Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
System modeling and identification of a balance type checkweigher compensated by voice coil actuator | The aim of this article is to investigate the characteristics of checkweigher which consists of two parts: electrical part (voice coil actuator) and mechanical part (lever-pivot mechanism). Its integrated weighing system simplified m, c, and k model, and system identification is performed through comparison of experimental results and simulated results by Simulink. m and k are attributed to the mechanical part and c is mainly due to the electromagnetic damping of voice coil actuator. Even with a determined voice coil actuator, the damping effect can be adjusted by the relocation of voice coil actuator to improve the performance of checkweigher. The validity of the simplified model is verified by comparing simulation and experimental results. | Advances in Mechanical Engineering | [
"Mechanical Engineering"
] |
Chlorine dioxide disinfection technology to avoid bromate formation in desalinated seawater in potable waterworks | [
"Mechanical Engineering",
"Water Science and Technology"
] | ||
The role of photoreception in the swarming behavior of the copepodDioithona oculata | [
"Aquatic Science",
"Physiology",
"Oceanography"
] | ||
Motion Monitoring of MEMS Actuator with Electromagnetic Induction | [
"Applied Mathematics",
"Electrical and Electronic Engineering",
"Computer Networks and Communications",
"Signal Processing"
] | ||
Preliminary analysis to BIIR recovery using the microwave process | [
"Organic Chemistry",
"Polymers and Plastics",
"Materials Chemistry"
] | ||
Malignant mesothelioma: Diagnostic and management strategies for 1992 | [
"Cancer Research",
"Pulmonary and Respiratory Medicine",
"Oncology"
] | ||
Olaf Helmer. Languages with expressions of infinite length. Erkenntnis, vol. 7 no. 3 (1938), pp. 138–141. | [
"Logic",
"Philosophy"
] | ||
Data‐adaptive polarization filters for multichannel geophysical data | The design of data‐adaptive filters requires that the noise be defined, statistically or otherwise, by parameters which allow some means of separating the noise from the signal. We consider here multichannel data in which one knows only that the noise is less polarized than the signal in a unitary space. This description of the noise is not sufficient for designing filters which are optimum in any sense; consequently, the filters may require a number of changes in the parameters before a satisfactory design can be found. Once this design has been achieved, the filters can be used to enhance waveforms of arbitrary shape, requiring little prior knowledge of the spectral content or temporal features of the signal. In contrast to many other data‐adaptive filters which give a scalar time‐series output, the filters we describe here with vector time series input have an equal number of input and output channels. A number of examples of filtered magnetic and seismic data are given in order to emphasize the wide range of uses for the filters. Some suggestions for application of the filters to multichannel seismic data are given. | GEOPHYSICS | [
"Geochemistry and Petrology",
"Geophysics"
] |
Requests for Meeting Information | [
"Cardiology and Cardiovascular Medicine",
"Pulmonary and Respiratory Medicine",
"Surgery"
] | ||
Paramètres d'écoulement diphasique dans un ébullition a la cuve en acier pendant un refroidissement d'un APRP de APR1400 | [
"Water Science and Technology"
] | ||
A Mercedarian Antiphonary | Revue de musicologie | [
"Music"
] | |
THE MOON | [
"Literature and Literary Theory"
] | ||
Multiscale Asymptotic Method for Steklov Eigenvalue Equations in Composite Media | [
"Numerical Analysis",
"Applied Mathematics",
"Computational Mathematics"
] | ||
Structural Transformations and Fracture Energy of the Molybdenum Single Crystals Under Fatigue | [
"Mechanics of Materials",
"Materials Science (miscellaneous)"
] | ||
Bone Marrow Niche-Derived Extracellular Matrix-Degrading Enzymes Influence the Progression of B-Cell Acute Lymphoblastic Leukemia | Abstract Interactions with the bone marrow microenvironment (BMM) influence the pathophysiology of hematological malignancies. Reciprocally, hematological malignancies remodel the BMM in order to render it more hospitable for malignant progression. Hypothesizing that different leukemias differentially remodel stroma cells in the BMM, we tested differences in the expression of various genes in sorted osteoblastic cells from mice with B-cell acute lymphoblastic (B-ALL), acute myeloid (AML) or chronic myeloid leukemia (CML) or control mice by microarray. This revealed a high expression of various proteases, especially matrix metalloproteinase-9 (MMP-9), in osteoblastic cells isolated from mice with B-ALL. MMP-9 had previously been shown to be produced by leukemia cells. To investigate the physiological relevance of BMM-derived MMP-9 for the progression of B-ALL, we employed the well-established retroviral transduction/transplantation model of BCR-ABL1-dependent B-ALL in MMP-9-deficient or wildtype mice. Deficiency of MMP-9 in the BMM prolonged the survival of mice with B-ALL compared to wildtype mice. Secondary transplantation of bone marrow from wildtype versus MMP-9 knockout (KO) mice with B-ALL led to a significant prolongation of survival of recipients of B-ALL bone marrow from MMP-9 KO mice, suggesting that leukemia-initiating cells are reduced in a MMP-9 KO BMM. In addition, we observed reduced invasion of B-ALL cells into different organs such as spleen, meninges, lungs and liver, which likely underlies