Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Phosphorescent Light–Emitting Iridium Complexes Serve as a Hypoxia-Sensing Probe for Tumor Imaging in Living Animals | Abstract Iridium complex is a promising organic light–emitting diode material for next generation video displays that emits phosphorescence quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia. Red light–emitting Ir(btp)2(acac) (BTP) presented hypoxia-dependent light emission in culture cell lines, whose intensity was in parallel with hypoxia-inducible factor-1α images. BTP was further applied to imaging five nude mouse transplanted with tumors. All tumors presented a bright BTP-emitting image even 5 minutes after injection. The minimal image recognition size was ∼2 mm in diameter. By morphologic examination and phosphorescence lifetime measurement, BTP appeared to localize to the tumor cells. Because BTP is easily modifiable, we synthesized BTP analogues with a longer excitation/emission wavelength. One of them, BTPHSA, depicted clear imaging from tumors transplanted 6 to 7 mm deep from the skin surface. We suggest that iridium complex materials have a vast potential for imaging hypoxic lesions such as tumor tissues. Cancer Res; 70(11); 4490–8. ©2010 AACR. | [
"Cancer Research",
"Oncology"
] | |
The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis | Our objective was to assess the point prevalence and effects of clinically significant anxiety in patients with Multiple Sclerosis (MS). One hundred and fifty two consecutive patients with MS attending an outpatient clinic underwent neurological examination and were assessed for psychopathology with the Hospital Anxiety and Depression Scale, the 28 item General Health Questionnaire and a questionnaire probing suicidal thoughts or intent. Clinically significant anxiety, either with or without depression, was endorsed by 25% of patients, three times the rate for depression. Females were significantly more anxious than males. Anxiety co-morbid with depression, rather than anxiety or depression alone, was associated with increased thoughts of self harm, more somatic complaints and greater social dysfunction. Patients with increased psychopathology were not more likely to be taking psychotropic medication. The results provide preliminary evidence that anxiety, which may be often overlooked clinically, is a frequent accompaniment to depression, thereby adding to the morbidity associated with MS. The implications of the findings to MS patients' quality of life are emphasised. | [
"Neurology (clinical)",
"Neurology"
] | |
Authoring a Self | [
"Philosophy"
] | ||
Portfolio assessment: direct from the classroom | [
"Education"
] | ||
Analytical solutions for lateral global buckling of deep-sea pipelines based on multi-stage soil resistance model | [
"Ocean Engineering",
"Geotechnical Engineering and Engineering Geology",
"Oceanography"
] | ||
Dr. Marmor Replies | [
"Psychiatry and Mental Health"
] | ||
Mechanical behavior of bio-inspired laminated composites | [
"Mechanics of Materials",
"Ceramics and Composites"
] | ||
Clasping Hands Across the Gulf: The Victorians and the Eighteenth Century | [
"Literature and Literary Theory",
"Cultural Studies"
] | ||
Particle Size Distribution Effects on Gas-Particle Mass Transfer within Electrostatic Precipitators | [
"Environmental Chemistry"
] | ||
Expression of ncRNAs on the DLK1-DIO3 Locus Is Associated With Basal and Mesenchymal Phenotype in Breast Epithelial Progenitor Cells | Frontiers in Cell and Developmental Biology | [
"Cell Biology",
"Developmental Biology"
] | |
Design and modeling of solenoid inductor integrated with FeNiCo in high frequency | TELKOMNIKA (Telecommunication Computing Electronics and Control) | [
"Electrical and Electronic Engineering"
] | |
Plasmonics: Graphene's bright future | [
"Condensed Matter Physics",
"Modeling and Simulation"
] | ||
Myocardial Function, Energy Provision, and Carnitine Deficiency in Experimental Uremia | [
"Nephrology"
] | ||
Peripheral production and decay angular distribution in the reaction | [
"Nuclear and High Energy Physics"
] | ||
