origin_title stringlengths 27 249 | origin_abstract stringlengths 249 3.46k | chemical_entitiesList listlengths 1 42 | disease_entitiesList listlengths 1 33 | label listlengths 1 28 | head_chemical_entName listlengths 1 28 | tail_disease_entName listlengths 1 28 | tail_entity_dict listlengths 1 28 | head_entity_dict listlengths 1 28 | intra-sentence listlengths 1 28 |
|---|---|---|---|---|---|---|---|---|---|
Acute hepatitis attack after exposure to telithromycin. | INTRODUCTION: Antibiotic-associated hepatotoxicity is rare. With widespread use of antimicrobial agents, however, hepatic injury occurs frequently, and among adverse drug reactions, idiosyncratic reactions are the most serious. CASE SUMMARY: A 25-year-old male patient, with a height of 175 cm and weight of 72 kg presen... | [
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"db_name": "MESH"
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"text": [
"telithromycin"
],
"type": "Chemical"
},
{
"id": "20818",
"normalized": [
{
"db_i... | [
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"id": "20810",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
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"offsets": [
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6,
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"text": [
"hepatitis"
],
"type": "Disease"
},
{
"id": "20812",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"telithromycin",
"aspartate"
] | [
"hepatitis",
"jaundice"
] | [
{
"id": "20810",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
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"offsets": [
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6,
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"text": [
"hepatitis"
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"type": "Disease"
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{
"id": "20815",
"normalized": [
{
"db_id": "D... | [
{
"id": "20811",
"normalized": [
{
"db_id": "C106791",
"db_name": "MESH"
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"offsets": [
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41,
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"text": [
"telithromycin"
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"type": "Chemical"
},
{
"id": "20821",
"normalized": [
{
"db_i... | [
true,
false
] |
Spironolactone-induced renal insufficiency and hyperkalemia in patients with heart failure. | BACKGROUND: A previous randomized controlled trial evaluating the use of spironolactone in heart failure patients reported a low risk of hyperkalemia (2%) and renal insufficiency (0%). Because treatments for heart failure have changed since the benefits of spironolactone were reported, the prevalence of these complicat... | [
{
"id": "20896",
"normalized": [
{
"db_id": "D013148",
"db_name": "MESH"
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"offsets": [
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0,
14
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"text": [
"Spironolactone"
],
"type": "Chemical"
},
{
"id": "20900",
"normalized": [
{
"db_i... | [
{
"id": "20897",
"normalized": [
{
"db_id": "D051437",
"db_name": "MESH"
}
],
"offsets": [
[
23,
42
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],
"text": [
"renal insufficiency"
],
"type": "Disease"
},
{
"id": "20898",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"Spironolactone",
"Spironolactone",
"creatinine",
"K"
] | [
"hyperkalemia",
"renal insufficiency",
"hyperkalemia",
"heart failure"
] | [
{
"id": "20898",
"normalized": [
{
"db_id": "D006947",
"db_name": "MESH"
}
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"offsets": [
[
47,
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],
"text": [
"hyperkalemia"
],
"type": "Disease"
},
{
"id": "20897",
"normalized": [
{
"db_id"... | [
{
"id": "20896",
"normalized": [
{
"db_id": "D013148",
"db_name": "MESH"
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"offsets": [
[
0,
14
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"text": [
"Spironolactone"
],
"type": "Chemical"
},
{
"id": "20896",
"normalized": [
{
"db_i... | [
true,
true,
false,
false
] |
End-stage renal disease (ESRD) after orthotopic liver transplantation (OLTX) using calcineurin-based immunotherapy: risk of development and treatment. | BACKGROUND: The calcineurin inhibitors cyclosporine and tacrolimus are both known to be nephrotoxic. Their use in orthotopic liver transplantation (OLTX) has dramatically improved success rates. Recently, however, we have had an increase of patients who are presenting after OLTX with end-stage renal disease (ESRD). Thi... | [
{
"id": "21032",
"normalized": [
{
"db_id": "D016572",
"db_name": "MESH"
}
],
"offsets": [
[
190,
202
]
],
"text": [
"cyclosporine"
],
"type": "Chemical"
},
{
"id": "21033",
"normalized": [
{
"db_... | [
{
"id": "21030",
"normalized": [
{
"db_id": "D007676",
"db_name": "MESH"
}
],
"offsets": [
[
0,
23
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],
"text": [
"End-stage renal disease"
],
"type": "Disease"
},
{
"id": "21031",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"tacrolimus",
"cyclosporine",
"tacrolimus",
"cyclosporine"
] | [
"nephrotoxic",
"nephrotoxic",
"hepatorenal syndrome",
"hepatorenal syndrome"
] | [
{
"id": "21034",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
239,
250
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],
"text": [
"nephrotoxic"
],
"type": "Disease"
},
{
"id": "21034",
"normalized": [
{
"db_id... | [
{
"id": "21033",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
207,
217
]
],
"text": [
"tacrolimus"
],
"type": "Chemical"
},
{
"id": "21032",
"normalized": [
{
"db_id... | [
true,
true,
false,
false
] |
Effect of intravenous nimodipine on blood pressure and outcome after acute stroke. | BACKGROUND AND PURPOSE: The Intravenous Nimodipine West European Stroke Trial (INWEST) found a correlation between nimodipine-induced reduction in blood pressure (BP) and an unfavorable outcome in acute stroke. We sought to confirm this correlation with and without adjustment for prognostic variables and to investigate... | [
{
"id": "21078",
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{
"db_id": "D009553",
"db_name": "MESH"
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],
"offsets": [
[
22,
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],
"text": [
"nimodipine"
],
"type": "Chemical"
},
{
"id": "21080",
"normalized": [
{
"db_id":... | [
{
"id": "21079",
"normalized": [
{
"db_id": "D020521",
"db_name": "MESH"
}
],
"offsets": [
[
69,
81
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],
"text": [
"acute stroke"
],
"type": "Disease"
},
{
"id": "21081",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"nimodipine",
"nimodipine"
] | [
"reduction in blood pressure",
"acute stroke"
] | [
{
"id": "21083",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
217,
244
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],
"text": [
"reduction in blood pressure"
],
"type": "Disease"
},
{
"id": "21079",
"normalized": [
... | [
{
"id": "21078",
"normalized": [
{
"db_id": "D009553",
"db_name": "MESH"
}
],
"offsets": [
[
22,
32
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],
"text": [
"nimodipine"
],
"type": "Chemical"
},
{
"id": "21078",
"normalized": [
{
"db_id":... | [
true,
true
] |
Transient neurologic symptoms after spinal anesthesia: a lower incidence with prilocaine and bupivacaine than with lidocaine. | BACKGROUND: Recent evidence suggests that transient neurologic symptoms (TNSs) frequently follow lidocaine spinal anesthesia but are infrequent with bupivacaine. However, identification of a short-acting local anesthetic to substitute for lidocaine for brief surgical procedures remains an important goal. Prilocaine is ... | [
{
"id": "21148",
"normalized": [
{
"db_id": "D011318",
"db_name": "MESH"
}
],
"offsets": [
[
78,
88
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],
"text": [
"prilocaine"
],
"type": "Chemical"
},
{
"id": "21149",
"normalized": [
{
"db_id":... | [
{
"id": "21147",
"normalized": [
{
"db_id": "D009422",
"db_name": "MESH"
}
],
"offsets": [
[
0,
29
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],
"text": [
"Transient neurologic symptoms"
],
"type": "Disease"
},
{
"id": "21151",
"normalized": [
{... | [
"Yes",
"Yes",
"No",
"No"
] | [
"lidocaine",
"prilocaine",
"glucose",
"bupivacaine"
] | [
"Transient neurologic symptoms",
"Transient neurologic symptoms",
"Transient neurologic symptoms",
"Transient neurologic symptoms"
] | [
{
"id": "21147",
"normalized": [
{
"db_id": "D009422",
"db_name": "MESH"
}
],
"offsets": [
[
0,
29
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],
"text": [
"Transient neurologic symptoms"
],
"type": "Disease"
},
{
"id": "21147",
"normalized": [
{... | [
{
"id": "21150",
"normalized": [
{
"db_id": "D008012",
"db_name": "MESH"
}
],
"offsets": [
[
115,
124
]
],
"text": [
"lidocaine"
],
"type": "Chemical"
},
{
"id": "21148",
"normalized": [
{
"db_id"... | [
true,
true,
false,
true
] |
The role of nicotine in smoking-related cardiovascular disease. | Nicotine activates the sympathetic nervous system and in this way could contribute to cardiovascular disease. Animal studies and mechanistic studies indicate that nicotine could play a role in accelerating atherosclerosis, but evidence among humans is too inadequate to be definitive about such an effect. Almost certain... | [
{
"id": "21311",
"normalized": [
{
"db_id": "D009538",
"db_name": "MESH"
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],
"offsets": [
[
12,
20
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],
"text": [
"nicotine"
],
"type": "Chemical"
},
{
"id": "21313",
"normalized": [
{
"db_id": "... | [
{
"id": "21312",
"normalized": [
{
"db_id": "D002318",
"db_name": "MESH"
}
],
"offsets": [
[
40,
62
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],
"text": [
"cardiovascular disease"
],
"type": "Disease"
},
{
"id": "21314",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"nicotine",
"nicotine",
"carbon monoxide",
"carbon monoxide"
] | [
"cardiovascular disease",
"atherosclerosis",
"cardiovascular disease",
"atherosclerosis"
] | [
{
"id": "21312",
"normalized": [
{
"db_id": "D002318",
"db_name": "MESH"
}
],
"offsets": [
[
40,
62
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],
"text": [
"cardiovascular disease"
],
"type": "Disease"
},
{
"id": "21316",
"normalized": [
{
... | [
{
"id": "21311",
"normalized": [
{
"db_id": "D009538",
"db_name": "MESH"
}
],
"offsets": [
[
12,
20
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],
"text": [
"nicotine"
],
"type": "Chemical"
},
{
"id": "21311",
"normalized": [
{
"db_id": "... | [
true,
true,
false,
false
] |
Seizure resulting from a venlafaxine overdose. | OBJECTIVE: To report a case of venlafaxine overdose. CASE SUMMARY: A 40-year-old woman with major depression took an overdose of venlafaxine in an apparent suicide attempt. After the ingestion of 26 venlafaxine 50-mg tablets, the patient experienced a witnessed generalized seizure. She was admitted to the medical inten... | [
{
"id": "21360",
"normalized": [
{
"db_id": "C047426",
"db_name": "MESH"
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],
"offsets": [
[
25,
36
]
],
"text": [
"venlafaxine"
],
"type": "Chemical"
},
{
"id": "21362",
"normalized": [
{
"db_id"... | [
{
"id": "21359",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Seizure"
],
"type": "Disease"
},
{
"id": "21361",
"normalized": [
{
"db_id": "D062... | [
"Yes",
"Yes",
"No"
] | [
"venlafaxine",
"venlafaxine",
"venlafaxine"
] | [
"Seizure",
"overdose",
"major depression"
] | [
{
"id": "21359",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Seizure"
],
"type": "Disease"
},
{
"id": "21361",
"normalized": [
{
"db_id": "D062... | [
{
"id": "21360",
"normalized": [
{
"db_id": "C047426",
"db_name": "MESH"
}
],
"offsets": [
[
25,
36
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],
"text": [
"venlafaxine"
],
"type": "Chemical"
},
{
"id": "21360",
"normalized": [
{
"db_id"... | [
true,
true,
true
] |
Effect of nifedipine on renal function in liver transplant recipients receiving tacrolimus. | The effect of nifedipine on renal function in liver transplant recipients who were receiving tacrolimus was evaluated between January 1992 and January 1996. Two groups of patients receiving tacrolimus were compared over a period of 1 year, one group comprising hypertensive patients who were receiving nifedipine, and th... | [
{
"id": "21452",
"normalized": [
{
"db_id": "D009543",
"db_name": "MESH"
}
],
"offsets": [
[
10,
20
]
],
"text": [
"nifedipine"
],
"type": "Chemical"
},
{
"id": "21453",
"normalized": [
{
"db_id":... | [
{
"id": "21457",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
353,
365
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],
"text": [
"hypertensive"
],
"type": "Disease"
},
{
"id": "21463",
"normalized": [
{
"db_i... | [
"Yes",
"No"
] | [
"tacrolimus",
"creatinine"
] | [
"hypertensive",
"nephrotoxicity"
] | [
{
"id": "21457",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
353,
365
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],
"text": [
"hypertensive"
],
"type": "Disease"
},
{
"id": "21463",
"normalized": [
{
"db_i... | [
{
"id": "21453",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
80,
90
]
],
"text": [
"tacrolimus"
],
"type": "Chemical"
},
{
"id": "21461",
"normalized": [
{
"db_id":... | [
true,
false
] |
Sinus arrest associated with continuous-infusion cimetidine. | The administration of intermittent intravenous infusions of cimetidine is infrequently associated with the development of bradyarrhythmias. A 40-year-old man with leukemia and no history of cardiac disease developed recurrent, brief episodes of apparent sinus arrest while receiving continuous-infusion cimetidine 50 mg/... | [
{
"id": "21478",
"normalized": [
{
"db_id": "D002927",
"db_name": "MESH"
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],
"offsets": [
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49,
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],
"text": [
"cimetidine"
],
"type": "Chemical"
},
{
"id": "21479",
"normalized": [
{
"db_id":... | [
{
"id": "21477",
"normalized": [
{
"db_id": "D054138",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Sinus arrest"
],
"type": "Disease"
},
{
"id": "21480",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"No",
"No"
] | [
"cimetidine",
"cimetidine",
"cimetidine",
"cimetidine"
] | [
"Sinus arrest",
"bradyarrhythmias",
"leukemia",
"arrhythmias"
] | [
{
"id": "21477",
"normalized": [
{
"db_id": "D054138",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
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],
"text": [
"Sinus arrest"
],
"type": "Disease"
},
{
"id": "21480",
"normalized": [
{
"db_id":... | [
{
"id": "21478",
"normalized": [
{
"db_id": "D002927",
"db_name": "MESH"
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],
"offsets": [
[
49,
59
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],
"text": [
"cimetidine"
],
"type": "Chemical"
},
{
"id": "21478",
"normalized": [
{
"db_id":... | [
true,
true,
true,
true
] |
Composition of gall bladder stones associated with octreotide: response to oral ursodeoxycholic acid. | Octreotide, an effective treatment for acromegaly, induces gall bladder stones in 13-60% of patients. Because knowledge of stone composition is essential for studies of their pathogenesis, treatment, and prevention, this was investigated by direct and indirect methods in 14 octreotide treated acromegalic patients with ... | [
{
"id": "21514",
"normalized": [
{
"db_id": "D015282",
"db_name": "MESH"
}
],
"offsets": [
[
51,
61
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],
"text": [
"octreotide"
],
"type": "Chemical"
},
{
"id": "21515",
"normalized": [
{
"db_id":... | [
{
"id": "21513",
"normalized": [
{
"db_id": "D042882",
"db_name": "MESH"
}
],
"offsets": [
[
15,
34
]
],
"text": [
"gall bladder stones"
],
"type": "Disease"
},
{
"id": "21517",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"octreotide",
"ursodeoxycholic acid"
] | [
"gall bladder stones",
"acromegaly"
] | [
{
"id": "21513",
"normalized": [
{
"db_id": "D042882",
"db_name": "MESH"
}
],
"offsets": [
[
15,
34
]
],
"text": [
"gall bladder stones"
],
"type": "Disease"
},
{
"id": "21517",
"normalized": [
{
... | [
{
"id": "21514",
"normalized": [
{
"db_id": "D015282",
"db_name": "MESH"
}
],
"offsets": [
[
51,
61
]
],
"text": [
"octreotide"
],
"type": "Chemical"
},
{
"id": "21515",
"normalized": [
{
"db_id":... | [
true,
false
] |
Cardiovascular complications associated with terbutaline treatment for preterm labor. | Severe cardiovascular complications occurred in eight of 160 patients treated with terbutaline for preterm labor. Associated corticosteroid therapy and twin gestations appear to be predisposing factors. Potential mechanisms of the pathophysiology are briefly discussed. | [
{
"id": "21580",
"normalized": [
{
"db_id": "D013726",
"db_name": "MESH"
}
],
"offsets": [
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45,
56
]
],
"text": [
"terbutaline"
],
"type": "Chemical"
},
{
"id": "21583",
"normalized": [
{
"db_id"... | [
{
"id": "21579",
"normalized": [
{
"db_id": "D002318",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
]
],
"text": [
"Cardiovascular complications"
],
"type": "Disease"
},
{
"id": "21581",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"terbutaline",
"terbutaline"
] | [
"Cardiovascular complications",
"preterm labor"
] | [
{
"id": "21579",
"normalized": [
{
"db_id": "D002318",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
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],
"text": [
"Cardiovascular complications"
],
"type": "Disease"
},
{
"id": "21581",
"normalized": [
{
... | [
{
"id": "21580",
"normalized": [
{
"db_id": "D013726",
"db_name": "MESH"
}
],
"offsets": [
[
45,
56
]
],
"text": [
"terbutaline"
],
"type": "Chemical"
},
{
"id": "21580",
