origin_title stringlengths 27 249 | origin_abstract stringlengths 249 3.46k | chemical_entitiesList listlengths 1 42 | disease_entitiesList listlengths 1 33 | label listlengths 1 28 | head_chemical_entName listlengths 1 28 | tail_disease_entName listlengths 1 28 | tail_entity_dict listlengths 1 28 | head_entity_dict listlengths 1 28 | intra-sentence listlengths 1 28 |
|---|---|---|---|---|---|---|---|---|---|
Naloxone reverses the antihypertensive effect of clonidine. | In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone d... | [
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"offsets": [
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0,
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"text": [
"Naloxone"
],
"type": "Chemical"
},
{
"id": "4",
"normalized": [
{
"db_id": "D003000",
... | [
{
"id": "5",
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{
"db_id": "D006973",
"db_name": "MESH"
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93,
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"text": [
"hypertensive"
],
"type": "Disease"
},
{
"id": "8",
"normalized": [
{
"db_id": "D007... | [
"Yes",
"No"
] | [
"alpha-methyldopa",
"clonidine"
] | [
"hypotensive",
"hypotensive"
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{
"id": "8",
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{
"db_id": "D007022",
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274,
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"hypotensive"
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{
"id": "8",
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{
"db_id": "D007... | [
{
"id": "9",
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{
"db_id": "D008750",
"db_name": "MESH"
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306,
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"text": [
"alpha-methyldopa"
],
"type": "Chemical"
},
{
"id": "4",
"normalized": [
{
"db_id":... | [
true,
false
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Lidocaine-induced cardiac asystole. | Intravenous administration of a single 50-mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to the development of bradyarrhythmias; and, th... | [
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"db_id": "D008012",
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"offsets": [
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0,
9
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"text": [
"Lidocaine"
],
"type": "Chemical"
},
{
"id": "30",
"normalized": [
{
"db_id": "D008012... | [
{
"id": "29",
"normalized": [
{
"db_id": "D006323",
"db_name": "MESH"
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"offsets": [
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18,
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"text": [
"cardiac asystole"
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"type": "Disease"
},
{
"id": "31",
"normalized": [
{
"db_id": ... | [
"Yes",
"No"
] | [
"Lidocaine",
"Lidocaine"
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"cardiac asystole",
"depression"
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{
"id": "29",
"normalized": [
{
"db_id": "D006323",
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18,
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"text": [
"cardiac asystole"
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"type": "Disease"
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{
"id": "31",
"normalized": [
{
"db_id": ... | [
{
"id": "28",
"normalized": [
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"db_id": "D008012",
"db_name": "MESH"
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0,
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"text": [
"Lidocaine"
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"type": "Chemical"
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{
"id": "28",
"normalized": [
{
"db_id": "D008012... | [
true,
true
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Suxamethonium infusion rate and observed fasciculations. A dose-response study. | Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 mg was exceeded. Six additional patients received a 30-mg i.v. bolus dose. Fasci... | [
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0,
13
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"text": [
"Suxamethonium"
],
"type": "Chemical"
},
{
"id": "42",
"normalized": [
{
"db_id": "D0... | [
{
"id": "41",
"normalized": [
{
"db_id": "D005207",
"db_name": "MESH"
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"offsets": [
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41,
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"text": [
"fasciculations"
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"type": "Disease"
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{
"id": "44",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"Suxamethonium",
"Suxamethonium"
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"fasciculations",
"tetanic"
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{
"id": "41",
"normalized": [
{
"db_id": "D005207",
"db_name": "MESH"
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"offsets": [
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41,
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"text": [
"fasciculations"
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"type": "Disease"
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{
"id": "44",
"normalized": [
{
"db_id": "D... | [
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"id": "40",
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"offsets": [
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0,
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"type": "Chemical"
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{
"id": "40",
"normalized": [
{
"db_id": "D0... | [
true,
true
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Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine). | Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neuromuscular block. However, ... | [
{
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{
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"offsets": [
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0,
25
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"text": [
"Galanthamine hydrobromide"
],
"type": "Chemical"
},
{
"id": "86",
"normalized": [
{
... | [
{
"id": "91",
"normalized": [
{
"db_id": "D062787",
"db_name": "MESH"
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"offsets": [
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315,
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],
"text": [
"overdosage"
],
"type": "Disease"
}
] | [
"Yes",
"No"
] | [
"scopolamine",
"physostigmine"
] | [
"overdosage",
"overdosage"
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{
"id": "91",
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"db_id": "D062787",
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"offsets": [
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315,
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"text": [
"overdosage"
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{
"id": "91",
"normalized": [
{
"db_id": "D06... | [
{
"id": "86",
"normalized": [
{
"db_id": "D012601",
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"offsets": [
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111,
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"text": [
"scopolamine"
],
"type": "Chemical"
},
{
"id": "92",
"normalized": [
{
"db_id": "D... | [
true,
false
] |
Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats. | Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a lithium-containing diet (50 mmol/kg) for 8 weeks and then r... | [
{
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"normalized": [
{
"db_id": "D008094",
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],
"offsets": [
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54,
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],
"text": [
"lithium"
],
"type": "Chemical"
},
{
"id": "104",
"normalized": [
{
"db_id": "D0080... | [
{
"id": "103",
"normalized": [
{
"db_id": "D007676",
"db_name": "MESH"
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],
"offsets": [
[
70,
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"text": [
"chronic renal failure"
],
"type": "Disease"
},
{
"id": "105",
"normalized": [
{
"d... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"lithium",
"lithium",
"lithium",
"lithium",
"creatinine",
"creatinine"
] | [
"hypertension",
"proteinuria",
"chronic renal failure",
"glomerulosclerosis",
"renal failure",
"nephropathy"
] | [
{
"id": "117",
"normalized": [
{
"db_id": "D006973",
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"offsets": [
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1000,
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"text": [
"hypertension"
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"type": "Disease"
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{
"id": "116",
"normalized": [
{
"db_id"... | [
{
"id": "102",
"normalized": [
{
"db_id": "D008094",
"db_name": "MESH"
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"offsets": [
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54,
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"text": [
"lithium"
],
"type": "Chemical"
},
{
"id": "102",
"normalized": [
{
"db_id": "D0080... | [
true,
true,
true,
true,
true,
false
] |
Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. | Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy... | [
{
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"db_id": "D005672",
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"offsets": [
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34,
46
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"text": [
"fusidic acid"
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"type": "Chemical"
},
{
"id": "217",
"normalized": [
{
"db_id": "... | [
{
"id": "215",
"normalized": [
{
"db_id": "D003424",
"db_name": "MESH"
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],
"offsets": [
[
13,
28
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],
"text": [
"Crohn's disease"
],
"type": "Disease"
},
{
"id": "219",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
] | [
"fusidic acid",
"fusidic acid"
] | [
"nausea",
"inflammatory bowel disease"
] | [
{
"id": "224",
"normalized": [
{
"db_id": "D009325",
"db_name": "MESH"
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],
"offsets": [
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910,
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"text": [
"nausea"
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"type": "Disease"
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{
"id": "228",
"normalized": [
{
"db_id": "D0152... | [
{
"id": "216",
"normalized": [
{
"db_id": "D005672",
"db_name": "MESH"
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34,
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"fusidic acid"
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"type": "Chemical"
},
{
"id": "216",
"normalized": [
{
"db_id": "... | [
false,
true
] |
Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers. | The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block. | [
{
"id": "239",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
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],
"offsets": [
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83,
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],
"text": [
"cocaine"
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"type": "Chemical"
},
{
"id": "240",
"normalized": [
{
"db_id": "D0030... | [
{
"id": "238",
"normalized": [
{
"db_id": "D009202",
"db_name": "MESH"
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],
"offsets": [
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33,
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"text": [
"myocardial injury"
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{
"id": "241",
"normalized": [
{
"db_id... | [
"Yes",
"Yes",
"No",
"No"
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"cocaine",
"cocaine"
] | [
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"ischemia",
"myocardial injury"
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{
"id": "244",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
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],
"offsets": [
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334,
355
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],
"text": [
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],
"type": "Disease"
},
{
"id": "246",
"normalized": [
{
... | [
{
"id": "239",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
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83,
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],
"text": [
"cocaine"
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"type": "Chemical"
},
{
"id": "239",
"normalized": [
{
"db_id": "D0030... | [
true,
true,
true,
true
] |
Sulpiride-induced tardive dystonia. | Sulpiride is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37-year-old man who developed persistent segmental d... | [
{
"id": "256",
"normalized": [
{
"db_id": "D013469",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
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],
"text": [
"Sulpiride"
],
"type": "Chemical"
},
{
"id": "258",
"normalized": [
{
"db_id": "D0134... | [
{
"id": "257",
"normalized": [
{
"db_id": "D004421",
"db_name": "MESH"
}
],
"offsets": [
[
18,
34
]
],
"text": [
"tardive dystonia"
],
"type": "Disease"
},
{
"id": "261",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"Sulpiride",
"Sulpiride"
] | [
"tardive dystonia",
"parkinsonism"
] | [
{
"id": "257",
"normalized": [
{
"db_id": "D004421",
"db_name": "MESH"
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"offsets": [
[
18,
34
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"text": [
"tardive dystonia"
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"type": "Disease"
},
{
"id": "262",
"normalized": [
{
"db_id"... | [
{
"id": "256",
"normalized": [
{
"db_id": "D013469",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
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],
"text": [
"Sulpiride"
],
"type": "Chemical"
},
{
"id": "256",
"normalized": [
{
"db_id": "D0134... | [
true,
true
] |
Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine. | During an 18-month period of study 41 hemodialyzed patients receiving desferrioxamine (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies d... | [
{
"id": "288",
"normalized": [
{
"db_id": "D003676",
"db_name": "MESH"
}
],
"offsets": [
[
64,
79
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],
"text": [
"desferrioxamine"
],
"type": "Chemical"
},
{
"id": "289",
"normalized": [
{
"db_id"... | [
{
"id": "285",
"normalized": [
{
"db_id": "D014786",
"db_name": "MESH"
},
{
"db_id": "D006311",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
]
],
"text": [
"Ocular and auditory toxicity"
],
"type... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No"
] | [
"desferrioxamine",
"desferrioxamine",
"desferrioxamine",
"desferrioxamine",
"desferrioxamine",
"desferrioxamine"
] | [
"pigmentary retinal deposits",
"Ocular and auditory toxicity",
"Ocular",
"neurosensorial hearing loss",
"toxicity",
"hearing loss"
] | [
{
"id": "297",
"normalized": [
{
"db_id": "D012164",
"db_name": "MESH"
}
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"offsets": [
[
604,
631
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],
"text": [
"pigmentary retinal deposits"
],
"type": "Disease"
},
{
"id": "285",
"normalized": [
{
... | [
{
"id": "288",
"normalized": [
{
"db_id": "D003676",
"db_name": "MESH"
}
],
"offsets": [
[
64,
79
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],
"text": [
"desferrioxamine"
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"type": "Chemical"
},
{
"id": "288",
"normalized": [
{
"db_id"... | [
false,
true,
true,
false,
true,
true
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Myasthenia gravis presenting as weakness after magnesium administration. | We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usually well tolerated. The magnesium was stopped and she recovered over a few days. While she was w... | [
{
"id": "361",
"normalized": [
{
"db_id": "D008274",
"db_name": "MESH"
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],
"offsets": [
[
47,
56
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],
"text": [
"magnesium"
],
"type": "Chemical"
},
{
"id": "364",
"normalized": [
{
"db_id": "D00... | [
{
"id": "360",
"normalized": [
{
"db_id": "D009157",
"db_name": "MESH"
}
],
"offsets": [
[
0,
17
]
],
"text": [
"Myasthenia gravis"
],
"type": "Disease"
},
{
"id": "362",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"magnesium",
"acetylcholine"
] | [
"Myasthenia gravis",
"preeclampsia"
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{
"id": "360",
"normalized": [
{
"db_id": "D009157",
"db_name": "MESH"
