Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
ABC2-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
Study of the possible role of interleukin-6 (IL-6) on embryo implantation in mice | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | ||
Metal atom incorporation studies on AxMo6S8 Chevrel phases | Solid State Communications | [
"Materials Chemistry",
"Condensed Matter Physics"
] | |
Correction to “Characterizing the Oil-like and Surfactant-like Behavior of Polar Oils” | [
"Electrochemistry",
"Spectroscopy",
"Surfaces and Interfaces",
"Condensed Matter Physics"
] | ||
A novel Col4A1 mutation: recognizing an uncommon cause of stroke | [
"Neurology (clinical)",
"Neurology"
] | ||
Effect of "Most-Favoured-Nation" Clause in Commercial Treaties | [
"Law"
] | ||
Uromodulin-related autosomal-dominant tubulointerstitial kidney disease—pathogenetic insights based on a case | [
"Transplantation",
"Nephrology"
] | ||
Baller-Gerold syndrome: Further evidence for association with prenatal exposure to valproate | Annals of Indian Academy of Neurology | [
"Neurology (clinical)"
] | |
The Qur'anic Narratives of the Golden Calf Episode | The ‘golden calf’ episode is discussed in verses Q.20:83-98 and Q.7:148-151. In addition to this there are two short versions in Q.2:51, 54, 92-3 and Q4:153. The same topic also appears in the Bible in Exodus 32. Though the two scriptures' accounts have some points in common they vary in their approaches: the main purposes of the story, the style and tone adopted by the Narrator, its time-span and so on are quite different. This article presents a discussion of the aforementioned Qur'anic narrative. Amongst other things, it approaches the story of Moses and the golden calf systematically, linguistically as well as historically, contrasting its depiction in the Qur'an to that in the Bible. The author also examines interpretations of the relevant verses and/or narrative by both classical and modern exegetes, in order to facilitate a deeper understanding of the Qur'anic presentation of this specific episode. | [
"Religious Studies"
] | |
Deactivation of nickel catalysts by sulphur compounds | [
"Process Chemistry and Technology",
"Catalysis"
] | ||
Norms: An Integrated Framework | Norms are a foundational concept in sociology. Following a period of skepticism about norms as overly deterministic and as paying too little attention to social conflict, inequalities, and agency, the past 20 years have seen a proliferation of norms research across the social sciences. Here we focus on the burgeoning research in sociology to answer questions about where norms come from, why people enforce them, and how they are applied. To do so, we rely on three key theoretical approaches in the literature—consequentialist, relational, and agentic. As we apply these approaches, we explore their implications for what are arguably the two most fundamental issues in sociology—social order and inequality. We conclude by synthesizing and building on existing norms research to produce an integrated theoretical framework that can shed light on aspects of norms that are currently not well understood—in particular, their change and erosion. | [
"Sociology and Political Science"
] | |
Invariant knots of free involutions of S4 | [
"Geometry and Topology"
] | ||
Mitteilungen des BV Geriatrie | [
"Geriatrics and Gerontology",
"Gerontology",
"Health (social science)",
"Issues, Ethics and Legal Aspects"
] | ||
Complement Activation Correlates With Disease Severity and Contributes to Cytokine Responses inPlasmodium falciparumMalaria | [
"Infectious Diseases",
"Immunology and Allergy"
] | ||
Social support, perceptions of attractiveness, weight, and the CPI in socially anxious males and females | [
"Arts and Humanities (miscellaneous)",
"Clinical Psychology"
] | ||
Changes in the Immune Functions during ALL Induction Therapy - Prospective Immune Monitoring in 23 Children. | Abstract Introduction: Inadequate lymphocyte functions are an important clinical problem complicating chemotherapy by severe bacterial and fungal infections. During an ongoing immune response, cytokines produced by T-cells are critical to the effectiveness of that response. To understand what happens with the immune system in the beginning of therapy, we investigated lymphocyte subpopulations and functioning (cytokines, immunoglobulins). Patients: 23 children (median age 5y;range 2m-14y;15 female, 8 male) with B precursor ALL were treated according to the ALL-BFM 2000 protocol. Blood samples were drawn at diagnosis and on days 8, 15, 33 and 64 and before beginning of protocol M, protocol 2 and during maintenance therapy. Methods: We analyzed lymphocyte subpopulations using flow cytometry. Intracellular cytokines (IFNg, IL2, TNFa, IL4, IL5, and IL10) were determined by FACS after in vitro stimulation with PMA, ionomycin and brefeldin for 24h. Additionally, we measured various cytokines in unstimulated sera by ELISA. Furthermore, we studied TRECs and Spectratype values and immunoglobulins. Results: As to lymphocyte subpopulations, B-cells decreased rapidly from a median value of 301+120/mm_ before chemotherapy to 85+138/mm_ during chemotherapy (“day 33”) and did not reappear until the end of therapy. T cells decreased at the beginning of chemotherapy, but there was a partial recovery proportional to the intensity of chemotherapy. Also we found a shift towards CD8+ cells. NK cells did not show significant changes. As to cytokines in CD3+ T-cells, we detected an increase of IFNg (diagnosis:11+9%, day 33: 22+7%). We could detect a correlation between gd-TCR and IFNg production (FACS) as well as