Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
170: The association between weighted Adverse Outcome Index score and race/ethnicity in the U.S | [
"Obstetrics and Gynecology"
] | ||
Robustness as a criterion for use of hollow clay masonry units in seismic zones: an attempt to propose the measure | [
"Mechanics of Materials",
"Building and Construction",
"Civil and Structural Engineering"
] | ||
Editorial Board | [
"Infectious Diseases",
"Microbiology (medical)"
] | ||
Multi‐Mode White Light Emission in a ZnII Coordination Polymer from Excited‐State Intramolecular Proton Transfer (ESIPT) Ligands | [
"Inorganic Chemistry"
] | ||
The Parental Bonding Instrument: a measure of perceived or actual parental behavior? | [
"Psychiatry and Mental Health"
] | ||
Xabier Agirre, Morten Bergsmo, Simon De Smet and Carsten Stahn (eds), Quality Control in Criminal Investigation | [
"Law",
"Sociology and Political Science"
] | ||
TACT IN THE MANAGEMENT OF THE INSANE | [
"Psychiatry and Mental Health"
] | ||
ERRATUM | [
"Physiology"
] | ||
Metabolism of N-Nitrosohexamethyleneimine2 | [
"Cancer Research",
"Oncology"
] | ||
Analysis of archives infrastructure in South Africa | Purpose The purpose of this study is to assess the extent to which the Mpumalanga Provincial Archives (MPA) complies with the Mpumalanga Archives Act, 2008 legislative/policy provisions of archives building, capacity building and electronic records management and to suggest recommendations for effective archives and records management (ARM) programme in South Africa. Design/methodology/approach This paper adopts a quantitative approach supplemented by qualitative data using document review to collect data and content analysis. Findings The results show that MPA enacted Mpumalanga Archives Act, 2008. However, the challenge is the implementation of such legislation. The findings of this paper would contribute towards the literature in archival legislation in South Africa and other parts of the world. Research limitations/implications Even though the paper was based in South Africa, it was limited to the MPA of South Africa. Practical implications The findings are expected to be instrumental in the implementation of Mpumalanga Archives Act, 2008. Social implications The findings and recommendations will help in guiding MPA on the implementation of an effective provincial archive and records to facilitate the effective management of records to determine those of archival value, to preserve them for posterity and to make them accessible to the public. Originality/value This is an original study using a document review to review the Mpumalanga Archives Act, 1998. The effective archives infrastructure will contribute to compliance with legislative components such as archives building, cooperation, ERMS, appraisal and disposal of records, archives advisory body and access to information. | [
"Library and Information Sciences"
] | |
Synthesis, characterization and crystal structures of a pair of azido-bridged polynuclear Schiff base copper(II) complexes with urease inhibitory activity | [
"Materials Chemistry",
"Metals and Alloys",
"Inorganic Chemistry"
] | ||
The Effect of Bivalent Cations on the Physicochemical Properties and Structure of Borosilicate Glasses | [
"Materials Chemistry",
"Mechanics of Materials",
"Ceramics and Composites"
] | ||
Tactile Low Frequency Vibration in Dementia Management: A Scoping Review Protocol | Dementia is a growing issue in modern society. Non-pharmacological interventions such as music are suggested as the primary methods for symptom management. Therapeutic potential may also be found in sound/mechanical low frequency vibrations (LFV) that share the core characteristics of music, but these are lesser understood. The aim of the proposed scoping review is to explore the responses of persons with dementia to LFV, e.g., vibroacoustic therapy or whole-body vibration. The scoping review will follow the Joanna Briggs Institute methodology guidelines. An extensive search in BMC, CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, ERIC, MEDLINE (OvidSP), Pedro, ProQuest Central, PsycINFO, Scopus, Web of Science, and grey literature sources in Clinical Trials, Current Controlled Trials, Google Scholar, and manual search of relevant journals is planned to find all relevant research papers. The paper selection, full-text assessment, and data extraction will be performed by two independent reviewers. Participants’ responses to the interventions and the experiment designs, including methodological challenges, will be analysed and compared. Results may highlight potential gaps in reporting and comparing sound and mechanical vibration approaches and promote better understanding of their potential for managing the symptoms of dementia. Furthermore, the possible relationships between LFV and music-based interventions may become clearer. | [
"Health, Toxicology and Mutagenesis",
"Public Health, Environmental and Occupational Health"
] | |
云开地区燕山晚期花岗岩的岩石成因及构造意义：锆石 Ｕ Ｐ ｂ年龄及 Ｈ ｆ同位素证据 云开地区燕山晚期花岗岩的岩石成因及构造意义：锆石 Ｕ Ｐ ｂ年龄及 Ｈ ｆ同位素证据 | [
"Computer Science Applications",
"Building and Construction"
] | ||
A Translational Model for Diet-related Atherosclerosis | Models of atherosclerosis are used in preclinical studies but often fail to translate to humans. A model that better reflects human atherosclerosis is necessary. We recently engineered the ExeGen™ low-density lipoprotein receptor (LDLR) miniswine, in which the LDL receptor gene is modified to drive hypercholesterolemia and atherosclerosis, and showed diet-related exacerbation of these phenotypes. Five groups of animals, either wild type (+/+) or heterozygous (+/−), were fed either a normal or high-fat diet for 6 months. One group of heterozygous pigs fed a high-fat diet was also administered atorvastatin at 3 mg/kg/day. Clinical chemistry and anatomic pathology parameters were measured biweekly and at termination. The high-fat diet resulted in increased adiposity and interspersion of adipocytes within the salivary glands. The heterozygous pigs on the high-fat diet gained more weight and had significant increases in total cholesterol, high-density lipoprotein, and LDL compared to wild-type animals or heterozygous animals fed a normal diet. Atorvastatin attenuated these parameters, indicating the statin had a beneficial effect, even in a high-fat diet scenario. Atorvastatin treatment also reduced the intensity of Oil Red O staining in pigs on high-fat diet. Atorvastatin-related amelioration of several indices of cardiovascular pathophysiology in this model underscores its utility for drug discovery. | [
"Cell Biology",
"Toxicology",
"Molecular Biology",
"Pathology and Forensic Medicine"
] | |
Oxytocin retrogradely inhibits evoked, but not miniature, EPSCs in the rat supraoptic nucleus: role of N‐ and P/Q‐type calcium channels | [
"Physiology"
] | ||
Syndroom van Paget-Schrötter bij een assembleur | [
"Health Information Management",
"Health Policy",
"Health (social science)"
] | ||
Solar water heating in Cyprus: current status of technology and problems | [
"Renewable Energy, Sustainability and the Environment"
] | ||
The place of behavioral sciences in graduate training in international relations | [
"Information Systems and Management",
"Strategy and Management"
] | ||
Interferon-λ3 Exacerbates the Inflammatory Response to Microbial Ligands: Implications for SARS-CoV-2 Pathogenesis | [
"Immunology",
"Immunology and Allergy"
] | ||
Effect of structure on the fatigue strength of dispersion-hardened condensated based on copper II. Analysis of the first coefficient of the Mott—Stroh relation | Powder Metallurgy and Metal Ceramics | [
"Materials Chemistry",
"Metals and Alloys",
"Mechanics of Materials",
"Condensed Matter Physics",
"Ceramics and Composites"
] | |
S2237 Lyme Arthritis Mimicking Inflammatory Bowel Disease-Associated Arthritis in Patient With Crohn’s Disease | [
"Gastroenterology",
"Hepatology"
] | ||
L'assurance-qualité en psychiatrie | [
"Psychiatry and Mental Health"
] | ||
Photocollage as a Therapeutic Modality for Working with Groups | [
"Social Sciences (miscellaneous)",
"Education"
] | ||