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],
"offsets": [
[
0,
17
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],
"text": [
"Myasthenia gravis"
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"type": "Disease"
},
{
"id": "365",
"normalized": [
{
"db_id"... | [
{
"id": "361",
"normalized": [
{
"db_id": "D008274",
"db_name": "MESH"
}
],
"offsets": [
[
47,
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],
"text": [
"magnesium"
],
"type": "Chemical"
},
{
"id": "369",
"normalized": [
{
"db_id": "D00... | [
true,
false
] |
Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. | Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administration does not contribute... | [
{
"id": "390",
"normalized": [
{
"db_id": "C004656",
"db_name": "MESH"
}
],
"offsets": [
[
0,
18
]
],
"text": [
"Chloroacetaldehyde"
],
"type": "Chemical"
},
{
"id": "391",
"normalized": [
{
"db_i... | [
{
"id": "396",
"normalized": [
{
"db_id": "D006470",
"db_name": "MESH"
},
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
375,
395
]
],
"text": [
"hemorrhagic cystitis"
],
"type": "D... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"Chloroacetaldehyde",
"Chloroacetaldehyde",
"Chloroacetaldehyde",
"Chloroacetaldehyde",
"ifosfamide",
"mesna"
] | [
"hemorrhagic cystitis",
"cystitis",
"hemorrhagic",
"bladder damage",
"bladder damage",
"hemorrhagic"
] | [
{
"id": "396",
"normalized": [
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"db_id": "D006470",
"db_name": "MESH"
},
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
375,
395
]
],
"text": [
"hemorrhagic cystitis"
],
"type": "D... | [
{
"id": "390",
"normalized": [
{
"db_id": "C004656",
"db_name": "MESH"
}
],
"offsets": [
[
0,
18
]
],
"text": [
"Chloroacetaldehyde"
],
"type": "Chemical"
},
{
"id": "390",
"normalized": [
{
"db_i... | [
true,
true,
true,
false,
false,
false
] |
Source of pain and primitive dysfunction in migraine: an identical site? | Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migrain... | [
{
"id": "433",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
156,
169
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "435",
"normalized": [
{
"db_id"... | [
{
"id": "430",
"normalized": [
{
"db_id": "D010146",
"db_name": "MESH"
}
],
"offsets": [
[
10,
14
]
],
"text": [
"pain"
],
"type": "Disease"
},
{
"id": "431",
"normalized": [
{
"db_id": "D008881",... | [
"Yes",
"No"
] | [
"nitroglycerin",
"nitroglycerin"
] | [
"migraine",
"pain"
] | [
{
"id": "431",
"normalized": [
{
"db_id": "D008881",
"db_name": "MESH"
}
],
"offsets": [
[
44,
52
]
],
"text": [
"migraine"
],
"type": "Disease"
},
{
"id": "430",
"normalized": [
{
"db_id": "D0101... | [
{
"id": "433",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
156,
169
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "433",
"normalized": [
{
"db_id"... | [
true,
true
] |
Clotiazepam-induced acute hepatitis. | We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several benzodiazepines, chemically related to clot... | [
{
"id": "479",
"normalized": [
{
"db_id": "C084599",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Clotiazepam"
],
"type": "Chemical"
},
{
"id": "483",
"normalized": [
{
"db_id": "C0... | [
{
"id": "480",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
}
],
"offsets": [
[
26,
35
]
],
"text": [
"hepatitis"
],
"type": "Disease"
},
{
"id": "481",
"normalized": [
{
"db_id": "D056... | [
"Yes",
"No"
] | [
"Clotiazepam",
"benzodiazepines"
] | [
"hepatitis",
"extensive hepatocellular necrosis"
] | [
{
"id": "480",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
}
],
"offsets": [
[
26,
35
]
],
"text": [
"hepatitis"
],
"type": "Disease"
},
{
"id": "482",
"normalized": [
{
"db_id": "D047... | [
{
"id": "479",
"normalized": [
{
"db_id": "C084599",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Clotiazepam"
],
"type": "Chemical"
},
{
"id": "486",
"normalized": [
{
"db_id": "D0... | [
true,
false
] |
Arterial hypertension as a complication of prolonged ketoconazole treatment. | Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet continuous blood pressure monitoring demonstrated hypertension 31 (patient 1) and... | [
{
"id": "528",
"normalized": [
{
"db_id": "D007654",
"db_name": "MESH"
}
],
"offsets": [
[
53,
65
]
],
"text": [
"ketoconazole"
],
"type": "Chemical"
},
{
"id": "530",
"normalized": [
{
"db_id": "... | [
{
"id": "527",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
9,
21
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "529",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"ketoconazole",
"deoxycorticosterone"
] | [
"hypertension",
"hypertension"
] | [
{
"id": "527",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
9,
21
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "527",
"normalized": [
{
"db_id": "D0... | [
{
"id": "528",
"normalized": [
{
"db_id": "D007654",
"db_name": "MESH"
}
],
"offsets": [
[
53,
65
]
],
"text": [
"ketoconazole"
],
"type": "Chemical"
},
{
"id": "535",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat. | Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (A... | [
{
"id": "561",
"normalized": [
{
"db_id": "D000809",
"db_name": "MESH"
}
],
"offsets": [
[
27,
38
]
],
"text": [
"angiotensin"
],
"type": "Chemical"
},
{
"id": "562",
"normalized": [
{
"db_id": "D... | [
{
"id": "563",
"normalized": [
{
"db_id": "D011665",
"db_name": "MESH"
},
{
"db_id": "D051437",
"db_name": "MESH"
}
],
"offsets": [
[
72,
105
]
],
"text": [
"pulmonary and renal insufficiency"
],
... | [
"Yes",
"No"
] | [
"tranexamic acid",
"prostacyclin"
] | [
"intravascular coagulation",
"pulmonary and renal insufficiency"
] | [
{
"id": "566",
"normalized": [
{
"db_id": "D004211",
"db_name": "MESH"
}
],
"offsets": [
[
113,
138
]
],
"text": [
"intravascular coagulation"
],
"type": "Disease"
},
{
"id": "563",
"normalized": [
{
... | [
{
"id": "568",
"normalized": [
{
"db_id": "D014148",
"db_name": "MESH"
}
],
"offsets": [
[
250,
265
]
],
"text": [
"tranexamic acid"
],
"type": "Chemical"
},
{
"id": "587",
"normalized": [
{
"db_i... | [
true,
false
] |
A randomized comparison of labetalol and nitroprusside for induced hypotension. | In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (5... | [
{
"id": "600",
"normalized": [
{
"db_id": "D007741",
"db_name": "MESH"
}
],
"offsets": [
[
27,
36
]
],
"text": [
"labetalol"
],
"type": "Chemical"
},
{
"id": "601",
"normalized": [
{
"db_id": "D00... | [
{
"id": "602",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
67,
78
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "604",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"nitroprusside",
"nitroprusside",
"labetalol",
"labetalol",
"PO2",
"labetalol"
] | [
"hypotension",
"increase in heart rate and cardiac output",
"hypotension",
"increase in heart rate and cardiac output",
"hypertension",
"hypertension"
] | [
{
"id": "602",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
67,
78
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "608",
"normalized": [
{
"db_id": "D0... | [
{
"id": "601",
"normalized": [
{
"db_id": "D009599",
"db_name": "MESH"
}
],
"offsets": [
[
41,
54
]
],
"text": [
"nitroprusside"
],
"type": "Chemical"
},
{
"id": "601",
"normalized": [
{
"db_id": ... | [
true,
true,
true,
false,
false,
false
] |
Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. | Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat. In the course of developing this m... | [
{
"id": "654",
"normalized": [
{
"db_id": "D002220",
"db_name": "MESH"
}
],
"offsets": [
[
8,
21
]
],
"text": [
"carbamazepine"
],
"type": "Chemical"
},
{
"id": "656",
"normalized": [
{
"db_id": "... | [
{
"id": "655",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
54,
62
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "663",
"normalized": [
{
"db_id": "D0126... | [
"Yes",
"No"
] | [
"hexafluorodiethyl ether",
"folate"
] | [
"seizures",
"weight gain"
] | [
{
"id": "663",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
565,
573
]
],
"text": [
"seizures"
],
"type": "Disease"
},
{
"id": "664",
"normalized": [
{
"db_id": "D01... | [
{
"id": "666",
"normalized": [
{
"db_id": "D005481",
"db_name": "MESH"
}
],
"offsets": [
[
621,
644
]
],
"text": [
"hexafluorodiethyl ether"
],
"type": "Chemical"
},
{
"id": "656",
"normalized": [
{
... | [
true,
false
] |
Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. | In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor. Mean arterial pressure (as a percentage of control +/- SEM) during ... | [
{
"id": "693",
"normalized": [
{
"db_id": "D012964",
"db_name": "MESH"
}
],
"offsets": [
[
132,
138
]
],
"text": [
"sodium"
],
"type": "Chemical"
},
{
"id": "694",
"normalized": [
{
"db_id": "D009... | [
{
"id": "696",
"normalized": [
{
"db_id": "D013610",
"db_name": "MESH"
}
],
"offsets": [
[
588,
599
]
],
"text": [
"tachycardia"
],
"type": "Disease"
},
{
"id": "698",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"nitroglycerin",
"hydralazine",
"epinephrine",
"hydralazine"
] | [
"hypotension",
"hypotension",
"tachycardia",
"tachycardia"
] | [
{
"id": "698",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
734,
745
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "698",
"normalized": [
{
"db_id": "... | [
{
"id": "700",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
772,
785
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "699",
"normalized": [
{
"db_id"... | [
true,
true,
false,
true
] |
Death from chemotherapy in gestational trophoblastic disease. | Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug sche... | [
{
"id": "710",
"normalized": [
{
"db_id": "D005047",
"db_name": "MESH"
}
],
"offsets": [
[
399,
408
]
],
"text": [
"Etoposide"
],
"type": "Chemical"
},
{
"id": "711",
"normalized": [
{
"db_id": "D... | [
{
"id": "707",
"normalized": [
{
"db_id": "D003643",
"db_name": "MESH"
}
],
"offsets": [
[
0,
5
]
],
"text": [
"Death"
],
"type": "Disease"
},
{
"id": "708",
"normalized": [
{
"db_id": "D031901",
... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"Etoposide",
"Methotrexate",
"Cyclophosphamide",
"Methotrexate",
"Cyclophosphamide",
"Cisplatin"
] | [
"pulmonary obstruction",
"pulmonary obstruction",
"pulmonary obstruction",
"Death",
"tumor",
"pulmonary obstruction"
] | [
{
"id": "718",
"normalized": [
{
"db_id": "D011655",
"db_name": "MESH"
}
],
"offsets": [
[
701,
722
]
],
"text": [
"pulmonary obstruction"
],
"type": "Disease"
},
{
"id": "718",
"normalized": [
{
... | [
{
"id": "710",
"normalized": [
{
"db_id": "D005047",
"db_name": "MESH"
}
],
"offsets": [
[
399,
408
]
],
"text": [
"Etoposide"
],
"type": "Chemical"
},
{
"id": "711",
"normalized": [
{
"db_id": "D... | [
false,
false,
false,
false,
false,
false
] |
Sexual dysfunction among patients with arthritis. | The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness Scale ... | [
{
"id": "746",
"normalized": [
{
"db_id": "D008727",
"db_name": "MESH"
}
],
"offsets": [
[
642,
654
]
],
"text": [
"methotrexate"
],
"type": "Chemical"
}
] | [
{
"id": "736",
"normalized": [
{
"db_id": "D012735",
"db_name": "MESH"
}
],
"offsets": [
[
0,
18
]
],
"text": [
"Sexual dysfunction"
],
"type": "Disease"
},
{
"id": "737",
"normalized": [
{
"db_id... | [
"Yes",
"No"
] | [
"methotrexate",
"methotrexate"
] | [
"Impotence",
"Sexual dysfunction"
] | [
{
"id": "745",
"normalized": [
{
"db_id": "D007172",
"db_name": "MESH"
}
],
"offsets": [
[
515,
524
]
],
"text": [
"Impotence"
],
"type": "Disease"
},
{
"id": "736",
"normalized": [
{
"db_id": "D0... | [
{
"id": "746",
"normalized": [
{
"db_id": "D008727",
"db_name": "MESH"
}
],
"offsets": [
[
642,
654
]
],
"text": [
"methotrexate"
],
"type": "Chemical"
},
{
"id": "746",
"normalized": [
{
"db_id":... | [
true,
false
] |
Does paracetamol cause urothelial cancer or renal papillary necrosis? | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | [
{
"id": "756",
"normalized": [
{
"db_id": "D000082",
"db_name": "MESH"
}
],
"offsets": [
[
5,
16
]
],
"text": [
"paracetamol"
],
"type": "Chemical"
},
{
"id": "764",
"normalized": [
{
"db_id": "D0... | [
{
"id": "757",
"normalized": [
{
"db_id": "D014523",
"db_name": "MESH"
}
],
"offsets": [
[
23,
40
]
],
"text": [
"urothelial cancer"
],
"type": "Disease"
},
{
"id": "758",
"normalized": [
{
"db_id... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No"
] | [
"phenacetin",
"phenacetin",
"phenacetin",
"phenacetin",
"phenacetin",
"phenacetin",
"paracetamol",
"phenacetin",
"paracetamol",
"paracetamol"
] | [
"renal papillary necrosis",
"cancer of the renal pelvis, ureter or bladder",
"cancer of the",
"cancer of the renal pelvis and bladder",
"cancer of the renal pelvis",
"urothelial cancer",
"cancer of the",
"cancers",
"urothelial cancer",
"cancer of the renal pelvis and bladder"
] | [
{
"id": "758",
"normalized": [
{
"db_id": "D007681",
"db_name": "MESH"
}
],
"offsets": [
[
44,
68
]
],
"text": [
"renal papillary necrosis"
],
"type": "Disease"
},
{
"id": "760",
"normalized": [
{
... | [
{
"id": "764",
"normalized": [
{
"db_id": "D010615",
"db_name": "MESH"
}
],
"offsets": [
[
205,
215
]
],
"text": [
"phenacetin"
],
"type": "Chemical"
},
{
"id": "764",
"normalized": [
{
"db_id": "... | [
true,
true,
true,
true,
true,
false,
true,
false,
true,
true
] |
Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | [
{
"id": "803",
"normalized": [
{
"db_id": "D003622",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Dapsone"
],
"type": "Chemical"
},
{
"id": "807",
"normalized": [
{
"db_id": "D003622... | [
{
"id": "804",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
30,
46
]
],
"text": [
"hemolytic anemia"
],
"type": "Disease"
},
{
"id": "805",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"Dapsone",
"Dapsone"
] | [
"hemolytic anemia",
"leprosy"
] | [
{
"id": "804",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
30,
46
]
],
"text": [
"hemolytic anemia"
],
"type": "Disease"
},
{
"id": "805",
"normalized": [
{
"db_id"... | [
{
"id": "803",
"normalized": [
{
"db_id": "D003622",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Dapsone"
],
"type": "Chemical"
},
{
"id": "803",
"normalized": [
{
"db_id": "D003622... | [
true,
true
] |
Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | [
{
"id": "843",
"normalized": [
{
"db_id": "D008790",
"db_name": "MESH"
}
],
"offsets": [
[
98,
108
]
],
"text": [
"metoprolol"
],
"type": "Chemical"
},
{
"id": "844",
"normalized": [
{
"db_id": "D... | [
{
"id": "847",
"normalized": [
{
"db_id": "D003324",
"db_name": "MESH"
}
],
"offsets": [
[
186,
209
]
],
"text": [
"coronary artery disease"
],
"type": "Disease"
},
{
"id": "848",
"normalized": [
{
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"diltiazem",
"diltiazem",
"metoprolol",
"metoprolol",
"diltiazem",
"metoprolol",
"sparteine",
"debrisoquine",
"propafenone",
"diltiazem",
"debrisoquine",
"sparteine"
] | [
"hypotension",
"impairment of ventricular function",
"impairment of ventricular function",
"hypotension",
"AV block",
"AV block",
"shock",
"impairment of ventricular function",
"adverse drug reactions",
"adverse drug reactions",
"shock",
"impairment of ventricular function"
] | [
{
"id": "850",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
270,
281
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "851",
"normalized": [
{
"db_id": "... | [
{
"id": "845",
"normalized": [
{
"db_id": "D004110",
"db_name": "MESH"
}
],
"offsets": [
[
123,
132
]
],
"text": [
"diltiazem"
],
"type": "Chemical"
},
{
"id": "845",
"normalized": [
{
"db_id": "D... | [
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false
] |
Triazolam-induced brief episodes of secondary mania in a depressed patient. | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | [
{
"id": "892",
"normalized": [
{
"db_id": "D014229",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Triazolam"
],
"type": "Chemical"
},
{
"id": "895",
"normalized": [
{
"db_id": "D0142... | [
{
"id": "893",
"normalized": [
{
"db_id": "D001714",
"db_name": "MESH"
}
],
"offsets": [
[
46,
51
]
],
"text": [
"mania"
],
"type": "Disease"
},
{
"id": "894",
"normalized": [
{
"db_id": "D003866"... | [
"Yes",
"No"
] | [
"Triazolam",
"Triazolam"
] | [
"mania",
"organic mental disorder"
] | [
{
"id": "893",
"normalized": [
{
"db_id": "D001714",
"db_name": "MESH"
}
],
"offsets": [
[
46,
51
]
],
"text": [
"mania"
],
"type": "Disease"
},
{
"id": "898",
"normalized": [
{
"db_id": "D019965"... | [
{
"id": "892",
"normalized": [
{
"db_id": "D014229",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Triazolam"
],
"type": "Chemical"
},
{
"id": "892",
"normalized": [
{
"db_id": "D0142... | [
true,
false
] |
On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | [
{
"id": "919",
"normalized": [
{
"db_id": "D009020",
"db_name": "MESH"
}
],
"offsets": [
[
87,
95
]
],
"text": [
"morphine"
],
"type": "Chemical"
},
{
"id": "921",
"normalized": [
{
"db_id": "D009... | [
{
"id": "918",
"normalized": [
{
"db_id": "D009127",
"db_name": "MESH"
}
],
"offsets": [
[
57,
74
]
],
"text": [
"muscular rigidity"
],
"type": "Disease"
},
{
"id": "920",
"normalized": [
{
"db_id... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No"
] | [
"haloperidol",
"morphine",
"morphine",
"morphine",
"haloperidol",
"haloperidol"
] | [