IFNg values (ELISA) and high memory cell count. Also CD45RA+cells correlate with CD4IL2+cells. Finally TGFb in unstimulated sera correlated strongly (p<0,01) with CD19+cells. TGFb was also produced by blasts. We detected difference in cytokine profile between conditioning with dexamethasone vs. prednisone, especially the IFNg secretion was much higher in the prednisone branch (p<0,01). TREC values were higher in the dexamethason branch, but this might be due to the age, because younger children had significantly higher TREC values. Analyses of TCR repertoire show a slightly higher complexity in the prednisone branch. Until d15 the repertoire complexities were reduced and increase slowly continuingly during therapy. We could detect Vb gene families with high complexity during the whole therapy (for example BV22, BV23) and with low complexity (BV13b, BV6a). The complexity correlated positively with the number of naïve T-cells and with the age (p<0,01). Summary: We detected a shift towards Th1-cytokines during ALL-induction-therapy. B cells were erased during chemotherapy. This might be of clinical importance of the possible necessity of prophylactic immunoglobulins to prevent serious infection because of the lack of B-cells. | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] | |
TCTAP A-027 Panax Notoginseng Saponins Safely Boost Cardiac Function and Anti-apoptosis in a Myocardial Infarction Model in the Rat via the MEK/ERK Pathway | Journal of the American College of Cardiology | [
"Cardiology and Cardiovascular Medicine"
] | |
Ultrafast dynamics of charge transfer in CVD grown MoS2–graphene heterostructure | [
"Physics and Astronomy (miscellaneous)"
] | ||
Lexique de la Regula Magistri | [
"Linguistics and Language",
"History",
"Language and Linguistics",
"Cultural Studies",
"Archeology",
"Religious Studies"
] | ||
Experimental study of temperature dependence of drilling fluids viscosity with nanoparticles | Abstract This research is focused on the dependence of viscosity of water-based drilling fluid modified by nanoparticles on temperature. Silicon oxide of 10 nm size was used as nanoparticles. The nanosuspensions were prepared for nanoparticle concentrations from 0.25 to 3 wt%. An aqueous solution of bentonite with a mass fraction of 5 % was used as a base drilling fluid. Rheological studies were conducted at varying temperatures (25, 40, 55 and 80 °C). The dependences of the effective viscosity of these suspensions on the concentration of nanoparticles and temperature have been obtained. | [
"Computer Science Applications",
"History",
"Education"
] | |
INTRACELLULAR SURFACTANT REMOVAL FROM PHAGOCYTIZED MINERALS: Development of a Fluorescent Method Using a BODIPY-Labeled Phospholipid | Inhalation Toxicology | [
"Health, Toxicology and Mutagenesis",
"Toxicology"
] | |
First report of intersex in a lutjanid: the goldband snapper Pristipomoides multidens | [
"Aquatic Science",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Effects of dexamethasone on the levels of adrenal steroidogenic enzyme mRNA in rats treated with 4-aminopyrazolopyrimidine | Molecular and Cellular Endocrinology | [
"Endocrinology",
"Molecular Biology",
"Biochemistry"
] | |
Global stability analysis for stochastic coupled reaction–diffusion systems on networks | [
"Applied Mathematics",
"Computational Mathematics",
"Analysis"
] | ||
Innate immunity and genetic determinants of urinary tract infection susceptibility | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
An Innovative Approach for the Generation of Species of the Interstellar Medium | Angewandte Chemie International Edition | [
"Catalysis"
] | |
Evolutionary Conservation Genomics Reveals Recent Speciation and Local Adaptation in Threatened Takins | AbstractIncorrect species delimitation will lead to inappropriate conservation decisions, especially for threatened species. The takin (Budorcas taxicolor) is a large artiodactyl endemic to the Himalayan–Hengduan–Qinling Mountains and is well known for its threatened status and peculiar appearance. However, the speciation, intraspecies taxonomy, evolutionary history, and adaptive evolution of this species still remain unclear, which greatly hampers its scientific conservation. Here, we de novo assembled a high-quality chromosome-level genome of takin and resequenced the genomes of 75 wild takins. Phylogenomics revealed that takin was positioned at the root of Caprinae. Population genomics based on the autosome, X chromosome, and Y chromosome SNPs and mitochondrial genomes consistently revealed the existence of two phylogenetic species and recent speciation in takins: the Himalayan takin (B. taxicolor) and the Chinese takin (B. tibetana), with the support of morphological evidence. Two genetically divergent subspecies were identified in both takin species, rejecting three previously proposed taxonomical viewpoints. Furthermore, their distribution boundaries were determined, suggesting that large rivers play important roles in shaping the genetic partition. Compared with the other subspecies, the Qinling subspecies presented the lowest genomic diversity, higher linkage disequilibrium, inbreeding, and genetic load, thus is in urgent need of genetic management and protection. Moreover, coat color gene (PMEL) variation may be responsible for the adaptive coat color difference between the two species following Gloger’s rule. Our findings provide novel insights into the recent speciation, local adaptation, scientific conservation of takins, and biogeography of the Himalaya–Hengduan biodiversity hotspot. | [
"Genetics",
"Molecular Biology",
"Ecology, Evolution, Behavior and Systematics"