Untersuchungen �ber den Wirkungsmechanismus von 2-(2,6-Dichlorphenylamino)-2-imidazolin-hydrochlorid (Catapresan, St 155) | Naunyn-Schmiedebergs Archiv f�r Pharmakologie und Experimentelle Pathologie | [
"Pharmacology"
] | |
Documents sur quelques langues peu connues de l'Amazone | [
"Anthropology",
"Cultural Studies"
] | ||
Third Annual Refresher Series | Radiology | [
"Radiology, Nuclear Medicine and Imaging"
] | |
Book Review: SALLY ENGLE MERRY, Human Rights and Gender Violence: Translating International Law into Local Justice. Chicago: University of Chicago Press, 2006, 264 pp., ISBN 978022652074, £35 (hbk) | [
"Law",
"Sociology and Political Science"
] | ||
Categorization Method for Nodes in Complex Networks and Its Application | [
"Artificial Intelligence",
"Software"
] | ||
Modern clinical syphilology. Diagnosis; treatment; case studies | [
"Surgery"
] | ||
Pustular Psoriasis | [
"Cell Biology",
"Dermatology",
"Molecular Biology",
"Biochemistry"
] | ||
Evolutionary Genetics of Hypoxia Tolerance in Cetaceans during Diving | [
"Genetics",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Detection of the power lines in UAV remote sensed images using spectral-spatial methods | [
"Management, Monitoring, Policy and Law",
"Waste Management and Disposal",
"Environmental Engineering"
] | ||
Maternal and child undernutrition 2: consequences for adult health and human capital | [
"Public Health, Environmental and Occupational Health",
"Developmental and Educational Psychology",
"Pediatrics, Perinatology and Child Health"
] | ||
F16 Postural assessment in dynamic posturography—a useful motor phenotype measure for presymptomatic and manifest Huntington's disease? | [
"Psychiatry and Mental Health",
"Neurology (clinical)",
"Surgery"
] | ||
Masthead | The Journal of Organic Chemistry | [
"Organic Chemistry"
] | |
New Applications of Phase Transfer Catalysis in Organic Synthesis | [
"Organic Chemistry"
] | ||
Influence of ambient gas on diamond-like carbon films prepared by KrF pulsed laser deposition | [
"Electrical and Electronic Engineering",
"Materials Chemistry",
"Mechanical Engineering",
"Electronic, Optical and Magnetic Materials"
] | ||
Foreword | [
"Endocrinology",
"Endocrinology, Diabetes and Metabolism"
] | ||
Experimentelle Reversion von Tumorzellen in vivo | [
"Cell Biology",
"Cellular and Molecular Neuroscience",
"Pharmacology",
"Molecular Biology",
"Molecular Medicine"
] | ||
Fully-geometric mesh one-leg methods for the generalized pantograph equation: Approximating Lyapunov functional and asymptotic contractivity | [
"Applied Mathematics",
"Computational Mathematics",
"Numerical Analysis"
] | ||
DENITRIFICATION OF AGRICULTURAL DRAINAGE USING WOOD-BASED REACTORS | [
"Soil Science",
"Agronomy and Crop Science",
"Biomedical Engineering",
"Food Science",
"Forestry"
] | ||
Dimethyl 1-(3-chloro-4-methylphenyl)pyrazole-3,4-dicarboxylate | [
"Condensed Matter Physics"
] | ||
Micellization of Sodium Perfluorodecanoate–Sodium 1-Decanesulfonate Mixture in Aqueous Solution | [
"Colloid and Surface Chemistry",
"Surfaces, Coatings and Films",
"Biomaterials",
"Electronic, Optical and Magnetic Materials"
] | ||
Poultry feeds carry diverse microbial communities that influence chicken intestinal microbiota colonisation and maturation | AbstractMicrobial colonisation of the gastrointestinal tract of newly hatched chicks starts at hatch, seeded from the immediate hatching environment, and quickly results in dense colonisation. The role of ecological factors in gut colonisation has been extensively investigated, as well as the role of micro- and macronutrients in supporting and selecting for bacterial species highly adapted for utilising those nutrients. However, the microbial community contained in poultry feed and its influence on colonisation and maturation of gut microbiota has not been directly addressed. In this study, we compared the microbiota found in poultry feed, with the microbiota of ileum, cecum and excreta, to identify substantial overlap in core microbiotas of the compared groups. We then investigated the microbiota present in raw feedstuffs: meat and bone meal, wheat, corn, canola, barley, soybean, millrun, sorghum, poultry oil, oats, limestone and bloodmeal from four geographically distinct feedstuff suppliers. Each of the feedstuffs had diverse microbial communities. The meat and bone meal and bloodmeal samples had the most complex and distinct microbial populations. There was substantial overlap in the phylogenetic composition found in the grain and seed samples: barley, canola, corn, millrun, oats, sorghum, soybean meal and wheat. Issues related to methodology, viability of microbial communities in the gut and feed, and the implications for biosecurity are discussed. | [