"muscular rigidity",
"muscular rigidity",
"hyperkinetic",
"akinetic",
"hyperkinetic",
"akinetic"
] | [
{
"id": "918",
"normalized": [
{
"db_id": "D009127",
"db_name": "MESH"
}
],
"offsets": [
[
57,
74
]
],
"text": [
"muscular rigidity"
],
"type": "Disease"
},
{
"id": "918",
"normalized": [
{
"db_id... | [
{
"id": "932",
"normalized": [
{
"db_id": "D006220",
"db_name": "MESH"
}
],
"offsets": [
[
976,
987
]
],
"text": [
"haloperidol"
],
"type": "Chemical"
},
{
"id": "919",
"normalized": [
{
"db_id": ... | [
true,
true,
false,
true,
false,
false
] |
Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy. | Fibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy has not previously been reported. In a 37-year-old woman with documented pentazocine-induced fibrous myopathy of triceps and deltoid mus... | [
{
"id": "1043",
"normalized": [
{
"db_id": "D010423",
"db_name": "MESH"
}
],
"offsets": [
[
50,
61
]
],
"text": [
"pentazocine"
],
"type": "Chemical"
},
{
"id": "1046",
"normalized": [
{
"db_id": ... | [
{
"id": "1040",
"normalized": [
{
"db_id": "D009408",
"db_name": "MESH"
},
{
"db_id": "D020425",
"db_name": "MESH"
}
],
"offsets": [
[
0,
42
]
],
"text": [
"Compression neuropathy of the radial nerve"
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes"
] | [
"pentazocine",
"pentazocine",
"pentazocine",
"pentazocine",
"pentazocine"
] | [
"fibrous myopathy",
"myopathy",
"Compression neuropathy of the radial nerve",
"neuropathy of the radial nerve",
"Compression neuropathy"
] | [
{
"id": "1044",
"normalized": [
{
"db_id": "D005355",
"db_name": "MESH"
},
{
"db_id": "D009135",
"db_name": "MESH"
}
],
"offsets": [
[
70,
86
]
],
"text": [
"fibrous myopathy"
],
"type": "Diseas... | [
{
"id": "1043",
"normalized": [
{
"db_id": "D010423",
"db_name": "MESH"
}
],
"offsets": [
[
50,
61
]
],
"text": [
"pentazocine"
],
"type": "Chemical"
},
{
"id": "1043",
"normalized": [
{
"db_id": ... | [
true,
true,
true,
true,
true
] |
Recurrent reversible acute renal failure from amphotericin. | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | [
{
"id": "1113",
"normalized": [
{
"db_id": "D000666",
"db_name": "MESH"
}
],
"offsets": [
[
46,
58
]
],
"text": [
"amphotericin"
],
"type": "Chemical"
},
{
"id": "1117",
"normalized": [
{
"db_id":... | [
{
"id": "1112",
"normalized": [
{
"db_id": "D058186",
"db_name": "MESH"
}
],
"offsets": [
[
21,
40
]
],
"text": [
"acute renal failure"
],
"type": "Disease"
},
{
"id": "1114",
"normalized": [
{
"d... | [
"Yes",
"No"
] | [
"amphotericin",
"amphotericin"
] | [
"acute renal failure",
"renal failure"
] | [
{
"id": "1112",
"normalized": [
{
"db_id": "D058186",
"db_name": "MESH"
}
],
"offsets": [
[
21,
40
]
],
"text": [
"acute renal failure"
],
"type": "Disease"
},
{
"id": "1118",
"normalized": [
{
"d... | [
{
"id": "1113",
"normalized": [
{
"db_id": "D000666",
"db_name": "MESH"
}
],
"offsets": [
[
46,
58
]
],
"text": [
"amphotericin"
],
"type": "Chemical"
},
{
"id": "1113",
"normalized": [
{
"db_id":... | [
true,
false
] |
Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | [
{
"id": "1138",
"normalized": [
{
"db_id": "D000638",
"db_name": "MESH"
}
],
"offsets": [
[
72,
82
]
],
"text": [
"amiodarone"
],
"type": "Chemical"
},
{
"id": "1140",
"normalized": [
{
"db_id": "... | [
{
"id": "1134",
"normalized": [
{
"db_id": "D010996",
"db_name": "MESH"
},
{
"db_id": "D010490",
"db_name": "MESH"
}
],
"offsets": [
[
17,
49
]
],
"text": [
"pleural and pericardial effusion"
],
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No"
] | [
"amiodarone",
"amiodarone",
"amiodarone",
"amiodarone",
"amiodarone",
"steroid",
"steroid",
"prednisolone",
"steroid",
"prednisolone"
] | [
"pleural and pericardial effusion",
"pericardial effusion",
"proximal motor neuropathy",
"pleural",
"pneumonitis",
"pneumonitis",
"sinuatrial disease",
"sinuatrial disease",
"pleural",
"pericardial effusion"
] | [
{
"id": "1134",
"normalized": [
{
"db_id": "D010996",
"db_name": "MESH"
},
{
"db_id": "D010490",
"db_name": "MESH"
}
],
"offsets": [
[
17,
49
]
],
"text": [
"pleural and pericardial effusion"
],
... | [
{
"id": "1138",
"normalized": [
{
"db_id": "D000638",
"db_name": "MESH"
}
],
"offsets": [
[
72,
82
]
],
"text": [
"amiodarone"
],
"type": "Chemical"
},
{
"id": "1138",
"normalized": [
{
"db_id": "... | [
true,
true,
false,
true,
true,
true,
false,
false,
false,
false
] |
Indomethacin-induced renal insufficiency: recurrence on rechallenge. | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | [
{
"id": "1211",
"normalized": [
{
"db_id": "D007213",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Indomethacin"
],
"type": "Chemical"
},
{
"id": "1218",
"normalized": [
{
"db_id": ... | [
{
"id": "1212",
"normalized": [
{
"db_id": "D051437",
"db_name": "MESH"
}
],
"offsets": [
[
21,
40
]
],
"text": [
"renal insufficiency"
],
"type": "Disease"
},
{
"id": "1213",
"normalized": [
{
"d... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"Indomethacin",
"Indomethacin",
"Indomethacin",
"Indomethacin",
"Indomethacin",
"Indomethacin",
"prostaglandins",
"prostaglandins",
"prostaglandins",
"prostaglandins",
"Indomethacin",
"prostaglandins"
] | [
"hyperkalemia",
"oliguria",
"acute renal failure",
"cirrhosis",
"ascites",
"cor pulmonale",
"ascites",
"hyperkalemia",
"oliguria",
"cirrhosis",
"renal insufficiency",
"renal insufficiency"
] | [
{
"id": "1214",
"normalized": [
{
"db_id": "D006947",
"db_name": "MESH"
}
],
"offsets": [
[
130,
142
]
],
"text": [
"hyperkalemia"
],
"type": "Disease"
},
{
"id": "1220",
"normalized": [
{
"db_id"... | [
{
"id": "1211",
"normalized": [
{
"db_id": "D007213",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Indomethacin"
],
"type": "Chemical"
},
{
"id": "1211",
"normalized": [
{
"db_id": ... | [
true,
true,
false,
true,
true,
true,
false,
false,
false,
false,
true,
false
] |
Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers. | Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chromatography, in a smaller number of the subjects. The most striking effect was sedation which increased with the dose, 2 mg producing ... | [
{
"id": "1244",
"normalized": [
{
"db_id": "D005445",
"db_name": "MESH"
}
],
"offsets": [
[
105,
118
]
],
"text": [
"flunitrazepam"
],
"type": "Chemical"
},
{
"id": "1245",
"normalized": [
{
"db_i... | [
{
"id": "1246",
"normalized": [
{
"db_id": "D004244",
"db_name": "MESH"
}
],
"offsets": [
[
638,
647
]
],
"text": [
"Dizziness"
],
"type": "Disease"
},
{
"id": "1247",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes"
] | [
"flunitrazepam",
"flunitrazepam"
] | [
"Dizziness",
"pain"
] | [
{
"id": "1246",
"normalized": [
{
"db_id": "D004244",
"db_name": "MESH"
}
],
"offsets": [
[
638,
647
]
],
"text": [
"Dizziness"
],
"type": "Disease"
},
{
"id": "1247",
"normalized": [
{
"db_id": "... | [
{
"id": "1244",
"normalized": [
{
"db_id": "D005445",
"db_name": "MESH"
}
],
"offsets": [
[
105,
118
]
],
"text": [
"flunitrazepam"
],
"type": "Chemical"
},
{
"id": "1244",
"normalized": [
{
"db_i... | [
false,
false
] |
Changes in heart size during long-term timolol treatment after myocardial infarction. | The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in co... | [
{
"id": "1258",
"normalized": [
{
"db_id": "D013999",
"db_name": "MESH"
}
],
"offsets": [
[
39,
46
]
],
"text": [
"timolol"
],
"type": "Chemical"
},
{
"id": "1260",
"normalized": [
{
"db_id": "D01... | [
{
"id": "1259",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
63,
84
]
],
"text": [
"myocardial infarction"
],
"type": "Disease"
},
{
"id": "1261",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"timolol",
"timolol"
] | [
"cardiomegaly",
"myocardial infarction"
] | [
{
"id": "1267",
"normalized": [
{
"db_id": "D006332",
"db_name": "MESH"
}
],
"offsets": [
[
694,
706
]
],
"text": [
"cardiomegaly"
],
"type": "Disease"
},
{
"id": "1259",
"normalized": [
{
"db_id"... | [
{
"id": "1258",
"normalized": [
{
"db_id": "D013999",
"db_name": "MESH"
}
],
"offsets": [
[
39,
46
]
],
"text": [
"timolol"
],
"type": "Chemical"
},
{
"id": "1258",
"normalized": [
{
"db_id": "D01... | [
false,
true
] |
Vitamin D3 toxicity in dairy cows. | Large parenteral doses of vitamin D3 (15 to 17.5 x 10(6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the blood plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentrations 1 day postpartum were higher in ... | [
{
"id": "1280",
"normalized": [
{
"db_id": "D002762",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Vitamin D3"
],
"type": "Chemical"
},
{
"id": "1282",
"normalized": [
{
"db_id": "D... | [
{
"id": "1281",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
11,
19
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "1284",
"normalized": [
{
"db_id": "D00... | [
"Yes",
"Yes",
"No",
"No"
] | [
"Vitamin D3",
"Vitamin D3",
"Calcium",
"Calcium"
] | [
"hypercalcemia",
"hyperphosphatemia",
"toxicity",
"hypercalcemia"
] | [
{
"id": "1284",
"normalized": [
{
"db_id": "D006934",
"db_name": "MESH"
}
],
"offsets": [
[
138,
151
]
],
"text": [
"hypercalcemia"
],
"type": "Disease"
},
{
"id": "1285",
"normalized": [
{
"db_id... | [
{
"id": "1280",
"normalized": [
{
"db_id": "D002762",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Vitamin D3"
],
"type": "Chemical"
},
{
"id": "1280",
"normalized": [
{
"db_id": "D... | [
true,
true,
false,
false
] |
Diseases of peripheral nerves as seen in the Nigerian African. | The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen in 358 Nigerians are presented. There is a male preponderance and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr ... | [
{
"id": "1335",
"normalized": [
{
"db_id": "D013831",
"db_name": "MESH"
}
],
"offsets": [
[
550,
558
]
],
"text": [
"thiamine"
],
"type": "Chemical"
},
{
"id": "1336",
"normalized": [
{
"db_id": "... | [
{
"id": "1328",
"normalized": [
{
"db_id": "D010523",
"db_name": "MESH"
}
],
"offsets": [
[
0,
29
]
],
"text": [
"Diseases of peripheral nerves"
],
"type": "Disease"
},
{
"id": "1329",
"normalized": [
{
... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"riboflavin",
"thiamine",
"Isoniazid",
"Isoniazid",
"thiamine",
"thiamine"
] | [
"Diseases of peripheral nerves",
"Diseases of peripheral nerves",
"Diseases of peripheral nerves",
"cranial neuropathy",
"Migraine",
"autonomic neuropathy"
] | [
{
"id": "1328",
"normalized": [
{
"db_id": "D010523",
"db_name": "MESH"
}
],
"offsets": [
[
0,
29
]
],
"text": [
"Diseases of peripheral nerves"
],
"type": "Disease"
},
{
"id": "1328",
"normalized": [
{
... | [
{
"id": "1336",
"normalized": [
{
"db_id": "D012256",
"db_name": "MESH"
}
],
"offsets": [
[
563,
573
]
],
"text": [
"riboflavin"
],
"type": "Chemical"
},
{
"id": "1335",
"normalized": [
{
"db_id":... | [
true,
true,
false,
false,
false,
false
] |
A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder. | In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective in alleviating the symptoms of depressive illness, and both were significantly superior to placebo. The overall inciden... | [
{
"id": "1369",
"normalized": [
{
"db_id": "D004308",
"db_name": "MESH"
}
],
"offsets": [
[
51,
74
]
],
"text": [
"dothiepin hydrochloride"
],
"type": "Chemical"
},
{
"id": "1371",
"normalized": [
{
... | [
{
"id": "1370",
"normalized": [
{
"db_id": "D003866",
"db_name": "MESH"
}
],
"offsets": [
[
101,
120
]
],
"text": [
"depressive disorder"
],
"type": "Disease"
},
{
"id": "1373",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"amitriptyline",
"amitriptyline",
"antidepressant",
"antidepressant"
] | [
"blurred vision",
"dry mouth",
"dry mouth",
"blurred vision"
] | [
{
"id": "1377",
"normalized": [
{
"db_id": "D014786",
"db_name": "MESH"
}
],
"offsets": [
[
495,
509
]
],
"text": [
"blurred vision"
],
"type": "Disease"
},
{
"id": "1378",
"normalized": [
{
"db_i... | [
{
"id": "1372",
"normalized": [
{
"db_id": "D000639",
"db_name": "MESH"
}
],
"offsets": [
[
187,
200
]
],
"text": [
"amitriptyline"
],
"type": "Chemical"
},
{
"id": "1372",
"normalized": [
{
"db_i... | [
true,
true,
false,
false
] |
Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia. | The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and cro... | [
{
"id": "1397",
"normalized": [
{
"db_id": "D003975",
"db_name": "MESH"
}
],
"offsets": [
[
22,
30
]
],
"text": [
"diazepam"
],
"type": "Chemical"
},
{
"id": "1398",
"normalized": [
{
"db_id": "D0... | [
{
"id": "1399",
"normalized": [
{
"db_id": "D016584",
"db_name": "MESH"
}
],
"offsets": [
[
64,
78
]
],
"text": [
"panic disorder"
],
"type": "Disease"
},
{
"id": "1400",
"normalized": [
{
"db_id"... | [
"Yes",
"Yes",
"No",
"No"
] | [
"propranolol",
"diazepam",
"propranolol",
"diazepam"
] | [
"impaired immediate free recall",
"impaired immediate free recall",
"behavioral impairment",
"behavioral impairment"
] | [
{
"id": "1405",
"normalized": [
{
"db_id": "D008569",
"db_name": "MESH"
}
],
"offsets": [
[
442,
472
]
],
"text": [
"impaired immediate free recall"
],
"type": "Disease"
},
{
"id": "1405",
"normalized": [
... | [
{
"id": "1398",
"normalized": [
{
"db_id": "D011433",
"db_name": "MESH"
}
],
"offsets": [
[
35,
46
]
],
"text": [
"propranolol"
],
"type": "Chemical"
},
{
"id": "1397",
"normalized": [
{
"db_id": ... | [
true,
true,
false,
false
] |
Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat. | The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradiographic study was performed on male F-344 rats fed diet containing FANFT at a level of 0.... | [
{
"id": "1437",
"normalized": [
{
"db_id": "D001241",
"db_name": "MESH"
}
],
"offsets": [
[
10,
17
]
],
"text": [
"aspirin"
],
"type": "Chemical"
},
{
"id": "1438",
"normalized": [
{
"db_id": "D00... | [
{
"id": "1443",
"normalized": [
{
"db_id": "D001749",
"db_name": "MESH"
}
],
"offsets": [
[
300,
318
]
],
"text": [
"bladder carcinomas"
],
"type": "Disease"
},
{
"id": "1444",
"normalized": [
{
"... | [
"Yes",
"Yes",
"No",
"No"
] | [
"N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide",
"N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide",
"aspirin",
"aspirin"
] | [
"bladder carcinomas",
"forestomach tumors",
"carcinogenesis",
"bladder carcinomas"
] | [
{
"id": "1443",
"normalized": [
{
"db_id": "D001749",
"db_name": "MESH"
}
],
"offsets": [
[
300,
318
]
],
"text": [
"bladder carcinomas"
],
"type": "Disease"
},
{
"id": "1444",
"normalized": [
{
"... | [
{
"id": "1438",
"normalized": [
{
"db_id": "D005200",
"db_name": "MESH"
}
],
"offsets": [
[
21,
66
]
],
"text": [
"N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide"
],
"type": "Chemical"
},
{
"id": "1438",
"normal... | [
true,
true,
true,
true
] |
Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy? | The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitude and time course of the increase in heart rate and the decrease in systolic blood pressure after nit... | [
{
"id": "1482",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
39,
52
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "1484",
"normalized": [
{
"db_id"... | [
{
"id": "1481",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
24,
35
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "1483",
"normalized": [
{
"db_id": "... | [
"Yes",
"No"
] | [
"nitroglycerin",
"nitroglycerin"
] | [
"hypotension",
"diabetic"
] | [
{
"id": "1481",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
24,
35
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "1485",
"normalized": [
{
"db_id": "... | [
{
"id": "1482",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
39,
52
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "1482",
"normalized": [
{
"db_id"... | [
true,
true
] |
Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat. | Pituitary tumors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. Over a range of 1-150 days of DES treatment, pairs of control and DES-treated rats were sacrificed, and their pituitaries dissociated enzymatically into single-cel... | [
{
"id": "1502",
"normalized": [
{
"db_id": "D004967",
"db_name": "MESH"
}
],
"offsets": [
[
20,
28
]
],
"text": [
"estrogen"
],
"type": "Chemical"
},
{
"id": "1505",
"normalized": [
{
"db_id": "D0... | [
{
"id": "1503",
"normalized": [
{
"db_id": "D010911",
"db_name": "MESH"
}
],
"offsets": [
[
37,
60
]
],
"text": [
"adenohypophyseal tumors"
],
"type": "Disease"
},
{
"id": "1504",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"diethylstilbestrol",
"estrogen"
] | [
"adenohypophyseal tumors",
"adenohypophyseal tumors"
] | [
{
"id": "1503",
"normalized": [
{
"db_id": "D010911",
"db_name": "MESH"
}
],
"offsets": [
[
37,
60
]
],
"text": [
"adenohypophyseal tumors"
],
"type": "Disease"
},
{
"id": "1503",
"normalized": [
{
... | [
{
"id": "1505",
"normalized": [
{
"db_id": "D004054",
"db_name": "MESH"
}
],
"offsets": [
[
161,
179
]
],
"text": [
"diethylstilbestrol"
],
"type": "Chemical"
},
{
"id": "1502",
"normalized": [
{
... | [
true,
true
] |
Triamterene nephrolithiasis complicating dyazide therapy. | A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a triamterene metabolite admixed with uric acid salts. Factors affecting triamterene nephrolithiasis are discussed and 2 previousl... | [
{
"id": "1537",
"normalized": [
{
"db_id": "D014223",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Triamterene"
],
