Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Trimethyl 4,6-Dicyano-5-hydroxybenzene-1,2,3-tricarboxylate | [
"Organic Chemistry",
"Physical and Theoretical Chemistry",
"Biochemistry"
] | ||
Stokes, Urkeltischer Sprachschatz | [
"Linguistics and Language",
"Language and Linguistics"
] | ||
Razvoj veb aplikacije za nadzor i upravljanje sistemom pametnog osvetljenja i utičnica | U ovom radu opisan je razvoj veb aplikacije za nadzor i upravljanje sistemom pametnog osvjetljenja i pametnih utičnica jednog kućnog okruženja. Aplikacija je razvijena u cilju praćenja, kontrole i smanjenja energetske potrošnje. Komunikacija između pojedinačnih pametnih uređaja i servera implementirana je putem MQTT protokola, dok je veb aplikacija razvijena u Ignition softverskoj platformi za razvoj SCADA sistema. | [
"Industrial and Manufacturing Engineering"
] | |
The Use of Rectal Misoprostol as Active Pharmacological Management of the Third Stage of Labor | [
"Obstetrics and Gynecology"
] | ||
Highlights | [
"Cell Biology"
] | ||
LivWell: a sub-national Dataset on the Living Conditions of Women and their Well-being for 52 Countries | AbstractData on women’s living conditions and socio-economic development are important for understanding and addressing the pronounced challenges and inequalities faced by women worldwide. While such information is increasingly available at the national level, comparable data at the sub-national level are missing. We here present the LivWell global longitudinal dataset, which includes a set of key indicators on women’s socio-economic status, health and well-being, access to basic services and demographic outcomes. It covers 447 regions in 52 countries and includes a total of 265 different indicators. The majority of these are based on 199 Demographic and Health Surveys (DHS) for the period 1990–2019 and are complemented by extensive information on socio-economic and climatic conditions in the respective regions. The resulting dataset offers various opportunities for policy-relevant research on gender inequality, inclusive development and demographic trends at the sub-national level. | [
"Library and Information Sciences",
"Statistics, Probability and Uncertainty",
"Computer Science Applications",
"Education",
"Information Systems",
"Statistics and Probability"
] | |
On The Power Function Of Bayesian Tests With Application To Design Of Clinical Trials: The Fixed-Sample Case | [
"Statistics, Probability and Uncertainty",
"Statistics and Probability"
] | ||
Rembrandts Gemälde “Der polnische Reiter” in Antonio Muñoz Molinas El jinete polaco | [
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
Performance of a Windblown-Particle Sampler | [
"Agricultural and Biological Sciences (miscellaneous)"
] | ||
5169 Comparison and combination of gene-set classifiers for prediction of localized breast cancer survival | [
"Cancer Research",
"Oncology"
] | ||
医用生体工学研究の最前線― | The Journal of The Institute of Electrical Engineers of Japan | [
"Electrical and Electronic Engineering"
] | |
Le Reflet de la Psychiatrie dans le Miroir de la Littérature Universelle | American Journal of Psychotherapy | [
"Clinical Psychology"
] | |
Consumer behaviour: Behavioural aspects of marketing | [
"Marketing"
] | ||
Real and perceived barriers to steel reuse across the UK construction value chain | Resources, Conservation and Recycling | [
"Economics and Econometrics",
"Waste Management and Disposal"
] | |
Vitamins, Minerals, Supplements and Dietary Approaches | Focus on Alternative and Complementary Therapies | [
"Complementary and Alternative Medicine"
] | |
Strategic stages in subsistence small businesses: the case of the timber industry in Misiones (Argentine) | [
"Economics and Econometrics",
"Renewable Energy, Sustainability and the Environment",
"Business and International Management"
] | ||
Divergent flow in contractions | Journal of Non-Newtonian Fluid Mechanics | [
"Applied Mathematics",
"Mechanical Engineering",
"Condensed Matter Physics"
] | |
Marital Conflict and Acculturation Among Mexican American Husbands and Wives. | [
"Sociology and Political Science",
"Social Psychology"
] | ||
Pubertal development in the male buffalo: Longitudinal analysis of body growth, testicular size and serum profiles of testosterone and oestradiol | Animal Reproduction Science | [
"Endocrinology",
"Animal Science and Zoology",
"Food Animals"
] | |