Zum Problem der eingeschleppten Verunreinigungen bei der präparativen Dünnschichtchromatographie | [
"Clinical Biochemistry",
"Analytical Chemistry"
] | ||
Publication Briefs | [
"Management, Monitoring, Policy and Law",
"Tourism, Leisure and Hospitality Management",
"Geography, Planning and Development",
"Cultural Studies"
] | ||
Inhibition of Egr-1 by siRNA in prostate carcinoma cell lines is associated with decreased expression of AP-1 and NF-κB | [
"Genetics"
] | ||
Determination of Nicotine by Surface-Enhanced Raman Scattering (SERS) | The analytical application of surface-enhanced Raman spectroscopy (SERS) to the determination of nicotine is demonstrated. A simple spectroelectrochemical method using a copper or silver electrode as the SERS substrate has been developed, consisting of three steps: polishing a working electrode to a mirror finish; roughening the electrode in an electrolyte solution; and, finally, depositing the nicotine analyte onto the roughened electrode after immersion in a sample solution. During the reduction cycle, a large enhancement in nicotine Raman scattering is observed at the electrode surface. The intensity of the SERS signal on a silver electrode is linear with concentration from 10 to 900 ppb, with an estimated detection limit of 7 ppb. The total analysis time per sample is approximately five minutes. This procedure has been used to analyze the extract from a cigarette side-stream smoke sample (environmental tobacco smoke); the SERS results agree well with those of conventional gas chromatographic analysis. | [
"Spectroscopy",
"Instrumentation"
] | |
Regulation of ketogenesis in the liver | [
"Biochemistry"
] | ||
“Between-group psychotherapy outcome research and basic science” revisited | [
"Arts and Humanities (miscellaneous)",
"Clinical Psychology"
] | ||
Aus Der Branche | [
"Marketing",
"Visual Arts and Performing Arts",
"Ceramics and Composites"
] | ||
PP-143 BILATERAL CAROTID ARTERY STENTING IN A HIGH RISK PATIENT | [
"Cardiology and Cardiovascular Medicine"
] | ||
Medical Notes | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
Book Review: Emergency vascular and endovascular surgical practice, 2nd edition | [
"Cardiology and Cardiovascular Medicine"
] | ||
Stimulation of P-Glycoprotein ATPase by Analogues of Tetramethylrosamine: Coupling of Drug Binding at the “R” Site to the ATP Hydrolysis Transition State | [
"Biochemistry"
] | ||
The relationships of a rationality/antiemotionality personality scale to mortalities of cancer and cardiovascular disease in a community population in Japan | [
"Psychiatry and Mental Health",
"Clinical Psychology"
] | ||
Enumeration of non-positive planar trivalent graphs | Journal of Algebraic Combinatorics | [
"Discrete Mathematics and Combinatorics",
"Algebra and Number Theory"
] | |
BRITISH SOCIETY FOR THE PHILOSOPHY OF SCIENCE | [
"History and Philosophy of Science",
"Philosophy",
"History"
] | ||
The Kreisky phenomenon | [
"Political Science and International Relations"
] | ||
Catecholamine Effects on Testicular Testosterone Production in the Gonadally Active and the Gonadally Regressed Adult Golden Hamster1 | [
"Cell Biology",
"Reproductive Medicine"
] | ||
A Comparative Analysis Of Stapler Versus Harmonic Scalpel In Major Liver Resections | [
"Gastroenterology",
"Hepatology"
] | ||
Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity | ImportanceIbrutinib has been associated with serious cardiotoxic arrhythmias. In preclinical models, these events are paralleled or proceeded by diffuse myocardial injury (inflammation and fibrosis). Yet whether this is seen in patients or has implications for future cardiotoxic risk is unknown.ObjectiveTo assess the incidence and outcomes of myocardial injury among patients with ibrutinib-related cardiotoxicity.Design, Setting, and ParticipantsThis cohort study included consecutive patients treated with ibrutinib from 2012 to 2019, phenotyped using cardiovascular magnetic resonance (CMR) from a large US Comprehensive Cancer Center registry.ExposuresIbrutinib treatment for cancer control.Main Outcomes and MeasuresThe primary outcome was the presence