] | |
Triacetyluridine treats epileptic encephalopathy fromCADmutations: a case report and review | Annals of Clinical and Translational Neurology | [
"Neurology (clinical)"
] | |
Wavelet based feature extraction of voltage profile for online voltage stability assessment using RBF neural network | [
"Electrical and Electronic Engineering",
"Energy Engineering and Power Technology"
] | ||
Blood Staining of the Cornea Following Radial Keratotomy | Journal of Refractive Surgery | [
"Ophthalmology",
"Surgery"
] | |
POLITICAL MORALITY AS CONVENTION | A remarkable feature of contemporary political discourse is the dominance of morality. One legacy of logical positivism (which was dominant from the mid-1930s until the end of the 1960s) and analytical (or linguistic) philosophy was the reluctance of political theorists during the twentieth century to engage in substantive argument about appropriate social ends or individual rights and values. Philosophers were content to describe the linguistic framework within which related political proposals were discussed without offering any proposals themselves. It was felt that the philosopher was not especially qualified to give political advice or make any recommendations. The technical political theorist was properly confined to the second level of inquiry, that is, explanation of the meaning of concepts, not the first level, which was concerned with questions of how we ought to live, or issues of public policy. Economists and sociologists might have the technical skills appropriate for inquiries into public policy, but as to the big questions—such as the ends and purposes of man and society—almost anybody could make pronouncements. The important point was that reason was incapable of adjudicating between rival versions of the good life. | [
"Philosophy"
] | |
Comparison of PLS algorithms when number of objects is much larger than number of variables | [
"Statistics, Probability and Uncertainty",
"Statistics and Probability"
] | ||
A case of Sjögren syndrome suspected, rheumatoid arthritis and Behcet's disease complicated with cochlear nerve and trigeminal nerve disorders | [
"Immunology",
"Immunology and Allergy"
] | ||
Divalent metal ion catalyzed reactions of acyl phosphates | [
"Colloid and Surface Chemistry",
"Biochemistry",
"Catalysis"
] | ||
Effects of Vitamin D Supplementation on Bone Mineral Density and Bone Markers in HIV-Infected Youth | [
"Pharmacology (medical)",
"Infectious Diseases"
] | ||
Computer simulation of xenon dimer formation in a dense inert-gas environment | [
"Physical and Theoretical Chemistry"
] | ||
Model of the Wear of Rubber under Direct Impact by a Stream of Solid Particles | [
"Polymers and Plastics"
] | ||
FISH-SCHURMAN CORPORATION | [
"Analytical Chemistry"
] | ||
Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line | Molecular and Cellular Biology | [
"Cell Biology",
"Molecular Biology"
] | |
Understanding the Mental Health of Transgender and Nonbinary Youth | Journal of Adolescent Health | [
"Psychiatry and Mental Health",
"Public Health, Environmental and Occupational Health",
"Pediatrics, Perinatology and Child Health"
] | |
Cancer | [
"Cancer Research",
"Oncology"
] | ||
THE ASSOCIATED PRODUCTION OF THE NEUTRAL TOP-PION WITH A PAIR OF THIRD FAMILY QUARKS AT THE HADRON COLLIDERS | We study the associated production of the neutral top-pion [Formula: see text] with the third family quarks within the context of the topcolor-assisted technicolor model at the hadron colliders. The studies show that, at the Tevatron, the cross-sections of all these processes are too small to produce enough identified signals. But the cross-sections can be largely enhanced at the LHC. Specially for the processes [Formula: see text] and [Formula: see text], the cross-sections can reach the level of a few hundred fb even a few pb for the light neutral top-pion. With the high yearly luminosity 100 fb-1 at the LHC, over 104 signals can be produced via the above two processes. There exists an ideal flavor-changing mode to detect neutral top-pion, i.e. [Formula: see text], because the SM background of such production mode are very clean. Therefore, we can conclude that neutral top-pion should be observable at the LHC via the processes [Formula: see text] and [Formula: see text]. On the other hand, the statistics available at the LHC via these two processes might be enough to measure the Yukawa couplings [Formula: see text] and [Formula: see text]. Finally, it must be noted that the study of the process [Formula: see text] can give us a good chance to distinguish the TC2 model from the SM and MSSM because there does not exist such similar tree-level favor-changing process in these models. | [
"Astronomy and Astrophysics",
"Nuclear and High Energy Physics"
] | |
Masthead: (Adv. Mater. 2/2015) | [
"Mechanical Engineering",
"Mechanics of Materials"
] | ||
Johannes ZACHHUBER, Human Nature in Gregory of Nyssa: Philosophical Background and Theological Significance, IX, Brill, Leiden 2000, 271 pp., 14 x 25, ISBN 90-04-11530-7. | [
"Religious Studies"
] | ||
Ann Keen MP: a district nurse at the heart of government | Ann Keen’s career has, over 25 years, spanned nursing, education and politics. She’s now MP for Brentford and Isleworth and Parliamentary Private Secretary to Gordon Brown, the Chancellor of the Exchequer. ‘I’ve got the best job in parliament,’ she says. ‘I’m right at the heart of government.’ | [
"Community and Home Care"
] | |
Shame aversion therapy | [
"Psychiatry and Mental Health",
"Arts and Humanities (miscellaneous)",
"Clinical Psychology",
"Experimental and Cognitive Psychology"
