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10,011,203 | Hypertension develops in about 10% to 50% of patients with nephrosis or cirrhosis and peripheral edema, but the hemodynamic mechanism of the hypertension and its reversal by diuretic therapy has not been elucidated. In eight patients with marked edema and mild hypertension, diuretics (furosemide and spironolactone) dec... | [
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10,011,204 | Influence of double genetic polymorphism on response to sulfamethazine. | [
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10,011,205 | Combined effects of a double genetic polymorphism on sulfamethazine-induced changes in erythrocyte-reduced glutathione (GSH) concentration were investigated in 16 healthy Ghanaian men. The subjects were divided into four subgroups on the basis of their glucose-6-phosphate dehydrogenase (G-6-PD) activity levels and acet... | [
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10,011,206 | Active metabolites of imipramine and desipramine in man. | [
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10,011,207 | Active hydroxy metabolites of imipramine (IMI) and desipramine (DMI) have been quantified in plasma and cerebrospinal fluid (CSF) from patients at steady-state. In plasma of prepubescent boys and adults the concentration of unconjugated 2-hydroxyimipramine is only 15% to 25% that of IMI; 2-hydroxydesipramine (OH-DMI) c... | [
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10,011,208 | Nondichotomous patterns of medication usage: the yes-no fallacy. | [
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10,011,209 | The pharmacology of verapamil. IV. Kinetic and dynamic effects after single intravenous and oral doses. | [
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10,011,210 | Kinetics and plasma level-effect correlates for verapamil were studied in 20 normal young men (mean age, 25.2 +/- 3.6 yr). In a randomized four-way crossover design, each subject received 10 mg verapamil intravenously and 80, 120, and 160 mg in single oral doses. Changes in heart rate, blood pressure, and PR interval w... | [
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10,011,211 | Influence of long-term infusions on lidocaine kinetics. | [
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10,011,212 | Lidocaine kinetics were examined during continuous infusions in five healthy subjects using stable isotope lidocaine labeled with two deuterium atoms. During phase 1, lidocaine and stable isotope lidocaine (50 mg IV each) were given as a bolus to confirm that the two species were kinetically identical. Phase 2 consiste... | [
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10,011,213 | Amiodarone kinetics after oral doses. | [
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10,011,214 | Amiodarone serum kinetics after single oral doses and after long-term therapy were investigated in patients with ventricular tachyarrhythmias. When amiodarone was given as a single oral dose (1400 to 1800 mg, n = 6), serum levels of amiodarone and its metabolite, measured by high-performance liquid chromatography, corr... | [
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10,011,215 | Effect of glycerol and hyperosmolality on intracranial pressure. | [
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10,011,216 | Glycerol has been used in cerebral edema for hyperosmolar dehydration of brain tissue, but only empirical relationships govern this use. Since the efficacy of treatment with glycerol would likely increase with data on the relationship between drug blood levels and intracranial pressure (ICP), we examined the clinical p... | [
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10,011,217 | Relative potency of amiloride and spironolactone in healthy man. | [
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10,011,218 | The renal antimineralocorticoid activity of single oral doses of amiloride, a physiologic aldosterone antagonist, was compared to that of spironolactone, a competitive aldosterone antagonist, in 12 healthy men pretreated with fludrocortisone. For up to 20 hr amiloride induced linear log dose-urinary electrolyte respons... | [
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10,011,219 | Aspirin blocks nicotinic acid-induced flushing. | [
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10,011,220 | Nicotinic acid flushing after placebo and 975-mg oral doses of aspirin was assessed in 29 normal subjects over a range of nicotinic acid doses. Intensity of flushing was assessed by the change in malar thermal circulation index (delta MTCI). Aspirin pretreatment resulted in smaller delta MTCIs at the higher doses of ni... | [
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10,011,221 | Effects of total plasma concentration and age on tolbutamide plasma protein binding. | [
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10,011,222 | Tolbutamide plasma protein binding at different total tolbutamide concentrations was determined in 44 healthy, nonsmoking, drug-free men from 23 to 87 yr old. The data showed that unbound drug increased with total tolbutamide plasma concentration and with age, but that neither the binding equilibrium constant nor the n... | [
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10,011,223 | Free and bound choline blood levels after phosphatidylcholine. | [