of late gadolinium enhancement (LGE) fibrosis. The secondary outcome was the occurrence of major adverse cardiac events (MACE), defined as atrial fibrillation, heart failure, symptomatic ventricular arrhythmias, and sudden death of probable or definite ibrutinib association after CMR. We also assessed parametric-mapping subclinical fibrosis (native-T1, extracellular volume fraction) and inflammation/edema (max-T2) measures. Cardiovascular magnetic resonance measures were compared with those obtained in similar consecutive patients with cancer without ibrutinib treatment (pretreatment controls). Observed measures were also compared with similar-aged broad population rates (general-population controls) and a broader pool of cardiovascular disease (CVD) risk–matched cancer controls. Multivariable regression was used to assess the association between CMR measures and MACE.ResultsOverall, 49 patients treated with ibrutinib were identified, including 33 imaged after treatment initiation (mean [SD] age, 65 [10] years, 9 [27%] with hypertension, and 23 [69.7%] with index-arrhythmias); median duration of ibrutinib-use was 14 months. The mean (SD) pretreatment native T1 was 977.0 (73.0) ms, max-T2 56.5 (4.0) ms, and 4 (13.3%) had LGE. Posttreatment initiation, mean (SD) native T1 was 1033.7 (48.2) ms, max-T2 61.5 (4.8) ms, and 17 (54.8%) had LGE (P < .001, P = .01, and P < .001, respectively, pre- vs post-ibrutinib treatment). Native T12SDs was elevated in 9 (28.6%), and max-T22SDs in 21 (63.0%), respectively. Cardiovascular magnetic resonance measures were highest in those with suspected toxic effects (P = .01 and P = .01, respectively). There was no association between traditional CVD-risk or cancer-treatment status and abnormal CMR measures. Among those without traditional CVD, 16 (58.6%) had LGE vs 38 (13.3%) in matched-controls (relative-risk, 4.8; P < .001). Over a median follow-up of 19 months, 13 (39.4%) experienced MACE. In multivariable models inclusive of traditional CVD risk factors, LGE (hazard ratio [HR], 4.9; P = .04), and native-T12SDs (HR, 3.3; P = .05) associated with higher risks of MACE.Conclusions and RelevanceIn this cohort study, myocardial injury was common in ibrutinib users, and its presence was associated with higher cardiotoxic risk. | [
"Oncology",
"Cancer Research"
] | |
Migratory response of polar bears to sea ice loss: to swim or not to swim | [
"Ecology, Evolution, Behavior and Systematics"
] | ||
Influence of host-plant quality on the performance of Episimus unguiculus, a candidate biological control agent of Brazilian peppertree in Florida | [
"Insect Science",
"Agronomy and Crop Science"
] | ||
Application of Trapezoid Orbital Septum Membrane Flap in Double-Eyelid Blepharoplasty | Annals of Plastic Surgery | [
"Surgery"
] | |
Bubble diameter correlation via numerical experiment | [
"Industrial and Manufacturing Engineering",
"Environmental Chemistry"
] | ||
A General Route to Efficient Functionalization of Silicon Quantum Dots for High-Performance Fluorescent Probes | Small | [
"Biomaterials",
"Biotechnology"
] | |
Synthetic experiments related to the indole alkaloids V. mercuric acetate oxidation of 2-[2-(3-indolyl)ethyl]-1,2,3,4-tetrahydroisoquinolines and the formation of benz[a]indolo[3,2-h]quinolizine derivatives | [
"Organic Chemistry"
] | ||
Alzheimer neurofibrillary change in subacute sclerosing panencephalitis | [
"Neurology (clinical)",
"Neurology"
] | ||
OC-0179: Dosimetric impact of errors in HDR-iBT of the breast using a catheter tracking method | [
"Radiology, Nuclear Medicine and Imaging",
"Oncology",
"Hematology"
] | ||
Prediction of the Spatial Variability of Diagenesis and Porosity Using Sequence Stratigraphy in Middle Carboniferous carbonates from Southern Kazakhstan: Implications for North Caspian Basin Hydrocarbon Reservoirs of the CIS : ABSTRACTS | [
"Earth and Planetary Sciences (miscellaneous)",
"Geochemistry and Petrology",
"Geology",
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
