Title stringlengths 0 905 | Abstract stringlengths 0 11.3k | Container_Title stringlengths 0 126 | Subject listlengths 1 13 |
|---|---|---|---|
GLYCO XVIII International Symposium on Glycoconjugates: Abstracts | [
"Cell Biology",
"Molecular Biology",
"Biochemistry"
] | ||
Xanthogranuloma of the lacrimal sac as a manifestation of Wegener's granulomatosis | [
"Ophthalmology"
] | ||
A study of carbon thin films by ion beams with high energy resolution | [
"Instrumentation",
"Nuclear and High Energy Physics"
] | ||
Influenza Vaccine Progress | [
"Pharmacology (medical)",
"Pharmacology",
"Pharmacy"
] | ||
Deep Lobe Parotid Tumors: A Systematic Review and Meta‐analysis | [
"Otorhinolaryngology",
"Surgery"
] | ||
Truth on Trial: The Lawsuit Motif in the Fourth Gospel. By ANDREW T. LINCOLN. | [
"Religious Studies"
] | ||
Giant dielectric and low voltage varistor behaviors of Ba-doped Bi1/2Na1/2Cu3Ti4O12 ceramics | [
"Electrical and Electronic Engineering",
"Condensed Matter Physics",
"Atomic and Molecular Physics, and Optics",
"Electronic, Optical and Magnetic Materials"
] | ||
Bulk Ti2Nb10O29as long-life and high-power Li-ion battery anodes | [
"Renewable Energy, Sustainability and the Environment"
] | ||
New RP‐HPLC Method with UV‐Detection for the Determination of Carvedilol in Human Serum | Journal of Liquid Chromatography & Related Technologies | [
"Clinical Biochemistry",
"Pharmaceutical Science",
"Biochemistry",
"Analytical Chemistry"
] | |
Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats | [
"Pharmacology"
] | ||
A Study on Post-colonialism in Lee Kwang-woong's literature | [
"Polymers and Plastics"
] | ||
THE WORD “MANA”: A LINGUISTIC STUDY | [
"History and Philosophy of Science",
"Anthropology"
] | ||
Zum Gedenken an Dr. Jochen Tolk | [
"Rheumatology"
] | ||
The Yellow Fever Situation — Filtration of Water and Typhoid Fever — Siriasis — Plague on the Isthmus — Medical Notes | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
Unfinished books, and books announced but never published | [
"Library and Information Sciences",
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | ||
Collagen synthesis in human keloid and hypertrophic scar | [
"Surgery"
] | ||
Predicting the Onset of Alcohol Use and the Development of Alcohol Use Disorder Among Indigenous Adolescents | [
"Developmental and Educational Psychology",
"Education",
"Pediatrics, Perinatology and Child Health"
] | ||
Forthcoming meetings | [
"Complementary and Alternative Medicine"
] | ||
Synthesis and spectroscopic and magnetic properties of a unique diamagnetic binuclear .mu.-oxo vanadium(IV) complex. Crystal structure of [(tpa)VO(.mu.-O)VO(tpa)](ClO4)2 (tpa = tris(2-pyridylmethyl)amine) | [
"Inorganic Chemistry",
"Physical and Theoretical Chemistry"
] | ||
Modeling a UNI-Mosfet Switch for Single Phase System Application | The concept of replacing mechanical switcher using Solid State Devices (SSR) as the medium of relaying high power AC load has already been recommended five decades ago using Dual Thyristor or Triac. The rapid growth in SSR field has now resulted in using dual IGBTs, dual JFETs, dual MOSFETs or dual HEMTs semiconductor devices to control high powered AC loads. One of the drawbacks of all the systems above is that they all using two semiconductor devices to operate for both half cycle of the single phase AC waveform, with either anti-parallel or anti series-arrangement incorporated. We have modeled a novel SSR, using only one MOSFET semiconductor device with a new SSR module packaging. This novel Uni-MOSFET SSR is capable of operating on both half cycles of an AC waveform and eliminating problems associated with dual semiconductor SSR system. Moreover, in this paper we have explained the simulations proving that the Uni-MOSFET SSR is able to control resistive load and able to compensate capacitive and inductive as a SVC, which is as good as its predecessor the Dual-Thyristor SSR. The draw back would be the complexity of the control signals of the Uni-MOSFET SSR for TCR but we have managed to simplify using equations. Our novel SSR is cost efficient, low noise and works well as a load switcher, circuit breaker or compensation switch for single phase electrical network system. | [