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10,011,224 | In six normal subjects we investigated the effects of oral phosphatidylcholine (lecithin) on the concentrations of plasma choline, erythrocyte choline, and choline-containing lipids. Plasma choline levels rose 1 hr after treatment and remained elevated for 8 hr, with peaks at 3 and 4 hr after phosphatidylcholine. Eryth... | [
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10,011,225 | Kinetics of subcutaneous NPH insulin in diabetics. | [
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10,011,226 | Kinetics of subcutaneous NPH insulin were studied in newly diagnosed insulin-dependent diabetics. Using a biotelemetric technique with small Geiger-Müller detectors applied to the skin surface, the disappearance of 125I-NPH insulin fron subcutis was monoexponential with a mean half-life of 6.6 +/- 3.3 (SD) hr. A model ... | [
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10,011,227 | Oxaprozin disposition in renal disease. | [
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10,011,228 | Effects of renal disease on the disposition kinetics of oxaprozin, a nonsteroidal antiinflammatory analgesic, were assessed in 15 subjects who were normal, renally impaired, or who had been undergoing hemodialysis. Oral dose clearance (Cloral), volume of distribution at steady-state (V88d), and elimination half-life (t... | [
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10,011,229 | Cigarette smoking and chlorpromazine disposition and actions. | [
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10,011,230 | Chlorpromazine, 75 mg, was taken by eight cigarette smokers and nine nonsmokers. Mean maximum percent decrease in mean blood pressure with change in position from lying to standing during the first 10 hr after chlorpromazine was 46% greater in nonsmokers than in smokers. Of the eight smokers, six did not become sleepy ... | [
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10,011,231 | Total hepatectomy and hepatic vascular exclusion in the rat: a comparison, with special reference to the influence of body temperature. | [
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10,011,232 | 1. The effects of two procedures for dehepatization, total hepatectomy and complete hepatic vascular exclusion were compared in the rat, and the influence of decreasing the body temperature from 37.5 degrees to 35.5 degrees C on the course of dehepatization was evaluated. 2. The duration of survival after total hepatec... | [
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10,011,233 | Intravenous infusion of alpha-oxoisocaproate: influence on amino acid and nitrogen metabolism in patients with liver cirrhosis. | [
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10,011,234 | 1. The metabolic effect of alpha-oxoisocaproate (4-methyl-2-oxovalerate) infusion was examined in six patients with cirrhosis and in nine healthy control subjects. The arterial concentrations of amino acids, urea, ammonia, insulin and catecholamines were determined in the basal state and during intravenous infusion of ... | [
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10,011,235 | Effects of (+)-octanoylcarnitine on deoxyribonucleic acid synthesis in regenerating rabbit liver. | [
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10,011,236 | 1 (+)-Octanoylcarnitine, a potent inhibitor of fatty acid oxidation, was infused intraportally into rabbits after 70% hepatectomy, and its effects on the rate of deoxyribonucleic acid (DNA) synthesis were examined. 2. The rate of DNA synthesis was markedly enhanced 48 h after hepatectomy. At this time, synthesis was de... | [
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10,011,237 | Glutamine production rate and its contribution to urinary ammonia in normal man. | [
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10,011,238 | 1. Glutamine [15N]amide was infused at a steady rate of 33.34 mumol/h into seven male adult volunteers who were in the fed state and normal acid-base status. 2. Plasma glutamine amide N enrichment and urinary ammonia N enrichment rose to a constant rate within 3 h. 3. The glutamine production rate was 51.8 +/- 7.9 mmol... | [
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-0.01803279109299183,
-0.009000756777822971,
0.04... |
10,011,239 | Baroreceptor stimulation and isometric exercise in normotensive and borderline hypertensive subjects. | [
0.0021857270039618015,
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0.0524... |
10,011,240 | 1. The effects of carotid baroreceptor stimulation (neck chamber) on systemic haemodynamics were determined for normotensive and borderline hypertensive subjects during periods of resting and isometric exercise. 2. Both groups reacted to baroreceptor stimulation with a similar decrease in mean arterial pressure and car... | [
-0.0024429343175143003,
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0.016227997839450836,
... |
10,011,241 | Multiple molecular forms of human heart cytoplasmic aspartate aminotransferase. | [
-0.06034034118056297,
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-0.0850815698504448,
0.027790242806077003,
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0.02... |
