| <!DOCTYPE html>
|
| <html lang="en">
|
| <head>
|
| <meta charset="UTF-8">
|
| <title>Z-Screen Data Shape Explorer</title>
|
| <link href="https://fonts.googleapis.com/css2?family=Outfit:wght@300;400;500;600;700&family=JetBrains+Mono:wght@400;500&display=swap" rel="stylesheet">
|
| <script src="https://cdn.jsdelivr.net/npm/chart.js"></script>
|
| <style>
|
| :root {
|
| --bg-color: #0b0f19;
|
| --card-bg: rgba(17, 25, 40, 0.75);
|
| --border-color: rgba(255, 255, 255, 0.08);
|
| --text-color: #f3f4f6;
|
| --text-muted: #9ca3af;
|
| --primary: #8b5cf6;
|
| --primary-glow: rgba(139, 92, 246, 0.4);
|
| --secondary: #06b6d4;
|
| --accent: #f43f5e;
|
| --font-main: 'Outfit', sans-serif;
|
| --font-mono: 'JetBrains Mono', monospace;
|
| }
|
|
|
| * {
|
| box-sizing: border-box;
|
| margin: 0;
|
| padding: 0;
|
| }
|
|
|
| body {
|
| background-color: var(--bg-color);
|
| color: var(--text-color);
|
| font-family: var(--font-main);
|
| min-height: 100vh;
|
| overflow-x: hidden;
|
| background-image:
|
| radial-gradient(at 0% 0%, rgba(99, 102, 241, 0.1) 0, transparent 50%),
|
| radial-gradient(at 50% 0%, rgba(139, 92, 246, 0.08) 0, transparent 50%),
|
| radial-gradient(at 100% 100%, rgba(6, 182, 212, 0.08) 0, transparent 50%);
|
| background-attachment: fixed;
|
| }
|
|
|
| header {
|
| padding: 2.5rem 4rem 1.5rem 4rem;
|
| border-bottom: 1px solid var(--border-color);
|
| background: rgba(11, 15, 25, 0.8);
|
| backdrop-filter: blur(12px);
|
| position: sticky;
|
| top: 0;
|
| z-index: 100;
|
| display: flex;
|
| justify-content: space-between;
|
| align-items: center;
|
| }
|
|
|
| .header-title h1 {
|
| font-size: 1.8rem;
|
| font-weight: 700;
|
| background: linear-gradient(135deg, #fff 30%, var(--primary) 70%, var(--secondary) 100%);
|
| -webkit-background-clip: text;
|
| -webkit-text-fill-color: transparent;
|
| margin-bottom: 0.25rem;
|
| }
|
|
|
| .header-title p {
|
| color: var(--text-muted);
|
| font-size: 0.95rem;
|
| }
|
|
|
| .nav-tabs {
|
| display: flex;
|
| gap: 0.5rem;
|
| background: rgba(255, 255, 255, 0.03);
|
| padding: 0.35rem;
|
| border-radius: 30px;
|
| border: 1px solid var(--border-color);
|
| }
|
|
|
| .tab-btn {
|
| background: transparent;
|
| border: none;
|
| color: var(--text-muted);
|
| padding: 0.6rem 1.4rem;
|
| font-size: 0.9rem;
|
| font-weight: 500;
|
| border-radius: 25px;
|
| cursor: pointer;
|
| transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
|
| }
|
|
|
| .tab-btn.active {
|
| background: var(--primary);
|
| color: #fff;
|
| box-shadow: 0 0 15px var(--primary-glow);
|
| }
|
|
|
| .tab-btn:hover:not(.active) {
|
| color: #fff;
|
| background: rgba(255, 255, 255, 0.05);
|
| }
|
|
|
| .container {
|
| max-width: 1400px;
|
| margin: 2rem auto;
|
| padding: 0 2rem;
|
| }
|
|
|
| .tab-content {
|
| display: none;
|
| }
|
|
|
| .tab-content.active {
|
| display: block;
|
| animation: fadeIn 0.4s ease-out;
|
| }
|
|
|
| @keyframes fadeIn {
|
| from { opacity: 0; transform: translateY(10px); }
|
| to { opacity: 1; transform: translateY(0); }
|
| }
|
|
|
|
|
| .stats-grid {
|
| display: grid;
|
| grid-template-columns: repeat(auto-fit, minmax(220px, 1fr));
|
| gap: 1.5rem;
|
| margin-bottom: 2rem;
|
| }
|
|
|
| .stat-card {
|
| background: var(--card-bg);
|
| border: 1px solid var(--border-color);
|
| border-radius: 16px;
|
| padding: 1.5rem;
|
| backdrop-filter: blur(16px);
|
| position: relative;
|
| overflow: hidden;
|
| transition: border-color 0.3s;
|
| }
|
|
|
| .stat-card:hover {
|
| border-color: rgba(139, 92, 246, 0.3);
|
| }
|
|
|
| .stat-card::before {
|
| content: '';
|
| position: absolute;
|
| top: 0;
|
| left: 0;
|
| width: 4px;
|
| height: 100%;
|
| background: var(--primary);
|
| }
|
|
|
| .stat-card.cyan::before { background: var(--secondary); }
|
| .stat-card.accent::before { background: var(--accent); }
|
|
|
| .stat-label {
|
| color: var(--text-muted);
|
| font-size: 0.85rem;
|
| text-transform: uppercase;
|
| letter-spacing: 0.05em;
|
| margin-bottom: 0.5rem;
|
| }
|
|
|
| .stat-value {
|
| font-size: 2.2rem;
|
| font-weight: 700;
|
| margin-bottom: 0.25rem;
|
| font-family: var(--font-mono);
|
| }
|
|
|
| .stat-subtext {
|
| color: var(--text-muted);
|
| font-size: 0.85rem;
|
| }
|
|
|
| .grid-2col {
|
| display: grid;
|
| grid-template-columns: 1fr 1fr;
|
| gap: 2rem;
|
| margin-bottom: 2rem;
|
| }
|
|
|
| @media (max-width: 900px) {
|
| .grid-2col {
|
| grid-template-columns: 1fr;
|
| }
|
| }
|
|
|
| .panel {
|
| background: var(--card-bg);
|
| border: 1px solid var(--border-color);
|
| border-radius: 20px;
|
| padding: 2rem;
|
| backdrop-filter: blur(16px);
|
| }
|
|
|
| .panel-title {
|
| font-size: 1.25rem;
|
| font-weight: 600;
|
| margin-bottom: 1.5rem;
|
| display: flex;
|
| align-items: center;
|
| justify-content: space-between;
|
| }
|
|
|
| .panel-subtitle {
|
| color: var(--text-muted);
|
| font-size: 0.9rem;
|
| font-weight: 400;
|
| }
|
|
|
|
|
| .heatmap-container {
|
| display: flex;
|
| flex-direction: column;
|
| overflow-x: auto;
|
| }
|
|
|
| .heatmap-grid {
|
| display: grid;
|
| grid-template-columns: 120px repeat(6, 1fr);
|
| gap: 6px;
|
| margin-top: 1rem;
|
| min-width: 700px;
|
| }
|
|
|
| .heatmap-header-cell {
|
| font-size: 0.9rem;
|
