origin_title stringlengths 27 249 | origin_abstract stringlengths 249 3.46k | chemical_entitiesList listlengths 1 42 | disease_entitiesList listlengths 1 33 | label sequencelengths 1 28 | head_chemical_entName sequencelengths 1 28 | tail_disease_entName sequencelengths 1 28 | tail_entity_dict listlengths 1 28 | head_entity_dict listlengths 1 28 | intra-sentence sequencelengths 1 28 |
|---|---|---|---|---|---|---|---|---|---|
Naloxone reverses the antihypertensive effect of clonidine. | In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg. The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone. Naloxone alone d... | [
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"text": [
"Naloxone"
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"type": "Chemical"
},
{
"id": "4",
"normalized": [
{
"db_id": "D003000",
... | [
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"id": "5",
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{
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93,
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"text": [
"hypertensive"
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"type": "Disease"
},
{
"id": "8",
"normalized": [
{
"db_id": "D007... | [
"Yes",
"No"
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"alpha-methyldopa",
"clonidine"
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"hypotensive",
"hypotensive"
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"id": "8",
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274,
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"hypotensive"
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"id": "8",
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"db_id": "D007... | [
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"id": "9",
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306,
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"text": [
"alpha-methyldopa"
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"type": "Chemical"
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{
"id": "4",
"normalized": [
{
"db_id":... | [
true,
false
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Lidocaine-induced cardiac asystole. | Intravenous administration of a single 50-mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers. The patient had no apparent associated conditions which might have predisposed him to the development of bradyarrhythmias; and, th... | [
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0,
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"text": [
"Lidocaine"
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"type": "Chemical"
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{
"id": "30",
"normalized": [
{
"db_id": "D008012... | [
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"id": "29",
"normalized": [
{
"db_id": "D006323",
"db_name": "MESH"
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18,
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"text": [
"cardiac asystole"
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"type": "Disease"
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{
"id": "31",
"normalized": [
{
"db_id": ... | [
"Yes",
"No"
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"Lidocaine",
"Lidocaine"
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"cardiac asystole",
"depression"
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"id": "29",
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"cardiac asystole"
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"type": "Disease"
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"id": "31",
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"db_id": ... | [
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"id": "28",
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0,
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"Lidocaine"
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"type": "Chemical"
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{
"id": "28",
"normalized": [
{
"db_id": "D008012... | [
true,
true
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Suxamethonium infusion rate and observed fasciculations. A dose-response study. | Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1. The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 mg was exceeded. Six additional patients received a 30-mg i.v. bolus dose. Fasci... | [
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0,
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"text": [
"Suxamethonium"
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"type": "Chemical"
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{
"id": "42",
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{
"db_id": "D0... | [
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"normalized": [
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"db_id": "D005207",
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"offsets": [
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41,
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"text": [
"fasciculations"
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"type": "Disease"
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{
"id": "44",
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{
"db_id": "D... | [
"Yes",
"No"
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"Suxamethonium",
"Suxamethonium"
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"fasciculations",
"tetanic"
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{
"id": "41",
"normalized": [
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"db_id": "D005207",
"db_name": "MESH"
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"offsets": [
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41,
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"text": [
"fasciculations"
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"type": "Disease"
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"id": "44",
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"db_id": "D... | [
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0,
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"type": "Chemical"
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{
"id": "40",
"normalized": [
{
"db_id": "D0... | [
true,
true
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Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine). | Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage. It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neuromuscular block. However, ... | [
{
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"offsets": [
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0,
25
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"text": [
"Galanthamine hydrobromide"
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"type": "Chemical"
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{
"id": "86",
"normalized": [
{
... | [
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"id": "91",
"normalized": [
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"db_id": "D062787",
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315,
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"text": [
"overdosage"
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"type": "Disease"
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] | [
"Yes",
"No"
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"physostigmine"
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"overdosage"
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"id": "91",
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"db_id": "D062787",
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315,
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{
"id": "91",
"normalized": [
{
"db_id": "D06... | [
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"id": "86",
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111,
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"text": [
"scopolamine"
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"type": "Chemical"
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{
"id": "92",
"normalized": [
{
"db_id": "D... | [
true,
false
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Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats. | Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure. Newborn female Wistar rats were fed a lithium-containing diet (50 mmol/kg) for 8 weeks and then r... | [