the observed prolongation of survival, as well as the reduced degradation of extracellular matrix (ECM) proteins such as laminin and fibronectin in the BMM of MMP-9 deficient mice. Mechanistically, using various in vivo and in vitro assays, as well as mice deficient for the receptor for tumor necrosis factor-α (TNF-α) we have demonstrated that B-ALL cells induce MMP-9-expression in niche cells, such as mesenchymal stem cells (MSC), via a release of high amounts of TNF-α, both in the murine and the human setting. TNF-α-dependent induction of MMP-9 in MSC was mediated via TNF-receptor-1, followed by activation of the downstream target nuclear factor kappa B (NF-kB). Consistently, transplantation of B-ALL-initiating cells, in which TNF-α had been knocked down, led to a significant prolongation of survival in B-ALL mice. Testing whether treatment of mice with B-ALL with an inhibitor of MMP-9 may prolong survival compared to vehicle-treated mice, we indeed found decreased degradation of ECM proteins in the BMM, a decreased leukemia burden in peripheral blood and a significant prolongation of survival. In addition, we observed reduced minimal residual disease in the bone marrow of mice with B-ALL when the mice had been treated with cytarabine and the MMP-9 inhibitor compared to mice treated with cytarabine alone. Experiments on testing the effect of MMP-9 inhibitor treatment on human B-ALL cells in a xenotransplantation model are currently ongoing. In summary, we have demonstrated the role of BMM-derived MMP-9 for B-ALL progression. B-ALL cells self-reinforce the BMM by inducing the production of MMP-9 via the release of TNF-α. Increased production of MMP-9 from the BMM promotes B-ALL progression via increased invasion of leukemic cells into different organs. Our data suggest, that inhibition of MMP-9 may be a feasible strategy as an adjunct to existing therapies. Disclosures Krause: Glycotope: Consultancy; Glycomimetics Inc. until 06/2016: Consultancy, Research Funding; Merck KgGA in future: Research Funding; European Patent: Patents & Royalties: European Patent No. 16187926.7-1401 "FIBRONECTIN FOR USE IN THE TREATMENT OF LEUKEMIA" . | Blood | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] |
Pulmonary hypertension and cardiomyopathy: anaesthetic management for Caesarean section | [
"Anesthesiology and Pain Medicine"
] | ||
Quality of life and adherence to treatment in early-treated Brazilian phenylketonuria pediatric patients | Brazilian Journal of Medical and Biological Research | [
"Cell Biology",
"Immunology",
"Physiology",
"Biochemistry",
"Biophysics",
"Ocean Engineering"
] | |
Therapeutic Use of Gonadoliberin (Follicle-Stimulating Hormone/Luteinizing Hormone-Releasing Hormone) in Women | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | ||
Louis Martineau | [
"Library and Information Sciences",
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
Clinical Trial of Therapeutic Blockade of CTLA4 with Ipilimumab in Patients with Relapse of Malignancy Following Allogeneic Hematopoietic Transplantation. | Abstract Relapse/progression of malignancy (RM) is an important cause of treatment failure and death following allogeneic hematopoietic stem cell transplantation (allo-HCT). CTLA-4 is an important negative regulator of effector T-cell activation. CTLA-4 inhibition has demonstrated potent anti-cancer effects in animal models, and in patients with some solid tumors. CTLA-4 blockade following allo-HCT may potentially augment graft-versus-malignancy but GVHD may also possibly be increased. We report the safety and preliminary efficacy of a dose-escalation study of a neutralizing human monoclonal antibody targeting CTLA-4 (ipilimumab) in patients with RM following allo-HCT. Eligibility criteria included allo-HCT ≥90 days previously, > 50% donor T-cell chimerism, no prior grade 3/4 GVHD, no prophylaxis/therapy for GVHD for ≥ 6 weeks. Patients received a single dose of ipilimumab over 90 min. DLI at a dose of 5 × 10e6 CD3 cells/kg was allowed 8 weeks following ipilimumab if no GVHD occurred and RM was present. A total of 29 patients were treated at four centers (23M, 6F; median age 43 (21–65); Hodgkins disease [HD] =14 Myeloma [MM]=6, CML=2, CLL=2, AML=2, NHL=1, Renal Ca =1, Breast Ca=1; 19 related donors, 10 unrelated; 6 myeloablative, 23 RICT).(4 at dose-level 1 [DL1] 0.1 mg/kg, 3 at 0.33 mg/kg [DL2], 4 at 0.66 mg/kg [DL3], 3 at 1.0 mg/kg [DL4] and 15 at 3.0 mg/kg [DL5]). Eight patients had failed prior DLI. Median time between BMT and ipilimumab was 366 d (125–2368). Dose-limiting toxicity was not encountered. No patient developed clinically significant GVHD within 90 days following ipilimumab alone. Three possible immune adverse events were documented: grade 3 polyarthropathy 14 weeks following ipilimumab, and 6 weeks post DLI, which resolved with corticosteroid therapy, (AML, DL1); grade 1 hyperthyroidism with thyroid-stimulating antibody 6 weeks post ipilimumab (CLL, DL3). Grade 2 pneumonitis responsive to corticosteroids (HD, DL5). Ten patients received DLI after ipilimumab. Three patients developed objective evidence of disease response after ipilimumab alone: PR in a patient with mantle cell NHL lasting 3m [DL4]; ongoing CR in a two patients with HD [DL5]. Two of these patients had failed prior DLI. Three additional patients demonstrated possible anti-cancer effects (MR in a HD patient, reduction of PB and BM blasts in AML, DL1; maintenance of molecular remission in a CML patient given ipilimumab alone for 3.5 yrs despite stopping imatinib, DL1). This study shows that doses of ipilimumab (up to 3.0 mg/kg) can safely be administered to patients with RM following allo-HCT without inducing/exacerbating GVHD while inducing regressions of malignancy including durable CR in some patients. | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] | |