Associations of Suicide Prevention Trainings with Practices and Confidence among Clinicians at Community Mental Health Centers | Suicide and Life-Threatening Behavior | [
"Psychiatry and Mental Health",
"Public Health, Environmental and Occupational Health",
"Clinical Psychology"
] | |
Editorial Commentary: The Benefits of Three-Dimensional Computed Tomography Images to Evaluate the Safety of All-Inside Meniscal Repair | [
"Orthopedics and Sports Medicine"
] | ||
PT286 The Effect of Physical Activity on Cholesterol Levels in Older Australians | Global Heart | [
"Cardiology and Cardiovascular Medicine",
"Community and Home Care",
"Epidemiology"
] | |
Safety and Efficacy of Eltrombopag in Children and Adults with Immune Thrombocytopenia: A Systematic Review and Meta-Analysis | Immune thrombocytopenia is an immune condition where antibodies are produced against platelets. Eltrombopag is a thrombopoietin receptor agonist that stimulates and promotes platelet production approved for treating thrombocytopenia in patients with chronic immune thrombocytopenia, where other treatments such as corticosteroids, splenectomy or immunoglobulins are inadequate. The aim of this meta-analysis was to evaluate the efficacy and safety of the eltrombopag in adults and children with immune thrombocytopenia. We included 7 studies with a total of 765 patients (606 adults and 159 children). We evaluated the number of patients that achieved a post-treatment platelet count equal or above 50x109/L (primary result-target) without the need of rescue treatment for at least 4 weeks. Our data showed that patients who received eltrombopag were almost 4 times more probable in achieving the primary target when compared to patients who received placebo (RR 3.84, 95% CI 2.39 to 6.14; I2 = 46%). The number of patients needed rescue treatment and the number of bleeding incidents were reduced in the group that received eltrombopag when compared to those who received placebo (RR 0.40, 95% CI 0.25 to 0.62; I2 = 40%) (RR 0.74, 95% CI 0.62 to 0.89; I2 = 68%). The total number of side effects did not statistically differ between the two groups (RR 0.99, 95% CI 0.90 to 1.08; I2 = 14%). Our findings were similar to previously published studies and confirm that eltrombopag is safe and efficient in immune thrombocytopenia. However, more clinical trials are needed in order to enhance our findings. | [
"Cardiology and Cardiovascular Medicine",
"Pharmacology",
"Hematology"
] | |
Nose. The black American nose | Plastic and Reconstructive Surgery | [
"Surgery"
] | |
American Diplomacy: Its Spirit and Achievements. By John Bassett MooreLL.D., Professor of International Law and Diplomacy in Columbia University. New York and London: Harper and Brothers. pp. xii, 286. 1905. | American Journal of International Law | [
"Law",
"Political Science and International Relations"
] | |
Therapeutic opportunities based on caspase modulation | [
"Cell Biology",
"Developmental Biology"
] | ||
SHORTER NOTICES | [
"History"
] | ||
Entre Marx y Freud: el totalitarismo según Serge, Fromm y Marcuse | Victor Serge, Erich Fromm y Herbert Marcuse elaboraron una primera interpretación acerca de los totalitarismos nazi y soviético. La particularidad de sus escritos al inicio de 1940 fue entrelazar conceptos marxistas y psicoanalíticos para comprender la racionalidad que subyacía a estos dos fenómenos. En paralelo, hicieron propuestas para renovar el socialismo en un sentido democrático. Coinciden en plantear que además de la represión política y del control burocrático, la dominación totalitaria se ejercía a través de un potente aparato ideológico que había arraigado en el inconsciente individual y colectivo. Consideraron que la importancia del trabajo intelectual estaba ligada a la comprensión de los mecanismos psicológicos que sustentaban el fenómeno totalitario a fin de erradicarlo. | Estudios Sociológicos de El Colegio de México | [
"Political Science and International Relations",
"Sociology and Political Science"
] |
SOCIOLOGY AS DISCIPLINE AND AS PROFESSION: A SOCIOLOGICAL SCRATCH FOR EVERY SOCIAL ITCH? | The relationship between research pursued in sociology as an academic discipline and sociological research undertaken as a contribution toward social policy formation is a somewhat uneasy one in the USA. The author undertakes to examine the evolving relationship between the disciplinary and professional thrusts of the American sociological enterprise. | [
"Sociology and Political Science"
] | |