] | ||
Improvement of Fracture Toughness of Stainless Steel Adhesive Joints at Cryogenic Temperature | [
"Materials Chemistry",
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Mechanics of Materials"
] | ||
Hydrothermal Synthesis of Spherical Li4Ti5O12 as Anode Material for High Power Lithium-Ion Secondary Battery | [
"Physical and Theoretical Chemistry"
] | ||
Research fraud and its combat: what can a journal do? | [
"Education"
] | ||
The fission of heated nuclei in reactions involving heavy ions: static and dynamical aspects | [
"Nuclear and High Energy Physics"
] | ||
Isolation and characterization of microsatellite loci in the Brazilian orchid Epidendrum fulgens | [
"Genetics",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Third international challenge to model the medium- to long-range transport of radioxenon to four Comprehensive Nuclear-Test-Ban Treaty monitoring stations | [
"Health, Toxicology and Mutagenesis",
"Pollution",
"Waste Management and Disposal",
"Environmental Chemistry"
] | ||
DinCH and ESBO actual migration from PVC infusion tubings used in an oncopediatric unit | [
"Materials Chemistry",
"Polymers and Plastics",
"Surfaces, Coatings and Films"
] | ||
On the use of prophylactic antibiotics in prevention of toxic shock syndrome | [
"Critical Care and Intensive Care Medicine",
"Emergency Medicine",
"Surgery"
] | ||
Life in Neolithic Farming Communities: Social Organization, Identity, and Differentiation. I. Kuijt, editor. 2000. (Fundamental Issues in Archaeology). Kluwer Academic/Plenum Publishers, New York. 332 pp. $80.00, ISBN:0-306-46122-6. | [
"Museology",
"Archeology",
"Arts and Humanities (miscellaneous)",
"History"
] | ||
Correlation analysis between myocardial work indices and liver function classification in patients with hepatitis B cirrhosis: A study with non-invasive left ventricular pressure-strain loop | BackgroundLiver cirrhosis is closely associated with cardiac dysfunction. The aims of this study were to evaluate left ventricular systolic function in patients with hepatitis B cirrhosis by non-invasive left ventricular pressure-strain loop (LVPSL) technique, and to explore the correlation between myocardial work indices and liver function classification.MethodsAccording to the Child-Pugh classification, 90 patients with hepatitis B cirrhosis were further divided into three groups: Child-Pugh A group (n = 32), Child-Pugh B group (n = 31), and Child-Pugh C group (n = 27). During the same period, 30 healthy volunteers were recruited as the control (CON) group. Myocardial work parameters, which included global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE), were derived from the LVPSL and compared among the four groups. The correlation between myocardial work parameters and Child-Pugh liver function classification was evaluated, and the independent risk factors affecting left ventricular myocardial work in patients with cirrhosis were investigated by univariable and multivariable linear regression analysis.ResultsGWI, GCW and GWE of Child-Pugh B and C groups were lower than those of CON group, while GWW was higher than that of CON group, and the changes were more obvious in Child-Pugh C group (P < 0.05). Correlation analysis revealed that GWI, GCW, and GWE were negatively correlated with liver function classification to various degrees (r = −0.54, −0.57, and −0.83, respectively, all P < 0.001), while GWW was positively correlated with liver function classification (r = 0.76, P < 0.001). Multivariable linear regression analysis showed that GWE was positively correlated with ALB (β = 0.17, P < 0.001), and negatively correlated with GLS (β = −0.24, P < 0.001).ConclusionsThe changes in the left ventricular systolic function in patients with hepatitis B cirrhosis were identified using non-invasive LVPSL technology, and myocardial work parameters are significantly correlated with liver function classification. This technique may provide a new method for the evaluation of cardiac function in patients with cirrhosis. | [
"Cardiology and Cardiovascular Medicine"
] | |
Acid-Catalyzed Hydration of anti-Sesquinorbornene | The Journal of Organic Chemistry | [
"Organic Chemistry"
] | |
Journal of Electronic Testing | [
"Electrical and Electronic Engineering"
] | ||
Aging and Memory: A Cognitive Approach | This article describes changes in memory during the normal aging process from the standpoint of cognitive psychology. There is now a great deal of evidence to show that memory is not one single function but may be described in terms of different memory systems that show differential effects of aging. For example, memory for procedures, and some perceptual memory functions, show few age-related changes, whereas working memory, episodic memory, and prospective memory decline substantially in the course of normal aging. Memory for facts and knowledge (semantic memory) holds up well in older individuals provided that the information is used frequently, although the ability to retrieve highly specific information (such as names) typically declines. The article discusses current theoretical accounts of the effects of aging; different theorists have attributed the changes in memory and cognition to mental slowing, declining attentional resources, an inability to inhibit unwanted information, and a decline in cognitive control. Other suggestions include the notion that memory performance in older adults is particularly vulnerable when the need for self-initiated processing is greatest; conversely, performance is greatly helped by the provision of environmental support. The practical implications of these research findings and ideas include the point that clinical memory assessments should incorporate tests designed to measure the different aspects of memory functioning. | [