"Management of Technology and Innovation"
] | |
Tungsten carbide encapsulated in nitrogen-doped carbon with iron/cobalt carbides electrocatalyst for oxygen reduction reaction | [
"Surfaces, Coatings and Films",
"Condensed Matter Physics",
"Surfaces and Interfaces"
] | ||
Vegetation cover analysis of the mountainous part of north-eastern Siberia by means of geoinformation modelling and machine learning (basic principles, approaches, technology and relation to geosystem science) | For the first time, the geoinformation modelling and machine learning approaches have been used to study the vegetation cover of the mountainous part of North-Eastern Siberia – the Orulgan medium-altitude mountain landscape province. These technologies allowed us to distinguish a number of mapping units that were used for creation and analysis of 1:100 000 scale vegetation map of the interpreted key area. Based on the studies, we decided upon the basic principles, approaches and technologies that would serve as a methodology basis for the further studies of vegetation cover of the large region. Relief, slope aspect, genetic types of sediments, and moisture conditions were selected as supplementary factors to the vegetative indices for differentiation of both plant communities and vegetation map units. | BIO Web of Conferences | [
"Industrial and Manufacturing Engineering",
"Environmental Engineering"
] |
Attitudes of the Portuguese farmers to the EU Common Agricultural Policy | [
"Agricultural and Biological Sciences (miscellaneous)"
] | ||
Centrally acting emetics. 10. Rigid dopamine congeners derived from octahydrobenzo[f]quinoline | [
"Drug Discovery",
"Molecular Medicine"
] | ||
Evolutionary positioning of outsourcing in the local public administration | [
"Management of Technology and Innovation",
"Organizational Behavior and Human Resource Management",
"Strategy and Management",
"Education",
"Accounting",
"Business and International Management"
] | ||
Interaction of herbal ingredients contained in the Trikatuk recipe: design of experiment (DOE) and chemical analysis point of view | [
"Complementary and Alternative Medicine"
] | ||
Investigation of chemical bonding states at interface of Zn/organic materials for analysis of early stage of inorganic/organic hybrid multi-layer formation | [
"Materials Chemistry",
"Metals and Alloys",
"Surfaces, Coatings and Films",
"Surfaces and Interfaces",
"Electronic, Optical and Magnetic Materials"
] | ||
Miscellany | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
PENILE STRAIGHTENING WITH CRURAL GRAFT OF THE CORPUS CAVERNOSUM | [
"Urology"
] | ||
Higher education in transition - the case of Israel - a comparative study | [
"Education"
] | ||
An evaluation of selumetinib for the treatment of neurofibromatosis type 1-associated symptomatic, inoperable plexiform neurofibromas | Expert Review of Precision Medicine and Drug Development | [
"Drug Discovery",
"Pharmacology",
"Genetics",
"Molecular Medicine"
] | |
EVALUASI SISTEM PENGENDALIAN INTERNAL ATAS PROSEDUR PENERIMAAN PENDAPATAN TRANSAKSI TOL NONTUNAI (E-TOLL) PADA PT JASA MARGA (PERSERO) TBK. CABANG PURBALEUNYI | PT Jasa Marga (Persero) Tbk. Purbaleunyi Branch is a state-owned enterprise service, as enforcement and services for the toll road. In providing services that are effective, efficient, safe, comfortable, and ease the accessibility of toll roads for users, a non-cash toll payment system is implemented (e-toll). The implementation of internal control at PT Jasa Marga (Persero) Tbk. Purbaleunyi Branch still has weaknesses, such as the placement of employees are placed unsuitable with their education and proficiency causing inefficient work. Moreover, there is no written policy on standard