"normalized": [
{
"db_id"... | [
true,
true
] |
Neurologic effects of subarachnoid administration of 2-chloroprocaine-CE, bupivacaine, and low pH normal saline in dogs. | The purpose of this study was to evaluate the neurologic consequences of deliberate subarachnoid injection of large volumes of 2-chloroprocaine-CE in experimental animals. The possible role of low pH as well as total volume as potential factors in causing neurotoxicity was evaluated. The 65 dogs in the study received i... | [
{
"id": "21592",
"normalized": [
{
"db_id": "C004616",
"db_name": "MESH"
}
],
"offsets": [
[
53,
72
]
],
"text": [
"2-chloroprocaine-CE"
],
"type": "Chemical"
},
{
"id": "21593",
"normalized": [
{
... | [
{
"id": "21595",
"normalized": [
{
"db_id": "D020258",
"db_name": "MESH"
}
],
"offsets": [
[
377,
390
]
],
"text": [
"neurotoxicity"
],
"type": "Disease"
},
{
"id": "21599",
"normalized": [
{
"db_... | [
"Yes",
"Yes",
"No",
"No"
] | [
"2-chloroprocaine-CE",
"2-chloroprocaine-CE",
"bupivacaine",
"2-chloroprocaine-CE"
] | [
"paralysis",
"subpial necrosis",
"paralysis",
"neurotoxicity"
] | [
{
"id": "21599",
"normalized": [
{
"db_id": "D010243",
"db_name": "MESH"
}
],
"offsets": [
[
731,
740
]
],
"text": [
"paralysis"
],
"type": "Disease"
},
{
"id": "21603",
"normalized": [
{
"db_id":... | [
{
"id": "21592",
"normalized": [
{
"db_id": "C004616",
"db_name": "MESH"
}
],
"offsets": [
[
53,
72
]
],
"text": [
"2-chloroprocaine-CE"
],
"type": "Chemical"
},
{
"id": "21592",
"normalized": [
{
... | [
true,
true,
true,
false
] |
Early adjuvant adriamycin in superficial bladder carcinoma. | A multicenter study was performed in 110 patients with superficial transitional cell carcinoma of the bladder. Adriamycin (50 mg/50 ml) was administered intravesically within 24 h after transurethral resection of TA-T1 (O-A) bladder tumors. Instillation was repeated twice during the first week, then weekly during the f... | [
{
"id": "21623",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
15,
25
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "21630",
"normalized": [
{
"db_id":... | [
{
"id": "21624",
"normalized": [
{
"db_id": "D001749",
"db_name": "MESH"
},
{
"db_id": "D002277",
"db_name": "MESH"
}
],
"offsets": [
[
41,
58
]
],
"text": [
"bladder carcinoma"
],
"type": "Dise... | [
"Yes",
"No"
] | [
"adriamycin",
"adriamycin"
] | [
"cystitis",
"tumors"
] | [
{
"id": "21632",
"normalized": [
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
561,
569
]
],
"text": [
"cystitis"
],
"type": "Disease"
},
{
"id": "21633",
"normalized": [
{
"db_id": ... | [
{
"id": "21623",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
15,
25
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "21623",
"normalized": [
{
"db_id":... | [
false,
false
] |
Hyperkalemia associated with sulindac therapy. | Hyperkalemia has recently been recognized as a complication of nonsteroidal antiinflammatory agents (NSAID) such as indomethacin. Several recent studies have stressed the renal sparing features of sulindac, owing to its lack of interference with renal prostacyclin synthesis. We describe 4 patients in whom hyperkalemia ... | [
{
"id": "21643",
"normalized": [
{
"db_id": "D013467",
"db_name": "MESH"
}
],
"offsets": [
[
29,
37
]
],
"text": [
"sulindac"
],
"type": "Chemical"
},
{
"id": "21645",
"normalized": [
{
"db_id": "... | [
{
"id": "21642",
"normalized": [
{
"db_id": "D006947",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Hyperkalemia"
],
"type": "Disease"
},
{
"id": "21644",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"No",
"No"
] | [
"indomethacin",
"sulindac",
"potassium",
"prostacyclin"
] | [
"Hyperkalemia",
"Hyperkalemia",
"Hyperkalemia",
"Hyperkalemia"
] | [
{
"id": "21642",
"normalized": [
{
"db_id": "D006947",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Hyperkalemia"
],
"type": "Disease"
},
{
"id": "21642",
"normalized": [
{
"db_id":... | [
{
"id": "21645",
"normalized": [
{
"db_id": "D007213",
"db_name": "MESH"
}
],
"offsets": [
[
163,
175
]
],
"text": [
"indomethacin"
],
"type": "Chemical"
},
{
"id": "21643",
"normalized": [
{
"db_... | [
true,
true,
true,
false
] |
Ventricular tachyarrhythmias during cesarean section after ritodrine therapy: interaction with anesthetics. | This case illustrates that patients receiving ritodrine for preterm labor may risk interactions between the residual betamimetic effects of ritodrine and the effects of anesthetics during cesarean section. Such interactions may result in serious cardiovascular complications even after cessation of an infusion of ritodr... | [
{
"id": "21688",
"normalized": [
{
"db_id": "D012312",
"db_name": "MESH"
}
],
"offsets": [
[
59,
68
]
],
"text": [
"ritodrine"
],
"type": "Chemical"
},
{
"id": "21689",
"normalized": [
{
"db_id": ... | [
{
"id": "21687",
"normalized": [
{
"db_id": "D014693",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
]
],
"text": [
"Ventricular tachyarrhythmias"
],
"type": "Disease"
},
{
"id": "21690",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"ritodrine",
"ephedrine"
] | [
"Ventricular tachyarrhythmias",
"tachycardia"
] | [
{
"id": "21687",
"normalized": [
{
"db_id": "D014693",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
]
],
"text": [
"Ventricular tachyarrhythmias"
],
"type": "Disease"
},
{
"id": "21698",
"normalized": [
{
... | [
{
"id": "21688",
"normalized": [
{
"db_id": "D012312",
"db_name": "MESH"
}
],
"offsets": [
[
59,
68
]
],
"text": [
"ritodrine"
],
"type": "Chemical"
},
{
"id": "21695",
"normalized": [
{
"db_id": ... | [
true,
false
] |
Immunohistochemical, electron microscopic and morphometric studies of estrogen-induced rat prolactinomas after bromocriptine treatment. | To clarify the effects of bromocriptine on prolactinoma cells in vivo, immunohistochemical, ultrastructural and morphometrical analyses were applied to estrogen-induced rat prolactinoma cells 1 h and 6 h after injection of bromocriptine (3 mg/kg of body weight). One h after treatment, serum prolactin levels decreased m... | [
{
"id": "21706",
"normalized": [
{
"db_id": "D004967",
"db_name": "MESH"
}
],
"offsets": [
[
70,
78
]
],
"text": [
"estrogen"
],
"type": "Chemical"
},
{
"id": "21708",
"normalized": [
{
"db_id": "... | [
{
"id": "21707",
"normalized": [
{
"db_id": "D015175",
"db_name": "MESH"
}
],
"offsets": [
[
91,
104
]
],
"text": [
"prolactinomas"
],
"type": "Disease"
},
{
"id": "21710",
"normalized": [
{
"db_i... | [
"Yes",
"No"
] | [
"estrogen",
"bromocriptine"
] | [
"prolactinomas",
"prolactinomas"
] | [
{
"id": "21707",
"normalized": [
{
"db_id": "D015175",
"db_name": "MESH"
}
],
"offsets": [
[
91,
104
]
],
"text": [
"prolactinomas"
],
"type": "Disease"
},
{
"id": "21707",
"normalized": [
{
"db_i... | [
{
"id": "21706",
"normalized": [
{
"db_id": "D004967",
"db_name": "MESH"
}
],
"offsets": [
[
70,
78
]
],
"text": [
"estrogen"
],
"type": "Chemical"
},
{
"id": "21708",
"normalized": [
{
"db_id": "... | [
true,
true
] |
On two paradoxical side-effects of prednisolone in rats, ribosomal RNA biosyntheses, and a mechanism of action. | Liver enlargement and muscle wastage occurred in Wistar rats following the subcutaneous administration of prednisolone. In the liver both the content of RNA and the biosynthesis of ribosomal RNA increased while both the RNA content and ribosomal RNA biosynthesis were reduced in the gastrocnemius muscle. It is suggested... | [
{
"id": "21736",
"normalized": [
{
"db_id": "D011239",
"db_name": "MESH"
}
],
"offsets": [
[
35,
47
]
],
"text": [
"prednisolone"
],
"type": "Chemical"
},
{
"id": "21739",
"normalized": [
{
"db_id... | [
{
"id": "21737",
"normalized": [
{
"db_id": "D006529",
"db_name": "MESH"
}
],
"offsets": [
[
112,
129
]
],
"text": [
"Liver enlargement"
],
"type": "Disease"
},
{
"id": "21738",
"normalized": [
{
... | [
"Yes",
"Yes"
] | [
"prednisolone",
"prednisolone"
] | [
"Liver enlargement",
"muscle wastage"
] | [
{
"id": "21737",
"normalized": [
{
"db_id": "D006529",
"db_name": "MESH"
}
],
"offsets": [
[
112,
129
]
],
"text": [
"Liver enlargement"
],
"type": "Disease"
},
{
"id": "21738",
"normalized": [
{
... | [
{
"id": "21736",
"normalized": [
{
"db_id": "D011239",
"db_name": "MESH"
}
],
"offsets": [
[
35,
47
]
],
"text": [
"prednisolone"
],
"type": "Chemical"
},
{
"id": "21736",
"normalized": [
{
"db_id... | [
true,
true
] |
Possible intramuscular midazolam-associated cardiorespiratory arrest and death. | Midazolam hydrochloride is commonly used for dental or endoscopic procedures. Although generally consisted safe when given intramuscularly, intravenous administration is known to cause respiratory and cardiovascular depression. This report describes the first published case of cardiorespiratory arrest and death associa... | [
{
"id": "21750",
"normalized": [
{
"db_id": "D008874",
"db_name": "MESH"
}
],
"offsets": [
[
23,
32
]
],
"text": [
"midazolam"
],
"type": "Chemical"
},
{
"id": "21753",
"normalized": [
{
"db_id": ... | [
{
"id": "21751",
"normalized": [
{
"db_id": "D006323",
"db_name": "MESH"
}
],
"offsets": [
[
44,
68
]
],
"text": [
"cardiorespiratory arrest"
],
"type": "Disease"
},
{
"id": "21752",
"normalized": [
{
... | [
"Yes",
"Yes",
"Yes",
"No"
] | [
"midazolam",
"midazolam",
"midazolam",
"midazolam"
] | [
"respiratory and cardiovascular depression",
"respiratory",
"cardiorespiratory arrest",
"death"
] | [
{
"id": "21754",
"normalized": [
{
"db_id": "D012140",
"db_name": "MESH"
},
{
"db_id": "D002318",
"db_name": "MESH"
}
],
"offsets": [
[
265,
306
]
],
"text": [
"respiratory and cardiovascular depression... | [
{
"id": "21750",
"normalized": [
{
"db_id": "D008874",
"db_name": "MESH"
}
],
"offsets": [
[
23,
32
]
],
"text": [
"midazolam"
],
"type": "Chemical"
},
{
"id": "21750",
"normalized": [
{
"db_id": ... | [
false,
false,
true,
true
] |
Serial epilepsy caused by levodopa/carbidopa administration in two patients on hemodialysis. | Two patients with similar clinical features are presented: both patients had chronic renal failure, on hemodialysis for many years but recently begun on a high-flux dialyzer; both had been receiving a carbidopa/levodopa preparation; and both had the onset of hallucinosis and recurrent seizures, which were refractory to... | [
{
"id": "21781",
"normalized": [
{
"db_id": "C009265",
"db_name": "MESH"
}
],
"offsets": [
[
26,
44
]
],
"text": [
"levodopa/carbidopa"
],
"type": "Chemical"
},
{
"id": "21783",
"normalized": [
{
... | [
{
"id": "21780",
"normalized": [
{
"db_id": "D004827",
"db_name": "MESH"
}
],
"offsets": [
[
7,
15
]
],
"text": [
"epilepsy"
],
"type": "Disease"
},
{
"id": "21782",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"levodopa/carbidopa",
"vitamin B6"
] | [
"epilepsy",
"epilepsy"
] | [
{
"id": "21780",
"normalized": [
{
"db_id": "D004827",
"db_name": "MESH"
}
],
"offsets": [
[
7,
15
]
],
"text": [
"epilepsy"
],
"type": "Disease"
},
{
"id": "21780",
"normalized": [
{
"db_id": "D0... | [
{
"id": "21781",
"normalized": [
{
"db_id": "C009265",
"db_name": "MESH"
}
],
"offsets": [
[
26,
44
]
],
"text": [
"levodopa/carbidopa"
],
"type": "Chemical"
},
{
"id": "21786",
"normalized": [
{
... | [
true,
false
] |
Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. | The present study was carried out to test the effects of L-alpha-glycerylphosphorylcholine (L-alpha-GFC) on memory impairment induced by scopolamine in man. Thirty-two healthy young volunteers were randomly allocated to four different groups. They were given a ten day pretreatment with either L-alpha-GFC or placebo, p.... | [
{
"id": "21792",
"normalized": [
{
"db_id": "D005997",
"db_name": "MESH"
}
],
"offsets": [
[
10,
44
]
],
"text": [
"L-alpha-glyceryl-phosphorylcholine"
],
"type": "Chemical"
},
{
"id": "21794",
"normalized": [
... | [
{
"id": "21793",
"normalized": [
{
"db_id": "D000647",
"db_name": "MESH"
}
],
"offsets": [
[
48,
55
]
],
"text": [
"amnesia"
],
"type": "Disease"
},
{
"id": "21797",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"scopolamine",
"L-alpha-glyceryl-phosphorylcholine"
] | [
"memory impairment",
"amnesia"
] | [
{
"id": "21797",
"normalized": [
{
"db_id": "D008569",
"db_name": "MESH"
}
],
"offsets": [
[
187,
204
]
],
"text": [
"memory impairment"
],
"type": "Disease"
},
{
"id": "21793",
"normalized": [
{
... | [
{
"id": "21794",
"normalized": [
{
"db_id": "D012601",
"db_name": "MESH"
}
],
"offsets": [
[
66,
77
]
],
"text": [
"scopolamine"
],
"type": "Chemical"
},
{
"id": "21792",
"normalized": [
{
"db_id"... | [
true,
true
] |
Seizures induced by the cocaine metabolite benzoylecgonine in rats. | The half-life (t1/2) of cocaine is relatively short, but some of the consequences of its use, such as seizures and strokes, can occur hours after exposure. This led us to hypothesize that a metabolite of cocaine may be responsible for some of those delayed sequelae. We evaluated the potential of the major metabolite of... | [
{
"id": "21815",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
24,
31
]
],
"text": [
"cocaine"
],
"type": "Chemical"
},
{
"id": "21816",
"normalized": [
{
"db_id": "C... | [
{
"id": "21814",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Seizures"
],
"type": "Disease"
},
{
"id": "21818",
"normalized": [
{
"db_id": "D01... | [
"Yes",
"Yes",
"No",
"No"
] | [
"cocaine",
"benzoylecgonine",
"cocaine",
"cocaine"
] | [
"Seizures",
"Seizures",
"death",
"strokes"
] | [
{
"id": "21814",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Seizures"
],
"type": "Disease"
},
{
"id": "21814",
"normalized": [
{
"db_id": "D01... | [
{
"id": "21815",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
24,
31
]
],
"text": [
"cocaine"
],
"type": "Chemical"
},
{
"id": "21816",
"normalized": [
{
"db_id": "C... | [
true,
true,
true,
true
] |
Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist. | LY274614, 3SR,4aRS,6SR,8aRS-6-[phosphonomethyl]decahydr oisoquinoline-3- carboxylic acid, has been described as a potent antagonist of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor. Here its ability to antagonize the prolonged depletion of dopamine in the striatum by amphetamine in iprindole-treated rat... | [
{
"id": "22092",
"normalized": [
{
"db_id": "D000661",
"db_name": "MESH"
}
],
"offsets": [
[
19,
30
]
],
"text": [
"amphetamine"
],
"type": "Chemical"
},
{
"id": "22094",
"normalized": [
{
"db_id"... | [
{
"id": "22093",
"normalized": [
{
"db_id": "D020258",
"db_name": "MESH"
}
],
"offsets": [
[
39,
52
]
],
"text": [
"neurotoxicity"
],
"type": "Disease"
},
{
"id": "22127",
"normalized": [
{
"db_id... | [
"Yes",
"No"
] | [
"amphetamine",
"LY274614"
] | [
"neurotoxicity",
"neurotoxicity"
] | [
{
"id": "22093",
"normalized": [
{
"db_id": "D020258",
"db_name": "MESH"
}
],
"offsets": [
[
39,
52
]
],
"text": [
"neurotoxicity"
],
"type": "Disease"
},
{
"id": "22093",
"normalized": [
{
"db_id... | [
{
"id": "22092",
"normalized": [
{
"db_id": "D000661",
"db_name": "MESH"
}
],
"offsets": [
[
19,
30
]
],
"text": [
"amphetamine"
],
"type": "Chemical"
},
{
"id": "22095",
"normalized": [
{
"db_id"... | [
true,
true
] |
Neonatal pyridoxine responsive convulsions due to isoniazid therapy. | A 17-day-old infant on isoniazid therapy 13 mg/kg daily from birth because of maternal tuberculosis was admitted after 4 days of clonic fits. No underlying infective or biochemical cause could be found. The fits ceased within 4 hours of administering intramuscular pyridoxine, suggesting an aetiology of pyridoxine defic... | [
{
"id": "22152",
"normalized": [
{
"db_id": "D011736",
"db_name": "MESH"
}
],
"offsets": [
[
9,
19
]
],
"text": [
"pyridoxine"
],
"type": "Chemical"
},
{
"id": "22154",
"normalized": [
{
"db_id": ... | [
{
"id": "22153",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
31,
42
]
],
"text": [
"convulsions"
],
"type": "Disease"
},
{
"id": "22156",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
] | [
"isoniazid",
"isoniazid"
] | [
"convulsions",
"tuberculosis"
] | [
{
"id": "22153",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
31,
42
]
],
"text": [
"convulsions"
],
"type": "Disease"
},
{
"id": "22156",
"normalized": [
{
"db_id":... | [
{
"id": "22154",
"normalized": [
{
"db_id": "D007538",
"db_name": "MESH"
}
],
"offsets": [
[
50,
59
]
],
"text": [
"isoniazid"
],
"type": "Chemical"
},
{
"id": "22154",
"normalized": [
{
"db_id": ... | [
true,
true
] |
Reversal by phenylephrine of the beneficial effects of intravenous nitroglycerin in patients with acute myocardial infarction. | Nitroglycerin has been shown to reduce ST-segment elevation during acute myocardial infarction, an effect potentiated in the dog by agents that reverse nitroglycerin-induced hypotension. Our study was designed to determine the effects of combined nitroglycerin and phenylephrine therapy. Ten patients with acute transmur... | [
{
"id": "22174",
"normalized": [
{
"db_id": "D010656",
"db_name": "MESH"
}
],
"offsets": [
[
12,
25
]
],
"text": [
"phenylephrine"
],
"type": "Chemical"
},
{
"id": "22175",
"normalized": [
{
"db_i... | [
{
"id": "22176",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
98,
125
]
],
"text": [
"acute myocardial infarction"
],
"type": "Disease"
},
{
"id": "22178",
"normalized": [
{... | [
"Yes",
"No"
] | [
"nitroglycerin",
"phenylephrine"
] | [
"hypotension",
"hypotension"
] | [
{
"id": "22180",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
301,
312
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "22180",
"normalized": [
{
"db_id... | [
{
"id": "22175",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
67,
80
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "22174",
"normalized": [
{
"db_i... | [
true,
false
] |
Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. | PURPOSE: This study was designed to establish a rat model of thoracic aortic aneurysm (TAA) by calcium chloride (CaCl(2))-induced arterial injury and to explore the potential role of a disintegrin and metalloproteinase (ADAM), matrix metalloproteinases (MMPs) and their endogenous inhibitors (TIMPs) in TAA formation. ME... | [
{
"id": "22200",
"normalized": [