{
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{
"db_id": "D008094",
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"offsets": [
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54,
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"text": [
"lithium"
],
"type": "Chemical"
},
{
"id": "104",
"normalized": [
{
"db_id": "D0080... | [
{
"id": "103",
"normalized": [
{
"db_id": "D007676",
"db_name": "MESH"
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"offsets": [
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70,
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"text": [
"chronic renal failure"
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"type": "Disease"
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{
"id": "105",
"normalized": [
{
"d... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"lithium",
"lithium",
"lithium",
"lithium",
"creatinine",
"creatinine"
] | [
"hypertension",
"proteinuria",
"chronic renal failure",
"glomerulosclerosis",
"renal failure",
"nephropathy"
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{
"id": "117",
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{
"db_id": "D006973",
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1000,
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"text": [
"hypertension"
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"type": "Disease"
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{
"id": "116",
"normalized": [
{
"db_id"... | [
{
"id": "102",
"normalized": [
{
"db_id": "D008094",
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54,
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"text": [
"lithium"
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"type": "Chemical"
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{
"id": "102",
"normalized": [
{
"db_id": "D0080... | [
true,
true,
true,
true,
true,
false
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Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin. | Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of cyclosporin. Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy... | [
{
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34,
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"text": [
"fusidic acid"
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"type": "Chemical"
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{
"id": "217",
"normalized": [
{
"db_id": "... | [
{
"id": "215",
"normalized": [
{
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"db_name": "MESH"
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"offsets": [
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13,
28
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"text": [
"Crohn's disease"
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"type": "Disease"
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{
"id": "219",
"normalized": [
{
"db_id":... | [
"Yes",
"No"
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"fusidic acid"
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"nausea",
"inflammatory bowel disease"
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{
"id": "224",
"normalized": [
{
"db_id": "D009325",
"db_name": "MESH"
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"offsets": [
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910,
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"text": [
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"type": "Disease"
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{
"id": "228",
"normalized": [
{
"db_id": "D0152... | [
{
"id": "216",
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34,
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"type": "Chemical"
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{
"id": "216",
"normalized": [
{
"db_id": "... | [
false,
true
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Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers. | The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls. Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block. | [
{
"id": "239",
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{
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"offsets": [
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83,
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"text": [
"cocaine"
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"type": "Chemical"
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{
"id": "240",
"normalized": [
{
"db_id": "D0030... | [
{
"id": "238",
"normalized": [
{
"db_id": "D009202",
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33,
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"text": [
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{
"id": "241",
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{
"db_id... | [
"Yes",
"Yes",
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"id": "244",
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334,
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"text": [
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{
"id": "246",
"normalized": [
{
... | [
{
"id": "239",
"normalized": [
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"db_name": "MESH"
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],
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83,
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"cocaine"
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"type": "Chemical"
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{
"id": "239",
"normalized": [
{
"db_id": "D0030... | [
true,
true,
true,
true
] |
Sulpiride-induced tardive dystonia. | Sulpiride is a selective D2-receptor antagonist with antipsychotic and antidepressant properties. Although initially thought to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally. We studied a 37-year-old man who developed persistent segmental d... | [
{
"id": "256",
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{
"db_id": "D013469",
"db_name": "MESH"
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"offsets": [
[
0,
9
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],
"text": [
"Sulpiride"
],
"type": "Chemical"
},
{
"id": "258",
"normalized": [
{
"db_id": "D0134... | [
{
"id": "257",
"normalized": [
{
"db_id": "D004421",
"db_name": "MESH"
}
],
"offsets": [
[
18,
34
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],
"text": [
"tardive dystonia"
],
"type": "Disease"
},
{
"id": "261",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"Sulpiride",
"Sulpiride"
] | [
"tardive dystonia",
"parkinsonism"
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{
"id": "257",
"normalized": [
{
"db_id": "D004421",
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18,
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"tardive dystonia"
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"type": "Disease"
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{
"id": "262",
"normalized": [
{
"db_id"... | [
{
"id": "256",
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{
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"offsets": [
[
0,
9
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"Sulpiride"
],
"type": "Chemical"
},
{
"id": "256",
"normalized": [
{
"db_id": "D0134... | [
true,
true
] |
Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine. | During an 18-month period of study 41 hemodialyzed patients receiving desferrioxamine (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity. 6 patients presented clinical symptoms of visual or auditory toxicity. Moreover, detailed ophthalmologic and audiologic studies d... | [
{
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"normalized": [
{
"db_id": "D003676",
"db_name": "MESH"
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"offsets": [
[
64,
79
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"text": [
"desferrioxamine"
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"type": "Chemical"
},
{
"id": "289",
"normalized": [
{
"db_id"... | [
{
"id": "285",
"normalized": [
{
"db_id": "D014786",
"db_name": "MESH"
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{
"db_id": "D006311",
"db_name": "MESH"
}
],
"offsets": [
[
0,
28
]
],
"text": [
"Ocular and auditory toxicity"
],
"type... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No"
] | [
