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0 | Putting the baby back in the bathwater: The interpretation of randomised trials in surgery | Glenohumeral Joint OA | Recently, several high impact randomised controlled trials have been published suggesting no greater benefit from orthopaedic surgery over conservative treatment, or limited surgical intervention. These studies can have profound effects on clinical practice, leading to the abandonment of previously widely-used operatio... |
0 | Early Revision Surgery for Tibial Plateau Non-union and Mal-union | OAK 3 - Non-arthroplasty tx of OAK | BACKGROUND: Although relatively rare, non-unions and mal-unions of tibial plateau fractures present significant challenges for the orthopedic surgeon. With careful pre-operative planning, tibial plateau mal-union or non-union revision surgery with intra-articular and varus opening osteotomies can provides good function... |
0 | Optimization strategies on the structural modeling of gelatin/chitosan scaffolds to mimic human meniscus tissue | AMP (Acute Meniscal Pathology) | Meniscus lesions are frequently occurring injuries with poor ability to heal. Typical treatment procedure includes removal of damaged regions, which can lead to sub-optimal knee biomechanics and early onset of osteoarthritis. Some of the drawbacks of current treatment approach present an opportunity for a tissue engine... |
1 | Beyond the Hernia Repair: A Review of the Insurance Coverage of Critical Adjuncts in Abdominal Wall Reconstruction | Panniculectomy & Abdominoplasty CPG | The prevalence of complex abdominal wall defects continues to rise, which necessitates increasingly sophisticated medical and surgical management. Insurance coverage for reconstructive surgery varies due to differing interpretations of medical necessity. The authors sought to characterize the current insurance landscap... |
0 | Unipolar versus bipolar hemiarthroplasty for displaced femoral neck fractures: A pooled analysis of 30,250 participants data | DoD SSI (Surgical Site Infections) | Purpose: To assess the clinical outcomes of unipolar versus bipolar hemiarthroplasty for displaced intracapsular femoral neck fractures in older patients and to report whether bipolar implants yield better long-term functional results. Methods: We searched PubMed, Scopus, EBSCO, and Cochrane Library for relevant random... |
1 | Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study | OAK 3 - Non-arthroplasty tx of OAK | BACKGROUND: We previously developed a surface-controlled water-dispersible form of curcumin and named it Theracurmin() (Theracurmin; Theravalues, Tokyo, Japan). The area under the blood concentration-time curve of Theracurmin in humans was 27-fold higher than that of curcumin powder. We determined the clinical effects ... |
0 | Interventions for promoting physical activity | SR for PM on OA of All Extremities | Background: Little is known about the effectiveness of strategies to enable people to achieve and maintain recommended levels of physical activity.Objectives: To assess the effectiveness of interventions designed to promote physical activity in adults aged 16 years and older, not living in an institution.Search methods... |
0 | Management of recurrent, complex instability of the elbow with a hinged external fixator | DoD SSI (Surgical Site Infections) | We have treated 16 patients with recurrent complex elbow instability using a hinged external fixator. All patients had instability, dislocation or subluxation of the ulnohumeral joint. The injuries were open in eight patients and were associated with 20 other fractures and five peripheral nerve injuries. Two patients h... |
1 | Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery | Surgical Management of Osteoarthritis of the Knee CPG | BACKGROUND: Blood conservation strategies have been developed to diminish blood transfusion requirements in patients undergoing hip or knee replacement surgery. Tranexamic acid (TA) is an inexpensive antifibrinolytic agent that is little used in orthopaedic surgery due to the absence of standardised optimal administrat... |
0 | Neuropathy and myopathy in primary Sjogren's syndrome: neurophysiological, immunological and muscle biopsy results | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | Seventeen consecutive patients with primary Sjogren's syndrome (PSS) received neurophysiological examination, analysis of antibodies against peripheral nerve-myelin (PNM) and muscle biopsy, to show the prevalence and characteristics of peripheral neuropathy (PN) and myopathy; 3 PSS cases showed a clinical mild sensorim... |
0 | Progression of Hip Dysplasia in Mucopolysaccharidosis Type I Hurler After Successful Hematopoietic Stem Cell Transplantation | Developmental Dysplasia of the Hip 2020 Review | BACKGROUND: Dysostosis multiplex contributes substantially to morbidity in patients with Hurler syndrome (mucopolysaccharidosis type I Hurler phenotype [MPS I-H]), even after successful hematopoietic stem cell transplantation (HSCT). One of the hallmarks of dysostosis multiplex in MPS I-H is hip dysplasia, which often ... |
0 | Gene-based GWAS and biological pathway analysis of the resilience of executive functioning | DoD PRF (Psychosocial RF) | Resilience in executive functioning (EF) is characterized by high EF measured by neuropsychological test performance despite structural brain damage from neurodegenerative conditions. We previously reported single nucleotide polymorphism (SNP) genome-wide association study (GWAS) results for EF resilience. Here, we rep... |