{
"db_id": "D002122",
"db_name": "MESH"
}
],
"offsets": [
[
89,
94
]
],
"text": [
"CaCl2"
],
"type": "Chemical"
},
{
"id": "22204",
"normalized": [
{
"db_id": "D00... | [
{
"id": "22201",
"normalized": [
{
"db_id": "D017545",
"db_name": "MESH"
}
],
"offsets": [
[
103,
127
]
],
"text": [
"thoracic aortic aneurysm"
],
"type": "Disease"
},
{
"id": "22202",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"CaCl2",
"NaCl"
] | [
"thoracic aortic aneurysm",
"arterial injury"
] | [
{
"id": "22201",
"normalized": [
{
"db_id": "D017545",
"db_name": "MESH"
}
],
"offsets": [
[
103,
127
]
],
"text": [
"thoracic aortic aneurysm"
],
"type": "Disease"
},
{
"id": "22206",
"normalized": [
{
... | [
{
"id": "22200",
"normalized": [
{
"db_id": "D002122",
"db_name": "MESH"
}
],
"offsets": [
[
89,
94
]
],
"text": [
"CaCl2"
],
"type": "Chemical"
},
{
"id": "22209",
"normalized": [
{
"db_id": "D01... | [
true,
false
] |
When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration. | Twenty-three hours after heart transplantation, life-threatening acute right heart failure was diagnosed in a patient requiring continuous venovenous hemodiafiltration (CVVHDF). Increasing doses of catecholamines, sedatives, and muscle relaxants administered through a central venous catheter were ineffective. However, ... | [
{
"id": "22292",
"normalized": [
{
"db_id": "D002395",
"db_name": "MESH"
}
],
"offsets": [
[
297,
311
]
],
"text": [
"catecholamines"
],
"type": "Chemical"
},
{
"id": "22293",
"normalized": [
{
"d... | [
{
"id": "22291",
"normalized": [
{
"db_id": "D006333",
"db_name": "MESH"
}
],
"offsets": [
[
170,
189
]
],
"text": [
"right heart failure"
],
"type": "Disease"
},
{
"id": "22294",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"epinephrine",
"catecholamines"
] | [
"hypertensive",
"hypertensive"
] | [
{
"id": "22294",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
494,
506
]
],
"text": [
"hypertensive"
],
"type": "Disease"
},
{
"id": "22294",
"normalized": [
{
"db_i... | [
{
"id": "22293",
"normalized": [
{
"db_id": "D004837",
"db_name": "MESH"
}
],
"offsets": [
[
430,
441
]
],
"text": [
"epinephrine"
],
"type": "Chemical"
},
{
"id": "22292",
"normalized": [
{
"db_i... | [
true,
false
] |
Long-term glutamate supplementation failed to protect against peripheral neurotoxicity of paclitaxel. | Toxic peripheral neuropathy is still a significant limiting factor for chemotherapy with paclitaxel (PAC), although glutamate and its closely related amino acid glutamine were claimed to ameliorate PAC neurotoxicity. This pilot trial aimed to evaluate the role of glutamate supplementation for preventing PAC-induced per... | [
{
"id": "22300",
"normalized": [
{
"db_id": "D018698",
"db_name": "MESH"
}
],
"offsets": [
[
10,
19
]
],
"text": [
"glutamate"
],
"type": "Chemical"
},
{
"id": "22302",
"normalized": [
{
"db_id": ... | [
{
"id": "22301",
"normalized": [
{
"db_id": "D010523",
"db_name": "MESH"
}
],
"offsets": [
[
62,
86
]
],
"text": [
"peripheral neurotoxicity"
],
"type": "Disease"
},
{
"id": "22303",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"paclitaxel",
"glutamate"
] | [
"peripheral neurotoxicity",
"neurotoxicity"
] | [
{
"id": "22301",
"normalized": [
{
"db_id": "D010523",
"db_name": "MESH"
}
],
"offsets": [
[
62,
86
]
],
"text": [
"peripheral neurotoxicity"
],
"type": "Disease"
},
{
"id": "22310",
"normalized": [
{
... | [
{
"id": "22302",
"normalized": [
{
"db_id": "D017239",
"db_name": "MESH"
}
],
"offsets": [
[
90,
100
]
],
"text": [
"paclitaxel"
],
"type": "Chemical"
},
{
"id": "22300",
"normalized": [
{
"db_id"... | [
true,
true
] |
Attentional modulation of perceived pain intensity in capsaicin-induced secondary hyperalgesia. | Perceived pain intensity is modulated by attention. However, it is not known that how pain intensity ratings are affected by attention in capsaicin-induced secondary hyperalgesia. Here we show that perceived pain intensity in secondary hyperalgesia is decreased when attention is distracted away from the painful pinpric... | [
{
"id": "22354",
"normalized": [
{
"db_id": "D002211",
"db_name": "MESH"
}
],
"offsets": [
[
54,
63
]
],
"text": [
"capsaicin"
],
"type": "Chemical"
},
{
"id": "22358",
"normalized": [
{
"db_id": ... | [
{
"id": "22353",
"normalized": [
{
"db_id": "D010146",
"db_name": "MESH"
}
],
"offsets": [
[
36,
40
]
],
"text": [
"pain"
],
"type": "Disease"
},
{
"id": "22355",
"normalized": [
{
"db_id": "D0069... | [
"Yes",
"No"
] | [
"capsaicin",
"capsaicin"
] | [
"hyperalgesia",
"pain"
] | [
{
"id": "22355",
"normalized": [
{
"db_id": "D006930",
"db_name": "MESH"
}
],
"offsets": [
[
82,
94
]
],
"text": [
"hyperalgesia"
],
"type": "Disease"
},
{
"id": "22353",
"normalized": [
{
"db_id"... | [
{
"id": "22354",
"normalized": [
{
"db_id": "D002211",
"db_name": "MESH"
}
],
"offsets": [
[
54,
63
]
],
"text": [
"capsaicin"
],
"type": "Chemical"
},
{
"id": "22354",
"normalized": [
{
"db_id": ... | [
true,
true
] |
Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats. | Blood pressure (BP) is more salt sensitive in men than in premenopausal women. In Dahl salt-sensitive rats (DS), high-salt (HS) diet increases BP more in males than females. In contrast to the systemic renin-angiotensin system, which is suppressed in response to HS in male DS, intrarenal angiotensinogen expression is i... | [
{
"id": "22396",
"normalized": [
{
"db_id": "D013739",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Testosterone"
],
"type": "Chemical"
},
{
"id": "22398",
"normalized": [
{
"db_id"... | [
{
"id": "22397",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
23,
35
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "22404",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"salt",
"Testosterone"
] | [
"renal injury",
"hypertension"
] | [
{
"id": "22404",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
688,
700
]
],
"text": [
"renal injury"
],
"type": "Disease"
},
{
"id": "22397",
"normalized": [
{
"db_i... | [
{
"id": "22398",
"normalized": [
{
"db_id": "D017673",
"db_name": "MESH"
}
],
"offsets": [
[
91,
95
]
],
"text": [
"salt"
],
"type": "Chemical"
},
{
"id": "22396",
"normalized": [
{
"db_id": "D013... | [
false,
true
] |
Prenatal protein deprivation alters dopamine-mediated behaviors and dopaminergic and glutamatergic receptor binding. | Epidemiological evidence indicates that prenatal nutritional deprivation may increase the risk of schizophrenia. The goal of these studies was to use an animal model to examine the effects of prenatal protein deprivation on behaviors and receptor binding with relevance to schizophrenia. We report that prenatally protei... | [
{
"id": "22436",
"normalized": [
{
"db_id": "D004298",
"db_name": "MESH"
}
],
"offsets": [
[
36,
44
]
],
"text": [
"dopamine"
],
"type": "Chemical"
},
{
"id": "22439",
"normalized": [
{
"db_id": "... | [
{
"id": "22437",
"normalized": [
{
"db_id": "D012559",
"db_name": "MESH"
}
],
"offsets": [
[
215,
228
]
],
"text": [
"schizophrenia"
],
"type": "Disease"
},
{
"id": "22438",
"normalized": [
{
"db_... | [
"Yes",
"No"
] | [
"haloperidol",
"H"
] | [
"catalepsy",
"nutritional deficiency"
] | [
{
"id": "22442",
"normalized": [
{
"db_id": "D002375",
"db_name": "MESH"
}
],
"offsets": [
[
672,
681
]
],
"text": [
"catalepsy"
],
"type": "Disease"
},
{
"id": "22451",
"normalized": [
{
"db_id":... | [
{
"id": "22441",
"normalized": [
{
"db_id": "D006220",
"db_name": "MESH"
}
],
"offsets": [
[
652,
663
]
],
"text": [
"haloperidol"
],
"type": "Chemical"
},
{
"id": "22444",
"normalized": [
{
"db_i... | [
true,
false
] |
mToR inhibitors-induced proteinuria: mechanisms, significance, and management. | Massive urinary protein excretion has been observed after conversion from calcineurin inhibitors to mammalian target of rapamycin (mToR) inhibitors, especially sirolimus, in renal transplant recipients with chronic allograft nephropathy. Because proteinuria is a major predictive factor of poor transplantation outcome, ... | [
{
"id": "22459",
"normalized": [
{
"db_id": "D020123",
"db_name": "MESH"
}
],
"offsets": [
[
199,
208
]
],
"text": [
"rapamycin"
],
"type": "Chemical"
},
{
"id": "22460",
"normalized": [
{
"db_id"... | [
{
"id": "22458",
"normalized": [
{
"db_id": "D011507",
"db_name": "MESH"
}
],
"offsets": [
[
24,
35
]
],
"text": [
"proteinuria"
],
"type": "Disease"
},
{
"id": "22461",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
] | [
"rapamycin",
"rapamycin"
] | [
"proteinuria",
"glomerulosclerosis"
] | [
{
"id": "22458",
"normalized": [
{
"db_id": "D011507",
"db_name": "MESH"
}
],
"offsets": [
[
24,
35
]
],
"text": [
"proteinuria"
],
"type": "Disease"
},
{
"id": "22468",
"normalized": [
{
"db_id":... | [
{
"id": "22459",
"normalized": [
{
"db_id": "D020123",
"db_name": "MESH"
}
],
"offsets": [
[
199,
208
]
],
"text": [
"rapamycin"
],
"type": "Chemical"
},
{
"id": "22459",
"normalized": [
{
"db_id"... | [
true,
false
] |
Hypothalamic prolactin receptor messenger ribonucleic acid levels, prolactin signaling, and hyperprolactinemic inhibition of pulsatile luteinizing hormone secretion are dependent on estradiol. | Hyperprolactinemia can reduce fertility and libido. Although central prolactin actions are thought to contribute to this, the mechanisms are poorly understood. We first tested whether chronic hyperprolactinemia inhibited two neuroendocrine parameters necessary for female fertility: pulsatile LH secretion and the estrog... | [
{
"id": "22498",
"normalized": [
{
"db_id": "D012313",
"db_name": "MESH"
}
],
"offsets": [
[
42,
58
]
],
"text": [
"ribonucleic acid"
],
"type": "Chemical"
},
{
"id": "22500",
"normalized": [
{
"d... | [
{
"id": "22499",
"normalized": [
{
"db_id": "D006966",
"db_name": "MESH"
}
],
"offsets": [
[
92,
110
]
],
"text": [
"hyperprolactinemic"
],
"type": "Disease"
},
{
"id": "22501",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"sulpiride",
"steroid"
] | [
"hyperprolactinemic",
"hyperprolactinemic"
] | [
{
"id": "22499",
"normalized": [
{
"db_id": "D006966",
"db_name": "MESH"
}
],
"offsets": [
[
92,
110
]
],
"text": [
"hyperprolactinemic"
],
"type": "Disease"
},
{
"id": "22499",
"normalized": [
{
... | [
{
"id": "22506",
"normalized": [
{
"db_id": "D013469",
"db_name": "MESH"
}
],
"offsets": [
[
596,
605
]
],
"text": [
"sulpiride"
],
"type": "Chemical"
},
{
"id": "22509",
"normalized": [
{
"db_id"... | [
true,
true
] |
Estrogen prevents cholesteryl ester accumulation in macrophages induced by the HIV protease inhibitor ritonavir. | Individuals with HIV can now live long lives with drug therapy that often includes protease inhibitors such as ritonavir. Many patients, however, develop negative long-term side effects such as premature atherosclerosis. We have previously demonstrated that ritonavir treatment increases atherosclerotic lesion formation... | [
{
"id": "22544",
"normalized": [
{
"db_id": "D002788",
"db_name": "MESH"
}
],
"offsets": [
[
18,
35
]
],
"text": [
"cholesteryl ester"
],
"type": "Chemical"
},
{
"id": "22545",
"normalized": [
{
"... | [
{
"id": "22547",
"normalized": [
{
"db_id": "D050197",
"db_name": "MESH"
}
],
"offsets": [
[
307,
332
]
],
"text": [
"premature atherosclerosis"
],
"type": "Disease"
},
{
"id": "22549",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"ritonavir",
"progesterone"
] | [
"premature atherosclerosis",
"premature atherosclerosis"
] | [
{
"id": "22547",
"normalized": [
{
"db_id": "D050197",
"db_name": "MESH"
}
],
"offsets": [
[
307,
332
]
],
"text": [
"premature atherosclerosis"
],
"type": "Disease"
},
{
"id": "22547",
"normalized": [
{
... | [
{
"id": "22545",
"normalized": [
{
"db_id": "D019438",
"db_name": "MESH"
}
],
"offsets": [
[
102,
111
]
],
"text": [
"ritonavir"
],
"type": "Chemical"
},
{
"id": "22556",
"normalized": [
{
"db_id"... | [
true,
false
] |
Upregulation of brain expression of P-glycoprotein in MRP2-deficient TR(-) rats resembles seizure-induced up-regulation of this drug efflux transporter in normal rats. | PURPOSE: The multidrug resistance protein 2 (MRP2) is a drug efflux transporter that is expressed predominantly at the apical domain of hepatocytes but seems also to be expressed at the apical membrane of brain capillary endothelial cells that form the blood-brain barrier (BBB). MRP2 is absent in the transport-deficien... | [
{
"id": "22593",
"normalized": [
{
"db_id": "D010672",
"db_name": "MESH"
}
],
"offsets": [
[
861,
870
]
],
"text": [
"phenytoin"
],
"type": "Chemical"
},
{
"id": "22594",
"normalized": [
{
"db_id"... | [
{
"id": "22592",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
90,
97
]
],
"text": [
"seizure"
],
"type": "Disease"
},
{
"id": "22595",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"pilocarpine",
"pilocarpine"
] | [
"seizure",
"injury to the brain"
] | [
{
"id": "22592",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
90,
97
]
],
"text": [
"seizure"
],
"type": "Disease"
},
{
"id": "22598",
"normalized": [
{
"db_id": "D0... | [
{
"id": "22594",
"normalized": [
{
"db_id": "D010862",
"db_name": "MESH"
}
],
"offsets": [
[
1987,
1998
]
],
"text": [
"pilocarpine"
],
"type": "Chemical"
},
{
"id": "22594",
"normalized": [
{
"db... | [
true,
false
] |
Use of chromosome substitution strains to identify seizure susceptibility loci in mice. | Seizure susceptibility varies among inbred mouse strains. Chromosome substitution strains (CSS), in which a single chromosome from one inbred strain (donor) has been transferred onto a second strain (host) by repeated backcrossing, may be used to identify quantitative trait loci (QTLs) that contribute to seizure suscep... | [
{
"id": "22609",
"normalized": [
{
"db_id": "D010862",
"db_name": "MESH"
}
],
"offsets": [
[
445,
456
]
],
"text": [
"pilocarpine"
],
"type": "Chemical"
},
{
"id": "22613",
"normalized": [
{
"db_i... | [
{
"id": "22606",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
51,
58
]
],
"text": [
"seizure"
],
"type": "Disease"
},
{
"id": "22607",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"pilocarpine",
"pilocarpine"
] | [
"temporal lobe epilepsy",
"seizure"
] | [
{
"id": "22611",
"normalized": [
{
"db_id": "D004833",
"db_name": "MESH"
}
],
"offsets": [
[
486,
508
]
],
"text": [
"temporal lobe epilepsy"
],
"type": "Disease"
},
{
"id": "22606",
"normalized": [
{
... | [
{
"id": "22609",
"normalized": [
{
"db_id": "D010862",
"db_name": "MESH"
}
],
"offsets": [
[
445,
456
]
],
"text": [
"pilocarpine"
],
"type": "Chemical"
},
{
"id": "22609",
"normalized": [
{
"db_i... | [
true,
true
] |
Investigation of mitochondrial involvement in the experimental model of epilepsy induced by pilocarpine. | Mitochondrial abnormalities have been associated with several aspects of epileptogenesis, such as energy generation, control of cell death, neurotransmitter synthesis, and free radical (FR) production. Increased production of FRs may cause mtDNA damage leading to decreased activities of oxidative phosphorylation comple... | [
{
"id": "22630",
"normalized": [
{
"db_id": "D010862",
"db_name": "MESH"
}
],
"offsets": [
[
92,
103
]
],
"text": [
"pilocarpine"
],
"type": "Chemical"
},
{
"id": "22634",
"normalized": [
{
"db_id... | [
{
"id": "22629",
"normalized": [
{
"db_id": "D004827",
"db_name": "MESH"
}
],
"offsets": [
[
72,
80
]
],
"text": [
"epilepsy"
],
"type": "Disease"
},
{
"id": "22631",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"pilocarpine",
"pilocarpine"
] | [
"temporal lobe epilepsy",
"status epilepticus"
] | [
{
"id": "22635",
"normalized": [
{
"db_id": "D004833",
"db_name": "MESH"
}
],
"offsets": [
[
762,
784
]
],
"text": [
"temporal lobe epilepsy"
],
"type": "Disease"
},
{
"id": "22633",
"normalized": [
{
... | [
{
"id": "22630",
"normalized": [
{
"db_id": "D010862",
"db_name": "MESH"
}
],
"offsets": [
[
92,
103
]
],
"text": [
"pilocarpine"
],
"type": "Chemical"
},
{
"id": "22630",
"normalized": [
{
"db_id... | [
true,
true
] |
Causes of acute thrombotic microangiopathy in patients receiving kidney transplantation. | OBJECTIVES: Thrombotic microangiopathy is a well-known problem in patients following renal transplantation. In postrenal transplantation, thrombotic microangiopathy is often a reflection of hemolytic uremic syndrome. We aimed to determine the causes of thrombotic microangiopathy in a population of renal transplantation... | [
{
"id": "22649",
"normalized": [
{
"db_id": "D016572",
"db_name": "MESH"
}
],
"offsets": [
[
1095,
1107
]
],
"text": [
"cyclosporine"
],
"type": "Chemical"
},
{
"id": "22650",
"normalized": [
{
"d... | [
{
"id": "22642",
"normalized": [
{
"db_id": "D057049",
"db_name": "MESH"
}
],
"offsets": [
[
16,
42
]
],
"text": [
"thrombotic microangiopathy"
],
"type": "Disease"
},
{
"id": "22643",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"cyclosporine",
"tacrolimus"
] | [
"thrombotic microangiopathy",
"hemolytic uremic syndrome"
] | [
{
"id": "22642",
"normalized": [
{
"db_id": "D057049",
"db_name": "MESH"
}
],
"offsets": [
[
16,
42
]
],
"text": [
"thrombotic microangiopathy"
],
"type": "Disease"
},
{
"id": "22645",
"normalized": [
{
... | [
{
"id": "22649",
"normalized": [
{
"db_id": "D016572",
"db_name": "MESH"
}
],
"offsets": [
[
1095,
1107
]
],
"text": [
"cyclosporine"
],
"type": "Chemical"
},
{
"id": "22651",
"normalized": [
{
"d... | [
true,
false
] |
Severe reversible left ventricular systolic and diastolic dysfunction due to accidental iatrogenic epinephrine overdose. | Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epine... | [
{
"id": "22703",
"normalized": [
{
"db_id": "D004837",
"db_name": "MESH"
}
],
"offsets": [
[
99,
110
]
],
"text": [
"epinephrine"
],
"type": "Chemical"
},
{
"id": "22705",
"normalized": [
{
"db_id... | [
{
"id": "22702",
"normalized": [
{
"db_id": "D018487",
"db_name": "MESH"
}
],
"offsets": [
[
18,
69
]
],
"text": [
"left ventricular systolic and diastolic dysfunction"
],
"type": "Disease"
},
{
"id": "22704",
... | [
"Yes",
"No"
] | [
"epinephrine",
"Catecholamine"
] | [
"myocardial stunning",
"cardiomyopathy"
] | [
{
"id": "22711",
"normalized": [
{
"db_id": "D017682",
"db_name": "MESH"