| font-weight: 600;
|
| text-align: center;
|
| padding: 0.75rem 0.5rem;
|
| color: var(--text-muted);
|
| }
|
|
|
| .heatmap-label-cell {
|
| font-size: 0.85rem;
|
| font-weight: 500;
|
| display: flex;
|
| align-items: center;
|
| justify-content: flex-end;
|
| padding-right: 1rem;
|
| font-family: var(--font-mono);
|
| }
|
|
|
| .heatmap-cell {
|
| border-radius: 6px;
|
| padding: 1.2rem 0.5rem;
|
| text-align: center;
|
| font-size: 0.85rem;
|
| font-weight: 600;
|
| cursor: pointer;
|
| transition: transform 0.2s, box-shadow 0.2s;
|
| display: flex;
|
| flex-direction: column;
|
| justify-content: center;
|
| align-items: center;
|
| }
|
|
|
| .heatmap-cell:hover {
|
| transform: scale(1.05);
|
| z-index: 10;
|
| box-shadow: 0 0 12px rgba(255, 255, 255, 0.15);
|
| }
|
|
|
| .heatmap-cell-value {
|
| font-family: var(--font-mono);
|
| font-size: 0.85rem;
|
| }
|
|
|
| .heatmap-cell-pct {
|
| font-size: 0.7rem;
|
| font-weight: 400;
|
| opacity: 0.8;
|
| margin-top: 2px;
|
| }
|
|
|
| .heatmap-legend {
|
| display: flex;
|
| gap: 1.5rem;
|
| margin-top: 2rem;
|
| justify-content: center;
|
| font-size: 0.85rem;
|
| color: var(--text-muted);
|
| }
|
|
|
| .legend-item {
|
| display: flex;
|
| align-items: center;
|
| gap: 0.5rem;
|
| }
|
|
|
| .legend-color {
|
| width: 16px;
|
| height: 16px;
|
| border-radius: 4px;
|
| }
|
|
|
|
|
| .search-box {
|
| display: flex;
|
| gap: 1rem;
|
| margin-bottom: 1.5rem;
|
| }
|
|
|
| .search-input {
|
| flex: 1;
|
| background: rgba(255, 255, 255, 0.05);
|
| border: 1px solid var(--border-color);
|
| border-radius: 30px;
|
| padding: 0.75rem 1.5rem;
|
| color: #fff;
|
| font-family: var(--font-main);
|
| font-size: 0.95rem;
|
| outline: none;
|
| transition: border-color 0.3s;
|
| }
|
|
|
| .search-input:focus {
|
| border-color: var(--primary);
|
| }
|
|
|
| .filter-select {
|
| background: rgba(255, 255, 255, 0.05);
|
| border: 1px solid var(--border-color);
|
| border-radius: 30px;
|
| padding: 0.75rem 1.5rem;
|
| color: #fff;
|
| font-family: var(--font-main);
|
| outline: none;
|
| cursor: pointer;
|
| }
|
|
|
| .table-wrapper {
|
| overflow-x: auto;
|
| border-radius: 12px;
|
| border: 1px solid var(--border-color);
|
| }
|
|
|
| table {
|
| width: 100%;
|
| border-collapse: collapse;
|
| text-align: left;
|
| font-size: 0.9rem;
|
| }
|
|
|
| th {
|
| background: rgba(255, 255, 255, 0.02);
|
| font-weight: 600;
|
| color: var(--text-muted);
|
| padding: 1rem;
|
| border-bottom: 1px solid var(--border-color);
|
| text-transform: uppercase;
|
| font-size: 0.8rem;
|
| letter-spacing: 0.05em;
|
| }
|
|
|
| td {
|
| padding: 1rem;
|
| border-bottom: 1px solid var(--border-color);
|
| vertical-align: middle;
|
| }
|
|
|
| tr:last-child td {
|
| border-bottom: none;
|
| }
|
|
|
| tr:hover td {
|
| background: rgba(255, 255, 255, 0.01);
|
| }
|
|
|
| .badge {
|
| display: inline-block;
|
| padding: 0.3rem 0.6rem;
|
| border-radius: 20px;
|
| font-size: 0.75rem;
|
| font-weight: 600;
|
| text-transform: uppercase;
|
| }
|
|
|
| .badge-purple { background: rgba(139, 92, 246, 0.15); color: #a78bfa; border: 1px solid rgba(139, 92, 246, 0.3); }
|
| .badge-cyan { background: rgba(6, 182, 212, 0.15); color: #22d3ee; border: 1px solid rgba(6, 182, 212, 0.3); }
|
| .badge-rose { background: rgba(244, 63, 94, 0.15); color: #fb7185; border: 1px solid rgba(244, 63, 94, 0.3); }
|
| .badge-orange { background: rgba(249, 115, 22, 0.15); color: #fdba74; border: 1px solid rgba(249, 115, 22, 0.3); }
|
| .badge-blue { background: rgba(59, 130, 246, 0.15); color: #60a5fa; border: 1px solid rgba(59, 130, 246, 0.3); }
|
|
|
|
|
| .lib-grid {
|
| display: grid;
|
| grid-template-columns: repeat(auto-fill, minmax(320px, 1fr));
|
| gap: 1.5rem;
|
| }
|
|
|
| .lib-card {
|
| background: var(--card-bg);
|
| border: 1px solid var(--border-color);
|
| border-radius: 16px;
|
| padding: 1.5rem;
|
| backdrop-filter: blur(12px);
|
| display: flex;
|
| flex-direction: column;
|
| justify-content: space-between;
|
| }
|
|
|
| .lib-name {
|
| font-size: 1.2rem;
|
| font-weight: 600;
|
| margin-bottom: 0.5rem;
|
| font-family: var(--font-mono);
|
| display: flex;
|
| justify-content: space-between;
|
| align-items: center;
|
| }
|
|
|
| .lib-details-row {
|
| display: flex;
|
| justify-content: space-between;
|
| padding: 0.4rem 0;
|
| border-bottom: 1px solid rgba(255, 255, 255, 0.04);
|
| font-size: 0.9rem;
|
| }
|
|
|
| .lib-details-row:last-child {
|
| border-bottom: none;
|
| }
|
|
|
| .lib-details-label {
|
| color: var(--text-muted);
|
| }
|
|
|
| .lib-details-val {
|
| font-family: var(--font-mono);
|
| font-weight: 500;
|
| }
|
|
|
| .roles-list {
|
| margin-top: 1rem;
|
| display: flex;
|
| flex-wrap: wrap;
|
| gap: 0.5rem;
|
| }
|
| </style>
|
| </head>
|
| <body>
|
|
|
| <header>
|
| <div class="header-title">
|
| <h1>Z-Screen Data Shape Explorer</h1>
|
| <p>Interactive structural visualization of nanowells, devices, cell lines, and libraries</p>
|
| </div>
|
| <div class="nav-tabs">
|
| <button class="tab-btn active" onclick="switchTab('tab-overview')">Overview</button>
|
| <button class="tab-btn" onclick="switchTab('tab-matrix')">Screen Matrix</button>
|
| <button class="tab-btn" onclick="switchTab('tab-devices')">Device Mapping</button>
