabuloplasty for Metastatic Lesions to the Pelvis
Hip Fx in the Elderly 2019
Metastatic lesions of the acetabulum can be painful and debilitating. First-line treatment is multimodal and consists of disease-specific chemotherapy, osteoclastic inhibitors, analgesics, and radiation therapy. When these therapies fail, surgical intervention usually is indicated and varies from regional defect stabil...
0
Effect of day of the week of primary total hip arthroplasty on length of stay at a university-based teaching medical center
PJI DX Updated Search
Length of hospital stay (LHS) after primary total hip arthroplasty (THA) constitutes a critical outcome measure, as prolonged LHS implies increased resource expenditure. Investigations have highlighted factors that affect LHS after THA. These factors include advanced age, medical comorbidities, obesity, intraoperative ...
1
Vitamin B6 levels in patients with carpal tunnel syndrome
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
Vitamin B6 levels were determined in patients with idiopathic carpal tunnel syndrome. Results from this limited study strongly suggest that vitamin B6 deficiency may accompany carpal tunnel syndrome. This study did not address the question of the causal relationship between vitamin B6 status and development of symptoms
1
Intercalary bone segment transport in treatment of segmental tibial defects
DoD LSA (Limb Salvage vs Amputation)
Objective: To evaluate the results and complications of intercalary bone segment transport in the treatment of segmental tibial defects. Design: This is a retrospective analysis of patients with segmental tibial defects who were treated with intercalary bone segment transport method. Place and Duration of Study: The st...
0
The effects of surface roughness and type of denture acrylic on biofilm formation by Streptococcus oralis in a constant depth film fermentor
Dental Implant Infection
AIMS: To investigate the effects of surface roughness and type of denture acrylic on the early development of a Streptococcus oralis biofilm in a constant depth film fermentor (CDFF)., METHODS AND RESULTS: Streptococcus oralis was incubated with acrylic of known surface roughness in the CDFF. Adherent Strep. oralis wer...
0
Prevalence of fractures in women with rheumatoid arthritis and/or systemic lupus erythematosus on chronic glucocorticoid therapy Epidemiology of musculoskeletal disorders
Hip Fx in the Elderly 2019
Background: Glucocorticoid (GC) therapy is associated with an increased risk of fractures. The main objective of this study was to determine the prevalence of undiagnosed vertebral fractures in women chronically using GC therapy for autoimmune disorders. We also determined the prevalence of non-vertebral fractures, and...
0
Evaluation of Gait Speed after Applying Kinesio Tape on Quadriceps Femoris Muscle in Patients with Knee Osteoarthritis
OAK 3 - Non-arthroplasty tx of OAK
BACKGROUND: Knee osteoarthritis is a chronic degenerative disease, known as the most common cause of difficulty walking in older adults and subsequently is associated with slow walking. Functional decline, increased risk of falls and the presence of pain are, in many studies, related to the muscle weakness caused by os...
0
Comparison of radiographic alignment of imageless computer-assisted surgery vs conventional instrumentation in primary total knee arthroplasty
Surgical Management of Osteoarthritis of the Knee CPG
A total of 208 patients were enrolled in a multicenter, prospective randomized, institutional review board-approved study that compared preoperative surgical plan to postoperative 2-dimensional radiographic alignment measured by a blinded reviewer for primary total knee arthroplasty (TKA) implanted using computer-assis...
0
Mitochondrial dysfunction affecting visual pathways
Upper Eyelid and Brow Surgery
Mitochondrial dysfunction leads to cellular energetic impairment, which may affect the visual pathways, from the retina to retrochiasmal structures. The most common mitochondrial optic neuropathies include Leber's hereditary optic neuropathy and autosomal dominant optic atrophy, but the optic nerve can be affected in o...
0
The KNEEhabilitation Study: improving Disability in Individuals With Knee Osteoarthritis
OAK 3 - Non-arthroplasty tx of OAK
The focus of this project is to use transcutaneous electrical nerve stimulation (TENS) for the novel indication of treating neuromuscular activation in individuals with knee osteoarthritis (OA) that exhibit neuromuscular activation deficits. The overall goal is to improve outcomes associated traditional therapeutic exe...