Unique Nonmagnetic-Magnetic Transition in Sm-Based Compounds: 33S-NMR Study on SmS | [
"Condensed Matter Physics"
] | ||
Sucrose Malabsorption and Impaired Mucosal Integrity in Enterally Fed Critically Ill Patients | Critical Care Medicine | [
"Critical Care and Intensive Care Medicine"
] | |
Acoustic source localization in ocean waveguides using principles of Riemannian geometry | [
"Acoustics and Ultrasonics",
"Arts and Humanities (miscellaneous)"
] | ||
Hydromagnetic Stability of a Plane Vortex Sheet in Finitely Conducting Fluids | [
"Applied Mathematics",
"Computational Mechanics"
] | ||
The teaching of equations | [
"Education"
] | ||
EVALUATION OF THE INFLUENCE OF ACCELERATED CARBONATION ON THE BOND STRENGTH BETWEEN ALC AND CERAMIC TILES | [
"Building and Construction",
"Architecture"
] | ||
A novel HLA‐C *15 allele, HLA‐C *15:192 , identified by next generation sequencing in a Chinese individual | [
"Genetics",
"Immunology",
"Immunology and Allergy"
] | ||
Social inequalities in health: measuring the contribution of housing deprivation and social interactions for Spain | [
"Public Health, Environmental and Occupational Health",
"Health Policy"
] | ||
Terms of Address: Problems of Patterns and Usage in Various Languages and Cultures | [
"Linguistics and Language",
"Language and Linguistics"
] | ||
Preface | Acta Neurologica Scandinavica | [
"Neurology (clinical)",
"Neurology"
] | |
Construct Validity of Three Types of Organizational Citizenship behavior: An Illustration of the Direct Product Model with Refinements | The direct product model is a new analysis tool for modeling multitrait-multimethod data. This model may avoid some of the problems associated with conventional analysis of multitrait-multimethod data by allowing for the possibility of multiplicative trait-method interactions. Based on the work of Browne (1984; 1990), we suggest several refinements in testing this model, including use of confirmatory procedures for testing model fit and implementation of a hierarchical approach to model comparisons. We provide an illustration of the refined direct product approach using a study of three types of organizational citizenship behavior. The results supply evidence for convergent and discriminant validity of the three constructs, and suggest that job incumbents, supervisors, and peers have significantly different perspectives of organizational citizenship behavior. | [
"Strategy and Management",
"Finance"
] | |
Injection moulding of plastics: Some ideas about the relationship between mould filling and birefringence | [
"Condensed Matter Physics"
] | ||
Elsewhere and otherwise: Indigeneity and the politics of exclusion in Labrador's extractive resource governance | [
"Management, Monitoring, Policy and Law",
"Economic Geology",
"Development",
"Geography, Planning and Development"
] | ||
Staff List | [
"Electrical and Electronic Engineering",
"Computer Networks and Communications"
] | ||
Influence of Vegetation and Hydrology on the Humus Budgets of Labrador Lakes | A mass-balance approach is used to explore the effect of several hydrologic and geographic variables on humic matter concentrations in surface waters of Labrador–Ungava. Water-color measurements from 67 dilute oligotrophic lakes are used to evaluate model predictions of aquatic humus concentration from basin hydrology, catchment vegetation, and internal loss rates. The major trend in water color in the Labrador region — increasing north to south — results from differences in external humus loading from catchment vegetation and soils. Hydrologic influences on aquatic humus concentrations reside in the dilution of catchment drainage by direct precipitation to the lake — effective only when catchments are small — and in water residence time which controls losses due to mineralization and sedimentation. | [
"Aquatic Science",
"Ecology, Evolution, Behavior and Systematics"
] | |
