Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
Placing pain on the sensory map: Classic papers by Ed Perl and colleagues | This essay looks at two papers published by Ed Perl and co-workers that identified specifically nociceptive neurons in the periphery and superficial dorsal horn. Bessou P and Perl ER. Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J Neurophysiol 32: 1025–1043 1969. Christensen BN and Perl ER. Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn. J Neurophysiol 33: 293–307 1970. | Journal of Neurophysiology | [
"Physiology"
] |
Surgical Management of Degenerative Scoliosis | [
"Orthopedics and Sports Medicine",
"Surgery"
] | ||
De-awning of Agropyron spicatum cultivator for use as an understory grass on erosive sites | South-facing, semi-arid slopes supporting sagebush (Artemisia tridentata) with scant understory are difficult sites for establishment of perennial vegetative cover in Central Washington. Blue-bunch wheatgrass (Agropyron spicatum) is the most ubiquitous, widely distributed native perennial where exotic annuals are a competitive problem. It can be found as an understory associate or in open stands.Secar is a cultivar, of A. spicatum developed in the Pacific Northwest. Unfortunately, the percent germination of secar seed has been found to be low. It was suspected that a possible inhibitor exists in the awn and mechanical removal may result in earlier and greater germinative ability for increased establishment on Conservation Reserve Program lands.It was found that total germination was not significantly affected by temperature treatment but an apparent difference in rate was determined. A significant increase in germination occurred with awn removal. Specific location of an inhibitor(s) was not statistically apparent. Key words: Agropyron spicatum, germination, seedling vigor, reseeding | [
"Forestry"
] | |
IEEE Photonics Technology Letters information for authors | [
"Electrical and Electronic Engineering",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
J-Shaped Association Between QTc Interval Duration and the Risk of Atrial Fibrillation | [
"Cardiology and Cardiovascular Medicine"
] | ||
Hypothermisierende psychotrope Pharmaka als Strahlenschutzstoffe Hypothermia producing psychotropic drugs as radioprotective agents | [
"Aquatic Science",
"Oceanography"
] | ||
fshr and lhr mRNA expression in granulosa cells of poor responder | Abstract In Vitro Fertilization (IVF) is one of the most commonly used procedures to help pregnancies in couples who have infertility problems. One of the problems of infertility is poor ovarian response and the woman who experiences it is known as poor responder. Poor responders do not have an adequate ovarian response to gonadotropin in ovarian stimulation. The success of fertilization in poor responders tends to be low due to low quantity and is generally followed by low oocyte quality. Gonadotropins consisting of FSH and LH, play a role in follicle development and ovulation. The follicle response in capturing gonadotropins depends on the exact bond between the hormone and its receptor (FSHR and LHR) in the granulosa cells surrounding the oocyte. The purpose of this research is to know the expression level of fshr and lhr mRNA in granulosa cells of poor responders through real-time PCR method which then tested statistically using t-test. Fourteen samples of each poor responders and normal women were used in this research. The results showed insignificant differences between expression level of fshr and lhr mRNA in granulosa cells of poor responders and normal women (p > 0.05). | [
"Computer Science Applications",
"History",
"Education"
] | |
Spectroscopic studies of Eu3+ ions in LBTAF glasses | [
"Materials Chemistry",
"Metals and Alloys",
"Mechanical Engineering",
"Mechanics of Materials"
] | ||
Lockdown and adolescent mental health: reflections from a child and adolescent psychotherapist | The author, a child and adolescent psychoanalytic psychotherapist working in the UK NHS, discusses the varied impacts of ‘lockdown’ on adolescents, their parents and the psychotherapists who work with them, during the COVID-19 pandemic, in this short observational paper that contributes to the Waiting in Pandemic Times Wellcome Collection in response to COVID-19. She asks, particularly, how psychological therapies are positioned during such a crisis, and whether the pressures of triage and emergency can leave time and space for sustained emotional and psychological care. She wonders how psychoanalytic time with its containing rhythm can be held onto in the face of the need for triage on the one hand and the flight to online and telephone delivery on the other. Above all, the author questions how the apparent suspension of time during lockdown is belied by the onward pressure of adolescent time, and how this can be understood by, and alongside, troubled adolescents. | [
"Medicine (miscellaneous)"
] | |
Un sénateur de Xanthos | Journal des savants | [
"Literature and Literary Theory"
] | |
Graphene Oxide–Platinum Nanoparticle Nanocomposites: A Suitable Biocompatible Therapeutic Agent for Prostate Cancer | Metal nanoparticles and the combination of metal nanoparticles with graphene oxide are widely used in environmental, agriculture, textile, and therapeutic applications. The effect of graphene oxide–green platinum nanoparticles (GO-PtNPs) on human prostate cancer cells (LNCaP) is unclear. Therefore, this study aimed to synthesize a nanocomposite of GO-PtNPs and evaluate their effect on prostate cancer cells. Herein, we synthesized GO-PtNPs using vanillin and characterized GO-PtNPs. GO-PtNP cytotoxicity in LNCaP cells was demonstrated by measuring cell viability and proliferation. Both decreased in a dose-dependent manner compared to that by GO or PtNPs alone. GO-PtNP cytotoxicity was confirmed by increased lactate dehydrogenase release and membrane integrity loss. Oxidative stress induced by GO-PtNPs increased malondialdehyde, nitric oxide, and protein carbonyl contents. The effective reactive oxygen species generation impaired the cellular redox balance and eventually impaired mitochondria by decreasing the membrane potential and ATP level. The cytotoxicity to LNCaP cells was correlated with increased expression of proapoptotic genes (p53, p21, Bax, Bak, caspase 9, and caspase 3) and decreased levels of antiapoptotic genes (Bcl2 and Bcl-xl). Activation of the key regulators p53 and p21 inhibited the cyclin-dependent kinases Cdk2 and Cdk4, suggesting that p53 and p21 activation in GO-PtNP-treated cells caused genotoxic stress and apoptosis. The increased expression of genes involved in cell cycle arrest and DNA damage and repair, and increased levels of 8-oxo-deoxyguanosine and 8-oxoguanine suggested that GO-PtNPs potentially induce oxidative damage to DNA. Thus, GO-PtNPs are both cytotoxic and genotoxic. LNCaP cells appear to be more susceptible to GO-PtNPs than to GO or PtNPs. Therefore, GO-PtNPs have potential as an alternate and effective cancer therapeutic agent. Finally, this work shows that the combination of graphene oxide with platinum nanoparticles opens new perspectives in cancer therapy. However further detailed mechanistic studies are required to elucidate the molecular mechanism of GO-PtNPs induced cytotoxicity in prostate cancer. | [