La enseñanza de las políticas públicas en América Latina: estado de la situación y desafíos para la ciencia política | El presente artículo tiene como objeto de análisis la enseñanza de las políticas públicas en las licenciaturas de Ciencia Política de 11 países de América Latina. Se abordan los perfiles de los docentes, los enfoques privilegiados, los autores y textos más citados, y el sitial asignado al conocimiento producido dentro y fuera del subcontinente. Tras el análisis de 109 programas de 63 universidades, se constatan distintas matrices de formación superior de los docentes –en unas predominan las titulaciones locales y en otras las del exterior–. Lo anterior se asocia con la influencia relativa que otorgan a la producción académica nacional y extranjera al momento de elaborar las bibliografías de sus cursos. Se comprueba también la insuficiente recepción de textos producidos en otros países de la región, aunque las referencias a la producción latinoamericana han crecido progresivamente. Con diferentes grados según el país, las manifestaciones de asimilación lineal de marcos y enfoques teóricos producidos en y para los países del norte, la autorreferenciación de la producción nacional y la escasa conexión con otras propuestas latinoamericanas aparecen como los principales obstáculos para construir una “ciencia de las políticas” que, al mismo tiempo, se instituya en diálogo con la producción internacional más influyente, y resulte apta para dar cuenta de las particularidades de cada experiencia nacional y de las dinámicas regionales. | [
"Social Sciences (miscellaneous)",
"Sociology and Political Science",
"Anthropology",
"Gender Studies"
] | |
Canonical relationships between vocational interests and personality of adult handicapped persons. | Rehabilitation Psychology | [
"Psychiatry and Mental Health",
"Clinical Psychology",
"Rehabilitation",
"Physical Therapy, Sports Therapy and Rehabilitation"
] | |
Tuberculosis of the caecum | [
"Surgery"
] | ||
Questionnaire Based Assessment of Patients' Acceptability of Leukocytapheresis for the Treatment of Inflammatory Bowel Disease | [
"Nephrology",
"Hematology"
] | ||
Different Effects of Carvedilol, Metoprolol, and Propranolol on Left Ventricular Remodeling After Coronary Stenosis or After Permanent Coronary Occlusion in Rats | Background — Although carvedilol attenuates left ventricular (LV) remodeling in coronary occlusion-reperfusion, it is not known whether it attenuates ischemic LV remodeling because of coronary stenosis (CS) or permanent coronary occlusion (CO). Methods and Results — We administered a vehicle, carvedilol, propranolol (2, 10, and 30 mg/kg per day, each), metoprolol (6, 30, and 90 mg/kg per day), or bunazosin (0.2 and 1 mg/kg per day), orally for 12 weeks to a total of 608 rats with CS or CO. In these groups and the sham (n=40), we assessed LV function by echocardiography, CS severity, myocardial blood flow and coronary flow reserve, serum ascorbyl free radical, and vitamin C. Both CS and CO increased LV end-diastolic and end-systolic diameters and decreased ejection fraction. The 4 agents failed to attenuate LV remodeling caused by CO. In contrast, the 3 β-blockers attenuated ( P Conclusions — The effects of β blockade on ischemic cardiac dysfunction seem to depend on the different properties of the β-blockers and the doses used. Among the β-blockers tested, carvedilol provided potent cardioprotection for compromised ischemic but viable myocardium rather than for infarcted myocardium. | [
"Physiology (medical)",
"Cardiology and Cardiovascular Medicine"
] | |
Response of the interrenal gland of rainbow trout (Salmo gairdneri) to stress | General and Comparative Endocrinology | [
"Endocrinology",
"Animal Science and Zoology"
] | |
Constructions relatives : développer un point de vue fonctionnaliste | [
"Linguistics and Language",
"Arts and Humanities (miscellaneous)"
] | ||
An efficient route to biaryls from aryl halides catalysed by subnanometrical 2,2′-bipyridine liganded Ni–Al clusters | Tetrahedron | [
"Organic Chemistry",
"Drug Discovery",
"Biochemistry"
] | |
THE EFFECT OF RADIATION DOSE FRACTIONATION ON CHROMOSOME ABERRATION FREQUENCIES IN TRADESCANTIA MICROSPORES. II. STUDIES WITH FAST NEUTRONS | [
"Genetics"
] | ||
A normal mode inner product to account for acoustic propagation over horizontally variable bathymetry | [
"Acoustics and Ultrasonics",
"Arts and Humanities (miscellaneous)"
] | ||
The action of alcohol upon conduction in the auricle of the tortoise | [
"Physiology"
] | ||
Impact of the Municipal Solid Waste Typology on Leachate Flow under Semi-Arid Climate – A Case Study | [
"Ecology, Evolution, Behavior and Systematics"
] | ||
Become more optimistic by imagining a best possible self: Effects of a two week intervention | [
"Psychiatry and Mental Health",
"Arts and Humanities (miscellaneous)",
"Clinical Psychology",
"Experimental and Cognitive Psychology"
] | ||
J.M. Murray, with the Collaboration of W. Prevenier and M. Oosterbosch, Notarial Instruments in Flanders between 1280 and 1452 | AbstractNo Abstract | [
"Law",
"History"
] | |
Clinical efficacy and tolerability of olmesartan | [
"Pharmacology (medical)",
"Pharmacology"
] | ||
Effectiveness of nifedipine and deflazacort in the management of distal ureter stones | [
"Urology"
] | ||