"Applied Microbiology and Biotechnology",
"Biophysics"
] | |
Sclerosing Stromal Tumor of the Ovary: US, MR, and Dynamic MR Findings | [
"Radiology, Nuclear Medicine and Imaging"
] | ||
EFFECTS OF INSECT GROWTH REGULATORS ON THE WESTERN SPRUCE BUDWORM (CHORISTONEURA OCCIDENTALIS) (LEPIDOPTERA: TORTRICIDAE): I. LETHAL EFFECTS OF LAST INSTAR TREATMENTS | AbstractDosage–response relationships of seven insect growth regulators (IGRs) to last instar western spruce budworm, Choristoneura occidentalis Freeman, were determined by topical application, spray application, and diet incorporation bioassays. Mortality was defined as failure to emerge as a viable adult. In spray application experiments, four IGRs—ZR-512, ZR-619, ZR-1662, and Ro 10-3108—had LD50s of less than 70 g/ha (1 oz/acre). Relative lethal effectiveness, based on a simple model combining data from the three bioassays, was ZR-1662 > ZR-619 > ZR-512 > Ro 10-3108 > ZR-777 > ZR-587 > ZR-515. We concluded that several IGRs, applied to a population consisting primarily of last instars, would induce lethal effects at dosages comparable to dosages of several conventional insecticides. | The Canadian Entomologist | [
"Insect Science",
"Molecular Biology",
"Physiology",
"Ecology, Evolution, Behavior and Systematics",
"Structural Biology"
] |
Partly Replacing Meat Protein with Soy Protein Alters Insulin Resistance and Blood Lipids in Postmenopausal Women with Abdominal Obesity | [
"Nutrition and Dietetics",
"Medicine (miscellaneous)"
] | ||
Review of what matters? Talking value in Australian culture | Continuum | [
"Visual Arts and Performing Arts",
"Cultural Studies"
] | |
Papillomas of the Larynx with Intraepithelial Anaplastic Changes | Archives of Otolaryngology - Head and Neck Surgery | [
"Otorhinolaryngology",
"Surgery"
] | |
Contents to Volume 15 | [
"Artificial Intelligence",
"Cognitive Neuroscience",
"Experimental and Cognitive Psychology"
] | ||
Equilibrium Adsorption Values of Leuco Vat Dyes on Cotton | [
"Polymers and Plastics"
] | ||
Divisorial contractions to codimension three orbits | Let $G$ be a connected algebraic group. We study $G$-equivariant extremal contractions whose centre is a codimension three $G$-simply connected orbit. In the spirit of an important result by Kawakita in 2001, we prove that those contractions are weighted blow-ups. | Épijournal de Géométrie Algébrique | [
"Geometry and Topology",
"Algebra and Number Theory"
] |
A Personal Tribute | Journal of the American Academy of Child Psychiatry | [
"Psychiatry and Mental Health",
"Pediatrics, Perinatology and Child Health"
] | |
PP-065 EPIDERMOLYSIS BULLOSA IS A REASON OF FATAL HEART FAILURE: CASE REPORT AND REVIEW OF LITERATURE | [
"Cardiology and Cardiovascular Medicine"
] | ||
Subjective sleepiness and daytime functioning in bariatric patients with obstructive sleep apnea | [
"Neurology (clinical)",
"Otorhinolaryngology"
] | ||
Surface-bound Tat inhibits antigen-specific CD8+ T-cell activation in an integrin-dependent manner | [
"Infectious Diseases",
"Immunology",
"Immunology and Allergy"
] | ||
Contra Camera | [
"Library and Information Sciences",
"Philosophy"
] | ||