"Polymers and Plastics"
] | |
Survival of Corynebacterium Michiganense Subsp. Michiganense Within Host Debris in Soil. | [
"Plant Science"
] | ||
The random walk description for isotope exchange in a polypeptide | [
"Organic Chemistry",
"Biochemistry",
"Biophysics"
] | ||
Excitation of pulsations in the CNO ionization zone of luminous stars | The Astrophysical Journal | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | |
Machine learning for tissue diagnostics in oncology: brave new world | [
"Cancer Research",
"Oncology"
] | ||
The diet and vegetation composition of Egyptian tortoise habitat in North Sinai, Egypt | Abstract We studied the diet and vegetation composition of Egyptian tortoise, Testudo kleinmanni, habitat in North Sinai, Egypt. Dietary data was recorded through direct observations and the vegetation composition was recorded through the use of quadrats and line transects in 66 sampling points (33 in tortoise areas and 33 in non-tortoise areas). Our results showed that vegetation of Egyptian tortoise habitat had high species richness, Simpson’s diversity index, and vegetation cover in contrast to areas without Egyptian tortoises. These tortoises ate thirty four species of plants, a majority of these being perennials, with most feeding observations occurring in spring and winter. The consumption of perennials may enable Egyptian tortoises to find and consume food in an arid environment with low, variable and unpredictable rainfall. The plants most consumed were rare in our vegetation survey, suggesting food preferences. Our study suggests that Egyptian tortoises, which rely on vegetation for food and refugia, may suffer if vegetation cover and richness decrease. | [
"Animal Science and Zoology",
"Ecology, Evolution, Behavior and Systematics"
] | |
The enzyme histochemistry of developing brown fat in the fetal rat | Histochemie | [
"Cell Biology",
"Medical Laboratory Technology",
"Molecular Biology",
"Histology"
] | |
Degradation mechanism of p-cresol in aqueous solutions by gamma-ray irradiation | [
"Health, Toxicology and Mutagenesis",
"Public Health, Environmental and Occupational Health",
"Spectroscopy",
"Pollution",
"Radiology, Nuclear Medicine and Imaging",
"Nuclear Energy and Engineering",
"Analytical Chemistry"
] | ||
Night shift hormone: How does melatonin affect depression? | Physiology & Behavior | [
"Behavioral Neuroscience",
"Experimental and Cognitive Psychology"
] | |
Upcoming Meetings/Réunions à venir | [
"Forestry"
] | ||
Researchers Interview and Study Chronically Homeless Older Men | [
"Psychiatric Mental Health"
] | ||
Objective Index of Haemodynamic Status for Quantitation of Severity and Prognosis of Shock Complicating Myocardial Infarction | Cardiovascular Research | [
"Physiology (medical)",
"Cardiology and Cardiovascular Medicine",
"Physiology"
] | |
Inhibition of Prodigiosin Formation in Serratia marcescens by Extracts of Toxic Cyanobacteria | [
"Applied Microbiology and Biotechnology",
"Ecology, Evolution, Behavior and Systematics",
"Microbiology"
] | ||
Sporulation und spezifische Sporangium-Reaktion | [
"Cell Biology",
"Molecular Biology",
"Pathology and Forensic Medicine"
] | ||
Suicide and Mortuary Beliefs and Practices of the Akan of Ghana | Akan society has traditionally held a negative and condemnatory view of suicide. Evidence of this is reflected in the lack of public mourning, brevity of the grieving period, and denial of proper burial rites and funeral obsequies for the suicide. Furthermore, because suicide is regarded as an abomination against the living, the departed ancestors, as well as the gods of the land, the political authorities of the land must be notified immediately of suicide deaths so that proper placatory and propitiation rituals can be undertaken to forestall any catastrophic diseases, accidents, and natural disasters. Given the current paucity of scholarship on the issue, it is the purpose of this article to explore in depth traditional Akan mortuary beliefs and practices governing suicidal death. | OMEGA - Journal of Death and Dying | [
"Life-span and Life-course Studies",
"Critical Care and Intensive Care Medicine",
"Health (social science)"
] |
Moving Electric Transportation Forward: The Many Faces of Electric Vehicles | World Electric Vehicle Journal | [
"Automotive Engineering"
] | |
The causes and treatment of uterine bleeding | [
"Surgery"
] | ||
Formal Specification of the NoSQL Document-Oriented Data Model | [
"Industrial and Manufacturing Engineering",
"Polymers and Plastics",
"Business and International Management"
] | ||
Structural and Optical-Phonon Properties of InSb Nanocrystals Synthesized in Si and SiO2 Matrices | Semiconductors | [
"Condensed Matter Physics",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | |
FROM THE EDITOR | [
"Information Systems and Management",
"Computer Science Applications",
"Software"
] | ||
Annexin II represents metastatic potential in clear-cell renal cell carcinoma | [
"Cancer Research",
"Oncology"
] | ||
Extended maintenance intervals during long-term venom immunotherapy (VIT) | [
"Immunology",
"Immunology and Allergy"
] | ||