1 | Static magnetic field therapy for carpal tunnel syndrome: a feasibility study | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | OBJECTIVES: To assess the feasibility of conducting trials of static magnetic field (SMF) therapy for carpal tunnel syndrome (CTS), to collect preliminary data on the effectiveness of 2 SMF dosages, and to explore the influence of an SMF on median nerve conduction. DESIGN: Randomized, double-blind, sham-controlled tria... |
0 | Pathophysiology and mechanisms of compartment syndrome | DOD - Acute Comp Syndrome CPG | Compartment syndrome is a serious potential complication of trauma to the extremities. Increases in intracompartmental tissue pressure result from increases in fluid pressure plus the contributions of cells, fibers, gels, and matrices. The result is an increased venous pressure that lowers the arteriovenous pressure gr... |
0 | Adverse soft-tissue reactions around non-metal-on-metal total hip arthroplasty - a systematic review of the literature | PJI DX Updated Search | Adverse local soft-tissue reactions have been associated with severe osteolysis and implant failure in metal-on-metal total hip arthroplasty (THA). Such a causal relationship has not often been associated with non metal-on-metal bearing surfaces. The purpose of this study was to assess the literature for cases of adver... |
0 | Magnetic Resonance Imaging Analysis of Peroneal Tendon Pathology Associated With Low-Lying Peroneus Brevis Muscle Belly: A Case-Control Study | Osteochondritis Dissecans 2020 Review | BACKGROUND: Low-lying peroneus brevis tendon muscle belly has been speculated to be an associated factor with symptomatic peroneal tendon pathology. Multiple studies have analyzed normal and anomalous anatomy associated with peroneal tendon pathology; however, no study has confirmed the clinical association between per... |
0 | Perfusion computed tomography in posterior circulation stroke: predictors and prognostic implications of focal hypoperfusion | Upper Eyelid and Brow Surgery | BACKGROUND AND PURPOSE: The aim was to determine the predictors of focal hypoperfusion on computed tomography (CT) perfusion (CTP) in patients with acute posterior circulation stroke and its association with long-term outcome. METHODS: Patients with posterior circulation stroke were selected from the Acute Stroke Regis... |
0 | Chemoprophylaxis against infective endocarditis following dental surgery | Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures | Patients with certain cardiovascular abnormalities are recognised to beat risk - and some at high risk - of developing infective endocarditis following episodes of bacteraemia. Whenever a clinically important bacteraemia is anticipated in such susceptible patients, chemoprophylaxis (use of systemic antimicrobials) is a... |
0 | True/Flex intramedullary nailing for forearm shaft fractures. Long-term results | Distal Radius Fractures | PURPOSE OF THE STUDY Presentation of technical experience and the clinical and functional results of intramedullary fixation of forearm shaft fractures. MATERIAL AND METHODS Between January 1994 and December 2009, a total of 96 patients with 144 radial and/or ulnar fractures (ulna, 33; radius,15; both, 48) were treated... |
1 | Clinical and Radiological Regeneration of Large and Deep Osteochondral Defects of the Knee by Bone Augmentation Combined With Matrix-Guided Autologous Chondrocyte Transplantation | Osteochondritis Dissecans 2020 Review | BACKGROUND: Large osteochondral defects of the knee are a challenge for regenerative treatment. While matrix-guided autologous chondrocyte transplantation (MACT) represents a successful treatment for chondral defects, the treatment potential in combination with bone grafting by cancellous bone or bone block augmentatio... |
0 | Are standard instruments valid for the assessment of quality of life and symptoms in glaucoma? | Upper Eyelid and Brow Surgery | PURPOSE: To determine if the impact of Visual Impairment Instrument (IVI) and Glaucoma Symptom Scale (GSS) are valid instruments to assess participation in daily living and ophthalmic complaints, respectively, in a glaucoma population. METHODS: Patients with glaucoma were recruited from private and public clinics and c... |
0 | Long-term efficacy and safety of ruxolitinib versus best available therapy in polycythaemia vera (RESPONSE): 5-year follow up of a phase 3 study | MSTS 2022 - Metastatic Disease of the Humerus | Background: Polycythaemia vera is a myeloproliferative neoplasm characterised by excessive proliferation of erythroid, myeloid, and megakaryocytic components in the bone marrow due to mutations in the Janus kinase 2 (JAK2) gene. Ruxolitinib, a JAK 1 and JAK 2 inhibitor, showed superiority over best available therapy in... |
0 | Parathyroid cancer: etiology, clinical presentation and treatment | MSTS 2018 - Femur Mets and MM | Parathyroid carcinoma (PC) is an uncommon finding, accounting for only 1-2% of patients with primary hyperparathyroidism (HPT), but a relatively higher incidence has been reported in Italy and Japan. The etiology of the tumour remains unclear, but molecular analysis studies have hypothesised the involvement of mutation... |