10,011,242 | 1. Cytoplasmic aspartate aminotransferase was isolated and purified from human heart with a final specific activity of 236 units/mg of protein. 2. Three distinct peaks of aspartate aminotransferase activity were detected by isoelectric focusing with isoelectric points of 5.46, 5.60 and 5.71. Two minor subforms were als... | [
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0.026592859998345375,
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0.03159... |
10,011,243 | [Therapy of migraine]. | [
-0.017242446541786194,
-0.03258371353149414,
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0.07905036211013794,
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0.01459475513547659,
0.017120148986577988,
0.012875168584287167,
0.008... |
10,011,244 | [Effectiveness of aminophylline therapy of chronic bronchial asthma in children]. | [
0.04187607020139694,
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0.07007087022066116,
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0.005406202748417854,
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0.11746501922607422,
0.034687865525484085,
0.11963111... |
10,011,245 | [High-titer adrenal cortex extracts as collateral therapy in pulmonary tuberculosis]. | [
0.0019702580757439137,
0.03341077268123627,
-0.0486597940325737,
0.019863516092300415,
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0.02114482782781124,
0.058946121484041214,
0.05... |
10,011,246 | [Indications for the use of phosphocreatine in cardiology]. | [
0.04883331432938576,
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0.029172174632549286,
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0.030679404735565186,
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0.08... |
10,011,247 | [Antiblastic monochemotherapy in a case of inoperable ovarian tumor]. | [
0.02356143668293953,
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0.012696962803602219,
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0.05846911668777466,
0.015319391153752804,
-0.057... |
10,011,248 | Subcellular distribution of aspartate aminotransferase isoenzymes in chicken heart: quantitative study. | [
0.011302102357149124,
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-0.08736743777990341,
0.05288483947515488,
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0.029591886326670647,
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-0.04199257120490074,
0.06... |
10,011,249 | 1. The content of the two aspartate aminotransferase isoenzymes in isolated mitochondria and in the cytosolic fraction from chicken heart was determined by radioimmunoassays. 2. The cationic isoenzyme was found to be associated with the mitochondrial fraction; its content measured in the cytosolic fraction was within t... | [
0.00009674971079220995,
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0.018453383818268776,
0.... |
10,011,250 | The kinetics of ligand binding for diverse mammalian myoglobins and the effects of substitutions outside the heme cavity. | [
0.03477594628930092,
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0.0029173442162573338,
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0.07... |
10,011,251 | 1. We report rate constants for oxygen dissociation and for oxygen, carbon monoxide, azide, and cyanide binding to whale, horse, dog, beef and human myoglobins. 2. For azide binding, rate constants can vary by at least a factor of two for substitutions outside the heme cavity. Azide binding may be affected by a substit... | [
-0.02505960874259472,
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0.006388512905687094,
0.012633230537176132,
-0.029288683086633682,
0.084648... |
10,011,252 | Electrophoretic analysis of the plasma and urinary proteins and the ceruloplasmin oxidase activity of heterozygous tortoiseshell (Moto/+) female mice (Mus musculus). | [
0.008939743041992188,
0.004171025939285755,
0.018863175064325333,
0.0373118594288826,
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0.02523091807961464,
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-0.025744449347257614,
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0.09046... |
10,011,253 | Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species. | [
-0.03526514396071434,
-0.09992088377475739,
0.035333629697561264,
-0.005201849155128002,
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-0.0007247604662552476,
0.026606131345033646,
-0.06270498037338257,
-0.06815212965011597,
... |
10,011,254 | 1. Large variations have been observed in the cholesteryl ester transfer activity of lipoprotein-free plasma isolated from 16 vertebrate species. 2. The different species have been arbitrarily divided into low, intermediate and high transfer activity groups, with man in the intermediate group. 3. Cholesteryl ester tran... | [
-0.017883213236927986,
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0.0012562691699713469,
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-0.021244604140520096,
0.04338705912232399,
-0.019085802137851715,
-0.04121871665120125,
... |
10,011,255 | An electrophoretic analysis of plasma proteins of selected birds and snakes. | [
0.016874803230166435,
0.012402266263961792,
0.0297373216599226,
0.02134404517710209,
0.036240387707948685,
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0.011564075946807861,
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-0.12397477775812149,
-0.02381342090666294,
0.15977... |
10,011,256 | Erythrocyte enzymes in Ovis aries. Effect of cell age. | [
0.00028943849611096084,
0.006978364661335945,