"desferrioxamine",
"desferrioxamine",
"desferrioxamine",
"desferrioxamine",
"desferrioxamine",
"desferrioxamine"
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"pigmentary retinal deposits",
"Ocular and auditory toxicity",
"Ocular",
"neurosensorial hearing loss",
"toxicity",
"hearing loss"
] | [
{
"id": "297",
"normalized": [
{
"db_id": "D012164",
"db_name": "MESH"
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"offsets": [
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604,
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"text": [
"pigmentary retinal deposits"
],
"type": "Disease"
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{
"id": "285",
"normalized": [
{
... | [
{
"id": "288",
"normalized": [
{
"db_id": "D003676",
"db_name": "MESH"
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"offsets": [
[
64,
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"text": [
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"type": "Chemical"
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{
"id": "288",
"normalized": [
{
"db_id"... | [
false,
true,
true,
false,
true,
true
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Myasthenia gravis presenting as weakness after magnesium administration. | We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia. The serum magnesium concentration was 3.0 mEq/L, which is usually well tolerated. The magnesium was stopped and she recovered over a few days. While she was w... | [
{
"id": "361",
"normalized": [
{
"db_id": "D008274",
"db_name": "MESH"
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"offsets": [
[
47,
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"text": [
"magnesium"
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"type": "Chemical"
},
{
"id": "364",
"normalized": [
{
"db_id": "D00... | [
{
"id": "360",
"normalized": [
{
"db_id": "D009157",
"db_name": "MESH"
}
],
"offsets": [
[
0,
17
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],
"text": [
"Myasthenia gravis"
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"type": "Disease"
},
{
"id": "362",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"magnesium",
"acetylcholine"
] | [
"Myasthenia gravis",
"preeclampsia"
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{
"id": "360",
"normalized": [
{
"db_id": "D009157",
"db_name": "MESH"
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],
"offsets": [
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0,
17
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],
"text": [
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"type": "Disease"
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{
"id": "365",
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{
"db_id"... | [
{
"id": "361",
"normalized": [
{
"db_id": "D008274",
"db_name": "MESH"
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],
"offsets": [
[
47,
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"text": [
"magnesium"
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"type": "Chemical"
},
{
"id": "369",
"normalized": [
{
"db_id": "D00... | [
true,
false
] |
Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide. An experimental study/short communication. | Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of hemorrhagic cystitis. The data demonstrate that CAA after i.v. administration does not contribute... | [
{
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"normalized": [
{
"db_id": "C004656",
"db_name": "MESH"
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],
"offsets": [
[
0,
18
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],
"text": [
"Chloroacetaldehyde"
],
"type": "Chemical"
},
{
"id": "391",
"normalized": [
{
"db_i... | [
{
"id": "396",
"normalized": [
{
"db_id": "D006470",
"db_name": "MESH"
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{
"db_id": "D003556",
"db_name": "MESH"
}
],
"offsets": [
[
375,
395
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],
"text": [
"hemorrhagic cystitis"
],
"type": "D... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"Chloroacetaldehyde",
"Chloroacetaldehyde",
"Chloroacetaldehyde",
"Chloroacetaldehyde",
"ifosfamide",
"mesna"
] | [
"hemorrhagic cystitis",
"cystitis",
"hemorrhagic",
"bladder damage",
"bladder damage",
"hemorrhagic"
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{
"id": "396",
"normalized": [
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{
"db_id": "D003556",
"db_name": "MESH"
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"offsets": [
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375,
395
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],
"text": [
"hemorrhagic cystitis"
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"type": "D... | [
{
"id": "390",
"normalized": [
{
"db_id": "C004656",
"db_name": "MESH"
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],
"offsets": [
[
0,
18
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],
"text": [
"Chloroacetaldehyde"
],
"type": "Chemical"
},
{
"id": "390",
"normalized": [
{
"db_i... | [
true,
true,
true,
false,
false,
false
] |
Source of pain and primitive dysfunction in migraine: an identical site? | Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study. Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group. Subsequently 20 migrain... | [
{
"id": "433",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
156,
169
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "435",
"normalized": [
{
"db_id"... | [
{
"id": "430",
"normalized": [
{
"db_id": "D010146",
"db_name": "MESH"
}
],
"offsets": [
[
10,
14
]
],
"text": [
"pain"
],
"type": "Disease"
},
{
"id": "431",
"normalized": [
{
"db_id": "D008881",... | [
"Yes",
"No"
] | [
"nitroglycerin",
"nitroglycerin"
] | [
"migraine",
"pain"
] | [
{
"id": "431",
"normalized": [
{
"db_id": "D008881",
"db_name": "MESH"
}
],
"offsets": [
[
44,
52
]
],
"text": [
"migraine"
],
"type": "Disease"
},
{
"id": "430",
"normalized": [
{
"db_id": "D0101... | [
{
"id": "433",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
156,
169
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "433",
"normalized": [
{
"db_id"... | [
true,
true
] |
Clotiazepam-induced acute hepatitis. | We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative. Clotiazepam withdrawal was followed by prompt recovery. The administration of several benzodiazepines, chemically related to clot... | [
{
"id": "479",
"normalized": [
{
"db_id": "C084599",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Clotiazepam"
],
"type": "Chemical"
},
{
"id": "483",
"normalized": [
{
"db_id": "C0... | [
{
"id": "480",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
}
],
"offsets": [
[
26,
35
]
],
"text": [
"hepatitis"
],
"type": "Disease"
},
{
"id": "481",
"normalized": [
{
"db_id": "D056... | [
"Yes",
"No"
] | [
"Clotiazepam",
"benzodiazepines"
] | [
"hepatitis",
"extensive hepatocellular necrosis"
] | [
{
"id": "480",
"normalized": [
{
"db_id": "D056486",
"db_name": "MESH"
}
],
"offsets": [
[
26,
35
]
],
"text": [
"hepatitis"
],
"type": "Disease"
},
{
"id": "482",
"normalized": [
{
"db_id": "D047... | [
{
"id": "479",
"normalized": [
{
"db_id": "C084599",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Clotiazepam"
],
"type": "Chemical"
},
{
"id": "486",
"normalized": [
{
"db_id": "D0... | [
true,
false
] |
Arterial hypertension as a complication of prolonged ketoconazole treatment. | Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension. In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet continuous blood pressure monitoring demonstrated hypertension 31 (patient 1) and... | [
{
"id": "528",
"normalized": [
{
"db_id": "D007654",
"db_name": "MESH"
}
],
"offsets": [
[
53,
65
]
],
"text": [
"ketoconazole"
],
"type": "Chemical"
},
{
"id": "530",
"normalized": [
{
"db_id": "... | [
{
"id": "527",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
9,
21
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "529",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"No"
] | [
"ketoconazole",
"deoxycorticosterone"
] | [
"hypertension",
"hypertension"
] | [
{
"id": "527",
"normalized": [
{
"db_id": "D006973",
"db_name": "MESH"
}
],
"offsets": [
[
9,
21
]
],
"text": [
"hypertension"
],
"type": "Disease"
},
{
"id": "527",
"normalized": [
{
"db_id": "D0... | [
{
"id": "528",
"normalized": [
{
"db_id": "D007654",
"db_name": "MESH"
}
],
"offsets": [
[
53,
65
]
],
"text": [
"ketoconazole"
],