1 | Accuracy of routine magnetic resonance imaging in meniscal and ligamentous injuries of the knee: comparison with arthroscopy | Anterior Cruciate Ligament Injuries CPG | The aim of this study was to detect the accuracy of routine magnetic resonance imaging (MRI) done in different centres and its agreement with arthroscopy in meniscal and ligamentous injuries of the knee. We prospectively examined 70 patients ranging in age between 22 and 59 years. History taking, plain X-ray, clinical ... |
0 | Training with unilateral resistance exercise increases contralateral strength | The Treatment of Pediatric Supracondylar Humerus Fractures AUC | Evidence that unilateral training increases contralateral strength is inconsistent, possibly because existing studies have design limitations such as lack of control groups, lack of randomization, and insufficient statistical power. This study sought to determine whether unilateral resistance training increases contral... |
0 | Implant removal rate from infection after tibial plateau leveling osteotomy in dogs | PJI DX Updated Search | OBJECTIVE: To determine implant removal rate associated with infection after tibial plateau leveling osteotomy (TPLO) in dogs and to report antimicrobial susceptibility patterns for isolates. STUDY DESIGN: Retrospective case series. ANIMALS: Dogs (n = 255; 282 TPLO). METHODS: Medical records (April 2006-April 2008) for... |
0 | Antibiotic prophylaxis in total hip arthroplasty: Effects of antibiotic prophylaxis systemically and in bone cement on the revision rate of 22,170 primary hip replacements followed 0-14 years in the Norwegian Arthroplasty Register | Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures | We studied the effects of antibiotic prophylaxis, systemically and in bone cement, on the revision rate of cemented total hip arthroplasties (THAs) in data from the Norwegian Arthroplasty Register during the period 1987-2001. To have comparable groups, only THAs performed because of primary osteoarthritis, using cement... |
0 | Oxford phase III meniscal bearing fracture: Case report | Surgical Management of Osteoarthritis of the Knee CPG | Meniscal bearing fracture is a rare complication of phase III Oxford unicompartmental knee replacement (UKR). We report a case of a meniscal bearing fracture that occurred 7. years after phase III Oxford medial UKR. The meniscal bearing showed uneven delamination of the polyethylene in the thinnest articular surface an... |
0 | Musculoskeletal complications associated with lysosomal storage disorders: Gaucher disease and Hurler-Scheie syndrome (mucopolysaccharidosis type I) | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | Purpose of review: Enzyme therapy for lysosomal storage disorders directed at correcting the underlying cause of disease represents the most significant recent advance in patient management. This review focuses on two disease groups: glycosphingolipidoses and mucopolysaccharidoses. Specifically, Gaucher disease and Hur... |
0 | Using the contralateral reverse less invasive plating system for subtrochanteric femur fractures in elderly patients | Hip Fx Time to Surgery | OBJECTIVE: In this retrospective study, we evaluated the efficacy of the reverse less invasive plating system (LISS) in the management of subtrochanteric fractures (STF) in elderly patients that are expected to be difficult to nail. SUBJECTS AND METHODS: Fifty-five patients with STF were treated from April 2005 to Dece... |
0 | Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease: effects on bone | AAHKS (2) Corticosteroids | UNLABELLED: Context Patients with primary adrenal insufficiency (Addison's disease) receive more glucococorticoids than the normal endogenous production, raising concern about adverse effects on bone.
OBJECTIVE: To determine i) the effects of glucocorticoid replacement therapy on bone, and ii) the impact of glucocortic... |
0 | Hospitalization costs of total knee arthroplasty with a continuous femoral nerve block provided only in the hospital versus on an ambulatory basis: a retrospective, case-control, cost-minimization analysis | AAHKS (8) Anesthetic Infiltration | BACKGROUND AND OBJECTIVES: After total knee arthroplasty (TKA), hospitalization may be shortened by allowing patients to return home with a continuous femoral nerve block (CFNB). This study quantified the hospitalization costs for 10 TKA patients receiving ambulatory CFNB versus a matched cohort of 10 patients who rece... |
0 | Comparison between single stage and two stage bilateral total hip replacement- our results and review of literature | Developmental Dysplasia of the Hip 2020 Review | Bilateral total hip replacement (THR) is a common procedure nowdays. Staging of surgery is still a -matter of debate. We performed a study to compare single stage and two stage bilateral THR and discuss the peri-operative and post-operative advantages and complications. This was a retrospective study. 48 patients under... |
0 | Injured or arthritic knees: Evaluating patellofemoral and tibiofemoral articulation | AMP (Acute Meniscal Pathology) | Palpate the entire retinaculum, retropatellar surface, and trochlear grooves when examining the patellofemoral articulation in a patient with an injured or arthritic knee. Various manipulations of the patella reveal retinacular tightness, instability, or symptomatic chondromalacia. A tight lateral retinaculum or an inc... |
0 | Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis | OAK 3 - Non-arthroplasty tx of OAK | Objective: Conventional treatment of osteoarthritis (OA) with nonâ?steroidal antiâ?inflammatory drugs is associated with serious gastrointestinal side effects and in view of the recent withdrawal of some cycloâ?oxygenaseâ?2 inhibitors, identifying safer alternative treatment options is needed. The objective of this... |