Species Identification and Strain Differentiation of Dermatophyte Fungi by Analysis of Ribosomal-DNA Intergenic Spacer Regions | ABSTRACT Restriction fragment length polymorphisms (RFLPs) identified in the ribosomal-DNA (rDNA) repeat were used for molecular strain differentiation of the dermatophyte fungus Trichophyton rubrum . The polymorphisms were detected by hybridization of Eco RI-digested T. rubrum genomic DNAs with a probe amplified from the small-subunit (18S) rDNA and adjacent internal transcribed spacer (ITS) regions. The rDNA RFLPs mapped to the nontranscribed spacer (NTS) region of the rDNA repeat and appeared similar to those caused by short repetitive sequences in the intergenic spacers of other fungi. Fourteen individual RFLP patterns (DNA types A to N) were recognized among 50 random clinical isolates of T. rubrum . A majority of strains (19 of 50 [38%]) were characterized by one RFLP pattern (DNA type A), and four types (DNA types A to D) accounted for 78% (39 of 50) of all strains. The remaining types (DNA types E to N) were represented by one or two isolates only. A rapid and simple method was also developed for molecular species identification of dermatophyte fungi. The contiguous ITS and 5.8S rDNA regions were amplified from 17 common dermatophyte species by using the universal primers ITS 1 and ITS 4. Digestion of the amplified ITS products with the restriction endonuclease Mva I produced unique and easily identifiable fragment patterns for a majority of species. However, some closely related taxon pairs, such as T. rubrum-T. soudanense and T. quinkeanum-T. schoenlenii could not be distinguished. We conclude that RFLP analysis of the NTS and ITS intergenic regions of the rDNA repeat is a valuable technique both for molecular strain differentiation of T. rubrum and for species identification of common dermatophyte fungi. | [
"Microbiology (medical)"
] | |
Profiles of Recruits Entering Army Basic Training in New Zealand | ABSTRACT Introduction A high incidence of musculoskeletal injuries is sustained by army recruits during basic training. Describing recruits’ personal, lifestyle, and physical performance characteristics at the entry to training can help identify existing intrinsic risk factors that may predispose some recruits to injury. Identifying modifiable and preventable intrinsic risk factors may contribute to lower recruit injury and associated burdens during the course of basic training. The aim of this study was to therefore describe the profile of New Zealand Army recruits upon entry to basic training using personal, lifestyle, and physical performance characteristics. Methods New Zealand Army male and female recruits from two intakes in the same year were invited to participate. Recruits’ data on personal (sex, age, height, and weight), lifestyle (self-reported responses to the Military Pre-training Questionnaire comprising physical and injury history, diet, alcohol, and smoking status) and physical performance characteristics (2.4-km timed run, weight-bearing dorsiflexion lunge test, and the Y Balance TestTM for lower limb dynamic stability) were collected and analyzed. Results Participants included 248 New Zealand Army recruits: 228 males (91.9%), 20 females (8.1%), average age of 20.3 ± 2.8 years. Findings indicated 30.9% of recruits reported injury in the 12 months prior to training commencing, with 44.8% of those injuries in the lower limbs. Pre-entry alcohol consumption was higher than recommended and 20.1% of recruits identified as current smokers. Recruits who passed the 2.4-km timed run included 53.8% of males and 28.6% of females. Weight-bearing dorsiflexion lunge test performance was within a normal range (right = 10.3 ± 3.3 cm), however limb asymmetry (>1.5 cm) was present with 30.9% of recruits. For the Y Balance TestTM for dynamic lower limb stability, 70% of female recruits had high posterolateral reach asymmetry (8.1 ± 6.0 cm), while normalized composite reach scores were low (right) for male (92.2 ± 8.1%) and female recruits (89.0 ± 7.5%). Conclusions New Zealand Army recruits entering basic training were predominantly active young males, reported few injuries in the previous year, had higher than recommended alcohol consumption and a minority were smokers. The majority of recruits had low aerobic fitness, average ankle dorsiflexion range, and low dynamic lower limb stability. While a number of adverse characteristics identified are potentially modifiable, more research is required to identify an association to musculoskeletal injury risk in New Zealand Army recruits. Describing the profile of recruits entering training, particularly recruits at risk of injury is one of the first steps in injury prevention. | [
"Public Health, Environmental and Occupational Health"
] | |
Assessing fetal movements in pregnancy: A qualitative evidence synthesis of women’s views, perspectives and experiences | Abstract Background Raising awareness of the importance of fetal movements (FMs) and advising women on the appropriate action to take if they experience reduced FMs, is important for minimising or avoiding adverse perinatal outcomes. To gain insight and understanding of women’s perspectives of assessing FMs in pregnancy, we conducted a qualitative evidence synthesis. Methods A qualitative evidence synthesis using thematic synthesis was conducted. Studies were eligible if they included pregnant women who were at least 20 weeks gestation and reported qualitative data from women on assessing FMs in pregnancy. MEDLINE, CINAHL, EMBASE, PsycINFO and Social Science Citation Index, from inception to July 2020, were searched. The methodological quality of included studies was assessed by at least two reviewers using an Evidence for Policy and Practice Information (EPPI)-Centre quality assessment tool. Data synthesis, using the Thomas and Harden framework, involved line by line coding of extracted data, establishing descriptive themes, and determining analytical themes. Confidence in the findings was assessed using GRADE CER-Qual. Results Nine studies, involving 2193 women, were included in the review. The methodological quality of the studies was overall generally high. The synthesis revealed three dominant themes, and seven sub-themes that reflected women’s perspectives of assessing FMs in pregnancy. These were; 1) How women engage with FMs, with subthemes of informal engagement, formal engagement, and strategies to stimulate FMs; 2) ‘ … like a feather inside my belly’ - articulating and describing FMs, with sub-themes of sensations associated with FMs and timing and frequency of FMs; and 3) FMs and help/health seeking, with sub-themes of information sources and interacting with healthcare professionals. Confidence in the findings was either high or moderate, although two findings were rated low confidence and one very low. Conclusion This qualitative evidence synthesis reveals that women informally engage with FMs during pregnancy. Women commonly adopt strategies to stimulate FMs when concerned. The use of the internet was a common source of obtaining information regarding FMs. Women require better support when contacting healthcare professionals about FMs. As only three of the nine included studies were exclusively qualitative in design, further qualitative studies exploring women’s perspective of assessing FMs in pregnancy are required. | [