Elective total knee arthroplasty in haemophilic patients | SummaryTotal knee arthroplasty (TKA) provides significant pain relief and better function in patients with end-stage haemophilic knee arthropathy. Peri- and postoperative care tends to be more complex than in non-haemophilic patients undergoing TKA and requires a multidisciplinary team approach. Aim: The implementation of standardized clinical pathways in non-haemophilic patients undergoing TKA has been shown to increase quality of care and to reduce postoperative complication rates. Consequently, the use of clinical pathways in haemophilic patients undergoing TKA may be beneficial to this particular subpopulation of patients. Methods: A clinical pathway for TKA for haemophilic patients was designed in a consensus process involving all participating departments. Results: We propose a specifically adjusted clinical pathway for TKA for haemophilic patients to show that standardization of elective orthopaedic surgery in haemophilia is feasible. Conclusion: The authors emphasize that there are limitations on categorizing haemophilic patients and stress that individual interdisciplinary treatment should take precedence over a standardized approach. | Hämostaseologie | [
"Hematology"
] |
Modeling and impact of gear train backlash on performance of DFIG wind turbine system | [
"Electrical and Electronic Engineering",
"Energy Engineering and Power Technology"
] | ||
Ubiquitous Personal Study: a framework for supporting information access and sharing | [
"Management Science and Operations Research",
"Computer Science Applications",
"Hardware and Architecture"
] | ||
Willingness to compete: Between‐ and within‐gender comparisons | [
"Management of Technology and Innovation",
"Management Science and Operations Research",
"Strategy and Management",
"Business and International Management"
] | ||
Suppression of the Estradiol Receptor System by Progesterone in the Oviduct and Uterus of the Cat12 | Endocrinology | [
"Endocrinology"
] | |
How Far is the Concept of Isolated Active Sites Valid in Solid Catalysts? | Topics in Catalysis | [
"Catalysis"
] | |
Reliability of Automatic Biometric Iris Recognition after Phacoemulsification or Drug-Induced Pupil Dilation | Purpose To investigate the reliability of a biometric iris recognition system for personal authentication after cataract surgery or iatrogenic pupil dilation. Methods This was a prospective, nonrandomized, single-center, cohort study for evaluating the performance of an iris recognition system 2–24 hours after phacoemulsification and intraocular lens implantation (group 1) and before and after iatrogenic pupil dilation (group 2). Results Of the 173 eyes that could be enrolled before cataract surgery, 164 (94.8%) were easily recognized postoperatively, whereas in 9 (5.2%) this was not possible. However, these 9 eyes could be reenrolled and afterwards recognized successfully. In group 2, of a total of 184 eyes that were enrolled in miosis, a total of 22 (11.9%) could not be recognized in mydriasis and therefore needed reenrollment. No single case of false-positive acceptance occurred in either group. Conclusions The results of this trial indicate that standard cataract surgery seems not to be a limiting factor for iris recognition in the large majority of cases. Some patients (5.2% in this study) might need “reenrollment” after cataract surgery. Iris recognition was primarily successful in eyes with medically dilated pupils in nearly 9 out of 10 eyes. No single case of false-positive acceptance occurred in either group in this trial. It seems therefore that iris recognition is a valid biometric method in the majority of cases after cataract surgery or after pupil dilation. | European Journal of Ophthalmology | [
"Ophthalmology"
] |
Regulated Phosphatidylserine Exposure on Platelets Mediates Fibrin Formation in Hemostasis and Thrombosis. | Abstract Thrombin-stimulated platelets support activity of phosphatidylserine (PS)-dependent blood coagulation reactions. However, only 2–6% of stimulated platelets expose sufficient PS to bind annexin V, leading to the supposition that procoagulant reactions are localized to the annexin V positive platelets and to microparticles shed by platelets. We hypothesized that thrombin-stimulated platelets expose sufficient PS to support the prothrombinase and factor Xase complexes but insufficient to meet the threshold for annexin V binding. We evaluated lactadherin, a PS-binding milk protein, as a reagent to detect platelet PS exposure. Thrombin or TRAP-treated platelets bound lactadherin with 3200 ± 700 sites/plt, but did not bind annexin V, as detected by flow cytometry. To confirm that lactadherin binding truly reported PS exposure, we performed activation experiments upon platelets loaded with 1-Palmitoyl-2- [6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-sn-Glycero-3-Phospho-L-Serine (NBD-PS). Stimulation of platelets with 10 μM TRAP led to 8 ± 2 % PS exposure vs > 90% PS exposure for 10 μM A23187. PS exposure