0 | Subacute nerve compressions after trauma and surgery of the hand | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | BACKGROUND: It is accepted that major injuries of the upper limb may require not only fasciotomies but also nerve decompressions. That nerve compression(s) may occur after less dramatic injuries and "routine" surgery distal to the elbow is less well documented in the literature but well known to experienced clinicians.... |
0 | Central field perimetry of discriminated targets: I. Results for normal individuals using high-contrast targets | Upper Eyelid and Brow Surgery | PURPOSE: A new perimetry method is described to evaluate central vision under multiple hue, illumination, and contrast conditions; results are described for normal individuals using high-contrast targets. METHODS: For 70 normal eyes of individuals with varying age, the ETDRS chart acuity was determined as well as discr... |
0 | External fixation in the treatment of supracondylar femoral fractures | DoD SSI (Surgical Site Infections) | Comminuted fractures of the distal femur are difficult to treat because of the problems arising from anatomical reconstruction of the articular surfaces and good stabilization of the fragments must be achieved. Such fractures can be open, or associated to soft tissue damage or major trauma to other parts of the body. C... |
1 | Lipoabdominoplasty and the leptin hormone | Panniculectomy & Abdominoplasty CPG | BACKGROUND: Obesity contributes to a chronic disease with lethal complications. Leptin as an adiponectin interacts with fat metabolism. Surgical extra fat resection is an interventional approach to control obesity. We aimed to evaluate how body contouring surgery would influence on leptin plasma level. METHODS: Females... |
0 | Ergonomics and the effects of vibration in hand-intensive work | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | Along with ergonomic factors, such as forceful and repeated exertion and certain postures, vibration has been cited as a factor of chronic nerve and tendon disorders such as carpal tunnel syndrome and tendinitis. The arguments for the contribution of vibration come from epidemiologic studies, clinical case analyses, an... |
0 | Locked intramedullary nailing versus dynamic compression plating for humeral shaft fractures | MSTS 2022 - Metastatic Disease of the Humerus | PURPOSE . To compare functional outcomes, union and complication rates in patients treated with locked intramedullary nailing or dynamic compression plating for humeral shaft fractures. METHODS. 32 men and 2 women with humeral shaft fractures were randomised to undergo locked antegrade intramedullary nailing (IMN, n=16... |
1 | Ultrasonography in developmental hip dysplasia | Developmental Dysplasia of the Hip CPG | With the evolving use of ultrasonography, there has been an increasing emphasis on the technically oriented diagnosis of developmental hip dysplasia. Graf's alpha and beta angles and Harcke's bony rim percentage are two of the more common criteria, but their repeatability and reliability have not been well documented. ... |
1 | Intramedullary fixation of tibial shaft fractures: A comparison of the unlocked and interlocked nail | DoD SSI (Surgical Site Infections) | The study is a prospective evaluation and comparison. Eighty-two patients with tibial shaft fractures were treated with intramedullary fixation by either an unlocked nail (ULN) or an interlocked nail (ILN). All patients were followed up for 12 months with a functional score evaluation. The patients were divided into tw... |
0 | Intra- and extra-capsular hip fractures in the elderly: Two different pathologies? | Hip Fx in the Elderly 2019 | OBJECTIVES: To compare intracapsular (IC) and extracapsular (EC) hip fractures (HIF) in elderly patients in order to determine if they are different pathologies.
SUBJECTS AND METHODS: Longitudinal, observational, descriptive, analytical prospective design, using a non-probabilistic sample from a full sample collection ... |
0 | Comparison of Two Multimodal Analgesia Regimens in Total Knee Arthroplasty | AAHKS (4) Acetaminophen | The improvement of postoperative analgesia is an important issue in orthopedic surgery, especially after total knee arthroplasty. The early postoperative mobilization of these patients is crucial to ensure a favorable functional evolution, and this goal can't be accomplished without effective analgesia. Opioids offer a... |
0 | Comminuted displaced Colles' fractures. Treatment with intramedullary methylmethacrylate stabilisation | Distal Radius Fractures | Four women aged 87, 77, 74 and 69 years with severely comminuted, displaced and intraarticular Colles' fractures of the dominant hand, where conservative treatment had failed, were treated by use of intramedullary methylmethacrylate stabilisation in order to retain optimal anatomical position of the fracture. The patie... |
0 | Three-dimensional topographical variation of femoral cartilage T2 in healthy volunteer knees | AMP (Acute Meniscal Pathology) | OBJECTIVE: Quantitative knee cartilage T2 assessment on limited two-dimensional midsagittal or midcoronal planes may be insufficient to assess variations in normal cartilage composition. The purpose of this work was to reveal characteristic 3D distribution of T2 values in femoral cartilage in healthy volunteer knees.