}
],
"offsets": [
[
458,
477
]
],
"text": [
"myocardial stunning"
],
"type": "Disease"
},
{
"id": "22706",
"normalized": [
{
... | [
{
"id": "22703",
"normalized": [
{
"db_id": "D004837",
"db_name": "MESH"
}
],
"offsets": [
[
99,
110
]
],
"text": [
"epinephrine"
],
"type": "Chemical"
},
{
"id": "22705",
"normalized": [
{
"db_id... | [
true,
true
] |
Urinary bladder cancer in Wegener's granulomatosis: risks and relation to cyclophosphamide. | OBJECTIVE: To assess and characterise the risk of bladder cancer, and its relation to cyclophosphamide, in patients with Wegener's granulomatosis. METHODS: In the population based, nationwide Swedish Inpatient Register a cohort of 1065 patients with Wegener's granulomatosis, 1969-95, was identified. Through linkage wit... | [
{
"id": "22721",
"normalized": [
{
"db_id": "D003520",
"db_name": "MESH"
}
],
"offsets": [
[
74,
90
]
],
"text": [
"cyclophosphamide"
],
"type": "Chemical"
},
{
"id": "22723",
"normalized": [
{
"d... | [
{
"id": "22719",
"normalized": [
{
"db_id": "D001749",
"db_name": "MESH"
}
],
"offsets": [
[
0,
22
]
],
"text": [
"Urinary bladder cancer"
],
"type": "Disease"
},
{
"id": "22720",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"cyclophosphamide",
"cyclophosphamide"
] | [
"Urinary bladder cancer",
"Wegener's granulomatosis"
] | [
{
"id": "22719",
"normalized": [
{
"db_id": "D001749",
"db_name": "MESH"
}
],
"offsets": [
[
0,
22
]
],
"text": [
"Urinary bladder cancer"
],
"type": "Disease"
},
{
"id": "22720",
"normalized": [
{
... | [
{
"id": "22721",
"normalized": [
{
"db_id": "D003520",
"db_name": "MESH"
}
],
"offsets": [
[
74,
90
]
],
"text": [
"cyclophosphamide"
],
"type": "Chemical"
},
{
"id": "22721",
"normalized": [
{
"d... | [
true,
true
] |
L-arginine transport in humans with cortisol-induced hypertension. | A deficient L-arginine-nitric oxide system is implicated in cortisol-induced hypertension. We investigate whether abnormalities in L-arginine uptake contribute to this deficiency. Eight healthy men were recruited. Hydrocortisone acetate (50 mg) was given orally every 6 hours for 24 hours after a 5-day fixed-salt diet (... | [
{
"id": "22807",
"normalized": [
{
"db_id": "D001120",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"L-arginine"
],
"type": "Chemical"
},
{
"id": "22808",
"normalized": [
{
"db_id": ... | [
{
"id": "22809",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
53,
65
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "22813",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"Hydrocortisone acetate",
"L-arginine"
] | [
"hypertension",
"hypertension"
] | [
{
"id": "22809",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
53,
65
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "22809",
"normalized": [
{
"db_id"... | [
{
"id": "22815",
"normalized": [
{
"db_id": "C021650",
"db_name": "MESH"
}
],
"offsets": [
[
281,
303
]
],
"text": [
"Hydrocortisone acetate"
],
"type": "Chemical"
},
{
"id": "22807",
"normalized": [
{
... | [
false,
true
] |
MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients. | Our objective was to investigate brain MR imaging findings and the utility of diffusion-weighted (DW) imaging in organ transplant patients who developed neurologic symptoms during tacrolimus therapy. Brain MR studies, including DW imaging, were prospectively performed in 14 organ transplant patients receiving tacrolimu... | [
{
"id": "22838",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
50,
60
]
],
"text": [
"tacrolimus"
],
"type": "Chemical"
},
{
"id": "22840",
"normalized": [
{
"db_id":... | [
{
"id": "22839",
"normalized": [
{
"db_id": "D020258",
"db_name": "MESH"
}
],
"offsets": [
[
69,
82
]
],
"text": [
"neurotoxicity"
],
"type": "Disease"
},
{
"id": "22842",
"normalized": [
{
"db_id... | [
"Yes",
"No"
] | [
"tacrolimus",
"tacrolimus"
] | [
"white matter abnormalities",
"putaminal hemorrhage"
] | [
{
"id": "22843",
"normalized": [
{
"db_id": "D056784",
"db_name": "MESH"
}
],
"offsets": [
[
741,
767
]
],
"text": [
"white matter abnormalities"
],
"type": "Disease"
},
{
"id": "22844",
"normalized": [
{... | [
{
"id": "22838",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
50,
60
]
],
"text": [
"tacrolimus"
],
"type": "Chemical"
},
{
"id": "22838",
"normalized": [
{
"db_id":... | [
false,
false
] |
Octreotide-induced hypoxemia and pulmonary hypertension in premature neonates. | The authors report 2 cases of premature neonates who had enterocutaneous fistula complicating necrotizing enterocolitis. Pulmonary hypertension developed after administration of a somatostatin analogue, octreotide, to enhance resolution of the fistula. The authors discuss the mechanism of the occurrence of this complic... | [
{
"id": "22860",
"normalized": [
{
"db_id": "D015282",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Octreotide"
],
"type": "Chemical"
},
{
"id": "22866",
"normalized": [
{
"db_id": ... | [
{
"id": "22861",
"normalized": [
{
"db_id": "D000860",
"db_name": "MESH"
}
],
"offsets": [
[
19,
28
]
],
"text": [
"hypoxemia"
],
"type": "Disease"
},
{
"id": "22862",
"normalized": [
{
"db_id": "... | [
"Yes",
"No"
] | [
"Octreotide",
"Octreotide"
] | [
"pulmonary hypertension",
"fistula"
] | [
{
"id": "22862",
"normalized": [
{
"db_id": "D006976",
"db_name": "MESH"
}
],
"offsets": [
[
33,
55
]
],
"text": [
"pulmonary hypertension"
],
"type": "Disease"
},
{
"id": "22863",
"normalized": [
{
... | [
{
"id": "22860",
"normalized": [
{
"db_id": "D015282",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Octreotide"
],
"type": "Chemical"
},
{
"id": "22860",
"normalized": [
{
"db_id": ... | [
true,
true
] |
Sequential observations of exencephaly and subsequent morphological changes by mouse exo utero development system: analysis of the mechanism of transformation from exencephaly to anencephaly. | Anencephaly has been suggested to develop from exencephaly; however, there is little direct experimental evidence to support this, and the mechanism of transformation remains unclear. We examined this theory using the exo utero development system that allows direct and sequential observations of mid- to late-gestation ... | [
{
"id": "22881",
"normalized": [
{
"db_id": "D001374",
"db_name": "MESH"
}
],
"offsets": [
[
566,
579
]
],
"text": [
"5-azacytidine"
],
"type": "Chemical"
}
] | [
{
"id": "22875",
"normalized": [
{
"db_id": "D009436",
"db_name": "MESH"
}
],
"offsets": [
[
27,
38
]
],
"text": [
"exencephaly"
],
"type": "Disease"
},
{
"id": "22876",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
] | [
"5-azacytidine",
"5-azacytidine"
] | [
"anencephaly",
"exencephaly"
] | [
{
"id": "22877",
"normalized": [
{
"db_id": "D000757",
"db_name": "MESH"
}
],
"offsets": [
[
179,
190
]
],
"text": [
"anencephaly"
],
"type": "Disease"
},
{
"id": "22875",
"normalized": [
{
"db_id... | [
{
"id": "22881",
"normalized": [
{
"db_id": "D001374",
"db_name": "MESH"
}
],
"offsets": [
[
566,
579
]
],
"text": [
"5-azacytidine"
],
"type": "Chemical"
},
{
"id": "22881",
"normalized": [
{
"db... | [
false,
true
] |
Acute cocaine-induced seizures: differential sensitivity of six inbred mouse strains. | Mature male and female mice from six inbred stains were tested for susceptibility to behavioral seizures induced by a single injection of cocaine. Cocaine was injected ip over a range of doses (50-100 mg/kg) and behavior was monitored for 20 minutes. Seizure end points included latency to forelimb or hindlimb clonus, l... | [
{
"id": "22909",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
6,
13
]
],
"text": [
"cocaine"
],
"type": "Chemical"
},
{
"id": "22912",
"normalized": [
{
"db_id": "D0... | [
{
"id": "22910",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
22,
30
]
],
"text": [
"seizures"
],
"type": "Disease"
},
{
"id": "22911",
"normalized": [
{
"db_id": "D... | [
"Yes"
] | [
"cocaine"
] | [
"seizures"
] | [
{
"id": "22910",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
22,
30
]
],
"text": [
"seizures"
],
"type": "Disease"
}
] | [
{
"id": "22909",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
6,
13
]
],
"text": [
"cocaine"
],
"type": "Chemical"
}
] | [
true
] |
Microangiopathic hemolytic anemia complicating FK506 (tacrolimus) therapy. | We describe 3 episodes of microangiopathic hemolytic anemia (MAHA) in 2 solid organ recipients under FK506 (tacrolimus) therapy. In both cases, discontinuation of FK506 and treatment with plasma exchange, fresh frozen plasma replacement, corticosteroids, aspirin, and dipyridamole led to resolution of MAHA. In one patie... | [
{
"id": "22954",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
47,
52
]
],
"text": [
"FK506"
],
"type": "Chemical"
},
{
"id": "22955",
"normalized": [
{
"db_id": "D01... | [
{
"id": "22953",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
0,
33
]
],
"text": [
"Microangiopathic hemolytic anemia"
],
"type": "Disease"
},
{
"id": "22956",
"normalized": [
... | [
"Yes",
"No"
] | [
"FK506",
"cyclosporin A"
] | [
"Microangiopathic hemolytic anemia",
"Microangiopathic hemolytic anemia"
] | [
{
"id": "22953",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
0,
33
]
],
"text": [
"Microangiopathic hemolytic anemia"
],
"type": "Disease"
},
{
"id": "22953",
"normalized": [
... | [
{
"id": "22954",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
47,
52
]
],
"text": [
"FK506"
],
"type": "Chemical"
},
{
"id": "22970",
"normalized": [
{
"db_id": "D01... | [
true,
true
] |
Variant ventricular tachycardia in desipramine toxicity. | We report a case of variant ventricular tachycardia induced by desipramine toxicity. Unusual features of the arrhythmia are repetitive group beating, progressive shortening of the R-R interval, progressive widening of the QRS complex with eventual failure of intraventricular conduction, and changes in direction of the ... | [
{
"id": "23033",
"normalized": [
{
"db_id": "D003891",
"db_name": "MESH"
}
],
"offsets": [
[
35,
46
]
],
"text": [
"desipramine"
],
"type": "Chemical"
},
{
"id": "23036",
"normalized": [
{
"db_id"... | [
{
"id": "23032",
"normalized": [
{
"db_id": "D017180",
"db_name": "MESH"
}
],
"offsets": [
[
8,
31
]
],
"text": [
"ventricular tachycardia"
],
"type": "Disease"
},
{
"id": "23034",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"desipramine",
"desipramine"
] | [
"ventricular tachycardia",
"arrhythmia"
] | [
{
"id": "23032",
"normalized": [
{
"db_id": "D017180",
"db_name": "MESH"
}
],
"offsets": [
[
8,
31
]
],
"text": [
"ventricular tachycardia"
],
"type": "Disease"
},
{
"id": "23038",
"normalized": [
{
... | [
{
"id": "23033",
"normalized": [
{
"db_id": "D003891",
"db_name": "MESH"
}
],
"offsets": [
[
35,
46
]
],
"text": [
"desipramine"
],
"type": "Chemical"
},
{
"id": "23033",
"normalized": [
{
"db_id"... | [
true,
false
] |
Desipramine-induced delirium at "subtherapeutic" concentrations: a case report. | An elderly patient treated with low dose Desipramine developed a delirium while her plasma level was in the "subtherapeutic" range. Delirium, which may be induced by tricyclic drug therapy in the elderly, can be caused by tricyclics with low anticholinergic potency. Therapeutic ranges for antidepressants that have been... | [
{
"id": "23052",
"normalized": [
{
"db_id": "D003891",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Desipramine"
],
"type": "Chemical"
},
{
"id": "23054",
"normalized": [
{
"db_id":... | [
{
"id": "23053",
"normalized": [
{
"db_id": "D003693",
"db_name": "MESH"
}
],
"offsets": [
[
20,
28
]
],
"text": [
"delirium"
],
"type": "Disease"
},
{
"id": "23055",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"Desipramine",
"antidepressants"
] | [
"delirium",
"delirium"
] | [
{
"id": "23053",
"normalized": [
{
"db_id": "D003693",
"db_name": "MESH"
}
],
"offsets": [
[
20,
28
]
],
"text": [
"delirium"
],
"type": "Disease"
},
{
"id": "23053",
"normalized": [
{
"db_id": "D... | [
{
"id": "23052",
"normalized": [
{
"db_id": "D003891",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Desipramine"
],
"type": "Chemical"
},
{
"id": "23057",
"normalized": [
{
"db_id":... | [
true,
false
] |
Mouse strain-dependent effect of amantadine on motility and brain biogenic amines. | The effect of amantadine hydrochloride, injected i.p. in 6 increments of 100 mg/kg each over 30 hr, on mouse motility and whole brain content of selected biogenic amines and major metabolites was studied in 4 strains of mice. These were the albino Sprague-Dawley ICR and BALB/C, the black C57BL/6 and the brown CDF-I mou... | [
{
"id": "23067",
"normalized": [
{
"db_id": "D000547",
"db_name": "MESH"
}
],
"offsets": [
[
33,
43
]
],
"text": [
"amantadine"
],
"type": "Chemical"
},
{
"id": "23068",
"normalized": [
{
"db_id":... | [
{
"id": "23073",
"normalized": [
{
"db_id": "D003866",
"db_name": "MESH"
}
],
"offsets": [
[
513,
522
]
],
"text": [
"depressed"
],
"type": "Disease"
},
{
"id": "23077",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
] | [
"amantadine",
"norepinephrine"
] | [
"suppression of motility",
"depressed"
] | [
{
"id": "23077",
"normalized": [
{
"db_id": "D011596",
"db_name": "MESH"
}
],
"offsets": [
[
1147,
1170
]
],
"text": [
"suppression of motility"
],
"type": "Disease"
},
{
"id": "23073",
"normalized": [
{
... | [
{
"id": "23067",
"normalized": [
{
"db_id": "D000547",
"db_name": "MESH"
}
],
"offsets": [
[
33,
43
]
],
"text": [
"amantadine"
],
"type": "Chemical"
},
{
"id": "23087",
"normalized": [
{
"db_id":... | [
true,
false
] |
No enhancement by phenobarbital of the hepatocarcinogenicity of a choline-devoid diet in the rat. | An experiment was performed to test whether inclusion of phenobarbital in a choline-devoid diet would increase the hepatocarcinogenicity of the diet. Groups of 5-week old male Fischer-344 rats were fed for 7-25 months semipurified choline-devoid or choline-supplemented diets, containing or not 0.06% phenobarbital. No h... | [
{
"id": "23117",
"normalized": [
{
"db_id": "D010634",
"db_name": "MESH"
}
],
"offsets": [
[
18,
31
]
],
"text": [
"phenobarbital"
],
"type": "Chemical"
},
{
"id": "23118",
"normalized": [
{
"db_i... | [
{
"id": "23124",
"normalized": [
{
"db_id": "D006528",
"db_name": "MESH"
}
],
"offsets": [
[
450,
475
]
],
"text": [
"hepatocellular carcinomas"
],
"type": "Disease"
},
{
"id": "23126",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"choline",
"phenobarbital"
] | [
"hepatocellular carcinomas",
"hepatocellular carcinomas"
] | [
{
"id": "23124",
"normalized": [
{
"db_id": "D006528",
"db_name": "MESH"
}
],
"offsets": [
[
450,
475
]
],
"text": [
"hepatocellular carcinomas"
],
"type": "Disease"
},
{
"id": "23124",
"normalized": [
{
... | [
{
"id": "23118",
"normalized": [
{
"db_id": "D002794",
"db_name": "MESH"
}
],
"offsets": [
[
66,
73
]
],
"text": [
"choline"
],
"type": "Chemical"
},
{
"id": "23117",
"normalized": [
{
"db_id": "D... | [
true,
true
] |
Effect of direct intracoronary administration of methylergonovine in patients with and without variant angina. | The effects of intracoronary administration of methylergonovine were studied in 21 patients with variant angina and 22 patients with atypical chest pain and in others without angina pectoris (control group). Methylergonovine was administered continuously at a rate of 10 micrograms/min up to 50 micrograms. In all patien... | [
{
"id": "23161",
"normalized": [
{
"db_id": "D008755",
"db_name": "MESH"
}
],
"offsets": [
[
49,
65
]
],
"text": [
"methylergonovine"
],
"type": "Chemical"
},
{
"id": "23163",
"normalized": [
{
"d... | [
{
"id": "23162",
"normalized": [
{
"db_id": "D000788",
"db_name": "MESH"
}
],
"offsets": [
[
95,
109
]
],
"text": [
"variant angina"
],
"type": "Disease"
},
{
"id": "23164",
"normalized": [
{
"db_... | [
"Yes",
"No"
] | [
"methylergonovine",
"methylergonovine"
] | [
"coronary spasm",
"variant angina"
] | [
{
"id": "23169",
"normalized": [
{
"db_id": "D003329",
"db_name": "MESH"
}
],
"offsets": [
[
455,
469
]
],
"text": [
"coronary spasm"
],
"type": "Disease"
},
{
"id": "23162",
"normalized": [
{
"db... | [
{
"id": "23161",
"normalized": [
{
"db_id": "D008755",
"db_name": "MESH"
}
],
"offsets": [
[
49,
65
]
],
"text": [
"methylergonovine"
],
"type": "Chemical"
},
{
"id": "23161",
"normalized": [
{
"d... | [
false,
true
] |
Dobutamine stress echocardiography: a sensitive indicator of diminished myocardial function in asymptomatic doxorubicin-treated long-term survivors of childhood cancer. | Doxorubicin is an effective anticancer chemotherapeutic agent known to cause acute and chronic cardiomyopathy. To develop a more sensitive echocardiographic screening test for cardiac damage due to doxorubicin, a cohort study was performed using dobutamine infusion to differentiate asymptomatic long-term survivors of c... | [
{
"id": "23181",
"normalized": [
{
"db_id": "D004280",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Dobutamine"
],
"type": "Chemical"
},
{
"id": "23182",
"normalized": [
{
"db_id": ... | [
{
"id": "23183",
"normalized": [
{
"db_id": "D009369",
"db_name": "MESH"
}
],
"offsets": [
[
161,
167
]
],
"text": [
"cancer"
],
"type": "Disease"
},
{
"id": "23185",
"normalized": [
{
"db_id": "D... | [
"Yes",
"No"
] | [
"doxorubicin",
"Dobutamine"
] | [
"cardiomyopathy",
"cardiac damage"
] | [
{
"id": "23185",
"normalized": [
{
"db_id": "D009202",
"db_name": "MESH"
}
],
"offsets": [
[
264,
278
]
],
"text": [
"cardiomyopathy"
],
"type": "Disease"
},
{
"id": "23186",
"normalized": [
{
"db... | [
{
"id": "23182",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
108,
119
]
],
"text": [
"doxorubicin"
],
"type": "Chemical"
},
{
"id": "23181",
"normalized": [
{
"db_i... | [
true,
true
] |
Effects of aminophylline on the threshold for initiating ventricular fibrillation during respiratory failure. | Cardiac arrhythmias have frequently been reported in association with respiratory failure. The possible additive role of pharmacologic agents in precipitating cardiac disturbances in patients with respiratory failure has only recently been emphasized. The effects of aminophylline on the ventricular fibrillation thresho... | [