"Psychiatry and Mental Health"
] | |
Peripheral Neuropathy Associated With Anti–Tumor Necrosis Factor Therapy | [
"Rheumatology"
] | ||
Rethinking the relationship between gender and technology: a study of the Indian example | Technology is often associated with masculinity. Much of the literature suggests that computers have also been appropriated as male machines. However, research from developing countries indicates findings to the contrary. This article argues that the relationship between technology and gender is not static. Rather, it alters with the changes in socio-cultural and economic context. Through the Indian example, it shows that the dynamic phase of society and economy has provided a veritable mix of factors that is propelling an upsurge of women in computer-related courses and professions. However, this is not an indication of a radical revolution in gender relations in society. Rather, it encapsulates the transition within developing countries like India and reflects continuity as well as change. Further, the labour market continues to exhibit gender segregation, indicating that the issues pertaining to gender and technology and labour segregation cannot be fused. | [
"Organizational Behavior and Human Resource Management",
"Economics and Econometrics",
"Sociology and Political Science",
"Accounting"
] | |
Underwater Explosion Performance of RDX/AP-based Aluminized Explosives | Central European Journal of Energetic Materials | [
"Materials Chemistry",
"Organic Chemistry"
] | |
A Multiaddressable Dyad with Switchable Cyan/Magenta/Yellow Colors for Full-Color Rewritable Paper | [
"Catalysis",
"Organic Chemistry"
] | ||
Author Index | [
"Immunology",
"Immunology and Allergy"
] | ||
Primary Amenorrhea in an Adolescent Secondary to a Virilizing Luteinized Thecoma of the Ovary | [
"Obstetrics and Gynecology",
"Pediatrics, Perinatology and Child Health"
] | ||
Nontechnical skills in pediatric surgery: Factors influencing operative performance | [
"Pediatrics, Perinatology and Child Health",
"Surgery"
] | ||
Factors Affecting Technology Transfer and Commercialization of University Research in India: a Cross-sectional Study | AbstractIn recent years, there is a great emphasis on transferring inventions and technologies originating from academia to industry through technology transfer/licensing or commercialization. The efforts of the Government of India (GOI) aim to create socially useful innovation through university-industry technology transfer. The objective of the study is to examine and understand enabling factors and barriers for technology transfer among Indian universities. The study covers three key aspects: (1) the awareness and practice of patents and research commercialization among Indian academia, (2) comprehending strategies adapted to commercialize research activities, and (3) barriers in university-industry technology transfer (TT). This paper is an attempt to answer the research question whether current dynamics within Indian universities create an environment for enabling knowledge transfer/commercialization and propose plausible suggestions to enable academia-industry technology transfer. A self- assessed structured methodology is contemplated and applied. Convenience sampling methods were adopted. Administrators of 25 universities overseeing research and development activities/patent cell/incubation cell or industrial collaboration of universities were approached to participate in the study. Indian universities are categorized as (i) public funded universities and (ii) private institutes for the purpose of the study. It is interesting to understand that public funded universities have an advantage in terms of receiving funds and licensing the research to potential industrial partners. The authors further conclude that research undertaken in academia is far from the demands of the industry. Even though the relevant supporting system for enhancing university-industry collaboration is in place, such as establishing technology transfer office (TTO) in the university, they hardly channelize the resources for socially useful innovation. It is important for Indian academia to undertake commercially viable research for the benefit of society. | [
"Economics and Econometrics"
] | |
Review of IES Lighting Handbook. Second Edition. | [
"Applied Psychology"
] | ||
Air pericardial tamponade | The American Journal of Cardiology | [
"Cardiology and Cardiovascular Medicine"
] | |
From Ritual to Record: The Nature of Modern Sports | [
"Museology",
"Archeology",
"History"
] | ||
Development of a sustainable livelihood security model for storm-surge hazard in the coastal areas of Bangladesh | [
"Safety, Risk, Reliability and Quality",
"Water Science and Technology",
"Environmental Chemistry",
"Environmental Engineering"
] | ||
A Person-Centered Approach to Students' Evaluations of Perceived Fear Appeals and Their Association With Engagement | The Journal of Experimental Education | [
"Developmental and Educational Psychology",
"Education"
] | |