"type": "Chemical"
},
{
"id": "1539",
"normalized": [
{
"db_id": "... | [
{
"id": "1538",
"normalized": [
{
"db_id": "D053040",
"db_name": "MESH"
}
],
"offsets": [
[
12,
27
]
],
"text": [
"nephrolithiasis"
],
"type": "Disease"
},
{
"id": "1541",
"normalized": [
{
"db_id... | [
"Yes",
"No"
] | [
"Triamterene",
"uric acid salts"
] | [
"nephrolithiasis",
"nephrolithiasis"
] | [
{
"id": "1538",
"normalized": [
{
"db_id": "D053040",
"db_name": "MESH"
}
],
"offsets": [
[
12,
27
]
],
"text": [
"nephrolithiasis"
],
"type": "Disease"
},
{
"id": "1538",
"normalized": [
{
"db_id... | [
{
"id": "1537",
"normalized": [
{
"db_id": "D014223",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Triamterene"
],
"type": "Chemical"
},
{
"id": "1545",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Metabolic involvement in adriamycin cardiotoxicity. | The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteristic of myocardial cells in culture. A possible involvement of energy metabolism was suggested previously, and in this study the adenyla... | [
{
"id": "1563",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
25,
35
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "1566",
"normalized": [
{
"db_id": "... | [
{
"id": "1564",
"normalized": [
{
"db_id": "D066126",
"db_name": "MESH"
}
],
"offsets": [
[
36,
50
]
],
"text": [
"cardiotoxicity"
],
"type": "Disease"
},
{
"id": "1565",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"adriamycin",
"phosphorylcreatine"
] | [
"cardiotoxicity",
"cardiotoxicity"
] | [
{
"id": "1564",
"normalized": [
{
"db_id": "D066126",
"db_name": "MESH"
}
],
"offsets": [
[
36,
50
]
],
"text": [
"cardiotoxicity"
],
"type": "Disease"
},
{
"id": "1564",
"normalized": [
{
"db_id"... | [
{
"id": "1563",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
25,
35
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "1568",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin. | Streptomycin sulfate (300 mg/kg s.c.) was injected for various periods into preweanling rats and for 3 weeks into weanling rats. Beginning at 8 days of age, body movement and hearing were examined for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweaning... | [
{
"id": "1591",
"normalized": [
{
"db_id": "D013307",
"db_name": "MESH"
}
],
"offsets": [
[
62,
74
]
],
"text": [
"streptomycin"
],
"type": "Chemical"
},
{
"id": "1592",
"normalized": [
{
"db_id":... | [
{
"id": "1590",
"normalized": [
{
"db_id": "D020258",
"db_name": "MESH"
}
],
"offsets": [
[
40,
50
]
],
"text": [
"neurotoxic"
],
"type": "Disease"
},
{
"id": "1593",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes",
"No"
] | [
"streptomycin",
"streptomycin",
"streptomycin"
] | [
"Abnormal movements",
"deafness",
"neurotoxic"
] | [
{
"id": "1593",
"normalized": [
{
"db_id": "D004409",
"db_name": "MESH"
}
],
"offsets": [
[
313,
331
]
],
"text": [
"Abnormal movements"
],
"type": "Disease"
},
{
"id": "1594",
"normalized": [
{
"... | [
{
"id": "1591",
"normalized": [
{
"db_id": "D013307",
"db_name": "MESH"
}
],
"offsets": [
[
62,
74
]
],
"text": [
"streptomycin"
],
"type": "Chemical"
},
{
"id": "1591",
"normalized": [
{
"db_id":... | [
true,
true,
true
] |
Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis. | This case study reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this disease. This patient underwent a 10-month regimen of rifampin and isoniazid for pulmonary tuberculosis and was discovered to have... | [
{
"id": "1610",
"normalized": [
{
"db_id": "D012293",
"db_name": "MESH"
}
],
"offsets": [
[
70,
78
]
],
"text": [
"rifampin"
],
"type": "Chemical"
},
{
"id": "1613",
"normalized": [
{
"db_id": "D0... | [
{
"id": "1609",
"normalized": [
{
"db_id": "D005921",
"db_name": "MESH"
}
],
"offsets": [
[
22,
40
]
],
"text": [
"glomerulonephritis"
],
"type": "Disease"
},
{
"id": "1611",
"normalized": [
{
"db... | [
"Yes",
"Yes",
"No",
"No"
] | [
"rifampin",
"rifampin",
"isoniazid",
"isoniazid"
] | [
"glomerulonephritis",
"renal failure",
"glomerulonephritis",
"pulmonary tuberculosis"
] | [
{
"id": "1609",
"normalized": [
{
"db_id": "D005921",
"db_name": "MESH"
}
],
"offsets": [
[
22,
40
]
],
"text": [
"glomerulonephritis"
],
"type": "Disease"
},
{
"id": "1617",
"normalized": [
{
"db... | [
{
"id": "1610",
"normalized": [
{
"db_id": "D012293",
"db_name": "MESH"
}
],
"offsets": [
[
70,
78
]
],
"text": [
"rifampin"
],
"type": "Chemical"
},
{
"id": "1610",
"normalized": [
{
"db_id": "D0... | [
true,
true,
false,
true
] |
Time course of lipid peroxidation in puromycin aminonucleoside-induced nephropathy. | Reactive oxygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxidation in the kidney and proteinuria was examined in this study. Rats were treated with a... | [
{
"id": "1654",
"normalized": [
{
"db_id": "D011692",
"db_name": "MESH"
}
],
"offsets": [
[
37,
62
]
],
"text": [
"puromycin aminonucleoside"
],
"type": "Chemical"
},
{
"id": "1656",
"normalized": [
{
... | [
{
"id": "1655",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
71,
82
]
],
"text": [
"nephropathy"
],
"type": "Disease"
},
{
"id": "1659",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"puromycin aminonucleoside",
"puromycin aminonucleoside",
"oxygen",
"thiobarbituric acid"
] | [
"nephropathy",
"proteinuria",
"nephropathy",
"proteinuria"
] | [
{
"id": "1655",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
71,
82
]
],
"text": [
"nephropathy"
],
"type": "Disease"
},
{
"id": "1660",
"normalized": [
{
"db_id": "... | [
{
"id": "1654",
"normalized": [
{
"db_id": "D011692",
"db_name": "MESH"
}
],
"offsets": [
[
37,
62
]
],
"text": [
"puromycin aminonucleoside"
],
"type": "Chemical"
},
{
"id": "1654",
"normalized": [
{
... | [
true,
true,
true,
false
] |
Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action. | The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in addition to the direct drug effect. Two groups of supine subjects were studied under placebo-controlled conditions, one during the night, when sleeping (n = 7) a... | [
{
"id": "1714",
"normalized": [
{
"db_id": "D002997",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Clomipramine"
],
"type": "Chemical"
},
{
"id": "1717",
"normalized": [
{
"db_id": ... | [
{
"id": "1715",
"normalized": [
{
"db_id": "D012893",
"db_name": "MESH"
}
],
"offsets": [
[
21,
38
]
],
"text": [
"sleep disturbance"
],
"type": "Disease"
},
{
"id": "1716",
"normalized": [
{
"db_... | [
"Yes"
] | [
"Clomipramine"
] | [
"sleep disturbance"
] | [
{
"id": "1715",
"normalized": [
{
"db_id": "D012893",
"db_name": "MESH"
}
],
"offsets": [
[
21,
38
]
],
"text": [
"sleep disturbance"
],
"type": "Disease"
}
] | [
{
"id": "1714",
"normalized": [
{
"db_id": "D002997",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Clomipramine"
],
"type": "Chemical"
}
] | [
true
] |
Angioedema following the intravenous administration of metoprolol. | A 72-year-old woman was admitted to the hospital with "flash" pulmonary edema, preceded by chest pain, requiring intubation. Her medical history included coronary artery disease with previous myocardial infarctions, hypertension, and diabetes mellitus. A history of angioedema secondary to lisinopril therapy was elicite... | [
{
"id": "1741",
"normalized": [
{
"db_id": "D008790",
"db_name": "MESH"
}
],
"offsets": [
[
55,
65
]
],
"text": [
"metoprolol"
],
"type": "Chemical"
},
{
"id": "1749",
"normalized": [
{
"db_id": "... | [
{
"id": "1740",
"normalized": [
{
"db_id": "D000799",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Angioedema"
],
"type": "Disease"
},
{
"id": "1742",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"Yes",
"No",
"No"
] | [
"metoprolol",
"lisinopril",
"diphenhydramine",
"steroids"
] | [
"Angioedema",
"Angioedema",
"chest pain",
"Angioedema"
] | [
{
"id": "1740",
"normalized": [
{
"db_id": "D000799",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Angioedema"
],
"type": "Disease"
},
{
"id": "1740",
"normalized": [
{
"db_id": "D0... | [
{
"id": "1741",
"normalized": [
{
"db_id": "D008790",
"db_name": "MESH"
}
],
"offsets": [
[
55,
65
]
],
"text": [
"metoprolol"
],
"type": "Chemical"
},
{
"id": "1749",
"normalized": [
{
"db_id": "... | [
true,
true,
false,
true
] |
Effect of coniine on the developing chick embryo. | Coniine, an alkaloid from Conium maculatum (poison hemlock), has been shown to be teratogenic in livestock. The major teratogenic outcome is arthrogryposis, presumably due to nicotinic receptor blockade. However, coniine has failed to produce arthrogryposis in rats or mice and is only weakly teratogenic in rabbits. The... | [
{
"id": "1771",
"normalized": [
{
"db_id": "C007112",
"db_name": "MESH"
}
],
"offsets": [
[
10,
17
]
],
"text": [
"coniine"
],
"type": "Chemical"
},
{
"id": "1772",
"normalized": [
{
"db_id": "C00... | [
{
"id": "1773",
"normalized": [
{
"db_id": "D001176",
"db_name": "MESH"
}
],
"offsets": [
[
191,
205
]
],
"text": [
"arthrogryposis"
],
"type": "Disease"
},
{
"id": "1775",
"normalized": [
{
"db_i... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"nicotine",
"coniine",
"nicotine",
"coniine",
"nicotine",
"coniine"
] | [
"arthrogryposis",
"arthrogryposis",
"cranial hemorrhage",
"cranial hemorrhage",
"deformations",
"deformations"
] | [
{
"id": "1773",
"normalized": [
{
"db_id": "D001176",
"db_name": "MESH"
}
],
"offsets": [
[
191,
205
]
],
"text": [
"arthrogryposis"
],
"type": "Disease"
},
{
"id": "1773",
"normalized": [
{
"db_i... | [
{
"id": "1777",
"normalized": [
{
"db_id": "D009538",
"db_name": "MESH"
}
],
"offsets": [
[
448,
456
]
],
"text": [
"nicotine"
],
"type": "Chemical"
},
{
"id": "1771",
"normalized": [
{
"db_id": "... | [
false,
true,
true,
false,
true,
true
] |
Epidural blood flow during prostaglandin E1 or trimethaphan induced hypotension. | To evaluate the effect of prostaglandin E1 (PGE1) or trimethaphan (TMP) induced hypotension on epidural blood flow (EBF) during spinal surgery, EBF was measured using the heat clearance method in 30 patients who underwent postero-lateral interbody fusion under isoflurane anaesthesia. An initial dose of 0.1 microgram.kg... | [
{
"id": "1856",
"normalized": [
{
"db_id": "D000527",
"db_name": "MESH"
}
],
"offsets": [
[
27,
43
]
],
"text": [
"prostaglandin E1"
],
"type": "Chemical"
},
{
"id": "1857",
"normalized": [
{
"db_... | [
{
"id": "1858",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
68,
79
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "1863",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No"
] | [
"trimethaphan",
"prostaglandin E1",
"isoflurane"
] | [
"hypotension",
"hypotension",
"hypotension"
] | [
{
"id": "1858",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
68,
79
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "1858",
"normalized": [
{
"db_id": "... | [
{
"id": "1857",
"normalized": [
{
"db_id": "D014294",
"db_name": "MESH"
}
],
"offsets": [
[
47,
59
]
],
"text": [
"trimethaphan"
],
"type": "Chemical"
},
{
"id": "1856",
"normalized": [
{
"db_id":... | [
true,
true,
true
] |
Immunohistochemical studies with antibodies to neurofilament proteins on axonal damage in experimental focal lesions in rat. | Immunohistochemistry with monoclonal antibodies against neurofilament (NF) proteins of middle and high molecular weight class, NF-M and NF-H, was used to study axonal injury in the borderzone of focal lesions in rats. Focal injury in the cortex was produced by infusion of lactate at acid pH or by stab caused by needle ... | [
{
"id": "1970",
"normalized": [
{
"db_id": "D019344",
"db_name": "MESH"
}
],
"offsets": [
[
398,
405
]
],
"text": [
"lactate"
],
"type": "Chemical"
},
{
"id": "1972",
"normalized": [
{
"db_id": "D... | [
{
"id": "1967",
"normalized": [
{
"db_id": "D001480",
"db_name": "MESH"
}
],
"offsets": [
[
73,
86
]
],
"text": [
"axonal damage"
],
"type": "Disease"
},
{
"id": "1968",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"pilocarpine",
"pilocarpine",
"pilocarpine",
"lactate",
"lactate",
"lactate"
] | [
"status epilepticus",
"Infarcts in substantia nigra pars reticulata",
"axonal damage",
"Infarcts in substantia nigra pars reticulata",
"traumatic",
"status epilepticus"
] | [
{
"id": "1973",
"normalized": [
{
"db_id": "D013226",
"db_name": "MESH"
}
],
"offsets": [
[
546,
564
]
],
"text": [
"status epilepticus"
],
"type": "Disease"
},
{
"id": "1971",
"normalized": [
{
"... | [
{
"id": "1972",
"normalized": [
{
"db_id": "D010862",
"db_name": "MESH"
}
],
"offsets": [
[
526,
537
]
],
"text": [
"pilocarpine"
],
"type": "Chemical"
},
{
"id": "1972",
"normalized": [
{
"db_id"... | [
true,
true,
false,
false,
false,
false
] |
Increase of Parkinson disability after fluoxetine medication. | Depression is a major clinical feature of Parkinson's disease. We report the increased amount of motor disability in four patients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine. The possibility of a clinically relevant dopamine-antagonistic capacity of fluoxetine in Parkinson's dis... | [
{
"id": "1986",
"normalized": [
{
"db_id": "D005473",
"db_name": "MESH"
}
],
"offsets": [
[
39,
49
]
],
"text": [
"fluoxetine"
],
"type": "Chemical"
},
{
"id": "1991",
"normalized": [
{
"db_id": "... | [
{
"id": "1985",
"normalized": [
{
"db_id": "D009069",
"db_name": "MESH"
}
],
"offsets": [
[
12,
32
]
],
"text": [
"Parkinson disability"
],
"type": "Disease"
},
{
"id": "1987",
"normalized": [
{
"... | [
"Yes",
"No"
] | [
"fluoxetine",
"antidepressant"
] | [
"Parkinson disability",
"Parkinson disability"
] | [
{
"id": "1985",
"normalized": [
{
"db_id": "D009069",
"db_name": "MESH"
}
],
"offsets": [
[
12,
32
]
],
"text": [
"Parkinson disability"
],
"type": "Disease"
},
{
"id": "1985",
"normalized": [
{
"... | [
{
"id": "1986",
"normalized": [
{
"db_id": "D005473",
"db_name": "MESH"
}
],
"offsets": [
[
39,
49
]
],
"text": [
"fluoxetine"
],
"type": "Chemical"
},
{
"id": "1991",
"normalized": [
{
"db_id": "... | [
true,
true
] |
Acetaminophen-induced hypotension. | Through 30 years of widespread use, acetaminophen has been shown to be a remarkably safe medication in therapeutic dosages. The potential for acetaminophen to produce cardiovascular toxicities is very low. However, acetaminophen has been demonstrated to produce symptoms of anaphylaxis, including hypotension, in sensiti... | [
{
"id": "2005",
"normalized": [
{
"db_id": "D000082",
"db_name": "MESH"
}
],
"offsets": [
[
0,
13
]
],
"text": [
"Acetaminophen"
],
"type": "Chemical"
},
{
"id": "2007",
"normalized": [
{
"db_id":... | [
{
"id": "2006",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
22,
33
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "2009",
"normalized": [
{
"db_id": "... | [
"Yes",
"No"
] | [
"Acetaminophen",
"Acetaminophen"
] | [
"hypotension",
"cardiovascular toxicities"
] | [
{
"id": "2006",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
22,
33
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "2009",
"normalized": [
{
"db_id": "... | [
{
"id": "2005",
"normalized": [
{
"db_id": "D000082",
"db_name": "MESH"
}
],
"offsets": [
[
0,
13
]
],
"text": [
"Acetaminophen"
],
"type": "Chemical"
},
{
"id": "2005",
"normalized": [
{
"db_id":... | [
true,
true
] |
Acute hepatitis, autoimmune hemolytic anemia, and erythroblastocytopenia induced by ceftriaxone. | An 80-yr-old man developed acute hepatitis shortly after ingesting oral ceftriaxone. Although the transaminases gradually returned to baseline after withholding the beta lactam antibiotic, there was a gradual increase in serum bilirubin and a decrease in hemoglobin concentration caused by an autoimmune hemolytic anemia... | [
{
"id": "2056",
"normalized": [
{
"db_id": "D002443",
"db_name": "MESH"
}
],
"offsets": [
[
84,
95
]
],
"text": [
"ceftriaxone"
],
"type": "Chemical"
},
{
"id": "2058",
"normalized": [
{
"db_id": ... | [
{
"id": "2053",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
}
],
"offsets": [
[
6,
15
]
],
"text": [
"hepatitis"
],
"type": "Disease"
},
{
"id": "2054",
"normalized": [
{
"db_id": "D00... | [
"Yes",
"Yes",
"No",
"No"
] | [
"ceftriaxone",
"ceftriaxone",
"steroids",
"bilirubin"
] | [
"autoimmune hemolytic anemia",
"hepatitis",
"hepatitis",
"autoimmune hemolytic anemia"
] | [
{
"id": "2054",
"normalized": [
{
"db_id": "D000744",
"db_name": "MESH"
}
],
"offsets": [
[
17,
44
]
],
"text": [
"autoimmune hemolytic anemia"
],
"type": "Disease"
},
{
"id": "2053",
"normalized": [
{
... | [
{
"id": "2056",
"normalized": [
{
"db_id": "D002443",
"db_name": "MESH"
}
],
"offsets": [
[
84,
95
]
],
"text": [
"ceftriaxone"
],
"type": "Chemical"
},
{
"id": "2056",
"normalized": [
{
"db_id": ... | [
true,
true,
false,
true
] |
Adverse effects of the atypical antipsychotics. Collaborative Working Group on Clinical Trial Evaluations. | Adverse effects of antipsychotics often lead to noncompliance. Thus, clinicians should address patients' concerns about adverse effects and attempt to choose medications that will improve their patients' quality of life as well as overall health. The side effect profiles of the atypical antipsychotics are more advantag... | [
{
"id": "2086",
"normalized": [
{
"db_id": "D003024",
"db_name": "MESH"
}
],
"offsets": [
[
1059,
1068
]
],
"text": [
"clozapine"
],
"type": "Chemical"
},
{
"id": "2088",