|
| <button class="tab-btn" onclick="switchTab('tab-libraries')">Libraries</button>
|
| </div>
|
| </header>
|
|
|
| <div class="container">
|
|
|
|
|
| <div id="tab-overview" class="tab-content active">
|
| <div class="stats-grid">
|
| <div class="stat-card">
|
| <div class="stat-label">Total Observations (Nanowells)</div>
|
| <div class="stat-value">768,162</div>
|
| <div class="stat-subtext">Mapped across 49 devices</div>
|
| </div>
|
| <div class="stat-card cyan">
|
| <div class="stat-label">Total Features (Genes)</div>
|
| <div class="stat-value">46,944</div>
|
| <div class="stat-subtext">In counts.h5ad matrix</div>
|
| </div>
|
| <div class="stat-card">
|
| <div class="stat-label">Screening Devices</div>
|
| <div class="stat-value">49</div>
|
| <div class="stat-subtext">Numbered 0 to 48</div>
|
| </div>
|
| <div class="stat-card accent">
|
| <div class="stat-label">Unique Compounds</div>
|
| <div class="stat-value">142,227</div>
|
| <div class="stat-subtext">Including 142.1k building blocks</div>
|
| </div>
|
| </div>
|
|
|
|
|
| <div class="panel" style="margin-bottom: 2rem; border-left: 4px solid var(--secondary); background: rgba(6, 182, 212, 0.04);">
|
| <h3 style="color: var(--secondary); font-size: 1.1rem; margin-bottom: 0.5rem; display: flex; align-items: center; gap: 0.5rem;">
|
| 🔬 Nanowell Architecture Specification
|
| </h3>
|
| <p style="color: var(--text-color); font-size: 0.95rem; line-height: 1.5;">
|
| Each observation (row) in the dataset corresponds to a single **nanowell** rather than a single cell. Each nanowell measures **90 microns in diameter by 120 microns tall** and holds approximately **2 to 10 cells**. The transcriptomic profiles represent the pooled expression of the cells inside each nanowell.
|
| </p>
|
| </div>
|
|
|
| <div class="grid-2col">
|
| <div class="panel">
|
| <div class="panel-title">
|
| <span>Nanowells per Cell Line</span>
|
| <span class="panel-subtitle">Total profiled nanowells</span>
|
| </div>
|
| <div style="height: 300px; position: relative;">
|
| <canvas id="cellLineChart"></canvas>
|
| </div>
|
| </div>
|
| <div class="panel">
|
| <div class="panel-title">
|
| <span>Dataset Role Split</span>
|
| <span class="panel-subtitle">By screening category (wells)</span>
|
| </div>
|
| <div style="height: 300px; position: relative;">
|
| <canvas id="roleChart"></canvas>
|
| </div>
|
| </div>
|
| </div>
|
|
|
| <div class="panel" style="margin-top: 2rem;">
|
| <div class="panel-title">Key Structural Insights</div>
|
| <div style="line-height: 1.6; display: grid; grid-template-columns: 1fr 1fr; gap: 2.5rem;">
|
| <div>
|
| <h3 style="margin-bottom: 0.5rem; color: var(--secondary);">🔬 Multiplexed Chip Architecture</h3>
|
| <p style="color: var(--text-muted); margin-bottom: 1.25rem;">
|
| Each physical device runs exactly <strong>one cell line</strong>. This eliminates cell mixing within a single microfluidic chip, enabling clean downstream sorting. However, multiple chemical libraries are pooled on each chip (ranging from 2 to 8 libraries per device).
|
| </p>
|
| </div>
|
| <div>
|
| <h3 style="margin-bottom: 0.5rem; color: var(--accent);">🧪 Named Control Compounds vs. Combinatorial Libraries</h3>
|
| <p style="color: var(--text-muted); margin-bottom: 1.25rem;">
|
| The screen features a split between **One-Bead One-Compound (OBOC) combinatorial libraries** (testing 142.1k chemical precursor fragments across 353.3k wells) and **Named Control Compounds** (testing 78 fully synthesized target compounds across 311.3k wells).
|
| </p>
|
| <h3 style="margin-bottom: 0.5rem; color: var(--primary);">🛡️ No-Compound Control Beads</h3>
|
| <p style="color: var(--text-muted);">
|
| Out of 49 devices, <strong>24 devices</strong> contain no-compound controls (including capture-only control bead library `ZEL026-2` and water/vehicle controls like `ZIC005`). Only <strong>Device 11</strong> lacks control beads entirely, profiling named control compounds exclusively.
|
| </p>
|
| </div>
|
| </div>
|
| </div>
|
| </div>
|
|
|
|
|
| <div id="tab-matrix" class="tab-content">
|
| <div class="panel">
|
| <div class="panel-title">
|
| <div>
|
| Screening Matrix Map
|
| <div class="panel-subtitle">Nanowell counts mapped per library (rows) and cell line (columns)</div>
|
| </div>
|
| </div>
|
| <div class="heatmap-container">
|
| <div class="heatmap-grid" id="heatmapGrid">
|
|
|
| </div>
|
| <div class="heatmap-legend">
|
| <div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.05); border: 1px solid var(--border-color);"></div> Not Screened</div>
|
| <div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.25);"></div> low (< 2,000 wells)</div>
|
| <div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.55);"></div> medium (2k - 25k wells)</div>
|
| <div class="legend-item"><div class="legend-color" style="background: rgba(139, 92, 246, 0.85);"></div> high (> 25k wells)</div>
|
| </div>
|
| </div>
|
| </div>
|
| </div>
|
|
|
|
|
| <div id="tab-devices" class="tab-content">
|
| <div class="panel">
|
| <div class="panel-title">
|
| <div>
|
| Device-Level Screen Map
|
| <div class="panel-subtitle">Search, filter, and inspect cell line labels and pooled libraries per device</div>
|
| </div>
|