operating procedures regarding receipt of e-toll income and job rotation that are not routinely do so that the vulnerability of fraud occurs. This study aims to evaluate the implementation of internal control on the non-cash receipt of toll transaction procedure (e-toll) that applied by PT Jasa Marga (Persero) Tbk. Purbaleunyi Branch. The method used in this research is descriptive analytics method by taking interviews, observation, and documentation. The analytics tool used in this study is a control matrix based on the Committee of Sponsoring Organizations.Based on the results of this research, it can be concluded that internal control on the non-cash receipt of toll transaction procedure (e-toll) at PT Jasa Marga (Persero) Tbk. Purbaleunyi Branch has been adequate and effective. | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | |
Breeding of the Silvered Leaf Monkey, Presbytis cristata, in Malaya | Journal of Mammalogy | [
"Nature and Landscape Conservation",
"Genetics",
"Animal Science and Zoology",
"Ecology",
"Ecology, Evolution, Behavior and Systematics"
] | |
Reversible solid state structural transformation of a polyhapto lead(ii) polymeric chain to a tetrahapto lead(ii) two-dimensional network by thermal dehydration with no change in nanoplate morphology | CrystEngComm | [
"Condensed Matter Physics"
] | |
Spontaneous ignition of fuel-air mixture in circulation region behind poorly streamlined body | [
"Energy Engineering and Power Technology",
"Fuel Technology"
] | ||
Product reports from Japan | [
"Bioengineering",
"Biotechnology",
"Applied Microbiology and Biotechnology"
] | ||
Combinatorial behavior of extreme points of perturbed polyhedra | [
"Applied Mathematics",
"Analysis"
] | ||
Cranberry Juice Inhibits Metal and Non-Metal Initiated Oxidation of Human Low Density Lipoproteinsin vitro | Journal of Nutraceuticals, Functional & Medical Foods | [
"Food Science",
"Medicine (miscellaneous)"
] | |
Self-assembly of Au nanocrystals into large-area 3-D ordered flexible superlattice nanostructures arrays for ultrasensitive trace multi-hazard detection | [
"Health, Toxicology and Mutagenesis",
"Pollution",
"Waste Management and Disposal",
"Environmental Chemistry",
"Environmental Engineering"
] | ||
A New Synthetic Route to Acylnitroso Intermediates and Their Applications in HDA and Ene Reactions | [
"Organic Chemistry",
"Biochemistry"
] | ||
High Telomerase Activity Correlates with the Stabilities of Genome and DNA Ploidy in Renal Cell Carcinoma | [
"Cancer Research"
] | ||
Beyond the Watching: Understanding Viewer Interactions in Crowdsourced Live Video Broadcasting Services | [
"Electrical and Electronic Engineering",
"Media Technology"
] | ||
Structural studies of (.pi.-C5H5)2MX2 complexes and their derivatives. Structure of (1,1'-trimethylene-.pi.-dicyclopentadienyl)hafnium dichloride | [
"Inorganic Chemistry",
"Physical and Theoretical Chemistry"
] | ||
Production of antibodies to ganglioside GM1 in lymphocyte cultures from patients with diseases of the motor neuron | Journal of Neuroimmunology | [
"Neurology (clinical)",
"Neurology",
"Immunology",
"Immunology and Allergy"
] | |
SPECIFIC RECEPTOR-MEDIATED STIMULATION OF PROGESTERONE SECRETION AND cGMP ACCUMULATION BY RAT ATRIAL NATRIURETIC FACTOR IN CULTURED HUMAN GRANULOSA-LUTEIN (G-L) CELLS | [
"Endocrinology"
] | ||
Assembly technology-No isolated approach | [
"Industrial and Manufacturing Engineering",
"Computer Science Applications",
"Mechanical Engineering",
"Software",
"Control and Systems Engineering"
] | ||
Inhomogeneity of powder packing in compacts and strength of the ceramics obtained | [
"Materials Chemistry",
"Ceramics and Composites"
] | ||
3-D vision technology applied to advanced minimally invasive surgery systems | [
"Surgery"
] | ||
Acute paraspinal compartment syndrome as an unusual cause of severe low back pain | [
"Emergency Medicine"
] | ||
Association of SRAP markers with juvenile wood basic density and growth traits in Cunninghamia lanceolata (Lamb.) Hook | [