{
"id": "23210",
"normalized": [
{
"db_id": "D000628",
"db_name": "MESH"
}
],
"offsets": [
[
11,
24
]
],
"text": [
"aminophylline"
],
"type": "Chemical"
},
{
"id": "23217",
"normalized": [
{
"db_i... | [
{
"id": "23211",
"normalized": [
{
"db_id": "D014693",
"db_name": "MESH"
}
],
"offsets": [
[
57,
81
]
],
"text": [
"ventricular fibrillation"
],
"type": "Disease"
},
{
"id": "23212",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"aminophylline",
"aminophylline"
] | [
"ventricular fibrillation",
"hypoventilation"
] | [
{
"id": "23211",
"normalized": [
{
"db_id": "D014693",
"db_name": "MESH"
}
],
"offsets": [
[
57,
81
]
],
"text": [
"ventricular fibrillation"
],
"type": "Disease"
},
{
"id": "23228",
"normalized": [
{
... | [
{
"id": "23210",
"normalized": [
{
"db_id": "D000628",
"db_name": "MESH"
}
],
"offsets": [
[
11,
24
]
],
"text": [
"aminophylline"
],
"type": "Chemical"
},
{
"id": "23210",
"normalized": [
{
"db_i... | [
true,
true
] |
Case report: acute unintentional carbachol intoxication. | INTRODUCTION: Intoxications with carbachol, a muscarinic cholinergic receptor agonist are rare. We report an interesting case investigating a (near) fatal poisoning. METHODS: The son of an 84-year-old male discovered a newspaper report stating clinical success with plant extracts in Alzheimer's disease. The mode of act... | [
{
"id": "23262",
"normalized": [
{
"db_id": "D002217",
"db_name": "MESH"
}
],
"offsets": [
[
33,
42
]
],
"text": [
"carbachol"
],
"type": "Chemical"
},
{
"id": "23263",
"normalized": [
{
"db_id": ... | [
{
"id": "23264",
"normalized": [
{
"db_id": "D011041",
"db_name": "MESH"
}
],
"offsets": [
[
212,
221
]
],
"text": [
"poisoning"
],
"type": "Disease"
},
{
"id": "23265",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"carbachol",
"carbachol",
"carbachol",
"carbachol",
"carbachol",
"carbachol",
"carbachol",
"carbachol",
"atropine",
"adrenaline",
"furosemide",
"adrenaline",
"atropine",
"furosemide",
"adrenaline",
"atropine"
] | [
"nausea",
"Bradycardia",
"asystole",
"heart failure",
"hypotension",
"miosis",
"hyperhidrosis",
"hypersalivation",
"bronchospasm",
"poisoning",
"atrio-ventricular dissociation",
"asystole",
"dyspnoea",
"Alzheimer's disease",
"atrio-ventricular dissociation",
"miosis"
] | [
{
"id": "23270",
"normalized": [
{
"db_id": "D009325",
"db_name": "MESH"
}
],
"offsets": [
[
775,
781
]
],
"text": [
"nausea"
],
"type": "Disease"
},
{
"id": "23272",
"normalized": [
{
"db_id": "D... | [
{
"id": "23262",
"normalized": [
{
"db_id": "D002217",
"db_name": "MESH"
}
],
"offsets": [
[
33,
42
]
],
"text": [
"carbachol"
],
"type": "Chemical"
},
{
"id": "23262",
"normalized": [
{
"db_id": ... | [
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false
] |
Crossover comparison of efficacy and preference for rizatriptan 10 mg versus ergotamine/caffeine in migraine. | Rizatriptan is a selective 5-HT(1B/1D) receptor agonist with rapid oral absorption and early onset of action in the acute treatment of migraine. This randomized double- blind crossover outpatient study assessed the preference for 1 rizatriptan 10 mg tablet to 2 ergotamine 1 mg/caffeine 100 mg tablets in 439 patients tr... | [
{
"id": "23370",
"normalized": [
{
"db_id": "C093622",
"db_name": "MESH"
}
],
"offsets": [
[
52,
63
]
],
"text": [
"rizatriptan"
],
"type": "Chemical"
},
{
"id": "23371",
"normalized": [
{
"db_id"... | [
{
"id": "23373",
"normalized": [
{
"db_id": "D008881",
"db_name": "MESH"
}
],
"offsets": [
[
100,
108
]
],
"text": [
"migraine"
],
"type": "Disease"
},
{
"id": "23376",
"normalized": [
{
"db_id": ... | [
"Yes",
"Yes",
"No",
"No"
] | [
"rizatriptan",
"rizatriptan",
"5-HT",
"5-HT"
] | [
"nausea",
"dizziness",
"headache",
"photophobia"
] | [
{
"id": "23409",
"normalized": [
{
"db_id": "D009325",
"db_name": "MESH"
}
],
"offsets": [
[
1559,
1565
]
],
"text": [
"nausea"
],
"type": "Disease"
},
{
"id": "23422",
"normalized": [
{
"db_id": ... | [
{
"id": "23370",
"normalized": [
{
"db_id": "C093622",
"db_name": "MESH"
}
],
"offsets": [
[
52,
63
]
],
"text": [
"rizatriptan"
],
"type": "Chemical"
},
{
"id": "23370",
"normalized": [
{
"db_id"... | [
true,
true,
false,
false
] |
Thrombotic microangiopathy and renal failure associated with antineoplastic chemotherapy. | Five patients with carcinoma developed thrombotic microangiopathy (characterized by renal insufficiency, microangiopathic hemolytic anemia, and usually thrombocytopenia) after treatment with cisplatin, bleomycin, and a vinca alkaloid. One patient had thrombotic thrombocytopenic purpura, three the hemolytic-uremic syndr... | [
{
"id": "23480",
"normalized": [
{
"db_id": "D002945",
"db_name": "MESH"
}
],
"offsets": [
[
281,
290
]
],
"text": [
"cisplatin"
],
"type": "Chemical"
},
{
"id": "23481",
"normalized": [
{
"db_id"... | [
{
"id": "23473",
"normalized": [
{
"db_id": "D057049",
"db_name": "MESH"
}
],
"offsets": [
[
0,
26
]
],
"text": [
"Thrombotic microangiopathy"
],
"type": "Disease"
},
{
"id": "23474",
"normalized": [
{
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"bleomycin",
"vinca alkaloid",
"cisplatin",
"vinca alkaloid",
"cisplatin",
"bleomycin",
"vinca alkaloid",
"cisplatin",
"bleomycin",
"vinca alkaloid",
"bleomycin",
"cisplatin",
"bleomycin",
"bleomycin",
"bleomycin",
"vinca alkaloid",
"vinca alkaloid",
"cisplatin"
] | [
"thrombotic thrombocytopenic purpura",
"hemolytic-uremic syndrome",
"nephrotoxicity",
"nephrotoxicity",
"thrombotic thrombocytopenic purpura",
"hemolytic-uremic syndrome",
"thrombotic thrombocytopenic purpura",
"hemolytic-uremic syndrome",
"nephrotoxicity",
"thrombocytopenia",
"carcinoma",
"an... | [
{
"id": "23483",
"normalized": [
{
"db_id": "D011697",
"db_name": "MESH"
}
],
"offsets": [
[
341,
376
]
],
"text": [
"thrombotic thrombocytopenic purpura"
],
"type": "Disease"
},
{
"id": "23484",
"normalized": ... | [
{
"id": "23481",
"normalized": [
{
"db_id": "D001761",
"db_name": "MESH"
}
],
"offsets": [
[
292,
301
]
],
"text": [
"bleomycin"
],
"type": "Chemical"
},
{
"id": "23482",
"normalized": [
{
"db_id"... | [
false,
false,
true,
false,
false,
false,
false,
false,
false,
true,
true,
true,
false,
false,
true,
false,
false,
true
] |
Salvage therapy with nelarabine, etoposide, and cyclophosphamide in relapsed/refractory paediatric T-cell lymphoblastic leukaemia and lymphoma. | A combination of 5 d of nelarabine (AraG) with 5 d of etoposide (VP) and cyclophosphamide (CPM) and prophylactic intrathecal chemotherapy was used as salvage therapy in seven children with refractory or relapsed T-cell leukaemia or lymphoma. The most common side effects attributable to the AraG included Grade 2 and 3 s... | [
{
"id": "23510",
"normalized": [
{
"db_id": "C104457",
"db_name": "MESH"
}
],
"offsets": [
[
21,
31
]
],
"text": [
"nelarabine"
],
"type": "Chemical"
},
{
"id": "23511",
"normalized": [
{
"db_id":... | [
{
"id": "23513",
"normalized": [
{
"db_id": "D015458",
"db_name": "MESH"
},
{
"db_id": "D016399",
"db_name": "MESH"
}
],
"offsets": [
[
99,
142
]
],
"text": [
"T-cell lymphoblastic leukaemia and lymphom... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"nelarabine",
"nelarabine",
"nelarabine",
"cyclophosphamide",
"etoposide",
"etoposide"
] | [
"neuropathy",
"Haematological toxicity",
"musculoskeletal pain",
"Haematological toxicity",
"Haematological toxicity",
"T-cell lymphoblastic leukaemia and lymphoma"
] | [
{
"id": "23526",
"normalized": [
{
"db_id": "D009422",
"db_name": "MESH"
}
],
"offsets": [
[
481,
491
]
],
"text": [
"neuropathy"
],
"type": "Disease"
},
{
"id": "23528",
"normalized": [
{
"db_id"... | [
{
"id": "23510",
"normalized": [
{
"db_id": "C104457",
"db_name": "MESH"
}
],
"offsets": [
[
21,
31
]
],
"text": [
"nelarabine"
],
"type": "Chemical"
},
{
"id": "23510",
"normalized": [
{
"db_id":... | [
true,
true,
true,
false,
false,
true
] |
The 3-week sulphasalazine syndrome strikes again. | A 34-year-old lady developed a constellation of dermatitis, fever, lymphadenopathy and hepatitis, beginning on the 17th day of a course of oral sulphasalazine for sero-negative rheumatoid arthritis. Cervical and inguinal lymph node biopsies showed the features of severe necrotising lymphadenitis, associated with erythr... | [
{
"id": "23568",
"normalized": [
{
"db_id": "D012460",
"db_name": "MESH"
}
],
"offsets": [
[
11,
25
]
],
"text": [
"sulphasalazine"
],
"type": "Chemical"
},
{
"id": "23573",
"normalized": [
{
"db_... | [
{
"id": "23569",
"normalized": [
{
"db_id": "D003872",
"db_name": "MESH"
}
],
"offsets": [
[
98,
108
]
],
"text": [
"dermatitis"
],
"type": "Disease"
},
{
"id": "23570",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine",
"sulphasalazine"
] | [
"fever",
"myocarditis",
"lymphadenopathy",
"sepsis",
"nephritis",
"dermatitis",
"hepatitis",
"malignancy",
"multi-organ failure",
"adverse drug reaction",
"massive hepatocellular necrosis",
"lymphadenitis",
"bone marrow necrosis",
"autoimmunity"
] | [
{
"id": "23570",
"normalized": [
{
"db_id": "D005334",
"db_name": "MESH"
}
],
"offsets": [
[
110,
115
]
],
"text": [
"fever"
],
"type": "Disease"
},
{
"id": "23582",
"normalized": [
{
"db_id": "D0... | [
{
"id": "23568",
"normalized": [
{
"db_id": "D012460",
"db_name": "MESH"
}
],
"offsets": [
[
11,
25
]
],
"text": [
"sulphasalazine"
],
"type": "Chemical"
},
{
"id": "23568",
"normalized": [
{
"db_... | [
true,
false,
true,
false,
false,
true,
true,
false,
false,
false,
false,
false,
false,
false
] |
Bupropion (Zyban) toxicity. | Bupropion is a monocyclic antidepressant structurally related to amphetamine. Zyban, a sustained-release formulation of bupropion hydrochloride, was recently released in Ireland, as a smoking cessation aid. In the initial 6 months since it's introduction, 12 overdose cases have been reported to The National Poisons Inf... | [
{
"id": "23623",
"normalized": [
{
"db_id": "D016642",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Bupropion"
],
"type": "Chemical"
},
{
"id": "23624",
"normalized": [
{
"db_id": "D... | [
{
"id": "23625",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
18,
26
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "23631",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No"
] | [
"Bupropion",
"Bupropion",
"Bupropion",
"Bupropion",
"Bupropion",
"diazepam",
"antidepressant",
"amphetamine",
"Bupropion",
"antidepressant"
] | [
"tachycardia",
"convulsions",
"hallucinations",
"cardiac arrhythmias",
"cardiac arrest",
"hallucinations",
"convulsions",
"overdose",
"toxicity",
"neurological"
] | [
{
"id": "23633",
"normalized": [
{
"db_id": "D013610",
"db_name": "MESH"
}
],
"offsets": [
[
433,
444
]
],
"text": [
"tachycardia"
],
"type": "Disease"
},
{
"id": "23635",
"normalized": [
{
"db_id... | [
{
"id": "23623",
"normalized": [
{
"db_id": "D016642",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Bupropion"
],
"type": "Chemical"
},
{
"id": "23623",
"normalized": [
{
"db_id": "D... | [
false,
false,
false,
false,
false,
false,
false,
false,
true,
false
] |
Survey of complications of indocyanine green angiography in Japan. | PURPOSE: We evaluated the safety of indocyanine green for use in fundus angiography. METHODS: We sent a questionnaire concerning complications of indocyanine green to 32 institutions in Japan, which were selected on the basis of the client list from the Topcon Company, which manufactures the indocyanine green fundus ca... | [
{
"id": "23700",
"normalized": [
{
"db_id": "D007208",
"db_name": "MESH"
}
],
"offsets": [
[
27,
44
]
],
"text": [
"indocyanine green"
],
"type": "Chemical"
},
{
"id": "23701",
"normalized": [
{
"... | [
{
"id": "23707",
"normalized": [
{
"db_id": "D009325",
"db_name": "MESH"
}
],
"offsets": [
[
1008,
1014
]
],
"text": [
"nausea"
],
"type": "Disease"
},
{
"id": "23708",
"normalized": [
{
"db_id": ... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"indocyanine green",
"indocyanine green",
"indocyanine green",
"indocyanine green",
"indocyanine green",
"indocyanine green",
"indocyanine green",
"fluorescein sodium",
"fluorescein sodium",
"fluorescein sodium",
"fluorescein sodium",
"fluorescein sodium",
"fluorescein sodium",
"fluorescei... | [
"shock",
"pain",
"hypotension",
"itchiness",
"nausea",
"exanthema",
"urtication",
"hypotension",
"exanthema",
"pain",
"nausea",
"shock",
"urtication",
"itchiness"
] | [
{
"id": "23714",
"normalized": [
{
"db_id": "D012769",
"db_name": "MESH"
}
],
"offsets": [
[
1263,
1268
]
],
"text": [
"shock"
],
"type": "Disease"
},
{
"id": "23711",
"normalized": [
{
"db_id": "... | [
{
"id": "23700",
"normalized": [
{
"db_id": "D007208",
"db_name": "MESH"
}
],
"offsets": [
[
27,
44
]
],
"text": [
"indocyanine green"
],
"type": "Chemical"
},
{
"id": "23700",
"normalized": [
{
"... | [
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false
] |
Bradykinin receptors antagonists and nitric oxide synthase inhibitors in vincristine and streptozotocin induced hyperalgesia in chemotherapy and diabetic neuropathy rat model. | PURPOSE: The influence of an irreversible inhibitor of constitutive NO synthase (L-NOArg; 1.0 mg/kg ip), a relatively selective inhibitor of inducible NO synthase (L-NIL; 1.0 mg/kg ip) and a relatively specific inhibitor of neuronal NO synthase (7-NI; 0.1 mg/kg ip), on antihyperalgesic action of selective antagonists o... | [
{
"id": "23794",
"normalized": [
{
"db_id": "D001920",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Bradykinin"
],
"type": "Chemical"
},
{
"id": "23795",
"normalized": [
{
"db_id": ... | [
{
"id": "23798",
"normalized": [
{
"db_id": "D006930",
"db_name": "MESH"
}
],
"offsets": [
[
112,
124
]
],
"text": [
"hyperalgesia"
],
"type": "Disease"
},
{
"id": "23799",
"normalized": [
{
"db_i... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"streptozotocin",
"streptozotocin",
"streptozotocin",
"vincristine",
"vincristine",
"vincristine",
"nitric oxide",
"Bradykinin",
"Bradykinin",
"des Arg10 HOE 140",
"Bradykinin",
"HOE 140"
] | [
"diabetic neuropathy",
"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy",
"hyperalgesia",
"diabetic (streptozotocin-induced) and toxic (vincristine-induced) neuropathy",
"toxic (vincristine-induced) neuropathy",
"hyperalgesia",
"diabetic (streptozotocin-induced) and toxic (v... | [
{
"id": "23799",
"normalized": [
{
"db_id": "D003929",
"db_name": "MESH"
}
],
"offsets": [
[
145,
164
]
],
"text": [
"diabetic neuropathy"
],
"type": "Disease"
},
{
"id": "23806",
"normalized": [
{
... | [
{
"id": "23797",
"normalized": [
{
"db_id": "D013311",
"db_name": "MESH"
}
],
"offsets": [
[
89,
103
]
],
"text": [
"streptozotocin"
],
"type": "Chemical"
},
{
"id": "23797",
"normalized": [
{
"db... | [
true,
true,
true,
true,
false,
true,
true,
true,
true,
false,
true,
true
] |
Cardiac toxicity observed in association with high-dose cyclophosphamide-based chemotherapy for metastatic breast cancer. | INTRODUCTION: Cyclophosphamide is an alkylating agent given frequently as a component of many conditioning regimens. In high doses, its nonhematological dose-limiting toxicity is cardiomyopathy. STUDY DESIGN: We combined paclitaxel, melphalan and high-dose cyclophosphamide, thiotepa, and carboplatin in a triple sequent... | [
{
"id": "23892",
"normalized": [
{
"db_id": "D003520",
"db_name": "MESH"
}
],
"offsets": [
[
56,
72
]
],
"text": [
"cyclophosphamide"
],
"type": "Chemical"
},
{
"id": "23894",
"normalized": [
{
"d... | [
{
"id": "23891",
"normalized": [
{
"db_id": "D066126",
"db_name": "MESH"
}
],
"offsets": [
[
0,
16
]
],
"text": [
"Cardiac toxicity"
],
"type": "Disease"
},
{
"id": "23893",
"normalized": [
{
"db_... | [
"Yes",
"No"
] | [
"cyclophosphamide",
"melphalan"
] | [
"congestive heart failure",
"Cardiac toxicity"
] | [
{
"id": "23905",
"normalized": [
{
"db_id": "D006333",
"db_name": "MESH"
}
],
"offsets": [
[
746,
770
]
],
"text": [
"congestive heart failure"
],
"type": "Disease"
},
{
"id": "23891",
"normalized": [
{
... | [
{
"id": "23892",
"normalized": [
{
"db_id": "D003520",
"db_name": "MESH"
}
],
"offsets": [
[
56,
72
]
],
"text": [
"cyclophosphamide"
],
"type": "Chemical"
},
{
"id": "23898",
"normalized": [
{
"d... | [
true,
false
] |
Inappropriate use of carbamazepine and vigabatrin in typical absence seizures. | Carbamazepine and vigabatrin are contraindicated in typical absence seizures. Of 18 consecutive referrals of children with resistant typical absences only, eight were erroneously treated with carbamazepine either as monotherapy or as an add-on. Vigabatrin was also used in the treatment of two children. Frequency of abs... | [
{
"id": "23963",
"normalized": [
{
"db_id": "D002220",
"db_name": "MESH"
}
],
"offsets": [
[
21,
34
]
],
"text": [
"carbamazepine"
],
"type": "Chemical"
},
{
"id": "23964",
"normalized": [
{
"db_i... | [
{
"id": "23965",
"normalized": [
{
"db_id": "D004832",
"db_name": "MESH"
}
],
"offsets": [
[
61,
77
]
],
"text": [
"absence seizures"
],
"type": "Disease"
},
{
"id": "23968",
"normalized": [
{
"db... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"carbamazepine",
"carbamazepine",
"vigabatrin",
"sodium valproate",
"lamotrigine",
"ethosuximide"
] | [
"absence seizures",
"myoclonic jerks",
"absence seizures",
"myoclonic jerks",
"myoclonic jerks",
"myoclonic jerks"
] | [
{
"id": "23965",
"normalized": [
{
"db_id": "D004832",
"db_name": "MESH"
}
],
"offsets": [
[
61,
77
]
],
"text": [
"absence seizures"
],
"type": "Disease"
},
{
"id": "23972",
"normalized": [
{
"db... | [
{
"id": "23963",
"normalized": [
{
"db_id": "D002220",
"db_name": "MESH"
}
],
"offsets": [
[
21,
34
]
],
"text": [
"carbamazepine"
],
"type": "Chemical"
},
{
"id": "23963",
"normalized": [
{
"db_i... | [
true,
true,
true,
false,
false,
false
] |
Hemolytic anemia associated with the use of omeprazole. | Omeprazole is the first drug designed to block the final step in the acid secretory process within the parietal cell. It has been shown to be extremely effective in the treatment of peptic ulcer disease, reflux esophagitis, and the Zollinger-Ellison syndrome. Although clinical experience with omeprazole is still limite... | [