| </div>
|
|
|
| <div class="search-box">
|
| <input type="text" id="deviceSearch" class="search-input" placeholder="Search devices by ID, cell line, or library..." oninput="filterDevices()">
|
| <select id="cellLineFilter" class="filter-select" onchange="filterDevices()">
|
| <option value="">All Cell Lines</option>
|
| <option value="HEK293">HEK293</option>
|
| <option value="HEK293-clone">HEK293-clone</option>
|
| <option value="A549">A549</option>
|
| <option value="H1650">H1650</option>
|
| <option value="THP1">THP1</option>
|
| <option value="AEC7">AEC7</option>
|
| </select>
|
| </div>
|
|
|
| <div class="table-wrapper">
|
| <table id="deviceTable">
|
| <thead>
|
| <tr>
|
| <th>Device ID</th>
|
| <th>Cell Line</th>
|
| <th>Libraries Screened</th>
|
| <th>Nanowell Count</th>
|
| <th>Treatment Split</th>
|
| </tr>
|
| </thead>
|
| <tbody id="deviceTableBody">
|
|
|
| </tbody>
|
| </table>
|
| </div>
|
| </div>
|
| </div>
|
|
|
|
|
| <div id="tab-libraries" class="tab-content">
|
| <div class="panel">
|
| <div class="panel-title">
|
| <div>
|
| Screened Chemical Libraries & Control Sets
|
| <div class="panel-subtitle">Details of compound counts, SMILES configurations, and nomenclature types</div>
|
| </div>
|
| </div>
|
| <div class="lib-grid" id="libGrid">
|
|
|
| </div>
|
| </div>
|
| </div>
|
|
|
| </div>
|
|
|
| <script>
|
|
|
| const results = {
|
| "compounds_per_library": {
|
| "ZIC008": {
|
| "unique_public_compound_ids": 35,
|
| "unique_smiles": 35,
|
| "unique_names": 35,
|
| "condition_roles": {
|
| "compound_treatment": 256052
|
| }
|
| },
|
| "ZEL026-2": {
|
| "unique_public_compound_ids": 0,
|
| "unique_smiles": 0,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "capture_only": 95583
|
| }
|
| },
|
| "ZEL031": {
|
| "unique_public_compound_ids": 10265,
|
| "unique_smiles": 10265,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "building_block_treatment": 43241
|
| }
|
| },
|
| "ZEL028-2": {
|
| "unique_public_compound_ids": 117950,
|
| "unique_smiles": 117950,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "building_block_treatment": 134821
|
| }
|
| },
|
| "ZIC004": {
|
| "unique_public_compound_ids": 1,
|
| "unique_smiles": 1,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "compound_treatment": 1913
|
| }
|
| },
|
| "ZIC006": {
|
| "unique_public_compound_ids": 1,
|
| "unique_smiles": 1,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "compound_treatment": 2099
|
| }
|
| },
|
| "ZIC003": {
|
| "unique_public_compound_ids": 2,
|
| "unique_smiles": 2,
|
| "unique_names": 2,
|
| "condition_roles": {
|
| "compound_treatment": 1880
|
| }
|
| },
|
| "ZIC002": {
|
| "unique_public_compound_ids": 7,
|
| "unique_smiles": 7,
|
| "unique_names": 7,
|
| "condition_roles": {
|
| "compound_treatment": 10999
|
| }
|
| },
|
| "ZIC001": {
|
| "unique_public_compound_ids": 2,
|
| "unique_smiles": 2,
|
| "unique_names": 2,
|
| "condition_roles": {
|
| "compound_treatment": 6569
|
| }
|
| },
|
| "ZEL024": {
|
| "unique_public_compound_ids": 13934,
|
| "unique_smiles": 13934,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "building_block_treatment": 175285
|
| }
|
| },
|
| "ZIC005": {
|
| "unique_public_compound_ids": 1,
|
| "unique_smiles": 0,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "compound_treatment": 157
|
| }
|
| },
|
| "ZIC007": {
|
| "unique_public_compound_ids": 4,
|
| "unique_smiles": 4,
|
| "unique_names": 4,
|
| "condition_roles": {
|
| "compound_treatment": 565
|
| }
|
| },
|
| "ZIC009": {
|
| "unique_public_compound_ids": 31,
|
| "unique_smiles": 31,
|
| "unique_names": 31,
|
| "condition_roles": {
|
| "compound_treatment": 31107
|
| }
|
| },
|
| "ZIC005-2": {
|
| "unique_public_compound_ids": 0,
|
| "unique_smiles": 0,
|
| "unique_names": 1,
|
| "condition_roles": {
|
| "capture_only": 7891
|
| }
|
| }
|
| },
|
| "cell_lines": {
|
| "list": [
|
| "HEK293-clone",
|
| "A549",
|
| "H1650",
|
| "HEK293",
|
| "THP1",
|
| "AEC7"
|
| ],
|
| "count": 6
|
| },
|
| "libraries_per_cell_line": {
|
| "HEK293-clone": {
|
| "libraries": [
|
| "ZIC008",
|
| "ZEL026-2"
|
| ],
|
| "count": 2
|
| },
|
| "A549": {
|
| "libraries": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZEL031",
|
| "ZEL028-2",
|
| "ZIC006",
|
| "ZIC004"
|
| ],
|
| "count": 6
|
| },
|
| "H1650": {
|
| "libraries": [
|
| "ZIC008",
|
| "ZEL031",
|
| "ZEL028-2",
|
| "ZEL024",
|
| "ZIC003",
|
| "ZIC005",
|
| "ZIC002",
|
| "ZIC001",
|
| "ZEL026-2",
|
| "ZIC006",
|
| "ZIC004",
|
| "ZIC007"
|
| ],
|
| "count": 12
|
| },
|
| "HEK293": {
|
| "libraries": [
|
| "ZIC008",
|
| "ZEL028-2",
|
| "ZEL024",
|
| "ZIC002",
|
| "ZIC001",
|
| "ZIC003"
|
| ],
|
| "count": 6
|
| },
|
| "THP1": {
|
| "libraries": [
|
| "ZEL031",
|
| "ZIC004",
|
| "ZIC006",
|
| "ZIC003",
|
| "ZIC002",
|
| "ZIC001",
|
| "ZIC007",
|
| "ZIC005"
|
| ],
|
| "count": 8
|
| },
|
| "AEC7": {
|
| "libraries": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC009",
|
| "ZIC005-2"
|
| ],
|
| "count": 4
|
| }
|
| },
|
| "devices": {
|
| "list": [
|
| 0,
|
| 1,
|
| 2,
|
| 3,
|
| 4,
|
| 5,
|
| 6,
|
| 7,
|
| 8,
|
| 9,
|
| 10,
|
| 11,
|
| 12,
|
| 13,
|
| 14,
|
| 15,
|
| 16,
|
| 17,
|
| 18,
|
| 19,
|
| 20,
|
| 21,
|
| 22,
|
| 23,
|
| 24,
|
| 25,
|
| 26,
|
| 27,
|
| 28,
|