INVESTIGATION OF THE OPPORTUNITY OF EXPANSION OF THE BASE OF MINERAL RESOURCES FOR OBTAINING OF ADSORBENTS ON THE BASIS OF OPAL-CRISTOBALITE ROCKS | Bulletin of Belgorod State Technological University named after. V. G. Shukhov | [
"Pharmacology (medical)",
"Complementary and Alternative Medicine",
"Pharmaceutical Science"
] | |
Addressing Western dietary pattern in obesity and NAFLD | Abstract Background Western diet and sedentary life are imputed for non-alcoholic fatty liver disease (NAFLD). Relationship of obesity and bright liver, i.e., the ultrasound hallmarks of fatty liver, evaluated as Bright Liver Score (BLS), with Western diet pattern score (WDS) and with the level of physical exercise, assessed by the Baecke questionnaire, were investigated. Methods One hundred fifty (72 females, 78 males) NAFLD non-diabetic patients, 47.89 ± 13.85 years old, were referred to a diagnostic-therapeutic unit with the lone evidence of fatty liver as detected by an ultrasound. WDS, Adherence to Mediterranean Diet Score (AMDS), physical exercise, insulin resistance (HOMA-IR), and BMI were assessed also after 6 months of comprehensive lifestyle intervention. Results BLS, BMI, HOMA, and WDS were significantly greater, while AMDS and physical exercise were lower at the greater severity of ultrasound (US)-detected NAFLD. Positive linear correlation of WDS, BMI, and HOMA vs. BLS was present at patients’ referral. After intervention, decrease of liver dimension and of Bright Liver Score concurrent with a reduction of BMI, HOMA-IR, WDS, LDL cholesterol, and triglycerides was observed. A reciprocal increase of AMDS, physical exercise, and HDL cholesterol was also reported. Conclusions The assessment of some features of the Western diet is possible; its effect, along with overweight, is associated with a greater severity of fatty liver as evaluated by ultrasound in NAFLD. Trial registration NCT02670590. Registered on February 2, 2016. | Nutrire | [
"Public Health, Environmental and Occupational Health",
"Nutrition and Dietetics",
"Physiology",
"Biochemistry",
"Endocrinology, Diabetes and Metabolism",
"Food Science"
] |
Hormone, Vitamine | [
"Cancer Research",
"Oncology"
] | ||
Movement Disorders: Volume 32, Number 7, July 2017 | Movement Disorders | [
"Neurology (clinical)",
"Neurology"
] | |
Thermogram classification using deep siamese network for neonatal disease detection with limited data | [
"Electrical and Electronic Engineering",
"Instrumentation"
] | ||
Nutrient Transport in Surface Runoff from a Subalpine Watershed, Lake Tahoe Basin, California | [
"Ecology, Evolution, Behavior and Systematics"
] | ||
hpO: Berufsvereinigung für heilkundlich praktizierte Osteopathie e. V. | [
"Complementary and Alternative Medicine"
] | ||
Metastable state of gas hydrate during decomposition: A novel phenomenon | Chinese Journal of Chemical Engineering | [
"Biochemistry",
"Environmental Engineering"
] | |
A desirable future for technology risk management | [
"Management Science and Operations Research",
"Statistics, Probability and Uncertainty",
"Business and International Management"
] | ||
New Insights into the Adsorption of 3-(Trimethoxysilyl)propylmethacrylate on Hydroxylated ZnO Nanopowders | Langmuir | [
"Electrochemistry",
"Spectroscopy",
"Surfaces and Interfaces",
"Condensed Matter Physics"
] | |
The Role of Self-Care for Parents in Recovery From Substance Use Disorders | Journal of Addictions Nursing | [
"Psychiatry and Mental Health",
"Psychiatric Mental Health"
] | |
High level expression of a truncated β-mannanase from alkaliphilic Bacillus sp. N16-5 in Kluyveromyces cicerisporus | [
"Biotechnology",
"Bioengineering",
"Applied Microbiology and Biotechnology"
] | ||
Parasites and the Coexistence of Animal Host Species | [
"Ecology, Evolution, Behavior and Systematics"
] | ||
Extending indications in robotic partial nephrectomy: Maintaining outcomes despite increasing complexity over 200 cases | European Urology Supplements | [
"Urology"
] | |