{
"id": "24005",
"normalized": [
{
"db_id": "D009853",
"db_name": "MESH"
}
],
"offsets": [
[
44,
54
]
],
"text": [
"omeprazole"
],
"type": "Chemical"
},
{
"id": "24006",
"normalized": [
{
"db_id":... | [
{
"id": "24004",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
0,
16
]
],
"text": [
"Hemolytic anemia"
],
"type": "Disease"
},
{
"id": "24007",
"normalized": [
{
"db_... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"omeprazole",
"omeprazole",
"omeprazole",
"bilirubin",
"bilirubin",
"bilirubin"
] | [
"shortness of breath",
"Hemolytic anemia",
"lethargy",
"Zollinger-Ellison syndrome",
"reflux esophagitis",
"peptic ulcer disease"
] | [
{
"id": "24014",
"normalized": [
{
"db_id": "D004417",
"db_name": "MESH"
}
],
"offsets": [
[
614,
633
]
],
"text": [
"shortness of breath"
],
"type": "Disease"
},
{
"id": "24004",
"normalized": [
{
... | [
{
"id": "24005",
"normalized": [
{
"db_id": "D009853",
"db_name": "MESH"
}
],
"offsets": [
[
44,
54
]
],
"text": [
"omeprazole"
],
"type": "Chemical"
},
{
"id": "24005",
"normalized": [
{
"db_id":... | [
true,
true,
true,
false,
false,
false
] |
The use and toxicity of didanosine (ddI) in HIV antibody-positive individuals intolerant to zidovudine (AZT) | One hundred and fifty-one patients intolerant to zidovudine (AZT) received didanosine (ddI) to a maximum dose of 12.5 mg/kg/day. Patient response was assessed using changes in CD4+ lymphocyte subset count, HIV p24 antigen, weight, and quality of life. Seventy patients developed major opportunistic infections whilst on ... | [
{
"id": "24059",
"normalized": [
{
"db_id": "D016049",
"db_name": "MESH"
}
],
"offsets": [
[
24,
34
]
],
"text": [
"didanosine"
],
"type": "Chemical"
},
{
"id": "24060",
"normalized": [
{
"db_id":... | [
{
"id": "24058",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
12,
20
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "24061",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No"
] | [
"didanosine",
"didanosine",
"didanosine",
"didanosine",
"didanosine",
"zidovudine",
"didanosine",
"didanosine"
] | [
"glucose tolerance curves",
"Peripheral neuropathy",
"diarrhoea",
"pancreatitis",
"diabetes",
"pancreatitis",
"abdominal pain",
"HIV antibody-positive"
] | [
{
"id": "24076",
"normalized": [
{
"db_id": "D018149",
"db_name": "MESH"
}
],
"offsets": [
[
1318,
1342
]
],
"text": [
"glucose tolerance curves"
],
"type": "Disease"
},
{
"id": "24073",
"normalized": [
{... | [
{
"id": "24059",
"normalized": [
{
"db_id": "D016049",
"db_name": "MESH"
}
],
"offsets": [
[
24,
34
]
],
"text": [
"didanosine"
],
"type": "Chemical"
},
{
"id": "24059",
"normalized": [
{
"db_id":... | [
true,
false,
false,
false,
true,
false,
false,
true
] |
Can angiogenesis be a target of treatment for ribavirin associated hemolytic anemia? | BACKGROUND/AIMS: Recently ribavirin has been found to inhibit angiogenesis and a number of angiogenesis inhibitors such as sunitinib and sorafenib have been found to cause acute hemolysis. We aimed to investigate whether there is a relation between hemoglobin, haptoglobin and angiogenesis soluble markers which are modi... | [
{
"id": "24106",
"normalized": [
{
"db_id": "D012254",
"db_name": "MESH"
}
],
"offsets": [
[
46,
55
]
],
"text": [
"ribavirin"
],
"type": "Chemical"
},
{
"id": "24108",
"normalized": [
{
"db_id": ... | [
{
"id": "24107",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
67,
83
]
],
"text": [
"hemolytic anemia"
],
"type": "Disease"
},
{
"id": "24111",
"normalized": [
{
"db... | [
"Yes",
"Yes",
"No",
"No"
] | [
"sorafenib",
"sunitinib",
"pegylated interferon alpha 2a",
"sunitinib"
] | [
"hemolysis",
"hemolysis",
"hemolytic anemia",
"anemia"
] | [
{
"id": "24111",
"normalized": [
{
"db_id": "D006461",
"db_name": "MESH"
}
],
"offsets": [
[
263,
272
]
],
"text": [
"hemolysis"
],
"type": "Disease"
},
{
"id": "24111",
"normalized": [
{
"db_id":... | [
{
"id": "24110",
"normalized": [
{
"db_id": "C471405",
"db_name": "MESH"
}
],
"offsets": [
[
222,
231
]
],
"text": [
"sorafenib"
],
"type": "Chemical"
},
{
"id": "24109",
"normalized": [
{
"db_id"... | [
true,
true,
false,
false
] |
Cocaine causes memory and learning impairments in rats: involvement of nuclear factor kappa B and oxidative stress, and prevention by topiramate. | Different mechanisms have been suggested for cocaine toxicity including an increase in oxidative stress but the association between oxidative status in the brain and cocaine induced-behaviour is poorly understood. Nuclear factor kappa B (NFkappaB) is a sensor of oxidative stress and participates in memory formation tha... | [
{
"id": "24127",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Cocaine"
],
"type": "Chemical"
},
{
"id": "24131",
"normalized": [
{
"db_id": "C05... | [
{
"id": "24128",
"normalized": [
{
"db_id": "D008569",
"db_name": "MESH"
},
{
"db_id": "D007859",
"db_name": "MESH"
}
],
"offsets": [
[
15,
46
]
],
"text": [
"memory and learning impairments"
],
... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"Cocaine",
"Cocaine",
"Cocaine",
"GSH",
"topiramate",
"topiramate"
] | [
"memory and learning impairments",
"learning impairments",
"memory",
"cocaine addiction",
"learning impairments",
"toxicity"
] | [
{
"id": "24128",
"normalized": [
{
"db_id": "D008569",
"db_name": "MESH"
},
{
"db_id": "D007859",
"db_name": "MESH"
}
],
"offsets": [
[
15,
46
]
],
"text": [
"memory and learning impairments"
],
... | [
{
"id": "24127",
"normalized": [
{
"db_id": "D003042",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Cocaine"
],
"type": "Chemical"
},
{
"id": "24127",
"normalized": [
{
"db_id": "D00... | [
true,
true,
true,
false,
true,
false
] |
Antinociceptive and antiamnesic properties of the presynaptic cholinergic amplifier PG-9. | The antinociceptive effect of 3 alpha-tropyl 2-(p-bromophenyl)propionate [(+/-)-PG-9] (10-40 mg kg-1 s.c.; 30-60 mg kg-1 p.o.; 10-30 mg kg-1 i.v.; 10-30 micrograms/mouse i.c.v.) was examined in mice, rats and guinea pigs by use of the hot-plate, abdominal-constriction, tail-flick and paw-pressure tests. (+/-)-PG-9 anti... | [
{
"id": "24178",
"normalized": [
{
"db_id": "C087567",
"db_name": "MESH"
}
],
"offsets": [
[
84,
88
]
],
"text": [
"PG-9"
],
"type": "Chemical"
},
{
"id": "24179",
"normalized": [
{
"db_id": "C087... | [
{
"id": "24200",
"normalized": [
{
"db_id": "D000647",
"db_name": "MESH"
}
],
"offsets": [
[
1366,
1373
]
],
"text": [
"amnesia"
],
"type": "Disease"
},
{
"id": "24204",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"No",
"No"
] | [
"scopolamine",
"dicyclomine",
"R-(alpha)-methylhistamine",
"pirenzepine"
] | [
"amnesia",
"amnesia",
"amnesia",
"amnesia"
] | [
{
"id": "24200",
"normalized": [
{
"db_id": "D000647",
"db_name": "MESH"
}
],
"offsets": [
[
1366,
1373
]
],
"text": [
"amnesia"
],
"type": "Disease"
},
{
"id": "24200",
"normalized": [
{
"db_id":... | [
{
"id": "24201",
"normalized": [
{
"db_id": "D012601",
"db_name": "MESH"
}
],
"offsets": [
[
1385,
1396
]
],
"text": [
"scopolamine"
],
"type": "Chemical"
},
{
"id": "24185",
"normalized": [
{
"db... | [
true,
false,
false,
false
] |
Hyperbaric oxygen therapy for control of intractable cyclophosphamide-induced hemorrhagic cystitis. | We report a case of intractable hemorrhagic cystitis due to cyclophosphamide therapy for Wegener's granulomatosis. Conservative treatment, including bladder irrigation with physiological saline and instillation of prostaglandin F2 alpha, failed to totally control hemorrhage. We then used hyperbaric oxygen at an absolut... | [
{
"id": "24217",
"normalized": [
{
"db_id": "D010100",
"db_name": "MESH"
}
],
"offsets": [
[
11,
17
]
],
"text": [
"oxygen"
],
"type": "Chemical"
},
{
"id": "24218",
"normalized": [
{
"db_id": "D0... | [
{
"id": "24219",
"normalized": [
{
"db_id": "D006470",
"db_name": "MESH"
},
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
78,
98
]
],
"text": [
"hemorrhagic cystitis"
],
"type": "D... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No"
] | [
"cyclophosphamide",
"cyclophosphamide",
"cyclophosphamide",
"cyclophosphamide",
"prostaglandin F2 alpha",
"prostaglandin F2 alpha",
"prostaglandin F2 alpha",
"oxygen"
] | [
"hematuria",
"hemorrhagic cystitis",
"cystitis",
"hemorrhagic",
"hemorrhagic",
"hemorrhagic cystitis",
"Wegener's granulomatosis",
"hemorrhagic"
] | [
{
"id": "24231",
"normalized": [
{
"db_id": "D006417",
"db_name": "MESH"
}
],
"offsets": [
[
568,
577
]
],
"text": [
"hematuria"
],
"type": "Disease"
},
{
"id": "24219",
"normalized": [
{
"db_id":... | [
{
"id": "24218",
"normalized": [
{
"db_id": "D003520",
"db_name": "MESH"
}
],
"offsets": [
[
53,
69
]
],
"text": [
"cyclophosphamide"
],
"type": "Chemical"
},
{
"id": "24218",
"normalized": [
{
"d... | [
false,
true,
true,
true,
true,
true,
false,
true
] |
Further studies on effects of irrigation solutions on rat bladders. | Further studies on the effects of certain irrigating fluids on the rat bladder for 18 hours are reported. The results have shown that the degradation product p-choloroaniline is not a significant factor in chlorhexidine-digluconate associated erosive cystitis. A high percentage of kanamycin-colistin and povidone-iodine... | [
{
"id": "24284",
"normalized": [
{
"db_id": "C004658",
"db_name": "MESH"
}
],
"offsets": [
[
226,
242
]
],
"text": [
"p-choloroaniline"
],
"type": "Chemical"
},
{
"id": "24285",
"normalized": [
{
... | [
{
"id": "24286",
"normalized": [
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
319,
327
]
],
"text": [
"cystitis"
],
"type": "Disease"
},
{
"id": "24290",
"normalized": [
{
"db_id": ... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No"
] | [
"chlorhexidine-digluconate",
"colistin",
"kanamycin",
"povidone-iodine",
"Picloxydine",
"p-choloroaniline"
] | [
"cystitis",
"cystitis",
"cystitis",
"cystitis",
"cystitis",
"cystitis"
] | [
{
"id": "24286",
"normalized": [
{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
319,
327
]
],
"text": [
"cystitis"
],
"type": "Disease"
},
{
"id": "24286",
"normalized": [
{
"db_id": ... | [
{
"id": "24285",
"normalized": [
{
"db_id": "C010882",
"db_name": "MESH"
}
],
"offsets": [
[
274,
299
]
],
"text": [
"chlorhexidine-digluconate"
],
"type": "Chemical"
},
{
"id": "24288",
"normalized": [
{... | [
true,
true,
true,
true,
true,
true
] |
Clinical experiences in an open and a double-blind trial. | A total of sixty patients were trated with bromperidol first in open conditions (20 patients), then on a double blind basis (40 patients) with haloperidol as the reference substance. The open study lasted for four weeks; the drug was administrated in the form of 1 mg tablets. The daily dose (initial dose: 1 mg; mean do... | [
{
"id": "24308",
"normalized": [
{
"db_id": "C006820",
"db_name": "MESH"
}
],
"offsets": [
[
101,
112
]
],
"text": [
"bromperidol"
],
"type": "Chemical"
},
{
"id": "24309",
"normalized": [
{
"db_i... | [
{
"id": "24310",
"normalized": [
{
"db_id": "D001480",
"db_name": "MESH"
}
],
"offsets": [
[
665,
700
]
],
"text": [
"extrapyramidal concomitant symptoms"
],
"type": "Disease"
},
{
"id": "24312",
"normalized": ... | [
"Yes",
"Yes",
"No",
"No"
] | [
"haloperidol",
"bromperidol",
"haloperidol",
"bromperidol"
] | [
"extrapyramidal concomitant symptoms",
"extrapyramidal concomitant symptoms",
"psychotic syndromes belonging predominantly to the schizophrenia group",
"psychotic syndromes belonging predominantly to the schizophrenia group"
] | [
{
"id": "24310",
"normalized": [
{
"db_id": "D001480",
"db_name": "MESH"
}
],
"offsets": [
[
665,
700
]
],
"text": [
"extrapyramidal concomitant symptoms"
],
"type": "Disease"
},
{
"id": "24310",
"normalized": ... | [
{
"id": "24309",
"normalized": [
{
"db_id": "D006220",
"db_name": "MESH"
}
],
"offsets": [
[
201,
212
]
],
"text": [
"haloperidol"
],
"type": "Chemical"
},
{
"id": "24308",
"normalized": [
{
"db_i... | [
false,
false,
true,
false
] |
Curcumin ameliorates cognitive dysfunction and oxidative damage in phenobarbitone and carbamazepine administered rats. | The antiepileptic drugs, phenobarbitone and carbamazepine are well known to cause cognitive impairment on chronic use. The increase in free radical generation has been implicated as one of the important mechanisms of cognitive impairment by antiepileptic drugs. Curcumin has shown antioxidant, anti-inflammatory and neur... | [
{
"id": "24321",
"normalized": [
{
"db_id": "D003474",
"db_name": "MESH"
}
],
"offsets": [
[
0,
8
]
],
"text": [
"Curcumin"
],
"type": "Chemical"
},
{
"id": "24323",
"normalized": [
{
"db_id": "D0... | [
{
"id": "24322",
"normalized": [
{
"db_id": "D003072",
"db_name": "MESH"
}
],
"offsets": [
[
21,
42
]
],
"text": [
"cognitive dysfunction"
],
"type": "Disease"
},
{
"id": "24327",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"phenobarbitone",
"carbamazepine",
"Curcumin",
"malondialdehyde"
] | [
"cognitive dysfunction",
"cognitive dysfunction",
"cognitive dysfunction",
"cognitive dysfunction"
] | [
{
"id": "24322",
"normalized": [
{
"db_id": "D003072",
"db_name": "MESH"
}
],
"offsets": [
[
21,
42
]
],
"text": [
"cognitive dysfunction"
],
"type": "Disease"
},
{
"id": "24322",
"normalized": [
{
... | [
{
"id": "24323",
"normalized": [
{
"db_id": "D010634",
"db_name": "MESH"
}
],
"offsets": [
[
67,
81
]
],
"text": [
"phenobarbitone"
],
"type": "Chemical"
},
{
"id": "24324",
"normalized": [
{
"db_... | [
true,
true,
true,
false
] |
Pyrrolidine dithiocarbamate protects the piriform cortex in the pilocarpine status epilepticus model. | Pyrrolidine dithiocarbamate (PDTC) has a dual mechanism of action as an antioxidant and an inhibitor of the transcription factor kappa-beta. Both, production of reactive oxygen species as well as activation of NF-kappaB have been implicated in severe neuronal damage in different sub-regions of the hippocampus as well a... | [
{
"id": "24504",
"normalized": [
{
"db_id": "C020972",
"db_name": "MESH"
}
],
"offsets": [
[
0,
27
]
],
"text": [
"Pyrrolidine dithiocarbamate"
],
"type": "Chemical"
},
{
"id": "24505",
"normalized": [
{
... | [
{
"id": "24506",
"normalized": [
{
"db_id": "D013226",
"db_name": "MESH"
}
],
"offsets": [
[
76,
94
]
],
"text": [
"status epilepticus"
],
"type": "Disease"
},
{
"id": "24510",
"normalized": [
{
"... | [
"Yes",
"Yes",
"No",
"No"
] | [
"pilocarpine",
"pilocarpine",
"Pyrrolidine dithiocarbamate",
"oxygen"
] | [
"status epilepticus",
"neuronal damage",
"status epilepticus",
"seizure"
] | [
{
"id": "24506",
"normalized": [
{
"db_id": "D013226",
"db_name": "MESH"
}
],
"offsets": [
[
76,
94
]
],
"text": [
"status epilepticus"
],
"type": "Disease"
},
{
"id": "24510",
"normalized": [
{
"... | [
{
"id": "24505",
"normalized": [
{
"db_id": "D010862",
"db_name": "MESH"
}
],
"offsets": [
[
64,
75
]
],
"text": [
"pilocarpine"
],
"type": "Chemical"
},
{
"id": "24505",
"normalized": [
{
"db_id"... | [
true,
false,
true,
true
] |
Safety profile of a nicotine lozenge compared with that of nicotine gum in adult smokers with underlying medical conditions: a 12-week, randomized, open-label study. | BACKGROUND: Nicotine polacrilex lozenges deliver 25% to 27% more nicotine compared with equivalent doses of nicotine polacrilex gum. The increased nicotine exposure from the lozenge has raised questions about the relative safety of the lozenge and gum. OBJECTIVE: The objective of this study was to compare the safety pr... | [
{
"id": "24552",
"normalized": [
{
"db_id": "D009538",
"db_name": "MESH"
}
],
"offsets": [
[
20,
28
]
],
"text": [
"nicotine"
],
"type": "Chemical"
},
{
"id": "24553",
"normalized": [
{
"db_id": "... | [
{
"id": "24560",
"normalized": [
{
"db_id": "D006331",
"db_name": "MESH"
}
],
"offsets": [
[
680,
693
]
],
"text": [
"heart disease"
],
"type": "Disease"
},
{
"id": "24561",
"normalized": [
{
"db_... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"nicotine",
"nicotine",
"nicotine",
"nicotine",
"nicotine",
"nicotine"
] | [
"nausea",
"headache",
"hiccups",
"hypertension",
"heart disease",
"diabetes mellitus"
] | [
{
"id": "24568",
"normalized": [
{
"db_id": "D009325",
"db_name": "MESH"
}
],
"offsets": [
[
2051,
2057
]
],
"text": [
"nausea"
],
"type": "Disease"
},
{
"id": "24570",
"normalized": [
{
"db_id": ... | [
{
"id": "24552",
"normalized": [
{
"db_id": "D009538",
"db_name": "MESH"
}
],
"offsets": [
[
20,
28
]
],
"text": [
"nicotine"
],
"type": "Chemical"
},
{
"id": "24552",
"normalized": [
{
"db_id": "... | [
false,
false,
false,
false,
false,
false
] |
Development of levodopa-induced dyskinesias in parkinsonian monkeys may depend upon rate of symptom onset and/or duration of symptoms. | Levodopa-induced dyskinesias (LIDs) present a major problem for the long-term management of Parkinson's disease (PD) patients. Due to the interdependence of risk factors in clinical populations, it is difficult to independently examine factors that may influence the development of LIDs. Using macaque monkeys with diffe... | [
{
"id": "24621",
"normalized": [
{
"db_id": "D007980",
"db_name": "MESH"
}
],
"offsets": [
[
15,
23
]
],
"text": [
"levodopa"
],
"type": "Chemical"
},
{
"id": "24624",
"normalized": [
{
"db_id": "... | [
{
"id": "24622",
"normalized": [
{
"db_id": "D004409",
"db_name": "MESH"
}
],
"offsets": [
[
32,
43
]
],
"text": [
"dyskinesias"
],
"type": "Disease"
},
{
"id": "24623",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"No",
"No"
] | [
"levodopa",
"MPTP",
"levodopa",
"MPTP"
] | [
"dyskinesias",
"parkinsonism",
"parkinsonism",
"dyskinesias"
] | [
{
"id": "24622",
"normalized": [
{
"db_id": "D004409",
"db_name": "MESH"
}
],
"offsets": [
[
32,
43
]
],
"text": [
"dyskinesias"
],
"type": "Disease"
},
{
"id": "24631",
"normalized": [
{
"db_id":... | [
{
"id": "24621",
"normalized": [
{
"db_id": "D007980",
"db_name": "MESH"
}
],
"offsets": [
[
15,
23
]
],
"text": [
"levodopa"
],
"type": "Chemical"
},
{
"id": "24630",
"normalized": [
{
"db_id": "... | [
true,
true,
true,
true
] |