Some Remarks on the Numerical Modelling of Localized Failure | An efficient numerical framework suitable for three-dimensional analyses of brittle material failure is presented. The proposed model is based on an (embedded) Strong Discontinuity Approach (SDA). Hence, the deformation mapping is elementwise additively decomposed into a conforming, continuous part and an enhanced part associated with the kinematics induced by material failure. To overcome locking effects and to provide a continuous crack path approximation, the approach is extended and combined with advantages known from classical interface elements. More precisely, several discontinuities each of them being parallel to a facet of the respective finite element are considered. By doing so, crack path continuity is automatically fulfilled and no tracking algorithm is necessary. However, though this idea is similar to that of interface elements, the novel SDA is strictly local (finite element level) and thus, it does not require any modification of the global data structure, e.g., no duplication of nodes. An additional positive feature of the advocated finite element formulation is that it leads to a symmetric tangent matrix. It is shown that several simultaneously active discontinuities in each finite element are required to capture highly localized material failure. The performance and predictive ability of the model are demonstrated by means of two benchmark examples. | Key Engineering Materials | [
"Mechanical Engineering",
"Mechanics of Materials"
] |
Abscess formation after hyaluronic acid injection laryngoplasty in an infant | International Journal of Pediatric Otorhinolaryngology | [
"Otorhinolaryngology",
"Pediatrics, Perinatology and Child Health"
] | |
SAT0102 NONINFLAMMATORY PAIN IS A FREQUENT PHENOMENON IN RHEUMATOID ARTHRITIS AND RESPONDS WELL TO TREATMENT WITH SARILUMAB | Background:Inflammation is clearly a key driver of pain in rheumatoid arthritis (RA). However, in some patients the level of pain exceeds what would be expected based on the amount of synovitis observed, which may indicate the presence of noninflammatory pain (NIP). Interleukin-6 (IL-6) has been shown in animal models to increase sensitization to pain and may play a role in NIP.Objectives:To assess the effect of sarilumab, a human IL-6 receptor inhibitor approved for the treatment of adults with moderate to severely active RA, on NIP and disease activity, stratified by baseline (BL) NIP status.Methods:The analysis included data from three Phase 3 studies of sarilumab: MOBILITY (NCT01061736), MONARCH (NCT02332590), and TARGET (NCT01709578). Patients received double-blind placebo or sarilumab 150 mg or 200 mg subcutaneously (SC) every 2 weeks (q2w), plus weekly csDMARD (MOBILITY and TARGET), or adalimumab 40 mg or sarilumab 200 mg SC q2w as monotherapy (MONARCH).NIP was defined using an established formula: tender 28-joint count (TJC) – swollen 28-joint count (SJC) ≥7.1,2Patients were assessed for NIP at study BL and for change in NIP status at Weeks 12 and 24. The proportion of patients achieving ACR20/50/70, Clinical Disease Activity Index (CDAI) ≤10, and DAS28-CRP Results:Of 2112 patients in the analysis, 490 (23%) met the criteria for NIP at study BL: MOBILITY, n = 294/1197 (25%); MONARCH, n = 90/369 (24%); TARGET, n = 106/546 (19%). BL demographics were similar for patients with or without BL NIP: mean age (SD) was 52.6 (10.7) versus 51.2 (12.3) years, and 85% versus 81% were female. Patients with BL NIP had higher CDAI, DAS28-CRP, pain Visual Analog Scale (VAS), and TJC at BL versus patients without NIP (Table). Of patients with NIP at BL, those who received sarilumab were more likely to have no NIP at Weeks 12 and 24 versus patients who received placebo or adalimumab (Figure 1). The percentage of patients achieving improvements in disease activity at Week 24 was greater for sarilumab versus adalimumab among both patients with and without BL NIP, and these differences were larger among patients with BL NIP for all assessments except ACR50 (Figure 2).Table.Baseline characteristicsPatients with TJC – SCJ ≥7Mean (SD)Yes (n = 490)No (n = 1622)Duration of RA, years9.1 (8.6)9.7 (8.4)TJC, 0–2821.7 (4.7)14.3 (6.2)SJC, 0–2810.7 (4.3)13.1 (6.0)CRP, mg/L22.7 (27.0)22.9 (24.0)HAQ-DI, 0–31.8 (0.6)1.7 (0.6)DAS28-CRP6.4 (0.7)5.9 (0.9)CDAI46.0 (9.4)40.4 (13.0)Pain VAS72.3 (18.2)67.0 (20.7)Conclusion:NIP was prevalent at BL in the patient populations assessed. Among patients with BL NIP, a lower proportion continued to have NIP at Weeks 12 and 24 when treated with sarilumab versus placebo or adalimumab. Patients with and without BL NIP had greater improvements in pain when treated with sarilumab versus adalimumab. The difference in clinical improvement was greater among patients with BL NIP versus without BL NIP for most measures. These trends support the emerging concept that mechanisms other than direct inflammation may contribute to pain in RA, potentially mediated via IL-6 signaling.References:[1]Durán J et al.Rheumatology. 2015;54:2166–70[2]Pollard LC et al.Rheumatology. 