M... |
0 | Joint motion of bipolar hemiarthroplasty in routine hip functional movements: a dynamic motion study | Hip Fx in the Elderly 2019 | Background: Many motion studies have shown that the inner bearing of bipolar prostheses moves less than expected under non-weight-bearing and static weight-bearing positions, which are not routine functional movements performed postoperatively. The aim of this study was to investigate the behaviours of bipolar prosthes... |
0 | Time to Explore Preventive and Novel Therapies for Bronchiolitis Obliterans Syndrome after Allogeneic Hematopoietic Stem Cell Transplantation | Reconstruction After Skin Cancer | Although allogeneic hematopoietic stem cell transplant (allo-HSCT) is performed to treat otherwise incurable and fatal diseases, transplantation itself can lead to life-threatening complications due to organ damage. Pulmonary complications remain a significant barrier to the success of allo-HSCT. Lung injury, a frequen... |
0 | Rehabilitation Strategies for Patients with Femoral Neck Fractures in Sarcopenia: A Narrative Review | Hip Fx in the Elderly 2019 | Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. It has been identified as one of the most common comorbidities associated with femoral neck fracture (FNF). The aim of this review was to evaluate the impact of physical therapy on FNF patients' f... |
0 | Twelve years of experience of acquired hemophilia A: Trials and tribulations in South Australia | DOD - Acute Comp Syndrome CPG | Acquired hemophilia A (AH) is a rare and serious acquired bleeding disorder where prompt and correct diagnosis is crucial, and immune suppression is often required for factor VIII (FVIII) autoantibody eradication. The acquired FVIII deficiency usually manifests as bruises and bleeding, and treatment such as FVIII has l... |
0 | Osteoblastic osteosarcoma: cytomorphologic characteristics and differential diagnosis on fine-needle aspiration | MSTS 2022 - Metastatic Disease of the Humerus | OBJECTIVES: To review cytomorphologic characteristics of osteoblastic osteosarcoma (OOS), a variant of osteosarcoma, on fine-needle aspiration (FNA) and correlate them with histopathologic features and clinical outcomes.
STUDY DESIGN: A retrospective review of the cytopathology archives of The Johns Hopkins Hospital re... |
1 | Clinical Outcomes for Breast Cancer Patients Undergoing Mastectomy and Reconstruction with Use of DermACELL, a Sterile, Room Temperature Acellular Dermal Matrix | Acellular Dermal Matrix | Background. Decellularized human skin has been used in a variety of medical applications, primarily involving soft tissue reconstruction, wound healing, and tendon augmentation. Theoretically, decellularization removes potentially immunogenic material and provides a clean scaffold for cellular and vascular in growth. T... |
0 | Imaging the vascularisation of the femoral head by CT angiography | Management of Hip Fractures in the Elderly | The femoral head receives its blood supply primarily from the medial femoral circumflex artery, with its deep branch being the most important. In a previous study, we performed classical anatomical dissections of 16 hips. We have extended our investigation with a radiological study, in which we aimed to visualise the a... |
0 | What are the clinical implications of knee crepitus to individuals with knee osteoarthritis? An observational study with data from the Osteoarthritis Initiative | OAK 3 - Non-arthroplasty tx of OAK | BACKGROUND: Crepitus is a common clinical feature of knee osteoarthritis. However, the importance of crepitus in the overall clinical presentation of individuals with knee osteoarthritis is unknown. OBJECTIVE(S): (A) To compare function, pain and quality of life between individuals with knee osteoarthritis with and wit... |
0 | Burden of fractures in France: incidence and severity by age, gender, and site in 2016 | Hip Fx in the Elderly 2019 | PURPOSE: Fractures are common events, but the exact incidence and severity of fractures have not been clearly determined for most anatomical sites. We estimated the incidence and severity of fractures in France regardless of the anatomical site.
METHODS: Observational cross-sectional study in France in 2016 based on th... |
1 | Acute compartment syndrome. Effect of dermotomy on fascial decompression in the leg | DOD - Acute Comp Syndrome CPG | Prompt surgical decompression is the only means of preventing the late sequelae of ischaemic contracture in post-traumatic compartment syndromes. However, controversy exists regarding the length of dermotomy required for adequate decompression in the lower extremity. This study investigated the skin envelope as a poten... |
0 | Lateral reinforcement in anterior cruciate ligament reconstruction | OAK 3 - Non-arthroplasty tx of OAK | Lateral extra-articular procedures were popular in the treatment of anterior cruciate ligament injury in the nineteen seventies and eighties, but fell from favor due to poor results, concerns regarding biomechanics, and concurrent advances in intra-articular reconstruction. Persistent problems with rotational control i... |
0 | Antimicrobial susceptibility of coagulase-negative staphylococci on tissue allografts and isolates from orthopedic patients | Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures | Allograft infection occurs at a rate not different from that of similar procedures with large allografts or sterilized prosthetic devices and is usually caused by coagulase-negative staphylococci (CNS). CNS are feared for their limited antimicrobial susceptibility. We aimed at investigating this risk. CNS were isolated... |