Propylthiouracil-induced perinuclear-staining antineutrophil cytoplasmic autoantibody-positive vasculitis in conjunction with pericarditis. | OBJECTIVE: To describe a case of propylthiouracil-induced vasculitis manifesting with pericarditis. METHODS: We present the first case report of a woman with hyperthyroidism treated with propylthiouracil in whom a syndrome of pericarditis, fever, and glomerulonephritis developed. Serologic testing and immunologic studi... | [
{
"id": "24743",
"normalized": [
{
"db_id": "D011441",
"db_name": "MESH"
}
],
"offsets": [
[
0,
16
]
],
"text": [
"Propylthiouracil"
],
"type": "Chemical"
},
{
"id": "24746",
"normalized": [
{
"db... | [
{
"id": "24744",
"normalized": [
{
"db_id": "D014657",
"db_name": "MESH"
}
],
"offsets": [
[
95,
105
]
],
"text": [
"vasculitis"
],
"type": "Disease"
},
{
"id": "24745",
"normalized": [
{
"db_id":... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"Propylthiouracil",
"Propylthiouracil",
"Propylthiouracil",
"prednisone",
"prednisone",
"prednisone"
] | [
"fever",
"pericarditis",
"glomerulonephritis",
"glomerulonephritis",
"fever",
"Graves' disease"
] | [
{
"id": "24752",
"normalized": [
{
"db_id": "D005334",
"db_name": "MESH"
}
],
"offsets": [
[
380,
385
]
],
"text": [
"fever"
],
"type": "Disease"
},
{
"id": "24745",
"normalized": [
{
"db_id": "D0... | [
{
"id": "24743",
"normalized": [
{
"db_id": "D011441",
"db_name": "MESH"
}
],
"offsets": [
[
0,
16
]
],
"text": [
"Propylthiouracil"
],
"type": "Chemical"
},
{
"id": "24743",
"normalized": [
{
"db... | [
true,
true,
true,
false,
false,
false
] |
Two mouse lines selected for differential sensitivities to beta-carboline-induced seizures are also differentially sensitive to various pharmacological effects of other GABA(A) receptor ligands. | Two mouse lines were selectively bred according to their sensitivity (BS line) or resistance (BR line) to seizures induced by a single i.p. injection of methyl beta-carboline-3-carboxylate (beta-CCM), an inverse agonist of the GABA(A) receptor benzodiazepine site. Our aim was to characterize both lines' sensitivities t... | [
{
"id": "24822",
"normalized": [
{
"db_id": "C036150",
"db_name": "MESH"
}
],
"offsets": [
[
59,
73
]
],
"text": [
"beta-carboline"
],
"type": "Chemical"
},
{
"id": "24824",
"normalized": [
{
"db_... | [
{
"id": "24823",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
82,
90
]
],
"text": [
"seizures"
],
"type": "Disease"
},
{
"id": "24825",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"picrotoxin",
"pentylenetetrazol",
"beta-carboline",
"GABA",
"benzodiazepine",
"diazepam"
] | [
"seizures",
"seizures",
"seizures",
"seizures",
"seizures",
"seizures"
] | [
{
"id": "24823",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
82,
90
]
],
"text": [
"seizures"
],
"type": "Disease"
},
{
"id": "24823",
"normalized": [
{
"db_id": "D... | [
{
"id": "24833",
"normalized": [
{
"db_id": "D010852",
"db_name": "MESH"
}
],
"offsets": [
[
728,
738
]
],
"text": [
"picrotoxin"
],
"type": "Chemical"
},
{
"id": "24834",
"normalized": [
{
"db_id... | [
true,
true,
true,
true,
false,
true
] |
Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: a randomized, controlled, double-blind, crossover, double-dose study. | Pain not responsive to morphine is often problematic. Animal and clinical studies have suggested that N-methyl-D-aspartate (NMDA) antagonists, such as ketamine, may be effective in improving opioid analgesia in difficult pain syndromes, such as neuropathic pain. A slow bolus of subhypnotic doses of ketamine (0.25 mg/kg... | [
{
"id": "24868",
"normalized": [
{
"db_id": "D007649",
"db_name": "MESH"
}
],
"offsets": [
[
32,
40
]
],
"text": [
"ketamine"
],
"type": "Chemical"
},
{
"id": "24870",
"normalized": [
{
"db_id": "... | [
{
"id": "24869",
"normalized": [
{
"db_id": "D009369",
"db_name": "MESH"
}
],
"offsets": [
[
44,
50
]
],
"text": [
"cancer"
],
"type": "Disease"
},
{
"id": "24871",
"normalized": [
{
"db_id": "D01... | [
"Yes",
"No"
] | [
"ketamine",
"N-methyl-D-aspartate"
] | [
"Hallucinations",
"confusion"
] | [
{
"id": "24889",
"normalized": [
{
"db_id": "D006212",
"db_name": "MESH"
}
],
"offsets": [
[
1178,
1192
]
],
"text": [
"Hallucinations"
],
"type": "Disease"
},
{
"id": "24885",
"normalized": [
{
"... | [
{
"id": "24868",
"normalized": [
{
"db_id": "D007649",
"db_name": "MESH"
}
],
"offsets": [
[
32,
40
]
],
"text": [
"ketamine"
],
"type": "Chemical"
},
{
"id": "24873",
"normalized": [
{
"db_id": "... | [
false,
false
] |
Endocrine screening in 1,022 men with erectile dysfunction: clinical significance and cost-effective strategy. | PURPOSE: We reviewed the results of serum testosterone and prolactin determination in 1,022 patients referred because of erectile dysfunction and compared the data with history, results of physical examination, other etiological investigations and effects of endocrine therapy to refine the rules of cost-effective endoc... | [
{
"id": "24912",
"normalized": [
{
"db_id": "D013739",
"db_name": "MESH"
}
],
"offsets": [
[
153,
165
]
],
"text": [
"testosterone"
],
"type": "Chemical"
},
{
"id": "24914",
"normalized": [
{
"db_... | [
{
"id": "24911",
"normalized": [
{
"db_id": "D007172",
"db_name": "MESH"
}
],
"offsets": [
[
38,
58
]
],
"text": [
"erectile dysfunction"
],
"type": "Disease"
},
{
"id": "24913",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"testosterone",
"testosterone"
] | [
"low sexual desire",
"pituitary tumors"
] | [
{
"id": "24916",
"normalized": [
{
"db_id": "D020018",
"db_name": "MESH"
}
],
"offsets": [
[
695,
712
]
],
"text": [
"low sexual desire"
],
"type": "Disease"
},
{
"id": "24928",
"normalized": [
{
... | [
{
"id": "24912",
"normalized": [
{
"db_id": "D013739",
"db_name": "MESH"
}
],
"offsets": [
[
153,
165
]
],
"text": [
"testosterone"
],
"type": "Chemical"
},
{
"id": "24912",
"normalized": [
{
"db_... | [
true,
true
] |
Thiopentone pretreatment for propofol injection pain in ambulatory patients. | This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia. In a randomized, double-blind trial, 90 women were allocated to receive one of three treatments prior to induction of anaesthesia with propofol. Patients in Group C received 2 ml normal saline, Group L, 2 ml, lidocaine 2% (40... | [
{
"id": "25021",
"normalized": [
{
"db_id": "D013874",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Thiopentone"
],
"type": "Chemical"
},
{
"id": "25022",
"normalized": [
{
"db_id":... | [
{
"id": "25023",
"normalized": [
{
"db_id": "D010146",
"db_name": "MESH"
}
],
"offsets": [
[
48,
52
]
],
"text": [
"pain"
],
"type": "Disease"
},
{
"id": "25025",
"normalized": [
{
"db_id": "D0101... | [
"Yes",
"No"
] | [
"propofol",
"lidocaine"
] | [
"pain",
"Loss of consciousness"
] | [
{
"id": "25023",
"normalized": [
{
"db_id": "D010146",
"db_name": "MESH"
}
],
"offsets": [
[
48,
52
]
],
"text": [
"pain"
],
"type": "Disease"
},
{
"id": "25030",
"normalized": [
{
"db_id": "D0144... | [
{
"id": "25022",
"normalized": [
{
"db_id": "D015742",
"db_name": "MESH"
}
],
"offsets": [
[
29,
37
]
],
"text": [
"propofol"
],
"type": "Chemical"
},
{
"id": "25027",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Comparison of i.v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repeated doses of suxamethonium in children. | The effectiveness of administration of glycopyrrolate 5 and 10 micrograms kg-1 and atropine 10 and 20 micrograms kg-1 i.v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for compariso... | [
{
"id": "25064",
"normalized": [
{
"db_id": "D006024",
"db_name": "MESH"
}
],
"offsets": [
[
19,
33
]
],
"text": [
"glycopyrrolate"
],
"type": "Chemical"
},
{
"id": "25065",
"normalized": [
{
"db_... | [
{
"id": "25066",
"normalized": [
{
"db_id": "D001919",
"db_name": "MESH"
}
],
"offsets": [
[
68,
79
]
],
"text": [
"bradycardia"
],
"type": "Disease"
},
{
"id": "25067",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
] | [
"suxamethonium",
"suxamethonium"
] | [
"bradycardia",
"arrhythmias"
] | [
{
"id": "25066",
"normalized": [
{
"db_id": "D001919",
"db_name": "MESH"
}
],
"offsets": [
[
68,
79
]
],
"text": [
"bradycardia"
],
"type": "Disease"
},
{
"id": "25067",
"normalized": [
{
"db_id":... | [
{
"id": "25068",
"normalized": [
{
"db_id": "D013390",
"db_name": "MESH"
}
],
"offsets": [
[
124,
137
]
],
"text": [
"suxamethonium"
],
"type": "Chemical"
},
{
"id": "25068",
"normalized": [
{
"db... | [
true,
true
] |
Reduction in caffeine toxicity by acetaminophen. | A patient who allegedly consumed 100 tablets of an over-the-counter analgesic containing sodium acetylsalicylate, caffeine, and acetaminophen displayed no significant CNS stimulation despite the presence of 175 micrograms of caffeine per mL of serum. Because salicylates have been reported to augment the stimulatory eff... | [
{
"id": "25096",
"normalized": [
{
"db_id": "D002110",
"db_name": "MESH"
}
],
"offsets": [
[
13,
21
]
],
"text": [
"caffeine"
],
"type": "Chemical"
},
{
"id": "25098",
"normalized": [
{
"db_id": "... | [
{
"id": "25097",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
22,
30
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "25105",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes",
"No",
"No"
] | [
"caffeine",
"pentylenetetrezol",
"acetaminophen",
"ATP"
] | [
"convulsions",
"convulsions",
"toxicity",
"toxicity"
] | [
{
"id": "25109",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
721,
732
]
],
"text": [
"convulsions"
],
"type": "Disease"
},
{
"id": "25109",
"normalized": [
{
"db_id... | [
{
"id": "25096",
"normalized": [
{
"db_id": "D002110",
"db_name": "MESH"
}
],
"offsets": [
[
13,
21
]
],
"text": [
"caffeine"
],
"type": "Chemical"
},
{
"id": "25119",
"normalized": [
{
"db_id": "... | [
true,
true,
true,
false
] |
Flestolol: an ultra-short-acting beta-adrenergic blocking agent. | Flestolol (ACC-9089) is a nonselective, competitive, ultra-short-acting beta-adrenergic blocking agent, without any intrinsic sympathomimetic activity. Flestolol is metabolized by plasma esterases and has an elimination half-life of approximately 6.5 minutes. This agent was well tolerated in healthy volunteers at doses... | [
{
"id": "25172",
"normalized": [
{
"db_id": "C047847",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Flestolol"
],
"type": "Chemical"
},
{
"id": "25173",
"normalized": [
{
"db_id": "C... | [
{
"id": "25181",
"normalized": [
{
"db_id": "D013610",
"db_name": "MESH"
}
],
"offsets": [
[
799,
810
]
],
"text": [
"tachycardia"
],
"type": "Disease"
},
{
"id": "25185",
"normalized": [
{
"db_id... | [
"Yes",
"No"
] | [
"isoproterenol",
"isoproterenol"
] | [
"tachycardia",
"chest pain"
] | [
{
"id": "25181",
"normalized": [
{
"db_id": "D013610",
"db_name": "MESH"
}
],
"offsets": [
[
799,
810
]
],
"text": [
"tachycardia"
],
"type": "Disease"
},
{
"id": "25188",
"normalized": [
{
"db_id... | [
{
"id": "25180",
"normalized": [
{
"db_id": "D007545",
"db_name": "MESH"
}
],
"offsets": [
[
777,
790
]
],
"text": [
"isoproterenol"
],
"type": "Chemical"
},
{
"id": "25180",
"normalized": [
{
"db... | [
true,
false
] |
Adverse effect of the calcium channel blocker nitrendipine on nephrosclerosis in rats with renovascular hypertension. | The effect of a 6-week treatment with the calcium channel blocker nitrendipine or the angiotensin converting enzyme inhibitor enalapril on blood pressure, albuminuria, renal hemodynamics, and morphology of the nonclipped kidney was studied in rats with two-kidney, one clip renovascular hypertension. Six weeks after cli... | [
{
"id": "25195",
"normalized": [
{
"db_id": "D002118",
"db_name": "MESH"
}
],
"offsets": [
[
22,
29
]
],
"text": [
"calcium"
],
"type": "Chemical"
},
{
"id": "25196",
"normalized": [
{
"db_id": "D... | [
{
"id": "25197",
"normalized": [
{
"db_id": "D009400",
"db_name": "MESH"
}
],
"offsets": [
[
62,
77
]
],
"text": [
"nephrosclerosis"
],
"type": "Disease"
},
{
"id": "25198",
"normalized": [
{
"db_... | [
"Yes",
"Yes",
"No",
"No"
] | [
"nitrendipine",
"nitrendipine",
"nitrendipine",
"angiotensin"
] | [
"albuminuria",
"nephrosclerosis",
"renovascular hypertension",
"nephrosclerosis"
] | [
{
"id": "25203",
"normalized": [
{
"db_id": "D000419",
"db_name": "MESH"
}
],
"offsets": [
[
273,
284
]
],
"text": [
"albuminuria"
],
"type": "Disease"
},
{
"id": "25197",
"normalized": [
{
"db_id... | [
{
"id": "25196",
"normalized": [
{
"db_id": "D009568",
"db_name": "MESH"
}
],
"offsets": [
[
46,
58
]
],
"text": [
"nitrendipine"
],
"type": "Chemical"
},
{
"id": "25196",
"normalized": [
{
"db_id... | [
true,
true,
true,
false
] |
Treatment of tinnitus by intratympanic instillation of lignocaine (lidocaine) 2 per cent through ventilation tubes. | Idiopathic subjective tinnitus (IST) is one of the most obscure otological pathologies. This paper presents the results of treating IST by intratympanic instillation of lignocaine (lidocaine) 2 per cent through a grommet, for five weekly courses. Fifty-two patients suffering from intractable tinnitus entered this thera... | [
{
"id": "25247",
"normalized": [
{
"db_id": "D008012",
"db_name": "MESH"
}
],
"offsets": [
[
55,
65
]
],
"text": [
"lignocaine"
],
"type": "Chemical"
},
{
"id": "25248",
"normalized": [
{
"db_id":... | [
{
"id": "25246",
"normalized": [
{
"db_id": "D014012",
"db_name": "MESH"
}
],
"offsets": [
[
13,
21
]
],
"text": [
"tinnitus"
],
"type": "Disease"
},
{
"id": "25249",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes",
"No"
] | [
"lignocaine",
"lignocaine",
"lignocaine"
] | [
"vertigo",
"vomiting",
"tinnitus"
] | [
{
"id": "25257",
"normalized": [
{
"db_id": "D014717",
"db_name": "MESH"
}
],
"offsets": [
[
834,
841
]
],
"text": [
"vertigo"
],
"type": "Disease"
},
{
"id": "25258",
"normalized": [
{
"db_id": "... | [
{
"id": "25247",
"normalized": [
{
"db_id": "D008012",
"db_name": "MESH"
}
],
"offsets": [
[
55,
65
]
],
"text": [
"lignocaine"
],
"type": "Chemical"
},
{
"id": "25247",
"normalized": [
{
"db_id":... | [
false,
false,
true
] |
Perhexiline maleate and peripheral neuropathy. | Peripheral neuropathy has been noted as a complication of therapy with perhexiline maleate, a drug widely used in France (and in clinical trials in the United States) for the prophylactic treatment of angina pectoris. In 24 patients with this complication, the marked slowing of motor nerve conduction velocity and the e... | [
{
"id": "25271",
"normalized": [
{
"db_id": "C023470",
"db_name": "MESH"
}
],
"offsets": [
[
0,
19
]
],
"text": [
"Perhexiline maleate"
],
"type": "Chemical"
},
{
"id": "25274",
"normalized": [
{
... | [
{
"id": "25272",
"normalized": [
{
"db_id": "D010523",
"db_name": "MESH"
}
],
"offsets": [
[
24,
45
]
],
"text": [
"peripheral neuropathy"
],
"type": "Disease"
},
{
"id": "25273",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"Perhexiline maleate",
"Perhexiline maleate",
"Perhexiline maleate",
"Perhexiline maleate"
] | [
"demyelinating disorder",
"peripheral neuropathy",
"neuropathy",
"angina pectoris"
] | [
{
"id": "25276",
"normalized": [
{
"db_id": "D003711",
"db_name": "MESH"
}
],
"offsets": [
[
407,
429
]
],
"text": [
"demyelinating disorder"
],
"type": "Disease"
},
{
"id": "25272",
"normalized": [
{
... | [
{
"id": "25271",
"normalized": [
{
"db_id": "C023470",
"db_name": "MESH"
}
],
"offsets": [
[
0,
19
]
],
"text": [
"Perhexiline maleate"
],
"type": "Chemical"
},
{
"id": "25271",
"normalized": [
{
... | [
false,
true,
false,
true
] |
Effect of humoral modulators of morphine-induced increase in locomotor activity of mice. | The effect of humoral modulators on the morphine-induced increase in locomotor activity of mice was studied. The subcutaneous administration of 10 mg/kg of morphine-HC1 produced a marked increase in locomotor activity in mice. The morphine-induced hyperactivity was potentiated by scopolamine and attenuated by physostig... | [
{
"id": "25287",
"normalized": [
{
"db_id": "D009020",
"db_name": "MESH"
}
],
"offsets": [
[
32,
40
]
],
"text": [
"morphine"
],
"type": "Chemical"
},
{
"id": "25289",
"normalized": [
{
"db_id": "... | [
{
"id": "25288",
"normalized": [
{
"db_id": "D006948",
"db_name": "MESH"
}
],
"offsets": [
[
49,
79
]
],
"text": [
"increase in locomotor activity"
],
"type": "Disease"
},
{
"id": "25290",
"normalized": [
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"scopolamine",
"morphine",
"serotonin",
"catecholamines"
] | [
"increase in locomotor activity",
"increase in locomotor activity",
"increase in locomotor activity",
"increase in locomotor activity"
] | [
{
"id": "25288",
"normalized": [
{
"db_id": "D006948",
"db_name": "MESH"
}
],
"offsets": [
[
49,
79
]
],
"text": [
"increase in locomotor activity"
],
"type": "Disease"
},
{
"id": "25288",
"normalized": [
... | [
{
"id": "25295",
"normalized": [
{
"db_id": "D012601",
"db_name": "MESH"
}
],
"offsets": [
[
370,
381
]
],
"text": [
"scopolamine"
],
"type": "Chemical"
},
{
"id": "25287",
"normalized": [
{
"db_i... | [
true,
true,
true,
false
] |
Mechanisms of FK 506-induced hypertension in the rat. | -Tacrolimus (FK 506) is a powerful, widely used immunosuppressant. The clinical utility of FK 506 is complicated by substantial hypertension and nephrotoxicity. To clarify the mechanisms of FK 506-induced hypertension, we studied the chronic effects of FK 506 on the synthesis of endothelin-1 (ET-1), the expression of m... | [
{
"id": "25382",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
14,
20
]
],
"text": [
"FK 506"
],
"type": "Chemical"
},
{
"id": "25384",
"normalized": [
{
"db_id": "D0... | [
{
"id": "25383",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
29,
41
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "25387",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"FK 506",
"FR 139317"
] | [
"hypertension",
"nephrotoxicity"
] | [
{
"id": "25383",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
29,
41
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "25388",
"normalized": [
{
"db_id"... | [
{
"id": "25382",
"normalized": [
{
"db_id": "D016559",
"db_name": "MESH"
}
],
"offsets": [
[
14,
20
]
],
"text": [
"FK 506"
],
"type": "Chemical"
},
{
"id": "25393",
"normalized": [
{
"db_id": "C0... | [
true,
false
] |