“¡Se acerca la gripe asiática!”: crónica de una pandemia antes de su llegada (Brasil, 1957) | Introducción: este artículo analiza la llegada de la pandemia de influenza asiática a Brasil a partir de la noticia publicada entre junio y septiembre de 1957 en la prensa de la ciudad de Río de Janeiro, entonces capital federal. Las fuentes utilizadas son tres de los diarios más importantes y dos revistas semanales disponibles en línea. Desarrollo: el artículo acompaña tres meses de información, informes y opiniones sobre el surgimiento y crecimiento de la pandemia en Asia, Estados Unidos, Europa y Suramérica; la amenaza de su ingreso al país y las acciones del gobierno federal, y los primeros casos registrados en Río de Janeiro a principios de septiembre. Analiza la pandemia en Brasil a través de la lente del periodismo, abordando las percepciones e incertidumbres sobre la enfermedad y los preparativos de los gobiernos, así como de las instituciones científicas y médicas. El artículo aborda las evaluaciones y críticas a la actuación del Gobierno, las repercusiones de los primeros casos sospechosos y confirmados en América del Sur y las dudas sobre la capacidad del Ministerio de Salud para responder a la epidemia. Conclusiones: el artículo destaca el papel central de la prensa y los medios de comunicación en la configuración de la epidemia como un evento social y político antes de que ocurriera como un evento biomédico. | Revista Ciencias de la Salud | [
"Health (social science)",
"Medicine (miscellaneous)"
] |
Salinity and nutrients influence species richness and evenness of phytoplankton communities in microcosm experiments from Great Salt Lake, Utah, USA | [
"Ecology",
"Aquatic Science",
"Ecology, Evolution, Behavior and Systematics"
] | ||
Applying the prompt questions from the Cognitive Work Analysis Design Toolkit: a demonstration in rail level crossing design | Theoretical Issues in Ergonomics Science | [
"Human Factors and Ergonomics"
] | |
Urinary ultrasonography in screening incidental renal cell carcinoma: is it obligatory? | International Urology and Nephrology | [
"Urology",
"Nephrology"
] | |
Pharmacist Interventions in the Management of Blood Pressure Control and Adherence to Antihypertensive Medications: A Systematic Review of Randomized Controlled Trials | Objective: Pharmacists are ideally positioned to promote optimal use and assess the adherence of prescription medications in patients with chronic diseases. This systematic review of randomized controlled trials (RCTs) ascertains the effectiveness of pharmacist interventions to improve blood pressure (BP) control and medication adherence in patients with hypertension. Data Sources: Electronic databases were searched for studies in English published between January 1, 1995, and January 31, 2018. Eligibility criteria included patients with a diagnosis of hypertension tested with RCT where pharmacist-led interventions occurred. The primary outcome was BP control and the secondary outcome was adherence to hypertensive medication. Quality of studies was assessed using the Cochrane Risk of Bias Tool. Data Synthesis: Thirty-five studies met the inclusion–exclusion criteria and were included in this study. Major themes included pharmacist-led interventions with medication counseling, patient education, distribution of interventions materials, individualized care plans, and check-in meetings. The vast majority of trials (n = 29) showed statistically significant improvement in BP in the intervention groups at follow-up. Of the 35 studies, most (n = 20) assessed medication adherence; several trials (n = 9) showed statistically significant improvement in medication adherence in patients receiving additional pharmaceutical care services. None of the RCTs was considered to have a high risk of bias. Conclusion: Pharmacist-led interventions improved BP control and medication adherence through education, counseling, or a combination of both. Future research is needed to determine the most effective pharmacists’ interventions in managing hypertension and to assess the cost-effectiveness of these interventions. | [
"Pharmacology (medical)"
] | |
Stimulation of Insulin Release by Elevated Pressure Gradient | Endocrinology | [
"Endocrinology"
] | |