"Plant Science",
"Forestry"
] | ||
Effects of an intensive diet and exercise program on lipids in postmenopausal women | Women's Health Issues | [
"Maternity and Midwifery",
"Public Health, Environmental and Occupational Health",
"Obstetrics and Gynecology",
"Health (social science)"
] | |
EU Accession from Within? An Introduction | [
"Law",
"Political Science and International Relations"
] | ||
Superplastic-like forming of non-superplastic AA5083 combined with mechanical pre-forming | [
"Industrial and Manufacturing Engineering",
"Computer Science Applications",
"Mechanical Engineering",
"Software",
"Control and Systems Engineering"
] | ||
ESTUDO DE AVALIAÇÃO TÉCNICA DE MACARRÃO ADITIVADO COM CONCENTRADO PROTÉICO ANIMAL. | Aceitabilidade absoluta e relativa de macarrão aditivado com concentrado protéico animal a nível de 3% e macarrão convencional. Análises físico-químicas e microbiológicas determinaram as características dos produtos. Análise sensorial realizada com diversas formas definiu o perfil dos produtos através equipe treinada de degustadores. Teste de aceitabilidade escolar apresentou bom índice de aceitabilidade. | [
"Animal Science and Zoology"
] | |
Risk of liver, oesophageal and stomach cancers in female textile workers | [
"Public Health, Environmental and Occupational Health"
] | ||
Schlieren-based techniques for investigating instability development and transition in a hypersonic boundary layer | [
"Fluid Flow and Transfer Processes",
"Mechanics of Materials",
"Computational Mechanics"
] | ||
Evaluation of haemodynamic changes of uterine arteries using Doppler ultrasonography during different stages of pregnancy in Bos indicus cows | [
"Endocrinology",
"Animal Science and Zoology",
"Biotechnology"
] | ||
Acrylamidevinyl acetate copolymer as a new UCST copolymer: Phase transition and aggregation behavior; an experimental and theoretical study | [
"Materials Chemistry",
"Polymers and Plastics",
"Biochemistry",
"Environmental Chemistry"
] | ||
Little used surgical techniques of value | [
"Surgery"
] | ||
Uniqueness of the solution to the secular equation for viscoelastic surface waves | [
"Applied Mathematics"
] | ||
Integrated management of the environment for sustainable development | Environmental Science and Pollution Research | [
"Health, Toxicology and Mutagenesis",
"Pollution",
"Environmental Chemistry"
] | |
Image interpolation for progressive transmission by using radial basis function networks | [
"Artificial Intelligence",
"Computer Networks and Communications",
"Computer Science Applications",
"Software"
] | ||
Critical Concerns When Incorporating Telepractice in Outpatient Settings and Private Practice | [
"Pharmacology (medical)",
"Psychiatry and Mental Health",
"Pediatrics, Perinatology and Child Health"
] | ||
On Using a Clustering Approach for Global Climate Classification | Abstract Classifying the land surface into climate types provides means of diagnosing relations between Earth’s physical and biological systems and the climate. Global climate classifications are also used to visualize climate change. Clustering climate datasets provides a natural approach to climate classification, but the rule-based Köppen–Geiger classification (KGC) is the one most widely used. Here, a comprehensive approach to the clustering-based classification of climates is presented. Local climate is defined as a multivariate time series of mean monthly climatic variables and the authors propose to use dynamic time warping (DTW) as a measure of dissimilarity between local climates. Also discussed are the choice of climatic variables, the importance of their proper normalization, and the advantage of using distance-based clustering algorithms. Using the WorldClim global climate dataset and different combinations of clustering parameters, 32 different clustering-based classifications are calculated. These classifications are compared between themselves and to the KGC using