Suxamethonium induced prolonged apnea in a patient receiving electroconvulsive therapy. | Suxamethonium causes prolonged apnea in patients in whom pseudocholinesterase enzyme gets deactivated by organophosphorus (OP) poisons. Here, we present a similar incident in a severely depressed patient who received electroconvulsive therapy (ECT). Prolonged apnea in our case ensued because the information about suici... | [
{
"id": "25461",
"normalized": [
{
"db_id": "D013390",
"db_name": "MESH"
}
],
"offsets": [
[
0,
13
]
],
"text": [
"Suxamethonium"
],
"type": "Chemical"
},
{
"id": "25463",
"normalized": [
{
"db_id... | [
{
"id": "25462",
"normalized": [
{
"db_id": "D001049",
"db_name": "MESH"
}
],
"offsets": [
[
32,
37
]
],
"text": [
"apnea"
],
"type": "Disease"
},
{
"id": "25464",
"normalized": [
{
"db_id": "D001... | [
"Yes",
"Yes",
"No",
"No"
] | [
"organophosphorus (OP) poisons",
"Suxamethonium",
"organophosphorus (OP) poisons",
"Suxamethonium"
] | [
"apnea",
"apnea",
"depressed",
"depressed"
] | [
{
"id": "25462",
"normalized": [
{
"db_id": "D001049",
"db_name": "MESH"
}
],
"offsets": [
[
32,
37
]
],
"text": [
"apnea"
],
"type": "Disease"
},
{
"id": "25462",
"normalized": [
{
"db_id": "D001... | [
{
"id": "25465",
"normalized": [
{
"db_id": "D009943",
"db_name": "MESH"
}
],
"offsets": [
[
193,
222
]
],
"text": [
"organophosphorus (OP) poisons"
],
"type": "Chemical"
},
{
"id": "25461",
"normalized": [
... | [
true,
true,
false,
false
] |
The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study. | OBJECTIVE: To determine the safety and efficacy of adjunctive bupropion sustained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most effective treatments have yet to be determined. PATIENTS AND METHODS: The randomi... | [
{
"id": "25484",
"normalized": [
{
"db_id": "D016642",
"db_name": "MESH"
}
],
"offsets": [
[
30,
39
]
],
"text": [
"bupropion"
],
"type": "Chemical"
},
{
"id": "25486",
"normalized": [
{
"db_id": ... | [
{
"id": "25485",
"normalized": [
{
"db_id": "D012735",
"db_name": "MESH"
}
],
"offsets": [
[
48,
66
]
],
"text": [
"sexual dysfunction"
],
"type": "Disease"
},
{
"id": "25488",
"normalized": [
{
"... | [
"Yes",
"No"
] | [
"selective serotonin reuptake inhibitor",
"selective serotonin reuptake inhibitor"
] | [
"Erectile Dysfunction",
"sexual dysfunction"
] | [
{
"id": "25496",
"normalized": [
{
"db_id": "D007172",
"db_name": "MESH"
}
],
"offsets": [
[
904,
924
]
],
"text": [
"Erectile Dysfunction"
],
"type": "Disease"
},
{
"id": "25485",
"normalized": [
{
... | [
{
"id": "25486",
"normalized": [
{
"db_id": "D017367",
"db_name": "MESH"
}
],
"offsets": [
[
80,
118
]
],
"text": [
"selective serotonin reuptake inhibitor"
],
"type": "Chemical"
},
{
"id": "25486",
"normalized... | [
false,
true
] |
Lamivudine for the prevention of hepatitis B virus reactivation in hepatitis-B surface antigen (HBSAG) seropositive cancer patients undergoing cytotoxic chemotherapy. | Hepatitis B virus (HBV) is one of the major causes of chronic liver disease worldwide. Cancer patients who are chronic carriers of HBV have a higher hepatic complication rate while receiving cytotoxic chemotherapy (CT) and this has mainly been attributed to HBV reactivation. In this study, cancer patients who have soli... | [
{
"id": "25517",
"normalized": [
{
"db_id": "D019259",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Lamivudine"
],
"type": "Chemical"
},
{
"id": "25519",
"normalized": [
{
"db_id": ... | [
{
"id": "25518",
"normalized": [
{
"db_id": "D006509",
"db_name": "MESH"
}
],
"offsets": [
[
33,
44
]
],
"text": [
"hepatitis B"
],
"type": "Disease"
},
{
"id": "25521",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
] | [
"hepatitis-B surface antigen",
"alanine"
] | [
"hepatitis B",
"hematological malignancies"
] | [
{
"id": "25518",
"normalized": [
{
"db_id": "D006509",
"db_name": "MESH"
}
],
"offsets": [
[
33,
44
]
],
"text": [
"hepatitis B"
],
"type": "Disease"
},
{
"id": "25527",
"normalized": [
{
"db_id":... | [
{
"id": "25519",
"normalized": [
{
"db_id": "D006514",
"db_name": "MESH"
}
],
"offsets": [
[
67,
94
]
],
"text": [
"hepatitis-B surface antigen"
],
"type": "Chemical"
},
{
"id": "25539",
"normalized": [
{... | [
true,
false
] |
Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine administration in rats. | Rg1, as a ginsenoside extracted from Panax ginseng, could ameliorate spatial learning impairment. Previous studies have demonstrated that Rg1 might be a useful agent for the prevention and treatment of the adverse effects of morphine. The aim of this study was to investigate the effect of Rg1 on learning impairment by ... | [
{
"id": "25554",
"normalized": [
{
"db_id": "C035054",
"db_name": "MESH"
}
],
"offsets": [
[
0,
15
]
],
"text": [
"Ginsenoside Rg1"
],
"type": "Chemical"
},
{
"id": "25556",
"normalized": [
{
"db_... | [
{
"id": "25555",
"normalized": [
{
"db_id": "D007859",
"db_name": "MESH"
}
],
"offsets": [
[
29,
51
]
],
"text": [
"impairment of learning"
],
"type": "Disease"
},
{
"id": "25559",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"morphine",
"Ginsenoside Rg1"
] | [
"impairment of learning",
"impairment of learning"
] | [
{
"id": "25555",
"normalized": [
{
"db_id": "D007859",
"db_name": "MESH"
}
],
"offsets": [
[
29,
51
]
],
"text": [
"impairment of learning"
],
"type": "Disease"
},
{
"id": "25555",
"normalized": [
{
... | [
{
"id": "25556",
"normalized": [
{
"db_id": "D009020",
"db_name": "MESH"
}
],
"offsets": [
[
71,
79
]
],
"text": [
"morphine"
],
"type": "Chemical"
},
{
"id": "25554",
"normalized": [
{
"db_id": "... | [
true,
true
] |
A study on the effect of the duration of subcutaneous heparin injection on bruising and pain. | AIM: This study was carried out to determine the effect of injection duration on bruising and pain following the administration of the subcutaneous injection of heparin. BACKGROUND: Although different methods to prevent bruising and pain following the subcutaneous injection of heparin have been widely studied and descr... | [
{
"id": "25619",
"normalized": [
{
"db_id": "D006493",
"db_name": "MESH"
}
],
"offsets": [
[
54,
61
]
],
"text": [
"heparin"
],
"type": "Chemical"
},
{
"id": "25624",
"normalized": [
{
"db_id": "D... | [
{
"id": "25620",
"normalized": [
{
"db_id": "D003288",
"db_name": "MESH"
}
],
"offsets": [
[
75,
83
]
],
"text": [
"bruising"
],
"type": "Disease"
},
{
"id": "25621",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes"
] | [
"heparin",
"heparin"
] | [
"pain",
"bruising"
] | [
{
"id": "25621",
"normalized": [
{
"db_id": "D010146",
"db_name": "MESH"
}
],
"offsets": [
[
88,
92
]
],
"text": [
"pain"
],
"type": "Disease"
},
{
"id": "25620",
"normalized": [
{
"db_id": "D0032... | [
{
"id": "25619",
"normalized": [
{
"db_id": "D006493",
"db_name": "MESH"
}
],
"offsets": [
[
54,
61
]
],
"text": [
"heparin"
],
"type": "Chemical"
},
{
"id": "25619",
"normalized": [
{
"db_id": "D... | [
true,
true
] |
Acute reserpine and subchronic haloperidol treatments change synaptosomal brain glutamate uptake and elicit orofacial dyskinesia in rats. | Reserpine- and haloperidol-induced orofacial dyskinesia are putative animal models of tardive dyskinesia (TD) whose pathophysiology has been related to free radical generation and oxidative stress. In the present study, the authors induced orofacial dyskinesia by acute reserpine and subchronic haloperidol administratio... | [
{
"id": "25792",
"normalized": [
{
"db_id": "D012110",
"db_name": "MESH"
}
],
"offsets": [
[
6,
15
]
],
"text": [
"reserpine"
],
"type": "Chemical"
},
{
"id": "25793",
"normalized": [
{
"db_id": "... | [
{
"id": "25795",
"normalized": [
{
"db_id": "D004409",
"db_name": "MESH"
}
],
"offsets": [
[
108,
128
]
],
"text": [
"orofacial dyskinesia"
],
"type": "Disease"
},
{
"id": "25798",
"normalized": [
{
... | [
"Yes",
"Yes",
"No"
] | [
"haloperidol",
"reserpine",
"glutamate"
] | [
"orofacial dyskinesia",
"orofacial dyskinesia",
"orofacial dyskinesia"
] | [
{
"id": "25795",
"normalized": [
{
"db_id": "D004409",
"db_name": "MESH"
}
],
"offsets": [
[
108,
128
]
],
"text": [
"orofacial dyskinesia"
],
"type": "Disease"
},
{
"id": "25795",
"normalized": [
{
... | [
{
"id": "25793",
"normalized": [
{
"db_id": "D006220",
"db_name": "MESH"
}
],
"offsets": [
[
31,
42
]
],
"text": [
"haloperidol"
],
"type": "Chemical"
},
{
"id": "25792",
"normalized": [
{
"db_id"... | [
true,
true,
true
] |
Acute psychosis due to treatment with phenytoin in a nonepileptic patient. | The development of psychosis related to antiepileptic drug treatment is usually attributed to the interaction between the epileptic brain substratum and the antiepileptic drugs. The case of a nonepileptic patient who developed psychosis following phenytoin treatment for trigeminal neuralgia is described. This case sugg... | [
{
"id": "25877",
"normalized": [
{
"db_id": "D010672",
"db_name": "MESH"
}
],
"offsets": [
[
38,
47
]
],
"text": [
"phenytoin"
],
"type": "Chemical"
},
{
"id": "25881",
"normalized": [
{
"db_id": ... | [
{
"id": "25876",
"normalized": [
{
"db_id": "D011605",
"db_name": "MESH"
}
],
"offsets": [
[
0,
15
]
],
"text": [
"Acute psychosis"
],
"type": "Disease"
},
{
"id": "25878",
"normalized": [
{
"db_i... | [
"Yes",
"No"
] | [
"phenytoin",
"phenytoin"
] | [
"Acute psychosis",
"trigeminal neuralgia"
] | [
{
"id": "25876",
"normalized": [
{
"db_id": "D011605",
"db_name": "MESH"
}
],
"offsets": [
[
0,
15
]
],
"text": [
"Acute psychosis"
],
"type": "Disease"
},
{
"id": "25882",
"normalized": [
{
"db_i... | [
{
"id": "25877",
"normalized": [
{
"db_id": "D010672",
"db_name": "MESH"
}
],
"offsets": [
[
38,
47
]
],
"text": [
"phenytoin"
],
"type": "Chemical"
},
{
"id": "25877",
"normalized": [
{
"db_id": ... | [
true,
true
] |
The effect of treatment with gum Arabic on gentamicin nephrotoxicity in rats: a preliminary study. | In the present work we assessed the effect of treatment of rats with gum Arabic on acute renal failure induced by gentamicin (GM) nephrotoxicity. Rats were treated with the vehicle (2 mL/kg of distilled water and 5% w/v cellulose, 10 days), gum Arabic (2 mL/kg of a 10% w/v aqueous suspension of gum Arabic powder, orall... | [
{
"id": "25902",
"normalized": [
{
"db_id": "D006170",
"db_name": "MESH"
}
],
"offsets": [
[
29,
39
]
],
"text": [
"gum Arabic"
],
"type": "Chemical"
},
{
"id": "25903",
"normalized": [
{
"db_id":... | [
{
"id": "25904",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
54,
68
]
],
"text": [
"nephrotoxicity"
],
"type": "Disease"
},
{
"id": "25906",
"normalized": [
{
"db_i... | [
"Yes",
"Yes",
"No",
"No"
] | [
"gentamicin",
"gum Arabic",
"urea",
"urea"
] | [
"acute renal failure",
"acute renal failure",
"acute renal failure",
"tubular necrosis"
] | [
{
"id": "25906",
"normalized": [
{
"db_id": "D058186",
"db_name": "MESH"
}
],
"offsets": [
[
182,
201
]
],
"text": [
"acute renal failure"
],
"type": "Disease"
},
{
"id": "25906",
"normalized": [
{
... | [
{
"id": "25903",
"normalized": [
{
"db_id": "D005839",
"db_name": "MESH"
}
],
"offsets": [
[
43,
53
]
],
"text": [
"gentamicin"
],
"type": "Chemical"
},
{
"id": "25902",
"normalized": [
{
"db_id":... | [
true,
true,
false,
true
] |
Visual hallucinations associated with zonisamide. | Zonisamide is a broad-spectrum antiepileptic drug used to treat various types of seizures. Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or ... | [
{
"id": "25958",
"normalized": [
{
"db_id": "C022189",
"db_name": "MESH"
}
],
"offsets": [
[
38,
48
]
],
"text": [
"zonisamide"
],
"type": "Chemical"
},
{
"id": "25959",
"normalized": [
{
"db_id":... | [
{
"id": "25957",
"normalized": [
{
"db_id": "D006212",
"db_name": "MESH"
}
],
"offsets": [
[
0,
21
]
],
"text": [
"Visual hallucinations"
],
"type": "Disease"
},
{
"id": "25960",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"zonisamide",
"zonisamide"
] | [
"Visual hallucinations",
"seizures"
] | [
{
"id": "25957",
"normalized": [
{
"db_id": "D006212",
"db_name": "MESH"
}
],
"offsets": [
[
0,
21
]
],
"text": [
"Visual hallucinations"
],
"type": "Disease"
},
{
"id": "25960",
"normalized": [
{
... | [
{
"id": "25958",
"normalized": [
{
"db_id": "C022189",
"db_name": "MESH"
}
],
"offsets": [
[
38,
48
]
],
"text": [
"zonisamide"
],
"type": "Chemical"
},
{
"id": "25958",
"normalized": [
{
"db_id":... | [
true,
true
] |
GLEPP1 receptor tyrosine phosphatase (Ptpro) in rat PAN nephrosis. A marker of acute podocyte injury. | Glomerular epithelial protein 1 (GLEPP1) is a podocyte receptor membrane protein tyrosine phosphatase located on the apical cell membrane of visceral glomerular epithelial cell and foot processes. This receptor plays a role in regulating the structure and function of podocyte foot process. To better understand the util... | [
{
"id": "25997",
"normalized": [
{
"db_id": "D014443",
"db_name": "MESH"
}
],
"offsets": [
[
16,
24
]
],
"text": [
"tyrosine"
],
"type": "Chemical"
},
{
"id": "25998",
"normalized": [
{
"db_id": "... | [
{
"id": "25999",
"normalized": [
{
"db_id": "D009401",
"db_name": "MESH"
}
],
"offsets": [
[
56,
65
]
],
"text": [
"nephrosis"
],
"type": "Disease"
},
{
"id": "26001",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"PAN",
"PAN",
"tyrosine",
"PAN"
] | [
"proteinuria",
"nephrosis",
"proteinuria",
"glomerulosclerosis"
] | [
{
"id": "26007",
"normalized": [
{
"db_id": "D011507",
"db_name": "MESH"
}
],
"offsets": [
[
904,
915
]
],
"text": [
"proteinuria"
],
"type": "Disease"
},
{
"id": "25999",
"normalized": [
{
"db_id... | [
{
"id": "25998",
"normalized": [
{
"db_id": "D011692",
"db_name": "MESH"
}
],
"offsets": [
[
52,
55
]
],
"text": [
"PAN"
],
"type": "Chemical"
},
{
"id": "25998",
"normalized": [
{
"db_id": "D0116... | [
true,
true,
false,
true
] |
Ticlopidine-induced aplastic anemia: report of three Chinese patients and review of the literature. | In this study, three Chinese patients with ticlopidine-induced aplastic anemia were reported and another 13 patients in the English literature were reviewed. We attempted to find underlying similarities, evaluate the risk factors, and identify appropriate treatment for this complication. All but one of the patients wer... | [
{
"id": "26038",
"normalized": [
{
"db_id": "D013988",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Ticlopidine"
],
"type": "Chemical"
},
{
"id": "26040",
"normalized": [
{
"db_id":... | [
{
"id": "26039",
"normalized": [
{
"db_id": "D000741",
"db_name": "MESH"
}
],
"offsets": [
[
20,
35
]
],
"text": [
"aplastic anemia"
],
"type": "Disease"
},
{
"id": "26041",
"normalized": [
{
"db_... | [
"Yes",
"Yes",
"No",
"No"
] | [
"Ticlopidine",
"Ticlopidine",
"calcium",
"calcium"
] | [
"aplastic anemia",
"Agranulocytosis",
"aplastic anemia",
"Agranulocytosis"
] | [
{
"id": "26039",
"normalized": [
{
"db_id": "D000741",
"db_name": "MESH"
}
],
"offsets": [
[
20,
35
]
],
"text": [
"aplastic anemia"
],
"type": "Disease"
},
{
"id": "26042",
"normalized": [
{
"db_... | [
{
"id": "26038",
"normalized": [
{
"db_id": "D013988",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Ticlopidine"
],
"type": "Chemical"
},
{
"id": "26038",
"normalized": [
{
"db_id":... | [
true,
true,
false,
false
] |
Facilitation of memory retrieval by pre-test morphine and its state dependency in the step-through type passive avoidance learning test in mice. | Amnesia produced by scopolamine and cycloheximide were reversed by morphine given 30 min before the test trial (pre-test), and pre-test morphine also facilitated the memory retrieval in the animals administered naloxone during the training trial. Similarly, pre-test scopolamine partially reversed the scopolamine-induce... | [
{
"id": "26067",
"normalized": [
{
"db_id": "D009020",
"db_name": "MESH"
}
],
"offsets": [
[
45,
53
]
],
"text": [
"morphine"
],
"type": "Chemical"
},
{
"id": "26069",
"normalized": [
{
"db_id": "... | [
{
"id": "26068",
"normalized": [
{
"db_id": "D000647",
"db_name": "MESH"
}
],
"offsets": [
[
145,
152
]
],
"text": [
"Amnesia"
],
"type": "Disease"
},
{
"id": "26076",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"scopolamine",
"cycloheximide",
"morphine",
"naloxone"
] | [
"Amnesia",
"Amnesia",
"Amnesia",
"Amnesia"
] | [
{
"id": "26068",
"normalized": [
{
"db_id": "D000647",
"db_name": "MESH"
}
],
"offsets": [
[
145,
152
]
],
"text": [
"Amnesia"
],
"type": "Disease"
},
{
"id": "26068",
"normalized": [
{
"db_id": "... | [
{
"id": "26069",
"normalized": [
{
"db_id": "D012601",
"db_name": "MESH"
}
],
"offsets": [
[
165,
176
]
],
"text": [
"scopolamine"
],
"type": "Chemical"
},
{
"id": "26070",
"normalized": [
{
"db_i... | [
true,
true,
true,
true
] |
Test conditions influence the response to a drug challenge in rodents. | These studies were conducted to examine the differential response to a drug challenge under varied experimental test conditions routinely employed to study drug-induced behavioral and neurophysiological responses in rodents. Apomorphine, a nonselective dopamine agonist, was selected due to its biphasic behavioral effec... | [
{
"id": "26103",
"normalized": [
{
"db_id": "D001058",
"db_name": "MESH"
}
],
"offsets": [
[
296,
307
]
],
"text": [
"Apomorphine"
],
"type": "Chemical"
},
{
"id": "26104",
"normalized": [
{
"db_i... | [
{
"id": "26105",
"normalized": [
{
"db_id": "D007035",
"db_name": "MESH"
}
],
"offsets": [
[
417,
428
]
],
"text": [
"hypothermia"
],
"type": "Disease"
},
{
"id": "26109",
"normalized": [
{
"db_id... | [
"Yes",
"Yes",
"No",
"No"
] | [
"Apomorphine",
"Apomorphine",
"dopamine agonist",
"HVA"
] | [
"hypothermia",
"hyperactivity",
"hyperactivity",
"hyperactivity"
] | [
{
"id": "26105",
"normalized": [
{
"db_id": "D007035",
"db_name": "MESH"
}
],
"offsets": [
[
417,
428
]
],
"text": [
"hypothermia"
],
"type": "Disease"
},
{
"id": "26109",
"normalized": [
{
"db_id... | [
{
"id": "26103",
"normalized": [
{
"db_id": "D001058",
"db_name": "MESH"
}
],
"offsets": [
[
296,
307
]
],
"text": [
"Apomorphine"
],
"type": "Chemical"
},
{
"id": "26103",
"normalized": [
{
"db_i... | [
true,
true,
false,
false
] |
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