"Obstetrics and Gynecology"
] | |
Letter to the editor | [
"Surgery"
] | ||
On the cytotoxicity of some microbial volatile organic compounds as studied in the human lung cell line A549 | Chemosphere | [
"Environmental Chemistry",
"Environmental Engineering",
"Pollution",
"Health, Toxicology and Mutagenesis",
"Public Health, Environmental and Occupational Health"
] | |
Establishing pathological cut-offs for lateral ventricular volume expansion rates | [
"Cognitive Neuroscience",
"Neurology (clinical)",
"Neurology",
"Radiology, Nuclear Medicine and Imaging"
] | ||
Measuring batting parameters in cricket: A two-stage regression-OWA method | [
"Applied Mathematics",
"Electrical and Electronic Engineering",
"Condensed Matter Physics",
"Instrumentation"
] | ||
About the presence of Eemian peats in the Geneva basin and its implications: a reply to comments by Preusser et al. | [
"Geology",
"Archeology",
"Ecology, Evolution, Behavior and Systematics",
"Global and Planetary Change"
] | ||
Stewart Shapiro and Geoffrey Hellman, eds. The History of Continua: Philosophical and Mathematical Perspectives | [
"Philosophy"
] | ||
Involvement of syncytin glycoprotein in human trophoblast cell differentiation and endocrine activity | [
"Endocrinology",
"Endocrinology, Diabetes and Metabolism",
"Internal Medicine"
] | ||
Blocking bug - complete atrioventricular block in chronic Chagas disease | [
"Cardiology and Cardiovascular Medicine"
] | ||
Eggshell crack detection by dynamic frequency analysis | [
"Industrial and Manufacturing Engineering",
"Biochemistry",
"Food Science",
"Biotechnology"
] | ||
Synthesis and crystal structure of a dinuclear yttrium(III)- (lanthanide(III)-) copper(II) complex with an unusual 2-methyl-2,4,6-tris(trifluoromethyl)-1,3-dioxane-4,6-diolato ligand | Inorganic Chemistry | [
"Inorganic Chemistry",
"Physical and Theoretical Chemistry"
] | |
A Case Report on the Effect of Sham Acupuncture | [
"Anesthesiology and Pain Medicine",
"Complementary and Alternative Medicine"
] | ||
Análise da sensibilidade ao contraste em militares aeronavegantes: Estudo exploratório / Analysis of contrast sensitivity in military aircrew: Exploratory study | A visão é considerada o sentido mais importante para obter informações e referências durante o voo, sendo responsável por cerca de 80% da orientação no ambiente de aviação. A acuidade visual (AV) é a função visual mais importante testada nos aeronavegantes (indivíduos cuja função laboral se desenvolve dentro de uma aeronave). A sensibilidade ao contraste (SC) é outra importante função visual, definida como a capacidade de discernir uma imagem entre luminâncias de diferentes níveis. Os testes de SC propiciam uma melhor descrição das propriedades resolutivas do sistema visual em relação às obtidas apenas com a medida da AV. Por esta razão este estudo objetivou caracterizar a SC em uma amostra de militares aeronavegantes e compará-la com os resultados de um grupo controle (militares não aeronavegantes). Para tal, foram constituídos dois grupos, pelo critério de acessibilidade, a saber: aeronavegantes (AE; n=58; 34,5 ± 5,77 anos) e grupo controle (GC; n=28; 35,14 ± 7,2 anos), todos do serviço ativo e do sexo masculino, totalizando 172 olhos. Os dados foram coletados no momento da inspeção de saúde dos militares. Primeiramente, foi realizado o exame oftalmológico conforme as instruções técnicas em vigor e, na sequência, o teste de SC, utilizando a Tabela de Pelli-Robson. Além disso, foi preenchido um questionário para obtenção de informações pessoais. Foi realizada a estatística descritiva, a distribuição de frequências e a relação entre variáveis qualitativas (teste qui-quadrado), considerando p ≤ 0,05. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa do Hospital de Força Aérea do Galeão (Número de Registro 3.476.886). A SC média encontrada no grupo de AE foi de 1,71 log SC em olho direito (OD); 1,71 log SC em olho esquerdo (OE) e 1,97 log SC em ambos os olhos (AO). A SC média encontrada no GC foi de 1,69 log SC em OD; 1,66 log SC em OE e 1,96 log SC em AO. Houve diferença estatisticamente significativa entre os grupos para a SC do OE. A SC do grupo AE foi, em média, maior que a do GC. Os valores de referência da Tabela de Pelli-Robson encontrados na literatura para a faixa etária estudada foram de 1,80 log SC e 1,95 log SC para medidas monoculares e binoculares, respectivamente. Em ambos os grupos, a média dos resultados da SC monocular ficou ligeiramente abaixo do valor de referência e a da SC binocular ficou acima desse valor. Para fins periciais, a inclusão do teste de SC proporcionaria um exame oftalmológico mais completo, permitindo a detecção mais precoce de determinadas patologias oculares e de possíveis alterações na SC relacionadas à realização de cirurgia refrativa. A avaliação dessa função visual possibilitaria também reconhecer aspectos relativos à performance visual, contribuindo para a otimização do desempenho humano operacional. Sugere-se estudos posteriores a fim de verificar e categorizar a SC em quadros/especialidades específicas para militares. | Brazilian Journal of Development | [
"Marketing",
"Organizational Behavior and Human Resource Management",
"Strategy and Management",
"Drug Discovery",
"Pharmaceutical Science",
"Pharmacology"
] |
Preliminary reconstructions of spring precipitation in southwestern Turkey from tree-ring width | [
"Atmospheric Science"
] | ||
Studies on the Chemistry of Cedrus libani A. Rich. - III. Oleoresin Composition of Cones and Bark from Cedrus libani | [
"Biomaterials"
] | ||
Torsional power study using CENTURION phacoemulsification technology | Clinical & Experimental Ophthalmology | [
"Ophthalmology"
] | |