the information-theoretic V measure. It is found that the best classifications are obtained using three climate variables (temperature, precipitation, and temperature range), a data normalization that takes into account the skewed distribution of precipitation values, and the partitioning around medoids clustering algorithm. Two such classifications are compared in detail between each other and to the KGC. About half of the climate types found by clustering can be matched to the familiar KGC classes, but the rest differ in their climatic character and spatial distribution. Finally, it is demonstrated that clustering-based classification results in climate types that are internally more homogeneous and externally more distinct than climate types in the KGC. | Journal of Climate | [
"Atmospheric Science"
] |
Les patients porteurs d’une mutation de HRPT2 | Annales d'Endocrinologie | [
"Endocrinology",
"Endocrinology, Diabetes and Metabolism"
] | |
The one-loop renormalization of the MSSM Higgs sector and its application to the neutral scalar Higgs masses | [
"Physics and Astronomy (miscellaneous)",
"Engineering (miscellaneous)"
] | ||
We should not impose narrow restrictions on psychological methods | Hertwig and Ortmann suggest greater standardization of procedures in experimental psychology to help with problems of replicability and consistency of findings. It is argued that, (a) this view is inconsistent with their other interesting proposals, and (b) heterogeneity of method is appropriate in psychology. | [
"Behavioral Neuroscience",
"Physiology",
"Neuropsychology and Physiological Psychology"
] | |
5. Systemic lupus erythematosus: a clinical conundrum in pregnancy | Rheumatology Advances in Practice | [
"Rheumatology"
] | |
The Origin and Development of Vaiṣṇavism | [
"Cultural Studies"
] | ||
Notes and Abstracts | [
"Sociology and Political Science"
] | ||
3GPP SA2 architecture and functions for 5G mobile communication system | ICT Express | [
"Artificial Intelligence",
"Computer Networks and Communications",
"Hardware and Architecture",
"Information Systems",
"Software"
] | |
Magnetic field processed solid-state dye-sensitized solar cells with nickel oxide modified agarose electrolyte | Journal of Power Sources | [
"Electrical and Electronic Engineering",
"Physical and Theoretical Chemistry",
"Energy Engineering and Power Technology",
"Renewable Energy, Sustainability and the Environment"
] | |
Learning TFIDF Enhanced Joint Embedding for Recipe-Image Cross-Modal Retrieval Service | [
"Information Systems and Management",
"Computer Networks and Communications",
"Computer Science Applications",
"Hardware and Architecture"
] | ||
Multilocular Renal Cyst | [
"Cell Biology",
"Pathology and Forensic Medicine"
] | ||
Successful Treatment of Pulmonary Artery Sarcoma by a Two-drug Combination Chemotherapy Consisting of Ifosfamide and Epirubicin | [
"Cancer Research",
"Radiology, Nuclear Medicine and Imaging",
"Oncology"
] | ||
Zinc Efficiency Is Correlated with Enhanced Expression and Activity of Zinc-Requiring Enzymes in Wheat | Abstract Zinc (Zn) is an essential micronutrient for plants. The ability of plants to maintain significant yields under low Zn is termed Zn efficiency (ZE) and its genetic and mechanistic basis is still not well understood. Previously, we showed that root Zn uptake did not play a role in ZE. In the current study, Zn-efficient and -inefficient wheat (Triticum aestivum) genotypes were grown for 13 d in chelate buffer nutrient solutions at low (0.1 pm), sufficient (150 pm), and high (1 μm) Zn2+ activities and analyzed for root-to-shoot translocation of Zn, subcellular leaf Zn distribution, and activity and expression of the Zn-requiring enzymes in leaves. No correlation between ZE and Zn translocation to the shoot was found. Furthermore, total and water-soluble concentrations of leaf Zn were not associated with ZE, and no differences in subcellular Zn compartmentation were found between Zn-efficient