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0.022155050188302994,
0.06188170984387398,
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0.02632381021976471,
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-0.022668983787298203,
-0.024804161861538887,
0.04290667921304703,
-0.08618196099996567,
0.014... |
10,011,257 | 1. Activities of 20 red cell enzymes were compared in 8 normal female Ovis Aries, in a serially bled ewe followed by 243 days, and in young and old red cell populations separated by density gradient centrifugation. 2. These comparisons indicate that the erythrocyte enzymes which show significant changes with cell age a... | [
0.003757660510018468,
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0.02795928344130516,
-0.09494633972644806,
-0.0... |
10,011,258 | Studies on the endogenous phosphatides of mammalian pancreas and their hydrolysis by endogenous phospholipases - I. The lipids of dog pancreas and their in vitro hydrolysis, primed by trypsin, by phospholipase A2. | [
-0.021916162222623825,
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-0.03083423338830471,
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-0.06074608862400055,
0.1227... |
10,011,259 | 1. The phosphoglyceride and sphingolipid content of dog pancreas has been determined and their in vitro response to the endogenous lipolytic enzymes, initiated by trypsin, at pH 7.4 was examined by TLC technology. 2. The glyceryl ether phosphatides were found to consist primarily of PE and PC, each with alkyl and alk-1... | [
-0.03436194732785225,
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-0.045601602643728256,
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-0.01570877432823181,
0.033176254481077194,
-0.043924033641815186,
-0.04630475118756294,
0.... |
10,011,260 | Lipid composition of selected tissues of the hardshell clam, Mercenaria mercenaria. | [
0.029802288860082626,
0.0216505229473114,
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-0.06837891787290573,
-0... |
10,011,261 | 1. The total lipids and lipid classes from six tissues of Mercenaria mercenaria were determined. 2. Polar lipids accounted for the largest fraction of lipids. The highest concentration of polar lipids was found in the gill. 3. Free sterols were found only in trace amounts in the gill but were found in much higher quant... | [
0.03857915475964546,
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0.05170762166380882,
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-0.08563823997974396,
-0.04... |
10,011,262 | A technique for assaying the activities of alpha-GPD, LDH, and MDH in the teleost, the goldfish, Carassius auratus. | [
-0.006566115655004978,
-0.028265617787837982,
-0.018197715282440186,
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0... |
10,011,263 | 1. A spectrophotometric assay using rho-iodo-nitro-triphenyl tetrazolium chloride as the indicator was developed for splenic tissue in the goldfish Carassius auratus. 2. This technique permits a rapid test for the activities of the enzymes lactic dehydrogenase, malic dehydrogenase, and alpha-glycerophosphate dehydrogen... | [
0.015440954826772213,
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0.05515323579311371,
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-0.0536821149289608,
0.0... |
10,011,264 | Incorporation and turnover of essential fatty acids in phospholipids and neutral lipids of rainbow trout. | [
-0.01461363397538662,
-0.008994697593152523,
-0.05607915669679642,
0.0019295235397294164,
0.03154393285512924,
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0.04517555609345436,
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-0.07804245501756668,
-0.... |
10,011,265 | 1. The turnover of rainbow trout (Salmo gairdneri) lipid was monitored in fish receiving essential fatty acids (EFA) replete and EFA deficient diets using [1-14C]-linolenic acid (C18:3 omega 3). 2. Forty percent of administered radioactivity was recovered in total lipid after 7 days. 3. Eighty-five percent of incorpora... | [
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-0.04647001624107361,
-0.00... |
10,011,266 | Isoelectric focusing of the alanine aminotransferase isoenzymes from the brain, liver and kidney. | [
0.0012708185240626335,
-0.0992477685213089,
-0.05015493184328079,
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0.042752705514431,
0.043287910521030426,
-0.028626317158341408,
-0.04413536190986633,
0.037253... |
10,011,267 | 1. The isoelectric points of mitochondrial and cytosolic alanine aminotransferases (EC 2.6.1.2) of bovine brain cortex, of rat, guinea-pig and human livers and of rat and pig kidney cortices were estimated. 2. The pI of the cytosolic enzymes were found at about 5.2 and those of mitochondrial ones at 7.2. 3. It is sugge... | [
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0.005504691042006016,
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0.03941318020224571,
0.09218969941139221,
-0.019312327727675438,
0.012682801112532616,
0.026... |
10,011,268 | Volatile sulfur compounds responsible for an offensive odor of the flat-head, Calliurichthys doryssus. | [
-0.016256384551525116,
0.046754829585552216,
0.04194929823279381,
-0.006266187410801649,
0.014090047217905521,
0.004921897314488888,
0.012261731550097466,
0.028778057545423508,
0.0951656922698021,
-0.030026622116565704,
0.013675018213689327,
-0.05966692790389061,