Surveying Mechanisms of Immune Checkpoint Blockade from a VISTA | Abstract Defining the mechanisms of action of immune checkpoint blockade therapies is essential for effectively designing combination therapeutic approaches and developing the next generation of immunotherapies. In this issue, Schaafsma and colleagues report that V-domain immunoglobulin suppressor of T-cell activation antagonism acts through mechanisms distinct from anti–CTLA-4 and anti—programmed cell death protein 1 via remodeling of the myeloid-cell compartment and modulating T-cell quiescence. See related article by Schaafsma et al. p. 38 (1). | [
"Cancer Research",
"Immunology"
] | |
A framework for joint resource allocation of MapReduce and web service applications in a shared cloud cluster | [
"Artificial Intelligence",
"Computer Networks and Communications",
"Hardware and Architecture",
"Theoretical Computer Science",
"Software"
] | ||
Intramolecular Pnicogen Interactions in PHF(CH2)nPHF (n=2-6) Systems | [
"Physical and Theoretical Chemistry",
"Atomic and Molecular Physics, and Optics"
] | ||
Development of three-dimensional GPU DEM code–benchmarking, validation, and application in mineral processing | [
"Computational Mathematics",
"Fluid Flow and Transfer Processes",
"Modeling and Simulation",
"Numerical Analysis",
"Civil and Structural Engineering",
"Computational Mechanics"
] | ||
Comptes rendus | [
"Literature and Literary Theory",
"Linguistics and Language",
"Religious Studies",
"History",
"Language and Linguistics"
] | ||
Moth sex-pheromone biosynthesis is inhibited by the herbicide diclofop | Pesticide Biochemistry and Physiology | [
"Health, Toxicology and Mutagenesis",
"Agronomy and Crop Science"
] | |
Proteomic signatures differentiatingBacillus anthracisSterne sporulation on soil relative to laboratory media | Influence of environment on proteomic signatures ofB. anthracissporulation related to specific factors. | The Analyst | [
"Electrochemistry",
"Spectroscopy",
"Environmental Chemistry",
"Biochemistry",
"Analytical Chemistry"
] |
Hormone manipulation to overcome a major barrier in male catfish spawning: The role of oxytocin augmentation in inducing voluntary captive spawning | [
"Aquatic Science"
] | ||
Editorial | It is with great pleasure that we announce the resumption of the peer journal “Laser Therapy” publications after two years of silence. In fact, due to the terrible pandemic that has devastated our world, has taken away friends and family members and has deeply changed our lifestyles, the latest issue was published online in the Spring of 2020.Prof. Toshio Ohshiro, founder of “Laser Therapy” charged us to manage the Journal and we want to thank him for the trust placed in us, as well as for the enormous work done during these many long years. However, he will remain our point of reference as “Old Editor-in-Chief and Founder”.We want to remember our friends who have supported the newspaper over the years and who are no longer with us: Kenij Yoshida, Abraham Baruchin and Kazuhiko Atsumi: may they rest in peace.The realization of this issue was full of difficulties and required a lot of work on our part, but we did our best to get to the final result because we think that it may represent a sign of recovery of a normality after the COVID emergency.For this issue we have decided to offer readers open access to all articles and authors the opportunity to publish at no cost.The publisher is an Italian company, FILODIRITTO (www.filodiritto.com), and with the help of the Head of the Organizational Secretariat, Ms. Roberta Miano, we want to be able, for the Autumn issue, to inaugurate a new website and an automatic submission system. Last but not least, we want to thank all the Institutions, Societies and Associations that have supported “Laser Therapy” in these years. We ask them to go on to choose it for next years. We thank all of you, Authors, Board Members, Reviewers and Readers, with the prayers of giving us the great help we need. | [
"Biomedical Engineering",
"Surgery"
] | |
Acryl Fibres for the Isolation of Human Lymphocytes | [
"Hematology"
] | ||
Resistance of certain alfalfa cultivars (Medicago sativa L.) to root rot in field conditions | nema | Biotehnologija u stocarstvu, Biotechnology in Animal Husbandry | [
"Applied Mathematics"
] |
Abstract A57: Platinum induces IL-6-signaling mediated activation of ALDH1A1 and enriches the cancer stem cell population in ovarian cancer. | Abstract Purpose: While chemotherapy may succeed initially at decreasing the number of ovarian cancer (OC) cells, it leaves behind tumors enriched in ovarian cancer stem cells (OCSCs), which most likely drive chemoresistance and tumor relapse. An emerging model indicates that non-OCSCs may dedifferentiate and acquire stem cell properties under certain circumstances. Recent studies in OC implicate a critical role for aberrant cytokine interleukin-6 (IL-6) secretion and the IL-6 signaling pathway may play a critical role in converting non-CSCs to CSC. In the current study, we investigated the mechanism contributing to OCSC enrichment after platinum treatment in vivo. We hypothesize that platinum-induced IL-6 secretion activates STAT3 signaling-mediated expression of the cancer stem cell marker ALDH1A1, resulting in CSC enrichment. In addition, based on our previous study in OCSCs (Wang et al., 2014, Cancer Res.), we sought to examine the mechanism by which guadecitabine (SGI-110), a second generation hypomethylating agent HMA, inhibits OCSCs in OC xenograft residuals after platinum treatment. Methods: OC cells (OVCAR4 and A2780) were cultured alone or co-cultured with normal omental fibroblasts (NOFs) or guadecitabine (100nM, 3days)-treated NOFs in the starving condition for 24h and then treated with 3h cisplatin (CDDP; respective IC50 doses of 27.4 and 14.7μM), guadecitabine, IL-6 (100ng/ml), neutralizing antibody (Nab) against IL-6 (IL-6-Nab, 200ng/mL) or IL-6+IL-6-Nab. IL-6 secretion levels were measured by ELISA. FACS was used to analyze OCSC population marked as aldehyde dehydrogenase (ALDH)+ cells, and western blot was used to examine ALDH1A1 and pSTAT3 levels in cells treated as described above. An ALDH1A1 promoter-luciferase reporter (pGL3-ALDH1A1-Luc; -1 to -1031) assay was used to determine whether IL-6 transactivates ALDH1A1 expression in OC cells. OC cell migration under the described conditions was determined by transwell migration assays. Results: We found that CDDP induced (P<0.05) IL-6 secretion by OCs up to 48h post-treatment and up to 96h by NOFs or by co-cultured cells, suggesting a role of the tumor microenvironment in platinum-induced IL-6 secretion. Guadecitabine inhibited (P<0.05) CDDP-induced IL-6 secretion by NOFs alone or in co-culture