was maximal within 1 min of exposure to TRAP and was reversible with >70% of exposed PS re-internalized within 30 min. In situ platelet fibrin deposition was monitored utilizing a novel flow cytometry assay. Platelet rich plasma was recalcified and supplemented with 50 pM factor Xa, 100 μM GPRP. Platelet-bound fibrin, lactadherin and annexin V binding sites were measured at time intervals. Fibrin accumulated on lactadherin + platelets at a rate greater than or equal to the rate on platelet microparticles or annexin V + platelets. Lactadherin inhibited > 98% of prothrombinase and factor Xase activity on platelets while annexin V inhibition reached a plateau of ~ 80%. The localization and importance of regulated PS exposure in vivo was evaluated in mouse models. Anesthetized mice were injected intravenously with 1 μg of lactadherin and 1 μg annexin V. Three minutes after FeCl3 injury of exposed mesentery, mice were perfused with fixative. Immunohistochemistry showed veins edged with fibrin and decorated with platelets. Lactadherin co-localized with CD41+ platelets along the vascular wall but was less intense on platelets lodged within fibrin aggregates that extended into the vessel lumen and did not stain platelets in sequestered blood. Annexin V stained only scattered platelets and endothelial cells and did not correlate well to sites of fibrin deposition. To evaluate the hemostatic importance of platelet PS, 10 μg of lactadherin was injected intravenously prior to tail snip; bleeding volumes increased from 33 ± 29 μl to 128 ± 39 μl, n experimental = 8. Rose bengal/laser-induced carotid thrombosis delayed from 34 ± 9 min to 80 ± 20 min, n = 10 after 8–21 μg lactadherin. Four treated animals did not develop a thrombosis. In summary, use of lactadherin as a PS probe has revealed that the capacity for regulated PS exposure, at levels below the annexin V binding threshold, is a general platelet property and that low level PS exposure is sufficient to support thrombin and fibrin generation in vitro and in vivo. These results have implications about the mechanism through which PS exposure is regulated as well as for the potential value of PS exposure as a diagnostic or therapeutic target. | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] | |
Reactivation of Latent Cytomegalovirus Infection in Mouse Brain Cells Detected after Transfer to Brain Slice Cultures | ABSTRACT Cytomegalovirus (CMV) is the most significant infectious cause of brain disorders in humans involving the developing brain. It is hypothesized that the brain disorders occur after recurrent reactivation of the latent infection in some kinds of cells in the brains. In order to test this hypothesis, we examined the reactivation of latent murine CMV (MCMV) infection in the mouse brain by transfer to brain slice culture. We infected neonatal and young adult mice intracerebrally with recombinant MCMV in which the lacZ gene was inserted into a late gene. The brains were removed 6 months after infection and used to prepare brain slices that were then cultured for up to 4 weeks. Reactivation of latent infection in the brains was detected by β-galactosidase (β-Gal) staining to assess β-galactosidase expression. Viral replication was also confirmed by the plaque assay. Reactivation was observed in about 75% of the mice infected during the neonatal period 6 months after infection. Unexpectedly, reactivation was also observed in 75% of mice infected as young adults, although the infection ratio in the brain slices was significantly lower than that in neonatally infected mice. β-Gal-positive cells were observed in marginal regions of the brains or immature neural cells in the ventricular walls. Immunohistochemical staining showed that the β-Gal-positive reactivated cells were neural stem or progenitor cells. These results suggest that brain disorders may occur long after infection by reactivation of latent infection in the immature neural cells in the brain. | Journal of Virology | [
"Virology",
"Insect Science",
"Immunology",
"Microbiology"
] |
PREGNANCY OUTCOMES BY DEGREE OF EXPANSION IN THAWED HIGH QUALITY EMBRYOS | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | ||
PureCell systems for East Conn university, UTC Power HQ | [
"Strategy and Management",
"Energy Engineering and Power Technology",
"Renewable Energy, Sustainability and the Environment"
] | ||
Corrosion Calender – Materials and Corrosion 4/2006 | [
"Materials Chemistry",