Functional equations characterizing the tangent function over a convex polygon | [
"Applied Mathematics",
"Discrete Mathematics and Combinatorics"
] | ||
Amino acid digestibility of plant protein feed ingredients for growing pigs | [
"Genetics",
"Animal Science and Zoology",
"Food Science"
] | ||
Efficacy and user acceptability of transfluthrin-treated sisal and hessian decorations for protecting against mosquito bites in outdoor bars | [
"Infectious Diseases",
"Parasitology"
] | ||
Cutaneous Granular Cell Tumors in Children: Case Series and Review of the Literature | Pediatric Dermatology | [
"Dermatology",
"Pediatrics, Perinatology and Child Health"
] | |
On the preparation of zinc ferrite single crystals by chemical transport | [
"Mechanical Engineering",
"Mechanics of Materials",
"Condensed Matter Physics"
] | ||
Luis Sáinz de Medrano, "Historia de la literatura hispanoamericana desde el modernismo" (Book Review) | [
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
Biocidal and catalytic efficiency of ruthenium(III) complexes with tridentate Schiff base ligands | Applied Organometallic Chemistry | [
"Inorganic Chemistry"
] | |
Secretion of Inorganic Phosphorus in Tears* | [
"Ophthalmology"
] | ||
Finite Elements Modelling of the γ/γ' Two-Phase Viscoplastic Behaviour | [
"Mechanics of Materials",
"Materials Science (miscellaneous)"
] | ||
Morphological transformations during Fischer-Tropsch synthesis on a titania-supported cobalt catalyst | Catalysis Today | [
"Catalysis"
] | |
Influence of Powder Type and Density on Pore Closure and Surface Hardness Changes Resulting from Steam Treatment of Sintered Iron | [
"Materials Chemistry",
"Metals and Alloys",
"Mechanics of Materials",
"Condensed Matter Physics",
"Ceramics and Composites"
] | ||
A TEST OF THE MONTE CARLO HYPOTHESIS: COMMENT* | [
"Economics and Econometrics"
] | ||
Pectus Carinatum Evaluation Questionnaire (PCEQ): a novel tool to improve the follow-up in patients treated with brace compression | [
"Cardiology and Cardiovascular Medicine",
"Pulmonary and Respiratory Medicine",
"Surgery"
] | ||
Notes on superconformal Chern-Simons-Matter theories | Journal of High Energy Physics | [
"Nuclear and High Energy Physics"
] | |
First data for sotorasib in patients with pancreatic cancer with KRAS p.G12C mutation: A phase I/II study evaluating efficacy and safety | 360490 Background: KRAS mutation is present in 90% of pancreatic ductal adenocarcinomas with p.G12C accounting for 1% to 2% of these mutations. Sotorasib, a small molecule that specifically and irreversibly inhibits KRASG12C, has been investigated in the CodeBreaK100 trial in patients with KRASG12C-mutated advanced solid tumors. Herein, we report on the largest dataset evaluating efficacy and safety of a KRASG12C inhibitor in patients with pretreated KRASG12C-mutated pancreatic cancer. Methods: CodeBreaK100 (NCT03600883) is an international, single arm, phase I/II study evaluating the efficacy and safety of sotorasib in patients with KRASG12C-mutated advanced solid tumors with ≥ 1 prior systemic therapy unless intolerant or ineligible for available therapies. The primary efficacy endpoint is confirmed objective response rate (ORR), assessed by blinded independent central review (BICR) per RECIST 1.1. Secondary endpoints include duration of response (DoR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS). Results: As of November 1, 2021, 38 patients with pancreatic cancer (mean age: 65 years, 76.3% male) from the combined phase I/II study received sotorasib 960 mg once daily. Stage IV disease was present in 55.3% of patients at diagnosis, and in all patients at enrollment. Baseline ECOG scores were 0, 1, or 2 in 31.6%, 57.9%, and 10.5% of patients, respectively. Most patients (79%) had ≥ 2 prior lines of therapy (median: 2 [range: 1-8]). Median treatment duration was 4.1 months with a median follow-up of 16.8 months. Eight patients had confirmed partial response by BICR with a resulting ORR of 21.1% (95% CI: 9.55%-37.32%). DCR was 84.2% (Table 1). Treatment-related adverse events (TRAEs) of any grade occurred in 16 (42.1%) patients. Grade ≥ 3 TRAEs occurred in 6 patients: diarrhea (2); fatigue (2); abdominal pain, ALT increase, AST increase, pleural effusion, and pulmonary embolism (1 each). No TRAEs were fatal or resulted in sotorasib discontinuation. Conclusions: Sotorasib demonstrated clinically meaningful anticancer activity and tolerability in patients with heavily pretreated KRASG12C-mutated advanced pancreatic cancer, who have limited treatment options and poor prognosis. Clinical trial information: NCT03600883. [Table: see text] | [