"type": "Chemical"
},
{
"id": "535",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat. | Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man. Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (A... | [
{
"id": "561",
"normalized": [
{
"db_id": "D000809",
"db_name": "MESH"
}
],
"offsets": [
[
27,
38
]
],
"text": [
"angiotensin"
],
"type": "Chemical"
},
{
"id": "562",
"normalized": [
{
"db_id": "D... | [
{
"id": "563",
"normalized": [
{
"db_id": "D011665",
"db_name": "MESH"
},
{
"db_id": "D051437",
"db_name": "MESH"
}
],
"offsets": [
[
72,
105
]
],
"text": [
"pulmonary and renal insufficiency"
],
... | [
"Yes",
"No"
] | [
"tranexamic acid",
"prostacyclin"
] | [
"intravascular coagulation",
"pulmonary and renal insufficiency"
] | [
{
"id": "566",
"normalized": [
{
"db_id": "D004211",
"db_name": "MESH"
}
],
"offsets": [
[
113,
138
]
],
"text": [
"intravascular coagulation"
],
"type": "Disease"
},
{
"id": "563",
"normalized": [
{
... | [
{
"id": "568",
"normalized": [
{
"db_id": "D014148",
"db_name": "MESH"
}
],
"offsets": [
[
250,
265
]
],
"text": [
"tranexamic acid"
],
"type": "Chemical"
},
{
"id": "587",
"normalized": [
{
"db_i... | [
true,
false
] |
A randomized comparison of labetalol and nitroprusside for induced hypotension. | In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures. Each patient was subjected to an identical anesthetic protocol and similar drug-induced reductions in mean arterial blood pressure (BP) (5... | [
{
"id": "600",
"normalized": [
{
"db_id": "D007741",
"db_name": "MESH"
}
],
"offsets": [
[
27,
36
]
],
"text": [
"labetalol"
],
"type": "Chemical"
},
{
"id": "601",
"normalized": [
{
"db_id": "D00... | [
{
"id": "602",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
67,
78
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "604",
"normalized": [
{
"db_id": "D0... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"nitroprusside",
"nitroprusside",
"labetalol",
"labetalol",
"PO2",
"labetalol"
] | [
"hypotension",
"increase in heart rate and cardiac output",
"hypotension",
"increase in heart rate and cardiac output",
"hypertension",
"hypertension"
] | [
{
"id": "602",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
67,
78
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "608",
"normalized": [
{
"db_id": "D0... | [
{
"id": "601",
"normalized": [
{
"db_id": "D009599",
"db_name": "MESH"
}
],
"offsets": [
[
41,
54
]
],
"text": [
"nitroprusside"
],
"type": "Chemical"
},
{
"id": "601",
"normalized": [
{
"db_id": ... | [
true,
true,
true,
false,
false,
false
] |
Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations. | Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy. Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies. A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat. In the course of developing this m... | [
{
"id": "654",
"normalized": [
{
"db_id": "D002220",
"db_name": "MESH"
}
],
"offsets": [
[
8,
21
]
],
"text": [
"carbamazepine"
],
"type": "Chemical"
},
{
"id": "656",
"normalized": [
{
"db_id": "... | [
{
"id": "655",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
54,
62
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "663",
"normalized": [
{
"db_id": "D0126... | [
"Yes",
"No"
] | [
"hexafluorodiethyl ether",
"folate"
] | [
"seizures",
"weight gain"
] | [
{
"id": "663",
"normalized": [
{
"db_id": "D012640",
"db_name": "MESH"
}
],
"offsets": [
[
565,
573
]
],
"text": [
"seizures"
],
"type": "Disease"
},
{
"id": "664",
"normalized": [
{
"db_id": "D01... | [
{
"id": "666",
"normalized": [
{
"db_id": "D005481",
"db_name": "MESH"
}
],
"offsets": [
[
621,
644
]
],
"text": [
"hexafluorodiethyl ether"
],
"type": "Chemical"
},
{
"id": "656",
"normalized": [
{
... | [
true,
false
] |
Inhibition of sympathoadrenal activity by atrial natriuretic factor in dogs. | In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor. Mean arterial pressure (as a percentage of control +/- SEM) during ... | [
{
"id": "693",
"normalized": [
{
"db_id": "D012964",
"db_name": "MESH"
}
],
"offsets": [
[
132,
138
]
],
"text": [
"sodium"
],
"type": "Chemical"
},
{
"id": "694",
"normalized": [
{
"db_id": "D009... | [
{
"id": "696",
"normalized": [
{
"db_id": "D013610",
"db_name": "MESH"
}
],
"offsets": [
[
588,
599
]
],
"text": [
"tachycardia"
],
"type": "Disease"
},
{
"id": "698",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"nitroglycerin",
"hydralazine",
"epinephrine",
"hydralazine"
] | [
"hypotension",
"hypotension",
"tachycardia",
"tachycardia"
] | [
{
"id": "698",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
734,
745
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "698",
"normalized": [
{
"db_id": "... | [
{
"id": "700",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
772,
785
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "699",
"normalized": [
{
"db_id"... | [
true,
true,
false,
true
] |
Death from chemotherapy in gestational trophoblastic disease. | Multiple cytotoxic drug administration is the generally accepted treatment of patients with a high-risk stage of choriocarcinoma. Based on this principle a 27-year old woman, classified as being in the high-risk group (Goldstein and Berkowitz score: 11), was treated with multiple cytotoxic drugs. The multiple drug sche... | [
{
"id": "710",
"normalized": [
{
"db_id": "D005047",
"db_name": "MESH"
}
],
"offsets": [
[
399,
408
]
],
"text": [
"Etoposide"
],
"type": "Chemical"
},
{
"id": "711",
"normalized": [
{
"db_id": "D... | [
{
"id": "707",
"normalized": [
{
"db_id": "D003643",
"db_name": "MESH"
}
],
"offsets": [
[
0,
5
]
],
"text": [
"Death"
],
"type": "Disease"
},
{
"id": "708",
"normalized": [
{
"db_id": "D031901",
... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"Etoposide",
"Methotrexate",
"Cyclophosphamide",
"Methotrexate",
"Cyclophosphamide",
"Cisplatin"
] | [
"pulmonary obstruction",
"pulmonary obstruction",
"pulmonary obstruction",
"Death",
"tumor",
"pulmonary obstruction"
] | [
{
"id": "718",
"normalized": [
{
"db_id": "D011655",
"db_name": "MESH"
}
],
"offsets": [
[
701,
722
]
],
"text": [
"pulmonary obstruction"
],
"type": "Disease"
},
{
"id": "718",
"normalized": [
{
... | [
{
"id": "710",
"normalized": [
{
"db_id": "D005047",
"db_name": "MESH"
}
],
"offsets": [
[
399,
408
]
],
"text": [
"Etoposide"
],
"type": "Chemical"
},
{
"id": "711",
"normalized": [
{
"db_id": "D... | [
false,
false,
false,
false,
false,
false
] |
Sexual dysfunction among patients with arthritis. | The relationship of arthritis and sexual dysfunction was investigated among 169 patients with rheumatoid arthritis, osteoarthritis and spondyloarthropathy, 130 of whom were pair-matched to controls. Assessments of marital happiness and depressed mood were also made using the CES-D and the Azrin Marital Happiness Scale ... | [
{
"id": "746",
"normalized": [
{
"db_id": "D008727",
"db_name": "MESH"
}
],
"offsets": [
[
642,
654
]
],
"text": [
"methotrexate"
],
"type": "Chemical"
}
] | [
{
"id": "736",
"normalized": [
{
"db_id": "D012735",
"db_name": "MESH"
}
],
"offsets": [
[
0,
18
]
],
"text": [
"Sexual dysfunction"
],
"type": "Disease"
},
{
"id": "737",
"normalized": [
{
"db_id... | [
"Yes",
"No"
] | [
"methotrexate",
"methotrexate"
] | [
"Impotence",
"Sexual dysfunction"
] | [
{
"id": "745",
"normalized": [
{
"db_id": "D007172",
"db_name": "MESH"
}
],
"offsets": [
[
515,
524
]
],
"text": [
"Impotence"
],
"type": "Disease"
},
{
"id": "736",
"normalized": [
{
"db_id": "D0... | [
{
"id": "746",
"normalized": [
{
"db_id": "D008727",
"db_name": "MESH"
}
],
"offsets": [
[
642,
654
]
],
"text": [
"methotrexate"
],
"type": "Chemical"
},
{
"id": "746",
"normalized": [
{
"db_id":... | [
true,
false
] |
Does paracetamol cause urothelial cancer or renal papillary necrosis? | The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls. The risk of renal papillary necrosis was increased nearly 20-fold by consum... | [
{
"id": "756",
"normalized": [
{
"db_id": "D000082",
"db_name": "MESH"
}
],
"offsets": [
[
5,
16
]
],
"text": [
"paracetamol"
],
"type": "Chemical"
},
{
"id": "764",
"normalized": [
{
"db_id": "D0... | [
{
"id": "757",
"normalized": [
{
"db_id": "D014523",
"db_name": "MESH"
}
],
"offsets": [
[
23,
40
]
],
"text": [
"urothelial cancer"
],
"type": "Disease"
},
{
"id": "758",
"normalized": [
{
"db_id... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No"
] | [
"phenacetin",
"phenacetin",
"phenacetin",
"phenacetin",
"phenacetin",
"phenacetin",
"paracetamol",