and -inefficient genotypes. However, the expression and activity of the Zn-requiring enzymes copper (Cu)/Zn superoxide dismutase (SOD) and carbonic anhydrase did correlate with differences in ZE. Northern analysis suggested that Cu/ZnSOD gene expression was up-regulated in the Zn-efficient genotype, Kirgiz, but not in inefficient BDME. Under Zn deficiency stress, the very Zn-efficient genotype Kirgiz and moderately Zn-efficient Dagdas exhibited an increased activity of Cu/ZnSOD and carbonic anhydrase when compared with Zn-inefficient BDME. These results suggest that Zn-efficient genotypes may be able to maintain the functioning of Zn-requiring enzymes under low Zn conditions; thus, biochemical Zn utilization may be an important component of ZE in wheat. | [
"Plant Science",
"Genetics",
"Physiology"
] | |
PRE-OPERATIVE PAIN EDUCATION: CHILDREN AND PARENTS' PERSPECTIVES | [
"Anesthesiology and Pain Medicine",
"Neurology (clinical)"
] | ||
Investigation on anomalous thermal enhancement and temperature sensing properties of Zn3Mo2O9:Yb3+/RE3+ (RE = Er/Ho) phosphors | In this work, Yb3+/RE3+ (RE = Er/Ho) co-doped Zn3Mo2O9 phosphors were synthesized by high-temperature solid-state reactions. | [
"Inorganic Chemistry"
] | |
Cobalt Nanocluster-Decorated N-Rich Hierarchical Carbon Architectures Efficiently Catalyze Oxygen Reduction and Hydrogen Evolution Reactions | [
"Renewable Energy, Sustainability and the Environment",
"Environmental Chemistry"
] | ||
Membrane stability (thermal) and nature of fatty acids in yeast cells | [
"Cell Biology",
"Molecular Biology",
"Biochemistry",
"Biophysics"
] | ||
PO-1280 Albumin-to-alkaline phosphatase ratio is not a predictor of survival in cervical cancer patients | [
"Radiology, Nuclear Medicine and Imaging",
"Oncology",
"Hematology"
] | ||
Assessment of Wind Speed Estimation From C-Band Sentinel-1 Images Using Empirical and Electromagnetic Models | [
"Electrical and Electronic Engineering"
] | ||
Thickness touchless measurements using eddy current sensors Electric machines and power systems, Vol. 17, No. 2, pp. 125–137 (1989) | [
"Mechanical Engineering",
"Condensed Matter Physics"
] | ||
Introduction | [
"Orthopedics and Sports Medicine",
"Surgery"
] | ||
Using a Key Function Approach to Performance Improvement: A Case Study | [
"Public Health, Environmental and Occupational Health",
"Health Policy"
] | ||
Kinematic considerations for reducing the circulating power effects in gear-type continuously variable transmissions | The present study deals with the kinematic analysis and design considerations of a continuously variable transmission (CVT) utilizing non-circular gear (NCG) sets with phase shift and summing differentials. The kinematic relationships are developed with emphasis on the effect of the different design parameters on reducing the circulating power inherent in this type of system. The study shows that a compromise has to be made between the number of non-circular gear sets to be used and the circulating power generated in the system. For the illustrative example of a 200 hp (149 kW) system it is shown that, for a gear ratio range from 1 to 4 and the considered characteristic curve on the non-circular gears, four sets of summing differentials are estimated to be required and the maximum instantaneous circulating power at the worst condition would be approximately 6 times the output power. The circulating power changes from its minimum of 1.5 to its maximum value with an average circulating power of 2.8 times the output power. | [
"Mechanical Engineering",
"Aerospace Engineering"
] | |
Bibliography—Editors’ selection of current world literature | [
"Cardiology and Cardiovascular Medicine"
] | ||
Column and batch sorption investigations of nickel(II) on extractant-impregnated resin | [
"Health, Toxicology and Mutagenesis",
"Pollution",
"Environmental Chemistry"
] | ||
Implications of structural genomics target selection strategies: Pfam5000, whole genome, and random approaches | Proteins: Structure, Function, and Bioinformatics | [