with OVCAR4, suggesting an inhibitory role of the HMA on IL-6 signaling. By assaying FACS sorted ALDH+/- cells, we determined that ALDH+ cells express increased (P<0.05) levels of the IL-6 receptor and secrete higher (P<0.05) levels of IL-6 in the conditioned media compared to ALDH- cells. Treatment of OC cells with IL-6 enriched the percentage of ALDH+, which was inhibited by IL-6-Nab. Luciferase assay results revealed that IL-6 transactivated (p<0.05) ALDH1A1 reporter gene expression in ALDH- cells, which was blocked by IL-6-Nab. Further, we observed that IL-6- or CDDP-treated OC cells increased (P<0.05) ALDH1A1 and pSTAT3 protein expression, and guadecitabine treatment inhibited (P<0.05) expression of ALDH1A1 and pSTAT3 in OCs. ALDH+ cells showed greater migration potential than ALDH- cells, and guadecitabine inhibited (P<0.05) migration of both ALDH+ and ALDH- cells. Guadecitabine, alone or combination with IL-6-Nab, inhibited (P<0.05) CDDP-induced OVCAR4 migration in co-culture with NOFs. Conclusion: Our data indicate that IL-6 is a potent regulator of ALDH1A1 expression and the OCSC phenotype and further suggest an inhibitory effect of guadecitabine on the conversion of non-OCSCs to OCSCs. The data support a role for IL-6 in OCSC enrichment after platinum treatment and suggest that a combination approach of IL-6 neutralizing antibody with guadecitabine could represent a novel maintenance strategy after chemotherapy for eradicating OCSCs and preventing tumor recurrence. Citation Format: Yinu Wang, Anirban Kumar Mitra, Kenneth P. Nephew. Platinum induces IL-6-signaling mediated activation of ALDH1A1 and enriches the cancer stem cell population in ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr A57. | [
"Cancer Research",
"Oncology"
] | |
No Flames in the Odyssey | In one of the most stimulating chapters of his recent contribution to Homeric studies, Professor D. L. Page adduces considerable evidence to suggest that the traditions of the Iliad and the Odyssey diverged at a fairly early date and, like isolated dialects, came to differ appreciably in their diction. Attractive and probable as this suggestion is as a whole, it will always be possible to wonder about the details of the evidence. In this paper it is intended to wonder whether the absence of φλόξ and its cognates from that part of the Odyssey that is certainly ‘Homer's’ is rightly adduced as evidence for this divergence of the traditions.Page's argument runs as follows. The absence of φλόξ must be due either to ignorance or to chance. But it cannot be due to chance, since there are more than fifty opportunities for its use. Therefore the root, so common in the Iliad, must have been ‘wholly unknown to the Odyssean poet’.It appears that in order to show that φλόξ was not part of the Odyssey's traditional vocabulary, since it is this that diverges from the Iliad, Page must claim that the root was not part of the poet's vocabulary at all. Can this be regarded as a probable claim? Our available evidence is scarcely sufficient to differentiate the sub-dialects of Ionic (it is admitted that both poets are Ionians), so that it is impossible to confirm that differences of nontechnical vocabulary were a feature of the differentiation. Our view of the matter has therefore to depend on a subjective estimate of the probabilities. Two points are not unworthy of notice: first, the banishing of φλόξ from the Odyssey is only achieved by the attribution to a rhapsodic hack of the ‘Continuation’, where in ω 71, φλόξ appears in just the circumstances where, as I hope to show, it is to be expected; and second, derivatives of the root are used by prose and verse writers both Ionian and Attic, and also in the κοινή, in circumstances that make it impossible to suppose that every instance is a reminiscence of a long defunct epic word. | The Journal of Hellenic Studies | [
"Literature and Literary Theory",
"Linguistics and Language",
"Archeology",
"Visual Arts and Performing Arts",
"Language and Linguistics",
"Classics"
] |
Effect of Methyl Substitution on Molecular Shapes and Dimensions of Phenanthrenes and Benz[a]anthracenes | [
"Materials Chemistry",
"Organic Chemistry",
"Polymers and Plastics"
] | ||
Preparation and ionic selectivity of carbon-coated alumina nanofiber membranes | [
"Geochemistry and Petrology",
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
Single Phase Bidirectional H6 Rectifier/Inverter | IEEE Transactions on Power Electronics | [
"Electrical and Electronic Engineering"
] | |
Individuelle Therapieziele für Kleinkinder, Kinder und Jugendliche mit Diabetes | [
"Endocrinology, Diabetes and Metabolism"
] | ||
La tradition manuscrite de la Rhétorique à Alexandre : prolégomènes à une nouvelle édition critique | [
"Literature and Literary Theory"
] | ||
Innovation System Effects on Technological Adoption in a Regional Value Chain | [
"Geography, Planning and Development"
] | ||
Apparatus for performing ultrasonic measurements U.S. Patent No. 4,961,346 (9 Oct. 1990) | [
"Mechanical Engineering",
"Condensed Matter Physics"
] | ||
Temperature-Responsive Intumescent Chemistry toward Fire Resistance and Super Thermal Insulation under Extremely Harsh Conditions | Chemistry of Materials | [
"Materials Chemistry"
] | |
Book Review: The Big Book of Social Media: Case Studies, Stories, Perspectives and Future Media | Journalism & Mass Communication Educator | [
"Education",
"Communication"
] | |
Palbociclib: efficacious but predictive biomarkers still needed | [
"Oncology"
] | ||
Hypertriglyceridemia and Its Pharmacologic Treatment Among US Adults—Invited Commentary | [
"Internal Medicine"
] | ||
Idarucizumab (Praxbind®) for dabigatran reversal in patients undergoing heart transplantation: a cohort of ten patients | Background: Novel oral anticoagulants are used in atrial fibrillation. Idarucizumab has been approved for reversal of dabigatran in situations of life-threatening hemorrhage or emergency surgery. Objectives: We report a single center experience of ten patients on dabigatran therapy who were given idarucizumab prior to heart transplantation. Methods & results: The mean plasma concentration of dabigatran prior to reversal was 139 ± 89 ng/ml. Hemoglobin, hematocrit and platelet levels were decreased after surgery. Surgical procedures were successfully performed with no increased risk, especially regarding bleeding complications. All patients were alive after 90 days. Conclusion: Dabigatran reversal with idarucizumab in contexts of emergency surgery/urgent procedures is an attractive and safe option to be taken into consideration for patients with end stage heart disease awaiting transplantation and indication of anticoagulant therapy. | [