"phenacetin",
"paracetamol",
"paracetamol"
] | [
"renal papillary necrosis",
"cancer of the renal pelvis, ureter or bladder",
"cancer of the",
"cancer of the renal pelvis and bladder",
"cancer of the renal pelvis",
"urothelial cancer",
"cancer of the",
"cancers",
"urothelial cancer",
"cancer of the renal pelvis and bladder"
] | [
{
"id": "758",
"normalized": [
{
"db_id": "D007681",
"db_name": "MESH"
}
],
"offsets": [
[
44,
68
]
],
"text": [
"renal papillary necrosis"
],
"type": "Disease"
},
{
"id": "760",
"normalized": [
{
... | [
{
"id": "764",
"normalized": [
{
"db_id": "D010615",
"db_name": "MESH"
}
],
"offsets": [
[
205,
215
]
],
"text": [
"phenacetin"
],
"type": "Chemical"
},
{
"id": "764",
"normalized": [
{
"db_id": "... | [
true,
true,
true,
true,
true,
false,
true,
false,
true,
true
] |
Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait. | A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis. Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH st... | [
{
"id": "803",
"normalized": [
{
"db_id": "D003622",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Dapsone"
],
"type": "Chemical"
},
{
"id": "807",
"normalized": [
{
"db_id": "D003622... | [
{
"id": "804",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
30,
46
]
],
"text": [
"hemolytic anemia"
],
"type": "Disease"
},
{
"id": "805",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"Dapsone",
"Dapsone"
] | [
"hemolytic anemia",
"leprosy"
] | [
{
"id": "804",
"normalized": [
{
"db_id": "D000743",
"db_name": "MESH"
}
],
"offsets": [
[
30,
46
]
],
"text": [
"hemolytic anemia"
],
"type": "Disease"
},
{
"id": "805",
"normalized": [
{
"db_id"... | [
{
"id": "803",
"normalized": [
{
"db_id": "D003622",
"db_name": "MESH"
}
],
"offsets": [
[
0,
7
]
],
"text": [
"Dapsone"
],
"type": "Chemical"
},
{
"id": "803",
"normalized": [
{
"db_id": "D003622... | [
true,
true
] |
Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine. | A 47-year-old patient suffering from coronary artery disease was admitted to the CCU in shock with III. AV block, severe hypotension, and impairment of ventricular function. One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d. and then 100 mg b.i.d.) had been initiated. Two days before... | [
{
"id": "843",
"normalized": [
{
"db_id": "D008790",
"db_name": "MESH"
}
],
"offsets": [
[
98,
108
]
],
"text": [
"metoprolol"
],
"type": "Chemical"
},
{
"id": "844",
"normalized": [
{
"db_id": "D... | [
{
"id": "847",
"normalized": [
{
"db_id": "D003324",
"db_name": "MESH"
}
],
"offsets": [
[
186,
209
]
],
"text": [
"coronary artery disease"
],
"type": "Disease"
},
{
"id": "848",
"normalized": [
{
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"diltiazem",
"diltiazem",
"metoprolol",
"metoprolol",
"diltiazem",
"metoprolol",
"sparteine",
"debrisoquine",
"propafenone",
"diltiazem",
"debrisoquine",
"sparteine"
] | [
"hypotension",
"impairment of ventricular function",
"impairment of ventricular function",
"hypotension",
"AV block",
"AV block",
"shock",
"impairment of ventricular function",
"adverse drug reactions",
"adverse drug reactions",
"shock",
"impairment of ventricular function"
] | [
{
"id": "850",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
270,
281
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "851",
"normalized": [
{
"db_id": "... | [
{
"id": "845",
"normalized": [
{
"db_id": "D004110",
"db_name": "MESH"
}
],
"offsets": [
[
123,
132
]
],
"text": [
"diltiazem"
],
"type": "Chemical"
},
{
"id": "845",
"normalized": [
{
"db_id": "D... | [
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false,
false
] |
Triazolam-induced brief episodes of secondary mania in a depressed patient. | Large doses of triazolam repeatedly induced brief episodes of mania in a depressed elderly woman. Features of organic mental disorder (delirium) were not present. Manic excitement was coincident with the duration of action of triazolam. The possible contribution of the triazolo group to changes in affective status is d... | [
{
"id": "892",
"normalized": [
{
"db_id": "D014229",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Triazolam"
],
"type": "Chemical"
},
{
"id": "895",
"normalized": [
{
"db_id": "D0142... | [
{
"id": "893",
"normalized": [
{
"db_id": "D001714",
"db_name": "MESH"
}
],
"offsets": [
[
46,
51
]
],
"text": [
"mania"
],
"type": "Disease"
},
{
"id": "894",
"normalized": [
{
"db_id": "D003866"... | [
"Yes",
"No"
] | [
"Triazolam",
"Triazolam"
] | [
"mania",
"organic mental disorder"
] | [
{
"id": "893",
"normalized": [
{
"db_id": "D001714",
"db_name": "MESH"
}
],
"offsets": [
[
46,
51
]
],
"text": [
"mania"
],
"type": "Disease"
},
{
"id": "898",
"normalized": [
{
"db_id": "D019965"... | [
{
"id": "892",
"normalized": [
{
"db_id": "D014229",
"db_name": "MESH"
}
],
"offsets": [
[
0,
9
]
],
"text": [
"Triazolam"
],
"type": "Chemical"
},
{
"id": "892",
"normalized": [
{
"db_id": "D0142... | [
true,
false
] |
On the mechanisms of the development of tolerance to the muscular rigidity produced by morphine in rats. | The development of tolerance to the muscular rigidity produced by morphine was studied in rats. Saline-pretreated controls given a test dose of morphine (20 mg/kg i.p.) showed a pronounced rigidity recorded as tonic activity in the electromyogram. Rats treated for 11 days with morphine and withdrawn for 36-40 h showed ... | [
{
"id": "919",
"normalized": [
{
"db_id": "D009020",
"db_name": "MESH"
}
],
"offsets": [
[
87,
95
]
],
"text": [
"morphine"
],
"type": "Chemical"
},
{
"id": "921",
"normalized": [
{
"db_id": "D009... | [
{
"id": "918",
"normalized": [
{
"db_id": "D009127",
"db_name": "MESH"
}
],
"offsets": [
[
57,
74
]
],
"text": [
"muscular rigidity"
],
"type": "Disease"
},
{
"id": "920",
"normalized": [
{
"db_id... | [
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No"
] | [
"haloperidol",
"morphine",
"morphine",
"morphine",
"haloperidol",
"haloperidol"
] | [
"muscular rigidity",
"muscular rigidity",
"hyperkinetic",
"akinetic",
"hyperkinetic",
"akinetic"
] | [
{
"id": "918",
"normalized": [
{
"db_id": "D009127",
"db_name": "MESH"
}
],
"offsets": [
[
57,
74
]
],
"text": [
"muscular rigidity"
],
"type": "Disease"
},
{
"id": "918",
"normalized": [
{
"db_id... | [
{
"id": "932",
"normalized": [
{
"db_id": "D006220",
"db_name": "MESH"
}
],
"offsets": [
[
976,
987
]
],
"text": [
"haloperidol"
],
"type": "Chemical"
},
{
"id": "919",
"normalized": [
{
"db_id": ... | [
true,
true,
false,
true,
false,
false
] |
Compression neuropathy of the radial nerve due to pentazocine-induced fibrous myopathy. | Fibrous myopathy is a common, well-known side effect of repeated pentazocine injection. However, compression neuropathy due to fibrotic muscle affected by pentazocine-induced myopathy has not previously been reported. In a 37-year-old woman with documented pentazocine-induced fibrous myopathy of triceps and deltoid mus... | [
{
"id": "1043",
"normalized": [
{
"db_id": "D010423",
"db_name": "MESH"
}
],
"offsets": [
[
50,
61
]
],
"text": [
"pentazocine"
],
"type": "Chemical"
},
{
"id": "1046",
"normalized": [
{
"db_id": ... | [
{
"id": "1040",
"normalized": [
{
"db_id": "D009408",
"db_name": "MESH"
},
{
"db_id": "D020425",
"db_name": "MESH"
}
],
"offsets": [
[
0,
42
]
],
"text": [
"Compression neuropathy of the radial nerve"
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes"
] | [
"pentazocine",
"pentazocine",
"pentazocine",
"pentazocine",
"pentazocine"
] | [
"fibrous myopathy",
"myopathy",
"Compression neuropathy of the radial nerve",
"neuropathy of the radial nerve",
"Compression neuropathy"
] | [
{
"id": "1044",
"normalized": [
{
"db_id": "D005355",
"db_name": "MESH"
},
{
"db_id": "D009135",
"db_name": "MESH"
}
],
"offsets": [
[
70,
86
]
],
"text": [
"fibrous myopathy"
],
"type": "Diseas... | [
{
"id": "1043",
"normalized": [
{
"db_id": "D010423",
"db_name": "MESH"
}
],
"offsets": [
[
50,
61
]
],
"text": [
"pentazocine"
],
"type": "Chemical"
},
{
"id": "1043",
"normalized": [
{
"db_id": ... | [
true,
true,
true,
true,
true
] |
Recurrent reversible acute renal failure from amphotericin. | A patient with cryptogenic cirrhosis and disseminated sporotrichosis developed acute renal failure immediately following the administration of amphotericin B on four separate occasions. The abruptness of the renal failure and its reversibility within days suggests that there was a functional component to the renal dysf... | [
{
"id": "1113",
"normalized": [
{
"db_id": "D000666",