| 29,
|
| 30,
|
| 31,
|
| 32,
|
| 33,
|
| 34,
|
| 35,
|
| 36,
|
| 37,
|
| 38,
|
| 39,
|
| 40,
|
| 41,
|
| 42,
|
| 43,
|
| 44,
|
| 45,
|
| 46,
|
| 47,
|
| 48
|
| ],
|
| "count": 49
|
| },
|
| "device_cell_lines": {
|
| "0": [
|
| "HEK293"
|
| ],
|
| "1": [
|
| "HEK293"
|
| ],
|
| "2": [
|
| "HEK293"
|
| ],
|
| "3": [
|
| "HEK293"
|
| ],
|
| "4": [
|
| "HEK293"
|
| ],
|
| "5": [
|
| "HEK293"
|
| ],
|
| "6": [
|
| "H1650"
|
| ],
|
| "7": [
|
| "H1650"
|
| ],
|
| "8": [
|
| "H1650"
|
| ],
|
| "9": [
|
| "H1650"
|
| ],
|
| "10": [
|
| "THP1"
|
| ],
|
| "11": [
|
| "A549"
|
| ],
|
| "12": [
|
| "THP1"
|
| ],
|
| "13": [
|
| "A549"
|
| ],
|
| "14": [
|
| "A549"
|
| ],
|
| "15": [
|
| "A549"
|
| ],
|
| "16": [
|
| "A549"
|
| ],
|
| "17": [
|
| "A549"
|
| ],
|
| "18": [
|
| "A549"
|
| ],
|
| "19": [
|
| "H1650"
|
| ],
|
| "20": [
|
| "H1650"
|
| ],
|
| "21": [
|
| "A549"
|
| ],
|
| "22": [
|
| "A549"
|
| ],
|
| "23": [
|
| "A549"
|
| ],
|
| "24": [
|
| "H1650"
|
| ],
|
| "25": [
|
| "A549"
|
| ],
|
| "26": [
|
| "H1650"
|
| ],
|
| "27": [
|
| "HEK293"
|
| ],
|
| "28": [
|
| "HEK293"
|
| ],
|
| "29": [
|
| "HEK293-clone"
|
| ],
|
| "30": [
|
| "HEK293-clone"
|
| ],
|
| "31": [
|
| "HEK293"
|
| ],
|
| "32": [
|
| "HEK293"
|
| ],
|
| "33": [
|
| "AEC7"
|
| ],
|
| "34": [
|
| "AEC7"
|
| ],
|
| "35": [
|
| "AEC7"
|
| ],
|
| "36": [
|
| "AEC7"
|
| ],
|
| "37": [
|
| "AEC7"
|
| ],
|
| "38": [
|
| "AEC7"
|
| ],
|
| "39": [
|
| "AEC7"
|
| ],
|
| "40": [
|
| "AEC7"
|
| ],
|
| "41": [
|
| "AEC7"
|
| ],
|
| "42": [
|
| "AEC7"
|
| ],
|
| "43": [
|
| "AEC7"
|
| ],
|
| "44": [
|
| "AEC7"
|
| ],
|
| "45": [
|
| "AEC7"
|
| ],
|
| "46": [
|
| "AEC7"
|
| ],
|
| "47": [
|
| "AEC7"
|
| ],
|
| "48": [
|
| "AEC7"
|
| ]
|
| },
|
| "is_each_device_single_cell_line": true,
|
| "device_libraries": {
|
| "0": [
|
| "ZEL024",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "1": [
|
| "ZEL024",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "2": [
|
| "ZEL024",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "3": [
|
| "ZEL024",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "4": [
|
| "ZEL024",
|
| "ZIC003",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "5": [
|
| "ZEL024",
|
| "ZIC003",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "6": [
|
| "ZEL024",
|
| "ZIC002",
|
| "ZIC005",
|
| "ZIC001",
|
| "ZIC003"
|
| ],
|
| "7": [
|
| "ZEL024",
|
| "ZIC003",
|
| "ZIC005",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "8": [
|
| "ZEL026-2",
|
| "ZIC007",
|
| "ZIC004",
|
| "ZIC006",
|
| "ZIC003",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "9": [
|
| "ZEL026-2",
|
| "ZIC006",
|
| "ZIC003",
|
| "ZIC004",
|
| "ZIC002",
|
| "ZIC001",
|
| "ZIC007"
|
| ],
|
| "10": [
|
| "ZIC006",
|
| "ZEL031",
|
| "ZIC007",
|
| "ZIC004",
|
| "ZIC005",
|
| "ZIC002",
|
| "ZIC003",
|
| "ZIC001"
|
| ],
|
| "11": [
|
| "ZIC006",
|
| "ZIC004"
|
| ],
|
| "12": [
|
| "ZEL031",
|
| "ZIC004",
|
| "ZIC006",
|
| "ZIC003",
|
| "ZIC002",
|
| "ZIC001"
|
| ],
|
| "13": [
|
| "ZIC008",
|
| "ZEL031"
|
| ],
|
| "14": [
|
| "ZIC008",
|
| "ZEL031"
|
| ],
|
| "15": [
|
| "ZIC008",
|
| "ZEL031"
|
| ],
|
| "16": [
|
| "ZIC008",
|
| "ZEL031"
|
| ],
|
| "17": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC004"
|
| ],
|
| "18": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC004"
|
| ],
|
| "19": [
|
| "ZIC008",
|
| "ZEL031"
|
| ],
|
| "20": [
|
| "ZIC008",
|
| "ZEL031"
|
| ],
|
| "21": [
|
| "ZEL026-2",
|
| "ZIC008"
|
| ],
|
| "22": [
|
| "ZIC008",
|
| "ZEL026-2"
|
| ],
|
| "23": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "24": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "25": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "26": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "27": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "28": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "29": [
|
| "ZIC008",
|
| "ZEL026-2"
|
| ],
|
| "30": [
|
| "ZIC008",
|
| "ZEL026-2"
|
| ],
|
| "31": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "32": [
|
| "ZIC008",
|
| "ZEL028-2"
|
| ],
|
| "33": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC009"
|
| ],
|
| "34": [
|
| "ZEL026-2",
|
| "ZIC008",
|
| "ZIC009"
|
| ],
|
| "35": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC009"
|
| ],
|
| "36": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC009"
|
| ],
|
| "37": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC009"
|
| ],
|
| "38": [
|
| "ZEL026-2",
|
| "ZIC008",
|
| "ZIC009"
|
| ],
|
| "39": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC009"
|
| ],
|
| "40": [
|
| "ZIC008",
|
| "ZEL026-2",
|
| "ZIC009"
|
| ],
|
| "41": [
|
| "ZIC008",
|
| "ZIC005-2",
|
| "ZIC009"
|
| ],
|
| "42": [
|
| "ZIC008",
|
| "ZIC009",
|
| "ZIC005-2"
|
| ],
|
| "43": [
|
| "ZIC008",
|
| "ZIC005-2",
|
| "ZIC009"
|
| ],
|
| "44": [
|
| "ZIC008",
|
| "ZIC005-2",
|
| "ZIC009"
|
| ],
|
| "45": [
|
| "ZIC008",
|
| "ZIC005-2",
|
| "ZIC009"
|
| ],
|
| "46": [
|
| "ZIC008",
|
| "ZIC005-2",
|
| "ZIC009"
|
| ],
|
| "47": [
|
| "ZIC008",
|
| "ZIC009",
|
| "ZIC005-2"
|
| ],
|
| "48": [
|
| "ZIC008",
|
| "ZIC005-2",
|
| "ZIC009"
|
| ]
|
| },
|
| "is_each_device_single_library": false,
|
| "device_condition_roles": {
|
| "0": {
|
| "building_block_treatment": 25310,