-0.01681172288954258,
0.00... |
10,011,269 | 1. The volatiles of a flat-head, Calliurichthys doryssus, which gives out a characteristic offensive odor in living time, were analyzed by gas chromatography. 2. A large quantity of volatile sulfur compounds was detected in the flat-head; of which methyl mercaptan and/or dimethyl disulfide were judged to be responsible... | [
0.022657474502921104,
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0.06276559829711914,
0.012129340320825577,
0.05868564918637276,
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0.038451749831438065,
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0.06676706671714783,
-0.0291108638048172,
0.01856628991663456,
-0.07861918210983276,
-0.013354992493987083,
0.03689523... |
10,011,270 | Localization, characterization and partial purification of TMAO-ase. | [
-0.060876961797475815,
0.02431473135948181,
-0.034722451120615005,
-0.036310549825429916,
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0.04175041988492012,
0.06491368263959885,
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0.01486979890614748,
0.030649613589048386,
-0.030310658738017082,
-0.0702090784907341,
0.04... |
10,011,271 | 1. Formaldehyde (FA) and dimethylamine (DMA) are generated in several species of fish of commercial importance. 2. The present study describes the localization, partial purification and characterization of an enzyme recovered from cod kidney tissue which is responsible for the reduction of trimethylamine oxide (TMAO) t... | [
-0.033651791512966156,
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0.03706768527626991,
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-0.04290325194597244,
-0.080377958714962,
0.022... |
10,011,272 | Evolution of gluconeogenic enzyme activities during starvation in liver and kidney of the rainbow trout (Salmo gairdneri). | [
-0.020361965522170067,
-0.04139174148440361,
-0.04598930478096008,
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-0.07594095170497894,
0.0... |
10,011,273 | 1. There was a general increase in the activities of enzymes involved in gluconeogenesis in liver and kidney of rainbow trout, Salmo gairdneri, during the second month of starvation. 2. The need of gluconeogenesis during the first month of the starvation period was probably minimal because of the utilization of liver g... | [
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0.02784007601439953,
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-0.06231732666492462,
-0.02... |
10,011,274 | Comparison of carotenoids in the ovaries of marine fish and shellfish. | [
-0.017879383638501167,
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0.008630197495222092,
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0.05899808183312416,
-0.09476790577173233,
-0.06786160171031952,
... |
10,011,275 | 1. The following carotenoids were isolated and identified: astaxanthin diester, tunaxanthin monoester, astaxanthin monoester, tunaxanthin, astaxanthin, doradexanthin, lutein, zeaxanthin, idoxanthin, triol and tetrol from nine species of fish; astaxanthin diester, astaxanthin monester, astaxanthin, doradexanthin, zeaxan... | [
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0.014143762178719044,
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10,011,276 | Further characterization of two mitochondrial populations in tuna heart ventricle. | [
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0.05678243935108185,
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10,011,277 | 1. Mitochondria were isolated from the spongy and compact ventricular myocardium of adult Thunnus thynnus thynnus L. 2. Measurement of the succinoxidase activity of phosphorylating mitochondria revealed that those from the spongy had an apparent Km being half of that of the mitochondria from the compact layer. These la... | [
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0.06970760971307755,
-0.02... |
10,011,278 | Patterns of purine nucleotides in some North Sea fish erythrocytes. | [
-0.017201364040374756,
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0.022517405450344086,
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10,011,279 | 1. The purine nucleotides were determined in the whole blood of 13 species of seawater teleosts and 3 species of selachians. 2. The ATP/ADP ratio ranged from 4 to 50 in the erythrocytes of the fish examined. 3. GTP is widely distributed in fish erythrocytes but its level ranged from 2 to 27 nmol/mg Hb, the highest valu... | [
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0.020... |
10,011,280 | A program for multiple hypothesis tests. | [
-0.008570740930736065,
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0.003914962522685528,
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... |
10,011,281 | Computer-assisted oral and intravenous theophylline therapy. | [
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0.023059312254190445,
0.06107553094625473,
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0.10435138642787933,
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0.10115... |
10,011,282 | A low-overhead laboratory data management system for the PDP11. | [
-0.058966606855392456,
0.06624855101108551,
-0.01676418073475361,
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0.02914544939994812,
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-0.045... |