2010;49:924–8Acknowledgments:Study funding and medical writing support (Joseph Hodgson, PhD, Adelphi Communications Ltd, Macclesfield, UK) provided by Sanofi Genzyme (Cambridge, MA, USA) and Regeneron Pharmaceuticals, Inc. (Tarrytown, NJ, USA) in accordance with GPP3 guidelines.Disclosure of Interests:Ernest Choy Grant/research support from: Amgen, Bio-Cancer, Chugai Pharma, Ferring Pharmaceuticals, Novimmune, Pfizer, Roche, UCB, Consultant of: AbbVie, Amgen, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Chelsea Therapeutics, Chugai Pharma, Daiichi Sankyo, Eli Lilly, Ferring Pharmaceuticals, GlaxoSmithKline, Hospita, Ionis, Janssen, Jazz Pharmaceuticals, MedImmune, Merck Sharp & Dohme, Merrimack Pharmaceutical, Napp, Novartis, Novimmune, ObsEva, Pfizer, R-Pharm, Regeneron Pharmaceuticals, Inc., Roche, SynAct Pharma, Sanofi Genzyme, Tonix, UCB, Speakers bureau: Amgen, Boehringer Ingelheim, Bristol-Myers Squibb, Chugai Pharma, Eli Lilly, Hospira, Merck Sharp & Dohme, Novartis, Pfizer, Regeneron Pharmaceuticals, Inc., Roche, Sanofi-Aventis, UCB, Vivian Bykerk: None declared, Yvonne Lee Shareholder of: Cigna-Express Scripts, Grant/research support from: Pfizer, Consultant of: Highland Instruments, Inc., Gregory St John Shareholder of: Regeneron Pharmaceuticals, Inc., Employee of: Regeneron Pharmaceuticals, Inc., Hubert van Hoogstraten Shareholder of: Sanofi, Employee of: Sanofi, Kerri Ford Shareholder of: Sanofi Genzyme, Employee of: Sanofi Genzyme, Amy Praestgaard Employee of: Sanofi Genzyme, Anthony Sebba Consultant of: Genentech, Gilead, Lilly, Regeneron Pharmaceuticals Inc., Sanofi, Speakers bureau: Lilly, Roche, Sanofi | [
"Immunology",
"Immunology and Allergy",
"Rheumatology"
] | |
Practical and Pedagogical Aspects of Learning Through Participation: the LTP Assessment Design Framework | Assessment of student learning in experience-based education is recognised as being a complex but important task. Practitioners are faced with a myriad of practical and pedagogical issues that influence what and how they assess, and can severely impact the effectiveness of assessment strategies. This paper presents a synthesised overview of the literature about assessment of student learning that is usually discussed in dispersed arenas and under different headings, such as work-integrated learning, cooperative education, practicum, project-based learning and service-learning etc. The term Learning through Participation (LTP) is introduced to cover all of these areas, but especially those where students undertake experiences and placements that incorporate community engagement and which are based within the curriculum. The literature in this area highlights a number of issues that add layers to the complexity of assessment of LTP. The synthesis presented herein discusses questions of validity, objective verification of learning, the roles and expectations of various stakeholders in the process of assessment, and the role and purpose of reflection in learning and assessment. To assist practitioners a LTP Assessment Design Framework has been created, which guides academics though a consideration and analysis of the practical and pedagogical context of LTP and some of the most important issues. The framework consists of two parts. The first part involves the development of a Placement Profile, to better understand the operational conditions for which the assessment package must be designed, and the second part is a set of Guiding Questions about assessment and feedback. | [
"Education"
] | |
Structural and mechanistic basis of porphyrin metallation by ferrochelatase | [
"Molecular Biology",
"Structural Biology"
] | ||
On the symmetry of minimizers in constrained quasi-linear problems | [
"Applied Mathematics",
"Analysis"
] | ||
The intrinsic constraint approach to cue combination: An empirical and theoretical evaluation | [
"Sensory Systems",
"Ophthalmology"
] | ||
Vortex core formation in a Francis turbine during transient operation from best efficiency point to high load | [
"Condensed Matter Physics",
"Fluid Flow and Transfer Processes",
"Mechanics of Materials",
"Computational Mechanics",
"Mechanical Engineering"
] | ||
Back Matter | [
"Education"
] | ||
On the threshold | [
"Orthopedics and Sports Medicine"
] | ||
Arteriovenograma de cemento óseo en artroplastia de cadera | [
"Orthopedics and Sports Medicine",
"Surgery"
] | ||
Propoxyphene on Demand | Archives of General Psychiatry | [
"Psychiatry and Mental Health",
"Arts and Humanities (miscellaneous)"
] | |
Robotic-assisted laparoscopic ureteral re-implant (RALUR): Can post-operative urinary retention be predicted? | [
"Urology",
"Pediatrics, Perinatology and Child Health"
] | ||
Travolti dall’ascesi? Famiglie aristocratiche di Gallia passate dal secolo a Dio (fine IV - prime decadi V secolo) | [
"Earth-Surface Processes"
] | ||
Fever after anti-programmed cell death-1 treatment to predict the response in advanced hepatocellular carcinoma. | 90 Background: Anti-programmed cell death (PD)-1, an immune checkpoint inhibitor, has been recently approved for the treatment of patients with HCC following prior sorafenib. However, a reliable predictor of treatment response has not been established. Patients who experienced immune-related adverse events (irAEs) of any grade yielded a significantly higher response rate than did those did not experience irAEs. Methods: Three cases of advanced HCC with or without previous sorafenib treatment, underwent anti-PD-1 treatment (pembrolizumab, 2 mg/kg, at 3-week interval) with or without combination of sorafenib (400mg daily). Results: Case 1 Fever (38.3°C) developed 2 days after anti-PD-1 treatment. The fever persisted for 2 months and gradually subsided (Figure 2B). Follow-up computed tomography (CT) revealed persistent tumor shrinkage and complete response at the latest time of examination (Figure 1B); the treatment is ongoing. Case 2 Spiking fever developed after each time of anti-PD-1 treatment. Follow-up CT revealed a remarkable decrease in the tumor size (3 cm), resulting in a partial response (Figure 1D); the treatment is ongoing. Case 3 Twelve days after the treatment, the patient complained of fever and general weakness. Laboratory data revealed tumor lysis syndrome and disseminated intravascular coagulopathy (DIC). HBV, hepatitis B virus; HCV, hepatitis C virus; BCLC, Barcelona Clinic Liver Cancer; AFP, alpha-fetoprotein; TACE, transarterial chemoembolization; CR, complete response; PR, partial response. Conclusions: Fever may be an early predictor of response to anti-PD-1 treatment. The degree of fever seemed to be correlated with tumor burden. High fever may suggest cytokine storm and possible tumor lysis syndrome. Early detection is necessary for the immediate prescription of steroids and management of tumor lysis.[Table: see text] | Journal of Clinical Oncology | [