0 | Transthyretin Tyr77 familial amyloid polyneuropathy: a clinicopathological study of a large kindred | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | More than 40 point mutations (producing different clinical manifestations) have been described in diverse points of the plasma protein transthyretin (TTR). The Met30 is considered the most common mutation, the Tyr77 mutation being the second most prevalent. However, data from patients with this late mutation are scarce... |
0 | A microcomputer based audit of fracture of the proximal femur in the elderly | Management of Hip Fractures in the Elderly | A microcomputer was used for patient record management and statistical analysis to study prospectively an elderly female population with femoral neck fracture. Of 150 patients studied, 58% presented with a cervical fracture and 42% with a trochanteric fracture. The patients with trochanteric fracture were significantly... |
0 | The Role of Sonic Hedgehog Signaling in Osteoclastogenesis and Jaw Bone Destruction | MSTS 2018 - Femur Mets and MM | Sonic hedgehog (SHH) and its signaling have been identified in several human cancers, and increased levels of its expression appear to correlate with disease progression and metastasis. However, the role of SHH in bone destruction associated with oral squamous cell carcinomas is still unclear. In this study we analyzed... |
0 | The localization of human breast carcinomas by radiolabelled monoclonal antibodies | MSTS 2018 - Femur Mets and MM | Immune-deprived mice bearing HX99 human breast carcinoma xenografts were injected with a radiolabelled monoclonal antibody, LICR-LON-M8 (M8), to investigate the dependence of tumour localization on (i) tumour site and (ii) antibody radiolabel. No significant difference was found in the degree of localization of radio-i... |
0 | Venomous snakebites in children in southern Croatia | DOD - Acute Comp Syndrome CPG | This retrospective study represents observation of 160 children and adolescents aged up to 18 years that experienced venomous snakebites in southern Croatia and were treated in the Clinical Department of Infectious Diseases in the University Hospital Centre Split from 1979 to 2013. The main purpose of this research was... |
0 | Involvement of different risk factors in clinically severe large joint osteoarthritis according to the presence of hand interphalangeal nodes | Surgical Management of Osteoarthritis of the Knee CPG | OBJECTIVE: To quantify the differences in risk factors influencing total hip replacement (THR) and total knee replacement (TKR) based on the presence versus absence of multiple interphalangeal nodes in 2 or more rays of the fingers of each hand in patients with large joint osteoarthritis (OA). METHODS: A group of 3,800... |
0 | Analysis of meniscal degeneration and meniscal gene expression | DoD LSA (Limb Salvage vs Amputation) | Background. Menisci play a vital role in load transmission, shock absorption and joint stability. There is increasing evidence suggesting that OA menisci may not merely be bystanders in the disease process of OA. This study sought: 1) to determine the prevalence of meniscal degeneration in OA patients, and 2) to examin... |
1 | Intraneural median nerve pressure in carpal tunnel syndrome | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | In order to determine whether endoscopic carpal tunnel release decompresses the median nerve, we measured the intraneural median nerve pressure pre- and postoperatively in 55 hands. The median nerve pressure was significantly reduced postoperatively |
0 | Preventing delirium in older adults with recent hip fracture through multidisciplinary geriatric consultation | Management of Hip Fractures in the Elderly | OBJECTIVES: To evaluate the effect of inpatient geriatric consultation teams (IGCTs), which have been introduced to improve the quality of care of older persons hospitalized on nongeriatric wards, on delirium and overall cognitive functioning in older adults with hip fracture. DESIGN: Controlled trial. SETTING: Two tra... |
0 | Increased incident hip fractures in postmenopausal women with moderate to severe pelvic organ prolapse | Management of Hip Fractures in the Elderly | OBJECTIVE: The aim of this study was to examine the association between fracture and pelvic organ prolapse (POP) in postmenopausal women enrolled in the Women's Health Initiative Estrogen Plus Progestin trial. METHODS: POP was assessed as cystocele, rectocele, or uterine prolapse and was graded as either "absent to mil... |
1 | Subcutaneous Implant-based Breast Reconstruction with Acellular Dermal Matrix/Mesh: A Systematic Review | Acellular Dermal Matrix | BACKGROUND: The availability of acellular dermal matrix (ADM) and synthetic mesh products has prompted plastic surgeons to revisit subcutaneous implant-based breast reconstruction. The literature is limited, however, with regards to evidence on patient selection, techniques, and outcomes. METHODS: A systematic review o... |
0 | The Minimal Clinically Important Difference and Substantial Clinical Benefit in the Patient-Reported Outcome Measures of Patients Undergoing Osteochondral Allograft Transplantation in the Knee | AMP (Acute Meniscal Pathology) | Objective: Little is known regarding the minimal clinically important difference (MCID) and substantial clinical benefit (SCB) with regard to the Knee injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form, Lysholm score, and Short Form 12 (SF-1... |
0 | Pathologic femoral fracture after periosteal excision and radiation for the treatment of soft tissue sarcoma | MSTS 2022 - Metastatic Disease of the Humerus | BACKGROUND: Surgical resection and adjuvant radiation therapy are standard therapy for soft tissue sarcomas. When the tumor approximates bone, periosteal excision may be necessary. It was hypothesized that periosteal stripping and radiation therapy would increase the rate of pathologic fracture.