"Metals and Alloys",
"Surfaces, Coatings and Films",
"Mechanical Engineering",
"Mechanics of Materials",
"Environmental Chemistry"
] | ||
Teaching Bits: Statistics Education Articles from 2015 | [
"Statistics, Probability and Uncertainty",
"Education",
"Statistics and Probability"
] | ||
Geometric features in lyotropic liquid crystalline phase transitions observed in aqueous surfactant systems | [
"Polymers and Plastics",
"Surfaces, Coatings and Films",
"Physical and Theoretical Chemistry"
] | ||
Modeling bidirectional pedestrian flow with the perceived uncertainty of preceding pedestrian information | [
"Statistical and Nonlinear Physics",
"Statistics and Probability"
] | ||
RNA Editing of Wheat Mitochondrial ATP Synthase Subunit 9: Direct Protein and cDNA Sequencing | [
"Cell Biology",
"Plant Science"
] | ||
Child Labour in a Rural Non-Farm Sector – A Study of the Silk Reeling Industry | Child labour must not be tolerated in any form and must be prevented and eliminated. It is imperative to abolish the most exploitative and intolerable forms of child labour as a first priority. - The UN System in India Silk reeling is one of those small scale hazardous industries in which child labour is dominant in India. A detailed study made in Ramanagaram, a reeling centre in Karnataka, shows that about 50 per cent of the workers are children below 14, working for a pittance, a major human tragedy. The responsibility for this tragedy lies both with the parents and the owners of the reeling units. Most of the children are eager to go to school and with the help of the state government and some NGOs, a bridge course has been started to help them fulfil their desires. Some live case studies document the facts uncovered. | [
"Organizational Behavior and Human Resource Management",
"Industrial Relations",
"Business and International Management"
] | |
Statistical size effect on multiaxial fatigue strength of notched steel components | [
"Industrial and Manufacturing Engineering",
"Mechanical Engineering",
"Mechanics of Materials",
"Modeling and Simulation"
] | ||
Environmental impact assessment of lignocellulosic lactic acid production: Integrated with existing sugar mills | [
"Biochemistry",
"Food Science",
"Biotechnology"
] | ||
Penetrance of HFE-related hemochromatosis in perspectiveW | Hepatology | [
"Hepatology"
] | |
Baumanagement - veränderte Anforderungen durch den Einfluß von Umweltbelangen | [
"Building and Construction",
"Civil and Structural Engineering"
] | ||
Xylem Inc, USA | [
"Industrial and Manufacturing Engineering",
"Filtration and Separation"
] | ||
High-dose chemotherapy in soft tissue sarcoma in children | [
"Oncology",
"Hematology"
] | ||
Membrane Reactor for Methanol Synthesis Using Si-Rich LTA Zeolite Membrane | We successfully demonstrated the effect of a membrane reactor for methanol synthesis to improve one-pass CO2 conversion. An Si-rich LTA membrane for dehydration from a methanol synthesis reaction field was synthesized by the seed-assisted hydrothermal synthesis method. The H2O permselective performance of the membrane showed 1.5 × 10−6 mol m−2 s−1 Pa−1 as H2O permeance and around 2000 as selectivity of H2O/MeOH at 473 K. From the results of membrane reactor tests, the CO2 conversion of the membrane reactor was higher than that of the conventional packed-bed reactor under the all of experimental conditions. Especially, at 4 MPa of reaction pressure, the conversion using the membrane reactor was around 60%. In the case of using a packed-bed reactor, the conversion was 20% under the same conditions. In addition, the calculated and experimental conversion were in good agreement in both the case of the membrane reactor and packed-bed reactor. | [
"Filtration and Separation",
"Chemical Engineering (miscellaneous)",
"Process Chemistry and Technology"
] | |
Distribution of VA Mycorrhizal Fungi Along a Latitudinal Temperature Gradient | Mycologia | [
"Cell Biology",
"Genetics",
"Molecular Biology",
"Physiology",
"Ecology, Evolution, Behavior and Systematics"
] | |
Chromospheric Heating in the Late Phase of Two‐Ribbon Flares | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | ||
Letter from Tokyo | [
"Literature and Literary Theory",
"Visual Arts and Performing Arts",
"Cultural Studies"
] | ||
Studies on the profile of desmethylimipramine as a gastric antisecretory agent | [
"Drug Discovery"
] | ||
Geochemical Features, Age, and Tectonic Significance of the Kekekete Mafic-ultramafic Rocks, East Kunlun Orogen, China | [