"Cancer Research",
"Oncology"
] |
Nivolumab and ipilimumab in combination with radiotherapy in patients with locally advanced head and neck cancer | [
"Oncology",
"Hematology"
] | ||
The Shape of Germanium Clusters To Come | [
"Catalysis"
] | ||
Periodic microstructuring of iron cylinder surface in nitric acid in a magnetic field | Applied Surface Science | [
"Surfaces, Coatings and Films",
"Condensed Matter Physics",
"Surfaces and Interfaces"
] | |
OC-0318: Hematological toxicity during bowel sparing IMRT: Exploratory analysis from PARCER Phase III trial | [
"Radiology, Nuclear Medicine and Imaging",
"Oncology",
"Hematology"
] | ||
Bondi accretion in the finite luminous region of elliptical galaxies | Abstract The classical Bondi model is adopted to study accretion onto the finite luminous region around the central massive black hole (MBH) in an elliptical galaxy. Unlike Bondi (1952), we define the boundary conditions at a certain finite radius (rf) instead of at the infinity and examine the variation of solutions for a simple case. In the following, we consider the special case of a MBH at the center of a Hernquist galaxy and involve the gravity and luminosity of its own galaxy. Our results in the first part show that kinitic energy at the final radius is ignorable even for not so far away from the center. Moreover, the mass accretion rate will be approximately equal to its Bondi value if the final radius (rf) becomes about 2-3 orders of magnitude larger than semi-Bondi radius, i.e. $GM/c_{sf | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | |
Editorial Board | [
"Sociology and Political Science",
"History",
"Cultural Studies"
] | ||
Lois de réciprocité supérieures et points rationnels | Soit K = C ( ( x , y ) ) K=\mathbb {C | [
"Applied Mathematics"
] | |
Regulation of Gene Expression of Pancreatic Secretory Trypsin Inhibitor-61 and -56 by Bile and Pancreatic Juice in Rats | [
"Endocrinology",
"Hepatology",
"Endocrinology, Diabetes and Metabolism",
"Internal Medicine"
] | ||
PRINCIPAIS CONCEITOS DA ESTATÍSTICA DESCRITIVA: UMA ABORDAGEM DIFERENCIADA / MAIN CONCEPTS OF DESCRIPTIVE STATISTICS: A DIFFERENTIATED APPROACH | [
"Marketing",
"Organizational Behavior and Human Resource Management",
"Strategy and Management",
"Drug Discovery",
"Pharmaceutical Science",
"Pharmacology"
] | ||
Laparoscopic Interstitial Contact Laser Ablation of Renal Lesions: An Experimental Model | [
"Urology"
] | ||
Aschenanalyse der Runkelrübe (Beta cicla altissima) | [
"Organic Chemistry",
"Physical and Theoretical Chemistry"
] | ||
Mammalian Sprouty-1 and -2 Are Membrane-Anchored Phosphoprotein Inhibitors of Growth Factor Signaling in Endothelial Cells | Growth factor–induced signaling by receptor tyrosine kinases (RTKs) plays a central role in embryonic development and in pathogenesis and, hence, is tightly controlled by several regulatory proteins. Recently, Sprouty, an inhibitor of Drosophila development-associated RTK signaling, has been discovered. Subsequently, four mammalian Sprouty homologues (Spry-1–4) have been identified. Here, we report the functional characterization of two of them, Spry-1 and -2, in endothelial cells. Overexpressed Spry-1 and -2 inhibit fibroblast growth factor– and vascular endothelial growth factor–induced proliferation and differentiation by repressing pathways leading to p42/44 mitogen-activating protein (MAP) kinase activation. In contrast, although epidermal growth factor–induced proliferation of endothelial cells was also inhibited by Spry-1 and -2, activation of p42/44 MAP kinase was not affected. Biochemical and immunofluorescence analysis of endogenous and overexpressed Spry-1 and -2 reveal that both Spry-1 and -2 are anchored to membranes by palmitoylation and associate with caveolin-1 in perinuclear and vesicular structures. They are phosphorylated on serine residues and, upon growth factor stimulation, a subset is recruited to the leading edge of the plasma membrane. The data indicate that mammalian Spry-1 and -2 are membrane-anchored proteins that negatively regulate angiogenesis-associated RTK signaling, possibly in a RTK-specific fashion. | [
"Cell Biology"
] | |
Reappraisal of the ill-defined Liassic pteridosperm Dichopteris using an ultrastructural approach | [
"Plant Science",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Optimization and modeling of spot welding parameters with simultaneous multiple response consideration using multi-objective Taguchi method and RSM | [
"Mechanical Engineering",
"Mechanics of Materials"
] | ||
Meeting the Needs of Children from Disadvantaged Households: The Derner-Hempstead Child Clinic | Journal of Infant, Child, and Adolescent Psychotherapy | [
"Psychiatry and Mental Health",
"Clinical Psychology"
] | |
Flux‐profile relation with roughness sublayer correction | [
"Atmospheric Science"
] | ||
A study on the catalytic behaviour of Cd(II) and Sm(III) coordination complexes towards the four-component synthesis of quinoline-3-carboxylates | [