"normalized": [
{
"db_id"... | [
{
"id": "2076",
"normalized": [
{
"db_id": "D001480",
"db_name": "MESH"
}
],
"offsets": [
[
568,
591
]
],
"text": [
"extrapyramidal symptoms"
],
"type": "Disease"
},
{
"id": "2077",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"clozapine",
"clozapine"
] | [
"agranulocytosis",
"seizure"
] | [
{
"id": "2087",
"normalized": [
{
"db_id": "D000380",
"db_name": "MESH"
}
],
"offsets": [
[
1075,
1090
]
],
"text": [
"agranulocytosis"
],
"type": "Disease"
},
{
"id": "2085",
"normalized": [
{
"d... | [
{
"id": "2086",
"normalized": [
{
"db_id": "D003024",
"db_name": "MESH"
}
],
"offsets": [
[
1059,
1068
]
],
"text": [
"clozapine"
],
"type": "Chemical"
},
{
"id": "2086",
"normalized": [
{
"db_id"... | [
true,
true
] |
Effects of tetrandrine and fangchinoline on experimental thrombosis in mice and human platelet aggregation. | Tetrandrine (TET) and fangchinoline (FAN) are two naturally occurring analogues with a bisbenzylisoquinoline structure. The present study was undertaken to investigate the effects of TET and FAN on the experimental thrombosis induced by collagen plus epinephrine (EP) in mice, and platelet aggregation and blood coagulat... | [
{
"id": "2094",
"normalized": [
{
"db_id": "C009438",
"db_name": "MESH"
}
],
"offsets": [
[
11,
22
]
],
"text": [
"tetrandrine"
],
"type": "Chemical"
},
{
"id": "2095",
"normalized": [
{
"db_id": ... | [
{
"id": "2096",
"normalized": [
{
"db_id": "D013927",
"db_name": "MESH"
}
],
"offsets": [
[
57,
67
]
],
"text": [
"thrombosis"
],
"type": "Disease"
},
{
"id": "2097",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"epinephrine",
"fangchinoline"
] | [
"thrombosis",
"thrombosis"
] | [
{
"id": "2096",
"normalized": [
{
"db_id": "D013927",
"db_name": "MESH"
}
],
"offsets": [
[
57,
67
]
],
"text": [
"thrombosis"
],
"type": "Disease"
},
{
"id": "2096",
"normalized": [
{
"db_id": "D... | [
{
"id": "2106",
"normalized": [
{
"db_id": "D004837",
"db_name": "MESH"
}
],
"offsets": [
[
359,
370
]
],
"text": [
"epinephrine"
],
"type": "Chemical"
},
{
"id": "2095",
"normalized": [
{
"db_id"... | [
true,
true
] |
Gemcitabine plus vinorelbine in nonsmall cell lung carcinoma patients age 70 years or older or patients who cannot receive cisplatin. Oncopaz Cooperative Group. | BACKGROUND: Although the prevalence of nonsmall cell lung carcinoma (NSCLC) is high among elderly patients, few data are available regarding the efficacy and toxicity of chemotherapy in this group of patients. Recent reports indicate that single agent therapy with vinorelbine (VNB) or gemcitabine (GEM) may obtain a res... | [
{
"id": "2131",
"normalized": [
{
"db_id": "C056507",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Gemcitabine"
],
"type": "Chemical"
},
{
"id": "2132",
"normalized": [
{
"db_id": "... | [
{
"id": "2133",
"normalized": [
{
"db_id": "D002289",
"db_name": "MESH"
}
],
"offsets": [
[
32,
60
]
],
"text": [
"nonsmall cell lung carcinoma"
],
"type": "Disease"
},
{
"id": "2135",
"normalized": [
{
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"Gemcitabine",
"vinorelbine",
"Gemcitabine",
"vinorelbine",
"Gemcitabine",
"vinorelbine",
"vinorelbine",
"cisplatin",
"cisplatin",
"cisplatin",
"Gemcitabine",
"cisplatin"
] | [
"thrombocytopenia",
"thrombocytopenia",
"neurotoxicity",
"neutropenia",
"neutropenia",
"neurotoxicity",
"nonsmall cell lung carcinoma",
"myelosuppression",
"thrombocytopenia",
"sepsis",
"myelosuppression",
"toxicity"
] | [
{
"id": "2155",
"normalized": [
{
"db_id": "D013921",
"db_name": "MESH"
}
],
"offsets": [
[
1916,
1932
]
],
"text": [
"thrombocytopenia"
],
"type": "Disease"
},
{
"id": "2155",
"normalized": [
{
"... | [
{
"id": "2131",
"normalized": [
{
"db_id": "C056507",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Gemcitabine"
],
"type": "Chemical"
},
{
"id": "2132",
"normalized": [
{
"db_id": "... | [
false,
false,
false,
false,
false,
false,
true,
false,
false,
false,
false,
true
] |
Warfarin-induced artery calcification is accelerated by growth and vitamin D. | The present studies demonstrate that growth and vitamin D treatment enhance the extent of artery calcification in rats given sufficient doses of Warfarin to inhibit gamma-carboxylation of matrix Gla protein, a calcification inhibitor known to be expressed by smooth muscle cells and macrophages in the artery wall. The f... | [
{
"id": "2228",
"normalized": [
{
"db_id": "D014859",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Warfarin"
],
"type": "Chemical"
},
{
"id": "2230",
"normalized": [
{
"db_id": "D014... | [
{
"id": "2229",
"normalized": [
{
"db_id": "D061205",
"db_name": "MESH"
}
],
"offsets": [
[
17,
37
]
],
"text": [
"artery calcification"
],
"type": "Disease"
},
{
"id": "2232",
"normalized": [
{
"... | [
"Yes",
"No"
] | [
"Warfarin",
"phosphate"
] | [
"artery calcification",
"calcification"
] | [
{
"id": "2229",
"normalized": [
{
"db_id": "D061205",
"db_name": "MESH"
}
],
"offsets": [
[
17,
37
]
],
"text": [
"artery calcification"
],
"type": "Disease"
},
{
"id": "2234",
"normalized": [
{
"... | [
{
"id": "2228",
"normalized": [
{
"db_id": "D014859",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Warfarin"
],
"type": "Chemical"
},
{
"id": "2248",
"normalized": [
{
"db_id": "D010... | [
true,
false
] |
Antidepressant-induced mania in bipolar patients: identification of risk factors. | BACKGROUND: Concerns about possible risks of switching to mania associated with antidepressants continue to interfere with the establishment of an optimal treatment paradigm for bipolar depression. METHOD: The response of 44 patients meeting DSM-IV criteria for bipolar disorder to naturalistic treatment was assessed fo... | [
{
"id": "2579",
"normalized": [
{
"db_id": "D000928",
"db_name": "MESH"
}
],
"offsets": [
[
0,
14
]
],
"text": [
"Antidepressant"
],
"type": "Chemical"
},
{
"id": "2583",
"normalized": [
{
"db_id"... | [
{
"id": "2580",
"normalized": [
{
"db_id": "D001714",
"db_name": "MESH"
}
],
"offsets": [
[
23,
28
]
],
"text": [
"mania"
],
"type": "Disease"
},
{
"id": "2581",
"normalized": [
{
"db_id": "D00171... | [
"Yes",
"Yes",
"No"
] | [
"Antidepressant",
"serotonin reuptake inhibitors",
"lithium"
] | [
"mania",
"mania",
"mania"
] | [
{
"id": "2580",
"normalized": [
{
"db_id": "D001714",
"db_name": "MESH"
}
],
"offsets": [
[
23,
28
]
],
"text": [
"mania"
],
"type": "Disease"
},
{
"id": "2580",
"normalized": [
{
"db_id": "D00171... | [
{
"id": "2579",
"normalized": [
{
"db_id": "D000928",
"db_name": "MESH"
}
],
"offsets": [
[
0,
14
]
],
"text": [
"Antidepressant"
],
"type": "Chemical"
},
{
"id": "2593",
"normalized": [
{
"db_id"... | [
true,
true,
true
] |
Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products. | We describe a 25-year-old woman with pre-existing mitral valve prolapse who developed intractable ventricular fibrillation after consuming a "natural energy" guarana health drink containing a high concentration of caffeine. This case highlights the need for adequate labelling and regulation of such products. | [
{
"id": "2747",
"normalized": [
{
"db_id": "D002110",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Caffeine"
],
"type": "Chemical"
},
{
"id": "2751",
"normalized": [
{
"db_id": "D002... | [
{
"id": "2748",
"normalized": [
{
"db_id": "D001145",
"db_name": "MESH"
}
],
"offsets": [
[
17,
35
]
],
"text": [
"cardiac arrhythmia"
],
"type": "Disease"
},
{
"id": "2749",
"normalized": [
{
"db... | [
"Yes",
"No"
] | [
"Caffeine",
"Caffeine"
] | [
"ventricular fibrillation",
"mitral valve prolapse"
] | [
{
"id": "2750",
"normalized": [
{
"db_id": "D014693",
"db_name": "MESH"
}
],
"offsets": [
[
182,
206
]
],
"text": [
"ventricular fibrillation"
],
"type": "Disease"
},
{
"id": "2749",
"normalized": [
{
... | [
{
"id": "2747",
"normalized": [
{
"db_id": "D002110",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Caffeine"
],
"type": "Chemical"
},
{
"id": "2747",
"normalized": [
{
"db_id": "D002... | [
true,
true
] |
Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports. | Sedation has been commonly used in the neonate to decrease the stress and pain from the noxious stimuli and invasive procedures in the neonatal intensive care unit, as well as to facilitate synchrony between ventilator and spontaneous breaths. Fentanyl, an opioid analgesic, is frequently used in the neonatal intensive ... | [
{
"id": "2758",
"normalized": [
{
"db_id": "D005283",
"db_name": "MESH"
}
],
"offsets": [
[
77,
85
]
],
"text": [
"fentanyl"
],
"type": "Chemical"
},
{
"id": "2760",
"normalized": [
{
"db_id": "D0... | [
{
"id": "2757",
"normalized": [
{
"db_id": "D016055",
"db_name": "MESH"
}
],
"offsets": [
[
8,
26
]
],
"text": [
"retention of urine"
],
"type": "Disease"
},
{
"id": "2759",
"normalized": [
{
"db_... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"fentanyl",
"fentanyl",
"fentanyl",
"fentanyl",
"fentanyl",
"fentanyl",
"fentanyl",
"fentanyl"
] | [
"respiratory depression",
"hypotension",
"urinary bladder retention",
"bradycardia",
"retention of urine",
"chest wall rigidity",
"hydronephrosis",
"pain"
] | [
{
"id": "2764",
"normalized": [
{
"db_id": "D012131",
"db_name": "MESH"
}
],
"offsets": [
[
565,
587
]
],
"text": [
"respiratory depression"
],
"type": "Disease"
},
{
"id": "2763",
"normalized": [
{
... | [
{
"id": "2758",
"normalized": [
{
"db_id": "D005283",
"db_name": "MESH"
}
],
"offsets": [
[
77,
85
]
],
"text": [
"fentanyl"
],
"type": "Chemical"
},
{
"id": "2758",
"normalized": [
{
"db_id": "D0... | [
true,
true,
true,
true,
true,
true,
true,
false
] |
Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice. | Highly active antiretroviral therapy (HAART) is implicated in cardiomyopathy (CM) and in elevated plasma lactate (LA) in AIDS through mechanisms of mitochondrial dysfunction. To determine mitochondrial events from HAART in vivo, 8-week-old hemizygous transgenic AIDS mice (NL4-3Delta gag/pol; TG) and wild-type FVB/n lit... | [
{
"id": "2793",
"normalized": [
{
"db_id": "D019344",
"db_name": "MESH"
}
],
"offsets": [
[
74,
81
]
],
"text": [
"lactate"
],
"type": "Chemical"
},
{
"id": "2797",
"normalized": [
{
"db_id": "D01... | [
{
"id": "2792",
"normalized": [
{
"db_id": "D009202",
"db_name": "MESH"
}
],
"offsets": [
[
39,
53
]
],
"text": [
"cardiomyopathy"
],
"type": "Disease"
},
{
"id": "2794",
"normalized": [
{
"db_id"... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"indinavir",
"lamivudine",
"zidovudine",
"lactate",
"lactate",
"calcium"
] | [
"cardiomyopathy",
"cardiomyopathy",
"cardiomyopathy",
"cardiomyopathy",
"AIDS",
"cardiomyopathy"
] | [
{
"id": "2792",
"normalized": [
{
"db_id": "D009202",
"db_name": "MESH"
}
],
"offsets": [
[
39,
53
]
],
"text": [
"cardiomyopathy"
],
"type": "Disease"
},
{
"id": "2792",
"normalized": [
{
"db_id"... | [
{
"id": "2804",
"normalized": [
{
"db_id": "D019469",
"db_name": "MESH"
}
],
"offsets": [
[
507,
516
]
],
"text": [
"indinavir"
],
"type": "Chemical"
},
{
"id": "2803",
"normalized": [
{
"db_id": ... | [
false,
false,
false,
true,
true,
true
] |
Oral contraceptives and the risk of myocardial infarction. | BACKGROUND: An association between the use of oral contraceptives and the risk of myocardial infarction has been found in some, but not all, studies. We investigated this association, according to the type of progestagen included in third-generation (i.e., desogestrel or gestodene) and second-generation (i.e., levonorg... | [
{
"id": "2830",
"normalized": [
{
"db_id": "D003276",
"db_name": "MESH"
}
],
"offsets": [
[
0,
19
]
],
"text": [
"Oral contraceptives"
],
"type": "Chemical"
},
{
"id": "2832",
"normalized": [
{
"d... | [
{
"id": "2831",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
36,
57
]
],
"text": [
"myocardial infarction"
],
"type": "Disease"
},
{
"id": "2833",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"Oral contraceptives",
"gestodene"
] | [
"myocardial infarction",
"myocardial infarction"
] | [
{
"id": "2831",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
36,
57
]
],
"text": [
"myocardial infarction"
],
"type": "Disease"
},
{
"id": "2831",
"normalized": [
{
... | [
{
"id": "2830",
"normalized": [
{
"db_id": "D003276",
"db_name": "MESH"
}
],
"offsets": [
[
0,
19
]
],
"text": [
"Oral contraceptives"
],
"type": "Chemical"
},
{
"id": "2836",
"normalized": [
{
"d... | [
true,
true
] |
Effects of 5-HT1B receptor ligands microinjected into the accumbal shell or core on the cocaine-induced locomotor hyperactivity in rats. | The present study was designed to examine the effect of 5-HT1B receptor ligands microinjected into the subregions of the nucleus accumbens (the shell and the core) on the locomotor hyperactivity induced by cocaine in rats. Male Wistar rats were implanted bilaterally with cannulae into the accumbens shell or core, and t... | [
{
"id": "2941",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
88,
95
]
],
"text": [
"cocaine"
],
"type": "Chemical"
},
{
"id": "2944",
"normalized": [
{
"db_id": "D00... | [
{
"id": "2942",
"normalized": [
{
"db_id": "D009069",
"db_name": "MESH"
}
],
"offsets": [
[
104,
127
]
],
"text": [
"locomotor hyperactivity"
],
"type": "Disease"
},
{
"id": "2943",
"normalized": [
{
... | [
"Yes",
"Yes",
"No"
] | [
"cocaine",
"CP 93129",
"GR 55562"
] | [
"locomotor hyperactivity",
"locomotor hyperactivity",
"locomotor hyperactivity"
] | [
{
"id": "2942",
"normalized": [
{
"db_id": "D009069",
"db_name": "MESH"
}
],
"offsets": [
[
104,
127
]
],
"text": [
"locomotor hyperactivity"
],
"type": "Disease"
},
{
"id": "2942",
"normalized": [
{
... | [
{
"id": "2941",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
88,
95
]
],
"text": [
"cocaine"
],
"type": "Chemical"
},
{
"id": "2946",
"normalized": [
{
"db_id": "C06... | [
true,
true,
true
] |
Ticlopidine-induced cholestatic hepatitis. | OBJECTIVE: To report 2 cases of ticlopidine-induced cholestatic hepatitis, investigate its mechanism, and compare the observed main characteristics with those of the published cases. CASE SUMMARIES: Two patients developed prolonged cholestatic hepatitis after receiving ticlopidine following percutaneous coronary angiop... | [
{
"id": "3009",
"normalized": [
{
"db_id": "D013988",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Ticlopidine"
],
"type": "Chemical"
},
{
"id": "3013",
"normalized": [
{
"db_id": "... | [
{
"id": "3010",
"normalized": [
{
"db_id": "D002779",
"db_name": "MESH"
},
{
"db_id": "D056486",
"db_name": "MESH"
}
],
"offsets": [
[
20,
41
]
],
"text": [
"cholestatic hepatitis"
],
"type": "D... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No"
] | [
"Ticlopidine",
"Ticlopidine",
"Ticlopidine",
"Ticlopidine",
"clopidogrel",
"clopidogrel",
"clopidogrel",
"clopidogrel"
] | [
"jaundice",
"cholestatic hepatitis",
"cholestatic",
"hepatitis",
"hepatitis",
"cholestatic",
"cholestatic hepatitis",
"jaundice"
] | [
{
"id": "3026",
"normalized": [
{
"db_id": "D007565",
"db_name": "MESH"
}
],
"offsets": [
[
745,
753
]
],
"text": [
"jaundice"
],
"type": "Disease"
},
{
"id": "3010",
"normalized": [
{
"db_id": "D... | [
{
"id": "3009",
"normalized": [
{
"db_id": "D013988",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Ticlopidine"
],
"type": "Chemical"
},
{
"id": "3009",
"normalized": [
{
"db_id": "... | [
true,
true,
true,
true,
false,
false,
false,
false
] |
Epithelial sodium channel (ENaC) subunit mRNA and protein expression in rats with puromycin aminonucleoside-induced nephrotic syndrome. | In experimental nephrotic syndrome, urinary sodium excretion is decreased during the early phase of the disease. The molecular mechanism(s) leading to salt retention has not been completely elucidated. The rate-limiting constituent of collecting duct sodium transport is the epithelial sodium channel (ENaC). We examined... | [
{
"id": "3325",
"normalized": [
{
"db_id": "D012964",
"db_name": "MESH"
}
],
"offsets": [
[
11,
17
]
],
"text": [
"sodium"
],
"type": "Chemical"
},
{
"id": "3326",
"normalized": [
{
"db_id": "D011... | [
{
"id": "3327",
"normalized": [
{
"db_id": "D009404",
"db_name": "MESH"
}
],
"offsets": [
[
116,
134
]
],
"text": [
"nephrotic syndrome"
],
"type": "Disease"
},
{
"id": "3328",
"normalized": [
{
"... | [
"Yes",
"Yes",
"No",
"No"
] | [
"puromycin aminonucleoside",
"puromycin aminonucleoside",
"aldosterone",
"sodium"
] | [
"proteinuria",
"nephrotic syndrome",
"proteinuria",
"nephrotic syndrome"
] | [
{
"id": "3337",
"normalized": [
{
"db_id": "D011507",
"db_name": "MESH"
}
],
"offsets": [
[
652,
663
]
],
"text": [
"proteinuria"
],
"type": "Disease"
},
{
"id": "3327",
"normalized": [
{
"db_id":... | [
{
"id": "3326",
"normalized": [
{
"db_id": "D011692",
"db_name": "MESH"
}
],
"offsets": [
[
82,
107
]
],
"text": [
"puromycin aminonucleoside"
],
"type": "Chemical"
},
{
"id": "3326",
"normalized": [
{
... | [
true,
true,
true,
true
] |
NO-induced migraine attack: strong increase in plasma calcitonin gene-related peptide (CGRP) concentration and negative correlation with platelet serotonin release. | The aim of the present study was to investigate changes in the plasma calcitonin gene-related peptide (CGRP) concentration and platelet serotonin (5-hydroxytriptamine, 5-HT) content during the immediate headache and the delayed genuine migraine attack provoked by nitroglycerin. Fifteen female migraineurs (without aura)... | [