Immune Response to Vaccination in Patients with Psoriasis Treated with Systemic Therapies | Psoriasis is a chronic inflammatory skin disease usually treated with immunomodulatory/immunosuppressive agents. The use of these agents has been associated with an increased susceptibility to infections. Vaccination might represent a critical aspect in the management of patients with psoriasis treated with immunomodulatory/immunosuppressive therapies. This narrative review aimed to provide an overview on the immune response to vaccines in subjects treated with systemic agents used to treat patients with moderate to severe psoriasis. Publications appearing in PubMed, Scopus, and ISI–Web of Knowledge database were selected using Medical Subject Headings key terms. Overall, published data confirmed that vaccination with attenuated live vaccines during therapy with immunomodulatory/immunosuppressive therapies should be avoided. For nonlive vaccines, a more favorable safety profile of biologic agents compared to conventional systemic agents is described as the humoral response to vaccines is in general well-preserved. Treatment with cyclosporine and methotrexate is associated with lower antibody titers to vaccines, and thus these agents are better discontinued during vaccination. In contrast, treatment with biological agents is not associated with lower antibody response and can thus be continued safely. | [
"Pharmacology (medical)",
"Infectious Diseases",
"Drug Discovery",
"Pharmacology",
"Immunology"
] | |
Photolysis of Rubber | Abstract Rubber hydrocarbon irradiated in vacuo is decomposed by ultraviolet light of wave length less than 4000 A˚. The rubber very rapidly becomes insoluble, and liberates a gaseous mixture which consists mainly of hydrogen when the irradiation temperature is less than 150° C. The reaction characteristics have been investigated, and point to the occurrence of dissociation processes similar to those deduced for comparable simple olefins. When irradiated above 150° C, small but significant amounts of isoprene appear in the volatile product, thereby providing an experimental means of determining the activation energy for the separation of isoprene from a polyisoprene chain terminated by an allyl radical. | Rubber Chemistry and Technology | [
"Materials Chemistry",
"Polymers and Plastics"
] |
Radiation-induced polymerization of acrylamide within Okoume (Aucoumea klaineana pierre) | [
"Radiation"
] | ||
Assessment of Solid Waste from Cruise Ships in the Port of Split | The aim of this paper is to assess the quantity of solid waste in the port of Split produced by cruisers during the past five years. The increased number of cruising guests in the port ofSplit is associated with more marine litter produced and directly increases a potential impact on the marine environment. To sustainably manage its resources, the city of Split should carefully consider the positive and negative effects of the cruising industry, set up a quality control system in cruising and consider how potential profit impacts on the environment and natural resources. | Transactions on Maritime Science | [
"Law",
"Ocean Engineering",
"Transportation",
"Water Science and Technology",
"Automotive Engineering"
] |
Predictable adaptive trajectories of sexual coloration in the wild: Evidence from replicate experimental guppy populations* | Evolution | [
"Genetics",
"Ecology, Evolution, Behavior and Systematics"
] | |
Gravity as the affine goldstone phenomenon and beyond | [
"Nuclear and High Energy Physics",
"Atomic and Molecular Physics, and Optics"
] | ||
Development of Functional Protein Microarrays for Drug Discovery: Progress and Challenges | [
"Organic Chemistry",
"Computer Science Applications",
"Drug Discovery"
] | ||
Epidemiological Trends in Cervical Spine Surgery Between 2002-2009 | The Spine Journal | [
"Neurology (clinical)",
"Surgery",
"Orthopedics and Sports Medicine"
] | |
In search of a happy medium: How the structure of interorganizational networks influence community economic development strategies | Social Networks | [
"Sociology and Political Science",
"Anthropology"
] | |
D-CAST: enhancing communication skills among dental students | [
"Education"
] | ||
Problems | [
"Applied Mathematics",
"Computational Mathematics",
"Computer Networks and Communications",
"Software"
] | ||
Author index of volume 57 | [
"Condensed Matter Physics",
"Mechanics of Materials",
"Metals and Alloys",
"Mechanical Engineering"
] | ||
SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling | Membrane fusion is a universal feature of eukaryotic protein trafficking and is mediated by the soluble N-ethylmaleimide sensitive factor attachment protein receptor (SNARE) family. SNARE proteins embedded in opposing membranes spontaneously assemble to drive membrane fusion and cargo exchange in vitro. Evolution has generated a diverse complement of SNARE regulatory proteins (SRPs) that ensure membrane fusion occurs at the right time and place in vivo. While a core set of SNAREs and SRPs are common to all eukaryotic cells, a specialized set of SRPs within neurons confer additional regulation to synaptic vesicle (SV) fusion. Neuronal communication is characterized by precise spatial and temporal control of SNARE dynamics within presynaptic subdomains specialized for neurotransmitter release. Action potential-elicited Ca2+ influx at these release sites triggers zippering of SNAREs embedded in the SV and plasma membrane to drive bilayer fusion and release of neurotransmitters that activate downstream targets. Here we discuss current models for how SRPs regulate SNARE dynamics and presynaptic output, emphasizing invertebrate genetic findings that advanced our understanding of SRP regulation of SV cycling. | [
"Cellular and Molecular Neuroscience",
"Molecular Biology"
] | |
Everyday Environmentalism: Law, Nature & Individual Behavior | [
"Geography, Planning and Development"
] | ||
What is the Curriculum? | Does it include selling newspapers, building a radio, and going to a dance? And should not the educational program be considered in its entirety? | [
"Education"
] | |
Journal of Fluorescence | [
"Law",
"Clinical Biochemistry",
"Spectroscopy",
"Sociology and Political Science",
"Social Sciences (miscellaneous)",
"Clinical Psychology",
"Biochemistry"
] | ||
Vasculitic Neuropathies | AbstractVasculitic neuropathies are disorders that result from inflammation in the peripheral nerves' vascular supply, resulting in ischemic injury. These disorders may be a result of systemic inflammation or may be confined to the peripheral nervous system. Causative etiologies include primary systemic vasculitis, vasculitis secondary to other conditions such as primary connective tissue disorders, infectious, paraneoplastic, and drug-induced conditions, and nonsystemic vasculitic neuropathy. Early recognition and treatment of these conditions is imperative to prevent substantial morbidity and mortality. The goal of this review is to provide an organization of the vasculitic neuropathies and an overview of principles of diagnosis and treatment for the clinical neurologist. | [
"Neurology (clinical)",
"Neurology"
] | |
Size and Distribution of Rhodolith Beds in the Loreto Marine Park: Their Role in Coastal Processes | [
"Earth-Surface Processes",
"Water Science and Technology",
"Ecology"
] | ||
Proxy measures of cognitive reserve and trajectories of gait and cognitive decline in older adults | [
"Psychiatry and Mental Health",
"Cellular and Molecular Neuroscience",
"Geriatrics and Gerontology",
"Neurology (clinical)",
"Developmental Neuroscience",
"Health Policy",
"Epidemiology"
] | ||
Enhanced production of pituitary adenylate-cyclase-activating polypeptide by 1, N6-dibutyryladenosine 3',5'-monophosphate, phorbol 12-myristate 13-acetate and by the polypeptide itself in human neuroblastoma cells, IMR-32 | [
"Biochemistry"
] | ||
The Selection of the Phosphorus Index in Papaya Tissue Analysis1 | Abstract A phosphorus fertilizer experiment at Puna, Hawaii comprising 3 application rates was conducted over a period of 11/2 years in “aa” lava soil on fruiting papaya trees (Carica papaya L. ‘Solo’). Leaves at 3 stages of maturity were sampled 4 times a year, and the dried ground leaves were chemically analyzed for P. The weight of fruits was obtained at weekly intervals. A curvilinear regression of yield on concentration of P was determined for each leaf tissue at each stage, at each sampling date. A multiple correlation coefficient was then obtained from each of these calculations. In general, the highest multiple correlation coefficients were obtained with the “recently matured” petiole. Thus, the concentration of P in this tissue on a dry weight basis was selected as the P index of papaya. The critical levels which related yield to the P index and the weights of leaves to the P index were determined for April and May and were found to be about the same. They were 0.25% P for the maximum yield or weight of leaves and 0.213% P for 5% off the maximum. These levels can serve tentatively as a basis for P fertilization of papaya in the Puna area of Hawaii. | [