"Materials Chemistry",
"Inorganic Chemistry",
"Physical and Theoretical Chemistry"
] | ||
Starbursts in isolated galaxies | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Cellular Activation by Plasmid DNA in Various Macrophages in Primary Culture | [
"Pharmaceutical Science"
] | ||
Dairy Products Added in Media Affect the Development of Drosophila melanogaster (Diptera: Drosophilidae) | [
"Insect Science"
] | ||
Les oiseaux de l’archipel des Loyauté (Nouvelle-Calédonie) : inventaire et éléments d’écologie et de biogéographie | The birds of the Loyalty Islands (New Caledonia) : census, ecological and biogeographical issues. — The avifauna of the Loyalty Islands comprises 62 species, including 14 breeding or erratic seabirds, 5 migratory birds, 7 herons, ducks and rails, 4 birds of prey, 28 indigenous land breeders (belonging to 33 subspecies) and 2 species introduced from the Grande Terre (main island of New Caledonia). Six species are endemic : 3 on the Grande Terre and in the Loyalty Islands (New Caledonian Friarbird Philemon diemenensis, Green-backed White-eye Zosterops xanthochrous, Striated Starling Aplonis striatus) and 3 only found in the Loyalty Islands (Ouvea Parakeet Eunymphicus uvaeensis, Large Lifou White-eye Zosterops inornatus and Small Lifou White-eye Z. minutus). Eunymphicus is an endemic genus of New Caledonia. Eight subspecies are endemic to both the Grande Terre and the Loyalty Islands and 11 are exclusive of the Loyalty Islands. Of the 24 taxa whose geographical origin could be identified, 58% are identical or similar to those on the Grande Terre, 105 km away, and 42% have affinities with birds in Vanuatu, twice as far away (225 km). The paths of cyclones could explain the specific influence of Vanuatu. The correlation between the islands’land area and the number of species that have successfully settled is very close (r = 0.97) and confirms this biogeographical standard. The land breeding species frequencies vary, with rare localized species limited to some islands (Bluefaced Parrotfinch Erythrura trichroa, Ouvea Parakeet), or possibly extinct (Island Thrush Turdus poliocephalus) and others whose frequency varies widely from place to place (Fan-tailed Cuckoo Cacomantis flabelliformis, Gerygone Gerygone flavolateralis, Silvereye Zosterops lateralis), while others show high (Red-bellied Fruit-Dove Ptilinopus greyii), average (Melanesian Flycatcher Myiagra caledonica, Sacred Kingfischer Todiramphus sanctus) or low (Emerald Dove Chalcophaps indica) frequencies that remain comparable between these islands. The species ecology has been determined with some species associated with wide forests, e. g. the Ouvea Parakeet, while others are typical of the open settings. The threats onto this avifauna are mainly linked to habitat destruction and the impact of introduced species. A specific effort should be made to ensure the protection of populations of that species for which there is the greatest concern, i. e. the Ouvea Parakeet. | Revue d'Écologie (La Terre et La Vie) | [
"Ecology, Evolution, Behavior and Systematics"
] |
MCSCF‐CI calculations of infrared transition probabilities in the CH− and NH− ions | The Journal of Chemical Physics | [
"Physical and Theoretical Chemistry"
] | |
KASSELER MUSIKTAGE: BACH IM 20. JAHRHUNDERT | [
"Music"
] | ||
The construction and turnover of complex community models having Generalized Lotka-Volterra dynamics | [
"Applied Mathematics",
"Modeling and Simulation",
"Statistics and Probability"
] | ||
1,4-Disilabenzol. - Dimethoxysilylen als idealer synthesebaustein | [
"Organic Chemistry",
"Drug Discovery",
"Biochemistry"
] | ||
COVID-19 nationwide lockdown and it’s emotional stressors among Malaysian women | [
"Social Sciences (miscellaneous)"
] | ||
DEEP PLACEMENT OF FERTILIZER SOLUTION IN PUDDLED SOILS PART 2: RICE GROWTH AND YIELD | [
"Agricultural and Biological Sciences (miscellaneous)"
] | ||
Growth potential of aortic autografts and allografts: effects of cryopreservation and immunosuppression in an experimental model | [
"Cardiology and Cardiovascular Medicine",
"Pulmonary and Respiratory Medicine",
"Surgery"
] | ||
Genetic Elimination of Prothrombin in Adult Mice Results in Fatal Spontaneous Hemorrhage in the Heart and Central Nervous System | Abstract Thrombin-mediated proteolysis is central to hemostasis, directly controlling both platelet activation and fibrin deposition as well as positively- and negatively-regulating further thrombin generation through the activation of factors XI, VIII, V and protein C. Thrombin also appears to be important in multiple processes distinct from traditional hemostasis, but detailed genetics-based studies have been impeded by the uniform embryonic and perinatal failure of mice with constitutive prothrombin (fII) deficiency. To develop an experimental setting to explore the importance of fII in vascular biology, tissue repair, the inflammatory response and disease processes in adult animals, we have generated mice carrying a conditional prothrombin knockout allele (fIIlox). In the absence of Cre-mediated recombination, homozygous fIIlox/lox mice or compound heterozygous mice carrying one fIIlox allele and one constitutive-null allele were found to carry ~20% and ~10% the normal level of circulating prothrombin, respectively. These fIIlox/lox and fIIlox/− mice exhibited normal developmental and reproductive success, survived well into adulthood and young adults exhibited no appreciable spontaneous bleeding events or other pathologies. However, one-year-old fIIlox/− mice developed