{
"id": "3396",
"normalized": [
{
"db_id": "D009569",
"db_name": "MESH"
}
],
"offsets": [
[
0,
2
]
],
"text": [
"NO"
],
"type": "Chemical"
},
{
"id": "3398",
"normalized": [
{
"db_id": "D015740",
... | [
{
"id": "3397",
"normalized": [
{
"db_id": "D008881",
"db_name": "MESH"
}
],
"offsets": [
[
11,
19
]
],
"text": [
"migraine"
],
"type": "Disease"
},
{
"id": "3406",
"normalized": [
{
"db_id": "D00... | [
"Yes",
"Yes",
"No",
"No"
] | [
"nitroglycerin",
"NO",
"calcitonin gene-related peptide",
"calcitonin gene-related peptide"
] | [
"migraineurs (without aura)",
"migraineurs (without aura)",
"migraineurs (without aura)",
"headache"
] | [
{
"id": "3409",
"normalized": [
{
"db_id": "D020326",
"db_name": "MESH"
}
],
"offsets": [
[
459,
485
]
],
"text": [
"migraineurs (without aura)"
],
"type": "Disease"
},
{
"id": "3409",
"normalized": [
{
... | [
{
"id": "3408",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
429,
442
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "3396",
"normalized": [
{
"db_i... | [
false,
false,
false,
true
] |
Coronary aneurysm after implantation of a paclitaxel-eluting stent. | Formation of coronary aneurysm is a rare complication of stenting with bare metal stents, but based on experimental studies drug-eluting stents may induce toxic effects on the vessel wall with incomplete stent apposition, aneurysm formation and with the potential of stent thrombosis or vessel rupture. We present a 43-y... | [
{
"id": "3447",
"normalized": [
{
"db_id": "D017239",
"db_name": "MESH"
}
],
"offsets": [
[
42,
52
]
],
"text": [
"paclitaxel"
],
"type": "Chemical"
},
{
"id": "3453",
"normalized": [
{
"db_id": "... | [
{
"id": "3446",
"normalized": [
{
"db_id": "D003323",
"db_name": "MESH"
}
],
"offsets": [
[
0,
17
]
],
"text": [
"Coronary aneurysm"
],
"type": "Disease"
},
{
"id": "3448",
"normalized": [
{
"db_i... | [
"Yes",
"No"
] | [
"paclitaxel",
"paclitaxel"
] | [
"Coronary aneurysm",
"aneurysm"
] | [
{
"id": "3446",
"normalized": [
{
"db_id": "D003323",
"db_name": "MESH"
}
],
"offsets": [
[
0,
17
]
],
"text": [
"Coronary aneurysm"
],
"type": "Disease"
},
{
"id": "3449",
"normalized": [
{
"db_i... | [
{
"id": "3447",
"normalized": [
{
"db_id": "D017239",
"db_name": "MESH"
}
],
"offsets": [
[
42,
52
]
],
"text": [
"paclitaxel"
],
"type": "Chemical"
},
{
"id": "3447",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Behavioral effects of urotensin-II centrally administered in mice. | Urotensin-II (U-II) receptors are widely distributed in the central nervous system. Intracerebroventricular (i.c.v.) injection of U-II causes hypertension and bradycardia and stimulates prolactin and thyrotropin secretion. However, the behavioral effects of centrally administered U-II have received little attention. In... | [
{
"id": "3465",
"normalized": [
{
"db_id": "D014579",
"db_name": "MESH"
}
],
"offsets": [
[
22,
34
]
],
"text": [
"urotensin-II"
],
"type": "Chemical"
},
{
"id": "3466",
"normalized": [
{
"db_id":... | [
{
"id": "3469",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
209,
221
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "3470",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"apomorphine",
"corticosterone"
] | [
"penile erection",
"bradycardia"
] | [
{
"id": "3477",
"normalized": [
{
"db_id": "D010409",
"db_name": "MESH"
}
],
"offsets": [
[
1349,
1364
]
],
"text": [
"penile erection"
],
"type": "Disease"
},
{
"id": "3470",
"normalized": [
{
"d... | [
{
"id": "3476",
"normalized": [
{
"db_id": "D001058",
"db_name": "MESH"
}
],
"offsets": [
[
1329,
1340
]
],
"text": [
"apomorphine"
],
"type": "Chemical"
},
{
"id": "3478",
"normalized": [
{
"db_i... | [
true,
false
] |
Recurrent dysphonia and acitretin. | We report the case of a woman complaining of dysphonia while she was treated by acitretin. Her symptoms totally regressed after drug withdrawal and reappeared when acitretin was reintroduced. To our knowledge, this is the first case of acitretin-induced dysphonia. This effect may be related to the pharmacological effec... | [
{
"id": "3487",
"normalized": [
{
"db_id": "D017255",
"db_name": "MESH"
}
],
"offsets": [
[
24,
33
]
],
"text": [
"acitretin"
],
"type": "Chemical"
},
{
"id": "3489",
"normalized": [
{
"db_id": "D... | [
{
"id": "3486",
"normalized": [
{
"db_id": "D055154",
"db_name": "MESH"
}
],
"offsets": [
[
10,
19
]
],
"text": [
"dysphonia"
],
"type": "Disease"
},
{
"id": "3488",
"normalized": [
{
"db_id": "D0... | [
"Yes"
] | [
"acitretin"
] | [
"dysphonia"
] | [
{
"id": "3486",
"normalized": [
{
"db_id": "D055154",
"db_name": "MESH"
}
],
"offsets": [
[
10,
19
]
],
"text": [
"dysphonia"
],
"type": "Disease"
}
] | [
{
"id": "3487",
"normalized": [
{
"db_id": "D017255",
"db_name": "MESH"
}
],
"offsets": [
[
24,
33
]
],
"text": [
"acitretin"
],
"type": "Chemical"
}
] | [
true
] |
Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. | Abnormal processing of somatosensory inputs in the central nervous system (central sensitization) is the mechanism accounting for the enhanced pain sensitivity in the skin surrounding tissue injury (secondary hyperalgesia). Secondary hyperalgesia shares clinical characteristics with neurogenic hyperalgesia in patients ... | [
{
"id": "3516",
"normalized": [
{
"db_id": "C040029",
"db_name": "MESH"
}
],
"offsets": [
[
679,
689
]
],
"text": [
"gabapentin"
],
"type": "Chemical"
},
{
"id": "3518",
"normalized": [
{
"db_id":... | [
{
"id": "3508",
"normalized": [
{
"db_id": "D010146",
"db_name": "MESH"
}
],
"offsets": [
[
30,
34
]
],
"text": [
"pain"
],
"type": "Disease"
},
{
"id": "3509",
"normalized": [
{
"db_id": "D010146... | [
"Yes",
"No"
] | [
"capsaicin",
"gabapentin"
] | [
"secondary hyperalgesia",
"neuropathic pain"
] | [
{
"id": "3511",
"normalized": [
{
"db_id": "D006930",
"db_name": "MESH"
}
],
"offsets": [
[
315,
337
]
],
"text": [
"secondary hyperalgesia"
],
"type": "Disease"
},
{
"id": "3514",
"normalized": [
{
... | [
{
"id": "3519",
"normalized": [
{
"db_id": "D002211",
"db_name": "MESH"
}
],
"offsets": [
[
1034,
1043
]
],
"text": [
"capsaicin"
],
"type": "Chemical"
},
{
"id": "3516",
"normalized": [
{
"db_id"... | [
true,
true
] |
MDMA polydrug users show process-specific central executive impairments coupled with impaired social and emotional judgement processes. | In recent years working memory deficits have been reported in users of MDMA (3,4-methylenedioxymethamphetamine, ecstasy). The current study aimed to assess the impact of MDMA use on three separate central executive processes (set shifting, inhibition and memory updating) and also on "prefrontal" mediated social and emo... | [
{
"id": "3535",
"normalized": [
{
"db_id": "D018817",
"db_name": "MESH"
}
],
"offsets": [
[
0,
4
]
],
"text": [
"MDMA"
],
"type": "Chemical"
},
{
"id": "3538",
"normalized": [
{
"db_id": "D018817"... | [
{
"id": "3536",
"normalized": [
{
"db_id": "D003072",
"db_name": "MESH"
}
],
"offsets": [
[
85,
134
]
],
"text": [
"impaired social and emotional judgement processes"
],
"type": "Disease"
},
{
"id": "3537",
"no... | [
"Yes",
"No"
] | [
"MDMA",
"MDMA"
] | [
"impaired social and emotional judgement processes",
"memory deficits"
] | [
{
"id": "3536",
"normalized": [
{
"db_id": "D003072",
"db_name": "MESH"
}
],
"offsets": [
[
85,
134
]
],
"text": [
"impaired social and emotional judgement processes"
],
"type": "Disease"
},
{
"id": "3537",
"no... | [
{
"id": "3535",
"normalized": [
{
"db_id": "D018817",
"db_name": "MESH"
}
],
"offsets": [
[
0,
4
]
],
"text": [
"MDMA"
],
"type": "Chemical"
},
{
"id": "3535",
"normalized": [
{
"db_id": "D018817"... | [
true,
true
] |
Severe citrate toxicity complicating volunteer apheresis platelet donation. | We report a case of severe citrate toxicity during volunteer donor apheresis platelet collection. The donor was a 40-year-old female, first-time apheresis platelet donor. Past medical history was remarkable for hypertension, hyperlipidemia, and depression. Reported medications included bumetanide, pravastatin, and paro... | [
{
"id": "3560",
"normalized": [
{
"db_id": "C102006",
"db_name": "MESH"
}
],
"offsets": [
[
7,
14
]
],
"text": [
"citrate"
],
"type": "Chemical"
},
{
"id": "3562",
"normalized": [
{
"db_id": "C102... | [
{
"id": "3561",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
15,
23
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "3563",
"normalized": [
{
"db_id": "D06... | [
"Yes",
"No"
] | [
"citrate",
"calcium"
] | [
"hypocalcemia",
"muscle contractions"
] | [
{
"id": "3575",
"normalized": [
{
"db_id": "D006996",
"db_name": "MESH"
}
],
"offsets": [
[
878,
890
]
],
"text": [
"hypocalcemia"
],
"type": "Disease"
},
{
"id": "3572",
"normalized": [
{
"db_id"... | [
{
"id": "3560",
"normalized": [
{
"db_id": "C102006",
"db_name": "MESH"
}
],
"offsets": [
[
7,
14
]
],
"text": [
"citrate"
],
"type": "Chemical"
},
{
"id": "3573",
"normalized": [
{
"db_id": "D002... | [
true,
false
] |
Proteinuria after conversion to sirolimus in renal transplant recipients. | Sirolimus (SRL) is a new, potent immunosuppressive agent. More recently, proteinuria has been reported as a consequence of sirolimus therapy, although the mechanism has remained unclear. We retrospectively examined the records of 25 renal transplant patients, who developed or displayed increased proteinuria after SRL c... | [
{
"id": "3599",
"normalized": [
{
"db_id": "D020123",
"db_name": "MESH"
}
],
"offsets": [
[
32,
41
]
],
"text": [
"sirolimus"
],
"type": "Chemical"
},
{
"id": "3600",
"normalized": [
{
"db_id": "D... | [
{
"id": "3598",
"normalized": [
{
"db_id": "D011507",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Proteinuria"
],
"type": "Disease"
},
{
"id": "3602",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"sirolimus",
"sirolimus"
] | [
"Proteinuria",
"nephrotic"
] | [
{
"id": "3598",
"normalized": [
{
"db_id": "D011507",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Proteinuria"
],
"type": "Disease"
},
{
"id": "3622",
"normalized": [
{
"db_id": "D... | [
{
"id": "3599",
"normalized": [
{
"db_id": "D020123",
"db_name": "MESH"
}
],
"offsets": [
[
32,
41
]
],
"text": [
"sirolimus"
],
"type": "Chemical"
},
{
"id": "3599",
"normalized": [
{
"db_id": "D... | [
true,
false
] |
In vitro characterization of parasympathetic and sympathetic responses in cyclophosphamide-induced cystitis in the rat. | In cyclophosphamide-induced cystitis in the rat, detrusor function is impaired and the expression and effects of muscarinic receptors altered. Whether or not the neuronal transmission may be affected by cystitis was presently investigated. Responses of urinary strip preparations from control and cyclophosphamide-pretre... | [
{
"id": "3748",
"normalized": [
{
"db_id": "D003520",
"db_name": "MESH"
}
],
"offsets": [
[
74,
90
]
],
"text": [
"cyclophosphamide"
],
"type": "Chemical"
},
{
"id": "3750",
"normalized": [
{
"db_... | [
{
"id": "3749",
"normalized": [
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
99,
107
]
],
"text": [
"cystitis"
],
"type": "Disease"
},
{
"id": "3751",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"cyclophosphamide",
"atropine"
] | [
"cystitis",
"cystitis"
] | [
{
"id": "3749",
"normalized": [
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
99,
107
]
],
"text": [
"cystitis"
],
"type": "Disease"
},
{
"id": "3749",
"normalized": [
{
"db_id": "D0... | [
{
"id": "3748",
"normalized": [
{
"db_id": "D003520",
"db_name": "MESH"
}
],
"offsets": [
[
74,
90
]
],
"text": [
"cyclophosphamide"
],
"type": "Chemical"
},
{
"id": "3754",
"normalized": [
{
"db_... | [
true,
false
] |
Associations between use of benzodiazepines or related drugs and health, physical abilities and cognitive function: a non-randomised clinical study in the elderly. | OBJECTIVE: To describe associations between the use of benzodiazepines or related drugs (BZDs/RDs) and health, functional abilities and cognitive function in the elderly. METHODS: A non-randomised clinical study of patients aged > or =65 years admitted to acute hospital wards during 1 month. 164 patients (mean age +/- ... | [
{
"id": "3788",
"normalized": [
{
"db_id": "D001569",
"db_name": "MESH"
}
],
"offsets": [
[
28,
43
]
],
"text": [
"benzodiazepines"
],
"type": "Chemical"
},
{
"id": "3789",
"normalized": [
{
"db_i... | [
{
"id": "3797",
"normalized": [
{
"db_id": "D003704",
"db_name": "MESH"
}
],
"offsets": [
[
1568,
1576
]
],
"text": [
"dementia"
],
"type": "Disease"
},
{
"id": "3800",
"normalized": [
{
"db_id": ... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No"
] | [
"benzodiazepines",
"benzodiazepines",
"benzodiazepines",
"benzodiazepines",
"oxazepam",
"temazepam",
"temazepam",
"zopiclone"
] | [
"tiredness",
"depressive symptoms",
"inability to sleep",
"dizziness",
"dementia",
"inability to sleep",
"dizziness",
"depressive symptoms"
] | [
{
"id": "3802",
"normalized": [
{
"db_id": "D005221",
"db_name": "MESH"
}
],
"offsets": [
[
1817,
1826
]
],
"text": [
"tiredness"
],
"type": "Disease"
},
{
"id": "3803",
"normalized": [
{
"db_id":... | [
{
"id": "3788",
"normalized": [
{
"db_id": "D001569",
"db_name": "MESH"
}
],
"offsets": [
[
28,
43
]
],
"text": [
"benzodiazepines"
],
"type": "Chemical"
},
{
"id": "3788",
"normalized": [
{
"db_i... | [
true,
true,
true,
true,
false,
false,
false,
false
] |
Acute vocal fold palsy after acute disulfiram intoxication. | Acute peripheral neuropathy caused by a disulfiram overdose is very rare and there is no report of it leading to vocal fold palsy. A 49-year-old woman was transferred to our department because of quadriparesis, lancinating pain, sensory loss, and paresthesia of the distal limbs. One month previously, she had taken a si... | [
{
"id": "3846",
"normalized": [
{
"db_id": "D004221",
"db_name": "MESH"
}
],
"offsets": [
[
35,
45
]
],
"text": [
"disulfiram"
],
"type": "Chemical"
},
{
"id": "3848",
"normalized": [
{
"db_id": "... | [
{
"id": "3845",
"normalized": [
{
"db_id": "D014826",
"db_name": "MESH"
}
],
"offsets": [
[
6,
22
]
],
"text": [
"vocal fold palsy"
],
"type": "Disease"
},
{
"id": "3847",
"normalized": [
{
"db_id... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"disulfiram",
"disulfiram",
"disulfiram",
"disulfiram",
"disulfiram",
"disulfiram",
"disulfiram",
"disulfiram",
"ALCOHOL",
"ALCOHOL",
"ALCOHOL",
"ALCOHOL"
] | [
"paresthesia",
"quadriparesis",
"pain",
"peripheral neuropathy",
"ataxia",
"vocal fold palsy",
"overdose",
"polyneuropathy",
"ataxia",
"hoarseness",
"vocal fold palsy",
"palsy"
] | [
{
"id": "3854",
"normalized": [
{
"db_id": "D010292",
"db_name": "MESH"
}
],
"offsets": [
[
307,
318
]
],
"text": [
"paresthesia"
],
"type": "Disease"
},
{
"id": "3851",
"normalized": [
{
"db_id":... | [
{
"id": "3846",
"normalized": [
{
"db_id": "D004221",
"db_name": "MESH"
}
],
"offsets": [
[
35,
45
]
],
"text": [
"disulfiram"
],
"type": "Chemical"
},
{
"id": "3846",
"normalized": [
{
"db_id": "... | [
false,
false,
false,
true,
false,
true,
true,
true,
false,
false,
false,
false
] |
Higher optical density of an antigen assay predicts thrombosis in patients with heparin-induced thrombocytopenia. | OBJECTIVES: To correlate optical density and percent inhibition of a two-step heparin-induced thrombocytopenia (HIT) antigen assay with thrombosis; the assay utilizes reaction inhibition characteristics of a high heparin concentration. PATIENTS AND METHODS: Patients with more than 50% decrease in platelet count or thro... | [
{
"id": "3896",
"normalized": [
{
"db_id": "D006493",
"db_name": "MESH"
}
],
"offsets": [
[
80,
87
]
],
"text": [
"heparin"
],
"type": "Chemical"
},
{
"id": "3898",
"normalized": [
{
"db_id": "D00... | [
{
"id": "3895",
"normalized": [
{
"db_id": "D013927",
"db_name": "MESH"
}
],
"offsets": [
[
52,
62
]
],
"text": [
"thrombosis"
],
"type": "Disease"
},
{
"id": "3897",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes"
] | [
"heparin",
"heparin"
] | [
"thrombosis",
"thrombocytopenia"
] | [
{
"id": "3895",
"normalized": [
{
"db_id": "D013927",
"db_name": "MESH"
}
],
"offsets": [
[
52,
62
]
],
"text": [
"thrombosis"
],
"type": "Disease"
},
{
"id": "3897",
"normalized": [
{
"db_id": "D... | [
{
"id": "3896",
"normalized": [
{
"db_id": "D006493",
"db_name": "MESH"
}
],
"offsets": [
[
80,
87
]
],
"text": [
"heparin"
],
"type": "Chemical"
},
{
"id": "3896",
"normalized": [
{
"db_id": "D00... | [
true,
true
] |
Central retinal vein occlusion associated with clomiphene-induced ovulation. | OBJECTIVE: To report a case of central retinal vein occlusion associated with clomiphene citrate (CC). DESIGN: Case study. SETTING: Ophthalmology clinic of an academic hospital. PATIENT(S): A 36-year-old woman referred from the infertility clinic for blurred vision. INTERVENTION(S): Ophthalmic examination after CC ther... | [
{
"id": "4066",
"normalized": [
{
"db_id": "D002996",
"db_name": "MESH"
}
],
"offsets": [
[
47,
57
]
],
"text": [
"clomiphene"
],
"type": "Chemical"
},
{
"id": "4068",
"normalized": [
{
"db_id": "... | [
{
"id": "4065",
"normalized": [
{
"db_id": "D012170",
"db_name": "MESH"
}
],
"offsets": [
[
8,
30
]
],
"text": [
"retinal vein occlusion"
],
"type": "Disease"
},
{