"Horticulture",
"Genetics"
] | |
Quasiparticle-Core-Coupling in191Pt Using Dynamic Deformation Theory Core Wave Functions | Physica Scripta | [
"Condensed Matter Physics",
"Mathematical Physics",
"Atomic and Molecular Physics, and Optics"
] | |
2. Grundwissenschaften | [
"Materials Chemistry",
"Colloid and Surface Chemistry",
"Polymers and Plastics",
"Physical and Theoretical Chemistry"
] | ||
¿Es útil el SPPB como método de screening de capacidad funcional en pacientes con enfermedad renal crónica avanzada? | [
"Nephrology"
] | ||
Macrophage and CSF-1 Dependent Renal Repair Following Ischemia and Reperfusion | [
"Transplantation"
] | ||
Effect of thermal aging and electrolyte on bentonite dispersions: Rheology and morphological properties | [
"Materials Chemistry",
"Physical and Theoretical Chemistry",
"Spectroscopy",
"Condensed Matter Physics",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
ANALYSIS OF PARALINGUISMS INVOLVING HEAD ORGANS | This article sheds light on the role of the head and its parts in the formation of paralinguistic tools with the help of texts from Uzbek works. Also, the actions that create the most active paralinguisms among the head members and are widely used among the Uzbek people are based on diagrams and tables. | Journal of Pharmaceutical Negative Results | [
"Drug Discovery",
"Pharmaceutical Science",
"Pharmacology"
] |
The Development and Evolution of Two Atmospheric Rivers in Proximity to Western North Pacific Tropical Cyclones in October 2010 | Abstract This study investigates the evolution of two zonally elongated atmospheric rivers (ARs) that produced >200 mm of rainfall over mountainous regions of Northern California in late October 2010. Synoptic-scale analysis and air parcel trajectory analysis indicate that the ARs developed within high-CAPE environments characterized by troposphere-deep ascent as water vapor was transported directly from western North Pacific tropical cyclones (TCs) toward the equatorward entrance region of an intensifying North Pacific jet stream (NPJ). The same ARs were subsequently maintained as water vapor was transported from extratropical and subtropical regions over the central and eastern North Pacific in an environment characterized by quasigeostrophic forcing for ascent and strong frontogenesis along the anticyclonic shear side of an intense and zonally extended NPJ. Although the ARs developed in conjunction with water vapor transported from regions near TCs and in the presence of troposphere-deep ascent, an atmospheric water vapor budget illustrates that decreases in integrated water vapor (IWV) via precipitation are largely offset by the horizontal aggregation of water vapor along the AR corridors via IWV flux convergence in the presence of frontogenesis. The frameworks used for investigations of predecessor rain events ahead of TCs and of interactions between recurving TCs and the NPJ are also utilized to illustrate many dynamically similar processes related to AR development and evolution. Similarities include the following: water vapor transport directly from a TC, troposphere-deep ascent in a high-CAPE environment beneath the equatorward entrance region of an intensifying upper-tropospheric jet streak, interactions between diabatic outflow and an upper-tropospheric jet streak, and strong frontogenesis. | [
"Atmospheric Science"
] | |
Like Lions They Fought: The Zulu War and the Last Black Empire in South Africa. | The American Historical Review | [
"Museology",
"Archeology",
"History"
] | |
Polyp follow-up: How, who for and how often? | [
"Surgery"
] | ||
More on patterns in Mie scattering | [
"Electrical and Electronic Engineering",
"Physical and Theoretical Chemistry",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