10,011,283 | ROSFIT: an enzyme kinetics nonlinear regression curve fitting package for a microcomputer. | [
-0.05195605382323265,
-0.10887297242879868,
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0.017372332513332367,
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0.... |
10,011,284 | An improved deconvolution technique for the calculation of renal retention functions. | [
-0.022972969338297844,
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0.07941389828920364,
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0.054194897413253784,
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... |
10,011,285 | Computer processing of echo-mechanocardiograms: methods and results. | [
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0.028145480901002884,
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0.0012569522950798273,
0.03291087597608566,... |
10,011,286 | A new system for long-term recording and processing of heart rate and physical activity in outpatients. | [
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0.031704217195510864,
0.02552502043545246,
-0.001839617965742945... |
10,011,287 | Measurement of three-dimensional positions and motions of large numbers of spherical radiopaque markers from biplane cineradiograms. | [
0.04014555364847183,
0.0011275410652160645,
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0.029939545318484306,
0.0... |
10,011,288 | Inhibition of implantation by the intrauterine administration of phospholipases in the rat. | [
0.0034517026506364346,
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0.094... |
10,011,289 | Phospholipases A2 and C (93 and 500 mU) were administered to uterine horns of Long-Evans adult rats during the first five days of pregnancy. As control material, saline (0.15 M) was administered to contralateral uterine horns. The animals were sacrificed on the ninth day of pregnancy, the uterine horns were removed and... | [
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0.05159857124090195,
0.0028711743652820587,
0.03933875262737274,
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0.054162... |
10,011,290 | Endometrial morphology and peripheral steroid levels in women with and without intermenstrual bleeding during contraception with the 300 microgram norethisterone (NET) minipill. | [
0.03539165481925011,
0.01564222015440464,
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0.024932613596320152,
0.047894418239593506,
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0.01... |
10,011,291 | Demonstration of an early abortifacient effect of norethisterone (NET) in the primate (baboon). | [
0.0028225546702742577,
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0.03099864348769188,
0.0373... |
10,011,292 | A long-acting injectable contraceptive which provides continuous controlled release of norethisterone (NET) for three months following a single intramuscular injection was tested for antifertility effects in baboons using a low dose of microcapsules (total NET dose 2.5 mg; daily dose approximately 0.03 mg/day) which ha... | [
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0.07235576957464218,
0.06512169539928436,
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0.0226720... |
10,011,293 | Cerebral and hemodynamic variables during cough-induced CPR in dogs. | [
-0.006053407210856676,
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0.... |
10,011,294 | To assess the potential of self administered, cough-induced cardiopulmonary resuscitation (CICPR) to sustain cerebral function during sudden onset ventricular fibrillation (VF), the authors studied four groups of six dogs each. Cough was simulated by: spontaneous gasping (group 1); cough elicited by bilateral electrica... | [
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0.068... |
10,011,295 | Postcraniotomy diabetes insipidus. Who's at risk? | [
-0.011247674003243446,
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0.01661... |
10,011,296 | Diabetes insipidus (DI) is thought to be a relatively common complication after craniotomy procedures. To identify subsets of patients at risk for this problem, the postoperative courses of 135 consecutive patients undergoing craniotomy were scrutinized retrospectively. All patients received similar anesthetic manageme... | [
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0.0053... |
10,011,297 | A new double-lumen central venous catheter. | [
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0.02079089917242527,
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... |
10,011,298 | Modification of the infant Laerdal resuscitation bag to monitor airway pressure. | [
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0.0270... |
10,011,299 | Blood clot resulting in ball-valve obstruction in the airway. | [
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10,011,300 | Rocky Mountain Spotted fever from St. Louis county. Implications for early diagnosis and treatment. | [
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0.03... |
10,011,301 | Reanimatology today. Some scientific and philosophic considerations. | [
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0.0655256... |
10,011,302 | Reanimatology--the science of resuscitation. | [
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0.016539715230464935,
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0.0... |
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