"id": "4067",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"clomiphene",
"clomiphene",
"clomiphene",
"clomiphene"
] | [
"retinal vein occlusion",
"blurred vision",
"thromboembolic",
"infertility"
] | [
{
"id": "4065",
"normalized": [
{
"db_id": "D012170",
"db_name": "MESH"
}
],
"offsets": [
[
8,
30
]
],
"text": [
"retinal vein occlusion"
],
"type": "Disease"
},
{
"id": "4071",
"normalized": [
{
... | [
{
"id": "4066",
"normalized": [
{
"db_id": "D002996",
"db_name": "MESH"
}
],
"offsets": [
[
47,
57
]
],
"text": [
"clomiphene"
],
"type": "Chemical"
},
{
"id": "4066",
"normalized": [
{
"db_id": "... | [
true,
true,
true,
true
] |
Nicotine-induced nystagmus correlates with midpontine activation. | The pathomechanism of nicotine-induced nystagmus (NIN) is unknown. The aim of this study was to delineate brain structures that are involved in NIN generation. Eight healthy volunteers inhaled nicotine in darkness during a functional magnetic resonance imaging (fMRI) experiment; eye movements were registered using vide... | [
{
"id": "4158",
"normalized": [
{
"db_id": "D009538",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Nicotine"
],
"type": "Chemical"
},
{
"id": "4160",
"normalized": [
{
"db_id": "D009... | [
{
"id": "4159",
"normalized": [
{
"db_id": "D009759",
"db_name": "MESH"
}
],
"offsets": [
[
17,
26
]
],
"text": [
"nystagmus"
],
"type": "Disease"
},
{
"id": "4161",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"Nicotine",
"oxygen"
] | [
"nystagmus",
"nystagmus"
] | [
{
"id": "4159",
"normalized": [
{
"db_id": "D009759",
"db_name": "MESH"
}
],
"offsets": [
[
17,
26
]
],
"text": [
"nystagmus"
],
"type": "Disease"
},
{
"id": "4159",
"normalized": [
{
"db_id": "D0... | [
{
"id": "4158",
"normalized": [
{
"db_id": "D009538",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Nicotine"
],
"type": "Chemical"
},
{
"id": "4166",
"normalized": [
{
"db_id": "D010... | [
true,
true
] |
Protective effect of verapamil on gastric hemorrhagic ulcers in severe atherosclerotic rats. | Studies concerning with pathogenesis of gastric hemorrhage and mucosal ulceration produced in atherosclerotic rats are lacking. The aim of this study is to examine the role of gastric acid back-diffusion, mast cell histamine release, lipid peroxide (LPO) generation and mucosal microvascular permeability in modulating g... | [
{
"id": "4189",
"normalized": [
{
"db_id": "D014700",
"db_name": "MESH"
}
],
"offsets": [
[
21,
30
]
],
"text": [
"verapamil"
],
"type": "Chemical"
},
{
"id": "4195",
"normalized": [
{
"db_id": "D... | [
{
"id": "4190",
"normalized": [
{
"db_id": "D006471",
"db_name": "MESH"
}
],
"offsets": [
[
34,
53
]
],
"text": [
"gastric hemorrhagic"
],
"type": "Disease"
},
{
"id": "4191",
"normalized": [
{
"d... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"vitamin D2",
"vitamin D2",
"cholesterol",
"cholesterol",
"cholesterol",
"vitamin D2",
"verapamil",
"histamine",
"histamine",
"luminal",
"calcium",
"histamine"
] | [
"gastric hemorrhagic",
"atherosclerotic",
"gastric hemorrhagic",
"ulcers",
"atherosclerotic",
"ulcers",
"gastric hemorrhagic",
"ulcers",
"atherosclerotic",
"ulcers",
"atherosclerotic",
"gastric hemorrhagic"
] | [
{
"id": "4190",
"normalized": [
{
"db_id": "D006471",
"db_name": "MESH"
}
],
"offsets": [
[
34,
53
]
],
"text": [
"gastric hemorrhagic"
],
"type": "Disease"
},
{
"id": "4192",
"normalized": [
{
"d... | [
{
"id": "4199",
"normalized": [
{
"db_id": "D004872",
"db_name": "MESH"
}
],
"offsets": [
[
501,
511
]
],
"text": [
"vitamin D2"
],
"type": "Chemical"
},
{
"id": "4199",
"normalized": [
{
"db_id":... | [
true,
true,
true,
true,
true,
true,
true,
true,
true,
true,
true,
true
] |
Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure. | BACKGROUND: The mechanisms underlying heart failure induced by adriamycin are very complicated and still unclear. The aim of this study was to investigate whether autophagy was involved in the progression of heart failure induced by adriamycin, so that we can develop a novel treatment strategy for heart failure. METHOD... | [
{
"id": "4341",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Adriamycin"
],
"type": "Chemical"
},
{
"id": "4345",
"normalized": [
{
"db_id": "D... | [
{
"id": "4342",
"normalized": [
{
"db_id": "D003643",
"db_name": "MESH"
}
],
"offsets": [
[
44,
49
]
],
"text": [
"death"
],
"type": "Disease"
},
{
"id": "4343",
"normalized": [
{
"db_id": "D00633... | [
"Yes",
"No"
] | [
"Adriamycin",
"3-methyladenine"
] | [
"heart failure",
"heart failure"
] | [
{
"id": "4343",
"normalized": [
{
"db_id": "D006333",
"db_name": "MESH"
}
],
"offsets": [
[
92,
105
]
],
"text": [
"heart failure"
],
"type": "Disease"
},
{
"id": "4343",
"normalized": [
{
"db_id"... | [
{
"id": "4341",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Adriamycin"
],
"type": "Chemical"
},
{
"id": "4349",
"normalized": [
{
"db_id": "C... | [
true,
true
] |
Confusion, a rather serious adverse drug reaction with valproic acid: a review of the French Pharmacovigilance database. | INTRODUCTION: Confusion is an adverse drug reaction frequently observed with valproic acid. Some case reports are published in the literature but no systematic study from a sample of patients has been published. We performed this study in order to describe the main characteristics of this adverse drug reaction. METHODS... | [
{
"id": "4440",
"normalized": [
{
"db_id": "D014635",
"db_name": "MESH"
}
],
"offsets": [
[
55,
68
]
],
"text": [
"valproic acid"
],
"type": "Chemical"
},
{
"id": "4442",
"normalized": [
{
"db_id"... | [
{
"id": "4439",
"normalized": [
{
"db_id": "D003221",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Confusion"
],
"type": "Disease"
},
{
"id": "4441",
"normalized": [
{
"db_id": "D003... | [
"Yes"
] | [
"valproic acid"
] | [
"Confusion"
] | [
{
"id": "4439",
"normalized": [
{
"db_id": "D003221",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Confusion"
],
"type": "Disease"
}
] | [
{
"id": "4440",
"normalized": [
{
"db_id": "D014635",
"db_name": "MESH"
}
],
"offsets": [
[
55,
68
]
],
"text": [
"valproic acid"
],
"type": "Chemical"
}
] | [
true
] |
Learning and memory deficits in ecstasy users and their neural correlates during a face-learning task. | It has been consistently shown that ecstasy users display impairments in learning and memory performance. In addition, working memory processing in ecstasy users has been shown to be associated with neural alterations in hippocampal and/or cortical regions as measured by functional magnetic resonance imaging (fMRI). Us... | [
{
"id": "4493",
"normalized": [
{
"db_id": "D018817",
"db_name": "MESH"
}
],
"offsets": [
[
32,
39
]
],
"text": [
"ecstasy"
],
"type": "Chemical"
},
{
"id": "4494",
"normalized": [
{
"db_id": "D01... | [
{
"id": "4490",
"normalized": [
{
"db_id": "D007859",
"db_name": "MESH"
},
{
"db_id": "D008569",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
]
],
"text": [
"Learning and memory deficits"
],
"typ... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"ecstasy",
"ecstasy",
"ecstasy",
"cannabis",
"cannabis",
"ecstasy"
] | [
"Learning and memory deficits",
"memory deficits",
"Learning",
"hyperactivity",
"memory deficits",
"hyperactivity"
] | [
{
"id": "4490",
"normalized": [
{
"db_id": "D007859",
"db_name": "MESH"
},
{
"db_id": "D008569",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
]
],
"text": [
"Learning and memory deficits"
],
"typ... | [
{
"id": "4493",
"normalized": [
{
"db_id": "D018817",
"db_name": "MESH"
}
],
"offsets": [
[
32,
39
]
],
"text": [
"ecstasy"
],
"type": "Chemical"
},
{
"id": "4493",
"normalized": [
{
"db_id": "D01... | [
true,
true,
true,
true,
true,
true
] |
Prolonged elevation of plasma argatroban in a cardiac transplant patient with a suspected history of heparin-induced thrombocytopenia with thrombosis. | BACKGROUND: Direct thrombin inhibitors (DTIs) provide an alternative method of anticoagulation for patients with a history of heparin-induced thrombocytopenia (HIT) or HIT with thrombosis (HITT) undergoing cardiopulmonary bypass (CPB). In the following report, a 65-year-old critically ill patient with a suspected histo... | [
{
"id": "4667",
"normalized": [
{
"db_id": "C031942",
"db_name": "MESH"
}
],
"offsets": [
[
30,
40
]
],
"text": [
"argatroban"
],
"type": "Chemical"
},
{
"id": "4668",
"normalized": [
{
"db_id": "... | [
{
"id": "4669",
"normalized": [
{
"db_id": "D013921",
"db_name": "MESH"
}
],
"offsets": [
[
117,
133
]
],
"text": [
"thrombocytopenia"
],
"type": "Disease"
},
{
"id": "4670",
"normalized": [
{
"db... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"argatroban",
"argatroban",
"argatroban",
"heparin",
"argatroban",
"argatroban"
] | [
"intraoperative and postoperative bleeding",
"intraoperative",
"postoperative bleeding",
"hepatic impairment",
"thrombocytopenia",
"coagulopathy"
] | [
{
"id": "4680",
"normalized": [
{
"db_id": "D016063",
"db_name": "MESH"
},
{
"db_id": "D019106",
"db_name": "MESH"
}
],
"offsets": [
[
789,
830
]
],
"text": [
"intraoperative and postoperative bleeding"... | [
{
"id": "4667",
"normalized": [
{
"db_id": "C031942",
"db_name": "MESH"
}
],
"offsets": [
[
30,
40
]
],
"text": [
"argatroban"
],
"type": "Chemical"
},
{
"id": "4667",
"normalized": [
{
"db_id": "... | [
false,
false,
false,
false,
true,
true
] |
Antituberculosis therapy-induced acute liver failure: magnitude, profile, prognosis, and predictors of outcome. | Antituberculosis therapy (ATT)-associated acute liver failure (ATT-ALF) is the commonest drug-induced ALF in South Asia. Prospective studies on ATT-ALF are lacking. The current study prospectively evaluated the magnitude, clinical course, outcome, and prognostic factors in ATT-ALF. From January 1986 to January 2009, 12... | [
{
"id": "4727",
"normalized": [
{
"db_id": "D000995",
"db_name": "MESH"
}
],
"offsets": [
[
0,
16
]
],
"text": [
"Antituberculosis"
],
"type": "Chemical"
},
{
"id": "4729",
"normalized": [
{
"db_i... | [
{
"id": "4728",
"normalized": [
{
"db_id": "D017114",
"db_name": "MESH"
}
],
"offsets": [
[
33,
52
]
],
"text": [
"acute liver failure"
],
"type": "Disease"
},
{
"id": "4730",
"normalized": [
{
"d... | [
"Yes",
"No"
] | [
"Antituberculosis",
"bilirubin"
] | [
"acute liver failure",
"acute renal failure"
] | [
{
"id": "4728",
"normalized": [
{
"db_id": "D017114",
"db_name": "MESH"
}
],
"offsets": [
[
33,
52
]
],
"text": [
"acute liver failure"
],
"type": "Disease"
},
{
"id": "4747",
"normalized": [
{
"d... | [
{
"id": "4727",
"normalized": [
{
"db_id": "D000995",
"db_name": "MESH"
}
],
"offsets": [
[
0,
16
]
],
"text": [
"Antituberculosis"
],
"type": "Chemical"
},
{
"id": "4752",
"normalized": [
{
"db_i... | [
true,
false
] |
Central nervous system complications during treatment of acute lymphoblastic leukemia in a single pediatric institution. | Central nervous system (CNS) complications during treatment of childhood acute lymphoblastic leukemia (ALL) remain a challenging clinical problem. Outcome improvement with more intensive chemotherapy has significantly increased the incidence and severity of adverse events. This study analyzed the incidence of neurologi... | [
{
"id": "4802",
"normalized": [
{
"db_id": "D008727",
"db_name": "MESH"
}
],
"offsets": [
[
1064,
1076
]
],
"text": [
"methotrexate"
],
"type": "Chemical"
}
] | [
{
"id": "4787",
"normalized": [
{
"db_id": "D002493",
"db_name": "MESH"
}
],
"offsets": [
[
0,
36
]
],
"text": [
"Central nervous system complications"
],
"type": "Disease"
},
{
"id": "4788",
"normalized": [
... | [
"Yes",
"No"
] | [
"methotrexate",
"methotrexate"
] | [
"Central nervous system complications",
"acute lymphoblastic leukemia"
] | [
{
"id": "4787",
"normalized": [
{
"db_id": "D002493",
"db_name": "MESH"
}
],
"offsets": [
[
0,
36
]
],
"text": [
"Central nervous system complications"
],
"type": "Disease"
},
{
"id": "4788",
"normalized": [
... | [
{
"id": "4802",
"normalized": [
{
"db_id": "D008727",
"db_name": "MESH"
}
],
"offsets": [
[
1064,
1076
]
],
"text": [
"methotrexate"
],
"type": "Chemical"
},
{
"id": "4802",
"normalized": [
{
"db_... | [
false,
false
] |
Safety of capecitabine: a review. | IMPORTANCE OF THE FIELD: Fluoropyrimidines, in particular 5-fluorouracil (5-FU), have been the mainstay of treatment for several solid tumors, including colorectal, breast and head and neck cancers, for > 40 years. AREAS COVERED IN THIS REVIEW: This article reviews the pharmacology and efficacy of capecitabine with a s... | [
{
"id": "4813",
"normalized": [
{
"db_id": "C110904",
"db_name": "MESH"
}
],
"offsets": [
[
10,
22
]
],
"text": [
"capecitabine"
],
"type": "Chemical"
},
{
"id": "4815",
"normalized": [
{
"db_id":... | [
{
"id": "4817",
"normalized": [
{
"db_id": "D009369",
"db_name": "MESH"
}
],
"offsets": [
[
169,
175
]
],
"text": [
"tumors"
],
"type": "Disease"
},
{
"id": "4818",
"normalized": [
{
"db_id": "D01... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No"
] | [
"capecitabine",
"capecitabine",
"capecitabine",
"capecitabine",
"capecitabine",
"5-fluorouracil",
"capecitabine",
"5-fluorouracil",
"capecitabine",
"5-fluorouracil"
] | [
"hand-foot syndrome",
"stomatitis",
"vomiting",
"diarrhea",
"nausea",
"pancreaticobiliary",
"colorectal, breast, pancreaticobiliary, gastric, renal cell and head and neck cancers",
"diarrhea",
"colorectal, breast and head and neck cancers",
"vomiting"
] | [
{
"id": "4840",
"normalized": [
{
"db_id": "D060831",
"db_name": "MESH"
}
],
"offsets": [
[
1104,
1122
]
],
"text": [
"hand-foot syndrome"
],
"type": "Disease"
},
{
"id": "4839",
"normalized": [
{
... | [
{
"id": "4813",
"normalized": [
{
"db_id": "C110904",
"db_name": "MESH"
}
],
"offsets": [
[
10,
22
]
],
"text": [
"capecitabine"
],
"type": "Chemical"
},
{
"id": "4813",
"normalized": [
{
"db_id":... | [
true,
true,
true,
true,
true,
false,
false,
false,
false,
false
] |
Effects of pallidal neurotensin on haloperidol-induced parkinsonian catalepsy: behavioral and electrophysiological studies. | OBJECTIVE: The globus pallidus plays a critical role in movement regulation. Previous studies have indicated that the globus pallidus receives neurotensinergic innervation from the striatum, and systemic administration of a neurotensin analog could produce antiparkinsonian effects. The present study aimed to investigat... | [
{
"id": "4883",
"normalized": [
{
"db_id": "D009496",
"db_name": "MESH"
}
],
"offsets": [
[
20,
31
]
],
"text": [
"neurotensin"
],
"type": "Chemical"
},
{
"id": "4884",
"normalized": [
{
"db_id": ... | [
{
"id": "4885",
"normalized": [
{
"db_id": "D002375",
"db_name": "MESH"
}
],
"offsets": [
[
55,
77
]
],
"text": [
"parkinsonian catalepsy"
],
"type": "Disease"
},
{
"id": "4889",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"haloperidol",
"neurotensin type-1 receptor antagonist"
] | [
"parkinsonian catalepsy",
"parkinsonian symptoms"
] | [
{
"id": "4885",
"normalized": [
{
"db_id": "D002375",
"db_name": "MESH"
}
],
"offsets": [
[
55,
77
]
],
"text": [
"parkinsonian catalepsy"
],
"type": "Disease"
},
{
"id": "4889",
"normalized": [
{
... | [
{
"id": "4884",
"normalized": [
{
"db_id": "D006220",
"db_name": "MESH"
}
],
"offsets": [
[
35,
46
]
],
"text": [
"haloperidol"
],
"type": "Chemical"
},
{
"id": "4895",
"normalized": [
{
"db_id": ... | [
true,
false
] |
Antihypertensive drugs and depression: a reappraisal. | Eighty-nine new referral hypertensive out-patients and 46 new referral non-hypertensive chronically physically ill out-patients completed a mood rating scale at regular intervals for one year. The results showed a high prevalence of depression in both groups of patients, with no preponderance in the hypertensive group.... | [
{
"id": "4920",
"normalized": [
{
"db_id": "D008750",
"db_name": "MESH"
}
],
"offsets": [
[
567,
578
]
],
"text": [
"methyl dopa"
],
"type": "Chemical"
}
] | [
{
"id": "4911",
"normalized": [
{
"db_id": "D003866",
"db_name": "MESH"
}
],
"offsets": [
[
27,
37
]
],
"text": [
"depression"
],
"type": "Disease"
},
{
"id": "4912",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"methyl dopa",
"methyl dopa"
] | [
"depression",
"psychiatric"
] | [
{
"id": "4911",
"normalized": [
{
"db_id": "D003866",
"db_name": "MESH"
}
],
"offsets": [
[
27,
37
]
],
"text": [
"depression"
],
"type": "Disease"
},
{
"id": "4917",
"normalized": [
{
"db_id": "D... | [
{
"id": "4920",
"normalized": [
{
"db_id": "D008750",
"db_name": "MESH"
}
],
"offsets": [
[
567,
578
]
],
"text": [
"methyl dopa"
],
"type": "Chemical"
},
{
"id": "4920",
"normalized": [
{
"db_id"... | [
true,
true
] |
Pulmonary shunt and cardiovascular responses to CPAP during nitroprusside-induced hypotension. | The effects of continuous positive airway pressure (CPAP) on cardiovascular dynamics and pulmonary shunt (QS/QT) were investigated in 12 dogs before and during sodium nitroprusside infusion that decreased mean arterial blood pressure 40-50 per cent. Before nitroprusside infusion, 5 cm H2O CPAP significantly, P less tha... | [
{
"id": "4929",
"normalized": [
{
"db_id": "D009599",
"db_name": "MESH"
}
],
"offsets": [
[
60,
73
]
],
"text": [
"nitroprusside"
],
"type": "Chemical"
},
{
"id": "4931",
"normalized": [
{
"db_id"... | [
{