“None’s Reflex”: Enactivism and Observational Philosophy on Consciousness and Observation | The paper is dedicated to the reconstruction of Alexander Piatigorsky’s observational philosophy within the context of the confrontation between two versions of the transcendental project of man-in-the-world. The first project accentuates the invariant functional organization of cognitive systems by abstracting from bodily, affective and phenomenological realization of this organization. On the contrary, the second project emphasizes the phenomenological perspective of the experience of givenness, always already dependent on whose experience this is and how the cognitive system living this experience is organized. The first project can be called functionalist, and the second – phenomenological. Ontological and epistemological positions of these projects are specified in the problem of the observer, its status in the world and cognitive practice. The observational philosophy possesses an intermediate position between these two programs since, aiming to disclose the invariant structure of observation, it proceeds from the factual experience of the embodied subject placed into the situation of self-observation and observation of the other subject. It is concluded that Piatigorsky’s philosophy borrows from the functionalist project the commitment to self-objectivation (observation of thinking is always the observation of the other thinking) and rejection from the spatiotemporal localization of cognitive activity (thinking is always “none’s” and does not belong to any kind of individual). With the phenomenological project of enactivism Piatigorsky shares the aspiration to disclose the invariant cognitive structures during the empirical observation of the real enactment of cognitive agency (the organization of cognitive systems is the same while its structural realizations are multiple), abandonment of substantialization of the self (“none’s” thinking is considered as the emergent effect of interaction among two or several observers – the autopoietic systems) as well as the refusal from theoretical formulation of the problem of consciousness (observational philosophy develops metatheoretical prolegomena to theory of consciousness, which in turn is considered as lived and essentially practical in phenomenology). | Russian Journal of Philosophical Sciences | [
"Pharmacology (medical)",
"Complementary and Alternative Medicine",
"Pharmaceutical Science"
] |
Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults | [
"Anesthesiology and Pain Medicine"
] | ||
Excitation of low-frequency seismic body waves in an underground explosion | [
"Mechanical Engineering",
"Mechanics of Materials",
"Condensed Matter Physics"
] | ||
Why was early therapeutic research on psychedelic drugs abandoned? | AbstractBackgroundAdvocates of the therapeutic use of psychedelic drugs have argued that a promising approach to treatment was prematurely abandoned in the 1960s primarily because of Richard Nixon's ‘War on Drugs’.This paper (1) briefly describes research in the 1950s and 1960s in North America on the use of LSD to treat alcohol dependence, anxiety in terminal illness, and anxiety and depression; and (2) discusses the factors that led to its abandonment.MethodAn analysis of historical scholarship on psychedelic research in the 1950s, 1960s and 1970s in North America.ResultsResearch on psychedelic drugs in psychiatry was abandoned for a number of reasons that acted in concert. A major factor was that clinical research on psychedelic drugs was caught up in the tighter regulation of pharmaceutical research after the Thalidomide disaster in 1963. Psychedelic drugs also presented special challenges for randomised, placebo-controlled clinical trials in the 1970s that were not as positive as the claims made by their advocates in the 1950s and 1960s. Clinical research became more difficult after 1965 when Sandoz ceased providing psychedelic drugs for research and their nonmedical use was prohibited in 1970.ConclusionsThe demise of psychedelic drug research was not solely due to the ‘War on Drugs’. It was hastened by tighter regulation of pharmaceutical research, the failure of controlled clinical trials to live up to the claims of psychedelic advocates, and the pharmaceutical industry's lack of interest in funding clinical trials. | Psychological Medicine | [