|
| "compound_treatment": 2051
|
| },
|
| "1": {
|
| "building_block_treatment": 20398,
|
| "compound_treatment": 1613
|
| },
|
| "2": {
|
| "building_block_treatment": 30307,
|
| "compound_treatment": 2599
|
| },
|
| "3": {
|
| "building_block_treatment": 28064,
|
| "compound_treatment": 2454
|
| },
|
| "4": {
|
| "building_block_treatment": 26973,
|
| "compound_treatment": 3040
|
| },
|
| "5": {
|
| "building_block_treatment": 22688,
|
| "compound_treatment": 2578
|
| },
|
| "6": {
|
| "building_block_treatment": 19253,
|
| "compound_treatment": 846
|
| },
|
| "7": {
|
| "building_block_treatment": 2292,
|
| "compound_treatment": 263
|
| },
|
| "8": {
|
| "capture_only": 10369,
|
| "compound_treatment": 2053
|
| },
|
| "9": {
|
| "capture_only": 6717,
|
| "compound_treatment": 854
|
| },
|
| "10": {
|
| "building_block_treatment": 2837,
|
| "compound_treatment": 911
|
| },
|
| "11": {
|
| "compound_treatment": 257
|
| },
|
| "12": {
|
| "building_block_treatment": 19105,
|
| "compound_treatment": 4591
|
| },
|
| "13": {
|
| "compound_treatment": 7771,
|
| "building_block_treatment": 5831
|
| },
|
| "14": {
|
| "compound_treatment": 5583,
|
| "building_block_treatment": 4295
|
| },
|
| "15": {
|
| "compound_treatment": 11376,
|
| "building_block_treatment": 5522
|
| },
|
| "16": {
|
| "compound_treatment": 7041,
|
| "building_block_treatment": 5220
|
| },
|
| "17": {
|
| "compound_treatment": 9757,
|
| "capture_only": 3918
|
| },
|
| "18": {
|
| "compound_treatment": 8428,
|
| "capture_only": 2904
|
| },
|
| "19": {
|
| "compound_treatment": 6283,
|
| "building_block_treatment": 107
|
| },
|
| "20": {
|
| "compound_treatment": 13903,
|
| "building_block_treatment": 324
|
| },
|
| "21": {
|
| "compound_treatment": 15125,
|
| "capture_only": 12714
|
| },
|
| "22": {
|
| "compound_treatment": 11058,
|
| "capture_only": 7182
|
| },
|
| "23": {
|
| "building_block_treatment": 20152,
|
| "compound_treatment": 3456
|
| },
|
| "24": {
|
| "building_block_treatment": 12056,
|
| "compound_treatment": 2122
|
| },
|
| "25": {
|
| "building_block_treatment": 22283,
|
| "compound_treatment": 5429
|
| },
|
| "26": {
|
| "building_block_treatment": 14638,
|
| "compound_treatment": 4074
|
| },
|
| "27": {
|
| "building_block_treatment": 14494,
|
| "compound_treatment": 3505
|
| },
|
| "28": {
|
| "building_block_treatment": 12865,
|
| "compound_treatment": 2943
|
| },
|
| "29": {
|
| "compound_treatment": 19951,
|
| "capture_only": 7878
|
| },
|
| "30": {
|
| "compound_treatment": 14309,
|
| "capture_only": 7074
|
| },
|
| "31": {
|
| "building_block_treatment": 20770,
|
| "compound_treatment": 6751
|
| },
|
| "32": {
|
| "building_block_treatment": 17563,
|
| "compound_treatment": 5811
|
| },
|
| "33": {
|
| "compound_treatment": 7910,
|
| "capture_only": 3588
|
| },
|
| "34": {
|
| "compound_treatment": 7340,
|
| "capture_only": 3910
|
| },
|
| "35": {
|
| "compound_treatment": 6075,
|
| "capture_only": 3090
|
| },
|
| "36": {
|
| "compound_treatment": 8004,
|
| "capture_only": 4107
|
| },
|
| "37": {
|
| "compound_treatment": 9358,
|
| "capture_only": 4032
|
| },
|
| "38": {
|
| "compound_treatment": 12360,
|
| "capture_only": 5144
|
| },
|
| "39": {
|
| "compound_treatment": 13801,
|
| "capture_only": 7391
|
| },
|
| "40": {
|
| "compound_treatment": 10753,
|
| "capture_only": 5565
|
| },
|
| "41": {
|
| "compound_treatment": 2587,
|
| "capture_only": 342
|
| },
|
| "42": {
|
| "compound_treatment": 3990,
|
| "capture_only": 670
|
| },
|
| "43": {
|
| "compound_treatment": 9698,
|
| "capture_only": 1839
|
| },
|
| "44": {
|
| "compound_treatment": 8618,
|
| "capture_only": 1854
|
| },
|
| "45": {
|
| "compound_treatment": 6209,
|
| "capture_only": 1014
|
| },
|
| "46": {
|
| "compound_treatment": 7242,
|
| "capture_only": 1016
|
| },
|
| "47": {
|
| "compound_treatment": 5136,
|
| "capture_only": 847
|
| },
|
| "48": {
|
| "compound_treatment": 3474,
|
| "capture_only": 309
|
| }
|
| },
|
| "no_compound_control_summary": {
|
| "devices_with_capture_only": {
|
| "list": [
|
| 8,
|
| 9,
|
| 17,
|
| 18,
|
| 21,
|
| 22,
|
| 29,
|
| 30,
|
| 33,
|
| 34,
|
| 35,
|
| 36,
|
| 37,
|
| 38,
|
| 39,
|
| 40,
|
| 41,
|
| 42,
|
| 43,
|
| 44,
|
| 45,
|
| 46,
|
| 47,
|
| 48
|
| ],
|
| "count": 24
|
| },
|
| "devices_with_building_block_treatment": {
|
| "list": [
|
| 0,
|
| 1,
|
| 2,
|
| 3,
|
| 4,
|
| 5,
|
| 6,
|
| 7,
|
| 10,
|
| 12,
|
| 13,
|
| 14,
|
| 15,
|
| 16,
|
| 19,
|
| 20,
|
| 23,
|
| 24,
|
| 25,
|
| 26,
|
| 27,
|
| 28,
|
| 31,
|
| 32
|
| ],
|
| "count": 24
|
| }
|
| }
|
| };
|
| const crosstab = {
|
| "ZEL024": {
|
| "A549": 0,
|
| "AEC7": 0,
|
| "H1650": 21545,
|
| "HEK293": 153740,
|
| "HEK293-clone": 0,
|
| "THP1": 0
|
| },
|
| "ZEL026-2": {
|
| "A549": 26718,
|
| "AEC7": 36827,
|
| "H1650": 17086,
|
| "HEK293": 0,
|
| "HEK293-clone": 14952,
|
| "THP1": 0
|
| },
|
| "ZEL028-2": {
|
| "A549": 42435,
|
| "AEC7": 0,
|
| "H1650": 26694,
|
| "HEK293": 65692,
|
| "HEK293-clone": 0,
|
| "THP1": 0
|
| },
|
| "ZEL031": {
|
| "A549": 20868,
|
| "AEC7": 0,
|
| "H1650": 431,
|
| "HEK293": 0,
|
| "HEK293-clone": 0,
|
| "THP1": 21942
|
| },
|
| "ZIC001": {
|
| "A549": 0,
|
| "AEC7": 0,
|
| "H1650": 1229,
|
| "HEK293": 3858,
|
| "HEK293-clone": 0,
|