"db_name": "MESH"
}
],
"offsets": [
[
46,
58
]
],
"text": [
"amphotericin"
],
"type": "Chemical"
},
{
"id": "1117",
"normalized": [
{
"db_id":... | [
{
"id": "1112",
"normalized": [
{
"db_id": "D058186",
"db_name": "MESH"
}
],
"offsets": [
[
21,
40
]
],
"text": [
"acute renal failure"
],
"type": "Disease"
},
{
"id": "1114",
"normalized": [
{
"d... | [
"Yes",
"No"
] | [
"amphotericin",
"amphotericin"
] | [
"acute renal failure",
"renal failure"
] | [
{
"id": "1112",
"normalized": [
{
"db_id": "D058186",
"db_name": "MESH"
}
],
"offsets": [
[
21,
40
]
],
"text": [
"acute renal failure"
],
"type": "Disease"
},
{
"id": "1118",
"normalized": [
{
"d... | [
{
"id": "1113",
"normalized": [
{
"db_id": "D000666",
"db_name": "MESH"
}
],
"offsets": [
[
46,
58
]
],
"text": [
"amphotericin"
],
"type": "Chemical"
},
{
"id": "1113",
"normalized": [
{
"db_id":... | [
true,
false
] |
Pneumonitis with pleural and pericardial effusion and neuropathy during amiodarone therapy. | A patient with sinuatrial disease and implanted pacemaker was treated with amiodarone (maximum dose 1000 mg, maintenance dose 800 mg daily) for 10 months, for control of supraventricular tachyarrhythmias. He developed pneumonitis, pleural and pericardial effusions, and a predominantly proximal motor neuropathy. Immedia... | [
{
"id": "1138",
"normalized": [
{
"db_id": "D000638",
"db_name": "MESH"
}
],
"offsets": [
[
72,
82
]
],
"text": [
"amiodarone"
],
"type": "Chemical"
},
{
"id": "1140",
"normalized": [
{
"db_id": "... | [
{
"id": "1134",
"normalized": [
{
"db_id": "D010996",
"db_name": "MESH"
},
{
"db_id": "D010490",
"db_name": "MESH"
}
],
"offsets": [
[
17,
49
]
],
"text": [
"pleural and pericardial effusion"
],
... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No"
] | [
"amiodarone",
"amiodarone",
"amiodarone",
"amiodarone",
"amiodarone",
"steroid",
"steroid",
"prednisolone",
"steroid",
"prednisolone"
] | [
"pleural and pericardial effusion",
"pericardial effusion",
"proximal motor neuropathy",
"pleural",
"pneumonitis",
"pneumonitis",
"sinuatrial disease",
"sinuatrial disease",
"pleural",
"pericardial effusion"
] | [
{
"id": "1134",
"normalized": [
{
"db_id": "D010996",
"db_name": "MESH"
},
{
"db_id": "D010490",
"db_name": "MESH"
}
],
"offsets": [
[
17,
49
]
],
"text": [
"pleural and pericardial effusion"
],
... | [
{
"id": "1138",
"normalized": [
{
"db_id": "D000638",
"db_name": "MESH"
}
],
"offsets": [
[
72,
82
]
],
"text": [
"amiodarone"
],
"type": "Chemical"
},
{
"id": "1138",
"normalized": [
{
"db_id": "... | [
true,
true,
false,
true,
true,
true,
false,
false,
false,
false
] |
Indomethacin-induced renal insufficiency: recurrence on rechallenge. | We have reported a case of acute oliguric renal failure with hyperkalemia in a patient with cirrhosis, ascites, and cor pulmonale after indomethacin therapy. Prompt restoration of renal function followed drug withdrawal, while re-exposure to a single dose of indomethacin caused recurrence of acute reversible oliguria. ... | [
{
"id": "1211",
"normalized": [
{
"db_id": "D007213",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Indomethacin"
],
"type": "Chemical"
},
{
"id": "1218",
"normalized": [
{
"db_id": ... | [
{
"id": "1212",
"normalized": [
{
"db_id": "D051437",
"db_name": "MESH"
}
],
"offsets": [
[
21,
40
]
],
"text": [
"renal insufficiency"
],
"type": "Disease"
},
{
"id": "1213",
"normalized": [
{
"d... | [
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"Yes",
"No",
"No",
"No",
"No",
"No",
"No"
] | [
"Indomethacin",
"Indomethacin",
"Indomethacin",
"Indomethacin",
"Indomethacin",
"Indomethacin",
"prostaglandins",
"prostaglandins",
"prostaglandins",
"prostaglandins",
"Indomethacin",
"prostaglandins"
] | [
"hyperkalemia",
"oliguria",
"acute renal failure",
"cirrhosis",
"ascites",
"cor pulmonale",
"ascites",
"hyperkalemia",
"oliguria",
"cirrhosis",
"renal insufficiency",
"renal insufficiency"
] | [
{
"id": "1214",
"normalized": [
{
"db_id": "D006947",
"db_name": "MESH"
}
],
"offsets": [
[
130,
142
]
],
"text": [
"hyperkalemia"
],
"type": "Disease"
},
{
"id": "1220",
"normalized": [
{
"db_id"... | [
{
"id": "1211",
"normalized": [
{
"db_id": "D007213",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Indomethacin"
],
"type": "Chemical"
},
{
"id": "1211",
"normalized": [
{
"db_id": ... | [
true,
true,
false,
true,
true,
true,
false,
false,
false,
false,
true,
false
] |
Comparison of the subjective effects and plasma concentrations following oral and i.m. administration of flunitrazepam in volunteers. | Flunitrazepam 0.5, 1.0 or 2.0 mg was given by the oral or i.m. routes to groups of volunteers and its effects compared. Plasma concentrations of the drug were estimated by gas-liquid chromatography, in a smaller number of the subjects. The most striking effect was sedation which increased with the dose, 2 mg producing ... | [
{
"id": "1244",
"normalized": [
{
"db_id": "D005445",
"db_name": "MESH"
}
],
"offsets": [
[
105,
118
]
],
"text": [
"flunitrazepam"
],
"type": "Chemical"
},
{
"id": "1245",
"normalized": [
{
"db_i... | [
{
"id": "1246",
"normalized": [
{
"db_id": "D004244",
"db_name": "MESH"
}
],
"offsets": [
[
638,
647
]
],
"text": [
"Dizziness"
],
"type": "Disease"
},
{
"id": "1247",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes"
] | [
"flunitrazepam",
"flunitrazepam"
] | [
"Dizziness",
"pain"
] | [
{
"id": "1246",
"normalized": [
{
"db_id": "D004244",
"db_name": "MESH"
}
],
"offsets": [
[
638,
647
]
],
"text": [
"Dizziness"
],
"type": "Disease"
},
{
"id": "1247",
"normalized": [
{
"db_id": "... | [
{
"id": "1244",
"normalized": [
{
"db_id": "D005445",
"db_name": "MESH"
}
],
"offsets": [
[
105,
118
]
],
"text": [
"flunitrazepam"
],
"type": "Chemical"
},
{
"id": "1244",
"normalized": [
{
"db_i... | [
false,
false
] |
Changes in heart size during long-term timolol treatment after myocardial infarction. | The effect of long-term timolol treatment on heart size after myocardial infarction was evaluated by X-ray in a double-blind study including 241 patients (placebo 126, timolol 115). The follow-up period was 12 months. The timolol-treated patients showed a small but significant increase in heart size from baseline in co... | [
{
"id": "1258",
"normalized": [
{
"db_id": "D013999",
"db_name": "MESH"
}
],
"offsets": [
[
39,
46
]
],
"text": [
"timolol"
],
"type": "Chemical"
},
{
"id": "1260",
"normalized": [
{
"db_id": "D01... | [
{
"id": "1259",
"normalized": [
{
"db_id": "D009203",
"db_name": "MESH"
}
],
"offsets": [
[
63,
84
]
],
"text": [
"myocardial infarction"
],
"type": "Disease"
},
{
"id": "1261",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"timolol",
"timolol"
] | [
"cardiomegaly",
"myocardial infarction"
] | [
{
"id": "1267",
"normalized": [
{
"db_id": "D006332",
"db_name": "MESH"
}
],
"offsets": [
[
694,
706
]
],
"text": [
"cardiomegaly"
],
"type": "Disease"
},
{
"id": "1259",
"normalized": [
{
"db_id"... | [
{
"id": "1258",
"normalized": [
{
"db_id": "D013999",
"db_name": "MESH"
}
],
"offsets": [
[
39,
46
]
],
"text": [
"timolol"
],
"type": "Chemical"
},
{
"id": "1258",
"normalized": [
{
"db_id": "D01... | [
false,
true
] |
Vitamin D3 toxicity in dairy cows. | Large parenteral doses of vitamin D3 (15 to 17.5 x 10(6) IU vitamin D3) were associated with prolonged hypercalcemia, hyperphosphatemia, and large increases of vitamin D3 and its metabolites in the blood plasma of nonlactating nonpregnant and pregnant Jersey cows. Calcium concentrations 1 day postpartum were higher in ... | [
{
"id": "1280",
"normalized": [
{
"db_id": "D002762",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Vitamin D3"
],
"type": "Chemical"
},
{
"id": "1282",
"normalized": [
{
"db_id": "D... | [
{
"id": "1281",
"normalized": [
{
"db_id": "D064420",
"db_name": "MESH"
}
],
"offsets": [
[
11,
19
]
],
"text": [
"toxicity"
],
"type": "Disease"
},
{
"id": "1284",
"normalized": [
{
"db_id": "D00... | [
"Yes",
"Yes",
"No",
"No"
] | [
"Vitamin D3",
"Vitamin D3",
"Calcium",
"Calcium"
] | [
"hypercalcemia",
"hyperphosphatemia",
"toxicity",
"hypercalcemia"
] | [
{
"id": "1284",
"normalized": [
{
"db_id": "D006934",
"db_name": "MESH"
}
],
"offsets": [
[
138,
151
]
],
"text": [
"hypercalcemia"
],
"type": "Disease"
},
{
"id": "1285",
"normalized": [
{
"db_id... | [
{
"id": "1280",
"normalized": [
{
"db_id": "D002762",
"db_name": "MESH"
}
],
"offsets": [
[
0,
10
]
],
"text": [
"Vitamin D3"
],
"type": "Chemical"
},
{
"id": "1280",
"normalized": [
{
"db_id": "D... | [