0
Minimally displaced pediatric humerus lateral condyle fractures: risk factors for displacement and outcomes of delayed surgery
Pediatric Supracondylar Humerus Fracture 2020 Review
The purpose of this study was to identify risk factors for management failure in pediatric minimally displaced lateral condyle fractures of the distal humerus (LCHFx) and compare outcomes between initial nonoperative and operative cohorts. A retrospective chart review of LCHFx was conducted to identify children treated...
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Internal fixation of diaphyseal fractures of the forearm by interlocking intramedullary nail: short-term results in eighteen patients
DoD SSI (Surgical Site Infections)
OBJECTIVE: This study was designed to evaluate the efficacy of the treatment of diaphyseal fractures of the forearm using the ForeSight forearm interlocking intramedullary nail. DESIGN: Retrospective study. SETTING: University-affiliated teaching hospital. PATIENTS: Eighteen patients with 32 displaced diaphyseal forear...
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Ipsilateral femoral neck and shaft femur fracture in a child: Nonoperative manag
Pediatric Diaphyseal Femur Fractures 2020 Review
Concomitant ipsilateral fractures of the neck and shaft of femur are a rare occurrence in childhood. Only 14 cases have been reported to date, the most common fracture pattern being Delbet Type III and a spiral fracture of midshaft femur. A four-year-old boy presented with closed fracture shaft femur and chest trauma (...
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Linked elbow replacement: a salvage procedure for distal humeral nonunion. Surgical technique
The Treatment of Pediatric Supracondylar Humerus Fractures AUC
BACKGROUND: Nonunion is a challenging and not uncommon complication of distal humeral fractures. Our long-term experience with linked semiconstrained total elbow arthroplasty as a salvage procedure for patients with distal humeral nonunion not amenable to internal fixation was investigated. METHODS: Ninety-one consecut...
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Revision Total Knee Arthroplasty with Metaphyseal Sleeves without Stem: Short-Term Results
OAK 3 - Non-arthroplasty tx of OAK
<b>Purpose</b> The aim of this study was to evaluate the efficacy of revision total knee arthroplasty (TKA) with cementless metaphyseal sleeves without stems either in the femoral or tibial side or in both. <b>Methods</b> In this retrospective study, 51 patients (51 knees) operated in the period 2010 to 2015 met the ab...
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Ipsilateral fibular transposition in tibial nonunion using Huntington procedure: a 12-year follow-up study
DoD LSA (Limb Salvage vs Amputation)
Eleven patients (10 men and 1 woman) with a mean age of 32 years (range: 16-61 years) and a mean follow-up of 12 years (range: 2-21 years) were studied retrospectively after ipsilateral fibular transposition. The cause of tibial nonunion was a motor vehicle collision (MVC) in eight patients, a fall from a window in one...
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Perioperative systemic glucocorticoids in total hip and knee arthroplasty: A systematic review of outcomes
AAHKS (5) Gabapentinoids
BACKGROUND: Perioperative systemic glucocorticoids are frequently included in multimodal analgesia and antiemetic regimens administered to patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA). The objective of this systematic review was to evaluate the available randomized controlled trial...
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A comparison of the efficacy and rate of response to oral and intravenous Vitamin K in reversal of over-anticoagulation with warfarin
Management of Hip Fractures in the Elderly
The role of oral Vitamin K administration in the reversal of anticoagulation is not yet clear because of a paucity of data on the early effects of treatment, apparent differences in efficacy between preparations and a lack of data comparing oral with intravenous administration. We have compared the effects on the Inter...
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Primary metal-on-metal total hip arthroplasty with large-diameter femoral heads: a clinical trial of 59 hips
PJI DX Updated Search
Large-diameter femoral heads with nearly anatomical sizes became available for metal-on-metal total hip arthroplasty after recent advances in metal-on-metal technology. We retrospectively studied the clinical and radiological results in 59 hips of 54 patients (32 women and 22 men, mean age 54.4 years) who underwent cem...
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Proximal femoral nail versus dynamic hip screw fixation for trochanteric fractures: a meta-analysis of randomized controlled trials
DoD SSI (Surgical Site Infections)
BACKGROUND: The purpose of this meta-analysis was to find out whether the proximal femoral nail was better than the dynamic hip screw in the treatment of trochanteric fractures with respect to operation time, blood transfusion, hospital stay, wound complications, number of reoperation, and mortality rate. METHODS: All ...