Cemiplimab (REGN2810): A fully human anti-PD-1 monoclonal antibody for patients with unresectable locally advanced or metastatic cutaneous squamous cell carcinoma (CSCC)—Initial safety and efficacy from expansion cohorts (ECs) of phase I study. | 195 Background: There is no established standard of care for unresectable locally advanced or metastatic CSCC. UV-induced DNA damage causes hypermutation in most CSCCs. Therefore, these tumors may be responsive to PD-1 checkpoint blockade. In the dose escalation portion of the phase 1 study of cemiplimab (REGN2810), a durable (19 + months) radiologic complete response was observed in a patient (pt) with metastatic CSCC (ASCO 2015, #3024). Methods: ECs enrolled pts with distantly metastatic (EC 7) and locally advanced (EC 8) CSCC. All patients received cemiplimab 3 mg/kg by intravenous infusion over 30 minutes every 2 weeks for up to 48 weeks. Research biopsies were performed at baseline and Day 29 (and at progression, if possible). Tumor measurements were performed every 8 weeks according to RECIST 1.1 to determine overall response rate (ORR). Data cutoff date was 31 Jan 2017. Results: 26 pts were enrolled (10 in EC 7 and 16 in EC 8): median age, 72.5 y (range, 56–88y); median PS 1 (range, 0–1); 21M:5F; median number of prior systemic therapy regimens, 1 (range, 0–2). Median exposure to cemiplimab was 7 doses (range, 1–22). The most common treatment-related adverse event of any grade was fatigue (19.2%). Each of the following ≥ Grade 3 related AEs occurred once: AST elevation, ALT elevation, arthralgia, and rash. ORR (PR + CR, including unconfirmed) and disease control rate (ORR+SD) were 52% (12/23; 4uPR, 5 PR, 2CR, 1 uCR) and 70% (16/23, including 4SD), respectively. Three patients are not yet evaluable. Median PFS and OS have not been reached, and only one patient has experienced PD during cemiplimab treatment after initial response. Correlative studies are in process, including PD-L1 status and whole exome tumor DNA sequencing. Conclusions: Cemiplimab is well tolerated and produces antitumor activity in patients with advanced CSCC. A pivotal trial of cemiplimab for patients with advanced CSCC is enrolling patients. Clinical trial information: NCT02383212. | [
"Cancer Research",
"Oncology"
] | |
Dealing with nonresponse: Strategies to increase participation and methods for postsurvey adjustments | [
"Geography, Planning and Development",
"Demography"
] | ||
With the Newsroom at Home: Routines and Tensions of Women Journalists in Times of Covid-19 | This article identifies the routines and working practices of women journalists from Colombia and Venezuela in the framework of the health emergency caused by covid-19 in the countries where they work. It is a quantitative research at a descriptive cross-sectional level in which an instrument made up of 26 questions organized into five categories of analysis was used. Categories include family–work relationship, working life, and health and well-being, and the questionnaire was applied to 110 professionals from Colombia and Venezuela. It was found that the compulsory confinement hastened the insertion of journalists in the use of information and communication technologies, applications, and software for content production. Although they were already working in digital media, they had to develop new skills in this field. For 47% of them, their working hours were extended for more than 3 hours a day, which for 79% represents family tensions, given that 38% have underage children or older adults under their care. However, during the confinement, their participation in the formation of public opinion was also expanded through their personal social networks, incorporating corruption issues and citizen complaints. Regarding their routines, it is concluded that the pandemic transformed access to information sources, newsrooms, and, therefore, the dynamics of news production, so we are faced with a new way of doing journalism that puts reporting and ethics into tension with information and communication technologies. | [
"Arts and Humanities (miscellaneous)",
"Communication",
"Cultural Studies"
] | |
Porous boron nitride with a high surface area: hydrogen storage and water treatment | Nanotechnology | [
"Electrical and Electronic Engineering",
"Mechanical Engineering",
"Mechanics of Materials",
"Bioengineering"
] | |
An X-ray absorption study of the dependence of the density of holes on and/or the diamagnetic fraction in the oxycarbonate superconducting system (M=Mo,Cr ) | [
"Materials Chemistry",
"Condensed Matter Physics"
] | ||
News item | Journal of Nuclear Materials | [
"Nuclear Energy and Engineering",
"Nuclear and High Energy Physics"
] | |
Publishing in the 1990s in the UK | [
"Library and Information Sciences",
"Arts and Humanities (miscellaneous)"
] | ||
Treatment of childhood encopresis — a review | Child: Care, Health and Development | [
"Public Health, Environmental and Occupational Health",
"Developmental and Educational Psychology",
"Pediatrics, Perinatology and Child Health"
] | |
Regional MRI Perfusion Measures Predict Motor/Executive Function in Patients with Clinically Isolated Syndrome | Background. Patients with clinically isolated syndrome (CIS) demonstrate brain hemodynamic changes and also suffer from difficulties in processing speed, memory, and executive functions.Objective. To explore whether brain hemodynamic disturbances in CIS patients correlate with executive functions.Methods. Thirty CIS patients and forty-three healthy subjects, matched for age, gender, education level, and FSIQ, were administered tests of visuomotor learning and set shifting ability. Cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) values were estimated in normal-appearing white matter (NAWM) and normal-appearing deep gray Matter (NADGM) structures, using a perfusion MRI technique.Results. CIS patients showed significantly elevated reaction time (RT) on both tasks, while their CBV and MTT values were globally increased, probably due to inflammatory vasodilation. Significantly, positive correlation coefficients were found between error rates on the inhibition condition of the visuomotor learning task and CBV values in occipital, periventricular NAWM and both thalami. On the set shifting condition of the respective task significant, positive associations were found between error rates and CBV values in the semioval center and periventricular NAWM bilaterally.Conclusion. Impaired executive function in CIS patients correlated positively with elevated regional CBV values thought to reflect inflammatory processes. | [