"Biotechnology"
] | |
The Beautiful in 1840 | [
"Education"
] | ||
The role of de novo mutations in the genetics of autism spectrum disorders | [
"Genetics (clinical)",
"Genetics",
"Molecular Biology"
] | ||
Book Review: Empires of Entertainment: Media Industries and the Politics of Deregulation, 1980–1996 | [
"Communication"
] | ||
Bogotá y el modelo de localización urbana | En este documento se realiza un análisis de ordenamiento urbano territorial de la ciudad de Bogotá. Inicialmente se hace una descripción del modelo de ordenamiento urbano neoclásicocontrastándolo con la evidencia histórica de la ciudad. A su vez se muestra el proceso de transición de un modelo ciudad monocéntrica a un modelo de ciudad policéntrica, derivado de las dinámicas de concentración de la actividad económica. Dicho proceso se genera a través de la saturación de actividades que se produjeron a partir del núcleo central de actividades - teorema del lugar central (Christaller, W. 1933)- y la aparición de centros alejados de este núcleo, los cuales presentan una menor jerarquía; esto significa que no hay una desvinculación con el núcleo principal y enmarca el ordenamiento urbano de la ciudad. Finalmente, se presentan los centros de actividad mediante metodologías de concentración de empleo y precios del suelo, lo cual refleja la dinámica de ordenamiento territorial de la ciudad de Bogotá. | [
"Computer Science Applications",
"History",
"Education"
] | |
Integrated primary care in Germany: the road ahead | [
"Health Policy",
"Sociology and Political Science",
"Health (social science)"
] | ||
Hemodiabsorption in the Treatment of Acute Hepatic Failure | [
"Biomedical Engineering",
"Biomaterials",
"Bioengineering",
"Biophysics"
] | ||
Time-Dependent coupled geminal approach for many-electron atomic structure calculations | [
"Condensed Matter Physics",
"Mathematical Physics",
"Atomic and Molecular Physics, and Optics"
] | ||
Studies in Black-Water Fever | [
"Virology",
"Infectious Diseases",
"Parasitology"
] | ||
The Multilingual Mental Lexicon and Lemma Transfer in Third Language Learning | International Journal of Multilingualism | [
"Linguistics and Language",
"Language and Linguistics"
] | |
Amorphous NiCoB nanoalloy modified Mn0.05Cd0.95S for photocatalytic hydrogen evolution | [
"Physical and Theoretical Chemistry",
"Process Chemistry and Technology",
"Catalysis"
] | ||
Intraoperative radiotherapy with low-energy x-rays after neurosurgical resection of brain metastases—an Augsburg University Medical Center experience | Abstract Purpose External-beam radiotherapy (EBRT) is the predominant method for localized brain radiotherapy (LBRT) after resection of brain metastases (BM). Intraoperative radiotherapy (IORT) with 50-kV x‑rays is an alternative way to focally irradiate the resection cavity after BM surgery, with the option of shortening the overall treatment time and limiting normal tissue irradiation. Methods We retrospectively analyzed the outcomes of all patients who underwent neurosurgical resection of BM and 50-kV x‑ray IORT between 2013 and 2020 at Augsburg University Medical Center. Results We identified 40 patients with 44 resected BM treated with 50-kV x‑ray IORT. Median diameter of the resected metastases was 2.8 cm (range 1.5–5.9 cm). Median applied dose was 20 Gy. All patients received standardized follow-up (FU) including 3‑monthly MRI of the brain. Mean FU was 14.4 months, with a median MRI FU for alive patients of 12.2 months. Median overall survival (OS) of all treated patients was 26.4 months (estimated 1‑year OS 61.6%). The observed local control (LC) rate of the resection cavity was 88.6% (estimated 1‑year LC 84.3%). Distant brain control (DC) was 47.5% (estimated 1‑year DC 33.5%). Only 25% of all patients needed WBI in the further course of disease. The observed radionecrosis rate was 2.5%. Conclusion IORT with 50-kV x‑rays is a safe and appealing way to apply LBRT after neurosurgical resection of BM, with low toxicity and excellent LC. Close MRI FU is paramount to detect distant brain failure (DBF) early. | [
"Oncology",
"Radiology, Nuclear Medicine and Imaging"
] | |
Molecular diversity in several pyridyl based Cu(ii) complexes: biophysical interaction and redox triggered fluorescence switch | A novel approach for detection of intra-cellular Cu+inE. coliand human blood cells is reported. Studies on several pyridyl based Cu(ii) complexes and interaction of ct DNA with one of them are carried out for plausible application in biology concerning disruption of normal DNA activity. | [
"Materials Chemistry",
"Catalysis"
] | |
A catalogue of RR Lyrae stars from the Northern Sky Variability Survey | Abstract A search for RR Lyrae stars has been conducted in the publicly available data of the Northern Sky Variability Survey. Candidates have been selected by the statistical properties of their variation; the standard deviation, skewness and kurtosis with appropriate limits determined from a sample 314 known RRab and RRc stars listed in the General Catalogue of Variable Stars. From the period analysis and light-curve shape of over 3000 candidates 785 RR Lyrae have been identified of which 188 are previously unknown. The light curves were examined for the Blazhko effect and several new stars showing this were found. Six double-mode RR Lyrae stars were also found of which two are new discoveries. Some previously known variables have been reclassified as RR Lyrae stars and similarly some RR Lyrae stars have been found to be other types of variable, or not variable at all. | [
"Space and Planetary Science",
"Astronomy and Astrophysics"
] | |
Prof. Dr. Wilhelm Schneider (1910-2003) | [
"Dermatology"
] | ||
Conversion efficiency versus sensitizer for electrospun TiO2nanorod electrodes in dye-sensitized solar cells | [
"Electrical and Electronic Engineering",
"Mechanical Engineering",
"Mechanics of Materials",
"Bioengineering"
] | ||
Isotrifoliol inhibits pro-inflammatory mediators by suppression of TLR/NF-κB and TLR/MAPK signaling in LPS-induced RAW264.7 cells | [
"Pharmacology",
"Immunology",
"Immunology and Allergy"
] | ||
Spectrum of the planetary nebula BD+30�3639 in the near-infrared region | Astrophysics | [