METHODS: The soft tissu... |
0 | Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials | OAK 3 - Non-arthroplasty tx of OAK | OBJECTIVE: To investigate the efficacy and safety of a standardized willow bark extract in patients with osteoarthritis (OA) and rheumatoid arthritis (RA). METHODS: We studied 127 outpatients with hip or knee OA and a WOMAC pain score of at least 30 mm and 26 outpatients with active RA in 2 randomized, controlled, doub... |
0 | Radial nerve paralysis associated with fractures of the humerus. A review of 62 cases | Distal Radius Fractures | Sixty-two patients with radial nerve paralysis associated with fractures of the humerus were reviewed. Seventy-three per cent of the patients had primary radial nerve paralysis and 27% had secondary paralysis. Conservative management has led to excellent nerve recovery in all groups of patients. Overall, 95% of the pat... |
0 | The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa | Upper Eyelid and Brow Surgery | Retinitis pigmentosa is a clinical and genetic group of inherited retinal disorders characterized by alterations of photoreceptors and retinal pigment epithelium leading to a progressive concentric visual field restriction, which may bring about severe central vision impairment. Haemodynamic studies in patients with re... |
0 | Clinical feasibility of a novel biphasic osteochondral composite for matrix-associated autologous chondrocyte implantation | Osteochondritis Dissecans 2020 Review | OBJECTIVE: Matrix-associated autologous chondrocyte implantation has been used to treat cartilage defects. We developed a biphasic cylindrical osteochondral composite construct for such use, and conducted this study to determine its feasibility for treating osteochondral lesions in human knees. METHOD: Ten patients wit... |
0 | Exercise for depression | SR for PM on OA of All Extremities | Background: Depression is a common and important cause of morbidity and mortality worldwide. Depression is commonly treated with antidepressants and/or psychological therapy, but some people may prefer alternative approaches such as exercise. There are a number of theoretical reasons why exercise may improve depression... |
0 | Factors influencing infection rate in open fracture wounds | DoD SSI (Surgical Site Infections) | Seventy-seven infections in 1104 open fracture wounds were evaluated to identify those factors that predisposed to infection. Factors could be placed into three categories: (1) increased risk, (2) no effect, and (3) inconclusive. The single most important factor in reducing the infection rate was the early administrati... |
1 | Cemented hemiarthroplasty or hip replacement for intracapsular neck of femur fracture? A comparison of 7732 matched patients using national data | Hip Fx in the Elderly 2019 | Background The treatment of choice for intracapsular neck of femur (NOF) fractures in younger, more active patients remains unknown. Some surgeons advocate total hip replacement (THR). Aim This study aimed to compare complications following THR and hemiarthroplasty using the Hospital Episode Statistics (HES) database i... |
1 | Cephradine and flucloxacillin in the prophylaxis of infection in patients with open fractures | DoD SSI (Surgical Site Infections) | A comparison of prophylactic antibiotic cover of cephradine or flucloxacillin in sixty patients with open fractures is reported. There were more infections in the flucloxacillin than in the cephradine group and gastrointestinal side-effects were more common. The overall incidence of infection in the whole group, two ou... |
0 | Vitamin D receptor gene polymorphism in men and its effect on bone density and calcium absorption | Management of Hip Fractures in the Elderly | OBJECTIVE: Previous studies have suggested that polymorphism of the alleles of the vitamin D receptor (VDR) gene may account for the major part of the heritable component of bone density in women, possibly mediated in part by impaired calcium absorption from the bowel. In view of the increasing importance of osteoporos... |
0 | Differential isolation of normal luminal mammary epithelial cells and breast cancer cells from primary and metastatic sites using selective media | Reduction Mammoplasty for Female Breast Hypertrophy | The present studies were aimed at determining if the use of a cell culture medium that supports proliferation of human mammary epithelial cells of the luminal lineage would allow routine isolation of breast cancer cells from primary and metastatic tumor specimens. Results obtained with mammary epithelial cells derived ... |
0 | Evaluation of Motor Sparing Knee Block to Infiltration Analgesia for Pain Following Knee Arthroplasty | AAHKS (9/10) Regional Nerve Blocks | This prospective randomised double blind study will be conducted on 90 patients undergoing primary total knee arthroplasties of American society of anesthesiologists physical status (ASA) 1â?3 class. Patients will be educated regarding verbal rating score (0=no pain; 10= worst pain ever) and postoperative rehabilitati... |
0 | Time trends in incidence rates of first hip fracture in the Uppsala Health Care Region, Sweden, 1965-1983 | Management of Hip Fractures in the Elderly | Time trends from 1965 through 1983 for age-specific and age-standardized rates of first hospital admission for a proximal femur fracture were studied in the Uppsala Health Care Region, Sweden, using a centralized register for inpatient care. During the 19-year study period, 29,277 hospital admissions for a first hip fr... |
0 | Local infusion analgesia using intra-articular double lumen catheter after total knee arthroplasty: a double blinded randomized control study | OAK 3 - Non-arthroplasty tx of OAK | PURPOSE: Although intra-operative local infiltration analgesia has gained increasing popularity in joint replacement surgery, it is not clear whether postoperative local infusion analgesia using an indwelling catheter provides clinically important additional effects. We, therefore, conducted a randomized controlled tri... |
0 | Accumulation and washout of 99mtc-sestamibi in osteoarthritic subchondral bone may indicate increased osteoclastic activity accompanying microfractures: A case study | PJI DX Updated Search | We show for the first time that imaging of osteoarthritic subchondral bone with 99mTc-sestamibi (MIBI) may be a valuable diagnostic tool to assess the severity of subchondral sclerosis. This is a report on a patient who had osteoarthritis of both knees and where MIBI was accumulated in the lesion sites. Due to the accu... |
1 | Valgus bracing for knee osteoarthritis: a meta-analysis of randomized trials | OAK 3 - Non-arthroplasty tx of OAK | OBJECTIVE: To evaluate the effects of valgus knee bracing on pain and function, and compliance and complications, in patients with medial knee osteoarthritis (OA).