"Geology"
] | ||
A Novel Route to 1-Azaazulenes by the Reaction of b-Amino Enones with Activated Tropones | [
"Organic Chemistry",
"Pharmacology",
"Analytical Chemistry"
] | ||
A review of the electronic and magnetic properties of tetrahedrally bonded half-metallic ferromagnets | [
"Condensed Matter Physics"
] | ||
Production of triploid plants of mulberry ( Morus alba L) by endosperm culture | Plant Cell Reports | [
"Plant Science",
"Agronomy and Crop Science"
] | |
Planar Broadband Slot Radiating Element Based on Microstrip-Slot Coupling for Series-fed Arrays | [
"Electrical and Electronic Engineering"
] | ||
Future Generations and the Metaphysics of the Self: Western and Indian philosophical perspectives | [
"Philosophy",
"Religious Studies"
] | ||
Innovative genomic-based model for personalized treatment of gastric cancer: integrating current standards and new technologies | Expert Review of Molecular Diagnostics | [
"Genetics",
"Molecular Biology",
"Molecular Medicine",
"Pathology and Forensic Medicine"
] | |
Modeling thermophoretic effects in solid-state nanopores | [
"Electrical and Electronic Engineering",
"Modeling and Simulation",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Respuestas agudas al entrenamiento de fuerza con cargas pesadas y al entrenamiento mediante estiramiento sobre el rendimiento en squat jump y countermovement jump. (Acute affects of strenght training from heavy loads and static stretching training on squat jump and countermovement jump). | RICYDE. Revista internacional de ciencias del deporte | [
"Physical Therapy, Sports Therapy and Rehabilitation"
] | |
A critical review of principal traffic noise models: Strategies and implications | [
"Management, Monitoring, Policy and Law",
"Ecology",
"Geography, Planning and Development"
] | ||
Relationship between perceived politeness and spectral characteristics of voice | [
"Acoustics and Ultrasonics",
"Arts and Humanities (miscellaneous)"
] | ||
Phenomenes galvanomagnetiques non lineaires en limite quantique | [
"Condensed Matter Physics"
] | ||
A Gene Expression Based Proliferation Index as Independent Prognostic Factor in Multiple Myeloma. | Abstract BACKGROUND. The proliferation-rate of primary myeloma cells is a strong adverse prognostic factor in various trials, but not routinely assessed, partially due to effort in obtaining it. AIM. As gene-expression profiling is increasingly considered a standard diagnostics in myeloma, we investigated the possibility to develop a prognostically relevant gene-expression based proliferation index (GPI). PATIENTS AND METHODS. Gene expression was determined by Affymetrix DNA-microarrays in 784 samples including two independent sets of 233 and 345 CD138-purified myeloma cells from previously untreated patients. The GPI was derived by selecting genes associated with proliferation (in terms of gene ontology) differentially expressed in proliferating malignant (human myeloma cell lines) and benign (plasmablastic) cells compared to non-proliferating, non-malignant cells (normal plasma cells and memory B-cells). The GPI comprises the sum of the expression values of 50 genes (ASPM, AURKA, AURKB, BIRC5, BRCA1, BUB1, BUB1B, CCNA2, CCNB1, CCNB2, CDC2, CDC20, CDC25C, CDC6, CDCA8, CDKN3, CEP55, CHEK1, CKS1B, CKS2, DLG7, ESPL1, GINS1, GTSE1, KIAA1794, KIF11, KIF15, KIF20A, KIF2C, KNTC2, MAD2L1, MCM10, MCM6, MKI67, NCAPD3, NCAPG, NCAPG2, NEK2, NPM1, PAK3, PCNA, PGAM1, PLK4, PTTG1, RACGAP1, SMC2, SPAG5. STIL, TPX2, ZWINT). Proliferation of primary myeloma cells was assessed by propidium iodinestaining (n=67). Chromosomal aberrations were assessed by comprehensive iFISH using a set of probes for the chromosomal regions 1q21, 6q21, 8p21, 9q34, 11q23, 11q13, 13q14.3, 14q32, 15q22, 17p13, 19q13, 22q11, as well as the translocations t(4;14)(p16.3;q32.3) and t(11;14)(q13;q32.3). RESULTS. In the two groups, 39 and 32 percent of primary myeloma cells show a GPI above the median plus three standard deviations of normal bone marrow plasma cells, respectively. The GPI is significantly higher in advanced- compared to early-stage myeloma (P=.001) and in patients harboring a gain of 1q21 (n=95, P<0.001). It correlates significantly with proliferation as determined by propidium iodine in primary myeloma cells (rs=.52, P<.001, n=67). The GPI as continuous variable is significantly predictive for event-free survival (EFS, n=120, P<.001, n=345, P<.001, respectively) and overall survival (OAS, n=345, P<.001) in patients treated with high-dose chemotherapy, independent of serum-β2-microglobulin (B2M) or ISS-stage. A GPI above the median (GPIhigh) delineated significantly inferior EFS (n=168, 41.6 vs. 26 months, P=.04, HR 1.57, CI [1.02,2.42]; n=345, 68.6 vs. 45.2 months, HR 1.55, CI [1.16,2.09], P=.003) and OAS (n=345, P<.001) in two independent cohorts of patients undergoing high-dose chemotherapy. By using B2M above 3.5 mg/l and GPI as staging variables, four groups with difference in median EFS (n=345, B2M <3.5mg/l, GPIhigh/low 76.1 months; B2M < 3.5mg/l, GPIhigh 62.4 months, B2M ≥3.5mg/l, GPIlow 41.8 months, B2M ≥3.5mg/l, GPI 36.1 months, P<.001) and OAS can be delineated. CONCLUSION. The GPI represents a validated tool for the assessment of proliferation in multiple myeloma patients, allows a risk stratification in terms of proliferation either alone or in combination with B2M or ISS, respectively, and has the potential to be used within a risk adapted targeting of anti-proliferative treatment. | [
"Cell Biology",
"Hematology",
"Immunology",
"Biochemistry"
] | |
Increase in fluoride concentration in mine water in Shendong mining area, Northwest China: Insights from isotopic and geochemical signatures | Ecotoxicology and Environmental Safety | [
"Health, Toxicology and Mutagenesis",
"Public Health, Environmental and Occupational Health",
"Pollution"
] | |
Efficient amplification using the /sup 4/F/sub 3/2//spl rarr//sup 4/I/sub 9/2/ transition in Nd-doped silica fiber | [
"Electrical and Electronic Engineering",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Diversidad y distribución de los moluscos de agua dulce en la Comunidad de Madrid (España) | [
"Animal Science and Zoology",
"Ecology, Evolution, Behavior and Systematics"
] | ||
P.012 Virus Discovery-454 sequencing | [
"Infectious Diseases",
"Virology"
] | ||
Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice | [
"Cancer Research",
"Oncology"
] | ||
Effects of Domain Boundaries on the Diffraction Patterns of One-Dimensional Structures | Condensed Matter | [
"Condensed Matter Physics",
"Electronic, Optical and Magnetic Materials"
] | |
Bruker Instruments, Inc. | Analytical Chemistry | [
"Analytical Chemistry"
] | |
Blood histamine and cardiac activity | [
"Physiology"
] | ||
Metastatic Uveal Melanoma | [
"Ophthalmology"
] | ||
Power management in adjacent cognitive femtocells with distance-dependent interference in full coverage area | EURASIP Journal on Wireless Communications and Networking | [
"Computer Networks and Communications",
"Computer Science Applications",
"Signal Processing"
] | |
Enhancement of noisy EDX HRSTEM spectrum-images by combination of filtering and PCA | [
"Cell Biology",
"Structural Biology"
] | ||
Pelagic larvae of New England intertidal gastropods | Hydrobiologia | [
"Aquatic Science"
] | |
Impact of Fitness Status on the Optically Measured Hemodynamic Indexes | The physiological characteristics of skin blood flow can be described in terms of the hemodynamic indices (HI). The HI is derived from the laser speckle characteristics, which are governed by the cutaneous blood flow. A miniaturized dynamic light-scattering sensor was used to measure the speckle pattern from the finger root. Three groups of subjects from 15 to 25 years of age were tested. The first group included subjects who are actively engaged in sport activities; the second group included subjects with low level of physical activity; and the third group included healthy controls with moderate physical activity. The HI parameters were measured prior to and after the performance of a determined physical load. As a marker of cardiovascular fitness (CVF), we used the postload decay rate of HI. We found that the hemodynamic response to the physical load provides a statistically significant correlation with the postload heart rate decay. It was also found that postocclusion increase of the arterial HI is more prominent in the group with higher physical activity. These results indicate that hemodynamic indices can be used as an additional marker for cardiovascular fitness level. | [
"Health Informatics",
"Biomedical Engineering",
"Surgery",
"Biotechnology"
] | |
IFC - Editorial Board | Computer Communications | [
"Computer Networks and Communications"
] | |
“For Men of Our Time …” | [
"Health Policy",
"Philosophy"
] |
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