"Neurology (clinical)",
"Neurology",
"Neuropsychology and Physiological Psychology"
] | |
Village of Arlington Heights v. Metropolitan Housing Development Corporation | [
"Law",
"Management, Monitoring, Policy and Law",
"Geography, Planning and Development"
] | ||
Three Spiritual Stages: Purification, Illumination and Deification (κάθαρσις, φωτησμός / ἔλλαμψις, θέωσις) in the Byzantine Tradition | В XIV в. свт. Григорий Палама и его сторонники и продолжатели на основании предшествующей богословской и исихастской традиции Церкви акцентировали особое внимание на учении о видении нетварного Фаворского света и достижении - в состоянии предельной чистоты - состояний озарения и обожения. Известный греческий богослов православного мира прот. Иоанн Романидис в труде «Святоотеческое богословие» считал, что учение об очищении, озарении и обожении передаёт самую суть православия, которое во всех аспектах своего существования сводится именно к эти трём понятиям. В настоящей статье делается попытка дать исторический обзор каждого из трёх терминов, чтобы не только дать оценку взглядам о. Иоанна, но и рельефнее представить место паламитского богословия в более широкой святоотеческой традиции с внутренним идеалом святости как абсолютным императивом. In the XIV century. St. Gregory Palamas and his supporters and successors, on the basis of the previous theological and hesychast tradition of the Church, focused special attention on the doctrine of seeing the uncreated Light of Tabor and achieving-in a state of ultimate purity- the states of illumination and dei cation. The well-known Greek theologian of the Orthodox world, Fr. John Romanidis, in his work Patristic Theology, believed that the doctrine of puri cation, illumination and dei cation conveys the very essence of Orthodoxy, which in all aspects of its existence comes down to these three concepts. This article attempts to give a historical overview of each of the three terms, in order not only to assess the views of Fr. John, but also more clearly present the place of Palamite theology in the broader patristic tradition with the internal ideal of holiness as an absolute imperative. | [
"Polymers and Plastics"
] | |
Susceptibility of the H2-receptor antagonists cimetidine, famotidine and nizatidine, to metabolism by the gastrointestinal microflora | International Journal of Pharmaceutics | [
"Pharmaceutical Science"
] | |
Editorial board | [
"Water Science and Technology",
"Geography, Planning and Development"
] | ||
ODP203 Health Questionnaires are a Positive Behavioral Modifier In Patients with Impaired Blood Sugar In the African American Population. | Abstract Type 2 diabetes and its complications have a higher incidence in African Americans as compared to other racial groups (1). As per the American Diabetes Association, the prevalence of diabetes in non-Hispanic African American patients is 11.7% compared to 7.5% in non-Hispanic white patients. However, few studies have explored what can be done to spark a positive behavioral change leading to lower blood sugar. The purpose of this study is to evaluate if a patient filling out a health questionnaire has any impact on his or her habits by enhancing self-management and awareness to reduce HbA1c. Methods In an outpatient urban clinic, a prospective randomized study was conducted with African American patients with prediabetes with HbA1c 5.6 to 6.7. Patients were randomly assigned to either a survey group or a control group who did not take a survey. The survey included demographic information, weight, diabetes mellitus complication awareness, exercise frequency 3-5 days/week, eating habits, and self-perception. The patients in the survey group filled a follow-up survey 3-6 months later. Results The survey group had 50 respondents and 46 respondents who took the post-survey compared to the control group for which there were 50 respondents with 47 respondents in the control follow-up. In the survey group, 54% were males with an average age of 57 years. In the survey group, on followup HbA1c decreased (6.1 vs 5.7 p<0. 021), BMI decreased (32 vs 29.1 p<0.562), exercise frequency 3-5 days/week increased (10% to 35% p=0. 041), awareness of diabetic complication improved (15 to 74% p=0. 029), willingness to see a dietician increased (28% to 60% p=0. 038), and probability of reading nutrition labels increased (16% to 38% p=0. 058). In the control group, 58% were males with an average age of 56 years. In the control group, on followup HbA1c increased (6.1 vs 6.2), BMI increased (32 vs 33), exercise frequency 3-5 days/week increased (13% to 19% p=0.820), awareness of diabetic complication improved (12%to 16% p=0.673), willingness to see a dietician increased (29% to 38% p=0.340), and probability of reading nutrition labels increased (14% to 19% p=0.646). Conclusion Health questionnaires served as a positive behavioral modifier and helped patients identify and correct their harmful lifestyle habits. Patients in the survey group showed larger amounts of positive change compared to patients in the control group. Reference: (1) Marshall MC Diabetes in African Americans. Postgraduate Medical Journal2005;81: 734-740. Presentation: No date and time listed | Journal of the Endocrine Society | [