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Pick-up test: an indication for opponensplasty in patients with severe carpal tunnel syndrome
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
PURPOSE: To use a pick-up test to assess thenar motor deficit and results of opponensplasty. METHODS: Eight consecutive patients with idiopathic severe carpal tunnel syndrome and severe thenar motor deficit were identified. All were females aged 39 to 60 (mean, 53) years and right-hand dominant. The severity of thenar ...
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Clinical outcome following surgical intervention for periprosthetic hip fractures at a tertiary referral centre
PJI DX Updated Search
Complications following surgical intervention for periprosthetic hip fractures are not uncommon. We report the clinical outcome following definitive surgical intervention for this indication at a single tertiary referral centre. All patients admitted between 2003 and 2009 undergoing such treatment were included. Patien...
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Uninterrupted perioperative clopidogrel and bleeding-related events after total joint arthroplasty: a case series
PJI DX Updated Search
There is a known bleeding risk with administration of the antiplatelet drug clopidogrel, but in certain patients the likelihood of thrombosis is too high to cease its administration perioperatively. The risks of performing total joint arthroplasty in this population are unknown. An inpatient pharmacy database query ide...
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The association between radiographic severity and pre-operative function in patients undergoing primary knee replacement for osteoarthritis
Surgical Management of Osteoarthritis of the Knee CPG
OBJECTIVE: To determine the association between radiographic osteoarthritis (OA) and pre-operative function in patients undergoing primary knee replacement. METHODS: Single centre study examining pre-operative outcomes in a consecutive series of 525 patients who underwent primary knee replacement for OA between January...
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Predicting the outcome of revision carpal tunnel release
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
PURPOSE: To test the hypothesis that the result of steroid injection in the carpal tunnel in a patient with recurrent carpal tunnel symptoms would serve as a good predictor of the outcome of later carpal tunnel release (CTR). METHODS: We conducted a retrospective review of all patients who underwent revision CTR for re...
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Surgical management of carpal tunnel syndrome in neurosurgery practice in Ethiopia and review of literature
Diagnosis and Treatment of Carpal Tunnel Syndrome CPG
Carpal tunnel compression of the median nerve is a common condition with an estimated incidence of 0.1% to 10% and a direct medical cost of above dollars 1 billion per year in the USA. Between the years 1995 to 2002, 28 cases, 6 (21.4%) males and 22 (87.6%) females of mild to severe forms of carpal tunnel syndrome (CTS...
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Cemented versus cementless fixation of a tibial component in LCS mobile-bearing total knee arthroplasty performed by a single surgeon
OAK 3 - Non-arthroplasty tx of OAK
Although cemented tibial fixation of total knee arthroplasty accepted as the gold standard, cementless fixation as a means to supplement disadvantages of cemented fixation continues to be of interest to clinicians. One hundred sixty-eight consecutive knees undergoing primary knee arthroplasty for osteoarthritis were ra...
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The Ilizarov external fixator - A useful alternative for the treatment of proximal tibial fractures A prospective observational study of 30 consecutive patients
DOD - Acute Comp Syndrome CPG
Background: In dislocated proximal tibial fractures, the most frequently used treatment is ORIF with screws and plates. Minimally-invasive techniques using external fixation are an alternative. The aim of this study was to analyse the clinical and radiological results using the Ilizarov technique in both uni- and bicon...
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Site-specific variation in the classification of osteoporosis, and the diagnostic reclassification using the lowest individual lumbar vertebra T-score compared with the L1-L4 mean, in early postmenopausal women
Management of Hip Fractures in the Elderly
In this study we report first the concordance and variation in diagnostic osteoporosis classification using multiple skeletal site measurements compared with the lumbar spine only; and secondly, at the lumbar spine, the variation and diagnostic osteoporosis reclassification using the lowest individual vertebra T-score ...
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Pediatric femoral shaft fractures treated by flexible intramedullary nailing
Pediatric Diaphyseal Femur Fractures 2020 Review
Background Nowadays pediatric femoral fractures are more commonly managed with operative treatment rather than conservative treatment because of more rapid recovery and avoidance of prolonged immobilization. Children between the ages of 5-13 years are treated either by traction plus hip spica and flexible/elastic stabl...