true,
true,
false,
false
] |
Diseases of peripheral nerves as seen in the Nigerian African. | The anatomical and aetiological diagnoses of peripheral nerve disease excluding its primary benign and malignant disorders, as seen in 358 Nigerians are presented. There is a male preponderance and the peak incidence is in the fourth decade. Sensori-motor neuropathy was the commonest presentation (50%). Guillain-Barr ... | [
{
"id": "1335",
"normalized": [
{
"db_id": "D013831",
"db_name": "MESH"
}
],
"offsets": [
[
550,
558
]
],
"text": [
"thiamine"
],
"type": "Chemical"
},
{
"id": "1336",
"normalized": [
{
"db_id": "... | [
{
"id": "1328",
"normalized": [
{
"db_id": "D010523",
"db_name": "MESH"
}
],
"offsets": [
[
0,
29
]
],
"text": [
"Diseases of peripheral nerves"
],
"type": "Disease"
},
{
"id": "1329",
"normalized": [
{
... | [
"Yes",
"Yes",
"Yes",
"No",
"No",
"No"
] | [
"riboflavin",
"thiamine",
"Isoniazid",
"Isoniazid",
"thiamine",
"thiamine"
] | [
"Diseases of peripheral nerves",
"Diseases of peripheral nerves",
"Diseases of peripheral nerves",
"cranial neuropathy",
"Migraine",
"autonomic neuropathy"
] | [
{
"id": "1328",
"normalized": [
{
"db_id": "D010523",
"db_name": "MESH"
}
],
"offsets": [
[
0,
29
]
],
"text": [
"Diseases of peripheral nerves"
],
"type": "Disease"
},
{
"id": "1328",
"normalized": [
{
... | [
{
"id": "1336",
"normalized": [
{
"db_id": "D012256",
"db_name": "MESH"
}
],
"offsets": [
[
563,
573
]
],
"text": [
"riboflavin"
],
"type": "Chemical"
},
{
"id": "1335",
"normalized": [
{
"db_id":... | [
true,
true,
false,
false,
false,
false
] |
A double-blind study of the efficacy and safety of dothiepin hydrochloride in the treatment of major depressive disorder. | In a 6-week double-blind parallel treatment study, dothiepin and amitriptyline were compared to placebo in the treatment of 33 depressed outpatients. Dothiepin and amitriptyline were equally effective in alleviating the symptoms of depressive illness, and both were significantly superior to placebo. The overall inciden... | [
{
"id": "1369",
"normalized": [
{
"db_id": "D004308",
"db_name": "MESH"
}
],
"offsets": [
[
51,
74
]
],
"text": [
"dothiepin hydrochloride"
],
"type": "Chemical"
},
{
"id": "1371",
"normalized": [
{
... | [
{
"id": "1370",
"normalized": [
{
"db_id": "D003866",
"db_name": "MESH"
}
],
"offsets": [
[
101,
120
]
],
"text": [
"depressive disorder"
],
"type": "Disease"
},
{
"id": "1373",
"normalized": [
{
... | [
"Yes",
"Yes",
"No",
"No"
] | [
"amitriptyline",
"amitriptyline",
"antidepressant",
"antidepressant"
] | [
"blurred vision",
"dry mouth",
"dry mouth",
"blurred vision"
] | [
{
"id": "1377",
"normalized": [
{
"db_id": "D014786",
"db_name": "MESH"
}
],
"offsets": [
[
495,
509
]
],
"text": [
"blurred vision"
],
"type": "Disease"
},
{
"id": "1378",
"normalized": [
{
"db_i... | [
{
"id": "1372",
"normalized": [
{
"db_id": "D000639",
"db_name": "MESH"
}
],
"offsets": [
[
187,
200
]
],
"text": [
"amitriptyline"
],
"type": "Chemical"
},
{
"id": "1372",
"normalized": [
{
"db_i... | [
true,
true,
false,
false
] |
Behavioral effects of diazepam and propranolol in patients with panic disorder and agoraphobia. | The effects of oral doses of diazepam (single dose of 10 mg and a median dose of 30 mg/day for 2 weeks) and propranolol (single dose of 80 mg and a median dose of 240 mg/day for 2 weeks) on psychological performance of patients with panic disorders and agoraphobia were investigated in a double-blind, randomized and cro... | [
{
"id": "1397",
"normalized": [
{
"db_id": "D003975",
"db_name": "MESH"
}
],
"offsets": [
[
22,
30
]
],
"text": [
"diazepam"
],
"type": "Chemical"
},
{
"id": "1398",
"normalized": [
{
"db_id": "D0... | [
{
"id": "1399",
"normalized": [
{
"db_id": "D016584",
"db_name": "MESH"
}
],
"offsets": [
[
64,
78
]
],
"text": [
"panic disorder"
],
"type": "Disease"
},
{
"id": "1400",
"normalized": [
{
"db_id"... | [
"Yes",
"Yes",
"No",
"No"
] | [
"propranolol",
"diazepam",
"propranolol",
"diazepam"
] | [
"impaired immediate free recall",
"impaired immediate free recall",
"behavioral impairment",
"behavioral impairment"
] | [
{
"id": "1405",
"normalized": [
{
"db_id": "D008569",
"db_name": "MESH"
}
],
"offsets": [
[
442,
472
]
],
"text": [
"impaired immediate free recall"
],
"type": "Disease"
},
{
"id": "1405",
"normalized": [
... | [
{
"id": "1398",
"normalized": [
{
"db_id": "D011433",
"db_name": "MESH"
}
],
"offsets": [
[
35,
46
]
],
"text": [
"propranolol"
],
"type": "Chemical"
},
{
"id": "1397",
"normalized": [
{
"db_id": ... | [
true,
true,
false,
false
] |
Effect of aspirin on N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induced epithelial proliferation in the urinary bladder and forestomach of the rat. | The co-administration of aspirin with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) to rats resulted in a reduced incidence of FANFT-induced bladder carcinomas but a concomitant induction of forestomach tumors. An autoradiographic study was performed on male F-344 rats fed diet containing FANFT at a level of 0.... | [
{
"id": "1437",
"normalized": [
{
"db_id": "D001241",
"db_name": "MESH"
}
],
"offsets": [
[
10,
17
]
],
"text": [
"aspirin"
],
"type": "Chemical"
},
{
"id": "1438",
"normalized": [
{
"db_id": "D00... | [
{
"id": "1443",
"normalized": [
{
"db_id": "D001749",
"db_name": "MESH"
}
],
"offsets": [
[
300,
318
]
],
"text": [
"bladder carcinomas"
],
"type": "Disease"
},
{
"id": "1444",
"normalized": [
{
"... | [
"Yes",
"Yes",
"No",
"No"
] | [
"N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide",
"N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide",
"aspirin",
"aspirin"
] | [
"bladder carcinomas",
"forestomach tumors",
"carcinogenesis",
"bladder carcinomas"
] | [
{
"id": "1443",
"normalized": [
{
"db_id": "D001749",
"db_name": "MESH"
}
],
"offsets": [
[
300,
318
]
],
"text": [
"bladder carcinomas"
],
"type": "Disease"
},
{
"id": "1444",
"normalized": [
{
"... | [
{
"id": "1438",
"normalized": [
{
"db_id": "D005200",
"db_name": "MESH"
}
],
"offsets": [
[
21,
66
]
],
"text": [
"N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide"
],
"type": "Chemical"
},
{
"id": "1438",
"normal... | [
true,
true,
true,
true
] |
Provocation of postural hypotension by nitroglycerin in diabetic autonomic neuropathy? | The effect of nitroglycerin on heart rate and systolic blood pressure was compared in 5 normal subjects, 12 diabetic subjects without autonomic neuropathy, and 5 diabetic subjects with autonomic neuropathy. The magnitude and time course of the increase in heart rate and the decrease in systolic blood pressure after nit... | [
{
"id": "1482",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
39,
52
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "1484",
"normalized": [
{
"db_id"... | [
{
"id": "1481",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
24,
35
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "1483",
"normalized": [
{
"db_id": "... | [
"Yes",
"No"
] | [
"nitroglycerin",
"nitroglycerin"
] | [
"hypotension",
"diabetic"
] | [
{
"id": "1481",
"normalized": [
{
"db_id": "D007022",
"db_name": "MESH"
}
],
"offsets": [
[
24,
35
]
],
"text": [
"hypotension"
],
"type": "Disease"
},
{
"id": "1485",
"normalized": [
{
"db_id": "... | [
{
"id": "1482",
"normalized": [
{
"db_id": "D005996",
"db_name": "MESH"
}
],
"offsets": [
[
39,
52
]
],
"text": [
"nitroglycerin"
],
"type": "Chemical"
},
{
"id": "1482",
"normalized": [
{
"db_id"... | [
true,
true
] |
Characterization of estrogen-induced adenohypophyseal tumors in the Fischer 344 rat. | Pituitary tumors were induced in F344 female rats by chronic treatment with diethylstilbestrol (DES, 8-10 mg) implanted subcutaneously in silastic capsules. Over a range of 1-150 days of DES treatment, pairs of control and DES-treated rats were sacrificed, and their pituitaries dissociated enzymatically into single-cel... | [
{
"id": "1502",
"normalized": [
{
"db_id": "D004967",
"db_name": "MESH"
}
],
"offsets": [
[
20,
28
]
],
"text": [
"estrogen"
],
"type": "Chemical"
},
{
"id": "1505",
"normalized": [
{
"db_id": "D0... | [
{
"id": "1503",
"normalized": [
{
"db_id": "D010911",
"db_name": "MESH"
}
],
"offsets": [
[
37,
60
]
],
"text": [
"adenohypophyseal tumors"
],
"type": "Disease"
},
{
"id": "1504",
"normalized": [
{
... | [
"Yes",
"No"
] | [
"diethylstilbestrol",
"estrogen"
] | [
"adenohypophyseal tumors",
"adenohypophyseal tumors"
] | [
{
"id": "1503",
"normalized": [
{