modest focal hemosiderin deposits and fibrosis within the heart, consistent with chronic low grade hemorrhage in this tissue. No gross or microscopic pathologies were observed in any other tissue examined in mice carrying an intact conditional knockout allele, regardless of age or gender. The induction of Cre recombinase in adult fIIlox mice using the poly I:C-inducible Mx1-Cre system resulted in the rapid and near-complete recombination of the fIIlox allele within the liver, loss of hepatic fII mRNA, elimination of detectable circulating prothrombin, and profound derangements in coagulation function. The life-expectancy in adults genetically-depleted of prothrombin was found to be very short (generally 5–7 days), and the loss of viability was associated with the development of severe hemorrhagic events within multiple tissues, most prominently in the heart (100% phenotypic penetrance) and brain (~50% phenotypic penetrance). Microscopic analysis of hearts from mice following deletion of the fII allele revealed widespread hemorrhage within the myocardium, particularly in the subepicardial region, focal ischemia and necrosis, neutrophil infiltrates and early granulation tissue. Gross evidence of blood was observed within the pleural cavity in nearly half of Cre-induced fIIlox/− mice at autopsy, and the lack of appreciable hemorrhage within lung tissue favored the heart as the source of this free blood. Less common hemorrhagic events were observed several other tissues, including skeletal muscle, intestines and testes. Examination of brains from mice lacking fII revealed widespread bleeding in the central nervous system, including dural-based hemorrhage and bleeding into both the brain parenchyma and ventricles. These results imply that a robust hemostatic system is essential to limit spontaneous bleeding events in tissues under repetitive mechanical or pulsatile stress. These findings also demonstrate that low levels of fII are compatible with long-term survival in adult mice, affording the ability to examine fII in a diverse spectrum of disease and physiologic processes. As evidence of this concept, mice lacking fII were challenged with S. aureus peritonitis prior to the onset of hemorrhage. Similar to mice lacking fibrinogen, these animals were found to have a profound deficit in their ability to control this infection, pointing to the need for polymerized fibrin for the effective clearance of this bacteria from the peritoneal cavity. | Blood | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] |
The topology of certain Riemannian manifolds with positive Ricci curvature | Journal of Differential Geometry | [
"Geometry and Topology",
"Algebra and Number Theory",
"Analysis"
] | |
Interferometric method for birefringence determination with a polarizing microscope | Optics Express | [
"Atomic and Molecular Physics, and Optics"
] | |
Adaptive Switching Scheme for RS Overhead Reduction in Massive MIMO With Industrial Internet of Things | IEEE Internet of Things Journal | [
"Computer Networks and Communications",
"Computer Science Applications",
"Hardware and Architecture",
"Information Systems",
"Signal Processing"
] | |
BOOK REVIEW | [
"Sociology and Political Science"
] | ||
Laryngotracheitis (gallid‐1) herpesvirus infection in the chicken 4. latency establishment by wild and vaccine strains of ILT virus | [
"Animal Science and Zoology",
"Food Animals"
] | ||
Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40 | [
"Inorganic Chemistry",
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Computer Science Applications",
"Spectroscopy",
"Molecular Biology",
"Catalysis"
] | ||
Study of photon dominated regions in IC 348 | AbstractWe present fine structure line of neutral carbon at 492 GHz (3P1–3P0, hereafter [C I] 1–0) and 12CO 4–3 KOSMA observations. This data has been combined with FCRAO 12CO 1–0 and 13CO 1–0 data. We have used these observations to understand the emission from the photon dominated regions (PRDs) in IC 348. We confirm the anti-correlation between N(C)/N(CO) and N(H2) as seen in most Galactic PDRs (Mookerjea et al. 2006). | Proceedings of the International Astronomical Union | [
"Astronomy and Astrophysics",
"Space and Planetary Science"
] |
Studies on the biosynthesis of carbapenem antibiotics. IV. .BETA.-Alanine in the C-3 pantetheinyl side chain of the OA-6129 group of carbapenems. | [
"Drug Discovery",
"Pharmacology"
] | ||
Notes on contributors | [
"Political Science and International Relations",
"Development",
"Geography, Planning and Development"
] | ||
Bigwood Systems | [
"Electrical and Electronic Engineering",
"Energy Engineering and Power Technology"
] | ||
Chronic maternal methanol inhalation in nonhuman primates (Macaca fascicularis): reproductive performance and birth outcome | Neurotoxicology and Teratology | [
"Cellular and Molecular Neuroscience",
"Developmental Neuroscience",
"Toxicology"
] | |
Kitap Tenkitleri : MUZAFFER SENCER'İN ALLAHIN VARLIĞINA DAİR BİR KİTABI | [
"Religious Studies"
] | ||
Detection of amoxicillin residues in egg extract with a molecularly imprinted polymer on gold microchip using surface plasmon resonance and quartz crystal microbalance methods | Journal of Food Science | [
"Food Science"
] | |
Magnetic permeability aftereffect in amorphous CoMn alloys | [
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | ||
Study on Evaluation of Fatigue Damage of MIM Materials with AE Method : 2nd Report, Evaluation by Moving Average of Largest Lyapunov Exponent | [
"Mechanical Engineering",
"Mechanics of Materials"
] |
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