"id": "4930",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
82,
93
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "4936",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"nitroprusside",
"nitroprusside",
"H2O",
"H2O"
] | [
"hypotension",
"decreases in arterial blood pressure and cardiac output",
"hypotension",
"decreased cardiac output"
] | [
{
"id": "4930",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
82,
93
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "4946",
"normalized": [
{
"db_id": "... | [
{
"id": "4929",
"normalized": [
{
"db_id": "D009599",
"db_name": "MESH"
}
],
"offsets": [
[
60,
73
]
],
"text": [
"nitroprusside"
],
"type": "Chemical"
},
{
"id": "4929",
"normalized": [
{
"db_id"... | [
true,
true,
true,
true
] |
Mediation of enhanced reflex vagal bradycardia by L-dopa via central dopamine formation in dogs. | L-Dopa (5 mg/kg i.v.) decreased blood pressure and heart rate after extracerebral decarboxylase inhibition with MK-486 (25 mg/kg i.v.) in anesthetize MAO-inhibited dogs. In addition, reflex bradycardia caused by injected norepinephrine was significantly enhanced by L-dopa, DL-Threo-dihydroxyphenylserine had no effect o... | [
{
"id": "4993",
"normalized": [
{
"db_id": "D007980",
"db_name": "MESH"
}
],
"offsets": [
[
50,
56
]
],
"text": [
"L-dopa"
],
"type": "Chemical"
},
{
"id": "4994",
"normalized": [
{
"db_id": "D004... | [
{
"id": "4992",
"normalized": [
{
"db_id": "D001919",
"db_name": "MESH"
}
],
"offsets": [
[
35,
46
]
],
"text": [
"bradycardia"
],
"type": "Disease"
},
{
"id": "4998",
"normalized": [
{
"db_id": "... | [
"Yes",
"No"
] | [
"norepinephrine",
"norepinephrine"
] | [
"bradycardia",
"hypotension"
] | [
{
"id": "4992",
"normalized": [
{
"db_id": "D001919",
"db_name": "MESH"
}
],
"offsets": [
[
35,
46
]
],
"text": [
"bradycardia"
],
"type": "Disease"
},
{
"id": "5005",
"normalized": [
{
"db_id": "... | [
{
"id": "4999",
"normalized": [
{
"db_id": "D009638",
"db_name": "MESH"
}
],
"offsets": [
[
318,
332
]
],
"text": [
"norepinephrine"
],
"type": "Chemical"
},
{
"id": "4999",
"normalized": [
{
"db_... | [
true,
false
] |
Cocaine-induced myocardial infarction: clinical observations and pathogenetic considerations. | Clinical and experimental data published to date suggest several possible mechanisms by which cocaine may result in acute myocardial infarction. In individuals with preexisting, high-grade coronary arterial narrowing, acute myocardial infarction may result from an increase in myocardial oxygen demand associated with co... | [
{
"id": "5060",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Cocaine"
],
"type": "Chemical"
},
{
"id": "5062",
"normalized": [
{
"db_id": "D0030... | [
{
"id": "5061",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
16,
37
]
],
"text": [
"myocardial infarction"
],
"type": "Disease"
},
{
"id": "5063",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"Cocaine",
"Cocaine"
] | [
"myocardial infarction",
"atherosclerotic obstruction"
] | [
{
"id": "5061",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
16,
37
]
],
"text": [
"myocardial infarction"
],
"type": "Disease"
},
{
"id": "5067",
"normalized": [
{
... | [
{
"id": "5060",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Cocaine"
],
"type": "Chemical"
},
{
"id": "5060",
"normalized": [
{
"db_id": "D0030... | [
true,
false
] |
Rabbit syndrome, antidepressant use, and cerebral perfusion SPECT scan findings. | The rabbit syndrome is an extrapyramidal side effect associated with chronic neuroleptic therapy. Its occurrence in a patient being treated with imipramine is described, representing the first reported case of this syndrome in conjunction with antidepressants. Repeated cerebral perfusion SPECT scans revealed decreased ... | [
{
"id": "5100",
"normalized": [
{
"db_id": "D000928",
"db_name": "MESH"
}
],
"offsets": [
[
17,
31
]
],
"text": [
"antidepressant"
],
"type": "Chemical"
},
{
"id": "5102",
"normalized": [
{
"db_id... | [
{
"id": "5099",
"normalized": [
{
"db_id": "D001480",
"db_name": "MESH"
}
],
"offsets": [
[
0,
15
]
],
"text": [
"Rabbit syndrome"
],
"type": "Disease"
},
{
"id": "5101",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"imipramine",
"antidepressant"
] | [
"Rabbit syndrome",
"movement disorder"
] | [
{
"id": "5099",
"normalized": [
{
"db_id": "D001480",
"db_name": "MESH"
}
],
"offsets": [
[
0,
15
]
],
"text": [
"Rabbit syndrome"
],
"type": "Disease"
},
{
"id": "5105",
"normalized": [
{
"db_id"... | [
{
"id": "5102",
"normalized": [
{
"db_id": "D007099",
"db_name": "MESH"
}
],
"offsets": [
[
226,
236
]
],
"text": [
"imipramine"
],
"type": "Chemical"
},
{
"id": "5100",
"normalized": [
{
"db_id":... | [
false,
false
] |
Acute bronchodilating effects of ipratropium bromide and theophylline in chronic obstructive pulmonary disease. | The bronchodilator effects of a single dose of ipratropium bromide aerosol (36 micrograms) and short-acting theophylline tablets (dose titrated to produce serum levels of 10-20 micrograms/mL) were compared in a double-blind, placebo-controlled crossover study in 21 patients with stable, chronic obstructive pulmonary di... | [
{
"id": "5114",
"normalized": [
{
"db_id": "D009241",
"db_name": "MESH"
}
],
"offsets": [
[
33,
52
]
],
"text": [
"ipratropium bromide"
],
"type": "Chemical"
},
{
"id": "5115",
"normalized": [
{
"... | [
{
"id": "5116",
"normalized": [
{
"db_id": "D029424",
"db_name": "MESH"
}
],
"offsets": [
[
73,
110
]
],
"text": [
"chronic obstructive pulmonary disease"
],
"type": "Disease"
},
{
"id": "5119",
"normalized": [... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"theophylline",
"theophylline",
"theophylline",
"ipratropium bromide",
"ipratropium bromide",
"ipratropium bromide"
] | [
"cardiovascular and gastrointestinal systems",
"cardiovascular",
"gastrointestinal systems",
"chronic obstructive pulmonary disease",
"cardiovascular",
"gastrointestinal systems"
] | [
{
"id": "5127",
"normalized": [
{
"db_id": "D002318",
"db_name": "MESH"
},
{
"db_id": "D005767",
"db_name": "MESH"
}
],
"offsets": [
[
997,
1040
]
],
"text": [
"cardiovascular and gastrointestinal syste... | [
{
"id": "5115",
"normalized": [
{
"db_id": "D013806",
"db_name": "MESH"
}
],
"offsets": [
[
57,
69
]
],
"text": [
"theophylline"
],
"type": "Chemical"
},
{
"id": "5115",
"normalized": [
{
"db_id":... | [
true,
true,
true,
true,
false,
false
] |
Irreversible damage to the medullary interstitium in experimental analgesic nephropathy in F344 rats. | Renal papillary necrosis (RPN) and a decreased urinary concentrating ability developed during continuous long-term treatment with aspirin and paracetamol in female Fischer 344 rats. Renal structure and concentrating ability were examined after a recovery period of up to 18 weeks, when no analgesics were given, to inves... | [
{
"id": "5167",
"normalized": [
{
"db_id": "D001241",
"db_name": "MESH"
}
],
"offsets": [
[
232,
239
]
],
"text": [
"aspirin"
],
"type": "Chemical"
},
{
"id": "5168",
"normalized": [
{
"db_id": "D... | [
{
"id": "5164",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
76,
87
]
],
"text": [
"nephropathy"
],
"type": "Disease"
},
{
"id": "5165",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"paracetamol",
"aspirin",
"paracetamol",
"aspirin"
] | [
"Renal papillary necrosis",
"Renal papillary necrosis",
"nephropathy",
"nephropathy"
] | [
{
"id": "5165",
"normalized": [
{
"db_id": "D007681",
"db_name": "MESH"
}
],
"offsets": [
[
102,
126
]
],
"text": [
"Renal papillary necrosis"
],
"type": "Disease"
},
{
"id": "5165",
"normalized": [
{
... | [
{
"id": "5168",
"normalized": [
{
"db_id": "D000082",
"db_name": "MESH"
}
],
"offsets": [
[
244,
255
]
],
"text": [
"paracetamol"
],
"type": "Chemical"
},
{
"id": "5167",
"normalized": [
{
"db_id"... | [
true,
true,
false,
false
] |
Less frequent lithium administration and lower urine volume. | OBJECTIVE: This study was designed to determine whether patients maintained on a regimen of lithium on a once-per-day schedule have lower urine volumes than do patients receiving multiple doses per day. METHOD: This was a cross-sectional study of 85 patients from a lithium clinic who received different dose schedules. ... | [
{
"id": "5179",
"normalized": [
{
"db_id": "D008094",
"db_name": "MESH"
}
],
"offsets": [
[
14,
21
]
],
"text": [
"lithium"
],
"type": "Chemical"
},
{
"id": "5180",
"normalized": [
{
"db_id": "D00... | [
{
"id": "5190",
"normalized": [
{
"db_id": "D011141",
"db_name": "MESH"
}
],
"offsets": [
[
862,
870
]
],
"text": [
"polyuria"
],
"type": "Disease"
}
] | [
"Yes",
"No"
] | [
"lithium",
"creatinine"
] | [
"polyuria",
"polyuria"
] | [
{
"id": "5190",
"normalized": [
{
"db_id": "D011141",
"db_name": "MESH"
}
],
"offsets": [
[
862,
870
]
],
"text": [
"polyuria"
],
"type": "Disease"
},
{
"id": "5190",
"normalized": [
{
"db_id": "D... | [
{
"id": "5179",
"normalized": [
{
"db_id": "D008094",
"db_name": "MESH"
}
],
"offsets": [
[
14,
21
]
],
"text": [
"lithium"
],
"type": "Chemical"
},
{
"id": "5183",
"normalized": [
{
"db_id": "D00... | [
true,
false
] |
Effect of adriamycin combined with whole body hyperthermia on tumor and normal tissues. | Thermal enhancement of Adriamycin-mediated antitumor activity and normal tissue toxicities by whole body hyperthermia were compared using a F344 rat model. Antitumor activity was studied using a tumor growth delay assay. Acute normal tissue toxicities (i.e., leukopenia and thrombocytopenia) and late normal tissue toxic... | [
{
"id": "5203",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
10,
20
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "5206",
"normalized": [
{
"db_id": "... | [
{
"id": "5204",
"normalized": [
{
"db_id": "D005334",
"db_name": "MESH"
}
],
"offsets": [
[
46,
58
]
],
"text": [
"hyperthermia"
],
"type": "Disease"
},
{
"id": "5205",
"normalized": [
{
"db_id": ... | [
"Yes",
"Yes",
"No",
"No"
] | [
"adriamycin",
"adriamycin",
"adriamycin",
"adriamycin"
] | [
"myocardial and kidney injury",
"myocardial",
"thrombocytopenia",
"leukopenia"
] | [
{
"id": "5214",
"normalized": [
{
"db_id": "D006331",
"db_name": "MESH"
},
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
421,
449
]
],
"text": [
"myocardial and kidney injury"
],
"... | [
{
"id": "5203",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
10,
20
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "5203",
"normalized": [
{
"db_id": "... | [
false,
false,
false,
false
] |
Prazosin-induced stress incontinence. | A case of genuine stress incontinence due to prazosin, a common antihypertensive drug, is presented. Prazosin exerts its antihypertensive effects through vasodilatation caused by selective blockade of postsynaptic alpha-1 adrenergic receptors. As an alpha-blocker, it also exerts a significant relaxant effect on the bla... | [
{
"id": "5244",
"normalized": [
{
"db_id": "D011224",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Prazosin"
],
"type": "Chemical"
},
{
"id": "5247",
"normalized": [
{
"db_id": "D011... | [
{
"id": "5245",
"normalized": [
{
"db_id": "D014550",
"db_name": "MESH"
}
],
"offsets": [
[
17,
36
]
],
"text": [
"stress incontinence"
],
"type": "Disease"
},
{
"id": "5246",
"normalized": [
{
"d... | [
"Yes",
"No"
] | [
"Prazosin",
"verapamil"
] | [
"stress incontinence",
"incontinence"
] | [
{
"id": "5245",
"normalized": [
{
"db_id": "D014550",
"db_name": "MESH"
}
],
"offsets": [
[
17,
36
]
],
"text": [
"stress incontinence"
],
"type": "Disease"
},
{
"id": "5251",
"normalized": [
{
"d... | [
{
"id": "5244",
"normalized": [
{
"db_id": "D011224",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Prazosin"
],
"type": "Chemical"
},
{
"id": "5250",
"normalized": [
{
"db_id": "D014... | [
true,
false
] |
Myocardial infarction following sublingual administration of isosorbide dinitrate. | A 78-year-old with healed septal necrosis suffered a recurrent myocardial infarction of the anterior wall following the administration of isosorbide dinitrate 5 mg sublingually. After detailing the course of events, we discuss the role of paradoxical coronary spasm and hypotension-mediated myocardial ischemia occurring... | [
{
"id": "5274",
"normalized": [
{
"db_id": "D007548",
"db_name": "MESH"
}
],
"offsets": [
[
61,
81
]
],
"text": [
"isosorbide dinitrate"
],
"type": "Chemical"
},
{
"id": "5277",
"normalized": [
{
... | [
{
"id": "5273",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
0,
21
]
],
"text": [
"Myocardial infarction"
],
"type": "Disease"
},
{
"id": "5275",
"normalized": [
{
"... | [
"Yes",
"No"
] | [
"isosorbide dinitrate",
"isosorbide dinitrate"
] | [
"Myocardial infarction",
"spasm"
] | [
{
"id": "5273",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
0,
21
]
],
"text": [
"Myocardial infarction"
],
"type": "Disease"
},
{
"id": "5278",
"normalized": [
{
"... | [
{
"id": "5274",
"normalized": [
{
"db_id": "D007548",
"db_name": "MESH"
}
],
"offsets": [
[
61,
81
]
],
"text": [
"isosorbide dinitrate"
],
"type": "Chemical"
},
{
"id": "5274",
"normalized": [
{
... | [
true,
false
] |
Fluoxetine-induced akathisia: clinical and theoretical implications. | Five patients receiving fluoxetine for the treatment of obsessive compulsive disorder or major depression developed akathisia. The typical fluoxetine-induced symptoms of restlessness, constant pacing, purposeless movements of the feet and legs, and marked anxiety were indistinguishable from those of neuroleptic-induced... | [
{
"id": "5290",
"normalized": [
{
"db_id": "D005473",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Fluoxetine"
],
"type": "Chemical"
},
{
"id": "5292",
"normalized": [
{
"db_id": "D... | [
{
"id": "5291",
"normalized": [
{
"db_id": "D017109",
"db_name": "MESH"
}
],
"offsets": [
[
19,
28
]
],
"text": [
"akathisia"
],
"type": "Disease"
},
{
"id": "5293",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"Fluoxetine",
"antidepressant"
] | [
"akathisia",
"akathisia"
] | [
{
"id": "5291",
"normalized": [
{
"db_id": "D017109",
"db_name": "MESH"
}
],
"offsets": [
[
19,
28
]
],
"text": [
"akathisia"
],
"type": "Disease"
},
{
"id": "5291",
"normalized": [
{
"db_id": "D0... | [
{
"id": "5290",
"normalized": [
{
"db_id": "D005473",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Fluoxetine"
],
"type": "Chemical"
},
{
"id": "5309",
"normalized": [
{
"db_id": "D... | [
true,
true
] |
Chronic active hepatitis associated with diclofenac sodium therapy. | Diclofenac sodium (Voltarol, Geigy Pharmaceuticals) is a non-steroidal anti-inflammatory derivative of phenylacetic acid. Although generally well-tolerated, asymptomatic abnormalities of liver function have been recorded and, less commonly, severe hepatitis induced by diclofenac. The patient described developed chronic... | [
{
"id": "5370",
"normalized": [
{
"db_id": "D004008",
"db_name": "MESH"
}
],
"offsets": [
[
41,
58
]
],
"text": [
"diclofenac sodium"
],
"type": "Chemical"
},
{
"id": "5371",
"normalized": [
{
"db... | [
{
"id": "5369",
"normalized": [
{
"db_id": "D006521",
"db_name": "MESH"
}
],
"offsets": [
[
0,
24
]
],
"text": [
"Chronic active hepatitis"
],
"type": "Disease"
},
{
"id": "5374",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"diclofenac sodium",
"phenylacetic acid"
] | [
"abnormalities of liver function",
"Chronic active hepatitis"
] | [
{
"id": "5374",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
}
],
"offsets": [
[
238,
269
]
],
"text": [
"abnormalities of liver function"
],
"type": "Disease"
},
{
"id": "5369",
"normalized": [
... | [
{
"id": "5370",
"normalized": [
{
"db_id": "D004008",
"db_name": "MESH"
}
],
"offsets": [
[
41,
58
]
],
"text": [
"diclofenac sodium"
],
"type": "Chemical"
},
{
"id": "5373",
"normalized": [
{
"db... | [
true,
false
] |
Stroke associated with cocaine use. | We describe eight patients in whom cocaine use was related to stroke and review 39 cases from the literature. Among these 47 patients the mean (+/- SD) age was 32.5 +/- 12.1 years; 76% (34/45) were men. Stroke followed cocaine use by inhalation, intranasal, intravenous, and intramuscular routes. Intracranial aneurysms ... | [
{
"id": "5393",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
23,
30
]
],
"text": [
"cocaine"
],
"type": "Chemical"
},
{
"id": "5394",
"normalized": [
{
"db_id": "D00... | [
{
"id": "5392",
"normalized": [
{
"db_id": "D020521",
"db_name": "MESH"
}
],
"offsets": [
[
0,
6
]
],
"text": [
"Stroke"
],
"type": "Disease"
},
{
"id": "5395",
"normalized": [
{
"db_id": "D020521... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"cocaine",
"cocaine",
"cocaine",
"cocaine",
"cocaine",
"cocaine"
] | [
"intracerebral hemorrhage",
"subarachnoid hemorrhage",
"Cerebral infarction",
"Intracranial aneurysms",
"intracranial hemorrhage",
"Stroke"
] | [
{
"id": "5402",
"normalized": [
{
"db_id": "D002543",
"db_name": "MESH"
}
],
"offsets": [
[
561,
585
]
],
"text": [
"intracerebral hemorrhage"
],
"type": "Disease"
},
{
"id": "5403",
"normalized": [
{
... | [
{
"id": "5393",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
23,
30
]
],
"text": [
"cocaine"
],
"type": "Chemical"
},
{
"id": "5393",
"normalized": [
{
"db_id": "D00... | [
false,
false,
true,
true,
true,
true
] |
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