| "THP1": 1482
|
| },
|
| "ZIC002": {
|
| "A549": 0,
|
| "AEC7": 0,
|
| "H1650": 806,
|
| "HEK293": 9558,
|
| "HEK293-clone": 0,
|
| "THP1": 635
|
| },
|
| "ZIC003": {
|
| "A549": 0,
|
| "AEC7": 0,
|
| "H1650": 378,
|
| "HEK293": 919,
|
| "HEK293-clone": 0,
|
| "THP1": 583
|
| },
|
| "ZIC004": {
|
| "A549": 122,
|
| "AEC7": 0,
|
| "H1650": 411,
|
| "HEK293": 0,
|
| "HEK293-clone": 0,
|
| "THP1": 1380
|
| },
|
| "ZIC005": {
|
| "A549": 0,
|
| "AEC7": 0,
|
| "H1650": 109,
|
| "HEK293": 0,
|
| "HEK293-clone": 0,
|
| "THP1": 48
|
| },
|
| "ZIC005-2": {
|
| "A549": 0,
|
| "AEC7": 7891,
|
| "H1650": 0,
|
| "HEK293": 0,
|
| "HEK293-clone": 0,
|
| "THP1": 0
|
| },
|
| "ZIC006": {
|
| "A549": 207,
|
| "AEC7": 0,
|
| "H1650": 631,
|
| "HEK293": 0,
|
| "HEK293-clone": 0,
|
| "THP1": 1261
|
| },
|
| "ZIC007": {
|
| "A549": 0,
|
| "AEC7": 0,
|
| "H1650": 452,
|
| "HEK293": 0,
|
| "HEK293-clone": 0,
|
| "THP1": 113
|
| },
|
| "ZIC008": {
|
| "A549": 84952,
|
| "AEC7": 91448,
|
| "H1650": 26382,
|
| "HEK293": 19010,
|
| "HEK293-clone": 34260,
|
| "THP1": 0
|
| },
|
| "ZIC009": {
|
| "A549": 0,
|
| "AEC7": 31107,
|
| "H1650": 0,
|
| "HEK293": 0,
|
| "HEK293-clone": 0,
|
| "THP1": 0
|
| }
|
| };
|
|
|
| function switchTab(tabId) {
|
| document.querySelectorAll('.tab-content').forEach(el => el.classList.remove('active'));
|
| document.querySelectorAll('.tab-btn').forEach(el => el.classList.remove('active'));
|
|
|
| document.getElementById(tabId).classList.add('active');
|
|
|
| const btnText = tabId.replace('tab-', '').toLowerCase();
|
| document.querySelectorAll('.tab-btn').forEach(btn => {
|
| if (btn.innerText.toLowerCase() === btnText || (btnText === 'matrix' && btn.innerText.toLowerCase() === 'screen matrix')) {
|
| btn.classList.add('active');
|
| }
|
| });
|
| }
|
|
|
|
|
| window.onload = function() {
|
|
|
| const ctxCell = document.getElementById('cellLineChart').getContext('2d');
|
| new Chart(ctxCell, {
|
| type: 'bar',
|
| data: {
|
| labels: ['HEK293', 'A549', 'AEC7', 'H1650', 'HEK293-clone', 'THP1'],
|
| datasets: [{
|
| label: 'Nanowells Profiled',
|
| data: [252777, 175302, 167273, 96154, 49212, 27444],
|
| backgroundColor: ['#8b5cf6', '#06b6d4', '#ec4899', '#f97316', '#e5e7eb', '#10b981'],
|
| borderColor: 'rgba(255, 255, 255, 0.1)',
|
| borderWidth: 1,
|
| borderRadius: 8
|
| }]
|
| },
|
| options: {
|
| responsive: true,
|
| maintainAspectRatio: false,
|
| plugins: {
|
| legend: { display: false }
|
| },
|
| scales: {
|
| y: {
|
| grid: { color: 'rgba(255, 255, 255, 0.05)' },
|
| ticks: { color: '#9ca3af', font: { family: 'Outfit' } }
|
| },
|
| x: {
|
| grid: { display: false },
|
| ticks: { color: '#9ca3af', font: { family: 'Outfit', weight: 'bold' } }
|
| }
|
| }
|
| }
|
| });
|
|
|
|
|
| const ctxRole = document.getElementById('roleChart').getContext('2d');
|
| new Chart(ctxRole, {
|
| type: 'doughnut',
|
| data: {
|
| labels: ['OBOC Combinatorial Libraries', 'Named Control Compounds', 'No-Compound Controls'],
|
| datasets: [{
|
| data: [353347, 311341, 103474],
|
| backgroundColor: ['#8b5cf6', '#06b6d4', '#f43f5e'],
|
| borderWidth: 0,
|
| hoverOffset: 10
|
| }]
|
| },
|
| options: {
|
| responsive: true,
|
| maintainAspectRatio: false,
|
| plugins: {
|
| legend: {
|
| position: 'bottom',
|
| labels: {
|
| color: '#e5e7eb',
|
| font: { family: 'Outfit', size: 12 },
|
| padding: 15
|
| }
|
| }
|
| },
|
| cutout: '65%'
|
| }
|
| });
|
|
|
| buildHeatmap();
|
| buildDeviceTable();
|
| buildLibraryCards();
|
| };
|
|
|
|
|
| function buildHeatmap() {
|
| const grid = document.getElementById('heatmapGrid');
|
| const cellLines = ['A549', 'AEC7', 'H1650', 'HEK293', 'HEK293-clone', 'THP1'];
|
|
|
|
|
| grid.appendChild(createDiv('heatmap-header-cell', ''));
|
| cellLines.forEach(cell => {
|
| grid.appendChild(createDiv('heatmap-header-cell', cell));
|
| });
|
|
|
|
|
| Object.keys(crosstab).sort().forEach(lib => {
|
|
|
| grid.appendChild(createDiv('heatmap-label-cell', lib));
|
|
|
|
|
| cellLines.forEach(cell => {
|
| const val = crosstab[lib][cell] || 0;
|
| const cellEl = document.createElement('div');
|
| cellEl.className = 'heatmap-cell';
|
|
|
|
|
| let bg = 'rgba(139, 92, 246, 0.03)';
|
| let color = 'rgba(255, 255, 255, 0.15)';
|
| let border = '1px solid var(--border-color)';
|
|
|
| if (val > 0) {
|
| border = 'none';
|
| if (val < 2000) {
|
| bg = 'rgba(139, 92, 246, 0.25)';
|
| color = '#d8b4fe';
|
| } else if (val < 25000) {
|
| bg = 'rgba(139, 92, 246, 0.55)';
|
| color = '#e9d5ff';
|
| } else {
|
| bg = 'rgba(139, 92, 246, 0.85)';
|
| color = '#ffffff';
|
| }
|
| }
|
|
|
| cellEl.style.background = bg;
|
| cellEl.style.color = color;
|
| cellEl.style.border = border;
|
|
|
| const valSpan = document.createElement('span');
|
| valSpan.className = 'heatmap-cell-value';
|
| valSpan.innerText = val > 0 ? val.toLocaleString() : '-';
|
| cellEl.appendChild(valSpan);
|
|
|
| if (val > 0) {
|
| const pctSpan = document.createElement('span');
|
| pctSpan.className = 'heatmap-cell-pct';
|
| pctSpan.innerText = ((val / 768162) * 100).toFixed(1) + '%';
|
| cellEl.appendChild(pctSpan);
|
| }
|
|
|
| grid.appendChild(cellEl);
|
| });
|
| });
|
| }
|
|
|
| function createDiv(className, text) {
|
| const el = document.createElement('div');