"Cancer Research",
"Oncology"
] | |
Uniqueness and regularity of weak solutions for the 1- degenerate Keller–Segel systems | [
"Applied Mathematics",
"Analysis"
] | ||
PRIZE FOR ENCEPHALITIS RESEARCH | [
"Psychiatry and Mental Health"
] | ||
Coupling bubble and material dynamics to model cavitation peening and pitting | [
"Fluid Flow and Transfer Processes",
"Mechanical Engineering"
] | ||
The Implications of CT Sizing on Valve Selection and Paravalvular Regurgitation in Transcatheter Aortic Valve Replacement | [
"Cardiology and Cardiovascular Medicine",
"Pulmonary and Respiratory Medicine"
] | ||
Comparison between American Upland and Asiatic Varieties of Cotton as Regards the Germination of Seeds at Low Temperatures | [
"Genetics",
"Agronomy and Crop Science",
"Food Science"
] | ||
Supracondylar humeral fractures in children | Although supracondylar fracture is a very common elbow injury in childhood, there is no consensus on the timing of surgery, approach for open reduction and positioning of fixation wires. We report our ten-year experience between 1993 and 2003 in 291 children. Most fractures (285; 98%) were extension injuries, mainly Gartland types II (73; 25%) and III (163; 56%). Six (2%) were open fractures and a neurovascular deficit was seen in 12 (4%) patients. Of the 236 children (81%) who required an operation, 181 (77%) were taken to theatre on the day of admission. Most (177; 75%) of the operations were performed by specialist registrars. Fixation was by crossed Kirschner wires in 158 of 186 (85%) patients and open reduction was necessary in 52 (22%). A post-operative neurological deficit was seen in nine patients (4%) and three (1%) required exploration of the ulnar nerve. Only 22 (4%) patients had a long-term deformity, nine (3%) from malreduction and three (1%) because of growth arrest, but corrective surgery for functional limitation was required in only three (1%) patients. | [
"Orthopedics and Sports Medicine",
"Surgery"
] | |
New Species of Cretolimonia and Mesotipula (Diptera: Limoniidae) from the Middle Jurassic of Northeastern China | [
"Geology"
] | ||
Identifikasi Permasalahan Pembelajaran PJOK di SMP/MTs Se-Kecamatan Karangsambung Pada Masa Pandemi Covid-19 Tahun Ajaran 2020/2021 | [
"Marketing",
"Organizational Behavior and Human Resource Management",
"Strategy and Management",
"Drug Discovery",
"Pharmaceutical Science",
"Pharmacology"
] | ||
The role of rapid induced resistance of host plant in trophic interactions between Betula pendula, Lymantria dispar, and Bacillus thuringiensis | [
"Ecology, Evolution, Behavior and Systematics"
] | ||
Journal of Assisted Reproduction and Genetics | [
"Genetics (clinical)",
"Developmental Biology",
"Obstetrics and Gynecology",
"Genetics",
"Reproductive Medicine"
] | ||
A Third Appearance of an Anaesthetic Committee within the British Medical Association | [
"History and Philosophy of Science",
"Anesthesiology and Pain Medicine"
] | ||
Medical waste handling and hepatitis B virus infection: A meta-analysis | [
"Infectious Diseases",
"Public Health, Environmental and Occupational Health",
"Health Policy",
"Epidemiology"
] | ||
Tick tock: can the clock be stopped? the use of elective oocyte cryopreservation (EOC) as a means to preserve fertility (PF) | [
"Obstetrics and Gynecology",
"Reproductive Medicine"
] | ||
Friction stress σ0and relationship between initial and secondary creep rates in precipitation-hardened nickel-base alloy | [
"Mechanical Engineering",
"Mechanics of Materials",
"Condensed Matter Physics"
] |
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