"Endocrinology, Diabetes and Metabolism"
] |
HIV Type 1 Subtypes in Guangxi Province, China, 1996 | [
"Infectious Diseases",
"Virology",
"Immunology"
] | ||
Observations of the Variable Star S (10) Sagitt | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Recent Books on Asia | [
"Sociology and Political Science",
"Geography, Planning and Development"
] | ||
STEREOELECTRONIC EFFECTS IN THE HYDROLYSIS OF PHOSPHONIUM IONS FROM ACYCLIC AND BICYCLIC PHOSPHOROTHIONATES | Phosphorus, Sulfur, and Silicon and the Related Elements | [
"Inorganic Chemistry",
"Organic Chemistry",
"Biochemistry"
] | |
History of sociology and the quest for intellectual autonomy in the Global South: The cases of Alberto Guerreiro Ramos and Syed Hussein Alatas | History of sociology is one of the main fields within the broader area of social science research. Despite its growing methodological sophistication, the field still lacks a truly global approach, one that takes into account alternative sociological traditions, particularly those from the so-called Global South. This article seeks to address these shortcomings by proposing a case study comparison between two sociologists from the Global South who developed similar sociological discourses between the 1950s and 1970s and pursued intellectual autonomy. These were the Brazilian Alberto Guerreiro Ramos (1915–1982) and the Malaysian Syed Hussein Alatas (1927–2008). The article analyzes the main works of Ramos and Alatas and compares their trajectories as well. It is argued that the sociological discourses in the Global South are best explained through a transnational analysis that pays close attention to the conditions of intellectual labor and the quest for intellectual autonomy in this area. It is also argued that the field of history of sociology should take into account these alternative discourses in order to avoid Eurocentrism. | [
"Sociology and Political Science"
] | |
Post-Cesarean Adhesion Syndrome | Journal of Gynecologic Surgery | [
"Obstetrics and Gynecology",
"Surgery"
] | |
In the midst of plenty: Experiences of food insecurity amongst women living with HIV in Vancouver, Canada | Health & Social Care in the Community | [
"Public Health, Environmental and Occupational Health",
"Health Policy",
"Sociology and Political Science",
"Social Sciences (miscellaneous)"
] | |
Coexistence Performance of High-Altitude Platform and Terrestrial Systems Using Gigabit Communication Links to Serve Specialist Users | [
"Computer Networks and Communications",
"Computer Science Applications",
"Signal Processing"
] | ||
Integrating environmental covariates and crop modeling into the genomic selection framework to predict genotype by environment interactions | [
"Genetics",
"Agronomy and Crop Science",
"Biotechnology"
] | ||
Confirmatory factor analysis of the Child Feeding Questionnaire: a measure of parental attitudes, beliefs and practices about child feeding and obesity proneness | [
"Nutrition and Dietetics"
] | ||
Response of soybean (Glycine max (L.) Merr.) to bacterial soil inoculants and foliar fertilization | [
"Soil Science"
] | ||
Knock Down of Erythrulose Kinase (eyk1) Leads to the Enhancement of Erythritol Production in Yarrowia lipolytica Mutant Strain YE4-2 | American Journal of Biochemistry and Biotechnology | [
"Biochemistry",
"Biotechnology"
] | |
Observation of extreme phase transition temperatures of water confined inside isolated carbon nanotubes | [
"Electrical and Electronic Engineering",
"Condensed Matter Physics",
"Biomedical Engineering",
"Atomic and Molecular Physics, and Optics",
"Bioengineering"
] | ||
Automating the Assessment of Networking and Security in Higher Education | In the subject of computer networking students must understand the concepts and be confident in configuring and securing a range of network devices and systems. Challenges are faced in assessing practical networking and security exercises in a laboratory environment utilising multivariate devices and operating systems that involve real or simulated systems operating in real or virtualized environments. The working environment for a practical exercise must be pre-configured and once an exercise has been completed the results extracted to enable formative or summative assessment of the outcomes. Using manual methods this process can be time consuming and it would therefore be beneficial to implement some form of automation. To facilitate this a new application has been developed that automates the configuration management and assessment processes within a computer networking laboratory. The new application has been successfully used to assess the extent to which students have been able to configure secure networks using case-study based exercises. The development challenges of the application and rationale for the implementation of the prototype application are discussed. A test methodology is presented in which the application is used to assess the outcomes of a computer networking exercise, comparing the results obtained from the application with those of a proprietary simulator. This demonstrates that the prototype application is able to successfully and accurately automate the assessment of the practice of networking and security in the context of defined parameters. Further work is suggested to improve the assessment mechanism employed by the application, seek enhancements and to conduct additional tests. | [
"Electrical and Electronic Engineering"
] |
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