"Astronomy and Astrophysics"
] | |
High Gravity Fermentation of Sugarcane Bagasse Hydrolysate by Saccharomyces pastorianus to Produce Economically Distillable Ethanol Concentrations: Necessity of Medium Components Examined | A major economic obstacle in lignocellulosic ethanol production is the low sugar concentrations in the hydrolysate and subsequent fermentation to economically distillable ethanol concentrations. We have previously demonstrated a two-stage fermentation process that recycles xylose with xylose isomerase to increase ethanol productivity, where the low sugar concentrations in the hydrolysate limit the final ethanol concentrations. In this study, three approaches are combined to increase ethanol concentrations. First, the medium-additive requirements were investigated to reduce ethanol dilution. Second, methods to increase the sugar concentrations in the sugarcane bagasse hydrolysate were undertaken. Third, the two-stage fermentation process was recharacterized with high gravity hydrolysate. It was determined that phosphate and magnesium sulfate are essential to the ethanol fermentation. Additionally, the Escherichia coli extract and xylose isomerase additions were shown to significantly increase ethanol productivity. Finally, the fermentation on hydrolysate had only slightly lower productivity than the reagent-grade sugar fermentation; however, both fermentations had similar final ethanol concentrations. The present work demonstrates the capability to produce ethanol from high gravity sugarcane bagasse hydrolysate using Saccharomyces pastorianus with low yeast inoculum in minimal medium. Moreover, ethanol productivities were on par with pilot-scale commercial starch-based facilities, even when the yeast biomass production stage was included. | [
"Plant Science",
"Biochemistry, Genetics and Molecular Biology (miscellaneous)",
"Food Science"
] | |
Commercial method of preparing phthazine | [
"Drug Discovery",
"Pharmacology"
] | ||
Screening for Mild Cognitive Impairment in the Preoperative Setting: A Narrative Review | Cognitive impairment predisposes patients to the development of delirium and postoperative cognitive dysfunction. In particular, in older patients, the adverse sequelae of cognitive decline in the perioperative period may contribute to adverse outcomes after surgical procedures. Subtle signs of cognitive impairment are often not previously diagnosed. Therefore, the aim of this review is to describe the available cognitive screeners suitable for preoperative screening and their psychometric properties for identifying mild cognitive impairment, as preoperative workup may improve perioperative care for patients at risk for postoperative cognitive dysfunction. Electronic systematic and snowball searches of PubMed, PsycInfo, ClinicalKey, and ScienceDirect were conducted for the period 2015–2020. Major inclusion criteria for articles included those that discussed a screener that included the cognitive domain ‘memory’, that had a duration time of less than 15 min, and that reported sensitivity and specificity to detect mild cognitive impairment. Studies about informant-based screeners were excluded. We provided an overview of the characteristics of the cognitive screener, such as interrater and test-retest reliability correlations, sensitivity and specificity for mild cognitive impairment and cognitive impairment, and duration of the screener and cutoff points. Of the 4775 identified titles, 3222 were excluded from further analysis because they were published prior to 2015. One thousand four hundred and forty-eight titles did not fulfill the inclusion criteria. All abstracts of 52 studies on 45 screeners were examined of which 10 met the inclusion criteria. For these 10 screeners, a further snowball search was performed to obtain related studies, resulting in 20 articles. Screeners included in this review were the Mini-Cog, MoCA, O3DY, AD8, SAGE, SLUMS, TICS(-M), QMCI, MMSE2, and Mini-ACE. The sensitivity and specificity range to detect MCI in an older population is the highest for the MoCA, with a sensitivity range of 81–93% and a specificity range of 74–89%. The MoCA, with the highest combination of sensitivity and specificity, is a feasible and valid routine screening of pre-surgical cognitive function. This warrants further implementation and validation studies in surgical pathways with a large proportion of older patients. | Healthcare | [
"Health Information Management",
"Health Informatics",
"Health Policy",
"Leadership and Management"
] |
Government Watch: Global pollutant release agreement finalized | [
"Environmental Chemistry"
] | ||
Author Index for Volume 197 | [
"Cell Biology",
"Developmental Biology",
"Molecular Biology"
] | ||
Association of Chernobyl-derived 239+240 Pu, 241 Am, 90 Sr and 137 Cs with different molecular size fractions of organic matter in the soil solution of two grassland soils | [
"Radiation",
"Biophysics"
] | ||
Impact of COVID-19 pandemic in Spanish Nephrology Servicesservices impact of the pandemic on COVID-19 Spanish Nephrology Services | [
"Nephrology"
] | ||
Uncertainties in ab initio nuclear structure calculations with chiral interactions | We present theoretical ground state energies and their uncertainties for p-shell nuclei obtained from chiral effective field theory internucleon interactions as a function of chiral order, fitted to two- and three-body data only. We apply a Similary Renormalization Group transformation to improve the numerical convergence of the many-body calculations, and discuss both the numerical uncertainties arising from basis truncations and those from omitted induced many-body forces, as well as chiral truncation uncertainties. With complete Next-to-Next-to-Leading (N2LO) order two- and three-body interactions, we find significant overbinding for the ground states in the upper p-shell, but using higher-order two-body potentials, in combination with N2LO three-body forces, our predictions agree with experiment throughout the p-shell to within our combined estimated uncertainties. The uncertainties due to chiral order truncation are noticeably larger than the numerical uncertainties, but they are expected to become comparable to the numerical uncertainties at complete N3LO. | Frontiers in Physics | [
"Physical and Theoretical Chemistry",
"Mathematical Physics",
"Materials Science (miscellaneous)",
"Biophysics"
] |
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