METHODS: A meta-analysis of randomized controlled trials that compared changes in patient-reported pain and/or function in patients with medial knee OA was ... |
0 | Management of Arterial Injury in Children with Supracondylar Fracture of the Humerus and a Pulseless Hand | Pediatric Supracondylar Humerus Fracture 2020 Review | Objective: To share our experience regarding the management of arterial injuries in children with pulseless hand secondary to supracondylar fracture of the humerus (SFH). Patients and Methods: All consecutive children with pulseless hands after SFH who were being treated in the vascular surgery units of the Combined Mi... |
0 | Genome-wide association study identifies the GLDC/IL33 locus associated with survival of osteosarcoma patients | MSTS 2022 - Metastatic Disease of the Humerus | Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall survi... |
0 | Determinants of poor dental care in patients with schizophrenia: A historical, prospective database study | Prevention of Orthopaedic Implant Infection in Patients Undergoing Dental Procedures | Background: Oral health status is poor and a disregarded health issue among patients with schizophrenia that is associated with the risk for additional social stigmatization and potentially fatal infections. Method: A historical, prospective database study of dental visits, utilizing the Danish National Patient Registr... |
0 | Autologous bone-marrow mesenchymal cell induced chondrogenesis (MCIC) | Osteochondritis Dissecans 2020 Review | Degenerative and traumatic articular cartilage defects are common, difficult to treat, and progressive lesions that cause significant morbidity in the general population. There have been multiple approaches to treat such lesions, including arthroscopic debridement, microfracture, multiple drilling, osteochondral transp... |
0 | Central mechanisms of experimental and chronic neuropathic pain: findings from functional imaging studies | Diagnosis and Treatment of Carpal Tunnel Syndrome CPG | Over the last few years remarkable efforts have been made using functional imaging studies to unravel brain processing of pain and decipher underlying neuronal mechanisms. Cerebral processing in experimental pain models, especially those provoking hyperalgesia, and its pharmacological modulation will form the first par... |
0 | Aprotinin decreases exposure to allogeneic blood during primary unilateral total hip replacement | Management of Hip Fractures in the Elderly | BACKGROUND: Aprotinin, a hemostatic agent, regulates fibrinolysis, modulates the intrinsic coagulation pathway, stabilizes platelet function, and exhibits anti-inflammatory properties through inhibition of serine proteases, such as trypsin, plasmin, and kallikrein. Aprotinin has been used successfully for many years in... |
0 | Hip Fracture Volume Does Not Change at a New York City Level 1 Trauma Center During a Period of Social Distancing | Pediatric Supracondylar Humerus Fracture 2020 Review | PURPOSE: To characterize the volume and variation in orthopedic consults and surgeries that took place during a period of social distancing and pandemic. METHODS: All orthopedic consults and surgeries at an urban level 1 trauma center from 3/22/20-4/30/2020 were retrospectively reviewed (the social distancing period). ... |
0 | Synergistic effect of statins and postmenopausal hormone therapy in the prevention of skeletal fractures in elderly women | Management of Hip Fractures in the Elderly | STUDY OBJECTIVE: To examine the role of concurrent 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin) use and postmenopausal hormone therapy on osteoporosis-related fractures. DESIGN: Case-control study. Data Source. Large integrated health plan in New Mexico. Patients. Case patients were 1001 women wit... |
0 | Bisphosphonates enhance antitumor effect of EGFR-TKIs in patients with advanced EGFR mutant NSCLC and bone metastases | MSTS 2018 - Femur Mets and MM | Whether bisphosphonates could enhance the effect of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in non-small-cell lung cancer (NSCLC) patients with EGFR mutation and bone metastases (BM) remains unknown. EGFR mutation status were collected from 1560 patients with NSCLC and BM. 356 NSCLC pa... |
0 | Etidronate does not suppress periprosthetic bone loss following cemented hip arthroplasty | Management of Hip Fractures in the Elderly | Periprosthetic bone loss after arthroplasty may threaten prosthesis survival. The current study investigated the effect of etidronate therapy on periprosthetic, contralateral hip, and spine bone mineral density (BMD) in a one-year, prospective, randomized, double-blind study on 46 patients after cemented hip arthroplas... |
1 | Meniscal repair in the young athlete | Anterior Cruciate Ligament Injuries CPG | Twenty-nine meniscal repairs in 26 patients 17 years of age or younger were performed using arthroscopic techniques. Clinical follow-up examinations were performed and the SF-36 Health Status Survey and International Knee Documentation Committee evaluation form were administered. A Lysholm score was determined for each... |
0 | Acute injuries of the distal radioulnar joint | Distal Radius Fractures | Acute injuries of the distal radioulnar joint are common. They often are not treated aggressively owing to a failure to diagnose or the misconception that there is little functional impairment if left untreated. Early aggressive treatment with restoration of anatomic alignment and stability will yield optimum results. ... |
1 | Sleep disturbance and upper-extremity disability | DoD PRF (Psychosocial RF) | Background: Although upper-extremity disability correlates with psychosocial aspects of illness the association with sleep disturbance in upper extremity disability is less certain. To evaluate whether sleep disturbance is associated with upper-extremity disability among patients with upper extremity illness, accountin... |
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