|
| el.className = className;
|
| el.innerText = text;
|
| return el;
|
| }
|
|
|
|
|
| function buildDeviceTable() {
|
| const tbody = document.getElementById('deviceTableBody');
|
| tbody.innerHTML = '';
|
|
|
| const devices = results.devices.list;
|
| devices.forEach(dev => {
|
| const devStr = dev.toString();
|
| const master_c = results.device_cell_lines[devStr][0];
|
|
|
| const libs = results.device_libraries[devStr];
|
| const libsBadges = libs.map(lib => {
|
| let badgeClass = 'badge-purple';
|
| if (lib === 'ZEL026-2') badgeClass = 'badge-rose';
|
| else if (lib === 'ZIC005' || lib === 'ZIC005-2') badgeClass = 'badge-blue';
|
| else if (lib.startsWith('ZEL')) badgeClass = 'badge-cyan';
|
| return `<span class="badge ${badgeClass}" style="margin: 2px;">${lib}</span>`;
|
| }).join(' ');
|
|
|
| const roles = results.device_condition_roles[devStr];
|
| const cellCount = Object.values(roles).reduce((a, b) => a + b, 0);
|
|
|
| const rolesSplit = Object.keys(roles).map(role => {
|
| let colorClass = 'text-muted';
|
| let displayName = role;
|
| if (role === 'building_block_treatment') {
|
| displayName = 'OBOC Library';
|
| colorClass = 'color: #a78bfa;';
|
| } else if (role === 'compound_treatment') {
|
|
|
| if (libs.includes('ZIC005')) {
|
| displayName = 'Named Controls (+Water)';
|
| } else {
|
| displayName = 'Named Controls';
|
| }
|
| colorClass = 'color: #22d3ee;';
|
| } else if (role === 'capture_only') {
|
| displayName = 'No-Compound Control';
|
| colorClass = 'color: #f43f5e;';
|
| }
|
| return `<span style="font-size: 0.8rem; font-family: var(--font-mono); ${colorClass} font-weight:500;">${displayName}: ${roles[role].toLocaleString()}</span>`;
|
| }).join('<br>');
|
|
|
| const tr = document.createElement('tr');
|
| tr.setAttribute('data-device-id', devStr);
|
| tr.setAttribute('data-cell-line-master', master_c);
|
| tr.setAttribute('data-libraries', libs.join(','));
|
|
|
| tr.innerHTML = `
|
| <td style="font-family: var(--font-mono); font-weight:bold; padding-left: 1.5rem;">#${dev}</td>
|
| <td>${master_c}</td>
|
| <td>${libsBadges}</td>
|
| <td style="font-family: var(--font-mono); font-weight: 500;">${cellCount.toLocaleString()}</td>
|
| <td>${rolesSplit}</td>
|
| `;
|
| tbody.appendChild(tr);
|
| });
|
| }
|
|
|
|
|
| function filterDevices() {
|
| const q = document.getElementById('deviceSearch').value.toLowerCase();
|
| const cellFilter = document.getElementById('cellLineFilter').value;
|
|
|
| const rows = document.querySelectorAll('#deviceTableBody tr');
|
| rows.forEach(row => {
|
| const devId = row.getAttribute('data-device-id');
|
| const masterCell = row.getAttribute('data-cell-line-master');
|
| const libs = row.getAttribute('data-libraries').toLowerCase();
|
|
|
| const matchQuery = devId.includes(q) || masterCell.toLowerCase().includes(q) || libs.includes(q);
|
| const matchCell = !cellFilter || masterCell === cellFilter;
|
|
|
| if (matchQuery && matchCell) {
|
| row.style.display = '';
|
| } else {
|
| row.style.display = 'none';
|
| }
|
| });
|
| }
|
|
|
|
|
| function buildLibraryCards() {
|
| const grid = document.getElementById('libGrid');
|
| grid.innerHTML = '';
|
|
|
| Object.keys(results.compounds_per_library).sort().forEach(lib => {
|
| const details = results.compounds_per_library[lib];
|
| const card = document.createElement('div');
|
| card.className = 'lib-card';
|
|
|
|
|
| const sumCells = Object.values(details.condition_roles).reduce((a,b)=>a+b, 0);
|
|
|
|
|
| let categoryLabel = '';
|
| let badgeClass = 'badge-purple';
|
| if (lib === 'ZEL026-2') {
|
| categoryLabel = 'No-Compound Control Beads';
|
| badgeClass = 'badge-rose';
|
| } else if (lib === 'ZIC005' || lib === 'ZIC005-2') {
|
| categoryLabel = lib === 'ZIC005' ? 'No-Compound Control (Water)' : 'No-Compound Control';
|
| badgeClass = 'badge-blue';
|
| } else if (lib.startsWith('ZEL')) {
|
| categoryLabel = 'OBOC Combinatorial Library';
|
| badgeClass = 'badge-cyan';
|
| } else if (lib.startsWith('ZIC')) {
|
| categoryLabel = 'Named Control Compounds';
|
| badgeClass = 'badge-purple';
|
| }
|
|
|
| let roleBadge = `<span class="badge ${badgeClass}">${categoryLabel}</span>`;
|
|
|
| card.innerHTML = `
|
| <div>
|
| <div class="lib-name">
|
| <span>${lib}</span>
|
| ${roleBadge}
|
| </div>
|
| <div style="margin-top: 1rem;">
|
| <div class="lib-details-row">
|
| <span class="lib-details-label">Unique Compound IDs</span>
|
| <span class="lib-details-val">${details.unique_public_compound_ids.toLocaleString()}</span>
|
| </div>
|
| <div class="lib-details-row">
|
| <span class="lib-details-label">Unique SMILES Structure Maps</span>
|
| <span class="lib-details-val">${details.unique_smiles.toLocaleString()}</span>
|
| </div>
|
| <div class="lib-details-row">
|
| <span class="lib-details-label">Unique Names</span>
|
| <span class="lib-details-val">${details.unique_names.toLocaleString()}</span>
|
| </div>
|
| <div class="lib-details-row">
|
| <span class="lib-details-label">Total Profiled Nanowells</span>
|
| <span class="lib-details-val" style="color: #fff;">${sumCells.toLocaleString()}</span>
|
| </div>
|
| </div>
|
| </div>
|
| `;
|
| grid.appendChild(card);
|
| });
|
| }
|
| </script>
|
| </body>
|
| </html>
|
|
|