"Molecular Biology",
"Biochemistry",
"Structural Biology"
] | |
A reaction network for the hydrothermal liquefaction of Nannochloropsis sp. | Algal Research | [
"Agronomy and Crop Science"
] | |
Differences in the metabolism of epicainide in rats and man | [
"Health, Toxicology and Mutagenesis",
"Pharmacology",
"Toxicology",
"Biochemistry"
] | ||
Cell Cycle in the Fucus Zygote Parallels a Somatic Cell Cycle but Displays a Unique Translational Regulation of Cyclin-Dependent Kinases | [
"Cell Biology",
"Plant Science"
] | ||
Crosstalk reduction for VLSI | [
"Electrical and Electronic Engineering",
"Computer Graphics and Computer-Aided Design",
"Software"
] | ||
REVIEWS | The Review of English Studies | [
"Literature and Literary Theory",
"Linguistics and Language",
"Language and Linguistics"
] | |
Efficient removal of As(III) from aqueous solution by S-doped copper-lanthanum bimetallic oxides: Simultaneous oxidation and adsorption | [
"Industrial and Manufacturing Engineering",
"Environmental Chemistry"
] | ||
Drug–drug interaction between itraconazole capsule and efavirenz in adults with HIV for talaromycosis treatment | AbstractObjectivesTo assess the pharmacokinetic of itraconazole capsule formulation and its active metabolite, hydroxyitraconazole, in adults with HIV diagnosed with talaromycosis in an endemic area, and to evaluate the drug–drug interaction between itraconazole/hydroxyitraconazole (ITC/OH-ITC) and efavirenz.MethodsOpen-label, single arm, sequential pharmacokinetic study. Eligible subjects were adults with HIV, ≥18 years old, with confirmed talaromycosis, initiating itraconazole capsule as part of standard talaromycosis treatment, in whom efavirenz-based ART was anticipated. Steady-state pharmacokinetic assessments (pre-dose and at 1, 3, 4, 5, 6, 8 and 12 h post dose) were performed for itraconazole/hydroxyitraconazole without and with efavirenz use. Mid-dose efavirenz concentrations were also assessed. Pharmacokinetics parameters were calculated using non-compartmental analysis.ResultsTen subjects (70% male) were enrolled. At entry, median (range) age was 29.5 years (22–64), and CD4 cell count was 18.0 (1–39) cells/mm3. Geometric mean (95% CI) of itraconazole and hydroxyitraconazole AUC0–12 without efavirenz were 9097 (6761–12 239) and 11 705 (8586-15 959) ng·h/mL, respectively, with a median metabolic ratio of OH-ITC : ITC of 1.3 (95% CI 0.9–1.9). Intra-subject comparison revealed that both itraconazole and hydroxyitraconazole exposures were significantly reduced with concomitant efavirenz use, with the mean AUC0–12 of itraconazole and hydroxyitraconazole being 86% (71%–94%) and 84% (64%–97%) lower, respectively. With efavirenz, itraconazole trough concentrations were also below the recommended therapeutic level (0.5 μg/mL). All subjects had mid-dose efavirenz concentrations >1000 ng/mL.ConclusionsConcomitant administration of itraconazole capsule with efavirenz significantly reduced itraconazole and hydroxyitraconazole exposures. The clinical impact of this drug–drug interaction on talaromycosis treatment or prophylaxis in the era of potent ART needs further evaluation. | [
"Infectious Diseases",
"Pharmacology (medical)",
"Pharmacology",
"Microbiology (medical)"
] | |
Structure and function of colicin E3 | [
"Molecular Biology",
"Biochemistry"
] | ||
Determination of iron(II) and total iron in environmental water samples by flow injection analysis with column preconcentration of chelating resin functionalized with N-hydroxyethylethylenediamine ligands and chemiluminescence detection | [
"Analytical Chemistry"
] | ||
Gulf Stream Ring Trajectories | [
"Oceanography"
] | ||
Cluster-Based Joint Resource Allocation with Successive Interference Cancellation for Ultra-Dense Networks | [
"Computer Networks and Communications",
"Hardware and Architecture",
"Information Systems",
"Software"
] |
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