"Psychiatry and Mental Health",
"Applied Psychology"
] |
Inhibition of collagenase by aranciamycin and aranciamycin derivatives. | Journal of Medicinal Chemistry | [
"Drug Discovery",
"Molecular Medicine"
] | |
Nuclear Excitation by Positron Annihilation | [
"Nuclear and High Energy Physics"
] | ||
Allozyme Comparison and Infectivity of Cultured Stages of Trypanosoma fallisi from Southern Ontario and a Trypanosome of Toads from Northern Michigan | The Journal of Parasitology | [
"Ecology, Evolution, Behavior and Systematics",
"Parasitology"
] | |
Self-monitoring: Methodological limitations and clinical applications. | [
"Psychiatry and Mental Health",
"Clinical Psychology"
] | ||
How We Learn to Read. Seymour W. Itzkoff | [
"Education"
] | ||
Erstmanifestation eines Morbus Crohn in der Spätschwangerschaft: Indikation zur Ileozäkalresektion mit nachfolgendem Spontanpartus | [
"Maternity and Midwifery",
"Obstetrics and Gynecology"
] | ||
Postpartum contraception utilization among low-income women seeking immunization for infants in Mumbai, India | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | ||
Circadian Activation of Bullfrog Retinal Mitogen-activated Protein Kinase Associates with Oscillator Function | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | ||
Research on the Logical Evolution of Internationalization Strategy of Chinese Construction Enterprises Based on the Concept of Project Sharing | [
"Political Science and International Relations",
"Sociology and Political Science"
] | ||
Perspectives of People Who Are Deaf and Hard of Hearing on Mental Health, Recovery, and Peer Support | [
"Psychiatry and Mental Health",
"Public Health, Environmental and Occupational Health",
"Health (social science)"
] | ||
Experimental Investigation on Axial Compression of Resilient Nail-Cross-Laminated Timber Panels | Conventional cross-laminated timber is an engineered wood product consisting of solid-sawn lumber panels glued together. In this study, the structural behavior of solid wood panels of Nail-Cross-Laminated Timber (NCLT) panels connected with nails instead of glue was studied. The failure mode and nail deformation of the novel NCLT panels under axial compression load using eight full-scale NCLT panels was investigated. The effects of four key design parameters, namely, the nail type, number of nails, nail orientation angle, and nail slenderness ratio on axial compression performance of NCLT panels were also analyzed. In addition, a formula for predicting the axial compression bearing capacity of NCLT panels was developed. For calculation of the slenderness ratio, the moment of inertia of the full section or the effective section was determined based on the nail type, number of nails, angle of nail orientation and number of layers of the plate. Results showed that specimens connected by tapping screws had best compressive performance. | Sustainability | [
"Management, Monitoring, Policy and Law",
"Renewable Energy, Sustainability and the Environment",
"Geography, Planning and Development"
] |
The benefits of an infectious disease/radiology multidisciplinary team meeting | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
Comparison of forced ENSO-like hydrological expressions in simulations of the preindustrial and mid-Holocene | [
"Space and Planetary Science",
"Earth and Planetary Sciences (miscellaneous)",
"Atmospheric Science",
"Geophysics"
] | ||
Psychiatrie: Klinik der Erkankung des Vorderhirns | [
"Psychiatry and Mental Health"
] | ||
Structure of an acidic polysaccharide from the marine bacterium Pseudoalteromonas flavipulchra NCIMB 2033T | [
"Organic Chemistry",
"Biochemistry",
"Analytical Chemistry"
] | ||
Subtle intracorneal findings in inflammatory disorders: hyphae or not? | Journal of Cutaneous Pathology | [
"Dermatology",
"Histology",
"Pathology and Forensic Medicine"
] | |
Correlation and Predictive Relationship between Self-determination Instruction and Academic Performance of Students with Disabilities | [
"Education"
] |
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