"db_id": "D010911",
"db_name": "MESH"
}
],
"offsets": [
[
37,
60
]
],
"text": [
"adenohypophyseal tumors"
],
"type": "Disease"
},
{
"id": "1503",
"normalized": [
{
... | [
{
"id": "1505",
"normalized": [
{
"db_id": "D004054",
"db_name": "MESH"
}
],
"offsets": [
[
161,
179
]
],
"text": [
"diethylstilbestrol"
],
"type": "Chemical"
},
{
"id": "1502",
"normalized": [
{
... | [
true,
true
] |
Triamterene nephrolithiasis complicating dyazide therapy. | A case of triamterene nephrolithiasis is reported in a man after 4 years of hydrochlorothiazide-triamterene therapy for hypertension. The stone passed spontaneously and was found to contain a triamterene metabolite admixed with uric acid salts. Factors affecting triamterene nephrolithiasis are discussed and 2 previousl... | [
{
"id": "1537",
"normalized": [
{
"db_id": "D014223",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Triamterene"
],
"type": "Chemical"
},
{
"id": "1539",
"normalized": [
{
"db_id": "... | [
{
"id": "1538",
"normalized": [
{
"db_id": "D053040",
"db_name": "MESH"
}
],
"offsets": [
[
12,
27
]
],
"text": [
"nephrolithiasis"
],
"type": "Disease"
},
{
"id": "1541",
"normalized": [
{
"db_id... | [
"Yes",
"No"
] | [
"Triamterene",
"uric acid salts"
] | [
"nephrolithiasis",
"nephrolithiasis"
] | [
{
"id": "1538",
"normalized": [
{
"db_id": "D053040",
"db_name": "MESH"
}
],
"offsets": [
[
12,
27
]
],
"text": [
"nephrolithiasis"
],
"type": "Disease"
},
{
"id": "1538",
"normalized": [
{
"db_id... | [
{
"id": "1537",
"normalized": [
{
"db_id": "D014223",
"db_name": "MESH"
}
],
"offsets": [
[
0,
11
]
],
"text": [
"Triamterene"
],
"type": "Chemical"
},
{
"id": "1545",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Metabolic involvement in adriamycin cardiotoxicity. | The cardiotoxic effects of adriamycin were studied in mammalian myocardial cells in culture as a model system. Adriamycin inhibited cell growth and the rhythmic contractions characteristic of myocardial cells in culture. A possible involvement of energy metabolism was suggested previously, and in this study the adenyla... | [
{
"id": "1563",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
25,
35
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "1566",
"normalized": [
{
"db_id": "... | [
{
"id": "1564",
"normalized": [
{
"db_id": "D066126",
"db_name": "MESH"
}
],
"offsets": [
[
36,
50
]
],
"text": [
"cardiotoxicity"
],
"type": "Disease"
},
{
"id": "1565",
"normalized": [
{
"db_id"... | [
"Yes",
"No"
] | [
"adriamycin",
"phosphorylcreatine"
] | [
"cardiotoxicity",
"cardiotoxicity"
] | [
{
"id": "1564",
"normalized": [
{
"db_id": "D066126",
"db_name": "MESH"
}
],
"offsets": [
[
36,
50
]
],
"text": [
"cardiotoxicity"
],
"type": "Disease"
},
{
"id": "1564",
"normalized": [
{
"db_id"... | [
{
"id": "1563",
"normalized": [
{
"db_id": "D004317",
"db_name": "MESH"
}
],
"offsets": [
[
25,
35
]
],
"text": [
"adriamycin"
],
"type": "Chemical"
},
{
"id": "1568",
"normalized": [
{
"db_id": "... | [
true,
false
] |
Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin. | Streptomycin sulfate (300 mg/kg s.c.) was injected for various periods into preweanling rats and for 3 weeks into weanling rats. Beginning at 8 days of age, body movement and hearing were examined for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweaning... | [
{
"id": "1591",
"normalized": [
{
"db_id": "D013307",
"db_name": "MESH"
}
],
"offsets": [
[
62,
74
]
],
"text": [
"streptomycin"
],
"type": "Chemical"
},
{
"id": "1592",
"normalized": [
{
"db_id":... | [
{
"id": "1590",
"normalized": [
{
"db_id": "D020258",
"db_name": "MESH"
}
],
"offsets": [
[
40,
50
]
],
"text": [
"neurotoxic"
],
"type": "Disease"
},
{
"id": "1593",
"normalized": [
{
"db_id": "D... | [
"Yes",
"Yes",
"No"
] | [
"streptomycin",
"streptomycin",
"streptomycin"
] | [
"Abnormal movements",
"deafness",
"neurotoxic"
] | [
{
"id": "1593",
"normalized": [
{
"db_id": "D004409",
"db_name": "MESH"
}
],
"offsets": [
[
313,
331
]
],
"text": [
"Abnormal movements"
],
"type": "Disease"
},
{
"id": "1594",
"normalized": [
{
"... | [
{
"id": "1591",
"normalized": [
{
"db_id": "D013307",
"db_name": "MESH"
}
],
"offsets": [
[
62,
74
]
],
"text": [
"streptomycin"
],
"type": "Chemical"
},
{
"id": "1591",
"normalized": [
{
"db_id":... | [
true,
true,
true
] |
Crescentic fibrillary glomerulonephritis associated with intermittent rifampin therapy for pulmonary tuberculosis. | This case study reveals an unusual finding of rapidly proliferative crescentic glomerulonephritis in a patient treated with rifampin who had no other identifiable causes for developing this disease. This patient underwent a 10-month regimen of rifampin and isoniazid for pulmonary tuberculosis and was discovered to have... | [
{
"id": "1610",
"normalized": [
{
"db_id": "D012293",
"db_name": "MESH"
}
],
"offsets": [
[
70,
78
]
],
"text": [
"rifampin"
],
"type": "Chemical"
},
{
"id": "1613",
"normalized": [
{
"db_id": "D0... | [
{
"id": "1609",
"normalized": [
{
"db_id": "D005921",
"db_name": "MESH"
}
],
"offsets": [
[
22,
40
]
],
"text": [
"glomerulonephritis"
],
"type": "Disease"
},
{
"id": "1611",
"normalized": [
{
"db... | [
"Yes",
"Yes",
"No",
"No"
] | [
"rifampin",
"rifampin",
"isoniazid",
"isoniazid"
] | [
"glomerulonephritis",
"renal failure",
"glomerulonephritis",
"pulmonary tuberculosis"
] | [
{
"id": "1609",
"normalized": [
{
"db_id": "D005921",
"db_name": "MESH"
}
],
"offsets": [
[
22,
40
]
],
"text": [
"glomerulonephritis"
],
"type": "Disease"
},
{
"id": "1617",
"normalized": [
{
"db... | [
{
"id": "1610",
"normalized": [
{
"db_id": "D012293",
"db_name": "MESH"
}
],
"offsets": [
[
70,
78
]
],
"text": [
"rifampin"
],
"type": "Chemical"
},
{
"id": "1610",
"normalized": [
{
"db_id": "D0... | [
true,
true,
false,
true
] |
Time course of lipid peroxidation in puromycin aminonucleoside-induced nephropathy. | Reactive oxygen species have been implicated in the pathogenesis of acute puromycin aminonucleoside (PAN)-induced nephropathy, with antioxidants significantly reducing the proteinuria. The temporal relationship between lipid peroxidation in the kidney and proteinuria was examined in this study. Rats were treated with a... | [
{
"id": "1654",
"normalized": [
{
"db_id": "D011692",
"db_name": "MESH"
}
],
"offsets": [
[
37,
62
]
],
"text": [
"puromycin aminonucleoside"
],
"type": "Chemical"
},
{
"id": "1656",
"normalized": [
{
... | [
{
"id": "1655",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
71,
82
]
],
"text": [
"nephropathy"
],
"type": "Disease"
},
{
"id": "1659",
"normalized": [
{
"db_id": "... | [
"Yes",
"Yes",
"No",
"No"
] | [
"puromycin aminonucleoside",
"puromycin aminonucleoside",
"oxygen",
"thiobarbituric acid"
] | [
"nephropathy",
"proteinuria",
"nephropathy",
"proteinuria"
] | [
{
"id": "1655",
"normalized": [
{
"db_id": "D007674",
"db_name": "MESH"
}
],
"offsets": [
[
71,
82
]
],
"text": [
"nephropathy"
],
"type": "Disease"
},
{
"id": "1660",
"normalized": [
{
"db_id": "... | [
{
"id": "1654",
"normalized": [
{
"db_id": "D011692",
"db_name": "MESH"
}
],
"offsets": [
[
37,
62
]
],
"text": [
"puromycin aminonucleoside"
],
"type": "Chemical"
},
{
"id": "1654",
"normalized": [
{
... | [
true,
true,
true,
false
] |
Clomipramine-induced sleep disturbance does not impair its prolactin-releasing action. | The present study was undertaken to examine the role of sleep disturbance, induced by clomipramine administration, on the secretory rate of prolactin (PRL) in addition to the direct drug effect. Two groups of supine subjects were studied under placebo-controlled conditions, one during the night, when sleeping (n = 7) a... | [
{
"id": "1714",
"normalized": [
{
"db_id": "D002997",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Clomipramine"
],
"type": "Chemical"
},
{
"id": "1717",
"normalized": [
{
"db_id": ... | [
{
"id": "1715",
"normalized": [
{
"db_id": "D012893",
"db_name": "MESH"
}
],
"offsets": [
[
21,
38
]
],
"text": [
"sleep disturbance"
],
"type": "Disease"
},
{
"id": "1716",
"normalized": [
{
"db_... | [
"Yes"
] | [
"Clomipramine"
] | [
"sleep disturbance"
] | [
{
"id": "1715",
"normalized": [
{
"db_id": "D012893",
"db_name": "MESH"
}
],
"offsets": [
[
21,
38
]
],
"text": [
"sleep disturbance"
],
"type": "Disease"
}
] | [
{
"id": "1714",
"normalized": [
{
"db_id": "D002997",
"db_name": "MESH"
}
],
"offsets": [
[
0,
12
]
],
"text": [
"Clomipramine"
],
"type": "Chemical"
}
] | [
true
] |
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